estrogen receptor modulator - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	estrogen receptor modulator	go back to main search page
Accession:	CHEBI:50739	browse the term
Definition:	A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure.

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Rat (3312 ) Mouse (3380 ) Human (3325 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (11 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (3312)

chlorotrianisene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase pi 1

multiple interactions

ISO

Chlorotrianisene inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

serpin family C member 1

decreases expression

ISO

Chlorotrianisene results in decreased expression of SERPINC1

NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 2, acylglycerol lipase

decreases expression

ISO

Clomiphene results in decreased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

androgen receptor

affects binding
multiple interactions

EXP
ISO

Clomiphene binds to AR protein
Clomiphene binds to and results in decreased activity of AR protein; Clomiphene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

PMID:14565775 PMID:25752796 PMID:33049310

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

carbonic anhydrase 12

decreases expression

ISO

Clomiphene results in decreased expression of CA12 mRNA

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:76,169,815...76,225,465

G

cyclin D1

decreases expression

ISO

Clomiphene results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin G2

increases expression

ISO

Clomiphene results in increased expression of CCNG2 mRNA

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206

G

C-X-C motif chemokine ligand 12

decreases expression

ISO

Clomiphene results in decreased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

Clomiphene results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

Clomiphene results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

ISO

Clomiphene results in decreased expression of DKK1 protein

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

ephrin A1

increases expression

ISO

Clomiphene results in increased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

early growth response 3

decreases expression

ISO

Clomiphene results in decreased expression of EGR3 mRNA

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

estrogen receptor 1

multiple interactions
affects binding

ISO

Clomiphene binds to and results in decreased activity of ESR1 protein; Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Clomiphene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]
Clomiphene binds to ESR1 protein

PMID:9048584 PMID:15521089 PMID:19233257 PMID:25012808 PMID:25752796 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

increases activity
affects binding
multiple interactions

EXP
ISO

Clomiphene results in increased activity of ESR2 protein
Clomiphene binds to Esr2 protein
Clomiphene binds to and results in decreased activity of ESR2 protein
Clomiphene binds to ESR2 protein
Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]

CTD
RGD

PMID:9048584 PMID:12224631 PMID:19211805 PMID:25752796 PMID:9048584

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

coagulation factor III, tissue factor

increases expression

ISO

Clomiphene results in increased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

coagulation factor V

affects response to substance

ISO

F5 gene polymorphism affects the susceptibility to Clomiphene

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247

G

forkhead box C1

decreases expression

ISO

Clomiphene results in decreased expression of FOXC1 mRNA

NCBI chr17:32,840,119...32,844,100
Ensembl chr17:32,805,858...32,844,347

G

follicle stimulating hormone subunit beta

multiple interactions
increases expression

ISO

Clomiphene promotes the reaction [Alcohols results in increased expression of FSHB protein]
Clomiphene results in increased expression of FSHB protein

PMID:1915937 PMID:8590623

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

gonadotropin releasing hormone 1

multiple interactions

ISO

Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

homeobox A10

decreases expression

ISO

Clomiphene results in decreased expression of HOXA10 mRNA; Clomiphene results in decreased expression of HOXA10 protein

NCBI chr 4:82,662,204...82,671,490
Ensembl chr 4:82,662,204...82,665,922

G

inhibitor of DNA binding 3

increases expression

ISO

Clomiphene results in increased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

integrin subunit beta 3

decreases expression

ISO

Clomiphene results in decreased expression of ITGB3 protein
Clomiphene results in decreased expression of ITGB3 mRNA; Clomiphene results in decreased expression of ITGB3 protein

PMID:15749485 PMID:26603317

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

iodotyrosine deiodinase

multiple interactions

ISO

Clomiphene inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:42,410,130...42,426,386

G

Janus kinase 2

decreases expression

ISO

Clomiphene results in decreased expression of JAK2 mRNA

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

kynureninase

increases expression

ISO

Clomiphene results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

luteinizing hormone subunit beta

increases secretion
multiple interactions

ISO

Clomiphene results in increased secretion of LHB protein
Clomiphene promotes the reaction [Alcohols results in increased expression of LHB protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein]

PMID:3891423 PMID:8590623

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIF, interleukin 6 family cytokine

increases expression
decreases expression

ISO

Clomiphene results in increased expression of LIF mRNA
Clomiphene results in decreased expression of LIF mRNA; Clomiphene results in decreased expression of LIF protein

PMID:21851939 PMID:26603317

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

MYB proto-oncogene, transcription factor

decreases expression

ISO

Clomiphene results in decreased expression of MYB mRNA

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYB proto-oncogene like 1

decreases expression

ISO

Clomiphene results in decreased expression of MYBL1 mRNA

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

nicotinamide riboside kinase 1

decreases expression

ISO

Clomiphene results in decreased expression of NMRK1 mRNA

NCBI chr 1:225,475,975...225,503,414
Ensembl chr 1:225,475,830...225,503,602

G

nuclear receptor subfamily 1, group I, member 2

increases activity
multiple interactions

ISO

Clomiphene results in increased activity of NR1I2 protein
Clomiphene binds to and results in increased activity of NR1I2 protein
[Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Clomiphene binds to and results in increased activity of NR1I2 protein

PMID:25455453 PMID:33049310

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

olfactomedin 1

decreases expression

ISO

Clomiphene results in decreased expression of OLFM1 mRNA

NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:31,918,573...31,956,260

G

PDZ domain containing 1

decreases expression

ISO

Clomiphene results in decreased expression of PDZK1 mRNA

NCBI chr 2:187,064,995...187,096,348
Ensembl chr 2:187,065,013...187,096,806

G

progesterone receptor

increases expression
multiple interactions

ISO

Clomiphene results in increased expression of PGR protein
Clomiphene binds to and results in decreased activity of PGR protein

PMID:15749485 PMID:25752796

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphoinositide-3-kinase regulatory subunit 3

increases expression

ISO

Clomiphene results in increased expression of PIK3R3 mRNA

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762

G

protein kinase C, epsilon

affects localization

ISO

Clomiphene affects the localization of PRKCE protein

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

prolactin

multiple interactions

ISO

Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]; Clomiphene inhibits the reaction [Estradiol results in increased secretion of PRL protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein]

PMID:3891423 PMID:17054466

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

serine protease 23

decreases expression

ISO

Clomiphene results in decreased expression of PRSS23 mRNA

NCBI chr 1:152,815,301...152,835,005
Ensembl chr 1:152,813,670...152,947,871

G

prostaglandin E synthase

decreases expression

ISO

Clomiphene results in decreased expression of PTGES mRNA

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

RB binding protein 8, endonuclease

decreases expression

ISO

Clomiphene results in decreased expression of RBBP8 mRNA

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:3,197,310...3,263,985

G

RNA terminal phosphate cyclase-like 1

decreases expression

ISO

Clomiphene results in decreased expression of RCL1 mRNA

NCBI chr 1:236,238,078...236,282,597
Ensembl chr 1:236,238,031...236,315,894

G

ret proto-oncogene

decreases expression

ISO

Clomiphene results in decreased expression of RET mRNA

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556

G

serum/glucocorticoid regulated kinase 1

decreases expression

ISO

Clomiphene results in decreased expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

serum/glucocorticoid regulated kinase family, member 3

decreases expression

ISO

Clomiphene results in decreased expression of SGK3 mRNA

NCBI chr 5:14,128,628...14,255,099
Ensembl chr 5:14,126,257...14,198,331

G

sex hormone binding globulin

affects binding

ISO

Clomiphene binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

siah E3 ubiquitin protein ligase 2

decreases expression

ISO

Clomiphene results in decreased expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873

G

spermine oxidase

decreases expression

ISO

Clomiphene results in decreased expression of SMOX mRNA

NCBI chr 3:139,184,793...139,220,174
Ensembl chr 3:139,184,798...139,220,170
Ensembl chr X:139,184,798...139,220,170

G

single-stranded DNA binding protein 2

increases expression

ISO

Clomiphene results in increased expression of SSBP2 mRNA

NCBI chr 2:24,385,494...24,673,768
Ensembl chr 2:24,385,687...24,673,768

G

supervillin

decreases expression

ISO

Clomiphene results in decreased expression of SVIL mRNA

NCBI chr17:57,343,910...57,539,508
Ensembl chr17:57,343,910...57,462,660

G

transcription factor AP-2 alpha

increases expression

ISO

Clomiphene results in increased expression of TFAP2A mRNA

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219

G

transcription factor AP-2 gamma

decreases expression

ISO

Clomiphene results in decreased expression of TFAP2C mRNA

NCBI chr 3:181,733,524...181,742,412
Ensembl chr 3:181,733,419...181,741,404

G

tissue factor pathway inhibitor

increases expression

ISO

Clomiphene results in increased expression of TFPI mRNA

NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742

G

thyroid hormone receptor alpha

multiple interactions

ISO

Clomiphene binds to and results in increased activity of THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor beta

multiple interactions

ISO

Clomiphene binds to and results in increased activity of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

ethynodiol diacetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

affects localization
multiple interactions

ISO

Ethynodiol Diacetate affects the localization of AR protein
Ethynodiol Diacetate binds to and results in increased activity of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

LY 117018 results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

estrogen receptor 1

affects binding

ISO

LY 117018 binds to ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

LY 117018 results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [LY 117018 results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

ISO

LY 117018 results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [LY 117018 results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

protein tyrosine phosphatase, non-receptor type 13

increases expression

ISO

LY 117018 results in increased expression of PTPN13 mRNA

NCBI chr14:6,412,841...6,587,238
Ensembl chr14:6,412,841...6,587,171

G

RNA binding motif protein 17

multiple interactions

ISO

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:71,846,941...71,863,834
Ensembl chr17:71,846,916...71,864,431

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein D

multiple interactions

ISO

Ospemifene inhibits the reaction [Estradiol results in decreased expression of APOD protein]

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

androgen receptor

multiple interactions
decreases expression
affects expression

ISO

[Ospemifene co-treated with Estradiol] results in decreased expression of AR protein
Ospemifene results in decreased expression of AR protein
Ospemifene affects the expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

estrogen receptor 1

decreases expression
multiple interactions

ISO

Ospemifene results in decreased expression of ESR1 mRNA; Ospemifene results in decreased expression of ESR1 protein
Ospemifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

interleukin 6

multiple interactions

ISO

Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

trefoil factor 1

decreases expression
multiple interactions

ISO

Ospemifene results in decreased expression of TFF1 mRNA; Ospemifene results in decreased expression of TFF1 protein
Ospemifene inhibits the reaction [Estradiol results in increased expression of TFF1 protein]

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

TNF receptor superfamily member 11B

multiple interactions

ISO

Ospemifene results in increased expression of and results in increased secretion of TNFRSF11B protein

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-associated tyrosine kinase

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of AATK mRNA

NCBI chr10:105,789,171...105,825,634
Ensembl chr10:105,785,469...105,825,618

G

ATP binding cassette subfamily B member 1A

decreases expression
affects activity
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of ABCB1 mRNA; Raloxifene Hydrochloride results in decreased expression of ABCB1 protein
ABCB1 protein affects the activity of Raloxifene Hydrochloride
[Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 mRNA; [Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 protein

PMID:16959878 PMID:17096884

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 9

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ABCB9 mRNA

NCBI chr12:38,146,659...38,192,862
Ensembl chr12:38,159,904...38,192,860

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily G member 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

abhydrolase domain containing 2, acylglycerol lipase

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ABHD5 mRNA

NCBI chr 8:130,877,834...130,903,947
Ensembl chr 8:130,877,703...130,903,947

G

abhydrolase domain containing 8

affects response to substance

ISO

ABHD8 affects the susceptibility to Raloxifene Hydrochloride

NCBI chr16:18,178,441...18,185,178
Ensembl chr16:18,178,441...18,191,638

G

actin binding LIM protein family, member 3

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ABLIM3 mRNA

NCBI chr18:57,527,917...57,646,936
Ensembl chr18:57,527,917...57,646,710

G

aggrecan

multiple interactions

EXP

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in decreased expression of ACAN mRNA]

NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779

G

angiotensin I converting enzyme

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ACE mRNA

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

acetylcholinesterase

decreases activity

ISO

Raloxifene Hydrochloride results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

atypical chemokine receptor 3

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of ACKR3 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214

G

acyl-CoA synthetase long-chain family member 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

actin alpha 2, smooth muscle

multiple interactions

ISO

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

activin A receptor like type 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ACVRL1 mRNA; Raloxifene Hydrochloride results in increased expression of ACVRL1 protein

NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305

G

ADAM metallopeptidase domain 19

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA

NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455

G

ADAM metallopeptidase domain 22

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ADAM22 mRNA

NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:26,671,112...26,925,843

G

ADAMTS-like 3

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ADAMTSL3 mRNA

NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:145,698,004...146,006,195

G

adenylate cyclase 2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ADCY2 mRNA

NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645

G

adenylate cyclase activating polypeptide 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ADCYAP1 mRNA

NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:120,550,328...120,556,383

G

adhesion G protein-coupled receptor A3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ADGRA3 mRNA

NCBI chr14:65,085,418...65,188,949
Ensembl chr14:65,087,380...65,188,959

G

adhesion G protein-coupled receptor B2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ADGRB2 mRNA

NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:147,611,580...147,646,726

G

adhesion G protein-coupled receptor G1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ADGRG1 mRNA

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of ADH1 mRNA

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

adiponectin, C1Q and collagen domain containing

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adenosine A2a receptor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adenosine A2B receptor

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA

NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091

G

adrenoceptor alpha 1A

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of ADRA1A mRNA

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

AE binding protein 1

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of AEBP1 mRNA

NCBI chr14:84,951,577...84,962,840
Ensembl chr14:84,952,822...84,962,843

G

argonaute RISC catalytic component 2

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of AGO2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

angiotensinogen

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

adenosylhomocysteinase-like 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of AHCYL1 mRNA

NCBI chr 2:197,982,335...198,016,770
Ensembl chr 2:197,982,344...198,033,930

G

AHNAK nucleoprotein

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of AHNAK mRNA

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

aryl hydrocarbon receptor

multiple interactions
affects binding
affects localization

ISO

[Raloxifene Hydrochloride results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA
Raloxifene Hydrochloride binds to AHR protein
Raloxifene Hydrochloride inhibits the reaction [Methylcholanthrene binds to AHR protein]
Raloxifene Hydrochloride affects the localization of AHR protein

PMID:19901195 PMID:24481452

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of AIMP1 mRNA

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994

G

adenylate kinase 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

A-kinase anchoring protein 1

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA
Raloxifene Hydrochloride affects the expression of AKAP1 mRNA

PMID:14699072 PMID:19059307

NCBI chr10:74,118,232...74,151,366
Ensembl chr10:74,119,124...74,138,190

G

aldo-keto reductase family 7, member A2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions
increases phosphorylation

ISO
EXP

Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein
Raloxifene Hydrochloride inhibits the reaction [TGFA protein results in increased phosphorylation of AKT1 protein]
Raloxifene Hydrochloride results in increased phosphorylation of AKT1 protein

PMID:15590986 PMID:15876410 PMID:16798746 PMID:25537862 PMID:35007301

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aminolevulinate dehydratase

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ALAD mRNA

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

5'-aminolevulinate synthase 2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ALAS2 mRNA

NCBI chr X:22,890,650...22,914,046
Ensembl chr X:22,890,689...22,914,043

G

activated leukocyte cell adhesion molecule

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of ALCAM mRNA]

NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876

G

arachidonate 5-lipoxygenase

multiple interactions

ISO

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ALOX5 mRNA

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

alkaline phosphatase, biomineralization associated

multiple interactions

EXP

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of ALPL mRNA]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

adhesion molecule with Ig like domain 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA

NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218

G

angiomotin like 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of AMOTL2 mRNA

NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:112,181,863...112,198,030

G

angiogenin

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ANG mRNA

NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106

G

angiopoietin-like 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ANGPTL2 mRNA

NCBI chr 3:36,914,876...36,944,715
Ensembl chr 3:36,914,745...36,945,876

G

angiopoietin like 7

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ANGPTL7 mRNA

NCBI chr 5:164,215,223...164,220,408
Ensembl chr 5:164,215,223...164,220,584

G

ankyrin 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ANK3 mRNA

NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,601,826...19,084,879

G

ankyrin repeat domain 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA

NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:243,228,448...243,263,751

G

ankyrin repeat domain 28

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA

NCBI chr16:6,924,868...7,056,593
Ensembl chr16:6,924,882...7,056,593

G

aminopeptidase O

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of AOPEP mRNA

NCBI chr17:1,817,001...2,133,008
Ensembl chr17:1,817,001...2,133,104

G

aldehyde oxidase 1

multiple interactions
decreases activity

ISO

Raloxifene Hydrochloride inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]
Raloxifene Hydrochloride results in decreased activity of AOX1 protein

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

adaptor related protein complex 1 subunit gamma 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of AP1G1 mRNA

NCBI chr19:54,654,101...54,740,586
Ensembl chr19:54,620,807...54,740,586

G

APC regulator of WNT signaling pathway

multiple interactions
affects response to substance

ISO

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ALOX5 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCL6 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCND1 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CTNNB1 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ESR2 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LAMB1 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PCNA protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGES mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 protein

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases expression

EXP

[Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA
Raloxifene Hydrochloride results in increased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

apolipoprotein D

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of APOD mRNA
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of APOD protein]

PMID:16514628 PMID:27163517

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

apolipoprotein E

multiple interactions

ISO

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ACTA2 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CD68 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL6 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to IL6 protein] which affects the phosphorylation of STAT3 protein]

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amyloid beta precursor protein

multiple interactions
affects binding

ISO

Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA]; Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TNF mRNA]
Raloxifene Hydrochloride binds to APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

androgen receptor

decreases expression
multiple interactions
affects expression

ISO
EXP

Raloxifene Hydrochloride results in decreased expression of AR mRNA; Raloxifene Hydrochloride results in decreased expression of AR protein
[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of AR protein
Raloxifene Hydrochloride affects the expression of AR mRNA

PMID:11867264 PMID:15731164 PMID:16837883 PMID:27163517

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

amphiregulin

multiple interactions
increases expression
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AREG mRNA
Raloxifene Hydrochloride results in increased expression of AREG mRNA
Raloxifene Hydrochloride inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
Raloxifene Hydrochloride results in decreased expression of AREG mRNA

PMID:16514628 PMID:19022889 PMID:19059307 PMID:26865669

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

arginase 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375

G

Rho GTPase activating protein 29

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ARHGAP29 mRNA

NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:212,755,803...212,986,729

G

AT-rich interaction domain 5A

multiple interactions

ISO

ARID5A protein inhibits the reaction [Raloxifene Hydrochloride results in increased activity of ESR1 protein]

NCBI chr 9:46,030,513...46,058,729
Ensembl chr 9:46,030,548...46,045,363

G

AT-rich interaction domain 5B

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ARID5B mRNA

NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686

G

ARF like GTPase 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ARL1 mRNA

NCBI chr 7:25,007,401...25,018,572
Ensembl chr 7:25,006,981...25,019,319

G

ARF like GTPase 4C

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA
Raloxifene Hydrochloride affects the expression of ARL4C mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:96,748,075...96,751,510
Ensembl chr 9:96,745,069...96,752,772

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ISO

ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of NQO1 protein]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ARNT2 mRNA

NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:147,599,058...147,801,997

G

ankyrin repeat and SOCS box-containing 13

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA

NCBI chr17:71,474,531...71,493,238
Ensembl chr17:71,474,531...71,505,633

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

activating transcription factor 3

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ATF3 mRNA
Raloxifene Hydrochloride results in increased expression of ATF3 mRNA

PMID:16497877 PMID:19059307

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 7 interacting protein

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ATF7IP mRNA

NCBI chr 4:171,117,122...171,202,871
Ensembl chr 4:171,117,122...171,202,867

G

autophagy related 12

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [ATG12 protein binds to ATG5 protein]

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261

G

autophagy related 5

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [ATG12 protein binds to ATG5 protein]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

ATPase Na+/K+ transporting subunit alpha 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ATP1A1 mRNA

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase phospholipid transporting 9A (putative)

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ATP9A mRNA

NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:177,779,203...178,023,661

G

ataxin 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ATXN3 mRNA

NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:126,839,327...126,872,781

G

aurora kinase A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

arginine vasopressin

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of AVP mRNA
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; U 0126 inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

axin 2

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of AXIN2 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of AXIN2 mRNA

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575

G

BCL2-associated agonist of cell death

increases cleavage

ISO

Raloxifene Hydrochloride results in increased cleavage of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2-antagonist/killer 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of BAK1 mRNA

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BRCA1 associated deubiquitinase 1

multiple interactions

ISO

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of BAP1 mRNA

NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,452,974...6,461,952

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

ISO

Raloxifene Hydrochloride affects the expression of BAX protein
[Raloxifene Hydrochloride co-treated with Resveratrol] results in increased expression of BAX mRNA
Raloxifene Hydrochloride results in increased expression of BAX mRNA

PMID:16009171 PMID:29705353

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

brain enriched myelin associated protein 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of BCAS1 mRNA

NCBI chr 3:179,554,754...179,637,800
Ensembl chr 3:179,551,704...179,637,743

G

BCL2, apoptosis regulator

affects expression
multiple interactions
increases expression
decreases expression

ISO

Raloxifene Hydrochloride affects the expression of BCL2 protein
[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of BCL2 mRNA
Raloxifene Hydrochloride results in increased expression of BCL2 protein
Raloxifene Hydrochloride results in decreased expression of BCL2 mRNA; Raloxifene Hydrochloride results in decreased expression of BCL2 protein

PMID:16009171 PMID:16566921 PMID:16973256 PMID:17220163 PMID:20945400 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

BCL3, transcription coactivator

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA]

NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368

G

BCL6, transcription repressor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

beclin 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

bone gamma-carboxyglutamate protein

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of BGLAP protein

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

biglycan

increases expression

ISO
EXP

Raloxifene Hydrochloride results in increased expression of BGN mRNA

PMID:15576828 PMID:19429434

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799

G

basic helix-loop-helix family, member e40

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

baculoviral IAP repeat-containing 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

basic leucine zipper nuclear factor 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of BLZF1 mRNA

NCBI chr13:79,174,898...79,190,116
Ensembl chr13:79,174,902...79,190,116

G

bone morphogenetic protein 7

affects expression

ISO

Raloxifene Hydrochloride affects the expression of BMP7 mRNA

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137

G

BMP/retinoic acid inducible neural specific 2

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of BRINP2 mRNA]

NCBI chr13:72,964,498...73,065,312
Ensembl chr13:72,964,502...73,065,294

G

BTG anti-proliferation factor 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

complement C1q B chain

affects expression

EXP

Raloxifene Hydrochloride affects the expression of C1QB mRNA

NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840

G

C2 calcium-dependent domain containing 2

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA
Raloxifene Hydrochloride affects the expression of C2CD2 mRNA

PMID:14699072 PMID:19059307

NCBI chr11:50,694,680...50,759,096
Ensembl chr11:50,694,563...50,759,016

G

complement C3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

similar to human chromosome 14 open reading frame 132

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of C14ORF132 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA

PMID:14699072 PMID:19059307

NCBI chr 6:130,130,176...130,163,153
Ensembl chr 6:130,130,794...130,158,762

G

carbonic anhydrase 12

affects expression
decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of CA12 mRNA
Raloxifene Hydrochloride results in decreased expression of CA12 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CA12 mRNA

PMID:14699072 PMID:19059307 PMID:26865669

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:76,169,815...76,225,465

G

carbonic anhydrase 4

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CA4 mRNA

NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916

G

calcineurin binding protein 1

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of CABIN1 mRNA

NCBI chr20:12,892,750...13,014,801
Ensembl chr20:12,892,771...13,014,800

G

calcium voltage-gated channel subunit alpha1 H

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CACNA1H mRNA

NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771

G

calcium voltage-gated channel subunit alpha1 I

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CACNA1I mRNA

NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:113,716,266...113,827,670

G

calbindin 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CALB2 mRNA

NCBI chr19:55,023,849...55,050,858
Ensembl chr19:55,023,838...55,057,952

G

caldesmon 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CALD1 mRNA

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

calmodulin 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

cyclase associated actin cytoskeleton regulatory protein 2

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of CAP2 mRNA

NCBI chr17:18,260,462...18,409,681
Ensembl chr17:18,261,646...18,409,563

G

calpain 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CAPN2 mRNA

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625

G

caspase recruitment domain family, member 10

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CARD10 mRNA

NCBI chr 7:112,210,944...112,252,044
Ensembl chr 7:112,210,776...112,239,806

G

cask-interacting protein 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA

NCBI chr10:101,526,131...101,540,362
Ensembl chr10:101,526,195...101,540,349

G

caspase 3

increases expression
multiple interactions
increases cleavage
decreases expression

ISO
EXP

Raloxifene Hydrochloride results in increased expression of CASP3 mRNA; Raloxifene Hydrochloride results in increased expression of CASP3 protein modified form
[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of CASP3 mRNA; STAT3 protein affects the reaction [Raloxifene Hydrochloride results in increased cleavage of CASP3 protein]
Raloxifene Hydrochloride results in decreased expression of CASP3 mRNA; Raloxifene Hydrochloride results in decreased expression of CASP3 protein
Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased activity of CASP3 protein]

PMID:20945400 PMID:22965848 PMID:23385821 PMID:27999800 PMID:28430601 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CASP4 mRNA

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 7

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA
Raloxifene Hydrochloride affects the expression of CASP7 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions
increases expression
decreases expression

ISO

[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of CASP8 mRNA
Raloxifene Hydrochloride results in increased expression of CASP8 mRNA
Raloxifene Hydrochloride results in decreased expression of CASP8 mRNA; Raloxifene Hydrochloride results in decreased expression of CASP8 protein

PMID:27999800 PMID:29705353

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

catalase

increases activity

ISO

Raloxifene Hydrochloride results in increased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

affects expression
increases expression
multiple interactions

ISO
EXP

Raloxifene Hydrochloride affects the expression of CAV1 mRNA
Raloxifene Hydrochloride results in increased expression of CAV1 mRNA; Raloxifene Hydrochloride results in increased expression of CAV1 protein
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of CAV1 mRNA]; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of CAV1 protein]

PMID:14699072 PMID:17091190

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

chromobox 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CBX1 mRNA

NCBI chr10:82,266,746...82,286,431
Ensembl chr10:82,266,759...82,287,242

G

chromobox 3

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CBX3 mRNA

NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:81,876,649...81,889,911

G

C-C motif chemokine ligand 2

multiple interactions
decreases activity
affects expression

ISO
EXP

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL2 mRNA; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CCL2 protein]
Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]
Raloxifene Hydrochloride affects the expression of CCL2 mRNA

PMID:14699072 PMID:17006379 PMID:19059307 PMID:25305410

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of CCL20 mRNA
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL20 mRNA

PMID:14699072 PMID:19059307 PMID:24722370

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 3

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to CCL3 promoter]; Raloxifene Hydrochloride inhibits the reaction [RELA protein binds to CCL3 promoter]
Raloxifene Hydrochloride results in decreased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

increases expression
decreases expression

ISO

Raloxifene Hydrochloride results in increased expression of CCL5 mRNA
Raloxifene Hydrochloride results in decreased expression of CCL5 protein

PMID:12154049 PMID:16842799

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine ligand 9

multiple interactions

ISO

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCL6 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877

G

cellular communication network factor 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA

NCBI chr 7:87,983,788...87,990,810
Ensembl chr 7:87,982,216...87,994,581

G

cyclin A2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CCNA2 mRNA; Raloxifene Hydrochloride results in increased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CCNB1 mRNA; Raloxifene Hydrochloride results in increased expression of CCNB1 protein

PMID:12154049 PMID:17445807

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression
affects expression

ISO
EXP

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA; [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCND1 mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCND1 mRNA
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CCND1 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CCND1 protein]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of CCND1 mRNA]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of CCND1 protein]
Raloxifene Hydrochloride results in decreased expression of CCND1 mRNA
Raloxifene Hydrochloride affects the expression of CCND1 mRNA

PMID:14699072 PMID:19059307 PMID:22965848 PMID:24080207 PMID:24431404 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E2

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCNE2 mRNA
Raloxifene Hydrochloride results in decreased expression of CCNE2 protein

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin G2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CCNG2 mRNA

PMID:16497877 PMID:26865669

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206

G

Cd200 molecule

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of CD200 mRNA

NCBI chr11:68,916,200...68,943,570
Ensembl chr11:68,916,224...68,943,569

G

CD24 molecule

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of CD24 mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 protein

PMID:16514628 PMID:24431404

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

CD3 gamma subunit of T-cell receptor complex

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CD3G mRNA

NCBI chr 8:54,177,572...54,184,087
Ensembl chr 8:54,177,977...54,183,918

G

CD40 molecule

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

CD44 molecule

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of CD44 mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 protein

PMID:24431404 PMID:26865669

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

CD52 molecule

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CD52 mRNA

NCBI chr 5:151,603,537...151,605,096
Ensembl chr 5:151,603,524...151,605,086

G

Cd68 molecule

multiple interactions

ISO

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CD68 protein]

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

CD74 molecule

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410

G

Cd80 molecule

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

CD86 molecule

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

CD8 subunit alpha

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CD8A mRNA

NCBI chr 4:104,924,116...104,928,353
Ensembl chr 4:104,900,833...104,928,358

G

cell division cycle 6

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241

G

cadherin 2

affects expression
multiple interactions

ISO
EXP

Raloxifene Hydrochloride affects the expression of CDH2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDH2 mRNA

PMID:14699072 PMID:16079270 PMID:19059307

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cadherin 6

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CDH6 mRNA

NCBI chr 2:63,801,630...63,952,309
Ensembl chr 2:63,806,135...63,952,287

G

cyclin-dependent kinase 1

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]; trichostatin A inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]]

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

multiple interactions

EXP

[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CDK2 protein]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

CDK5 regulatory subunit associated protein 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CDK5RAP3 mRNA

NCBI chr10:82,390,845...82,402,814
Ensembl chr10:82,390,845...82,400,001

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO
EXP

Raloxifene Hydrochloride results in increased expression of CDKN1A mRNA; Raloxifene Hydrochloride results in increased expression of CDKN1A protein
[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of CDKN1A mRNA
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CDKN1A protein]

PMID:12154049 PMID:16497877 PMID:24080207 PMID:27017931

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CDKN1B protein

PMID:16536755 PMID:22965848

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cysteine dioxygenase type 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:41,619,070...41,633,891

G

cell adhesion associated, oncogene regulated

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CDON mRNA

NCBI chr 8:42,032,921...42,119,451
Ensembl chr 8:42,033,042...42,119,345

G

CCAAT/enhancer binding protein alpha

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of CEBPA mRNA
IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]

PMID:15849065 PMID:31470850

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

affects expression
increases expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of CEBPB mRNA
Raloxifene Hydrochloride results in increased expression of CEBPB mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA

PMID:14699072 PMID:16497877 PMID:19059307

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

centromere protein A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703

G

ceramide synthase 6

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA

NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544

G

complement factor D

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

chordin

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CHRD mRNA

NCBI chr11:93,676,400...93,685,584
Ensembl chr11:93,676,400...93,685,278

G

cytokine inducible SH2-containing protein

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

creatine kinase B

increases activity
multiple interactions

ISO
EXP

Raloxifene Hydrochloride results in increased activity of CKB protein
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased activity of CKB protein]

PMID:16621514 PMID:17029789

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

chloride voltage-gated channel 4

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA

NCBI chr X:27,290,769...27,356,967
Ensembl chr X:27,290,868...27,356,939

G

chloride voltage-gated channel 6

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CLCN6 mRNA

NCBI chr 5:163,715,593...163,748,301
Ensembl chr 5:163,717,439...163,748,198

G

chloride intracellular channel 4

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

CDC-like kinase 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CLK1 mRNA

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

calmin

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CLMN mRNA

NCBI chr 6:129,470,613...129,572,079
Ensembl chr 6:129,478,149...129,572,027

G

calsyntenin 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CLSTN1 mRNA

NCBI chr 5:165,314,128...165,377,627
Ensembl chr 5:165,314,309...165,377,625

G

clathrin, light chain B

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CLTB mRNA

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915

G

clusterin

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CLU mRNA

PMID:12370124 PMID:16202921

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CNBP mRNA

NCBI chr 4:121,860,102...121,868,976
Ensembl chr 4:121,860,105...121,869,010

G

collagen type X alpha 1 chain

multiple interactions

EXP

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of COL10A1 mRNA]

NCBI chr20:39,737,536...39,744,518
Ensembl chr20:39,716,822...39,751,440

G

collagen type XI alpha 1 chain

affects expression

EXP

Raloxifene Hydrochloride affects the expression of COL11A1 mRNA

NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:204,509,136...204,702,264

G

collagen type I alpha 2 chain

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type XXVI alpha 1 chain

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of COL26A1 mRNA

NCBI chr12:25,429,362...25,575,205
Ensembl chr12:25,429,387...25,575,206

G

collagen type II alpha 1 chain

multiple interactions

EXP

Raloxifene Hydrochloride promotes the reaction [Decitabine results in decreased expression of COL2A1 mRNA]

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

collagen type V alpha 1 chain

affects expression

EXP

Raloxifene Hydrochloride affects the expression of COL5A1 mRNA

NCBI chr 3:31,606,475...31,755,097
Ensembl chr 3:31,606,486...31,753,020

G

collagen type V alpha 2 chain

affects expression

EXP

Raloxifene Hydrochloride affects the expression of COL5A2 mRNA

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

COPI coat complex subunit beta 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of COPB2 mRNA

NCBI chr 8:108,040,687...108,062,810
Ensembl chr 8:108,040,693...108,064,550

G

cytochrome c oxidase, subunit VIIIb

affects expression

EXP

Raloxifene Hydrochloride affects the expression of COX8H mRNA

NCBI chr 1:205,406,813...205,408,273
Ensembl chr 1:205,406,813...205,408,311

G

carboxypeptidase B2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CPB2 protein

NCBI chr15:56,967,128...57,015,964
Ensembl chr15:56,966,839...57,015,962

G

carboxypeptidase E

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CPE mRNA

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524

G

carboxypeptidase M

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CPM mRNA

NCBI chr 7:55,111,599...55,172,114
Ensembl chr 7:55,111,599...55,172,114

G

cAMP responsive element binding protein 1

increases phosphorylation

EXP

Raloxifene Hydrochloride results in increased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to PTGS2 promoter]

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

cysteine-rich secretory protein LCCL domain containing 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA

NCBI chr19:64,961,764...65,020,099
Ensembl chr19:64,961,771...65,020,349

G

crystallin, beta B2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CRYBB2 mRNA

NCBI chr12:49,230,192...49,240,116
Ensembl chr12:49,230,192...49,240,116

G

cold shock domain containing C2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA

NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:115,332,128...115,346,596

G

colony stimulating factor 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CSF1 mRNA

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

colony stimulating factor 1 receptor

multiple interactions

EXP

[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of CSF1R protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride] affects the expression of CSF1R protein

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806

G

colony stimulating factor 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CSF3 mRNA

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

catenin beta 1

multiple interactions
increases expression

ISO
EXP

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CTNNB1 mRNA; IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CTNNB1 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CTNNB1 protein]
Raloxifene Hydrochloride results in increased expression of CTNNB1 protein

PMID:24080207 PMID:24431404 PMID:25571714 PMID:31470850

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin B

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CTSB mRNA

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin H

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CTSH mRNA

NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181

G

cathepsin K

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

CUE domain containing 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA

NCBI chr10:73,389,798...73,484,914
Ensembl chr10:73,389,841...73,483,749

G

CXADR, Ig-like cell adhesion molecule

affects expression

ISO

Raloxifene Hydrochloride affects the expression of CXADR mRNA

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:30,469,526...30,516,988

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 12

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]
Raloxifene Hydrochloride results in decreased expression of CXCL12 mRNA

PMID:19059307 PMID:20549624 PMID:21185374 PMID:26865669

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 2

multiple interactions

EXP

Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cylicin 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CYLC2 mRNA

NCBI chr 5:70,349,791...70,384,673
Ensembl chr 5:70,349,791...70,364,840

G

CYLD lysine 63 deubiquitinase

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of CYLD mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA
Raloxifene Hydrochloride results in decreased expression of CYP19A1 mRNA

PMID:10704911 PMID:19059307

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO
EXP

[Raloxifene Hydrochloride results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; Raloxifene Hydrochloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of CYP1A1 protein]
Raloxifene Hydrochloride results in increased expression of CYP1A1 mRNA; Raloxifene Hydrochloride results in increased expression of CYP1A1 protein

PMID:18493746 PMID:19901195 PMID:24481452

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 26, subfamily a, polypeptide 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of CYP26A1 mRNA

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

cytochrome P450, family 26, subfamily b, polypeptide 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 27, subfamily a, polypeptide 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of CYP27B1 mRNA

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of CYP2A1 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

ISO

Raloxifene Hydrochloride results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein
Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

PMID:15860655 PMID:19299527 PMID:23721565

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

dishevelled-binding antagonist of beta-catenin 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DACT1 mRNA

NCBI chr 6:95,526,645...95,538,625
Ensembl chr 6:95,526,690...95,551,053

G

dystroglycan 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DAG1 mRNA

NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:117,769,517...117,782,199

G

death-domain associated protein

affects expression

ISO

Raloxifene Hydrochloride affects the expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

D-box binding PAR bZIP transcription factor

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of DBP mRNA

NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205

G

discoidin, CUB and LCCL domain containing 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA

NCBI chr11:55,594,691...55,649,113
Ensembl chr11:55,594,691...55,649,085

G

DNA-damage-inducible transcript 4

affects expression

ISO

Raloxifene Hydrochloride affects the expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DExD-box helicase 21

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DDX21 mRNA

NCBI chr20:31,077,044...31,097,238
Ensembl chr20:31,077,045...31,097,238

G

DEAD box helicase 3, Y-linked

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DDX3Y mRNA

NCBI chr Y:1,190,042...1,210,699
Ensembl chr Y:1,191,242...1,210,650

G

DExD-box helicase 50

affects expression

EXP

Raloxifene Hydrochloride affects the expression of DDX50 mRNA

NCBI chr20:31,104,354...31,133,652
Ensembl chr20:31,104,354...31,133,652

G

defensin beta 1

multiple interactions

ISO

[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of DEFB1 mRNA

NCBI chr16:77,001,326...77,016,068
Ensembl chr16:77,001,326...77,016,068

G

DEPP autophagy regulator 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DEPP1 mRNA

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233

G

desumoylating isopeptidase 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DESI2 mRNA

NCBI chr13:92,493,765...92,543,307
Ensembl chr13:92,493,989...92,564,981

G

24-dehydrocholesterol reductase

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

dehydrogenase/reductase 2

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of DHRS2 mRNA]

NCBI chr15:32,658,855...32,673,591
Ensembl chr15:32,659,223...32,673,588

G

DExH-box helicase 9

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DHX9 mRNA

NCBI chr13:68,152,813...68,189,580
Ensembl chr13:68,152,813...68,189,546

G

dicer 1 ribonuclease III

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DICER1 mRNA

NCBI chr 6:129,392,298...129,457,252
Ensembl chr 6:129,396,014...129,457,252

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DKK1 protein

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

dickkopf WNT signaling pathway inhibitor 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DKK2 mRNA

NCBI chr 2:223,242,375...223,334,249
Ensembl chr 2:223,242,377...223,334,724

G

deleted in malignant brain tumors 1

increases expression

EXP
ISO

Raloxifene Hydrochloride results in increased expression of DMBT1 mRNA; Raloxifene Hydrochloride results in increased expression of DMBT1 protein

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:195,047,713...195,126,704

G

DnaJ heat shock protein family (Hsp40) member A1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DNAJA1 mRNA

NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

dynamin binding protein

affects expression

ISO

Raloxifene Hydrochloride affects the expression of DNMBP mRNA

NCBI chr 1:252,685,406...252,778,642
Ensembl chr 1:252,685,406...252,778,688

G

dedicator of cytokinesis 9

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA

NCBI chr15:105,018,341...105,289,799
Ensembl chr15:105,024,912...105,289,799

G

DNA-damage regulated autophagy modulator 1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of DRAM1 mRNA]

NCBI chr 7:24,630,233...24,665,270
Ensembl chr 7:24,630,238...24,664,354

G

dopamine receptor D5

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DRD5 mRNA

NCBI chr14:76,700,244...76,703,344
Ensembl chr14:76,700,241...76,703,466

G

dual specificity phosphatase 2

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of DUSP2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA

PMID:16497877 PMID:19059307

NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:135,009,590...135,011,809

G

dual specificity phosphatase 4

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of DUSP4 mRNA

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:64,079,893...64,093,700

G

dual specificity phosphatase 5

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 6

affects expression

EXP

Raloxifene Hydrochloride affects the expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

dynein, cytoplasmic 1 light intermediate chain 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of DYNC1LI2 mRNA

NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107

G

dynein light chain LC8-type 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

dual specificity tyrosine phosphorylation regulated kinase 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of DYRK2 mRNA

NCBI chr 7:56,235,276...56,265,741
Ensembl chr 7:56,235,276...56,265,942

G

E2F transcription factor 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of E2F2 mRNA

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087

G

enoyl-CoA delta isomerase 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

endothelin 3

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of EDN3 mRNA
ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EDN3 mRNA]

NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:183,980,668...184,005,329

G

endothelin receptor type A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

EGF containing fibulin extracellular matrix protein 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of EFEMP1 mRNA
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of EFEMP1 mRNA]

PMID:14699072 PMID:21185374

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808

G

ephrin A1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation
increases phosphorylation

ISO
EXP

[Raloxifene Hydrochloride co-treated with epigallocatechin gallate] results in decreased phosphorylation of EGFR protein; Raloxifene Hydrochloride results in decreased expression of and affects the localization of EGFR protein
Raloxifene Hydrochloride results in decreased phosphorylation of EGFR protein
Raloxifene Hydrochloride results in increased phosphorylation of EGFR protein

PMID:18371987 PMID:23842642 PMID:24782323

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

egl-9 family hypoxia-inducible factor 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of EGLN3 mRNA

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015

G

early growth response 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 3

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]
Raloxifene Hydrochloride results in decreased expression of EGR3 mRNA

PMID:21185374 PMID:26865669

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

eukaryotic translation initiation factor 1

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EIF1 mRNA
Raloxifene Hydrochloride results in increased expression of EIF1 mRNA

PMID:16497877 PMID:19059307

NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654

G

eukaryotic translation initiation factor 2 subunit alpha

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of EIF5 mRNA

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

eukaryotic translation initiation factor 5A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of EIF5A mRNA

NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330

G

E74 like ETS transcription factor 3

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA
Raloxifene Hydrochloride results in increased expression of ELF3 mRNA

PMID:16202921 PMID:19059307

NCBI chr13:49,242,265...49,247,102
Ensembl chr13:49,242,267...49,247,380

G

elongation factor for RNA polymerase II

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ELL mRNA

NCBI chr16:18,877,751...18,925,449
Ensembl chr16:18,877,751...18,925,076

G

elongin B

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ELOB mRNA

NCBI chr10:13,353,413...13,358,484
Ensembl chr10:13,353,417...13,358,563

G

ELOVL fatty acid elongase 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ELOVL5 mRNA

NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:87,671,159...87,737,616

G

epithelial membrane protein 1

multiple interactions

ISO

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EMP1 mRNA]

NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365

G

ectodermal-neural cortex 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of ENC1 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ENC1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

endonuclease domain containing 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA

NCBI chr 8:19,490,615...19,520,007
Ensembl chr 8:19,490,615...19,520,007

G

endoglin

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ENG mRNA; Raloxifene Hydrochloride results in increased expression of ENG protein

PMID:20135064 PMID:32947957

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933

G

enolase 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA
Raloxifene Hydrochloride affects the expression of ENPP2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleoside triphosphate diphosphohydrolase 2

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of ENTPD2 mRNA

NCBI chr 3:28,611,722...28,617,237
Ensembl chr 3:28,611,772...28,618,184

G

epithelial cell adhesion molecule

multiple interactions

ISO

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM protein

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

Eph receptor A1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

Eph receptor A4

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of EPHA4 mRNA

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

erythropoietin receptor

affects expression

ISO

Raloxifene Hydrochloride affects the expression of EPOR mRNA

NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:28,765,746...28,770,322

G

erb-b2 receptor tyrosine kinase 2

decreases response to substance

ISO

ERBB2 protein results in decreased susceptibility to Raloxifene Hydrochloride

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

erb-b2 receptor tyrosine kinase 3

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ERBB3 mRNA

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of ERBB4 mRNA]

NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772

G

estrogen receptor 1

affects response to substance
decreases expression
increases expression
multiple interactions
affects expression
affects binding
decreases activity
affects folding
increases response to substance

ISO
EXP

ESR1 gene polymorphism affects the susceptibility to Raloxifene Hydrochloride
Raloxifene Hydrochloride results in decreased expression of ESR1 protein
Raloxifene Hydrochloride results in increased expression of ESR1 mRNA; Raloxifene Hydrochloride results in increased expression of ESR1 protein
[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of ESR1 protein; [Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased expression of ESR1 protein; Raloxifene Hydrochloride affects the reaction [Oxygen deficiency affects the expression of ESR1 protein alternative form]; Raloxifene Hydrochloride binds to and affects the folding of ESR1 protein mutant form; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]
Raloxifene Hydrochloride affects the expression of ESR1 mRNA
Raloxifene Hydrochloride metabolite binds to ESR1 protein
ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]
Raloxifene Hydrochloride results in decreased expression of ESR1 mRNA; Raloxifene Hydrochloride results in decreased expression of ESR1 protein
Raloxifene Hydrochloride results in decreased activity of ESR1 protein
Raloxifene Hydrochloride binds to ESR1 protein
[Raloxifene Hydrochloride binds to ESR1 protein] which binds to SERPINB9 protein; [Raloxifene Hydrochloride binds to ESR1 protein] which binds to TFF1 protein; Raloxifene Hydrochloride binds to ESR1 protein
Raloxifene Hydrochloride affects the folding of ESR1 protein
[ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein]; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of LINC00312 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of PLAU mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of SLN mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EIF1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of G0S2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of GRK5 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of IDH2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ISG20 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of LPL mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of MSMB mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PTPRE mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RET mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SGK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SYBU mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TIPARP mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA; ARID5A protein inhibits the reaction [Raloxifene Hydrochloride results in increased activity of ESR1 protein]; ESR1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EMP1 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of HSPA1B mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MFAP5 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased secretion of IL6 protein]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of IDH2 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC2 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC3 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of PLPP3 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TGFB3 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of ZFP36 mRNA]; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride affects the folding of and affects the activity of ESR1 protein; Raloxifene Hydrochloride binds to and affects the activity of ESR1 protein; Raloxifene Hydrochloride binds to and results in decreased activity of ESR1 protein; Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to CCL3 promoter]; Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to RELA protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol binds to ESR1 protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Raloxifene Hydrochloride inhibits the reaction [trichostatin A results in decreased expression of ESR1 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride results in increased activity of and affects the localization of ESR1 protein
ESR1 exon polymorphism results in increased susceptibility to Raloxifene Hydrochloride

PMID:9751507 PMID:11535548 PMID:11867264 PMID:14617632 PMID:14699072 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
increases expression
affects expression
increases activity
decreases activity
increases response to substance

ISO
EXP

[ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein]; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CA12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FADD mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FLNB mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FST mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of IVL mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KAZN mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LBH mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAFF mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAGEA8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MN1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PCTP mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGES mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RET mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RHOF mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SALL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SCNN1A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SEMA3F mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SERPINB6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SSH1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of STK24 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYBU mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNPO mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TGFA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TOB1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of WNT5A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZCCHC24 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZNF395 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AREG mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ATF3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL20 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDH2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DACT1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of EGR1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ENC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of FUT9 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GAD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GRB10 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GYG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of HBEGF mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ID4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of INHBA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of JAG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT17 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT34 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NAB1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of OCLN mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PDP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTX3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RFK mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RGS4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RRAD mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SLCO4C1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SOD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TCIM mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFBI mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TMEM158 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNC mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF11B mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNIK mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRAF5 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA; [trichostatin A co-treated with Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 protein; [trichostatin A co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 mRNA; [trichostatin A co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 protein; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EDN3 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of FLNB mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of IER3 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of KLRC2 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MSMB mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of NCF2 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of GABRR1 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TMT1A mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride binds to and results in increased activity of ESR2 protein; Raloxifene Hydrochloride inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA]; Raloxifene Hydrochloride promotes the reaction [[trichostatin A co-treated with Estradiol] results in increased expression of ESR2 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to ESR2 protein]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to PTGS2 promoter]
Raloxifene Hydrochloride results in increased expression of ESR2 protein
Raloxifene Hydrochloride affects the expression of ESR2 mRNA
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of ESR2 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of ESR2 protein]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of ESR2 mRNA]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of ESR2 protein]
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ESR2 protein; ESR2 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]]; Raloxifene Hydrochloride binds to and affects the activity of ESR2 protein alternative form; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of ESR2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of ESR2 protein]
Raloxifene Hydrochloride results in increased activity of ESR2 protein
Raloxifene Hydrochloride results in decreased activity of ESR2 protein
ESR2 protein results in increased susceptibility to Raloxifene Hydrochloride

PMID:14699072 PMID:15924412 PMID:16798746 PMID:17638070 PMID:17654759 More...

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

ecotropic viral integration site 2A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA

NCBI chr10:64,983,727...64,987,627
Ensembl chr10:64,983,705...64,999,516

G

coagulation factor XI

increases activity

ISO

Raloxifene Hydrochloride results in increased activity of F11 protein

NCBI chr16:53,720,502...53,741,547
Ensembl chr16:53,718,621...53,740,941

G

coagulation factor XII

increases activity

ISO

Raloxifene Hydrochloride results in increased activity of F12 protein

NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664

G

coagulation factor XIII A1 chain

affects expression

ISO

Raloxifene Hydrochloride affects the expression of F13A1 mRNA

NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948

G

coagulation factor II (thrombin) receptor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of F2R mRNA

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579

G

coagulation factor VIII

increases activity
increases expression

ISO

Raloxifene Hydrochloride results in increased activity of F8 protein
Raloxifene Hydrochloride results in increased expression of F8 protein

PMID:15850603 PMID:16359964

NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683

G

fatty acid binding protein 4

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of FABP4 mRNA
Raloxifene Hydrochloride affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein]

PMID:16643890 PMID:31470850

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

Fas associated via death domain

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

family with sequence similarity 171, member B

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of FAM171B mRNA

NCBI chr 3:89,337,566...89,392,973
Ensembl chr 3:89,337,661...89,392,971

G

fibroblast activation protein, alpha

affects expression

ISO

Raloxifene Hydrochloride affects the expression of FAP mRNA

NCBI chr 3:67,547,398...67,616,271
Ensembl chr 3:67,546,921...67,617,601

G

FYVE, RhoGEF and PH domain containing 6

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA

NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:30,484,600...30,595,806

G

fibroblast growth factor 8

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of FGF8 mRNA

NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:254,533,504...254,539,605

G

fibroblast growth factor 9

affects expression

EXP

Raloxifene Hydrochloride affects the expression of FGF9 mRNA

NCBI chr15:36,325,552...36,369,995
Ensembl chr15:36,325,599...36,367,926

G

fibroblast growth factor receptor 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA

NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914

G

four and a half LIM domains 1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of FHL1 mRNA]

NCBI chr X:139,592,794...139,652,290
Ensembl chr X:139,592,604...139,652,282

G

four and a half LIM domains 2

multiple interactions
decreases expression
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA
Raloxifene Hydrochloride results in decreased expression of FHL2 mRNA
Raloxifene Hydrochloride affects the expression of FHL2 mRNA

PMID:14699072 PMID:19059307 PMID:26865669

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

fission, mitochondrial 1

affects expression
increases expression

EXP

Raloxifene Hydrochloride affects the expression of FIS1 mRNA
Raloxifene Hydrochloride results in increased expression of FIS1 mRNA

PMID:15576828 PMID:16079270

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

FKBP prolyl isomerase 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of FKBP3 mRNA

NCBI chr 6:88,850,137...88,862,542
Ensembl chr 6:88,843,879...88,863,447

G

FKBP prolyl isomerase 5

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

filamin B

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of FLNB mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FLNB mRNA; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of FLNB mRNA]

PMID:14699072 PMID:19059307

NCBI chr15:19,392,212...19,525,278
Ensembl chr15:19,392,216...19,525,209

G

filamin C

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of FLNC mRNA

NCBI chr 4:58,999,445...59,027,240
Ensembl chr 4:58,999,547...59,027,240

G

fibronectin leucine rich transmembrane protein 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of FLRT1 mRNA

NCBI chr 1:213,704,983...213,782,958
Ensembl chr 1:213,704,038...213,782,981

G

formin-like 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of FMNL1 mRNA

NCBI chr10:88,615,290...88,643,411
Ensembl chr10:88,615,869...88,643,411

G

fibronectin 1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box A2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of FOXA2 mRNA

NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:155,923,307...155,928,757

G

forkhead box C1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of FOXC1 mRNA

NCBI chr17:32,840,119...32,844,100
Ensembl chr17:32,805,858...32,844,347

G

forkhead box E1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of FOXE1 mRNA

NCBI chr 5:65,425,630...65,428,438
Ensembl chr 5:65,425,630...65,428,438

G

forkhead box O1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of FOXO1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O3

affects localization
multiple interactions

ISO

Raloxifene Hydrochloride affects the localization of FOXO3 protein
ESR1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

follistatin

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of FST mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FST mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491

G

fucosyltransferase 9

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of FUT9 mRNA

NCBI chr 5:44,148,371...44,361,209
Ensembl chr 5:44,146,152...44,362,823

G

forty-two-three domain containing 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of FYTTD1 mRNA

NCBI chr11:81,383,040...81,412,604
Ensembl chr11:81,383,040...81,412,599

G

frizzled class receptor 6

affects expression

ISO

Raloxifene Hydrochloride affects the expression of FZD6 mRNA

NCBI chr 7:71,939,916...71,971,685
Ensembl chr 7:71,939,973...71,971,680

G

G0/G1switch 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

GABA type A receptor-associated protein

affects expression

EXP

Raloxifene Hydrochloride affects the expression of GABARAP mRNA

NCBI chr10:55,213,465...55,216,787
Ensembl chr10:55,212,075...55,216,154

G

gamma-aminobutyric acid type B receptor subunit 2

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of GABBR2 mRNA]

NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:65,743,073...66,083,695

G

GA binding protein transcription factor subunit alpha

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of GABPA mRNA

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059

G

gamma-aminobutyric acid type A receptor subunit gamma 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of GABRG1 mRNA

NCBI chr14:37,750,292...37,821,651
Ensembl chr14:37,750,292...37,989,945

G

gamma-aminobutyric acid type A receptor subunit rho 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of GABRR1 mRNA
ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of GABRR1 mRNA]

NCBI chr 5:52,320,475...52,357,549
Ensembl chr 5:52,320,475...52,357,549

G

glutamate decarboxylase 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GAD1 mRNA

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

galanin and GMAP prepropeptide

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of GAL mRNA

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

growth arrest specific 6

increases expression
affects expression
multiple interactions

ISO
EXP

Raloxifene Hydrochloride results in increased expression of GAS6 mRNA
Raloxifene Hydrochloride affects the expression of GAS6 mRNA
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of GAS6 mRNA]

PMID:16079270 PMID:19429434

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

GATA binding protein 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of GATA2 mRNA

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

glucosaminyl (N-acetyl) transferase 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of GCNT1 mRNA

NCBI chr 1:224,145,104...224,182,496
Ensembl chr 1:224,141,108...224,185,741

G

growth differentiation factor 9

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of GDF9 mRNA

NCBI chr10:38,090,021...38,100,801
Ensembl chr10:38,089,878...38,100,797

G

GDNF family receptor alpha 2

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of GFRA2 mRNA

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782

G

growth hormone 1

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]

NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859

G

growth hormone receptor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of GHR mRNA

NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331

G

growth hormone releasing hormone

affects expression

EXP

Raloxifene Hydrochloride affects the expression of GHRH mRNA

NCBI chr 3:166,412,763...166,432,519
Ensembl chr 3:166,412,764...166,431,880

G

growth hormone releasing hormone receptor

affects expression
affects response to substance

EXP
ISO

Raloxifene Hydrochloride affects the expression of GHRHR mRNA
GHRHR affects the susceptibility to Raloxifene Hydrochloride

PMID:16079270 PMID:32934756

NCBI chr 4:85,830,345...85,863,127
Ensembl chr 4:85,830,486...85,863,127

G

gap junction protein, beta 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of GJB2 mRNA

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877

G

glycine receptor, beta

affects expression

ISO

Raloxifene Hydrochloride affects the expression of GLRB mRNA

NCBI chr 2:168,432,736...168,505,614
Ensembl chr 2:168,432,736...168,505,614

G

glutaredoxin

affects expression

ISO

Raloxifene Hydrochloride affects the expression of GLRX mRNA

NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:7,073,759...7,083,543

G

glutamate-ammonia ligase

affects expression

EXP

Raloxifene Hydrochloride affects the expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

glycine-N-acyltransferase

affects expression

ISO

Raloxifene Hydrochloride affects the expression of GLYAT mRNA

NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:219,128,811...219,150,774

G

G protein subunit beta 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of GNB1 mRNA

NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488

G

G protein subunit beta 4

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of GNB4 mRNA

NCBI chr 2:117,289,112...117,329,050
Ensembl chr 2:117,293,284...117,328,945

G

gonadotropin releasing hormone 1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

golgin A5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of GOLGA5 mRNA

NCBI chr 6:127,377,244...127,405,404
Ensembl chr 6:127,377,236...127,405,403

G

glypican 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of GPC1 mRNA

NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:100,843,645...100,879,933

G

glypican 3

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of GPC3 mRNA

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

G protein-coupled estrogen receptor 1

multiple interactions
increases activity

EXP
ISO

[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein
Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of GPER1 mRNA]
GPER1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of MYC mRNA]

PMID:22453024 PMID:24782323 PMID:24846829 PMID:26200092 PMID:26470790

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

glycoprotein nmb

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of GPNMB mRNA]

NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240

G

G protein-coupled receptor, class C, group 5, member C

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA

NCBI chr10:100,385,682...100,407,953
Ensembl chr10:100,383,631...100,426,962

G

growth factor receptor bound protein 10

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of GRB10 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GRB10 mRNA

PMID:14699072 PMID:19059307

NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387

G

growth regulating estrogen receptor binding 1

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]
Raloxifene Hydrochloride results in decreased expression of GREB1 mRNA

PMID:21185374 PMID:26879975

NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126

G

grainyhead-like transcription factor 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of GRHL1 mRNA

NCBI chr 6:46,935,947...46,986,126
Ensembl chr 6:46,935,967...46,980,264

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

G protein-coupled receptor kinase 5

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of GRK5 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of GRK5 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928

G

glycogenin 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GYG1 mRNA

NCBI chr 2:104,540,927...104,583,038
Ensembl chr 2:104,540,533...104,582,818

G

H19 imprinted maternally expressed transcript

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of H19 mRNA]

NCBI chr 1:207,160,175...207,162,851

G

histidine ammonia lyase

affects expression

EXP

Raloxifene Hydrochloride affects the expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

hyaluronan and proteoglycan link protein 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of HAPLN1 mRNA

NCBI chr 2:22,366,967...22,431,709
Ensembl chr 2:22,366,967...22,429,098

G

hyaluronan synthase 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA

NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535

G

hemoglobin alpha, adult chain 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of HBA-A1 mRNA

NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,841,763...15,842,603

G

heparin-binding EGF-like growth factor

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of HBEGF mRNA; [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of HBEGF mRNA
Raloxifene Hydrochloride results in decreased expression of HBEGF mRNA

PMID:19059307 PMID:27017931

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

hemoglobin subunit gamma 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of HBG1 mRNA

NCBI chr 1:167,683,760...167,685,315
Ensembl chr 1:167,683,760...167,706,139

G

HMG-box transcription factor 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:54,256,864...54,283,366

G

heart development protein with EGF-like domains 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of HEG1 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA

PMID:14699072 PMID:19059307

NCBI chr11:80,512,096...80,600,150
Ensembl chr11:80,512,096...80,600,092

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HEY2 mRNA]

NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:28,641,057...28,651,187

G

hepatocyte growth factor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

hexokinase 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HK1 mRNA

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814

G

hemicentin 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of HMCN1 mRNA

NCBI chr13:65,165,532...65,634,681
Ensembl chr13:65,165,532...65,634,519

G

high mobility group AT-hook 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of HMGA2 mRNA

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341

G

high mobility group box 1

decreases expression
affects expression

ISO
EXP

Raloxifene Hydrochloride results in decreased expression of HMGB1 mRNA
Raloxifene Hydrochloride affects the expression of HMGB1 mRNA

PMID:16079270 PMID:16514628

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

heme oxygenase 1

multiple interactions
affects expression
decreases expression
increases expression

ISO
EXP

1,10-phenanthroline inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Copper promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; dimethyl sulfate inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Iron promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; MAP2K6 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 protein]; TEMPO inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]
Raloxifene Hydrochloride affects the expression of HMOX1 mRNA
Raloxifene Hydrochloride results in decreased expression of HMOX1 mRNA
Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA; Raloxifene Hydrochloride results in increased expression of HMOX1 protein

PMID:16079270 PMID:16298037 PMID:19059307 PMID:20888885

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hepatocyte nuclear factor 4, alpha

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA]

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

heterogeneous nuclear ribonucleoprotein A2/B1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HNRNPA2B1 mRNA

NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572

G

heterogeneous nuclear ribonucleoprotein H1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HNRNPH1 mRNA

NCBI chr10:35,187,412...35,203,909
Ensembl chr10:35,193,890...35,203,906

G

heterogeneous nuclear ribonucleoprotein U

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HNRNPU mRNA

NCBI chr13:92,609,791...92,618,580
Ensembl chr13:92,605,216...92,618,612

G

homer scaffold protein 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of HOMER2 mRNA

NCBI chr 1:144,968,207...145,069,022
Ensembl chr 1:144,976,436...145,068,997

G

homeobox A1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of HOXA1 mRNA

NCBI chr 4:82,586,505...82,589,209
Ensembl chr 4:82,586,505...82,589,209

G

hippocalcin-like 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

15-hydroxyprostaglandin dehydrogenase

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HPGD mRNA]

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831

G

hydroxysteroid (17-beta) dehydrogenase 11

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of HSD17B11 mRNA

NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,997,906...6,047,811

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression

EXP

Raloxifene Hydrochloride affects the expression of HSD17B4 mRNA

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

heat shock protein 90 alpha family class B member 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein 90 beta family member 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HSP90B1 mRNA

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 1A

affects expression
increases expression

ISO
EXP

Raloxifene Hydrochloride affects the expression of HSPA1A mRNA
Raloxifene Hydrochloride results in increased expression of HSPA1A protein

PMID:14699072 PMID:15860553

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of HSPA1B mRNA]
Raloxifene Hydrochloride affects the expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 4

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 8

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family B (small) member 8

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]

PMID:19059307 PMID:21185374

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

heat shock protein family D (Hsp60) member 1

decreases expression
affects expression

ISO
EXP

Raloxifene Hydrochloride results in decreased expression of HSPD1 mRNA
Raloxifene Hydrochloride affects the expression of HSPD1 mRNA

PMID:16079270 PMID:16514628

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

5-hydroxytryptamine receptor 2A

affects expression
multiple interactions

ISO
EXP

Raloxifene Hydrochloride affects the expression of HTR2A mRNA
Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]; Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]

PMID:14699072 PMID:17398000

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 3A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA

NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884

G

5-hydroxytryptamine receptor 5A

affects expression

EXP

Raloxifene Hydrochloride affects the expression of HTR5A mRNA

NCBI chr 4:8,178,802...8,188,485
Ensembl chr 4:8,178,802...8,200,482

G

intercellular adhesion molecule 1

multiple interactions

ISO

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 4

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ID4 mRNA

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
affects expression

ISO
EXP

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of IDH2 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of IDH2 mRNA]
Raloxifene Hydrochloride affects the expression of IDH2 mRNA

PMID:14699072 PMID:16079270 PMID:19059307

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

indoleamine 2,3-dioxygenase 1

multiple interactions
increases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
Raloxifene Hydrochloride results in increased expression of IDO1 mRNA

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328

G

immediate early response 3

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of IER3 mRNA
ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of IER3 mRNA]

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

interferon-induced protein with tetratricopeptide repeats 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of IFIT2 mRNA

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:241,515,709...241,521,798

G

interferon gamma receptor 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA

NCBI chr11:44,265,703...44,283,975
Ensembl chr11:44,265,703...44,283,975

G

interferon-related developmental regulator 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

insulin-like growth factor 1

multiple interactions
affects expression
increases expression
decreases expression

ISO
EXP

Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA1 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to IGF1 promoter]
Raloxifene Hydrochloride affects the expression of IGF1 mRNA
Raloxifene Hydrochloride results in increased expression of IGF1 mRNA
Raloxifene Hydrochloride results in decreased expression of IGF1 mRNA; Raloxifene Hydrochloride results in decreased expression of IGF1 protein

PMID:15762036 PMID:15978972 PMID:16912660 PMID:17645796 PMID:17872375 More...

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 2

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of IGF2 mRNA

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

insulin-like growth factor binding protein 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of IGFBP3 protein

PMID:15855258 PMID:16912660

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

insulin-like growth factor binding protein 4

affects expression

ISO

Raloxifene Hydrochloride affects the expression of IGFBP4 mRNA

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

insulin-like growth factor binding protein 6

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of IGFBP6 mRNA

NCBI chr 7:135,154,919...135,159,550
Ensembl chr 7:135,154,685...135,159,795

G

interleukin 10 receptor subunit alpha

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of IL10RA mRNA

NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028

G

interleukin 11

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915

G

interleukin 12A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of IL12A mRNA

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 13 receptor subunit alpha 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of IL13RA1 mRNA

NCBI chr X:120,213,670...120,294,777
Ensembl chr X:120,214,075...120,274,461

G

interleukin 1 beta

multiple interactions

ISO
EXP

[Raloxifene Hydrochloride co-treated with IL1B protein] results in increased expression of PTGDS mRNA; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL1B protein]

PMID:12072388 PMID:24722370 PMID:25305410

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of IL1R1 mRNA]

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 1 receptor accessory protein

affects expression

ISO

Raloxifene Hydrochloride affects the expression of IL1RAP mRNA

NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342

G

interleukin 4

multiple interactions

ISO
EXP

Raloxifene Hydrochloride inhibits the reaction [IL4 protein results in increased phosphorylation of STAT3 protein]
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of IL4 mRNA]

PMID:24080207 PMID:24456369

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 4 receptor

affects expression

ISO

Raloxifene Hydrochloride affects the expression of IL4R mRNA

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 6

decreases expression
decreases secretion
multiple interactions

ISO
EXP

Raloxifene Hydrochloride results in decreased expression of IL6 mRNA; Raloxifene Hydrochloride results in decreased expression of IL6 protein
Raloxifene Hydrochloride results in decreased secretion of IL6 protein
ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased secretion of IL6 protein]; Raloxifene Hydrochloride inhibits the reaction [[IL6R protein co-treated with IL6 protein] results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL6 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to IL6 protein] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:15579764 PMID:15762036 PMID:15953991 PMID:16298037 PMID:19533603 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [[IL6R protein co-treated with IL6 protein] results in increased phosphorylation of STAT3 protein]

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interleukin 6 cytokine family signal transducer

affects binding

ISO

Raloxifene Hydrochloride binds to IL6ST protein

PMID:24456369 PMID:32940862

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

interleukin 7 receptor

affects expression

ISO

Raloxifene Hydrochloride affects the expression of IL7R mRNA

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

inflammation and lipid regulator with UBA-like and NBR1-like domains

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ILRUN mRNA

NCBI chr20:5,811,721...5,878,082
Ensembl chr20:5,811,734...5,877,978

G

inhibin subunit beta A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

inositol polyphosphate-4-phosphatase type II B

affects expression

ISO

Raloxifene Hydrochloride affects the expression of INPP4B mRNA

NCBI chr19:42,824,710...43,575,039
Ensembl chr19:42,829,871...43,185,091

G

inositol polyphosphate-5-phosphatase A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA

NCBI chr 1:203,619,676...203,810,035
Ensembl chr 1:203,619,637...203,810,028

G

insulin 1

multiple interactions

ISO

IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]]; IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]]; IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]]; Raloxifene Hydrochloride affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin induced gene 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

IQ motif containing GTPase activating protein 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of IQGAP1 mRNA

NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:144,088,793...144,179,043

G

interferon regulatory factor 7

affects expression

EXP

Raloxifene Hydrochloride affects the expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

interferon stimulated exonuclease gene 20

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ISG20 mRNA
Raloxifene Hydrochloride affects the expression of ISG20 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401

G

integrin subunit beta 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ITGB1 mRNA

PMID:12154049 PMID:19429434

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ITGB3 mRNA

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

inositol 1,4,5-trisphosphate receptor, type 3

affects expression

ISO

Raloxifene Hydrochloride affects the expression of ITPR3 mRNA

NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184

G

involucrin

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of IVL mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of IVL mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578

G

jagged canonical Notch ligand 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872

G

Janus kinase 2

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]
Raloxifene Hydrochloride results in decreased expression of JAK2 mRNA

PMID:17272397 PMID:26865669

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

kazrin, periplakin interacting protein

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KAZN mRNA

NCBI chr 5:159,675,803...160,666,084
Ensembl chr 5:159,675,803...160,664,154

G

potassium voltage-gated channel subfamily D member 3

multiple interactions
decreases expression
decreases activity

EXP
ISO

Raloxifene Hydrochloride promotes the reaction [Fulvestrant results in decreased activity of KCND3 protein]
Raloxifene Hydrochloride results in decreased expression of KCND3 mRNA
[KCNIP2 protein co-treated with Raloxifene Hydrochloride] results in decreased activity of KCND3 protein
Raloxifene Hydrochloride results in decreased activity of KCND3 protein

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium voltage-gated channel subfamily E regulatory subunit 1

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of KCNE1 mRNA

NCBI chr11:45,066,875...45,080,024
Ensembl chr11:45,064,162...45,081,247

G

potassium voltage-gated channel subfamily H member 5

affects expression

EXP

Raloxifene Hydrochloride affects the expression of KCNH5 mRNA

NCBI chr 6:99,350,947...99,643,856
Ensembl chr 6:99,360,302...99,643,856

G

potassium voltage-gated channel interacting protein 2

multiple interactions

ISO

[KCNIP2 protein co-treated with Raloxifene Hydrochloride] results in decreased activity of KCND3 protein

NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:254,590,175...254,613,898

G

potassium calcium-activated channel subfamily N member 4

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA
Raloxifene Hydrochloride affects the expression of KCNN4 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275

G

potassium channel tetramerization domain containing 12

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA
Raloxifene Hydrochloride affects the expression of KCTD12 mRNA

PMID:14699072 PMID:19059307

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

kinesin family member 20A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 3C

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA

NCBI chr 6:32,086,879...32,125,812
Ensembl chr 6:32,086,124...32,126,066

G

KiSS-1 metastasis-suppressor

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of KISS1 mRNA

NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906

G

KLF transcription factor 10

affects expression

ISO

Raloxifene Hydrochloride affects the expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

KLF transcription factor 6

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of KLF6 mRNA

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601

G

kelch-like family member 24

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

killer cell lectin like receptor C1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of KLRC1 mRNA

NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:164,828,163...164,838,464

G

killer cell lectin like receptor C2

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of KLRC2 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC2 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of KLRC2 mRNA]

PMID:14699072 PMID:19059307

NCBI chr 4:164,808,722...164,819,865
Ensembl chr 4:164,808,722...164,819,865

G

killer cell lectin like receptor C3

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to KLRC3 gene]

PMID:17395694 PMID:19059307

NCBI chr 4:164,791,102...164,798,758
Ensembl chr 4:164,791,128...164,798,758

G

killer cell lectin like receptor K1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA

NCBI chr 4:164,767,377...164,778,453
Ensembl chr 4:164,767,946...164,778,382

G

karyopherin subunit alpha 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of KPNA2 mRNA

NCBI chr10:92,433,678...92,445,841
Ensembl chr10:92,433,679...92,445,937

G

karyopherin subunit beta 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of KPNB1 mRNA

NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,642,082...82,670,856

G

keratin 17

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT17 mRNA

NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,679,070...85,683,787

G

keratin 34

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT34 mRNA

NCBI chr10:85,470,391...85,474,501
Ensembl chr10:85,470,391...85,474,501

G

L3MBTL histone methyl-lysine binding protein 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of L3MBTL1 mRNA

NCBI chr 3:172,014,774...172,053,181
Ensembl chr 3:172,021,416...172,053,181

G

laminin subunit beta 1

multiple interactions

ISO

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LAMB1 mRNA

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760

G

laminin subunit gamma 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of LAMC1 mRNA

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986

G

LBH regulator of WNT signaling pathway

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LBH mRNA

NCBI chr 6:28,321,040...28,344,855
Ensembl chr 6:28,321,040...28,370,238

G

lipocalin 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of LCN2 mRNA

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

low density lipoprotein receptor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

low density lipoprotein receptor class A domain containing 4

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA

NCBI chr18:63,789,089...64,118,166
Ensembl chr18:63,790,440...64,113,064

G

leptin receptor

affects expression

EXP

Raloxifene decreases Lepr protein expression in adipose tissue at 7 weeks and increases it at 22 weeks

RGD

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

leucine rich repeat containing G protein coupled receptor 5

multiple interactions

ISO

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 protein

NCBI chr 7:52,973,151...53,107,964
Ensembl chr 7:52,974,332...53,108,163

G

luteinizing hormone subunit beta

multiple interactions
decreases secretion

EXP

Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]
Raloxifene Hydrochloride results in decreased secretion of LHB protein

PMID:17398000 PMID:27395752

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIF, interleukin 6 family cytokine

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of LIF mRNA
Raloxifene Hydrochloride results in decreased expression of LIF mRNA

PMID:26603317 PMID:27017931

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

LIM and calponin homology domains 1

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of LIMCH1 mRNA]

NCBI chr14:41,466,433...41,779,477
Ensembl chr14:41,466,433...41,778,837

G

lipase H

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LIPH mRNA

NCBI chr11:92,536,724...92,586,117
Ensembl chr11:92,537,860...92,586,120

G

LIM and cysteine-rich domains 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA

NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875

G

lamin B2

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of LMNB2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:9,443,308...9,459,468
Ensembl chr 7:9,440,128...9,459,342

G

lysyl oxidase

affects expression

EXP

Raloxifene Hydrochloride affects the expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

lipoprotein lipase

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of LPL mRNA
Raloxifene Hydrochloride results in increased expression of LPL mRNA

PMID:16643890 PMID:19059307

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine-rich repeats and immunoglobulin-like domains 1

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA
Raloxifene Hydrochloride affects the expression of LRIG1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 4:128,687,723...128,788,219
Ensembl chr 4:128,687,723...128,788,219

G

leucine rich repeat containing 20

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA

NCBI chr20:29,965,673...30,071,185
Ensembl chr20:29,972,001...30,071,184

G

lymphotoxin beta

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of LTB mRNA

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054

G

latent transforming growth factor beta binding protein 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of LTBP1 mRNA

NCBI chr 6:25,781,625...26,177,346
Ensembl chr 6:25,781,638...26,454,036

G

lumican

affects expression

ISO

Raloxifene Hydrochloride affects the expression of LUM mRNA

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:34,245,360...34,252,508

G

lymphocyte antigen 6 complex, locus I

affects expression

EXP

Raloxifene Hydrochloride affects the expression of LY6B mRNA

NCBI chr 7:108,943,081...108,948,499
Ensembl chr 7:108,943,081...108,945,889

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LYN mRNA

NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461

G

LysM domain containing 4

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA

NCBI chr 1:130,249,340...130,255,357
Ensembl chr 1:130,249,479...130,255,357

G

macroH2A.1 histone

affects expression

EXP

Raloxifene Hydrochloride affects the expression of MACROH2A1 mRNA

NCBI chr17:8,484,340...8,547,268
Ensembl chr17:8,484,246...8,547,257

G

MAF bZIP transcription factor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MAF mRNA

NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378

G

MAF bZIP transcription factor F

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

mannosidase, alpha, class 2A, member 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of MAN2A2 mRNA

NCBI chr 1:143,712,157...143,736,624
Ensembl chr 1:143,716,072...143,736,562

G

monoamine oxidase A

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [MAOA protein results in increased metabolism of psilocin]

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases lipidation

ISO

[Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased lipidation of MAP1LC3B protein
Raloxifene Hydrochloride results in increased lipidation of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase kinase 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen-activated protein kinase kinase 6

multiple interactions

ISO

MAP2K6 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 protein]

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen-activated protein kinase kinase kinase 11

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MAP3K11 mRNA

NCBI chr 1:212,404,685...212,417,986
Ensembl chr 1:212,403,680...212,417,983

G

mitogen-activated protein kinase kinase kinase 20

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of MAP3K20 mRNA

NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA

NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO
EXP

U 0126 inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]; Raloxifene Hydrochloride inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK1 protein]; sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]

PMID:15712295 PMID:16798746 PMID:17174166 PMID:20945400 PMID:24782323 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

affects expression

EXP

Raloxifene Hydrochloride affects the expression of MAPK14 mRNA

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO
EXP

4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]; Raloxifene Hydrochloride inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK3 protein]; sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]

PMID:15712295 PMID:16798746 PMID:17174166 PMID:20945400 PMID:24782323 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MAPK activated protein kinase 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA

NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326

G

MARCKS-like 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of MARCKSL1 mRNA

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:147,134,514...147,138,417

G

matrin 3

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of MATR3 mRNA

NCBI chr18:27,428,190...27,474,421
Ensembl chr18:27,432,179...27,470,421

G

muscleblind-like splicing regulator 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

mast cell protease 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of MCPT1 mRNA

NCBI chr15:33,841,606...33,844,174
Ensembl chr15:33,841,606...33,844,174

G

mast cell protease 4

affects expression

EXP

Raloxifene Hydrochloride affects the expression of MCPT4 mRNA

NCBI chr15:33,471,491...33,474,112
Ensembl chr15:33,471,491...33,474,110

G

multiple C2 and transmembrane domain containing 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MCTP1 mRNA

NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:7,803,382...8,493,596

G

MyoD family inhibitor domain containing

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of MDFIC mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA

PMID:14699072 PMID:19059307

NCBI chr 4:44,938,301...45,018,157
Ensembl chr 4:44,938,480...45,018,156

G

MDM2 proto-oncogene

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

myocyte enhancer factor 2a

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162

G

microfibril associated protein 5

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MFAP5 mRNA]
Raloxifene Hydrochloride affects the expression of MFAP5 mRNA

NCBI chr 4:157,399,919...157,422,448
Ensembl chr 4:157,395,597...157,422,448

G

matrix Gla protein

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MGP mRNA]
Raloxifene Hydrochloride results in decreased expression of MGP mRNA

PMID:16514628 PMID:21185374

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859

G

microtubule associated monooxygenase, calponin and LIM domain containing 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of MICAL2 mRNA

NCBI chr 1:175,780,441...175,965,157
Ensembl chr 1:175,825,596...175,905,155

G

midline 1

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of MID1 mRNA]

NCBI chr X:27,678,248...28,053,049
Ensembl chr X:27,681,867...27,906,105

G

marker of proliferation Ki-67

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

monocyte to macrophage differentiation-associated 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MMD2 mRNA

NCBI chr12:17,075,870...17,123,255
Ensembl chr12:17,076,260...17,123,904

G

matrix metallopeptidase 12

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of MMP12 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA

PMID:14699072 PMID:19059307

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478

G

matrix metallopeptidase 13

multiple interactions

EXP

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of MMP13 mRNA]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

affects expression
multiple interactions

EXP
ISO

Raloxifene Hydrochloride affects the expression of MMP2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]]; ESR2 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]]; Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]

PMID:16079270 PMID:23471663

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 3

multiple interactions

EXP

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of MMP3 mRNA]

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

decreases activity
multiple interactions
increases expression
decreases expression

ISO
EXP

Raloxifene Hydrochloride results in decreased activity of MMP9 protein
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride] affects the expression of MMP9 protein
Raloxifene Hydrochloride results in increased expression of MMP9 mRNA
Raloxifene Hydrochloride results in decreased expression of MMP9 mRNA

PMID:17582780 PMID:22841776 PMID:31332895

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MN1 proto-oncogene, transcriptional regulator

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MN1 mRNA

NCBI chr12:50,841,632...50,880,795
Ensembl chr12:50,841,632...50,880,795

G

myeloperoxidase

multiple interactions

EXP

Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallophosphoesterase domain containing 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA

NCBI chr 3:113,635,614...113,810,307
Ensembl chr 3:113,635,407...113,811,783

G

major histocompatibility complex, class I-related

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

mitochondrial ribosomal protein L33

affects expression

ISO

Raloxifene Hydrochloride affects the expression of MRPL33 mRNA

NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987

G

microseminoprotein, beta

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of MSMB mRNA; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MSMB mRNA]
Raloxifene Hydrochloride affects the expression of MSMB mRNA

PMID:14699072 PMID:19059307

NCBI chr16:7,372,803...7,393,406
Ensembl chr16:7,372,819...7,393,405

G

macrophage stimulating 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MST1 mRNA

NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015

G

metallothionein 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

methylenetetrahydrofolate reductase

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

mechanistic target of rapamycin kinase

increases phosphorylation

ISO

Raloxifene Hydrochloride results in increased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

mucin 1, cell surface associated

increases expression
affects expression

ISO
EXP

Raloxifene Hydrochloride results in increased expression of MUC1 protein
Raloxifene Hydrochloride affects the expression of MUC1 mRNA

PMID:16012748 PMID:16079270

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491

G

MYB proto-oncogene, transcription factor

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MYB mRNA]
Raloxifene Hydrochloride results in decreased expression of MYB mRNA

PMID:21185374 PMID:26865669

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYB proto-oncogene like 1

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of MYBL1 mRNA
Raloxifene Hydrochloride results in decreased expression of MYBL1 mRNA

PMID:21185374 PMID:26865669

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
decreases expression

ISO

GPER1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of MYC mRNA]; Raloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]
Raloxifene Hydrochloride results in decreased expression of MYC mRNA; Raloxifene Hydrochloride results in decreased expression of MYC protein

PMID:16497877 PMID:20945400 PMID:22453024 PMID:26502914

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin light chain 9

affects expression

EXP

Raloxifene Hydrochloride affects the expression of MYL9 mRNA

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myosin X

affects expression

ISO

Raloxifene Hydrochloride affects the expression of MYO10 mRNA

NCBI chr 2:77,831,532...78,036,137
Ensembl chr 2:77,831,532...78,036,137

G

myogenic differentiation 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

myelin transcription factor 1-like

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA

NCBI chr 6:51,892,858...52,291,830
Ensembl chr 6:52,155,754...52,291,828

G

Ngfi-A binding protein 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NAB1 mRNA

NCBI chr 9:56,545,547...56,585,045
Ensembl chr 9:56,545,729...56,614,210

G

asparaginyl-tRNA synthetase 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of NARS1 mRNA

NCBI chr18:60,259,506...60,275,782
Ensembl chr18:60,259,516...60,275,782

G

neuron navigator 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA

NCBI chr 1:107,799,968...108,458,546
Ensembl chr 1:107,805,096...108,458,546

G

NBL1, DAN family BMP antagonist

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of NBL1 mRNA

NCBI chr 5:156,601,986...156,613,182
Ensembl chr 5:156,601,986...156,613,186

G

non-SMC condensin I complex, subunit H

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502

G

neutrophil cytosolic factor 2

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of NCF2 mRNA]
Raloxifene Hydrochloride affects the expression of NCF2 mRNA

PMID:14699072 PMID:19059307

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

nucleolin

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of NCL mRNA

NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083

G

nuclear receptor coactivator 1

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; Raloxifene Hydrochloride promotes the reaction [NCOA1 protein binds to IGF1 promoter]
Raloxifene Hydrochloride results in increased expression of NCOA1 mRNA

PMID:17872375 PMID:19059307 PMID:19432593

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

nuclear receptor coactivator 2

multiple interactions
increases expression

ISO

Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to PTGS2 promoter]
Raloxifene Hydrochloride results in increased expression of NCOA2 protein

PMID:16739346 PMID:17872375

NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776

G

nuclear receptor coactivator 3

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to PTGS2 promoter]

PMID:17395694 PMID:17872375

NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631

G

nuclear receptor coactivator 4

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of NCOA4 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840

G

nuclear receptor co-repressor 2

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to PTGS2 promoter]
Raloxifene Hydrochloride results in decreased expression of NCOR2 mRNA

PMID:17872375 PMID:19432593

NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612

G

NDRG family member 4

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA

NCBI chr19:9,357,470...9,393,465
Ensembl chr19:9,357,470...9,392,972

G

NADH:ubiquinone oxidoreductase subunit A2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of NDUFA2 mRNA

NCBI chr18:28,629,795...28,631,884
Ensembl chr18:28,629,795...28,631,884

G

nectin cell adhesion molecule 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of NECTIN1 mRNA

NCBI chr 8:52,998,662...53,061,745
Ensembl chr 8:52,998,662...53,086,664

G

neurofilament light chain

affects expression

ISO

Raloxifene Hydrochloride affects the expression of NEFL mRNA

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

NIMA-related kinase 7

affects expression

ISO

Raloxifene Hydrochloride affects the expression of NEK7 mRNA

NCBI chr13:52,573,730...52,700,869
Ensembl chr13:52,573,730...52,700,823

G

neurofibromin 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of NFE2L1 mRNA

NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375

G

nuclear factor, interleukin 3 regulated

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of NFIL3 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA

PMID:14699072 PMID:19059307

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

Raloxifene Hydrochloride promotes the reaction [NFKB1 protein binds to SLC1A2 promoter]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions
affects expression
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA
Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Raloxifene Hydrochloride affects the expression of NFKBIA mRNA
Raloxifene Hydrochloride results in decreased expression of NFKBIA mRNA

PMID:14699072 PMID:16298037 PMID:19059307 PMID:31470850

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor epsilon

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

NHERF family PDZ scaffold protein 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of NHERF1 mRNA

NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579

G

ninjurin 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 6

affects expression

EXP

Raloxifene Hydrochloride affects the expression of NME6 mRNA

NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:118,711,036...118,718,288

G

nicotinamide riboside kinase 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of NMRK1 mRNA

NCBI chr 1:225,475,975...225,503,414
Ensembl chr 1:225,475,830...225,503,602

G

nitric oxide synthase 2

multiple interactions
decreases expression

ISO
EXP

[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein; [Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Cycloheximide inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; Dactinomycin inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; Fulvestrant inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]
Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NOS2 protein]

PMID:15860553 PMID:20888885 PMID:28138957

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 3

affects expression

ISO

Raloxifene Hydrochloride affects the expression of NOTCH3 mRNA

NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778

G

nucleophosmin 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of NPM1 mRNA

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

natriuretic peptide receptor 2

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of NPR2 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 5:62,678,197...62,697,360
Ensembl chr 5:62,678,367...62,697,343

G

neuropeptide Y receptor Y1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of NPY1R mRNA]

NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of NQO1 protein
ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group D, member 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 2, group F, member 6

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of NR2F6 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:18,080,003...18,087,449
Ensembl chr16:18,080,003...18,087,449

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

neuronal regeneration related protein

affects expression

ISO

Raloxifene Hydrochloride affects the expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

nuclear respiratory factor 1

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NRF1 mRNA]; Vehicle Emissions inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NRF1 mRNA]

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

neuregulin 1

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neuregulin 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of NRG2 mRNA

NCBI chr18:27,890,578...28,072,538
Ensembl chr18:27,890,578...28,072,538

G

NUAK family kinase 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of NUAK1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:21,217,729...21,289,608
Ensembl chr 7:21,217,681...21,289,354

G

nucleoporin 160

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of NUP160 mRNA

NCBI chr 3:97,120,723...97,183,227
Ensembl chr 3:97,121,628...97,180,720

G

NUS1 dehydrodolichyl diphosphate synthase subunit

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of NUS1 mRNA

NCBI chr20:32,354,519...32,381,265
Ensembl chr20:32,354,439...32,381,264

G

nuclear RNA export factor 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of NXF1 mRNA

NCBI chr 1:215,084,563...215,097,756
Ensembl chr 1:215,084,099...215,097,756

G

occludin

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of OCLN mRNA

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

olfactomedin 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of OLFM1 mRNA

NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:31,918,573...31,956,260

G

olfactomedin-like 2A

affects expression

ISO

Raloxifene Hydrochloride affects the expression of OLFML2A mRNA

NCBI chr 3:43,098,299...43,127,621
Ensembl chr 3:43,098,299...43,127,621

G

olfactory receptor family 10 subfamily AL member 6

affects expression

EXP

Raloxifene Hydrochloride affects the expression of OR10AL6 mRNA

NCBI chr20:743,522...744,487
Ensembl chr20:743,522...816,076

G

olfactory receptor family 1 subfamily F member 45

affects expression

EXP

Raloxifene Hydrochloride affects the expression of OR1F45 mRNA

NCBI chr10:12,497,516...12,498,457
Ensembl chr10:12,497,516...12,498,457

G

oxysterol binding protein-like 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA

NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169

G

oxysterol binding protein-like 7

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of OSBPL7 mRNA

NCBI chr10:82,532,335...82,549,999
Ensembl chr10:82,532,411...82,549,999

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA
Raloxifene Hydrochloride results in decreased expression of OTUB2 mRNA

PMID:19059307 PMID:33269387

NCBI chr 6:128,309,863...128,328,444
Ensembl chr 6:128,299,693...128,328,433

G

OTU deubiquitinase 1

multiple interactions

ISO

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD1 mRNA

NCBI chr17:87,168,248...87,171,098
Ensembl chr17:87,149,175...87,330,706

G

OTU deubiquitinase 3

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of OTUD3 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of OTUD3 mRNA

NCBI chr 5:156,419,099...156,445,341
Ensembl chr 5:156,423,332...156,445,540

G

OTU deubiquitinase 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of OTUD5 mRNA

NCBI chr X:17,296,750...17,331,257
Ensembl chr X:17,298,029...17,331,054

G

OTU deubiquitinase 7A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of OTUD7A mRNA

NCBI chr 1:126,476,275...126,800,037
Ensembl chr 1:126,693,712...126,799,301

G

OTU deubiquitinase 7B

multiple interactions
increases expression

ISO

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD7B mRNA
Raloxifene Hydrochloride results in increased expression of OTUD7B mRNA

NCBI chr 2:186,350,811...186,411,461
Ensembl chr 2:186,350,798...186,409,440

G

purinergic receptor P2Y14

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]

NCBI chr 2:145,522,598...145,563,074
Ensembl chr 2:145,516,390...145,564,788

G

palladin, cytoskeletal associated protein

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PALLD mRNA

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:33,238,956...33,632,232

G

poly (A) polymerase alpha

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PAPOLA mRNA

NCBI chr 6:130,446,236...130,499,371
Ensembl chr 6:130,446,797...130,499,336

G

pappalysin 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PAPPA mRNA

NCBI chr 5:83,513,358...83,751,364
Ensembl chr 5:83,513,358...83,751,361

G

Parkinsonism associated deglycase

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PARK7 mRNA

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

Raloxifene Hydrochloride results in increased cleavage of PARP1 protein
[ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pro-apoptotic WT1 regulator

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PAWR mRNA; Raloxifene Hydrochloride results in increased expression of PAWR protein

NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492

G

paired box 5

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PAX5 mRNA

NCBI chr 5:63,554,784...63,741,380
Ensembl chr 5:63,560,722...63,739,987

G

protocadherin 7

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA

NCBI chr14:56,684,817...57,114,976
Ensembl chr14:56,687,725...57,112,665

G

protocadherin gamma subfamily A, 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PCDHGA3 mRNA

NCBI chr18:29,750,383...29,919,095

G

PCNA clamp associated factor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PCLAF mRNA

NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:75,315,707...75,328,106

G

proliferating cell nuclear antigen

increases expression
multiple interactions
affects expression
decreases expression

ISO
EXP

Raloxifene Hydrochloride results in increased expression of PCNA protein
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PCNA protein
Raloxifene Hydrochloride affects the expression of PCNA protein
Raloxifene Hydrochloride results in decreased expression of PCNA protein

PMID:15731164 PMID:16009171 PMID:17220163 PMID:24431404

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

procollagen C-endopeptidase enhancer

affects expression
increases expression

EXP

Raloxifene Hydrochloride affects the expression of PCOLCE mRNA
Raloxifene Hydrochloride results in increased expression of PCOLCE mRNA

PMID:15576828 PMID:16079270

NCBI chr12:24,720,972...24,727,287
Ensembl chr12:24,720,936...24,727,287

G

phosphatidylcholine transfer protein

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432

G

programmed cell death 5

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PDCD5 mRNA

NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:97,442,755...97,449,844

G

phosphodiesterase 3B

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PDE3B mRNA

NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503

G

phosphodiesterase 4D

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PDE4D mRNA

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569

G

phosphodiesterase 5A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PDE5A mRNA

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

platelet derived growth factor receptor alpha

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PDGFRA mRNA

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516

G

platelet derived growth factor receptor beta

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PDGFRB mRNA

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

PDZ and LIM domain 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA

NCBI chr16:53,085,020...53,116,495
Ensembl chr16:53,085,020...53,116,217

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PDP1 mRNA

NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960

G

prodynorphin

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

PDZ domain containing 1

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA]
Raloxifene Hydrochloride results in decreased expression of PDZK1 mRNA

PMID:21185374 PMID:26865669

NCBI chr 2:187,064,995...187,096,348
Ensembl chr 2:187,065,013...187,096,806

G

period circadian regulator 2

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of PER2 mRNA]

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

peroxisomal biogenesis factor 5

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PEX5 mRNA

NCBI chr 4:158,956,973...158,983,581
Ensembl chr 4:158,956,974...158,982,733

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

progesterone receptor

multiple interactions
decreases expression
increases expression

ISO
EXP

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA; [trichostatin A co-treated with Raloxifene Hydrochloride] results in decreased expression of PGR mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; trichostatin A inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA]
[Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of PGR mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]
Raloxifene Hydrochloride results in decreased expression of PGR mRNA; Raloxifene Hydrochloride results in decreased expression of PGR protein
Raloxifene Hydrochloride results in increased expression of PGR protein

PMID:11867264 PMID:16837883 PMID:16973256 PMID:21185374 PMID:22476901 More...

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

polyhomeotic homolog 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA

NCBI chr 5:146,285,000...146,383,664
Ensembl chr 5:146,285,008...146,383,663

G

PHD finger protein 11

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA

NCBI chr15:37,568,090...37,592,490
Ensembl chr15:37,568,090...37,591,016

G

PH domain and leucine rich repeat protein phosphatase 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PHLPP mRNA

NCBI chr13:22,823,132...23,045,619
Ensembl chr13:22,823,132...23,045,619

G

protein inhibitor of activated STAT, 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PIAS3 mRNA

NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:186,921,428...186,936,714

G

phosphatidylinositol glycan anchor biosynthesis, class N

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PIGN mRNA

NCBI chr13:22,173,670...22,321,344
Ensembl chr13:22,176,576...22,321,379

G

polymeric immunoglobulin receptor

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PIGR mRNA

NCBI chr13:44,851,001...44,879,143
Ensembl chr13:44,851,182...44,879,141

G

phosphoinositide-3-kinase regulatory subunit 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PIK3R3 mRNA

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762

G

Pim-1 proto-oncogene, serine/threonine kinase

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PIM1 mRNA

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764

G

phosphatidylinositol transfer protein, cytoplasmic 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA

NCBI chr10:92,663,260...92,928,616
Ensembl chr10:92,663,260...92,928,344

G

phospholipase A2, group X

multiple interactions

ISO

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of PLA2G10 mRNA]

NCBI chr10:2,104,927...2,117,998
Ensembl chr10:2,104,927...2,116,172

G

phospholipase A2 group VII

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PLA2G7 mRNA

NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747

G

plasminogen activator, tissue type

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PLAT protein

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

plasminogen activator, urokinase

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of PLAU mRNA
Raloxifene Hydrochloride results in decreased expression of PLAU protein

PMID:16277677 PMID:19059307

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PLAUR mRNA; Raloxifene Hydrochloride results in decreased expression of PLAUR protein

PMID:16277677 PMID:26865669

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

pleckstrin homology and FYVE domain containing 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PLEKHF2 mRNA

NCBI chr 5:28,888,358...28,905,350
Ensembl chr 5:28,868,469...28,923,514

G

pleckstrin homology domain containing S1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PLEKHS1 mRNA

NCBI chr 1:265,500,524...265,533,352
Ensembl chr 1:265,500,830...265,533,350

G

polo-like kinase 3

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA]

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

phospholipid phosphatase 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PLPP1 mRNA

NCBI chr 2:46,172,202...46,233,632
Ensembl chr 2:46,172,197...46,234,676

G

phospholipid phosphatase 3

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of PLPP3 mRNA
ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of PLPP3 mRNA]

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667

G

plexin D1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PLXND1 mRNA

NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:150,675,377...150,715,566

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

peripheral myelin protein 22

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of PMP22 mRNA]

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940

G

PMS1 homolog 2, mismatch repair system component

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PMS2 mRNA

NCBI chr12:15,790,478...15,814,790
Ensembl chr12:15,790,478...15,815,248

G

podocalyxin-like

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PODXL mRNA

NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:61,102,419...61,149,789

G

DNA polymerase mu

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of POLM mRNA

NCBI chr14:84,921,039...84,930,649
Ensembl chr14:84,921,045...84,930,622

G

RNA polymerase II subunit B

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of POLR2B mRNA

NCBI chr14:31,151,534...31,189,222
Ensembl chr14:31,151,390...31,189,222

G

periostin

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of POSTN mRNA; Raloxifene Hydrochloride results in decreased expression of POSTN protein

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO

IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

protein phosphatase 1, regulatory subunit 10

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PPP1R10 mRNA

NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,827,802...2,842,418

G

protein phosphatase 1, regulatory subunit 13B

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PPP1R13B mRNA

NCBI chr 6:136,711,834...136,785,068
Ensembl chr 6:136,711,834...136,785,113

G

protein phosphatase 1, regulatory subunit 15A

increases expression
affects expression

ISO
EXP

Raloxifene Hydrochloride results in increased expression of PPP1R15A mRNA
Raloxifene Hydrochloride affects the expression of PPP1R15A mRNA

PMID:16079270 PMID:16497877

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

peroxiredoxin 2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

protein kinase C, zeta

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

prolactin

multiple interactions
decreases secretion

ISO

[Raloxifene Hydrochloride co-treated with Dopamine] results in decreased expression of PRL protein; Raloxifene Hydrochloride inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased secretion of PRL protein]
Raloxifene Hydrochloride results in decreased secretion of PRL protein

PMID:15950373 PMID:17054466 PMID:30865525

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protein C, inactivator of coagulation factors Va and VIIIa

decreases activity

ISO

Raloxifene Hydrochloride results in decreased activity of PROC protein

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

protein S

affects expression
decreases expression

ISO

Raloxifene Hydrochloride affects the expression of PROS1 protein
Raloxifene Hydrochloride results in decreased expression of PROS1 protein

PMID:15850603 PMID:16202731

NCBI chr11:13,676,310...13,757,858
Ensembl chr11:13,676,769...13,757,852

G

pre-mRNA processing factor 4B

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PRP4K mRNA

NCBI chr17:30,190,721...30,230,153
Ensembl chr17:30,193,907...30,225,420

G

serine protease 23

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PRSS23 mRNA

NCBI chr 1:152,815,301...152,835,005
Ensembl chr 1:152,813,670...152,947,871

G

prosaposin

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PSAP mRNA

NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,757,181...28,783,421

G

proteasome 26S subunit, non-ATPase 14

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PSMD14 mRNA

NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665

G

proteasome 26S subunit, non-ATPase 6

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PSMD6 mRNA

NCBI chr15:13,532,675...13,542,682
Ensembl chr15:13,532,675...13,542,682

G

proteasome activator subunit 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PSME1 mRNA

NCBI chr15:33,038,962...33,041,849
Ensembl chr15:33,038,597...33,041,848

G

proteasome activator subunit 4

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PSME4 mRNA

NCBI chr14:108,706,643...108,810,330
Ensembl chr14:108,706,643...108,810,328

G

prostaglandin D2 synthase

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with IL1B protein] results in increased expression of PTGDS mRNA

NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978

G

prostaglandin E receptor 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA

NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846

G

prostaglandin E synthase

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGES mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGES mRNA
Raloxifene Hydrochloride results in decreased expression of PTGES mRNA

PMID:19059307 PMID:24431404 PMID:26865669

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin F2 receptor inhibitor

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PTGFRN mRNA

NCBI chr 2:191,158,166...191,233,432
Ensembl chr 2:191,158,166...191,234,115

G

prostaglandin I2 synthase

affects expression

EXP

Raloxifene Hydrochloride affects the expression of PTGIS mRNA

NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

ISO
EXP

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to PTGS2 promoter]
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 protein
Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased expression of PTGS2 protein]
Raloxifene Hydrochloride results in decreased expression of PTGS2 mRNA
Raloxifene Hydrochloride results in increased expression of PTGS2 mRNA

PMID:15860553 PMID:17549036 PMID:17872375 PMID:19059307 PMID:24431404

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of PTH protein

NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:176,943,102...176,946,034

G

protein tyrosine phosphatase 4A3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA

NCBI chr 7:107,518,220...107,549,949
Ensembl chr 7:107,541,047...107,549,949

G

protein tyrosine phosphatase, non-receptor type 13

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PTPN13 mRNA

NCBI chr14:6,412,841...6,587,238
Ensembl chr14:6,412,841...6,587,171

G

protein tyrosine phosphatase, non-receptor type 4

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PTPN4 mRNA

NCBI chr13:33,324,808...33,504,957
Ensembl chr13:33,324,808...33,504,957

G

protein tyrosine phosphatase, non-receptor type 6

decreases activity

ISO

Raloxifene Hydrochloride results in decreased activity of PTPN6 protein

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

protein tyrosine phosphatase, receptor type, E

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of PTPRE mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PTPRE mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:199,774,195...199,924,646
Ensembl chr 1:199,774,198...199,922,242

G

protein tyrosine phosphatase, receptor type, H

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PTPRH mRNA

NCBI chr 1:78,272,414...78,318,977
Ensembl chr 1:78,271,276...78,318,977

G

protein tyrosine phosphatase, receptor type, R

affects expression

ISO

Raloxifene Hydrochloride affects the expression of PTPRR mRNA

NCBI chr 7:53,548,611...53,815,632
Ensembl chr 7:53,548,629...53,815,629

G

pentraxin 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

peptide YY

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of PYY mRNA

NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206

G

QKI, KH domain containing RNA binding

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of QKI mRNA

NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:52,935,382...53,047,337

G

RAB11B, member RAS oncogene family

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of RAB11B mRNA

NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756

G

RAB2A, member RAS oncogene family

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of RAB2A mRNA

NCBI chr 5:26,473,424...26,537,441
Ensembl chr 5:26,473,548...26,538,488

G

RAB31, member RAS oncogene family

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RAB31 mRNA

NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:112,693,597...112,828,092

G

Rab40c, member RAS oncogene family

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of RAB40C mRNA

NCBI chr10:15,405,436...15,440,659

G

Rac GTPase-activating protein 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RACGAP1 mRNA

NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:132,620,595...132,659,738

G

ral guanine nucleotide dissociation stimulator like 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA

NCBI chr13:67,184,402...67,454,019
Ensembl chr13:67,184,402...67,454,019

G

RAP1A, member of RAS oncogene family

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RAP1A mRNA

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808

G

Rap guanine nucleotide exchange factor like 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RAPGEFL1 mRNA

NCBI chr10:84,289,980...84,306,614
Ensembl chr10:84,289,980...84,306,614

G

retinoic acid receptor, alpha

affects expression

EXP

Raloxifene Hydrochloride affects the expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

RAS p21 protein activator 1

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of RASA1 mRNA

NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161

G

RAS and EF hand domain containing

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RASEF mRNA

NCBI chr 5:92,595,148...92,665,526
Ensembl chr 5:92,595,148...92,666,117

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RASGRF1 mRNA

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

RAS guanyl releasing protein 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA

NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434

G

RB transcriptional corepressor 1

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of RB1 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of RB1 protein

PMID:19429434 PMID:26660119

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RB binding protein 7, chromatin remodeling factor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RBBP7 mRNA

NCBI chr X:35,544,873...35,563,030
Ensembl chr X:35,544,873...35,563,030

G

RB binding protein 8, endonuclease

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RBBP8 mRNA

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:3,197,310...3,263,985

G

RB transcriptional corepressor like 1

decreases phosphorylation

ISO

Raloxifene Hydrochloride results in decreased phosphorylation of RBL1 protein

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

RNA binding motif protein 10

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of RBM10 mRNA

NCBI chr X:4,093,914...4,126,060
Ensembl chr X:4,093,914...4,126,060

G

regulator of calcineurin 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA

NCBI chr 9:24,456,861...24,674,234
Ensembl chr 9:24,456,861...24,672,189

G

RNA terminal phosphate cyclase-like 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RCL1 mRNA

NCBI chr 1:236,238,078...236,282,597
Ensembl chr 1:236,238,031...236,315,894

G

REST corepressor 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA

NCBI chr13:106,156,166...106,196,542
Ensembl chr13:106,157,232...106,196,575

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases activity

ISO
EXP

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]]; Raloxifene Hydrochloride affects the localization of and results in decreased activity of RELA protein; Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to RELA protein]; Raloxifene Hydrochloride inhibits the reaction [RELA protein binds to CCL3 promoter]; Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]
Raloxifene Hydrochloride results in decreased activity of RELA protein
Raloxifene Hydrochloride promotes the reaction [RELA protein binds to SLC1A2 promoter]; Raloxifene Hydrochloride promotes the reaction [TERT protein binds to RELA protein]

PMID:15590986 PMID:16497877 PMID:16798746 PMID:24722370 PMID:24782323 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RAS-like, estrogen-regulated, growth-inhibitor

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of RERG mRNA]

NCBI chr 4:171,712,794...171,821,268
Ensembl chr 4:171,712,794...171,820,903

G

ret proto-oncogene

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RET mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RET mRNA
Raloxifene Hydrochloride results in decreased expression of RET mRNA

PMID:19059307 PMID:26865669

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556

G

reticulophagy regulator 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA

NCBI chr 2:78,045,435...78,205,316
Ensembl chr 2:78,066,031...78,225,356

G

riboflavin kinase

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of RFK mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RFK mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:224,226,632...224,234,185
Ensembl chr 1:224,226,628...224,235,698
Ensembl chr X:224,226,628...224,235,698

G

raftlin lipid raft linker 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA

NCBI chr 9:18,302,143...18,499,819
Ensembl chr 9:18,285,934...18,499,819

G

regulator of G-protein signaling 10

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RGS10 mRNA

NCBI chr 1:192,376,772...192,422,640
Ensembl chr 1:192,376,774...192,418,904

G

regulator of G-protein signaling 13

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RGS13 mRNA

NCBI chr13:58,472,604...58,505,922
Ensembl chr13:58,472,604...58,505,922

G

regulator of G-protein signaling 16

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

regulator of G-protein signaling 4

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RGS4 mRNA

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

rhomboid 5 homolog 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of RHBDF1 mRNA

NCBI chr10:15,911,282...15,924,214
Ensembl chr10:15,911,308...15,924,214

G

ras homolog family member A

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of RHOA mRNA

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

Rho-related BTB domain containing 3

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA
Raloxifene Hydrochloride affects the expression of RHOBTB3 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:7,094,972...7,201,507
Ensembl chr 2:7,095,253...7,150,906

G

ras homolog family member F, filopodia associated

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RHOF mRNA

NCBI chr12:39,082,413...39,107,528
Ensembl chr12:39,091,979...39,107,528

G

RHO family interacting cell polarization regulator 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA

NCBI chr17:40,751,771...40,975,611
Ensembl chr17:40,751,771...40,975,337

G

Rho family GTPase 3

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536

G

ring finger protein 130

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of RNF130 mRNA

NCBI chr10:34,843,920...34,957,130
Ensembl chr10:34,843,915...34,960,408

G

ring finger protein 144B

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of RNF144B mRNA

NCBI chr17:17,637,564...17,786,685
Ensembl chr17:17,639,079...17,769,037

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

EXP

Raloxifene Hydrochloride results in decreased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

retinal outer segment membrane protein 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ROM1 mRNA

NCBI chr 1:215,253,155...215,255,163
Ensembl chr 1:215,253,159...215,255,163

G

ribosomal protein L6

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RPL6 mRNA

NCBI chr12:41,008,142...41,012,756
Ensembl chr12:41,008,142...41,025,733

G

regulation of nuclear pre-mRNA domain containing 1B

affects response to substance

ISO

RPRD1B protein affects the susceptibility to Raloxifene Hydrochloride

NCBI chr 3:167,102,909...167,149,184
Ensembl chr 3:167,102,859...167,206,374

G

ribosomal protein S6 kinase A2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RRAD mRNA

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

RAS related

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RRAS mRNA

NCBI chr 1:104,637,061...104,640,841
Ensembl chr 1:104,634,951...104,640,841

G

ribonucleotide reductase catalytic subunit M1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:166,235,900...166,260,944

G

RT1 class II, locus Bb

affects expression

EXP

Raloxifene Hydrochloride affects the expression of RT1-BB mRNA

NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118

G

RUNX family transcription factor 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RUNX2 mRNA

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

retinoid X receptor beta

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of RXRB mRNA

NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359

G

ryanodine receptor 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of RYR1 mRNA

NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305

G

S100 calcium binding protein A6

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of S100A6 protein]

NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762

G

scaffold attachment factor B

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SAFB mRNA

NCBI chr 9:1,504,657...1,525,545
Ensembl chr 9:1,504,456...1,525,781

G

spalt-like transcription factor 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SALL1 mRNA

NCBI chr19:34,179,316...34,196,278
Ensembl chr19:34,181,078...34,196,278

G

stearoyl-Coenzyme A desaturase 2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

sodium voltage-gated channel alpha subunit 4

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SCN4A mRNA

NCBI chr10:91,745,459...91,796,452
Ensembl chr10:91,746,715...91,796,324

G

sodium channel epithelial 1 subunit alpha

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SCNN1A mRNA

NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:159,809,170...159,832,405

G

syndecan 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of SDC1 mRNA

NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500

G

semaphorin 3A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SEMA3A mRNA

NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:22,245,322...22,535,774

G

semaphorin 3B

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA
Raloxifene Hydrochloride results in increased expression of SEMA3B mRNA

PMID:16202921 PMID:19059307

NCBI chr 8:117,150,307...117,161,570
Ensembl chr 8:117,150,589...117,157,658

G

semaphorin 3F

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SEMA3F mRNA

NCBI chr 8:117,236,269...117,265,206
Ensembl chr 8:117,236,269...117,265,206

G

semaphorin 4B

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SEMA4B mRNA

NCBI chr 1:143,545,727...143,587,037
Ensembl chr 1:143,537,690...143,587,037

G

serpin family A member 3N

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINA3 mRNA]

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family B member 2

increases expression
decreases expression

ISO

Raloxifene Hydrochloride results in increased expression of SERPINB2 mRNA
Raloxifene Hydrochloride results in decreased expression of SERPINB2 mRNA

PMID:16202921 PMID:16298037

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031

G

serpin family B member 6A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SERPINB6 mRNA

NCBI chr17:31,076,811...31,195,035
Ensembl chr17:31,158,622...31,196,545

G

serpin family B member 9

affects binding
multiple interactions

ISO

[Raloxifene Hydrochloride binds to ESR1 protein] which binds to SERPINB9 protein
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]

PMID:14617632 PMID:17237823

NCBI chr17:31,628,887...31,652,003
Ensembl chr17:31,629,392...31,651,974

G

serpin family E member 1

increases expression
multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride results in increased expression of SERPINE1 protein
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA
Raloxifene Hydrochloride results in decreased expression of SERPINE1 protein

PMID:15850603 PMID:16277677 PMID:19059307

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serpin family E member 2

affects expression

ISO
EXP

Raloxifene Hydrochloride affects the expression of SERPINE2 mRNA

PMID:14699072 PMID:16079270

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202

G

serpin family H member 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SERPINH1 mRNA

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

splicing factor proline and glutamine rich

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SFPQ mRNA

NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926

G

secreted frizzled-related protein 5

multiple interactions

ISO

SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]

NCBI chr 1:250,956,050...250,960,512
Ensembl chr 1:250,956,050...250,960,512

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SGK1 mRNA
Raloxifene Hydrochloride results in decreased expression of SGK1 mRNA
Raloxifene Hydrochloride affects the expression of SGK1 mRNA

PMID:14699072 PMID:19059307 PMID:26865669

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

serum/glucocorticoid regulated kinase family, member 3

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SGK3 mRNA

NCBI chr 5:14,128,628...14,255,099
Ensembl chr 5:14,126,257...14,198,331

G

SH2 domain containing adaptor protein B

affects expression

ISO

Raloxifene Hydrochloride affects the expression of SHB mRNA

NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:64,473,694...64,581,072

G

sex hormone binding globulin

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SHBG protein

PMID:16775175 PMID:16912660

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

shisa family member 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of SHISA2 mRNA

NCBI chr15:37,982,913...37,987,211
Ensembl chr15:37,982,169...37,988,535

G

siah E3 ubiquitin protein ligase 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873

G

S-phase kinase associated protein 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SKP2 mRNA

NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438

G

solute carrier family 17 member 7

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SLC17A7 mRNA

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 18 member A2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SLC18A2 mRNA

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 18 member A3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA

NCBI chr16:7,719,953...7,722,814

G

solute carrier family 19 member 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SLC19A1 mRNA

NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488

G

solute carrier family 1 member 2

multiple interactions
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Raloxifene Hydrochloride promotes the reaction [NFKB1 protein binds to SLC1A2 promoter]; Raloxifene Hydrochloride promotes the reaction [RELA protein binds to SLC1A2 promoter]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]
Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA; Raloxifene Hydrochloride results in increased expression of SLC1A2 protein

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 1 member 3

multiple interactions
increases expression

EXP

[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]
Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA; Raloxifene Hydrochloride results in increased expression of SLC1A3 protein

NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:59,482,709...59,557,808

G

solute carrier family 22 member 2

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

affects expression

ISO

Raloxifene Hydrochloride affects the expression of SLC22A5 mRNA

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 25 member 10

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of SLC25A10 mRNA

NCBI chr10:106,264,396...106,271,895
Ensembl chr10:106,264,344...106,273,498

G

solute carrier family 26 member 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SLC26A2 mRNA

NCBI chr18:56,918,662...56,937,032
Ensembl chr18:56,923,337...56,937,012

G

solute carrier family 2 member 3

affects expression

ISO

Raloxifene Hydrochloride affects the expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 2 member 4

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 38, member 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 6

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SLC39A6 mRNA

NCBI chr18:16,139,621...16,160,163
Ensembl chr18:16,135,008...16,160,163

G

solute carrier family 3 member 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 3

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of SLC6A3 protein

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

multiple interactions
affects expression

EXP

Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of SLC6A4 protein]
Raloxifene Hydrochloride affects the expression of SLC6A4 mRNA

PMID:16079270 PMID:17398000

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier family 7 member 11

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier family 7, member 4

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SLC7A4 mRNA

NCBI chr11:96,939,456...96,943,127
Ensembl chr11:96,939,444...96,943,802

G

solute carrier family 7 member 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412

G

solute carrier organic anion transporter family, member 4C1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SLCO4C1 mRNA

NCBI chr 9:104,624,802...104,676,462
Ensembl chr 9:104,624,802...104,676,462

G

slit guidance ligand 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SLIT1 mRNA

NCBI chr 1:250,358,917...250,507,476
Ensembl chr 1:250,358,919...250,507,476

G

sarcolipin

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of SLN mRNA

NCBI chr 8:63,117,577...63,144,290
Ensembl chr 8:63,139,722...63,143,971

G

SMAD family member 1

decreases phosphorylation

ISO

Raloxifene Hydrochloride results in decreased phosphorylation of SMAD1 protein

NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957

G

SMAD family member 2

decreases phosphorylation

ISO

Raloxifene Hydrochloride results in decreased phosphorylation of SMAD2 protein

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SMAD family member 7

affects expression

ISO

Raloxifene Hydrochloride affects the expression of SMAD7 mRNA

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849

G

SMAD specific E3 ubiquitin protein ligase 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SMURF2 mRNA

NCBI chr10:92,261,516...92,362,185
Ensembl chr10:92,261,525...92,362,552

G

synuclein alpha

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SNCA mRNA

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

stannin

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SNN mRNA

NCBI chr10:5,079,885...5,088,565
Ensembl chr 1:82,440,586...82,441,390
Ensembl chr10:82,440,586...82,441,390

G

superoxide dismutase 1

increases expression
affects response to substance
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of SOD1 mRNA
SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of BAP1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of CYLD mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of OTUD3 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP33 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP50 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of VCPIP1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD7B mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of UBXN1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of YOD1 mRNA

PMID:12154049 PMID:33269387

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

SON DNA and RNA binding protein

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SON mRNA

NCBI chr11:44,336,818...44,409,127
Ensembl chr11:44,377,976...44,409,127

G

Sp4 transcription factor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SP4 protein

NCBI chr 6:145,330,416...145,395,750
Ensembl chr 6:145,330,416...145,395,146

G

secreted protein acidic and cysteine rich

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SPARC mRNA

NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268

G

spermatogenesis associated 13

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SPATA13 mRNA

NCBI chr15:38,954,585...39,083,752
Ensembl chr15:38,810,386...39,083,755

G

serine peptidase inhibitor, Kazal type 1

multiple interactions

ISO

[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of SPINK1 mRNA

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

sialophorin

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SPN mRNA

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SPOCK3 mRNA

NCBI chr16:31,149,698...31,582,280
Ensembl chr16:31,149,702...31,582,398

G

secreted phosphoprotein 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sequestosome 1

increases expression
multiple interactions

EXP
ISO

Raloxifene Hydrochloride results in increased expression of SQSTM1 mRNA
Raloxifene Hydrochloride results in increased expression of SQSTM1 protein
[Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased expression of SQSTM1 protein

PMID:15576828 PMID:33203845

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

SRSF protein kinase 2

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SRPK2 mRNA

NCBI chr 4:12,356,983...12,548,345
Ensembl chr 4:12,357,053...12,548,342

G

serine and arginine rich splicing factor 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SRSF1 mRNA

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:73,336,422...73,342,548

G

serine and arginine rich splicing factor 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SRSF3 mRNA

NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,093,565...7,103,516

G

serine and arginine rich splicing factor 7

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of SRSF7 mRNA

NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212

G

single-stranded DNA binding protein 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of SSBP2 mRNA

NCBI chr 2:24,385,494...24,673,768
Ensembl chr 2:24,385,687...24,673,768

G

slingshot protein phosphatase 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SSH1 mRNA

NCBI chr12:48,281,756...48,343,812
Ensembl chr12:48,281,756...48,343,812

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA

NCBI chr 7:100,734,300...100,802,443
Ensembl chr 7:100,734,300...100,745,242

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ST3GAL2 mRNA

NCBI chr19:55,798,112...55,849,226
Ensembl chr19:55,799,471...55,849,225

G

signal transducer and activator of transcription 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

ISO
EXP

[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased phosphorylation of STAT3 protein]]; Raloxifene Hydrochloride inhibits the reaction [[IL6R protein co-treated with IL6 protein] results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL4 protein results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Raloxifene Hydrochloride results in increased cleavage of CASP3 protein]
Raloxifene Hydrochloride results in decreased phosphorylation of STAT3 protein
Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to IL6 protein] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:17336289 PMID:24456369 PMID:28430601 PMID:28711499 PMID:32828944 More...

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

starch binding domain 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of STBD1 mRNA

NCBI chr14:15,754,769...15,758,174
Ensembl chr14:15,754,644...15,761,659

G

stanniocalcin 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

serine/threonine kinase 24

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of STK24 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of STK24 mRNA

PMID:14699072 PMID:19059307

NCBI chr15:104,770,556...104,866,524
Ensembl chr15:104,773,569...104,865,975

G

serine/threonine kinase 26

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of STK26 mRNA

NCBI chr X:135,195,176...135,259,994
Ensembl chr X:135,195,204...135,259,993

G

stathmin 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

syntaxin 16

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of STX16 mRNA

NCBI chr 3:183,271,417...183,300,746
Ensembl chr 3:183,272,031...183,300,745

G

syntaxin 1A

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of STX1A mRNA

NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471

G

sulfotransferase family 5A, member 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of SULT5A1 mRNA

NCBI chr19:68,097,808...68,115,426
Ensembl chr19:68,097,808...68,112,656

G

syntabulin

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SYBU mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYBU mRNA

NCBI chr 7:77,731,662...77,833,413
Ensembl chr 7:77,731,605...77,833,686

G

synaptojanin 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA

NCBI chr 1:48,923,742...49,027,153
Ensembl chr 1:48,923,737...49,038,650

G

synaptopodin

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNPO mRNA

NCBI chr18:56,326,369...56,347,359
Ensembl chr18:56,319,571...56,353,306

G

transforming, acidic coiled-coil containing protein 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of TACC1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC1 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:73,515,016...73,598,395
Ensembl chr16:73,514,889...73,598,394

G

transforming, acidic coiled-coil containing protein 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC2 mRNA

NCBI chr 1:194,546,428...194,758,152
Ensembl chr 1:194,569,650...194,758,152

G

TATA-box binding protein associated factor 9

increases expression
decreases expression

ISO

Raloxifene Hydrochloride results in increased expression of TAF9 mRNA
Raloxifene Hydrochloride results in decreased expression of TAF9 mRNA

PMID:12154049 PMID:16514628

NCBI chr 2:33,528,388...33,532,395
Ensembl chr 2:33,531,368...33,536,078

G

TAO kinase 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TAOK3 mRNA

NCBI chr12:44,973,180...45,134,439
Ensembl chr12:44,973,180...45,134,439

G

threonyl-tRNA synthetase 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TARS1 mRNA

NCBI chr 2:62,095,978...62,114,802
Ensembl chr 2:62,087,763...62,114,802

G

T-box transcription factor 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TBX2 mRNA

NCBI chr10:71,177,082...71,186,275
Ensembl chr10:71,177,082...71,186,275

G

thromboxane A2 receptor

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA

NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905

G

T-box transcription factor T

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TBXT mRNA

NCBI chr 1:54,845,674...54,859,340
Ensembl chr 1:54,845,674...54,853,583

G

transcriptional and immune response regulator

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TCIM mRNA

NCBI chr16:74,298,344...74,299,637
Ensembl chr16:74,298,344...74,299,636

G

t-complex 1

affects expression

EXP

Raloxifene Hydrochloride affects the expression of TCP1 mRNA

NCBI chr 1:50,376,848...50,384,527
Ensembl chr 1:50,376,848...50,384,527

G

telomerase reverse transcriptase

multiple interactions
increases expression
increases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of TERT mRNA; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]; Raloxifene Hydrochloride results in increased expression of and results in increased activity of TERT protein; SN50 peptide inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride promotes the reaction [TERT protein binds to RELA protein]; Raloxifene Hydrochloride results in increased phosphorylation of and results in increased activity of TERT protein
Raloxifene Hydrochloride results in increased expression of TERT mRNA
Raloxifene Hydrochloride results in increased phosphorylation of TERT protein

PMID:15590986 PMID:16798746 PMID:27017931

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

transcription factor A, mitochondrial

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of TFAM mRNA
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of TFAM mRNA]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transcription factor AP-2 alpha

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of TFAP2A mRNA
[Streptozocin co-treated with Raloxifene Hydrochloride] results in increased expression of TFAP2A protein

PMID:23471663 PMID:26865669

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219

G

transcription factor AP-2 gamma

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TFAP2C mRNA

NCBI chr 3:181,733,524...181,742,412
Ensembl chr 3:181,733,419...181,741,404

G

trefoil factor 1

affects binding
multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride binds to ESR1 protein] which binds to TFF1 protein
[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of TFF1 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TFF1 mRNA; [Raloxifene Hydrochloride co-treated with trichostatin A] results in decreased expression of TFF1 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TFF1 protein]; trichostatin A inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TFF1 mRNA]
Raloxifene Hydrochloride results in decreased expression of TFF1 mRNA; Raloxifene Hydrochloride results in decreased expression of TFF1 protein

PMID:14617632 PMID:16202921 PMID:16514628 PMID:21185374 PMID:22476901 More...

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

trefoil factor 3

affects expression
decreases expression

ISO

Raloxifene Hydrochloride affects the expression of TFF3 mRNA
Raloxifene Hydrochloride results in decreased expression of TFF3 mRNA

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333

G

tissue factor pathway inhibitor

multiple interactions
increases expression

ISO

[fulvestrant co-treated with Raloxifene Hydrochloride] results in increased secretion of TFPI protein; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein]; Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein
Raloxifene Hydrochloride results in increased expression of TFPI mRNA

PMID:17029634 PMID:26865669

NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742

G

transferrin receptor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transforming growth factor alpha

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TGFA mRNA; Raloxifene Hydrochloride inhibits the reaction [TGFA protein results in increased phosphorylation of AKT1 protein]

PMID:19059307 PMID:35007301

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

transforming growth factor, beta 1

multiple interactions
decreases expression

ISO

Raloxifene Hydrochloride inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]
Raloxifene Hydrochloride results in decreased expression of TGFB1 mRNA; Raloxifene Hydrochloride results in decreased expression of TGFB1 protein modified form
Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA]

PMID:15920148 PMID:31583774 PMID:32947957

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of TGFB2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TGFB2 mRNA

PMID:14699072 PMID:19059307 PMID:21185374

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TGFB3 mRNA]
Raloxifene Hydrochloride affects the expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transforming growth factor, beta induced

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of TGFBI mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFBI mRNA

PMID:14699072 PMID:19059307

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471

G

transforming growth factor, beta receptor 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TGFBR2 mRNA

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469

G

transglutaminase 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TGM2 mRNA

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

thrombospondin 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thrombospondin 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of THBS2 mRNA

NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:64,343,523...64,372,918

G

Thy-1 cell surface antigen

affects expression
increases expression

ISO
EXP

Raloxifene Hydrochloride affects the expression of THY1 mRNA
Raloxifene Hydrochloride results in increased expression of THY1 mRNA

PMID:14699072 PMID:15576828

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions
affects expression

ISO
EXP

Raloxifene Hydrochloride results in increased expression of TIMP1 mRNA; Raloxifene Hydrochloride results in increased expression of TIMP1 protein
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of TIMP1 protein
Raloxifene Hydrochloride affects the expression of TIMP1 mRNA

PMID:16079270 PMID:16202921 PMID:21935668 PMID:31332895

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in increased secretion of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

TIMP metallopeptidase inhibitor 3

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TIMP3 mRNA; Raloxifene Hydrochloride results in increased expression of TIMP3 protein

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

TCDD-inducible poly(ADP-ribose) polymerase

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406

G

TLE family member 1, transcriptional corepressor

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TLE1 mRNA

NCBI chr 5:90,898,182...90,982,118
Ensembl chr 5:90,898,182...90,980,928

G

toll-like receptor 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

transmembrane protein 158

multiple interactions
affects expression

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TMEM158 mRNA
Raloxifene Hydrochloride affects the expression of TMEM158 mRNA

PMID:14699072 PMID:19059307

NCBI chr 8:131,791,137...131,792,135
Ensembl chr 8:131,787,277...131,796,882

G

tropomodulin 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of TMOD1 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 5:65,112,062...65,189,563
Ensembl chr 5:65,134,132...65,189,561

G

thymopoietin

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TMPO mRNA

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

transmembrane serine protease 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA

NCBI chr20:9,253,497...9,275,167
Ensembl chr20:9,255,467...9,275,720

G

transmembrane serine protease 6

affects response to substance

ISO

TMPRSS6 affects the susceptibility to Raloxifene Hydrochloride

NCBI chr 7:111,871,504...111,902,127
Ensembl chr 7:111,871,031...111,902,116

G

thiol methyltransferase 1A

multiple interactions
affects expression

ISO

ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TMT1A mRNA]
Raloxifene Hydrochloride affects the expression of TMT1A mRNA

NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:133,330,447...133,338,959

G

tenascin C

affects expression
decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of TNC mRNA
Raloxifene Hydrochloride results in decreased expression of TNC mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNC mRNA

PMID:14699072 PMID:19059307 PMID:32947957

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

decreases expression
multiple interactions

ISO
EXP

Raloxifene Hydrochloride results in decreased expression of TNF protein
Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TNF mRNA]
Raloxifene Hydrochloride results in decreased expression of TNF mRNA
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in increased secretion of TNF protein]

PMID:15579764 PMID:24782323 PMID:25305410 PMID:31470850 PMID:31583774

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TNFAIP3 mRNA

PMID:19429434 PMID:33269387

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 11A

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TNFRSF11A mRNA

NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257

G

TNF receptor superfamily member 11B

multiple interactions
increases expression
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF11B mRNA; Raloxifene Hydrochloride results in increased expression of and results in increased secretion of TNFRSF11B protein
Raloxifene Hydrochloride results in increased expression of TNFRSF11B mRNA; Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein
Raloxifene Hydrochloride results in decreased expression of TNFRSF11B mRNA

PMID:16005483 PMID:16787719 PMID:17420779 PMID:19059307 PMID:19429434 More...

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 21

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNA

NCBI chr 9:25,376,400...25,451,323
Ensembl chr 9:25,376,400...25,451,323

G

TNF receptor superfamily member 25

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TNFRSF25 mRNA

NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052

G

TNF superfamily member 11

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TNFSF11 mRNA; Raloxifene Hydrochloride results in decreased expression of TNFSF11 protein

PMID:16005483 PMID:19401787 PMID:27576059

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TNF superfamily member 15

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TNFSF15 mRNA

NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:82,150,376...82,171,882

G

TRAF2 and NCK interacting kinase

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNIK mRNA

NCBI chr 2:113,112,937...113,511,341
Ensembl chr 2:113,112,938...113,511,339

G

troponin I3, cardiac type

affects expression

EXP

Raloxifene Hydrochloride affects the expression of TNNI3 mRNA

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

transportin 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TNPO1 mRNA

NCBI chr 2:31,941,731...32,034,366
Ensembl chr 2:31,941,731...32,034,326

G

tensin 3

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TNS3 mRNA

PMID:19059307 PMID:21185374

NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712

G

transducer of ErbB-2.1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TOB1 mRNA

NCBI chr10:79,659,993...79,662,031
Ensembl chr10:79,656,433...79,666,601

G

target of myb1 membrane trafficking protein

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TOM1 mRNA

NCBI chr19:13,411,227...13,446,129
Ensembl chr19:13,411,157...13,446,110

G

DNA topoisomerase I

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TOP1 mRNA

NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327

G

DNA topoisomerase II alpha

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

DNA topoisomerase II beta

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TOP2B mRNA

NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464

G

tumor protein p53

multiple interactions
increases expression

ISO

[Raloxifene Hydrochloride co-treated with Resveratrol] results in increased expression of TP53 mRNA
Raloxifene Hydrochloride results in increased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible protein 11

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TP53I11 mRNA

NCBI chr 3:99,600,213...99,615,462
Ensembl chr 3:99,600,159...99,615,432

G

tumor protein p53 inducible nuclear protein 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TP53INP1 mRNA

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484

G

tumor protein p73

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TP73 mRNA

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

tropomyosin 1

affects expression

ISO
EXP

Raloxifene Hydrochloride affects the expression of TPM1 mRNA

PMID:14699072 PMID:16079270

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468

G

tyrosylprotein sulfotransferase 1

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TPST1 mRNA

NCBI chr12:32,180,688...32,247,478
Ensembl chr12:32,180,936...32,241,821

G

Traf3 interacting protein 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA

NCBI chr20:44,565,992...44,609,240
Ensembl chr20:44,517,242...44,609,618

G

TNF receptor-associated factor 5

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRAF5 mRNA

NCBI chr13:106,100,921...106,149,724
Ensembl chr13:106,103,291...106,149,707

G

trafficking kinesin protein 2

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TRAK2 mRNA

NCBI chr 9:67,842,680...67,909,786
Ensembl chr 9:67,842,683...67,908,158

G

tribbles pseudokinase 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

tribbles pseudokinase 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TRIB2 mRNA

NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:44,274,762...44,299,094

G

tripartite motif-containing 25

multiple interactions

ISO

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]

NCBI chr10:74,310,024...74,328,473
Ensembl chr10:74,310,022...74,331,716

G

tripartite motif-containing 36

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA

NCBI chr18:41,047,657...41,099,497
Ensembl chr18:41,047,657...41,104,704

G

tubulin, alpha 1B

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of TUBA1B mRNA

NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:131,968,770...131,996,035

G

twinfilin actin-binding protein 2

affects expression

ISO

Raloxifene Hydrochloride affects the expression of TWF2 mRNA

NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:115,723,970...115,737,025

G

thioredoxin interacting protein

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

ubiquitin B

affects expression

EXP

Raloxifene Hydrochloride affects the expression of UBB mRNA

NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,727,701...47,750,335

G

ubiquitin protein ligase E3C

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of UBE3C mRNA

NCBI chr 4:6,323,831...6,425,085
Ensembl chr 4:6,323,831...6,424,845

G

UBX domain protein 1

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of UBXN1 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of UBXN1 mRNA

NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:215,174,216...215,198,343

G

UDP glucuronosyltransferase family 1 member A1

affects glucuronidation
multiple interactions
increases glucuronidation

ISO

UGT1A1 mRNA alternative form affects the glucuronidation of Raloxifene Hydrochloride
[[MIR491 results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Raloxifene Hydrochloride] which results in decreased abundance of Raloxifene Hydrochloride metabolite; [MIR491 results in decreased activity of UGT1A1 protein] which results in decreased abundance of Raloxifene Hydrochloride metabolite; [MIR491 results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Raloxifene Hydrochloride
UGT1A1 protein results in increased glucuronidation of Raloxifene Hydrochloride

PMID:22661630 PMID:23682072 PMID:24399855

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

ISO

UGT1A3 protein results in increased glucuronidation of Raloxifene Hydrochloride

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of Raloxifene Hydrochloride

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

uracil-DNA glycosylase

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of UNG mRNA

NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257

G

UPF1, RNA helicase and ATPase

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of UPF1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:19,110,531...19,131,327
Ensembl chr16:19,110,538...19,131,327

G

ubiquitin specific peptidase 13

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP13 mRNA

NCBI chr 2:117,502,811...117,617,049
Ensembl chr 2:117,505,122...117,630,161

G

ubiquitin specific peptidase 19

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP19 mRNA

NCBI chr 8:118,069,227...118,080,283
Ensembl chr 8:118,069,240...118,080,300

G

ubiquitin specific peptidase 20

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP20 mRNA

NCBI chr 3:34,670,613...34,704,156
Ensembl chr 3:34,670,685...34,704,156

G

ubiquitin specific peptidase 25

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP25 mRNA

NCBI chr11:29,088,283...29,198,323
Ensembl chr11:29,087,736...29,198,323

G

ubiquitin specific peptidase 32

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP32 mRNA

NCBI chr10:70,353,310...70,538,008
Ensembl chr10:70,353,310...70,538,324

G

ubiquitin specific peptidase 33

decreases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in decreased expression of USP33 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP33 mRNA

NCBI chr 2:243,938,958...243,988,424
Ensembl chr 2:243,943,175...243,988,424

G

ubiquitin specific peptidase 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP5 mRNA

NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:159,305,938...159,320,956

G

ubiquitin specific peptidase 50

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of USP50 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP50 mRNA

NCBI chr 3:134,465,469...134,488,859
Ensembl chr 3:134,464,499...134,488,816

G

ubiquitin specific peptidase 7

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP7 mRNA

NCBI chr10:7,335,508...7,432,018
Ensembl chr10:7,367,604...7,432,013

G

ubiquitin specific peptidase 8

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP8 mRNA

NCBI chr 3:134,413,832...134,463,040
Ensembl chr 3:134,415,391...134,463,032

G

ubiquitin specific peptidase 9, X-linked

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of USP9X mRNA

NCBI chr X:12,261,633...12,399,780
Ensembl chr X:12,261,633...12,369,491

G

vascular cell adhesion molecule 1

multiple interactions

ISO

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

valosin containing protein interacting protein 1

multiple interactions
decreases expression

ISO

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of VCPIP1 mRNA
Raloxifene Hydrochloride results in decreased expression of VCPIP1 mRNA

NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778

G

vitamin D receptor

affects response to substance
multiple interactions

ISO

VDR gene polymorphism affects the susceptibility to Raloxifene Hydrochloride
VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Raloxifene Hydrochloride]

PMID:15739035 PMID:16604479

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

vascular endothelial growth factor A

multiple interactions
increases expression

ISO
EXP

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of VEGFA protein]
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of VEGFA protein
Raloxifene Hydrochloride results in increased expression of VEGFA mRNA

PMID:16497877 PMID:19148513 PMID:31332895

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

von Willebrand factor

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of VWF protein

NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757

G

WASP actin nucleation promoting factor

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of WAS mRNA

NCBI chr X:17,077,057...17,085,802
Ensembl chr X:17,073,314...17,085,802

G

WD repeat domain 1

affects expression

ISO

Raloxifene Hydrochloride affects the expression of WDR1 mRNA

NCBI chr14:76,470,238...76,504,086
Ensembl chr14:76,470,176...76,504,080

G

WAP four-disulfide core domain 1

increases expression

EXP

Raloxifene Hydrochloride results in increased expression of WFDC1 mRNA

NCBI chr19:64,628,689...64,647,739
Ensembl chr19:64,607,794...64,648,028

G

Wnt family member 11

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of WNT11 mRNA

NCBI chr 1:162,545,660...162,565,456
Ensembl chr 1:162,545,680...162,564,660

G

Wnt family member 5A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of WNT5A mRNA

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860

G

WW and C2 domain containing 1

affects expression
decreases expression

ISO

Raloxifene Hydrochloride affects the expression of WWC1 mRNA
Raloxifene Hydrochloride results in decreased expression of WWC1 mRNA

PMID:14699072 PMID:26865669

NCBI chr10:20,804,173...20,958,437
Ensembl chr10:20,799,237...20,958,437

G

xanthine dehydrogenase

increases activity
multiple interactions

ISO

Raloxifene Hydrochloride results in increased activity of XDH protein
XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

exportin 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of XPO1 mRNA

NCBI chr14:101,434,450...101,476,705
Ensembl chr14:101,434,517...101,476,714

G

X-ray repair cross complementing 5

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of XRCC5 mRNA

NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293

G

Y box binding protein 3

affects expression

EXP

Raloxifene Hydrochloride affects the expression of YBX3 mRNA

NCBI chr 4:166,861,180...166,884,532
Ensembl chr 4:166,861,181...166,884,691

G

YOD1 deubiquitinase

increases expression
multiple interactions

ISO

Raloxifene Hydrochloride results in increased expression of YOD1 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of YOD1 mRNA

NCBI chr13:44,727,319...44,733,933

G

zinc finger CCHC-type containing 24

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of ZCCHC24 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZCCHC24 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:1,281,350...1,333,278
Ensembl chr16:1,281,350...1,333,350

G

zinc finger E-box binding homeobox 1

decreases expression

ISO

Raloxifene Hydrochloride results in decreased expression of ZEB1 mRNA

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger protein 36

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of ZFP36 mRNA]
Raloxifene Hydrochloride affects the expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 395

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZNF395 mRNA

NCBI chr15:43,757,350...43,797,513
Ensembl chr15:43,757,473...43,797,512

G

zinc finger protein X-linked

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ZFX mRNA

NCBI chr X:62,798,483...62,847,068
Ensembl chr X:62,798,483...62,875,309

G

zinc finger, MIZ-type containing 1

affects expression
multiple interactions

ISO

Raloxifene Hydrochloride affects the expression of ZMIZ1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:1,033,983...1,239,425
Ensembl chr16:1,034,020...1,239,406

G

zinc finger MYM-type containing 2

increases expression

ISO

Raloxifene Hydrochloride results in increased expression of ZMYM2 mRNA

NCBI chr15:35,151,356...35,224,528
Ensembl chr15:35,127,994...35,224,941

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

multiple interactions
decreases expression

EXP
ISO

[bexarotene co-treated with Tamoxifen] results in decreased expression of A1BG mRNA
Tamoxifen results in decreased expression of A1BG mRNA

PMID:17630414 PMID:25123088

NCBI chr 7:94,383,333...94,387,922
Ensembl chr 7:94,383,333...94,387,496

G

acetoacetyl-CoA synthetase

affects expression

ISO

Tamoxifen affects the expression of AACS mRNA

NCBI chr12:36,774,471...36,817,835
Ensembl chr12:36,774,471...36,822,543

G

apoptosis antagonizing transcription factor

affects expression

ISO

Tamoxifen affects the expression of AATF mRNA

NCBI chr10:69,796,502...69,889,671
Ensembl chr10:69,794,007...69,889,634

G

ATP binding cassette subfamily A member 1

increases expression

ISO

Tamoxifen results in increased expression of ABCA1 protein

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily A member 4

decreases expression

ISO

Tamoxifen results in decreased expression of ABCA4 mRNA

NCBI chr 2:212,849,470...212,986,730
Ensembl chr 2:212,755,803...212,986,729

G

ATP binding cassette subfamily B member 11

decreases activity
increases expression
decreases expression

ISO
EXP

Tamoxifen results in decreased activity of ABCB11 protein
Tamoxifen results in increased expression of ABCB11 mRNA
Tamoxifen results in decreased expression of ABCB11 mRNA

PMID:12135489 PMID:12739759 PMID:19224547 PMID:27765674

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases expression
decreases activity
affects expression
increases expression

ISO
EXP

[Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Tamoxifen; [Tamoxifen results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Tamoxifen results in increased expression of ABCB1 protein]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ABCB1 protein]
Tamoxifen results in decreased expression of ABCB1A mRNA
Tamoxifen results in decreased activity of ABCB1A protein
Tamoxifen affects the expression of ABCB1A mRNA
Tamoxifen affects the reaction [ABCB1 protein results in increased secretion of Doxorubicin]; Tamoxifen inhibits the reaction [Doxorubicin affects the activity of ABCB1 protein]

PMID:12202523 PMID:15290871 PMID:15937726 PMID:16925584 PMID:17555576 More...

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

decreases activity

EXP

Tamoxifen results in decreased activity of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily B member 4

decreases activity

EXP
ISO

Tamoxifen results in decreased activity of ABCB4 protein

PMID:12202523 PMID:28437613

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA
Tamoxifen affects the expression of ABCC1 mRNA

PMID:17555576 PMID:19059307

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

affects response to substance
increases expression

ISO
EXP

ABCC2 gene affects the susceptibility to Tamoxifen
Tamoxifen results in increased expression of ABCC2 mRNA

PMID:20124171 PMID:27765674

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of ABCC3 mRNA
Tamoxifen results in increased expression of ABCC3 mRNA

PMID:17555576 PMID:19224547

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

decreases expression

EXP

Tamoxifen results in decreased expression of ABCC4 mRNA

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily D member 1

decreases expression

ISO

Tamoxifen results in decreased expression of ABCD1 mRNA

NCBI chr X:156,579,669...156,601,448
Ensembl chr X:156,579,785...156,601,446

G

ATP binding cassette subfamily D member 3

decreases expression

ISO

Tamoxifen results in decreased expression of ABCD3 mRNA

NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504

G

ATP binding cassette subfamily F member 2

affects expression

ISO

Tamoxifen affects the expression of ABCF2 mRNA

NCBI chr 4:11,485,865...11,500,067
Ensembl chr 4:11,487,395...11,500,053

G

ATP binding cassette subfamily G member 1

increases expression

ISO

Tamoxifen results in increased expression of ABCG1 protein

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ATP binding cassette subfamily G member 2

multiple interactions
increases expression

ISO

Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ABCG2]
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of ABCG2 mRNA
Tamoxifen metabolite results in increased expression of ABCG2 mRNA

PMID:15695404 PMID:29285606 PMID:29974145

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ATP binding cassette subfamily G member 5

increases expression

ISO

Tamoxifen results in increased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

abhydrolase domain containing 12, lysophospholipase

affects expression

ISO

Tamoxifen affects the expression of ABHD12 mRNA

NCBI chr 3:160,119,724...160,179,959
Ensembl chr 3:160,119,724...160,179,969

G

abhydrolase domain containing 14b

affects expression

ISO

Tamoxifen affects the expression of ABHD14B mRNA

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833

G

abhydrolase domain containing 15

decreases expression

ISO

Tamoxifen results in decreased expression of ABHD15 mRNA

NCBI chr10:62,861,335...62,866,726
Ensembl chr10:62,861,317...62,868,540

G

abhydrolase domain containing 2, acylglycerol lipase

decreases expression

ISO

Tamoxifen results in decreased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

abhydrolase domain containing 4, N-acyl phospholipase B

affects expression

ISO

Tamoxifen affects the expression of ABHD4 mRNA

NCBI chr15:31,674,090...31,686,051
Ensembl chr15:31,674,143...31,687,007

G

abhydrolase domain containing 6, acylglycerol lipase

affects expression

ISO

Tamoxifen affects the expression of ABHD6 mRNA

NCBI chr15:19,289,967...19,337,500
Ensembl chr15:19,289,969...19,337,193

G

ABI family, member 3

affects expression

ISO

Tamoxifen affects the expression of ABI3 mRNA

NCBI chr10:81,266,571...81,277,561
Ensembl chr10:81,266,571...81,277,561

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

affects expression
decreases response to substance

ISO

Tamoxifen affects the expression of ABL1 mRNA
ABL1 protein results in decreased susceptibility to Tamoxifen

PMID:17555576 PMID:20234815

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

actin-binding LIM protein 1

decreases expression

ISO

Tamoxifen results in decreased expression of ABLIM1 mRNA

NCBI chr 1:266,088,868...266,377,169
Ensembl chr 1:266,088,870...266,377,098

G

actin binding LIM protein family, member 3

affects expression

ISO

Tamoxifen affects the expression of ABLIM3 mRNA

NCBI chr18:57,527,917...57,646,936
Ensembl chr18:57,527,917...57,646,710

G

abraxas 2, BRISC complex subunit

increases expression

ISO

Tamoxifen results in increased expression of ABRAXAS2 mRNA

NCBI chr 1:197,077,177...197,102,753
Ensembl chr 1:197,077,158...197,102,757

G

ankyrin repeat and BTB domain containing 1

affects expression

ISO

Tamoxifen affects the expression of ABTB1 mRNA

NCBI chr 4:122,856,558...122,862,895
Ensembl chr 4:122,856,564...122,862,789

G

acetyl-CoA acyltransferase 1A

multiple interactions
increases expression

EXP

[Tamoxifen co-treated with bexarotene] results in increased expression of ACAA1 mRNA
Tamoxifen results in increased expression of ACAA1 mRNA

NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241

G

acetyl-CoA carboxylase beta

decreases expression

ISO

Tamoxifen results in decreased expression of ACACB mRNA

NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214

G

acyl-CoA dehydrogenase medium chain

affects expression

ISO

Tamoxifen affects the expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acyl-CoA dehydrogenase, short/branched chain

affects expression

ISO

Tamoxifen affects the expression of ACADSB mRNA

NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

increases expression

ISO

Tamoxifen results in increased expression of ACAP2 mRNA

NCBI chr11:83,043,442...83,159,105
Ensembl chr11:83,043,511...83,159,107

G

acetyl-CoA acetyltransferase 1

decreases expression
increases expression
multiple interactions

EXP

Tamoxifen results in decreased expression of ACAT1 mRNA
Tamoxifen results in increased expression of ACAT1 mRNA
[Tamoxifen co-treated with bexarotene] results in increased expression of ACAT1 mRNA

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042

G

acetyl-CoA acetyltransferase 2

affects expression

ISO

Tamoxifen affects the expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

atypical chemokine receptor 3

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ACKR3 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214

G

ATP citrate lyase

affects expression

ISO

Tamoxifen affects the expression of ACLY mRNA

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

acyl-CoA thioesterase 1

increases expression
multiple interactions

EXP

Tamoxifen results in increased expression of ACOT1 mRNA
[Tamoxifen co-treated with Bexarotene] results in increased expression of ACOT1 mRNA

NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:109,367,268...109,380,749

G

acyl-CoA thioesterase 3

affects expression
decreases expression

ISO

Tamoxifen affects the expression of ACOT3 mRNA
Tamoxifen results in decreased expression of ACOT3 mRNA

PMID:17555576 PMID:20937368 PMID:25123088

NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:109,413,534...109,421,427
Ensembl chr 6:109,413,534...109,421,427

G

acyl-CoA oxidase 2

decreases expression

EXP

Tamoxifen results in decreased expression of ACOX2 mRNA

NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392

G

acid phosphatase 1

affects expression

ISO

Tamoxifen affects the expression of ACP1 mRNA

NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:53,233,948...53,251,959

G

acrosin binding protein

affects expression

ISO

Tamoxifen affects the expression of ACRBP mRNA

NCBI chr 4:159,537,395...159,550,454
Ensembl chr 4:159,537,391...159,550,454

G

acrosomal vesicle protein 1

affects expression

ISO

Tamoxifen affects the expression of ACRV1 mRNA

NCBI chr 8:44,593,246...44,598,823
Ensembl chr 8:44,592,344...44,599,019

G

acyl-CoA synthetase bubblegum family member 1

affects expression

ISO

Tamoxifen affects the expression of ACSBG1 mRNA

NCBI chr 8:63,887,433...63,943,486
Ensembl chr 8:63,887,435...63,984,178

G

acyl-CoA synthetase long-chain family member 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA
Tamoxifen affects the expression of ACSL1 mRNA

PMID:14699072 PMID:17555576 PMID:19059307

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

acyl-CoA synthetase medium-chain family member 2

affects expression

ISO

Tamoxifen affects the expression of ACSM2 mRNA

NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453

G

acyl-CoA synthetase medium-chain family member 3

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of SAH mRNA

NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437

G

acyl-CoA synthetase short-chain family member 2

affects expression

ISO

Tamoxifen affects the expression of ACSS2 mRNA

NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830

G

actin alpha 2, smooth muscle

affects expression

ISO

Tamoxifen affects the expression of ACTA2 mRNA

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

actin, alpha, cardiac muscle 1

affects expression

ISO

Tamoxifen affects the expression of ACTC1 mRNA

NCBI chr 3:121,266,291...121,271,827
Ensembl chr 3:121,266,291...121,271,827

G

actin, gamma 1

affects expression

ISO

Tamoxifen affects the expression of ACTG1 mRNA

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951

G

actin related protein 1B

decreases expression

ISO

Tamoxifen results in decreased expression of ACTR1B mRNA

NCBI chr 9:46,424,677...46,434,341
Ensembl chr 9:46,424,678...46,434,341

G

actin related protein 2

affects expression

ISO

Tamoxifen affects the expression of ACTR2 mRNA

NCBI chr14:98,500,119...98,535,092
Ensembl chr14:98,500,138...98,541,998

G

actin related protein 3

affects expression

ISO

Tamoxifen affects the expression of ACTR3 mRNA

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

actin related protein 8

affects expression

ISO

Tamoxifen affects the expression of ACTR8 mRNA

NCBI chr16:5,170,649...5,192,883
Ensembl chr16:5,167,237...5,186,180

G

actin-related protein T2

decreases expression

ISO

Tamoxifen results in decreased expression of ACTRT2 mRNA

NCBI chr 5:170,518,470...170,519,870
Ensembl chr 5:170,518,165...170,521,164

G

activin A receptor type 2B

decreases expression

ISO

Tamoxifen results in decreased expression of ACVR2B mRNA

NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:128,016,526...128,048,171

G

adenosine deaminase

affects expression

ISO

Tamoxifen affects the expression of ADA mRNA

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293

G

ADAM metallopeptidase domain 17

affects expression

ISO

Tamoxifen affects the expression of ADAM17 mRNA

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

ADAM metallopeptidase domain 18

affects expression

ISO

Tamoxifen affects the expression of ADAM18 mRNA

NCBI chr16:74,054,974...74,127,861
Ensembl chr16:74,055,008...74,127,864

G

ADAM metallopeptidase domain 19

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA

NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455

G

ADAM metallopeptidase domain 22

decreases expression

ISO

Tamoxifen results in decreased expression of ADAM22 mRNA

NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:26,671,112...26,925,843

G

ADAM metallopeptidase domain 32

increases expression

ISO

Tamoxifen results in increased expression of ADAM32 mRNA

NCBI chr16:73,805,023...73,914,787
Ensembl chr16:73,805,052...73,914,785

G

ADAM metallopeptidase domain 9

affects expression

ISO

Tamoxifen affects the expression of ADAM9 mRNA

PMID:14699072 PMID:17555576

NCBI chr16:73,725,186...73,804,284
Ensembl chr16:73,725,114...73,804,646

G

ADAM metallopeptidase with thrombospondin type 1 motif, 14

increases expression

ISO

Tamoxifen results in increased expression of ADAMTS14 mRNA

NCBI chr20:29,685,876...29,762,685
Ensembl chr20:29,685,876...29,762,682

G

ADAM metallopeptidase with thrombospondin type 1 motif, 7

increases expression

ISO

Tamoxifen results in increased expression of ADAMTS7 mRNA

NCBI chr 8:99,584,529...99,624,132
Ensembl chr 8:99,584,529...99,624,132

G

ADAMTS-like 4

affects expression

ISO

Tamoxifen affects the expression of ADAMTSL4 mRNA

NCBI chr 2:185,924,582...185,936,039
Ensembl chr 2:185,924,594...185,935,796

G

adenosine deaminase, RNA-specific

affects expression

ISO

Tamoxifen affects the expression of ADAR mRNA

NCBI chr 2:177,436,076...177,475,969
Ensembl chr 2:177,436,094...177,475,971

G

adenosine deaminase, tRNA-specific 2

affects expression

ISO

Tamoxifen affects the expression of ADAT2 mRNA

NCBI chr 1:9,774,680...9,795,376
Ensembl chr 1:9,774,680...9,795,376

G

adenylate cyclase 6

affects expression

ISO

Tamoxifen affects the expression of ADCY6 mRNA

NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:131,621,860...131,642,770

G

adenylate cyclase 7

affects expression

ISO

Tamoxifen affects the expression of ADCY7 mRNA

NCBI chr19:34,913,154...34,972,366
Ensembl chr19:34,914,322...34,936,743

G

adducin 3

increases expression

EXP

Tamoxifen results in increased expression of ADD3 protein modified form

NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:262,154,996...262,260,504

G

adhesion G protein-coupled receptor F1

decreases expression

ISO

Tamoxifen results in decreased expression of ADGRF1 mRNA

NCBI chr 9:25,158,198...25,210,744
Ensembl chr 9:25,147,588...25,208,916

G

adhesion G protein-coupled receptor G1

affects expression

ISO

Tamoxifen affects the expression of ADGRG1 mRNA

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124

G

adhesion G protein-coupled receptor G2

increases expression

ISO

Tamoxifen results in increased expression of ADGRG2 mRNA

NCBI chr X:38,106,067...38,231,286
Ensembl chr X:38,106,067...38,231,331

G

adhesion G protein-coupled receptor G3

affects expression

ISO

Tamoxifen affects the expression of ADGRG3 mRNA

NCBI chr19:9,978,450...10,007,145
Ensembl chr19:9,978,514...10,007,238

G

adhesion G protein-coupled receptor V1

increases expression
affects expression

ISO

Tamoxifen results in increased expression of ADGRV1 mRNA
Tamoxifen affects the expression of ADGRV1 mRNA

PMID:20937368 PMID:25123088

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:13,067,150...13,647,372

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

ISO

Tamoxifen affects the expression of ADH1 mRNA

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

adipogenin

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of ADIG mRNA

NCBI chr 3:167,574,963...167,580,296
Ensembl chr 3:167,574,925...167,580,297

G

adiponectin receptor 1

affects expression

ISO

Tamoxifen affects the expression of ADIPOR1 mRNA

NCBI chr13:48,411,438...48,431,251
Ensembl chr13:48,411,826...48,431,255

G

adrenomedullin

affects expression

ISO

Tamoxifen affects the expression of ADM mRNA

PMID:17555576 PMID:20937368

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

adenosine A1 receptor

affects expression

ISO

Tamoxifen affects the expression of ADORA1 mRNA

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190

G

adenosine A2B receptor

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA

NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091

G

ADP-dependent glucokinase

affects expression

ISO

Tamoxifen affects the expression of ADPGK mRNA

NCBI chr 8:68,595,194...68,623,179
Ensembl chr 8:68,595,248...68,623,178

G

ADP-ribosylhydrolase like 1

affects expression

ISO

Tamoxifen affects the expression of ADPRHL1 mRNA

NCBI chr16:82,985,355...83,017,240

G

adrenoceptor alpha 2A

increases expression

ISO

Tamoxifen results in increased expression of ADRA2A mRNA

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

increases expression

ISO

Tamoxifen results in increased expression of ADRA2B mRNA

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor beta 2

affects expression

ISO

Tamoxifen affects the expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

adrenoceptor beta 3

increases expression

ISO

Tamoxifen results in increased expression of ADRB3 mRNA

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

adenylosuccinate synthase 1

increases expression
affects expression

ISO

Tamoxifen results in increased expression of ADSS1 mRNA
Tamoxifen affects the expression of ADSS1 mRNA

PMID:20937368 PMID:25123088

NCBI chr 6:137,500,549...137,523,087
Ensembl chr 6:137,501,001...137,523,086

G

alpha-fetoprotein

affects expression
increases expression

ISO

Tamoxifen affects the expression of AFP mRNA
Tamoxifen results in increased expression of AFP mRNA

PMID:20937368 PMID:25123088

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

increases expression

ISO

Tamoxifen results in increased expression of AGAP2 mRNA

NCBI chr 7:64,782,618...64,799,624
Ensembl chr 7:64,782,612...64,799,640

G

argonaute RISC catalytic component 2

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of AGO2 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

anterior gradient 2, protein disulphide isomerase family member

multiple interactions
increases expression
decreases response to substance
affects response to substance

ISO

Tamoxifen promotes the reaction [[ESR1 protein binds to AGR2 promoter] which results in increased expression of AGR2 mRNA]; Tamoxifen promotes the reaction [ESR1 protein binds to AGR2 promoter]
Tamoxifen results in increased expression of AGR2 mRNA; Tamoxifen results in increased expression of AGR2 protein
AGR2 protein results in decreased susceptibility to Tamoxifen
AGR2 protein affects the susceptibility to Tamoxifen

PMID:20525379 PMID:20531310

NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:58,435,908...58,456,677

G

angiotensinogen

affects expression

ISO

Tamoxifen affects the expression of AGT mRNA

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

ATP/GTP binding carboxypeptidase 1

affects expression

ISO

Tamoxifen affects the expression of AGTPBP1 mRNA

NCBI chr17:5,092,108...5,244,414
Ensembl chr17:5,126,146...5,244,420

G

AHNAK nucleoprotein

increases expression

ISO

Tamoxifen results in increased expression of AHNAK mRNA

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

aryl hydrocarbon receptor

affects expression

ISO

Tamoxifen affects the expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

activator of Hsp90 ATPase activity 1

affects expression

ISO

Tamoxifen affects the expression of AHSA1 mRNA

NCBI chr 6:112,644,287...112,652,290
Ensembl chr 6:112,644,479...112,655,595

G

activator of HSP90 ATPase homolog 2

affects expression

ISO

Tamoxifen affects the expression of AHSA2 mRNA

NCBI chr14:101,677,447...101,688,706
Ensembl chr14:101,677,447...101,686,923

G

alpha-2-HS-glycoprotein

affects expression

ISO

Tamoxifen affects the expression of AHSG mRNA

NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039

G

activation-induced cytidine deaminase

multiple interactions
increases expression

ISO

Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]]
Tamoxifen results in increased expression of AICDA mRNA
Tamoxifen inhibits the reaction [Estradiol results in increased expression of AICDA mRNA]

NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:157,444,697...157,456,356

G

aryl hydrocarbon receptor-interacting protein-like 1

decreases expression

ISO

Tamoxifen results in decreased expression of AIPL1 mRNA

NCBI chr10:57,154,226...57,163,455
Ensembl chr10:57,154,226...57,163,455

G

ajuba LIM protein

affects expression

ISO

Tamoxifen affects the expression of AJUBA mRNA

NCBI chr15:31,989,796...32,000,042
Ensembl chr15:31,989,799...32,000,042

G

adenylate kinase 2

affects expression

ISO

Tamoxifen affects the expression of AK2 mRNA

NCBI chr 5:146,609,469...146,649,008
Ensembl chr 5:146,630,445...146,650,610

G

adenylate kinase 7

decreases expression

ISO

Tamoxifen results in decreased expression of AK7 mRNA

NCBI chr 6:130,376,499...130,444,674
Ensembl chr 6:130,376,550...130,444,677

G

A-kinase anchoring protein 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA

NCBI chr10:74,118,232...74,151,366
Ensembl chr10:74,119,124...74,138,190

G

A-kinase anchoring protein 12

increases expression

ISO

Tamoxifen results in increased expression of AKAP12 mRNA

NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:43,199,008...43,225,557

G

A-kinase anchoring protein 8

affects expression

ISO

Tamoxifen affects the expression of AKAP8 mRNA

NCBI chr 7:11,966,769...11,983,056
Ensembl chr 7:11,966,772...11,982,900

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
affects expression
increases activity
increases phosphorylation

ISO

AKT1 protein inhibits the reaction [Tamoxifen analog results in increased activity of CASP3 protein]; AKT1 protein inhibits the reaction [Tamoxifen analog results in increased activity of CASP9 protein]; AKT1 protein inhibits the reaction [Tamoxifen results in increased activity of CASP3 protein]; AKT1 protein inhibits the reaction [Tamoxifen results in increased activity of CASP9 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; TP53 protein inhibits the reaction [Tamoxifen results in decreased phosphorylation of AKT1 protein]
Tamoxifen results in decreased phosphorylation of and results in decreased activity of AKT1 protein
Tamoxifen affects the expression of AKT1 mRNA
[Tamoxifen results in increased activity of AKT1 protein] which results in increased activity of MYC protein; [Tamoxifen results in increased activity of AKT1 protein] which results in increased activity of RPS6KB1 protein; Tamoxifen results in increased activity of AKT1 protein
Tamoxifen analog results in increased phosphorylation of AKT1 protein

PMID:14990993 PMID:17555576 PMID:19393235 PMID:19549922 PMID:20372086 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aminolevulinate dehydratase

affects expression

ISO

Tamoxifen affects the expression of ALAD mRNA

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

5'-aminolevulinate synthase 1

affects expression

ISO

Tamoxifen affects the expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

albumin

multiple interactions
decreases expression
decreases secretion

EXP
ISO

gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of ALB protein]
Tamoxifen results in decreased secretion of ALB protein

PMID:16837906 PMID:19279558

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

activated leukocyte cell adhesion molecule

affects expression

ISO

Tamoxifen affects the expression of ALCAM mRNA

NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876

G

aldehyde dehydrogenase 1 family, member B1

decreases expression
affects response to substance

ISO

Tamoxifen results in decreased expression of ALDH1B1 mRNA
ALDH1B1 protein affects the susceptibility to Tamoxifen

PMID:25123088 PMID:33007288

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365

G

aldehyde dehydrogenase 3 family, member A2

affects expression

ISO

Tamoxifen affects the expression of ALDH3A2 mRNA

NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648

G

aldehyde dehydrogenase 7 family, member A1

affects expression

ISO

Tamoxifen affects the expression of ALDH7A1 mRNA

NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467

G

aldolase, fructose-bisphosphate A

increases expression

EXP

Tamoxifen results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

ALG2, alpha-1,3/1,6-mannosyltransferase

increases expression

ISO

Tamoxifen results in increased expression of ALG2 mRNA

NCBI chr 5:66,564,328...66,568,887
Ensembl chr 5:66,564,330...66,568,887

G

ALG9, alpha-1,2-mannosyltransferase

affects expression

ISO

Tamoxifen affects the expression of ALG9 mRNA

NCBI chr 8:60,013,429...60,085,159
Ensembl chr 8:60,009,618...60,085,054

G

arachidonate 12-lipoxygenase, 12S type

affects expression

ISO

Tamoxifen affects the expression of ALOX12 mRNA

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199

G

arachidonate 5-lipoxygenase

multiple interactions
increases expression

ISO

[Tamoxifen results in increased expression of ALOX5 protein] which results in increased abundance of Leukotriene B4

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

arachidonate 5-lipoxygenase activating protein

affects expression

ISO

Tamoxifen affects the expression of ALOX5AP mRNA

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

alkaline phosphatase, biomineralization associated

affects expression
multiple interactions
increases activity
decreases expression

ISO
EXP

Tamoxifen affects the expression of ALPL mRNA
zinc chloride inhibits the reaction [Tamoxifen results in increased activity of ALPL protein]
Tamoxifen results in decreased expression of ALPL mRNA

PMID:20937368 PMID:25123088 PMID:31532279

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

alpha-1-microglobulin/bikunin precursor

affects expression

ISO

Tamoxifen affects the expression of AMBP mRNA

NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850

G

APC membrane recruitment protein 2

increases expression

ISO

Tamoxifen results in increased expression of AMER2 mRNA

NCBI chr15:38,701,509...38,711,817
Ensembl chr15:38,701,657...38,705,633

G

anti-Mullerian hormone receptor type 2

decreases expression

ISO

Tamoxifen results in decreased expression of AMHR2 mRNA

NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:135,457,922...135,471,104

G

adhesion molecule with Ig like domain 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA

NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218

G

AMMECR1 like

affects expression

ISO

Tamoxifen affects the expression of AMMECR1L mRNA

NCBI chr18:23,661,649...23,685,391
Ensembl chr18:23,661,341...23,685,649

G

archaelysin family metallopeptidase 2

affects expression

ISO

Tamoxifen affects the expression of AMZ2 mRNA

NCBI chr10:94,901,053...94,911,629
Ensembl chr10:94,901,129...94,911,627

G

anaphase-promoting complex subunit 5

affects expression

ISO

Tamoxifen affects the expression of ANAPC5 mRNA

NCBI chr12:39,409,519...39,442,518
Ensembl chr12:39,385,399...39,442,762

G

anaphase promoting complex subunit 7

affects expression

ISO

Tamoxifen affects the expression of ANAPC7 mRNA

NCBI chr12:39,793,518...39,821,614
Ensembl chr12:39,794,349...39,821,066

G

angel homolog 2

affects expression

ISO

Tamoxifen affects the expression of ANGEL2 mRNA

NCBI chr13:105,041,727...105,060,640
Ensembl chr13:105,041,728...105,060,640

G

angiopoietin-like 2

affects expression

ISO

Tamoxifen affects the expression of ANGPTL2 mRNA

NCBI chr 3:36,914,876...36,944,715
Ensembl chr 3:36,914,745...36,945,876

G

angiopoietin-like 3

decreases expression

ISO

Tamoxifen results in decreased expression of ANGPTL3 mRNA

NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444

G

ankyrin 1

affects expression

ISO

Tamoxifen affects the expression of ANK1 mRNA

NCBI chr16:75,578,824...75,757,464
Ensembl chr16:75,578,824...75,757,464

G

ANKH inorganic pyrophosphate transport regulator

affects expression

ISO

Tamoxifen affects the expression of ANK mRNA

NCBI chr 2:79,883,350...80,011,222
Ensembl chr 2:79,883,544...80,011,699

G

ankyrin repeat domain 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA

NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:243,228,448...243,263,751

G

ankyrin repeat domain 23

affects expression

ISO

Tamoxifen affects the expression of ANKRD23 mRNA

NCBI chr 9:46,269,107...46,274,578
Ensembl chr 9:46,269,107...46,274,510

G

ankyrin repeat domain 28

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA

NCBI chr16:6,924,868...7,056,593
Ensembl chr16:6,924,882...7,056,593

G

ankyrin repeat domain 46

affects expression

ISO

Tamoxifen affects the expression of ANKRD46 mRNA

NCBI chr 7:69,532,303...69,553,311
Ensembl chr 7:69,532,304...69,545,421

G

ankyrin repeat and sterile alpha motif domain containing 3

affects expression

ISO

Tamoxifen affects the expression of ANKS3 mRNA

NCBI chr10:11,121,504...11,142,261
Ensembl chr10:11,121,553...11,142,491

G

anillin, actin binding protein

affects expression

ISO

Tamoxifen affects the expression of ANLN mRNA

NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:29,134,222...29,197,513

G

anoctamin 1

affects expression

ISO

Tamoxifen affects the expression of ANO1 mRNA

NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:209,180,755...209,329,550

G

alanyl aminopeptidase, membrane

affects expression

ISO

Tamoxifen affects the expression of ANPEP mRNA

NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101

G

annexin A2

affects expression

ISO

Tamoxifen affects the expression of ANXA2 mRNA

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

annexin A3

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of ANXA3 mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of ANXA3 mRNA

PMID:17555576 PMID:17630414

NCBI chr14:13,031,675...13,085,678
Ensembl chr14:13,023,762...13,085,849

G

adaptor related protein complex 1 subunit gamma 1

affects expression

ISO

Tamoxifen affects the expression of AP1G1 mRNA

NCBI chr19:54,654,101...54,740,586
Ensembl chr19:54,620,807...54,740,586

G

adaptor related protein complex 1 subunit mu 2

affects expression

ISO

Tamoxifen affects the expression of AP1M2 mRNA

NCBI chr 8:28,114,748...28,132,767
Ensembl chr 8:28,114,748...28,132,642

G

adaptor related protein complex 1 subunit sigma 1

affects expression
decreases expression

ISO

Tamoxifen affects the expression of AP1S1 mRNA
Tamoxifen results in decreased expression of AP1S1 mRNA

PMID:17175557 PMID:17555576 PMID:17567588

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483

G

adaptor related protein complex 2 subunit alpha 1

affects expression

ISO

Tamoxifen affects the expression of AP2A1 mRNA

NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:104,520,792...104,550,655

G

adaptor related protein complex 2 subunit mu 1

increases expression

ISO

Tamoxifen results in increased expression of AP2M1 mRNA

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:93,859,690...93,868,480

G

adaptor related protein complex 3 subunit mu 1

affects expression

ISO

Tamoxifen affects the expression of AP3M1 mRNA

NCBI chr15:3,285,591...3,314,139
Ensembl chr15:3,295,444...3,313,104

G

adaptor related protein complex 3 subunit sigma 1

affects expression

ISO

Tamoxifen affects the expression of AP3S1 mRNA

NCBI chr18:41,649,321...41,718,221
Ensembl chr18:41,648,796...41,767,641

G

amyloid beta precursor protein binding family A member 3

increases expression

ISO

Tamoxifen results in increased expression of APBA3 mRNA

NCBI chr 7:9,096,936...9,103,457
Ensembl chr 7:9,095,975...9,101,909

G

amyloid beta precursor protein binding family B member 3

affects expression

ISO

Tamoxifen affects the expression of APBB3 mRNA

NCBI chr18:28,547,205...28,554,383
Ensembl chr18:28,547,205...28,554,383

G

APC regulator of WNT signaling pathway 2

decreases expression

ISO

Tamoxifen results in decreased expression of APC2 mRNA

NCBI chr 7:10,043,010...10,065,037
Ensembl chr 7:10,043,010...10,065,210

G

amyloid P component, serum

decreases expression

ISO

Tamoxifen results in decreased expression of APCS protein
Tamoxifen results in decreased expression of APCS mRNA

PMID:11156862 PMID:25123088

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression
affects expression

EXP
ISO

Tamoxifen results in increased expression of APEX1 mRNA
Tamoxifen affects the expression of APEX1 mRNA

PMID:12841865 PMID:17555576

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

apurinic/apyrimidinic endodeoxyribonuclease 2

increases expression
affects expression

ISO

Tamoxifen results in increased expression of APEX2 mRNA
Tamoxifen affects the expression of APEX2 mRNA

PMID:15590111 PMID:17555576

NCBI chr X:22,914,943...22,937,713
Ensembl chr X:22,914,944...22,936,011

G

amyloid beta precursor like protein 1

affects expression

ISO

Tamoxifen affects the expression of APLP1 mRNA

NCBI chr 1:94,824,330...94,834,705
Ensembl chr 1:94,824,072...94,834,610

G

apolipoprotein A4

affects expression

ISO

Tamoxifen affects the expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein B

decreases expression

EXP

Tamoxifen results in decreased expression of APOB mRNA

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein C1

affects expression

ISO

Tamoxifen affects the expression of APOC1 mRNA

NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:88,474,663...88,478,155

G

apolipoprotein D

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in decreased expression of APOD protein]

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

apolipoprotein E

affects response to substance
affects expression

ISO

APOE gene polymorphism affects the susceptibility to Tamoxifen
Tamoxifen affects the expression of APOE mRNA

PMID:17555576 PMID:19103187

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

apolipoprotein L7A

decreases expression

ISO

Tamoxifen results in decreased expression of APOL7A mRNA

Ensembl chr 7:111,011,645...111,017,084

G

apolipoprotein L9a

decreases expression

ISO

Tamoxifen results in decreased expression of APOL9A mRNA

NCBI chr 7:111,021,452...111,030,380
Ensembl chr 7:111,021,453...111,028,213

G

amyloid beta precursor protein

affects expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of APP mRNA
Tamoxifen results in decreased expression of APP mRNA

PMID:17555576 PMID:19400957

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

adenine phosphoribosyl transferase

affects expression

ISO

Tamoxifen affects the expression of APRT mRNA

NCBI chr19:67,534,737...67,537,027

G

aquaporin 1

affects expression
decreases expression
multiple interactions

ISO

Tamoxifen affects the expression of AQP1 mRNA
Tamoxifen results in decreased expression of AQP1 mRNA
ESR1 protein mutant form inhibits the reaction [Tamoxifen results in decreased expression of AQP1 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP1 mRNA]

PMID:17555576 PMID:23213263

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

aquaporin 5

affects expression

ISO

Tamoxifen affects the expression of AQP5 mRNA

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

aquaporin 7

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of AQP7 mRNA

NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:60,967,558...60,982,618

G

aquaporin 9

multiple interactions
decreases expression

ISO

Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 protein]
Tamoxifen results in decreased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

androgen receptor

decreases response to substance
decreases expression
affects expression
multiple interactions
affects binding
decreases activity

ISO
EXP

AR mRNA results in decreased susceptibility to Tamoxifen
Tamoxifen results in decreased expression of AR protein
Tamoxifen affects the expression of AR mRNA
[Tamoxifen co-treated with Estradiol] results in decreased expression of AR protein
Tamoxifen binds to AR protein
Tamoxifen inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]
Tamoxifen results in decreased activity of AR protein

PMID:14565775 PMID:14751673 PMID:15316697 PMID:19533338 PMID:20937368 More...

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

affects expression

ISO

Tamoxifen affects the expression of CENTD2 mRNA

NCBI chr 1:165,160,701...165,226,219
Ensembl chr 1:165,160,678...165,226,218

G

archain 1

affects expression

ISO

Tamoxifen affects the expression of ARCN1 mRNA

NCBI chr 8:53,954,401...53,979,005
Ensembl chr 8:53,954,404...53,979,005

G

amphiregulin

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of AREG mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of AREG mRNA; Tamoxifen inhibits the reaction [Estradiol results in increased expression of AREG mRNA]

PMID:16202921 PMID:19059307 PMID:24758408

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

ARF GTPase 1

affects expression

ISO

Tamoxifen affects the expression of ARF1 mRNA

NCBI chr10:44,497,543...44,513,994

G

ADP-ribosylation factor 2

affects expression

ISO

Tamoxifen affects the expression of ARF2 mRNA

NCBI chr10:89,367,843...89,389,644
Ensembl chr10:89,368,044...89,389,651

G

ARF GTPase 4

affects expression

ISO

Tamoxifen affects the expression of ARF4 mRNA

NCBI chr16:1,903,238...1,920,012
Ensembl chr16:1,903,371...1,920,011

G

ARF related protein 1

affects expression

ISO

Tamoxifen affects the expression of ARFRP1 mRNA

NCBI chr 3:188,844,013...188,851,473
Ensembl chr 3:188,845,511...188,851,431

G

arginase 1

affects expression

ISO

Tamoxifen affects the expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

arginase 2

increases expression

ISO

Tamoxifen results in increased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375

G

Rho GTPase activating protein 10

increases expression

ISO

Tamoxifen results in increased expression of ARHGAP10 mRNA

NCBI chr19:47,352,783...47,614,532
Ensembl chr19:47,352,276...47,614,531

G

Rho GTPase activating protein 18

affects expression

ISO

Tamoxifen affects the expression of ARHGAP18 mRNA

NCBI chr 1:20,222,948...20,456,827
Ensembl chr 1:20,222,954...20,456,670

G

Rho GTPase activating protein 22

affects expression

ISO

Tamoxifen affects the expression of ARHGAP22 mRNA

NCBI chr16:8,480,222...8,637,823
Ensembl chr16:8,479,956...8,637,822

G

Rho GTPase activating protein 24

affects expression

ISO

Tamoxifen affects the expression of ARHGAP24 mRNA

NCBI chr14:7,105,200...7,488,437
Ensembl chr14:7,105,200...7,528,950

G

Rho GTPase activating protein 29

affects expression

ISO

Tamoxifen affects the expression of ARHGAP29 mRNA

NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:212,755,803...212,986,729

G

Rho GTPase activating protein 45

affects expression

ISO

Tamoxifen affects the expression of ARHGAP45 mRNA

NCBI chr 7:10,325,515...10,340,955
Ensembl chr 7:10,325,539...10,341,890

G

Rho guanine nucleotide exchange factor 19

decreases expression

ISO

Tamoxifen results in decreased expression of ARHGEF19 mRNA

NCBI chr 5:158,818,840...158,837,196
Ensembl chr 5:158,818,932...158,837,196

G

Rho guanine nucleotide exchange factor 25

affects expression

ISO

Tamoxifen affects the expression of ARHGEF25 mRNA

NCBI chr 7:64,891,260...64,898,382
Ensembl chr 7:64,890,879...64,898,697

G

Rho guanine nucleotide exchange factor 7

affects expression

ISO

Tamoxifen affects the expression of ARHGEF7 mRNA

NCBI chr16:84,373,123...84,484,759
Ensembl chr16:84,373,123...84,484,597

G

AT-rich interaction domain 3B

affects expression

ISO

Tamoxifen affects the expression of ARID3B mRNA

NCBI chr 8:67,089,141...67,136,764
Ensembl chr 8:67,083,802...67,152,245

G

AT-rich interaction domain 5B

affects expression

ISO

Tamoxifen affects the expression of ARID5B mRNA

PMID:14699072 PMID:20937368

NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686

G

ARF like GTPase 15

increases expression

ISO

Tamoxifen results in increased expression of ARL15 mRNA

NCBI chr 2:47,171,377...47,555,666
Ensembl chr 2:47,094,900...47,555,666

G

ARF like GTPase 2

affects expression

ISO

Tamoxifen affects the expression of ARL2 mRNA

NCBI chr 1:212,863,422...212,875,425
Ensembl chr 1:212,863,423...212,875,373

G

ARF like GTPase 2 binding protein

affects expression

ISO

Tamoxifen affects the expression of ARL2BP mRNA

NCBI chr19:10,342,895...10,352,529
Ensembl chr19:10,342,895...10,352,514

G

ARF like GTPase 3

affects expression

ISO

Tamoxifen affects the expression of ARL3 mRNA

NCBI chr 1:255,342,078...255,388,087
Ensembl chr 1:255,342,076...255,388,279

G

ARF like GTPase 4A

affects expression

ISO

Tamoxifen affects the expression of ARL4A mRNA

NCBI chr 6:62,809,287...62,811,297
Ensembl chr 6:62,804,548...62,820,760

G

ARF like GTPase 4C

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA

NCBI chr 9:96,748,075...96,751,510
Ensembl chr 9:96,745,069...96,752,772

G

armadillo repeat containing 10

affects expression

ISO

Tamoxifen affects the expression of ARMC10 mRNA

NCBI chr 4:14,291,211...14,306,799
Ensembl chr 4:14,291,211...14,306,817

G

aryl hydrocarbon receptor nuclear translocator

affects expression

ISO

Tamoxifen affects the expression of ARNT mRNA

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

actin related protein 2/3 complex, subunit 3

affects expression

ISO

Tamoxifen affects the expression of ARPC3 mRNA

NCBI chr12:39,833,569...39,847,436
Ensembl chr12:39,833,569...39,847,436

G

arrestin, beta 1

affects expression

ISO

Tamoxifen affects the expression of ARRB1 mRNA

NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859

G

arrestin domain containing 2

increases expression

ISO

Tamoxifen results in increased expression of ARRDC2 mRNA

NCBI chr16:18,635,883...18,640,019
Ensembl chr16:18,635,883...18,640,158

G

arylsulfatase A

affects expression
increases expression

ISO

Tamoxifen affects the expression of ARSA mRNA
Tamoxifen results in increased expression of ARSA mRNA

PMID:17555576 PMID:25123088

NCBI chr 7:122,422,971...122,426,971
Ensembl chr 7:122,422,982...122,428,401

G

ADP-ribosyltransferase 1

decreases expression

ISO

Tamoxifen results in decreased expression of ART1 mRNA

NCBI chr 1:165,890,032...165,899,154
Ensembl chr 1:165,890,086...165,899,146

G

ADP-ribosyltransferase 3

affects expression

ISO

Tamoxifen affects the expression of ART3 mRNA

NCBI chr14:15,921,540...16,003,764
Ensembl chr14:15,921,395...15,949,806

G

artemin

multiple interactions
decreases response to substance

ISO

ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ARTN mRNA]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]
ARTN protein results in decreased susceptibility to Tamoxifen

PMID:20305694 PMID:24758408

NCBI chr 5:136,750,188...136,755,645
Ensembl chr 5:136,750,188...136,753,457

G

arsenite methyltransferase

affects expression

ISO

Tamoxifen affects the expression of AS3MT mRNA

NCBI chr 1:255,536,879...255,569,245
Ensembl chr 1:255,537,109...255,569,249

G

N-acylsphingosine amidohydrolase 1

increases expression

ISO

Tamoxifen results in increased expression of ASAH1 mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

ankyrin repeat and SOCS box-containing 13

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ASB13 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA

PMID:19059307 PMID:20937368

NCBI chr17:71,474,531...71,493,238
Ensembl chr17:71,474,531...71,505,633

G

ankyrin repeat and SOCS box-containing 6

affects expression

ISO

Tamoxifen affects the expression of ASB6 mRNA

NCBI chr 3:34,508,390...34,513,033
Ensembl chr 3:34,508,140...34,513,033

G

activating signal cointegrator 1 complex subunit 2

affects expression

ISO

Tamoxifen affects the expression of ASCC2 mRNA

NCBI chr14:83,726,975...83,771,312
Ensembl chr14:83,727,049...83,771,316

G

achaete-scute family bHLH transcription factor 1

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of ASCL1 mRNA

NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:23,790,360...23,798,231

G

achaete-scute family bHLH transcription factor 3

increases expression

ISO

Tamoxifen results in increased expression of ASCL3 mRNA

NCBI chr 1:173,190,061...173,194,302
Ensembl chr 1:173,190,228...173,192,197

G

anti-silencing function 1A histone chaperone

affects expression

ISO

Tamoxifen affects the expression of ASF1A mRNA

NCBI chr20:33,436,632...33,451,478
Ensembl chr20:33,436,707...33,449,639

G

anti-silencing function 1B histone chaperone

affects expression

ISO

Tamoxifen affects the expression of ASF1B mRNA

NCBI chr19:41,085,786...41,100,352
Ensembl chr19:41,086,114...41,100,352

G

asialoglycoprotein receptor 1

affects expression

ISO

Tamoxifen affects the expression of ASGR1 mRNA

NCBI chr10:55,274,299...55,278,323
Ensembl chr10:55,274,706...55,278,322

G

asparagine synthetase (glutamine-hydrolyzing)

affects expression
increases expression

ISO

Tamoxifen affects the expression of ASNS mRNA
Tamoxifen results in increased expression of ASNS mRNA

PMID:17175557 PMID:17555576 PMID:17567588

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartate-beta-hydroxylase

affects expression

ISO

Tamoxifen affects the expression of ASPH mRNA

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:27,398,949...27,611,215

G

arginyltransferase 1

affects expression

ISO

Tamoxifen affects the expression of ATE1 mRNA

NCBI chr 1:194,391,843...194,514,284
Ensembl chr 1:194,391,843...194,511,348

G

activating transcription factor 2

multiple interactions
affects expression
increases phosphorylation

ISO

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein]
Tamoxifen affects the expression of ATF2 mRNA

PMID:14645110 PMID:17555576

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

activating transcription factor 3

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of ATF3 mRNA
Tamoxifen results in increased expression of ATF3 mRNA

PMID:15604281 PMID:19059307

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of ATF4 mRNA
Tamoxifen results in increased expression of ATF4 mRNA

PMID:17555576 PMID:19400957

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 5

affects expression

ISO

Tamoxifen affects the expression of ATF5 mRNA

PMID:17555576 PMID:20937368

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

activating transcription factor 7 interacting protein

increases expression

ISO

Tamoxifen results in increased expression of ATF7IP mRNA

NCBI chr 4:171,117,122...171,202,871
Ensembl chr 4:171,117,122...171,202,867

G

autophagy related 2B

affects expression

ISO

Tamoxifen affects the expression of ATG2B mRNA

NCBI chr 6:130,286,979...130,357,109
Ensembl chr 6:130,286,986...130,357,109

G

autophagy related 7

affects expression

ISO

Tamoxifen affects the expression of ATG7 mRNA

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319

G

ATPase phospholipid transporting 11C

affects expression

ISO

Tamoxifen affects the expression of ATP11C mRNA

NCBI chr X:143,600,763...143,788,407
Ensembl chr X:143,600,767...143,788,432

G

ATPase H+/K+ transporting non-gastric alpha2 subunit

decreases expression

ISO

Tamoxifen results in decreased expression of ATP12A mRNA

NCBI chr15:34,559,209...34,583,866
Ensembl chr15:34,559,209...34,583,866

G

ATPase Na+/K+ transporting subunit beta 1

affects expression

ISO

Tamoxifen affects the expression of ATP1B1 mRNA

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

multiple interactions

EXP

Tamoxifen inhibits the reaction [Doxorubicin affects the activity of ATP2A1 protein]

NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:190,457,198...190,475,423

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

affects expression

ISO

Tamoxifen affects the expression of ATP2A2 mRNA

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATPase plasma membrane Ca2+ transporting 1

affects expression

ISO

Tamoxifen affects the expression of ATP2B1 mRNA

NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:35,622,461...35,731,904

G

ATPase plasma membrane Ca2+ transporting 2

decreases expression

ISO

Tamoxifen results in decreased expression of ATP2B2 mRNA

NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:148,450,207...148,696,239

G

ATP synthase F1 subunit alpha

affects expression

ISO

Tamoxifen affects the expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATP synthase F1 subunit beta

increases expression
affects expression

ISO
EXP

Tamoxifen results in increased expression of ATP5F1B mRNA
Tamoxifen affects the expression of ATP5F1B mRNA

PMID:17555576 PMID:19400957 PMID:20211987

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase membrane subunit c locus 1

increases expression
affects expression

EXP
ISO

Tamoxifen results in increased expression of ATP5MC1 mRNA
Tamoxifen affects the expression of ATP5MC1 mRNA

PMID:17555576 PMID:19400957

NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,520,765...81,523,363

G

ATP synthase peripheral stalk subunit OSCP

affects expression

ISO

Tamoxifen affects the expression of ATP5PO mRNA

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:44,651,173...44,657,520

G

ATPase H+ transporting V0 subunit a1

increases expression

ISO

Tamoxifen results in increased expression of ATP6V0A1 mRNA

NCBI chr10:86,436,089...86,490,185
Ensembl chr10:86,436,141...86,490,181

G

ATPase H+ transporting V0 subunit D2

decreases expression

ISO

Tamoxifen results in decreased expression of ATP6V0D2 mRNA

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

ATPase, H+ transporting V0 subunit e2

affects expression

ISO

Tamoxifen affects the expression of ATP6V0E2 mRNA

NCBI chr 4:78,815,771...78,818,919
Ensembl chr 4:78,813,129...78,819,680

G

ATPase H+ transporting V1 subunit D

affects expression

ISO

Tamoxifen affects the expression of ATP6V1D mRNA

NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:103,389,783...103,405,346

G

ATPase phospholipid transporting 9A (putative)

affects expression

ISO

Tamoxifen affects the expression of ATP9A mRNA

NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:177,779,203...178,023,661

G

ataxin 3

affects expression

ISO

Tamoxifen affects the expression of ATXN3 mRNA

NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:126,839,327...126,872,781

G

aurora kinase B

affects expression

ISO

Tamoxifen affects the expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

arginine vasopressin-induced 1

affects expression

ISO

Tamoxifen affects the expression of AVPI1 mRNA

NCBI chr 1:250,879,530...250,885,448
Ensembl chr 1:250,879,530...250,885,704

G

arginine vasopressin receptor 1A

affects expression

ISO

Tamoxifen affects the expression of AVPR1A mRNA

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:59,999,738...60,003,837

G

antizyme inhibitor 1

affects expression

ISO

Tamoxifen affects the expression of AZIN1 mRNA

NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:71,539,711...71,566,515

G

beta-2 microglobulin

increases expression
affects expression

ISO

Tamoxifen results in increased expression of B2M mRNA
Tamoxifen affects the expression of B2M mRNA

PMID:17555576 PMID:19155303

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356

G

Beta-1,3-galactosyltransferase 5

decreases expression

ISO

Tamoxifen results in decreased expression of B3GALT5 protein

NCBI chr11:49,053,959...49,100,398
Ensembl chr11:49,006,560...49,101,283

G

beta-1,4-galactosyltransferase 1

affects expression

ISO

Tamoxifen affects the expression of B4GALT1 mRNA

NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:60,731,602...60,778,445

G

beta-1,4-galactosyltransferase 5

increases expression

ISO

Tamoxifen results in increased expression of B4GALT5 mRNA

NCBI chr 3:176,437,073...176,453,001
Ensembl chr 3:176,437,073...176,488,978

G

BTB domain and CNC homolog 1

affects expression

ISO

Tamoxifen affects the expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BTB domain and CNC homolog 2

affects expression
decreases expression

ISO

Tamoxifen affects the expression of BACH2 mRNA
Tamoxifen results in decreased expression of BACH2 mRNA

PMID:17555576 PMID:20937368

NCBI chr 5:51,428,802...51,779,030
Ensembl chr 5:51,434,870...51,774,234

G

BCL2-associated agonist of cell death

increases phosphorylation

ISO

Tamoxifen results in increased phosphorylation of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BAG cochaperone 1

affects response to substance

ISO

BAG1 protein affects the susceptibility to Tamoxifen

NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:60,864,476...60,878,161

G

BAR/IMD domain containing adaptor protein 2 like 1

affects expression

ISO

Tamoxifen affects the expression of BAIAP2L1 mRNA

NCBI chr12:15,364,090...15,453,602
Ensembl chr12:15,364,109...15,453,605

G

barrier to autointegration nuclear assembly factor 1

affects expression

ISO

Tamoxifen affects the expression of BANF1 mRNA

NCBI chr 1:212,101,523...212,103,568
Ensembl chr 1:212,101,523...212,103,552

G

BRCA1 associated RING domain 1

increases expression

ISO

Tamoxifen results in increased expression of BARD1 mRNA

NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:80,069,960...80,176,873

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression
affects expression

ISO

[Tamoxifen co-treated with AG 1879] affects the localization of BAX protein; [Tamoxifen co-treated with TNFSF10 protein] results in increased expression of BAX protein; naringenin inhibits the reaction [Tamoxifen results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [Doxorubicin results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [Mitomycin results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [naringenin results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [Vindesine results in decreased expression of BAX mRNA]
Tamoxifen results in increased expression of BAX mRNA
Tamoxifen inhibits the reaction [manganese chloride results in increased expression of BAX protein]
Tamoxifen affects the expression of BAX mRNA

PMID:17186241 PMID:17555576 PMID:17767197 PMID:19757172 PMID:29183790 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bromodomain adjacent to zinc finger domain, 1A

affects expression

ISO

Tamoxifen affects the expression of BAZ1A mRNA

NCBI chr 6:78,124,872...78,247,672
Ensembl chr 6:78,124,872...78,247,648

G

Bcl-2 binding component 3

affects expression
decreases expression

ISO

Tamoxifen affects the expression of BBC3 mRNA
Tamoxifen results in decreased expression of BBC3 mRNA

PMID:20937368 PMID:25123088

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

Bardet-Biedl syndrome 2

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of BBS2 mRNA

NCBI chr19:10,915,566...10,950,911
Ensembl chr19:10,915,476...10,950,921

G

BCAR1 scaffold protein, Cas family member

decreases response to substance
multiple interactions

ISO

BCAR1 protein results in decreased susceptibility to Tamoxifen
Tamoxifen promotes the reaction [BCAR1 protein mutant form results in decreased expression of BCL2 protein]

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

BCAR3 adaptor protein, NSP family member

affects response to substance

ISO

BCAR3 protein affects the susceptibility to Tamoxifen

NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:213,209,893...213,323,302

G

branched chain amino acid transaminase 1

affects expression

ISO

Tamoxifen affects the expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression

ISO

Tamoxifen results in decreased expression of BCKDHA mRNA

NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:90,261,629...90,295,749

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO
EXP

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 protein; [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [Tamoxifen co-treated with AG 1879] results in increased expression of BCL2 protein; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]; RELA protein inhibits the reaction [Tamoxifen results in decreased expression of BCL2 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]; Tamoxifen inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; Tamoxifen promotes the reaction [BCAR1 protein mutant form results in decreased expression of BCL2 protein]; Tamoxifen promotes the reaction [Doxorubicin results in increased expression of BCL2 mRNA]; Tamoxifen promotes the reaction [Mitomycin results in increased expression of BCL2 mRNA]; Tamoxifen promotes the reaction [Vindesine results in increased expression of BCL2 mRNA]; TP53 protein promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]; YC137 inhibits the reaction [ARTN protein inhibits the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]]
Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein]
[BCL2 co-treated with Tamoxifen] results in increased expression of FASL protein; [BCL2 co-treated with Tamoxifen] results in increased phosphorylation of JUN protein; [Tamoxifen results in increased expression of MIR16-2 mRNA] which results in decreased expression of BCL2 protein
Tamoxifen results in decreased expression of BCL2 mRNA; Tamoxifen results in decreased expression of BCL2 protein

PMID:10785588 PMID:15606891 PMID:16051634 PMID:17186241 PMID:17343880 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

multiple interactions

ISO

Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of BCL2L11 protein]

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

BCL3, transcription coactivator

affects expression

ISO

Tamoxifen affects the expression of BCL3 mRNA

NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368

G

BCL6, transcription repressor

increases expression
affects expression

ISO

Tamoxifen results in increased expression of BCL6 mRNA
Tamoxifen affects the expression of BCL6 mRNA

PMID:15604281 PMID:20937368 PMID:25123088

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

BCL6B, transcription repressor

affects expression

ISO

Tamoxifen affects the expression of BCL6B mRNA

NCBI chr10:55,439,566...55,444,631
Ensembl chr10:55,432,382...55,444,631

G

BAF chromatin remodeling complex subunit BCL7B

affects expression

ISO

Tamoxifen affects the expression of BCL7B mRNA

NCBI chr12:27,133,412...27,146,631
Ensembl chr12:27,133,412...27,146,636

G

BCL2-associated transcription factor 1

affects expression

ISO

Tamoxifen affects the expression of BCLAF1 mRNA

NCBI chr 1:16,904,572...16,937,106
Ensembl chr 1:16,914,118...16,936,801

G

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

affects expression

ISO

Tamoxifen affects the expression of BCS1L mRNA

NCBI chr 9:83,614,045...83,618,052
Ensembl chr 9:83,613,975...83,618,257

G

brain-derived neurotrophic factor

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of BDNF mRNA
Tamoxifen results in decreased expression of and results in decreased cleavage of BDNF mRNA

PMID:14699072 PMID:37392961

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

BEN domain containing 5

affects expression

ISO

Tamoxifen affects the expression of BEND5 mRNA

NCBI chr 5:131,519,214...131,565,228
Ensembl chr 5:131,519,214...131,762,906

G

brain expressed X-linked 2

affects expression

ISO

Tamoxifen affects the expression of BEX1 mRNA

NCBI chr X:103,811,458...103,812,986
Ensembl chr X:103,808,935...103,812,092

G

brain expressed, X-linked 4

decreases expression

ISO

Tamoxifen results in decreased expression of BEX4 mRNA

NCBI chr X:103,923,609...103,925,041
Ensembl chr X:103,923,338...103,925,496

G

bone gamma-carboxyglutamate protein

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of BGLAP mRNA

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

biglycan

affects expression

ISO

Tamoxifen affects the expression of BGN mRNA

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799

G

basic helix-loop-helix family, member e40

affects expression

ISO

Tamoxifen affects the expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

BICD cargo adaptor 2

affects expression

ISO

Tamoxifen affects the expression of BICD2 mRNA

NCBI chr17:15,449,011...15,511,423
Ensembl chr17:15,435,894...15,511,305

G

BH3 interacting domain death agonist

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with TNFSF10 protein] results in increased cleavage of BID protein
Tamoxifen results in increased expression of BID mRNA

PMID:17767197 PMID:38779996

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2-interacting killer

multiple interactions

ISO

ESR2 protein promotes the reaction [Tamoxifen results in increased expression of BIK protein]

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

baculoviral IAP repeat-containing 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

decreases response to substance
affects expression
decreases expression
multiple interactions

ISO

BIRC5 protein results in decreased susceptibility to Tamoxifen; BIRC5 results in decreased susceptibility to Tamoxifen
Tamoxifen affects the expression of BIRC5 mRNA
Tamoxifen results in decreased expression of BIRC5 mRNA; Tamoxifen results in decreased expression of BIRC5 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 protein; Sirolimus promotes the reaction [Tamoxifen results in decreased expression of BIRC5 protein]

PMID:17555576 PMID:18815881 PMID:19931998 PMID:22046442

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

biogenesis of lysosomal organelles complex-1, subunit 1

affects expression

ISO

Tamoxifen affects the expression of BLOC1S1 mRNA

NCBI chr 7:1,931,985...1,935,614
Ensembl chr 7:1,925,335...1,936,049

G

biogenesis of lysosomal organelles complex 1 subunit 6

affects expression

ISO

Tamoxifen affects the expression of BLOC1S6 mRNA

NCBI chr 3:130,269,979...130,280,109
Ensembl chr 3:130,268,442...130,281,360

G

biliverdin reductase A

affects expression

ISO

Tamoxifen affects the expression of BLVRA mRNA

NCBI chr 3:134,793,397...134,819,367
Ensembl chr 3:134,794,203...134,819,785

G

bone morphogenetic protein 2

multiple interactions

ISO
EXP

Tamoxifen inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]
[bexarotene co-treated with Tamoxifen] results in decreased expression of BMP2 mRNA

PMID:17513867 PMID:17630414

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

BMP-2 inducible kinase

affects expression
decreases expression

ISO

Tamoxifen affects the expression of BMP2K mRNA
Tamoxifen results in decreased expression of BMP2K mRNA

PMID:14699072 PMID:17555576

NCBI chr14:12,785,169...12,882,676
Ensembl chr14:12,785,169...12,882,657

G

bone morphogenetic protein 5

affects expression

ISO

Tamoxifen affects the expression of BMP5 mRNA

NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:85,396,925...85,520,189

G

bone morphogenetic protein 7

affects expression
increases expression

ISO

Tamoxifen affects the expression of BMP7 mRNA
Tamoxifen results in increased expression of BMP7 mRNA

PMID:14699072 PMID:25123088

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137

G

basonuclin zinc finger protein 2

increases expression

ISO

Tamoxifen results in increased expression of BNC2 mRNA

NCBI chr 5:103,724,934...104,061,890
Ensembl chr 5:103,724,934...104,125,428

G

BCL2 interacting protein 3

affects expression

ISO

Tamoxifen affects the expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

bolA family member 1

affects expression

ISO

Tamoxifen affects the expression of BOLA1 mRNA

NCBI chr 2:186,447,386...186,448,402
Ensembl chr 2:186,443,583...186,501,358

G

bolA family member 2

affects expression

ISO

Tamoxifen affects the expression of BOLA2 mRNA

NCBI chr 1:190,722,535...190,723,401
Ensembl chr 8:64,800,454...64,800,714
Ensembl chr 1:64,800,454...64,800,714

G

BOP1 ribosomal biogenesis factor

affects expression

ISO

Tamoxifen affects the expression of BOP1 mRNA

NCBI chr 7:110,052,716...110,076,529
Ensembl chr 7:110,052,720...110,076,529

G

BLOC-1 related complex subunit 5

affects expression

ISO

Tamoxifen affects the expression of BORCS5 mRNA

NCBI chr 4:169,190,025...169,272,335
Ensembl chr 4:169,204,528...169,271,819

G

B-Raf proto-oncogene, serine/threonine kinase

affects expression

ISO

Tamoxifen affects the expression of BRAF mRNA

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931

G

BRCA1 associated protein

affects expression

ISO

Tamoxifen affects the expression of BRAP mRNA

NCBI chr12:40,535,232...40,561,726
Ensembl chr12:40,535,232...40,561,726

G

BRCA1, DNA repair associated

affects activity
multiple interactions
increases response to substance

ISO

BRCA1 affects the activity of Tamoxifen
[Tamoxifen co-treated with BRCA1 protein mutant form] results in decreased expression of ESR1 protein
BRCA1 protein results in increased susceptibility to Tamoxifen
[Tamoxifen co-treated with Estradiol] results in increased expression of BRCA1 protein; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]; BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of CCND1 mRNA]; BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of MYC mRNA]; BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of PGR mRNA]; sodium arsenite inhibits the reaction [[Tamoxifen co-treated with Estradiol] results in increased expression of BRCA1 protein]

PMID:15750629 PMID:18997820 PMID:30664189

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BRCA1/BRCA2-containing complex subunit 3

affects expression

ISO

Tamoxifen affects the expression of BRCC3 mRNA

NCBI chr 9:2,073,927...2,076,469
Ensembl chr 9:2,073,184...2,084,185

G

BRMS1, transcriptional repressor and anoikis regulator

affects expression

ISO

Tamoxifen affects the expression of BRMS1 mRNA

NCBI chr 1:211,775,142...211,784,411
Ensembl chr 1:211,775,095...211,784,410

G

bromodomain and PHD finger containing, 1

increases expression

ISO

Tamoxifen results in increased expression of BRPF1 mRNA

NCBI chr 4:148,011,977...148,028,431
Ensembl chr 4:148,011,931...148,028,424

G

bone marrow stromal cell antigen 2

affects expression
increases expression

ISO

Tamoxifen affects the expression of BST2 mRNA
Tamoxifen results in increased expression of BST2 mRNA

PMID:19155303 PMID:20937368

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967

G

BTB domain containing 7

decreases expression

ISO

Tamoxifen results in decreased expression of BTBD7 mRNA

NCBI chr 6:127,685,185...127,774,947
Ensembl chr 6:127,688,421...127,737,222

G

basic transcription factor 3

affects expression

ISO

Tamoxifen affects the expression of BTF3 mRNA

NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125

G

BTG anti-proliferation factor 1

affects expression

ISO

Tamoxifen affects the expression of BTG1 mRNA

NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

ISO

Tamoxifen results in increased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

basic leucine zipper and W2 domains 1

affects expression

ISO

Tamoxifen affects the expression of BZW1 mRNA

NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684

G

complement C1q B chain

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of C1QB mRNA

NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840

G

C1q and TNF related 6

affects expression

ISO

Tamoxifen affects the expression of C1QTNF6 mRNA

NCBI chr 7:111,958,348...111,964,948
Ensembl chr 7:111,958,350...111,966,871

G

complement C1s

affects expression

ISO

Tamoxifen affects the expression of C1S mRNA

NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736

G

C2 calcium-dependent domain containing 2

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA
Tamoxifen affects the expression of C2CD2 mRNA

PMID:14699072 PMID:19059307

NCBI chr11:50,694,680...50,759,096
Ensembl chr11:50,694,563...50,759,016

G

complement C3

increases expression
affects expression

ISO
EXP

Tamoxifen results in increased expression of C3 mRNA; Tamoxifen results in increased expression of C3 protein
Tamoxifen affects the expression of C3 mRNA

PMID:11390168 PMID:12370124 PMID:17555576 PMID:19400957

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

similar to human chromosome 14 open reading frame 132

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA

NCBI chr 6:130,130,176...130,163,153
Ensembl chr 6:130,130,794...130,158,762

G

complement C8 alpha chain

increases expression

ISO

Tamoxifen results in increased expression of C8A mRNA

NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:124,812,131...124,866,710

G

carbonic anhydrase 12

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CA12 mRNA
Tamoxifen affects the expression of CA12 mRNA

PMID:14699072 PMID:19059307

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:76,169,815...76,225,465

G

carbonic anhydrase 3

affects expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of CAR3 mRNA
Tamoxifen results in decreased expression of CAR3 mRNA

PMID:17555576 PMID:19400957

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

carbonic anhydrase 4

affects expression

ISO

Tamoxifen affects the expression of CAR4 mRNA

NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916

G

calcineurin binding protein 1

affects expression

ISO

Tamoxifen affects the expression of CABIN1 mRNA

NCBI chr20:12,892,750...13,014,801
Ensembl chr20:12,892,771...13,014,800

G

calcium binding tyrosine phosphorylation regulated

increases expression

ISO

Tamoxifen results in increased expression of CABYR mRNA

NCBI chr18:4,166,790...4,178,570
Ensembl chr18:4,166,858...4,179,507

G

cache domain containing 1

affects expression

ISO

Tamoxifen affects the expression of CACHD1 mRNA

NCBI chr 5:120,527,224...120,752,685
Ensembl chr 5:120,526,770...120,772,877

G

calcium voltage-gated channel subunit alpha1 G

affects expression

ISO

Tamoxifen affects the expression of CACNA1G mRNA

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,851,896...79,919,634

G

calcium voltage-gated channel subunit alpha1 S

affects expression

ISO

Tamoxifen affects the expression of CACNA1S mRNA

NCBI chr13:50,045,668...50,115,903
Ensembl chr13:50,045,668...50,115,903

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

increases expression

ISO

Tamoxifen results in increased expression of CACNA2D1 mRNA

NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of CACNA2D3 mRNA

NCBI chr16:4,105,048...4,919,037
Ensembl chr16:4,105,048...4,919,098

G

calcium voltage-gated channel auxiliary subunit beta 3

affects expression

ISO

Tamoxifen affects the expression of CACNB3 mRNA

NCBI chr 7:131,663,810...131,676,085
Ensembl chr 7:131,662,545...131,676,085

G

calcium voltage-gated channel auxiliary subunit beta 4

affects expression

ISO

Tamoxifen affects the expression of CACNB4 mRNA

NCBI chr 3:57,315,900...57,578,271
Ensembl chr 3:57,315,900...57,578,220

G

calcyclin binding protein

affects expression

ISO

Tamoxifen affects the expression of CACYBP mRNA

NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505

G

calmodulin 1

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of CALM1 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA
Tamoxifen inhibits the reaction [CALM1 protein binds to NOS1 protein]

PMID:17098364 PMID:17555576 PMID:19059307

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calreticulin

decreases expression
affects expression

ISO

Tamoxifen results in decreased expression of CALR mRNA
Tamoxifen affects the expression of CALR mRNA

PMID:16202921 PMID:17555576

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

calreticulin 3

affects expression

ISO

Tamoxifen affects the expression of CALR3 mRNA

NCBI chr16:17,430,105...17,456,777
Ensembl chr16:17,430,153...17,457,198

G

calcium/calmodulin-dependent protein kinase ID

affects expression

ISO

Tamoxifen affects the expression of CAMK1D mRNA

PMID:17555576 PMID:20937368

NCBI chr17:77,491,191...77,892,018
Ensembl chr17:77,491,220...77,892,012

G

calcium/calmodulin-dependent protein kinase II beta

affects expression

ISO

Tamoxifen affects the expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

cyclase associated actin cytoskeleton regulatory protein 2

multiple interactions

ISO

ESR1 protein affects the reaction [Tamoxifen results in decreased expression of CAP2 mRNA]

NCBI chr17:18,260,462...18,409,681
Ensembl chr17:18,261,646...18,409,563

G

capping actin protein, gelsolin like

affects expression

ISO

Tamoxifen affects the expression of CAPG mRNA

NCBI chr 4:106,152,912...106,170,010
Ensembl chr 4:106,152,890...106,170,672

G

calpain 2

affects expression

ISO

Tamoxifen affects the expression of CAPN2 mRNA

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625

G

calpain 9

increases expression

ISO

Tamoxifen results in increased expression of CAPN9 mRNA

NCBI chr19:69,446,847...69,483,810
Ensembl chr19:69,446,847...69,483,810

G

calpain, small subunit 1

affects expression

ISO

Tamoxifen affects the expression of CAPNS1 mRNA

NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:94,572,083...94,583,368

G

cell cycle associated protein 1

affects expression

ISO

Tamoxifen affects the expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

capping actin protein of muscle Z-line subunit alpha 3

affects expression

ISO

Tamoxifen affects the expression of CAPZA3 mRNA

NCBI chr 4:174,660,446...174,661,659
Ensembl chr 4:174,659,693...174,665,846

G

carbonic anhydrase 2

affects expression
multiple interactions
increases expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of CAR2 mRNA
[ESR1 protein mutant form co-treated with Tamoxifen] results in increased expression of CAR2 mRNA; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of CAR2 mRNA]
Tamoxifen results in increased expression of CAR2 mRNA
Tamoxifen results in decreased expression of CAR2 mRNA

PMID:17555576 PMID:19400957 PMID:23213263

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase recruitment domain family, member 10

affects expression

ISO

Tamoxifen affects the expression of CARD10 mRNA

NCBI chr 7:112,210,944...112,252,044
Ensembl chr 7:112,210,776...112,239,806

G

calcium regulated heat stable protein 1

affects expression

ISO

Tamoxifen affects the expression of CARHSP1 mRNA

NCBI chr10:7,453,602...7,467,218
Ensembl chr10:7,452,978...7,467,770

G

coactivator-associated arginine methyltransferase 1

multiple interactions

ISO

[CARM1 protein binds to ESR1 protein] which affects the susceptibility to Tamoxifen; CARM1 protein promotes the reaction [Tamoxifen results in increased activity of ESR1 protein]

NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:28,373,362...28,418,056

G

capping protein regulator and myosin 1 linker 1

affects expression

ISO

Tamoxifen affects the expression of CARMIL1 mRNA

NCBI chr17:41,235,819...41,516,204
Ensembl chr17:41,236,229...41,516,221

G

cask-interacting protein 2

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA
Tamoxifen results in increased expression of CASKIN2 mRNA

PMID:19059307 PMID:25123088

NCBI chr10:101,526,131...101,540,362
Ensembl chr10:101,526,195...101,540,349

G

caspase 2

affects expression

ISO

Tamoxifen affects the expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

multiple interactions
increases activity
decreases activity
affects expression
increases expression

ISO
EXP

[Tamoxifen co-treated with Quercetin] affects the activity of CASP3 protein; AKT1 protein inhibits the reaction [Tamoxifen analog results in increased activity of CASP3 protein]; AKT1 protein inhibits the reaction [Tamoxifen results in increased activity of CASP3 protein]
Tamoxifen inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; zinc chloride inhibits the reaction [Tamoxifen results in increased activity of CASP3 protein]
Tamoxifen results in decreased activity of CASP3 protein
Tamoxifen analog results in increased activity of CASP3 protein; Tamoxifen results in increased activity of CASP3 protein
Tamoxifen affects the expression of CASP3 mRNA
Tamoxifen results in increased expression of CASP3 mRNA; Tamoxifen results in increased expression of CASP3 protein

PMID:12810152 PMID:14990993 PMID:15545282 PMID:16924424 PMID:17901229 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 6

affects expression

ISO

Tamoxifen affects the expression of CASP6 mRNA

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726

G

caspase 7

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of CASP7 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA; Tamoxifen promotes the reaction [methylselenic acid results in increased cleavage of CASP7 protein]

PMID:14699072 PMID:18790785 PMID:19059307

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions
increases expression

ISO

[[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 protein; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CASP8 protein modified form
Tamoxifen results in increased expression of CASP8 mRNA; Tamoxifen results in increased expression of CASP8 protein

PMID:17767197 PMID:18790785 PMID:20154269 PMID:38779996

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases cleavage
increases activity

ISO

[[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein; [Tamoxifen co-treated with Quercetin] affects the activity of CASP9 protein; [Tamoxifen co-treated with TNFSF10 protein] results in increased cleavage of CASP9 protein; AKT1 protein inhibits the reaction [Tamoxifen analog results in increased activity of CASP9 protein]; AKT1 protein inhibits the reaction [Tamoxifen results in increased activity of CASP9 protein]
Tamoxifen results in increased cleavage of CASP9 protein
Tamoxifen analog results in increased activity of CASP9 protein; Tamoxifen results in increased activity of CASP9 protein

PMID:14990993 PMID:17767197 PMID:18790785 PMID:32530119 PMID:38779996

Ensembl chr 5:159,391,188...159,409,648

G

catalase

increases expression
decreases activity
multiple interactions
decreases expression

EXP
ISO

Tamoxifen results in increased expression of CAT mRNA; Tamoxifen results in increased expression of CAT protein
Tamoxifen results in decreased activity of CAT protein
zinc chloride inhibits the reaction [Tamoxifen results in decreased activity of CAT protein]
Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of CAT protein]
Tamoxifen results in decreased expression of CAT protein

PMID:15696052 PMID:21966433 PMID:29183790 PMID:29974145 PMID:31532279 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of CAV1 mRNA
Tamoxifen results in increased expression of CAV1 protein

PMID:14699072 PMID:19288272

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

caveolae associated protein 3

affects expression

ISO

Tamoxifen affects the expression of CAVIN3 mRNA

NCBI chr 1:169,238,384...169,239,973
Ensembl chr 1:169,238,384...169,239,981

G

CBFA2/RUNX1 partner transcriptional co-repressor 3

affects expression

ISO

Tamoxifen affects the expression of CBFA2T3 mRNA

NCBI chr19:67,584,319...67,658,533
Ensembl chr19:67,589,258...67,658,136

G

Cbl proto-oncogene B

increases expression

ISO

Tamoxifen results in increased expression of CBLB mRNA

NCBI chr11:62,058,829...62,225,904
Ensembl chr11:62,061,653...62,225,778

G

chromobox 2

affects expression

ISO

Tamoxifen affects the expression of CBX2 mRNA

NCBI chr10:104,777,054...104,785,922
Ensembl chr10:104,777,056...104,785,926

G

chromobox 3

decreases expression

ISO

Tamoxifen results in decreased expression of CBX3 mRNA

NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:81,876,649...81,889,911

G

coiled-coil and C2 domain containing 1B

decreases expression

ISO

Tamoxifen results in decreased expression of CC2D1B mRNA

NCBI chr 5:128,581,962...128,596,045
Ensembl chr 5:128,581,994...128,596,022

G

coiled-coil domain containing 43

affects expression

ISO

Tamoxifen affects the expression of CCDC43 mRNA

NCBI chr10:88,150,672...88,162,863
Ensembl chr10:88,150,674...88,163,116

G

coiled-coil domain containing 50

affects expression

ISO

Tamoxifen affects the expression of CCDC50 mRNA

NCBI chr11:86,837,624...86,900,164
Ensembl chr11:86,837,624...86,899,980

G

coiled-coil domain containing 8

increases expression

ISO

Tamoxifen results in increased expression of CCDC8 mRNA

NCBI chr 1:86,807,607...86,810,935
Ensembl chr 1:86,806,942...86,814,204

G

coiled-coil domain containing 80

affects expression

ISO

Tamoxifen affects the expression of CCDC80 mRNA

NCBI chr11:69,191,188...69,224,844
Ensembl chr11:69,191,189...69,224,844

G

coiled-coil domain containing 86

affects expression

ISO

Tamoxifen affects the expression of CCDC86 mRNA

NCBI chr 1:217,015,059...217,021,439
Ensembl chr 1:217,014,848...217,021,468

G

coiled-coil domain containing 91

affects expression

ISO

Tamoxifen affects the expression of CCDC91 mRNA

NCBI chr 4:182,132,931...182,304,948
Ensembl chr 4:182,132,942...182,304,948

G

C-C motif chemokine ligand 11

affects expression

ISO

Tamoxifen affects the expression of CCL11 mRNA

NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575

G

C-C motif chemokine ligand 2

multiple interactions

ISO
EXP

[Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL2 mRNA
Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]
Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCL2 mRNA]; Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]

PMID:19059307 PMID:23038002 PMID:25305410

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL20 mRNA
Tamoxifen results in decreased expression of CCL20 mRNA

PMID:16298037 PMID:19059307

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

multiple interactions

ISO

[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 7

decreases expression

ISO

Tamoxifen results in decreased expression of CCL7 mRNA

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

cellular communication network factor 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of CCN1 mRNA
Tamoxifen results in increased expression of CCN1 mRNA

PMID:17555576 PMID:20937368 PMID:25123088

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

affects expression
increases expression

ISO

Tamoxifen affects the expression of CCN2 mRNA
Tamoxifen results in increased expression of CCN2 mRNA

PMID:20937368 PMID:25123088

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cellular communication network factor 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA

NCBI chr 7:87,983,788...87,990,810
Ensembl chr 7:87,982,216...87,994,581

G

cyclin A2

multiple interactions
increases expression

ISO

[Estradiol co-treated with Tamoxifen] results in decreased expression of CCNA2 mRNA
Tamoxifen results in increased expression of CCNA2 protein

PMID:15642790 PMID:19434490

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

increases expression

EXP

Tamoxifen results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

affects expression

ISO

Tamoxifen affects the expression of CCNB2 mRNA

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

affects expression
decreases expression
increases expression
multiple interactions
affects localization

ISO
EXP

Tamoxifen affects the expression of CCND1 mRNA
Tamoxifen results in decreased expression of CCND1 mRNA; Tamoxifen results in decreased expression of CCND1 protein
Tamoxifen results in increased expression of CCND1 mRNA
Tamoxifen results in increased expression of CCND1 protein
[Tamoxifen co-treated with Zearalenone] results in increased expression of CCND1 protein; Tamoxifen inhibits the reaction [Estradiol affects the expression of CCND1 mRNA]
Tamoxifen affects the localization of CCND1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNA; [Tamoxifen co-treated with tipifarnib] results in decreased expression of CCND1 protein; bisphenol A inhibits the reaction [Tamoxifen results in decreased expression of CCND1 mRNA]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]; BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of CCND1 mRNA]; CXCL12 protein promotes the reaction [Tamoxifen promotes the reaction [ESR2 protein binds to CCND1 promoter]]; Tamoxifen affects the reaction [Quercetin affects the expression of CCND1 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CCND1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CCND1 protein]; Tamoxifen inhibits the reaction [FGF2 protein results in increased expression of CCND1 protein]; Tamoxifen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Tamoxifen promotes the reaction [AG 1879 results in decreased expression of CCND1 protein]; Tamoxifen promotes the reaction [ESR2 protein binds to CCND1 promoter]; Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]

PMID:9094091 PMID:12602925 PMID:12841865 PMID:14699072 PMID:15489888 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

affects expression

ISO

Tamoxifen affects the expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin D3

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of CCND3 mRNA
Tamoxifen inhibits the reaction [Estradiol affects the expression of CCND3 mRNA]

PMID:9094091 PMID:17555576

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin D1 binding protein 1

affects expression

ISO

Tamoxifen affects the expression of CCNDBP1 mRNA

NCBI chr 3:128,416,105...128,427,985
Ensembl chr 3:128,416,054...128,436,008

G

cyclin E1

multiple interactions
decreases expression
increases expression
affects response to substance

ISO
EXP

[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] results in decreased activity of [CCNE1 protein binds to CDK2 protein]; [Tamoxifen co-treated with naringenin] results in decreased expression of CCNE1 mRNA; Tamoxifen affects the reaction [Quercetin affects the expression of CCNE1 mRNA]
Tamoxifen results in decreased expression of CCNE1 mRNA
Tamoxifen results in decreased expression of CCNE1 mRNA; Tamoxifen results in decreased expression of CCNE1 protein
Tamoxifen results in increased expression of CCNE1 protein
Tamoxifen results in increased expression of CCNE1 mRNA; Tamoxifen results in increased expression of CCNE1 protein
CCNE1 protein affects the susceptibility to Tamoxifen

PMID:12602925 PMID:12866041 PMID:15642790 PMID:19148479 PMID:20215421 More...

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin G1

affects expression

ISO

Tamoxifen affects the expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin L1

affects expression

ISO

Tamoxifen affects the expression of CCNL1 mRNA

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468

G

cell cycle progression 1

affects expression

ISO

Tamoxifen affects the expression of CCPG1 mRNA

NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:82,600,536...82,660,246

G

C-C motif chemokine receptor 2

decreases expression
multiple interactions

ISO

Tamoxifen results in decreased expression of CCR2 mRNA
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CCR2 mRNA

PMID:25123088 PMID:29974145

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059

G

C-C motif chemokine receptor 3

multiple interactions

ISO

[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CCR3 mRNA

NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593

G

chaperonin containing TCP1 subunit 2

affects expression

ISO

Tamoxifen affects the expression of CCT2 mRNA

NCBI chr 7:54,578,654...54,591,428
Ensembl chr 7:54,578,663...54,592,977

G

chaperonin containing TCP1 subunit 3

affects expression

ISO

Tamoxifen affects the expression of CCT3 mRNA

NCBI chr 2:176,063,529...176,088,180
Ensembl chr 2:176,063,526...176,089,925

G

chaperonin containing TCP1 subunit 5

affects expression

ISO

Tamoxifen affects the expression of CCT5 mRNA

NCBI chr 2:84,302,621...84,313,773
Ensembl chr 2:84,302,623...84,313,779

G

chaperonin containing TCP1 subunit 7

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of CCT7 mRNA
Tamoxifen results in increased expression of CCT7 mRNA

PMID:17555576 PMID:19400957

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

CD163 molecule

affects expression

ISO

Tamoxifen affects the expression of CD163 mRNA

NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146

G

CD24 molecule

increases expression

EXP
ISO

Tamoxifen results in increased expression of CD24A mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

CD302 molecule

affects expression

ISO

Tamoxifen affects the expression of CD302 mRNA

NCBI chr 3:65,131,017...65,164,737
Ensembl chr 3:65,113,102...65,164,737

G

CD320 molecule

affects expression

ISO

Tamoxifen affects the expression of CD320 mRNA

NCBI chr 7:15,328,320...15,334,138
Ensembl chr 7:15,311,286...15,334,138

G

CD36 molecule

increases expression
decreases expression
multiple interactions
affects expression

ISO

Tamoxifen results in increased expression of CD36 protein
Tamoxifen results in decreased expression of CD36 protein
PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; PPARG mRNA promotes the reaction [Tamoxifen results in decreased expression of CD36 mRNA]; PPARG mRNA promotes the reaction [Tamoxifen results in decreased expression of CD36 protein]; Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; Tamoxifen inhibits the reaction [fulvestrant results in increased expression of CD36 protein]
Tamoxifen results in decreased expression of CD36 mRNA; Tamoxifen results in decreased expression of CD36 protein
[Tamoxifen co-treated with Oleic Acid] results in increased expression of CD36 mRNA; Tamoxifen inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CD36 mRNA]; Tamoxifen inhibits the reaction [PPARG protein binds to CD36 promoter]; Tamoxifen inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; Tamoxifen inhibits the reaction [Rosiglitazone results in increased expression of CD36 mRNA]; Tamoxifen inhibits the reaction [Rosiglitazone results in increased expression of CD36 protein]; Tamoxifen inhibits the reaction [Troglitazone results in increased expression of CD36 protein]; Tamoxifen inhibits the reaction [U 0126 results in increased expression of CD36 mRNA]; Tamoxifen inhibits the reaction [U 0126 results in increased expression of CD36 protein]; U 0126 inhibits the reaction [Tamoxifen results in decreased expression of CD36 mRNA]; U 0126 inhibits the reaction [Tamoxifen results in decreased expression of CD36 protein]
Tamoxifen affects the expression of CD36 mRNA

PMID:9717954 PMID:17555576 PMID:27358406 PMID:38191086

NCBI chr 4:18,209,088...18,302,142

G

CD37 molecule

affects expression

ISO

Tamoxifen affects the expression of CD37 mRNA

NCBI chr 1:104,855,622...104,861,111
Ensembl chr 1:104,849,166...104,861,276

G

CD38 molecule

affects expression

ISO

Tamoxifen affects the expression of CD38 mRNA

NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505

G

CD3 delta subunit of T-cell receptor complex

affects expression

ISO

Tamoxifen affects the expression of CD3D mRNA

NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:54,175,155...54,196,722

G

CD44 molecule

affects expression

ISO

Tamoxifen affects the expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd48 molecule

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of CD48 mRNA

NCBI chr13:86,717,960...86,741,540
Ensembl chr13:86,717,961...86,742,942

G

CD52 molecule

affects expression

ISO

Tamoxifen affects the expression of CD52 mRNA

NCBI chr 5:151,603,537...151,605,096
Ensembl chr 5:151,603,524...151,605,086

G

Cd53 molecule

affects expression

ISO

Tamoxifen affects the expression of CD53 mRNA

NCBI chr 2:197,040,369...197,087,925
Ensembl chr 2:197,040,369...197,218,593

G

CD55 molecule (Cromer blood group)

affects expression

ISO

Tamoxifen affects the expression of CD55 mRNA

PMID:17555576 PMID:20937368

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

Cd5 molecule-like

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of CD5L mRNA

NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:175,088,884...175,099,926

G

Cd6 molecule

decreases expression

ISO

Tamoxifen results in decreased expression of CD6 mRNA

NCBI chr 1:216,867,767...216,906,642
Ensembl chr 1:216,867,771...216,879,432

G

Cd68 molecule

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of CD68 mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of CD68 mRNA

PMID:17555576 PMID:17630414

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

CD83 molecule

affects expression

ISO

Tamoxifen affects the expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

CD8 subunit beta

affects expression

ISO

Tamoxifen affects the expression of CD8B1 mRNA

PMID:17555576 PMID:20937368

NCBI chr 4:104,870,911...104,886,838
Ensembl chr 4:104,870,893...104,886,868

G

cytidine deaminase

affects expression
decreases expression

ISO

Tamoxifen affects the expression of CDA mRNA
Tamoxifen results in decreased expression of CDA mRNA

PMID:20937368 PMID:25123088

NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541

G

cell division cycle 20

affects expression

ISO

Tamoxifen affects the expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 25A

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA]

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle 25B

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25B protein]

NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:138,860,130...138,870,492

G

cell division cycle 26

affects expression

ISO

Tamoxifen affects the expression of CDC26 mRNA

NCBI chr 5:80,861,658...80,875,326
Ensembl chr 5:80,861,659...80,875,326

G

cell division cycle 34, ubiquitin conjugating enzyme

increases expression

ISO

Tamoxifen results in increased expression of CDC34 mRNA

NCBI chr 7:10,668,209...10,674,206
Ensembl chr 7:10,668,210...10,674,526

G

cell division cycle 37, HSP90 cochaperone

affects expression

ISO

Tamoxifen affects the expression of CDC37 mRNA

NCBI chr 8:27,954,292...27,966,935
Ensembl chr 8:27,948,016...27,983,931

G

cell division cycle 37-like 1

affects expression

ISO

Tamoxifen affects the expression of CDC37L1 mRNA

NCBI chr 1:236,118,630...236,147,527
Ensembl chr 1:236,118,555...236,207,079

G

cell division cycle 42

affects expression

ISO

Tamoxifen affects the expression of CDC42 mRNA

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627

G

cell division cycle 6

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of CDC6 mRNA
Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC6 mRNA]

PMID:17555576 PMID:24758408

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241

G

cell division cycle associated 4

affects expression

ISO

Tamoxifen affects the expression of CDCA4 mRNA

NCBI chr 6:137,713,390...137,722,652
Ensembl chr 6:137,713,051...137,722,580

G

cell division cycle associated 7

affects expression

ISO

Tamoxifen affects the expression of CDCA7 mRNA

NCBI chr 3:77,730,315...77,740,950
Ensembl chr 3:77,729,970...77,740,947

G

cell division cycle associated 7 like

increases expression

ISO

Tamoxifen results in increased expression of CDCA7L mRNA

NCBI chr 6:144,936,885...144,982,844
Ensembl chr 6:144,908,171...144,982,843

G

CUB domain containing protein 1

decreases expression

ISO

Tamoxifen results in decreased expression of CDCP1 mRNA

NCBI chr 8:131,706,140...131,742,799
Ensembl chr 8:131,706,140...131,742,877

G

cadherin 1

affects expression
multiple interactions
increases expression

ISO

Tamoxifen affects the expression of CDH1 mRNA
3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in increased expression of CDH1 protein]; Tamoxifen affects the reaction [Quercetin affects the expression of CDH1 mRNA]; Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in increased expression of CDH1 protein]
Tamoxifen results in increased expression of CDH1 mRNA; Tamoxifen results in increased expression of CDH1 protein

PMID:20937368 PMID:23921149 PMID:32530119 PMID:33024228

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 11

affects expression

ISO

Tamoxifen affects the expression of CDH11 mRNA

NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140

G

cadherin 19

decreases expression

ISO

Tamoxifen results in decreased expression of CDH19 mRNA

NCBI chr13:28,450,361...28,561,932
Ensembl chr13:28,451,283...28,533,753

G

cadherin 2

multiple interactions
decreases expression
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of CDH2 mRNA; Tamoxifen affects the reaction [Quercetin affects the expression of CDH2 mRNA]
Tamoxifen results in decreased expression of CDH2 mRNA
Tamoxifen affects the expression of CDH2 mRNA

PMID:14699072 PMID:19059307 PMID:32530119

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase 1

affects expression
decreases expression
increases expression

ISO
EXP

Tamoxifen affects the expression of CDK1 mRNA
Tamoxifen results in decreased expression of CDK1 mRNA
Tamoxifen results in increased expression of CDK1 mRNA

PMID:12841865 PMID:14699072 PMID:15604281 PMID:17555576 PMID:38779996

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 12

affects response to substance

ISO

CDK12 affects the susceptibility to Tamoxifen

NCBI chr10:83,697,174...83,793,676
Ensembl chr10:83,767,206...83,777,183
Ensembl chr10:83,767,206...83,777,183

G

cyclin-dependent kinase 18

affects expression

ISO

Tamoxifen affects the expression of CDK18 mRNA

NCBI chr13:46,107,763...46,140,705
Ensembl chr13:46,108,911...46,140,865

G

cyclin dependent kinase 2

multiple interactions
decreases expression
increases activity
decreases activity
increases expression

ISO

[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] results in decreased activity of [CCNE1 protein binds to CDK2 protein]; Tamoxifen promotes the reaction [CDK2 protein binds to CDKN1A protein]
Tamoxifen results in decreased expression of CDK2 mRNA
Tamoxifen results in increased activity of CDK2 protein
Tamoxifen results in decreased activity of CDK2 protein
Tamoxifen results in increased expression of CDK2 mRNA; Tamoxifen results in increased expression of CDK2 protein

PMID:12866041 PMID:15611077 PMID:15642790 PMID:20215421 PMID:34821461

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

decreases expression

ISO

Tamoxifen results in decreased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

CDK5 regulatory subunit associated protein 1

affects expression

ISO

Tamoxifen affects the expression of CDK5RAP1 mRNA

NCBI chr 3:163,189,435...163,333,003
Ensembl chr 3:163,191,056...163,332,908

G

cyclin-dependent kinase 6

affects expression

ISO

Tamoxifen affects the expression of CDK6 mRNA

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase-like 5

increases expression

ISO

Tamoxifen results in increased expression of CDKL5 mRNA

NCBI chr X:37,566,320...37,796,766
Ensembl chr X:37,566,378...37,796,760

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
affects expression

ISO

[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] results in increased expression of CDKN1A protein; [Tamoxifen co-treated with naringenin] results in increased expression of CDKN1A mRNA; Tamoxifen affects the reaction [Quercetin affects the expression of CDKN1A mRNA]; Tamoxifen inhibits the reaction [ESR1 protein binds to CDKN1A promoter]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of CDKN1A mRNA]; Tamoxifen promotes the reaction [CDK2 protein binds to CDKN1A protein]
Tamoxifen results in increased expression of CDKN1A mRNA
Tamoxifen affects the expression of CDKN1A mRNA
Tamoxifen results in increased expression of CDKN1A mRNA; Tamoxifen results in increased expression of CDKN1A protein

PMID:12866041 PMID:15611077 PMID:17555576 PMID:19434490 PMID:20549698 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases activity

ISO

[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with tipifarnib] results in increased expression of CDKN1B protein
Tamoxifen results in increased activity of CDKN1B protein

PMID:12866041 PMID:15665275 PMID:17876043

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cysteine dioxygenase type 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:41,619,070...41,633,891

G

cerebellar degeneration-related protein 2

affects expression

ISO

Tamoxifen affects the expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:184,934,129...184,968,863

G

carnitine deficiency-associated gene expressed in ventricle 3

affects expression

ISO

Tamoxifen affects the expression of CDV3 mRNA

NCBI chr 8:112,812,898...112,826,073
Ensembl chr 8:112,813,952...112,826,056

G

chromodomain Y-like

affects expression

ISO

Tamoxifen affects the expression of CDYL mRNA

NCBI chr17:29,188,697...29,409,805
Ensembl chr17:29,188,698...29,409,757

G

CCAAT/enhancer binding protein alpha

decreases expression

ISO

Tamoxifen results in decreased expression of CEBPA mRNA; Tamoxifen results in decreased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

affects expression
increases expression
multiple interactions

ISO

Tamoxifen affects the expression of CEBPB mRNA
Tamoxifen results in increased expression of CEBPB mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA

PMID:14699072 PMID:15604281 PMID:19059307 PMID:20937368 PMID:25123088

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CCAAT/enhancer binding protein delta

affects expression

ISO

Tamoxifen affects the expression of CEBPD mRNA

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824

G

CUGBP, Elav-like family member 2

affects expression

ISO

Tamoxifen affects the expression of CELF2 mRNA

NCBI chr17:75,813,928...76,639,300
Ensembl chr17:75,813,704...76,636,362

G

cell migration inducing hyaluronidase 2

affects expression

ISO

Tamoxifen affects the expression of CEMIP2 mRNA

NCBI chr 1:228,756,826...228,834,313
Ensembl chr 1:228,757,466...228,832,906

G

centromere protein A

affects expression

ISO

Tamoxifen affects the expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703

G

centromere protein E

affects expression

ISO

Tamoxifen affects the expression of CENPE mRNA

NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:226,300,798...226,369,636

G

centromere protein X

affects expression

ISO

Tamoxifen affects the expression of CENPX mRNA

NCBI chr10:106,489,796...106,492,637
Ensembl chr10:106,489,796...106,492,637

G

centrosomal protein 68

affects expression

ISO

Tamoxifen affects the expression of CEP68 mRNA

NCBI chr14:98,649,993...98,671,892
Ensembl chr14:98,649,993...98,671,868

G

centrosomal protein 83

affects expression

ISO

Tamoxifen affects the expression of CEP83 mRNA

NCBI chr 7:31,167,198...31,276,513
Ensembl chr 7:31,167,216...31,276,716

G

ceramide synthase 6

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA
Tamoxifen affects the expression of CERS6 mRNA

PMID:14699072 PMID:19059307

NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544

G

carboxylesterase 2H

multiple interactions
increases expression

EXP

[Tamoxifen co-treated with bexarotene] results in increased expression of CES2 mRNA
Tamoxifen results in increased expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

cilia and flagella associated protein 100

increases expression

ISO

Tamoxifen results in increased expression of CFAP100 mRNA

NCBI chr 4:124,471,913...124,495,990
Ensembl chr 4:124,472,023...124,495,799

G

complement factor B

affects expression

ISO

Tamoxifen affects the expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

complement factor D

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of CFD mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of CFD mRNA

PMID:17555576 PMID:17630414

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

craniofacial development protein 1

affects expression

ISO

Tamoxifen affects the expression of CFDP1 mRNA

NCBI chr19:56,627,596...56,733,099
Ensembl chr19:56,626,963...56,733,098

G

complement factor H

affects expression

ISO

Tamoxifen affects the expression of CFH mRNA

NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

ISO

[Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein modified form

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

CF transmembrane conductance regulator

affects expression

ISO

Tamoxifen affects the expression of CFTR mRNA

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

glycoprotein hormones, alpha polypeptide

decreases expression

ISO

Tamoxifen results in decreased expression of CGA mRNA

NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:54,235,019...54,295,464

G

cingulin

decreases expression

ISO

Tamoxifen results in decreased expression of CGN mRNA

NCBI chr 2:184,997,425...185,024,785
Ensembl chr 2:184,997,425...185,023,635

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

affects expression

ISO

Tamoxifen affects the expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

chondroadherin-like

increases expression

ISO

Tamoxifen results in increased expression of CHADL mRNA

NCBI chr 7:115,085,447...115,097,565
Ensembl chr 7:115,085,165...115,097,435

G

chromodomain helicase DNA binding protein 1-like

affects expression

ISO

Tamoxifen affects the expression of CHD1L mRNA

NCBI chr 2:187,819,869...187,906,359
Ensembl chr 2:187,811,954...187,890,477

G

checkpoint kinase 1

affects expression

ISO

Tamoxifen affects the expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

choline kinase alpha

affects expression

ISO

Tamoxifen affects the expression of CHKA mRNA

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752

G

charged multivesicular body protein 2A

affects expression

ISO

Tamoxifen affects the expression of CHMP2A mRNA

NCBI chr 1:82,731,212...82,735,088
Ensembl chr 1:82,732,231...82,738,613

G

cysteine and histidine rich domain containing 1

affects expression

ISO

Tamoxifen affects the expression of CHORDC1 mRNA

NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696

G

chordin

affects expression

ISO

Tamoxifen affects the expression of CHRD mRNA

NCBI chr11:93,676,400...93,685,584
Ensembl chr11:93,676,400...93,685,278

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

ISO

4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

ISO

Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

ISO

Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

ISO

4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248

G

carbohydrate sulfotransferase 10

affects expression

ISO

Tamoxifen affects the expression of CHST10 mRNA

NCBI chr 9:48,588,575...48,618,487
Ensembl chr 9:48,588,575...48,618,442

G

carbohydrate sulfotransferase 8

increases expression

ISO

Tamoxifen results in increased expression of CHST8 mRNA

NCBI chr 1:96,431,144...96,572,880
Ensembl chr 1:96,431,145...96,572,880

G

chromosome transmission fidelity factor 18

affects expression

ISO

Tamoxifen affects the expression of CHTF18 mRNA

NCBI chr10:15,247,525...15,255,573
Ensembl chr10:15,246,362...15,255,685

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Tamoxifen inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

calcium and integrin binding 1

affects expression

ISO

Tamoxifen affects the expression of CIB1 mRNA

NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:143,587,021...143,593,326

G

calcium and integrin binding family member 3

increases expression

ISO

Tamoxifen results in increased expression of CIB3 mRNA

NCBI chr16:17,656,453...17,665,848
Ensembl chr16:17,656,453...17,665,848

G

ciliary microtubule associated protein 1B

multiple interactions

EXP

[Bexarotene co-treated with Tamoxifen] results in increased expression of CIMAP1B mRNA

NCBI chr 7:122,323,860...122,326,921
Ensembl chr 7:122,323,860...122,326,876

G

cold inducible RNA binding protein

affects expression

ISO

Tamoxifen affects the expression of CIRBP mRNA

NCBI chr 7:10,184,515...10,189,623

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases response to substance
affects expression

ISO

CITED2 mRNA results in increased susceptibility to Tamoxifen
Tamoxifen affects the expression of CITED2 mRNA

PMID:19904269 PMID:20937368

NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782

G

creatine kinase B

increases expression
multiple interactions

EXP
ISO

Tamoxifen results in increased expression of CKB mRNA
Tamoxifen inhibits the reaction [Estradiol results in increased activity of CKB protein]

PMID:17029789 PMID:19400957

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, mitochondrial 1

affects expression

ISO

Tamoxifen affects the expression of CKMT1 mRNA

NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:128,783,597...128,789,483

G

CDC28 protein kinase regulatory subunit 1B

affects expression

ISO

Tamoxifen affects the expression of CKS1B mRNA

NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:177,130,777...177,135,365

G

CDC28 protein kinase regulatory subunit 2

affects expression

ISO

Tamoxifen affects the expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519

G

chloride channel accessory 1

affects expression

ISO

Tamoxifen affects the expression of CLCA1 mRNA

NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:236,599,022...236,624,714

G

chloride voltage-gated channel 4

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA
Tamoxifen affects the expression of CLCN4 mRNA

PMID:17555576 PMID:19059307

NCBI chr X:27,290,769...27,356,967
Ensembl chr X:27,290,868...27,356,939

G

claudin 1

affects expression

ISO

Tamoxifen affects the expression of CLDN1 mRNA

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

claudin 2

affects expression

ISO

Tamoxifen affects the expression of CLDN2 mRNA

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:108,237,676...108,262,377

G

claudin 3

affects expression

ISO

Tamoxifen affects the expression of CLDN3 mRNA

NCBI chr12:27,345,075...27,346,547
Ensembl chr12:27,345,076...27,348,841

G

claudin 4

affects response to substance

ISO

CLDN4 affects the susceptibility to Tamoxifen

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958

G

chloride intracellular channel 1

affects expression

ISO

Tamoxifen affects the expression of CLIC1 mRNA

NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367

G

clathrin interactor 1

affects expression

ISO

Tamoxifen affects the expression of CLINT1 mRNA

NCBI chr10:30,799,936...30,854,513
Ensembl chr10:30,799,971...30,854,508

G

CDC-like kinase 1

affects expression

ISO

Tamoxifen affects the expression of CLK1 mRNA

PMID:17555576 PMID:20937368

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

CDC-like kinase 4

affects expression

ISO

Tamoxifen affects the expression of CLK4 mRNA

NCBI chr10:36,024,364...36,042,366
Ensembl chr10:36,024,427...36,042,372

G

calmin

affects expression

ISO

Tamoxifen affects the expression of CLMN mRNA

NCBI chr 6:129,470,613...129,572,079
Ensembl chr 6:129,478,149...129,572,027

G

clock circadian regulator

affects expression

ISO

Tamoxifen affects the expression of CLOCK mRNA

NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872

G

cleavage factor polyribonucleotide kinase subunit 1

affects expression

ISO

Tamoxifen affects the expression of CLP1 mRNA

NCBI chr 3:90,213,461...90,217,165
Ensembl chr 3:90,213,465...90,217,538

G

clathrin, light chain B

affects expression

ISO

Tamoxifen affects the expression of CLTB mRNA

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915

G

clathrin heavy chain

affects expression

ISO

Tamoxifen affects the expression of CLTC mRNA

NCBI chr10:72,014,984...72,073,308
Ensembl chr10:72,014,986...72,070,691

G

clusterin

decreases expression

ISO

Tamoxifen results in decreased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cytidine/uridine monophosphate kinase 1

affects expression

ISO

Tamoxifen affects the expression of CMPK mRNA

NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:133,717,086...133,744,596

G

cytidine/uridine monophosphate kinase 2

affects expression
decreases expression

ISO

Tamoxifen affects the expression of CMPK2 mRNA
Tamoxifen results in decreased expression of CMPK2 mRNA

PMID:20937368 PMID:25123088

NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:48,802,321...48,813,652

G

CKLF-like MARVEL transmembrane domain containing 2B

affects expression

ISO

Tamoxifen affects the expression of CMTM2B mRNA

NCBI chr19:647,273...667,683
Ensembl chr19:647,273...658,277

G

calponin 1

affects expression

ISO

Tamoxifen affects the expression of CNN1 mRNA

NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:28,908,330...28,919,482

G

CCR4-NOT transcription complex, subunit 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to CNOT1 protein]

NCBI chr19:9,261,290...9,352,636
Ensembl chr19:9,261,294...9,352,636

G

CCR4-NOT transcription complex, subunit 4

increases expression
affects expression

ISO
EXP

Tamoxifen results in increased expression of CNOT4 mRNA
Tamoxifen affects the expression of CNOT4 mRNA

PMID:17555576 PMID:19400957

NCBI chr 4:64,679,903...64,781,432
Ensembl chr 4:64,679,904...64,738,083

G

cannabinoid receptor 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

cannabinoid receptor 2

multiple interactions

ISO

Tamoxifen inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]; Tamoxifen inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961

G

collagen type XI alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL11A1 mRNA

NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:204,509,136...204,702,264

G

collagen type XI alpha 2 chain

increases expression

ISO

Tamoxifen results in increased expression of COL11A2 mRNA

NCBI chr20:4,788,829...4,818,492
Ensembl chr20:4,788,829...4,817,648

G

collagen type XVI alpha 1 chain

increases expression

ISO

Tamoxifen results in increased expression of COL16A1 mRNA

NCBI chr 5:147,672,559...147,727,007
Ensembl chr 5:147,672,601...147,727,011

G

collagen type XVIII alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL18A1 mRNA

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collagen type I alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type XX alpha 1 chain

decreases expression

ISO

Tamoxifen results in decreased expression of COL20A1 mRNA

NCBI chr 3:188,477,663...188,512,326
Ensembl chr 3:188,465,648...188,511,078

G

collagen type XXIV alpha 1 chain

increases expression

ISO

Tamoxifen results in increased expression of COL24A1 mRNA

NCBI chr 2:236,872,583...237,129,768
Ensembl chr 2:236,872,265...237,129,447

G

collagen type XXVI alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL26A1 mRNA

NCBI chr12:25,429,362...25,575,205
Ensembl chr12:25,429,387...25,575,206

G

collagen type III alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL3A1 mRNA

PMID:14699072 PMID:20937368

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

collagen type IV alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

collagen type V alpha 1 chain

affects expression

ISO

Tamoxifen affects the expression of COL5A1 mRNA

NCBI chr 3:31,606,475...31,755,097
Ensembl chr 3:31,606,486...31,753,020

G

collagen type VI alpha 3 chain

affects expression

ISO

Tamoxifen affects the expression of COL6A3 mRNA

PMID:14699072 PMID:17555576

NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:98,809,171...98,886,990

G

COMM domain containing 3

affects expression

ISO

Tamoxifen affects the expression of COMMD3 mRNA

NCBI chr17:86,235,863...86,239,610
Ensembl chr17:86,235,863...86,239,610

G

catechol-O-methyltransferase

affects expression
multiple interactions
decreases expression
affects metabolic processing

ISO
EXP

Tamoxifen affects the expression of COMT mRNA
Tamoxifen affects the expression of COMT mRNA; Tamoxifen affects the expression of COMT protein
Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA]; Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein]
Tamoxifen results in decreased expression of COMT mRNA
COMT protein affects the metabolism of Tamoxifen

PMID:15288375 PMID:20937368 PMID:25123088 PMID:28463726

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COPI coat complex subunit epsilon

affects expression

ISO

Tamoxifen affects the expression of COPE mRNA

NCBI chr16:19,148,832...19,159,052
Ensembl chr16:19,148,832...19,159,212

G

coenzyme Q10B

increases expression

ISO

Tamoxifen results in increased expression of COQ10B mRNA

NCBI chr 9:64,048,168...64,068,082
Ensembl chr 9:64,048,103...64,068,322

G

coenzyme Q5, methyltransferase

affects expression

ISO

Tamoxifen affects the expression of COQ5 mRNA

NCBI chr12:46,977,632...46,994,575
Ensembl chr12:46,977,632...46,994,712

G

coenzyme Q8A

affects expression

ISO

Tamoxifen affects the expression of COQ8A mRNA

NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378

G

corin, serine peptidase

increases expression

ISO

Tamoxifen results in increased expression of CORIN mRNA

NCBI chr14:36,034,613...36,264,671
Ensembl chr14:36,034,993...36,264,649

G

coronin 1A

affects expression

ISO

Tamoxifen affects the expression of CORO1A mRNA

NCBI chr 1:190,726,129...190,731,133
Ensembl chr 1:190,726,130...190,731,102

G

coronin 2B

affects expression

ISO

Tamoxifen affects the expression of CORO2B mRNA

NCBI chr 8:71,802,329...71,912,739
Ensembl chr 8:71,802,329...71,912,739

G

cytochrome c oxidase subunit 5A

affects expression

ISO

Tamoxifen affects the expression of COX5A mRNA

NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279

G

cytochrome c oxidase subunit 5B

affects expression

ISO

Tamoxifen affects the expression of COX5B mRNA

NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:46,417,838...46,420,403

G

cytochrome c oxidase subunit 7A2

affects expression

ISO

Tamoxifen affects the expression of COX7A2 mRNA

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:55,514,261...55,514,512
Ensembl chr 8:55,514,261...55,514,512

G

cytochrome c oxidase subunit 7A2 like

affects expression

ISO

Tamoxifen affects the expression of COX7A2L mRNA

NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:16,936,795...16,950,798

G

cytochrome c oxidase subunit 7B

decreases expression

EXP
ISO

Tamoxifen results in decreased expression of COX7B mRNA

NCBI chr X:75,149,036...75,155,285
Ensembl chr X:75,148,996...75,155,284

G

carboxypeptidase A1

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of CPA1 mRNA

NCBI chr 4:60,224,801...60,230,928
Ensembl chr 4:60,224,801...60,230,928

G

carboxypeptidase A5

affects expression

ISO

Tamoxifen affects the expression of CPA5 mRNA

NCBI chr 4:60,197,123...60,216,883
Ensembl chr 4:60,197,152...60,216,875

G

carboxypeptidase E

affects expression

ISO

Tamoxifen affects the expression of CPE mRNA

PMID:14699072 PMID:17555576

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524

G

cytoplasmic polyadenylation element binding protein 2

increases expression

ISO

Tamoxifen results in increased expression of CPEB2 mRNA

NCBI chr14:71,999,958...72,056,012
Ensembl chr14:72,002,072...72,052,263

G

carboxypeptidase M

increases expression

ISO

Tamoxifen results in increased expression of CPM mRNA

NCBI chr 7:55,111,599...55,172,114
Ensembl chr 7:55,111,599...55,172,114

G

copine 2

increases expression

ISO

Tamoxifen results in increased expression of CPNE2 mRNA

NCBI chr19:10,440,245...10,477,783
Ensembl chr19:10,434,647...10,477,783

G

copine 8

affects expression

ISO

Tamoxifen affects the expression of CPNE8 mRNA

NCBI chr 7:123,494,864...123,669,060
Ensembl chr 7:123,494,865...123,669,060

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CPT1A mRNA]; Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 1B

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of CPT1B mRNA

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036

G

cAMP responsive element binding protein 3-like 2

affects expression

ISO

Tamoxifen affects the expression of CREB3L2 mRNA

NCBI chr 4:66,874,623...66,990,962
Ensembl chr 4:66,387,126...66,990,832

G

cAMP responsive element binding protein 3-like 4

increases expression

ISO

Tamoxifen results in increased expression of CREB3L4 mRNA

NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:177,987,981...177,993,485

G

CREB/ATF bZIP transcription factor

affects expression

ISO

Tamoxifen affects the expression of CREBZF mRNA

NCBI chr 1:153,829,544...153,836,073
Ensembl chr 1:153,829,448...153,845,122

G

cysteine-rich with EGF-like domains 1

affects expression

ISO

Tamoxifen affects the expression of CRELD1 mRNA

NCBI chr 4:148,187,510...148,197,120
Ensembl chr 4:148,187,265...148,197,116

G

cysteine-rich with EGF-like domains 2

affects expression

ISO

Tamoxifen affects the expression of CRELD2 mRNA

NCBI chr 7:121,788,754...121,796,230
Ensembl chr 7:121,788,745...121,796,228

G

corticotropin releasing hormone receptor 2

affects expression

ISO

Tamoxifen affects the expression of CRHR2 mRNA

NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:85,554,268...85,596,318

G

cysteine rich protein 1

affects expression

ISO

Tamoxifen affects the expression of CRIP1 mRNA

NCBI chr 6:138,047,801...138,055,672
Ensembl chr 6:138,047,801...138,055,672

G

cysteine-rich protein 2

increases expression

ISO

Tamoxifen results in increased expression of CRIP2 mRNA

NCBI chr 6:138,042,175...138,047,121
Ensembl chr 6:138,041,906...138,047,120

G

cysteine-rich secretory protein LCCL domain containing 2

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA
Tamoxifen affects the expression of CRISPLD2 mRNA

PMID:17555576 PMID:19059307

NCBI chr19:64,961,764...65,020,099
Ensembl chr19:64,961,771...65,020,349

G

cardiolipin synthase 1

affects expression

ISO

Tamoxifen affects the expression of CRLS1 mRNA

NCBI chr 3:140,572,680...140,591,543
Ensembl chr 3:140,572,716...140,591,599

G

crooked neck pre-mRNA splicing factor 1

affects expression

ISO

Tamoxifen affects the expression of CRNKL1 mRNA

NCBI chr 3:153,764,718...153,807,973
Ensembl chr 6:6,894,292...6,896,635
Ensembl chr 3:6,894,292...6,896,635

G

cryptochrome circadian regulator 1

affects expression

ISO

Tamoxifen affects the expression of CRY1 mRNA

NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822

G

crystallin, alpha B

affects expression

ISO

Tamoxifen affects the expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

crystallin, gamma S

increases expression

ISO

Tamoxifen results in increased expression of CRYGS mRNA

NCBI chr11:91,711,755...91,716,858
Ensembl chr11:91,711,755...91,716,858

G

crystallin, mu

decreases expression

ISO

Tamoxifen results in decreased expression of CRYM mRNA

NCBI chr 1:183,991,752...184,006,923
Ensembl chr 1:183,991,745...184,006,962

G

cysteine sulfinic acid decarboxylase

affects expression
increases expression

ISO

Tamoxifen affects the expression of CSAD mRNA
Tamoxifen results in increased expression of CSAD mRNA

PMID:20937368 PMID:25123088

NCBI chr 7:135,187,175...135,216,495
Ensembl chr 7:135,187,175...135,215,581

G

cold shock domain containing C2

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of CSDC2 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA

PMID:17555576 PMID:19059307

NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:115,332,128...115,346,596

G

chromosome segregation 1 like

affects expression

ISO

Tamoxifen affects the expression of CSE1L mRNA

NCBI chr 3:176,060,183...176,097,909
Ensembl chr 3:176,060,215...176,108,734

G

colony stimulating factor 1

increases expression

ISO

Tamoxifen results in increased expression of CSF1 mRNA

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

colony stimulating factor 1 receptor

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of CSF1R mRNA

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806

G

colony stimulating factor 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

decreases expression

ISO

Tamoxifen results in decreased expression of CSF3 mRNA

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

C-terminal Src kinase

affects expression

ISO

Tamoxifen affects the expression of CSK mRNA

NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274

G

casein kinase 2 alpha 1

affects expression

ISO

Tamoxifen affects the expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

chondroitin sulfate proteoglycan 4

increases expression

ISO

Tamoxifen results in increased expression of CSPG4 mRNA

NCBI chr 8:66,160,942...66,195,987
Ensembl chr 8:66,160,942...66,200,806

G

cystatin C

decreases expression

ISO
EXP

Tamoxifen results in decreased expression of CST3 mRNA

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

cystatin B

affects expression

ISO

Tamoxifen affects the expression of CSTB mRNA

PMID:14699072 PMID:17555576

NCBI chr20:10,245,157...10,247,199
Ensembl chr20:10,245,158...10,247,199

G

cleavage stimulation factor subunit 3

affects expression

ISO

Tamoxifen affects the expression of CSTF3 mRNA

NCBI chr 3:111,421,291...111,492,539
Ensembl chr 3:111,421,234...111,497,046

G

chitobiase

increases expression
affects expression

ISO

Tamoxifen results in increased expression of CTBS mRNA
Tamoxifen affects the expression of CTBS mRNA

PMID:15604281 PMID:17555576

NCBI chr 2:238,000,800...238,015,368
Ensembl chr 2:238,000,842...238,015,475

G

CTD small phosphatase like

affects expression

ISO

Tamoxifen affects the expression of CTDSPL mRNA

NCBI chr 8:127,520,478...127,644,999
Ensembl chr 8:127,520,499...127,644,999

G

catenin beta 1

multiple interactions
decreases expression

ISO

3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in decreased expression of CTNNB1 protein]; [Tamoxifen co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects the localization of CTNNB1 protein; Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in decreased expression of CTNNB1 protein]

PMID:22046442 PMID:23921149

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

CTP synthase 1

affects expression

ISO

Tamoxifen affects the expression of CTPS1 mRNA

NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:139,410,249...139,440,465

G

chymotrypsin-like

decreases expression

ISO

Tamoxifen results in decreased expression of CTRL mRNA

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979

G

cathepsin B

affects expression

ISO

Tamoxifen affects the expression of CTSB mRNA

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin C

affects expression
decreases expression

ISO

Tamoxifen affects the expression of CTSC mRNA
Tamoxifen results in decreased expression of CTSC mRNA

PMID:20937368 PMID:25123088

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082

G

cathepsin D

multiple interactions
increases expression

ISO

benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]
Tamoxifen results in increased expression of CTSD mRNA; Tamoxifen results in increased expression of CTSD protein

PMID:15149724 PMID:17157789

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin E

affects expression

ISO

Tamoxifen affects the expression of CTSE mRNA

NCBI chr13:45,644,168...45,666,722
Ensembl chr13:45,644,147...45,666,722

G

cathepsin F

affects expression

ISO

Tamoxifen affects the expression of CTSF mRNA

NCBI chr 1:211,582,169...211,587,917
Ensembl chr 1:211,582,098...211,587,916

G

cathepsin H

affects expression

ISO

Tamoxifen affects the expression of CTSH mRNA

NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181

G

cathepsin L

affects expression

ISO

Tamoxifen affects the expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

CUE domain containing 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA

NCBI chr10:73,389,798...73,484,914
Ensembl chr10:73,389,841...73,483,749

G

cullin 5

affects expression

ISO

Tamoxifen affects the expression of CUL5 mRNA

NCBI chr 8:62,909,150...62,974,641
Ensembl chr 8:62,912,193...62,965,463

G

cutC copper transporter

affects expression

ISO

Tamoxifen affects the expression of CUTC mRNA

NCBI chr 1:252,571,489...252,586,269
Ensembl chr 1:252,571,521...252,597,272

G

cut-like homeobox 1

decreases expression

ISO

Tamoxifen results in decreased expression of CUX1 mRNA

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:25,743,733...26,062,497

G

cut-like homeobox 2

increases expression
decreases expression

ISO

Tamoxifen results in increased expression of CUX2 mRNA
Tamoxifen results in decreased expression of CUX2 mRNA

PMID:17555576 PMID:25123088

NCBI chr12:40,168,402...40,368,303
Ensembl chr12:40,149,292...40,366,528

G

CWC15 spliceosome-associated protein

affects expression

ISO

Tamoxifen affects the expression of CWC15 mRNA

NCBI chr 8:19,586,900...19,597,817
Ensembl chr 2:77,747,121...77,747,856
Ensembl chr 8:77,747,121...77,747,856

G

CWF19 like cell cycle control factor 1

decreases expression

ISO

Tamoxifen results in decreased expression of CWF19L1 mRNA

NCBI chr 1:252,946,934...252,970,194
Ensembl chr 1:252,946,934...252,970,168

G

C-X3-C motif chemokine ligand 1

affects expression

ISO

Tamoxifen affects the expression of CX3CL1 mRNA

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

CXADR, Ig-like cell adhesion molecule

increases expression

ISO

Tamoxifen results in increased expression of CXADR mRNA; Tamoxifen results in increased expression of CXADR mRNA alternative form; Tamoxifen results in increased expression of CXADR protein; Tamoxifen results in increased expression of CXADR protein alternative form

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:30,469,526...30,516,988

G

C-X-C motif chemokine ligand 1

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

affects expression
decreases expression
multiple interactions

ISO

Tamoxifen affects the expression of CXCL10 mRNA
Tamoxifen results in decreased expression of CXCL10 mRNA
Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]

PMID:19533603 PMID:20937368 PMID:25123088

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 12

multiple interactions
decreases expression
decreases methylation
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA; [Tamoxifen co-treated with glyceollin] results in decreased expression of CXCL12 mRNA; CXCL12 protein promotes the reaction [Tamoxifen promotes the reaction [ESR2 protein binds to CCND1 promoter]]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CXCL12 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]
Tamoxifen results in decreased expression of CXCL12 mRNA
Tamoxifen results in decreased methylation of CXCL12 promoter
Tamoxifen results in increased expression of CXCL12 mRNA; Tamoxifen results in increased expression of CXCL12 protein

PMID:19059307 PMID:19584281 PMID:19748759 PMID:19797619 PMID:24758408 More...

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 2

multiple interactions

EXP

Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

affects expression

ISO

Tamoxifen affects the expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 1

multiple interactions

ISO

[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CXCR1 mRNA

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872

G

C-X-C motif chemokine receptor 4

multiple interactions
increases expression
increases methylation
decreases expression

ISO

DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 mRNA]; DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 protein]
tamoxifen inhibits the reaction [17beta-estradiol increases expression of CXCR4 protein in multiple cells]
Tamoxifen results in increased expression of CXCR4 mRNA
Tamoxifen results in increased methylation of CXCR4 promoter
Tamoxifen results in decreased expression of CXCR4 mRNA; Tamoxifen results in decreased expression of CXCR4 protein

CTD
RGD

PMID:19019622 PMID:25123088 PMID:28318328

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

CXXC finger protein 5

affects expression

ISO

Tamoxifen affects the expression of CXXC5 mRNA

NCBI chr18:27,701,650...27,732,633
Ensembl chr18:27,701,188...27,732,635

G

cytochrome b5 reductase 1

increases expression

ISO

Tamoxifen results in increased expression of CYB5R1 mRNA

NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465

G

cytochrome b5 reductase 3

decreases expression

ISO

Tamoxifen results in decreased expression of CYB5R3 mRNA

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome b-245 alpha chain

affects expression

ISO

Tamoxifen affects the expression of CYBA mRNA

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome c-1

affects expression

ISO

Tamoxifen affects the expression of CYC1 mRNA

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657

G

cytochrome c, somatic

multiple interactions
increases expression
affects expression
affects localization

ISO
EXP

[Tamoxifen co-treated with Quercetin] affects the expression of CYCS protein; Fulvestrant inhibits the reaction [Tamoxifen affects the localization of CYCS protein]
Tamoxifen results in increased expression of CYCS mRNA
Tamoxifen affects the expression of CYCS mRNA
Tamoxifen results in increased expression of CYCS mRNA; Tamoxifen results in increased expression of CYCS protein

PMID:16924424 PMID:17555576 PMID:19400957 PMID:20211987 PMID:32530119 More...

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cylicin 2

increases expression

ISO

Tamoxifen results in increased expression of CYLC2 mRNA

NCBI chr 5:70,349,791...70,384,673
Ensembl chr 5:70,349,791...70,364,840

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases response to substance
decreases expression
multiple interactions
affects expression

ISO
EXP

CYP17A1 gene polymorphism results in increased susceptibility to Tamoxifen
Tamoxifen results in decreased expression of CYP17A1 mRNA
[bexarotene co-treated with Tamoxifen] results in increased expression of CYP17A1 mRNA
Tamoxifen affects the expression of CYP17A1 mRNA

PMID:15706422 PMID:17630414 PMID:20937368 PMID:25123088

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
decreases expression
multiple interactions

ISO

Tamoxifen analog results in increased expression of CYP19A1 mRNA
Tamoxifen results in decreased expression of CYP19A1 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA; [Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]] which results in decreased chemical synthesis of aflatoxicol; Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]]; Tamoxifen inhibits the reaction [ESR1 protein binds to CYP19A1 promoter]

PMID:10704911 PMID:19059307 PMID:19549922 PMID:21296134 PMID:24994688

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases expression
decreases expression

ISO
EXP

Tamoxifen inhibits the reaction [Estradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Tamoxifen inhibits the reaction [Estradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]
Tamoxifen results in decreased activity of CYP1A1 protein
Tamoxifen metabolite results in increased expression of CYP1A1 mRNA
Tamoxifen inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]
Tamoxifen results in decreased expression of CYP1A1 mRNA

PMID:12628514 PMID:15157572 PMID:18420780 PMID:19224547 PMID:29285606 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases hydroxylation
increases activity
increases metabolic processing
multiple interactions
decreases activity

EXP
ISO

CYP1A2 protein results in increased hydroxylation of Tamoxifen
Tamoxifen metabolite results in increased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Tamoxifen
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; [CYP1A2 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene
Tamoxifen results in decreased activity of CYP1A2 protein

PMID:15587933 PMID:18420780 PMID:23397584 PMID:29285606

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
decreases activity

ISO

Tamoxifen results in increased expression of CYP1B1 protein
Tamoxifen results in decreased activity of CYP1B1 protein

PMID:12419016 PMID:18420780 PMID:19812351

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 26, subfamily a, polypeptide 1

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of CYP26A1 mRNA
[bexarotene co-treated with Tamoxifen] results in increased expression of CYP26A1 mRNA

PMID:14699072 PMID:17630414 PMID:20937368

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

cytochrome P450, family 26, subfamily b, polypeptide 1

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA
Tamoxifen results in decreased expression of CYP26B1 mRNA

PMID:19059307 PMID:25123088

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases expression

ISO

Tamoxifen results in decreased expression of CYP27B1 mRNA

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

cytochrome P450, family 2, subfamily a, polypeptide 1

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of CYP2A1 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases expression
decreases activity

ISO

Tamoxifen results in decreased expression of CYP2A4 mRNA
Tamoxifen results in decreased activity of CYP2A4 protein

PMID:18420780 PMID:25123088

NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

EXP

Tamoxifen analog results in increased expression of CYP2B2 mRNA; Tamoxifen results in increased expression of CYP2B2 mRNA

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions
affects expression
decreases activity
increases metabolic processing
increases activity

ISO

Tamoxifen results in increased expression of CYP2B6 protein
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CYP2B10 mRNA
Tamoxifen affects the expression of CYP2B10 mRNA
Tamoxifen results in decreased activity of CYP2B10 protein
Tamoxifen results in increased expression of CYP2B10 mRNA
CYP2B6 protein results in increased metabolism of Tamoxifen
Tamoxifen metabolite results in increased activity of CYP2B6 protein
[CYP2B6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene

PMID:7771797 PMID:18420780 PMID:19812351 PMID:20937368 PMID:29285606 More...

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

EXP

Tamoxifen promotes the reaction [testosterone enanthate results in increased expression of CYP2C11 protein]

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity
increases activity
increases metabolic processing
increases response to substance

ISO

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; [CYP2C19 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of CYP2C29 mRNA
Tamoxifen results in decreased activity of CYP2C29 protein
Tamoxifen metabolite results in increased activity of CYP2C19 protein
CYP2C19 gene polymorphism results in increased susceptibility to Tamoxifen

PMID:18420780 PMID:21047200 PMID:23397584 PMID:29285606 PMID:29974145

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity
increases activity

ISO

Tamoxifen results in decreased activity of CYP2C8 protein
Tamoxifen metabolite results in increased activity of CYP2C8 protein

PMID:15601807 PMID:29285606

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases activity
increases expression
increases response to substance
increases metabolic processing
decreases response to substance
affects metabolic processing
affects response to substance

ISO

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in decreased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of Tamoxifen metabolite; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of 4-hydroxy-N-desmethyltamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of N-desmethyltamoxifen; CYP2D6 gene affects the abundance of and affects the susceptibility to Tamoxifen
Tamoxifen results in decreased activity of CYP2D6 protein
Tamoxifen results in increased expression of CYP2D6 protein
CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifen; CYP2D6 protein results in increased susceptibility to Tamoxifen
CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifen
CYP2D6 protein affects the metabolism of Tamoxifen
CYP2D6 gene polymorphism affects the susceptibility to Tamoxifen; CYP2D6 polymorphism affects the susceptibility to Tamoxifen

PMID:15632378 PMID:15961252 PMID:18420780 PMID:19189210 PMID:19189212 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions
decreases expression

ISO

Tamoxifen results in decreased activity of CYP2E1 protein
Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 mRNA]; Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 protein]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
Tamoxifen results in decreased expression of CYP2E1 mRNA; Tamoxifen results in decreased expression of CYP2E1 protein

PMID:18420780 PMID:29974145

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

decreases expression

ISO

Tamoxifen results in decreased expression of CYP2F2 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 2, subfamily g, polypeptide 1

decreases expression

ISO

Tamoxifen results in decreased expression of CYP2G1 mRNA

NCBI chr 1:91,273,309...91,284,499
Ensembl chr 1:91,272,680...91,284,498

G

cytochrome P450, family 2, subfamily s, polypeptide 1

affects expression

ISO

Tamoxifen affects the expression of CYP2S1 mRNA

NCBI chr 1:90,437,741...90,453,073
Ensembl chr 1:90,438,224...90,453,073

G

cytochrome P450, family 2, subfamily t, polypeptide 1

multiple interactions
decreases expression

EXP

[Tamoxifen co-treated with bexarotene] results in decreased expression of CYP2T1 mRNA
Tamoxifen results in decreased expression of CYP2T1 mRNA

NCBI chr 1:91,573,923...91,579,215
Ensembl chr 1:91,574,572...91,579,215

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation
multiple interactions
increases response to substance
increases activity
decreases activity
increases expression
increases metabolic processing

EXP
ISO

CYP3A2 protein results in increased hydroxylation of Tamoxifen
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene; [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Tamoxifen; Tamoxifen inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein results in increased susceptibility to Tamoxifen
Tamoxifen metabolite results in increased activity of CYP3A4 protein; Tamoxifen results in increased activity of CYP3A4 protein
Tamoxifen results in decreased activity of CYP3A4 protein
Tamoxifen metabolite results in increased expression of CYP3A4 mRNA; Tamoxifen results in increased expression of CYP3A4 mRNA
[Bexarotene co-treated with Tamoxifen] results in increased expression of CYP3A11 mRNA; Tamoxifen promotes the reaction [testosterone enanthate results in increased expression of CYP3A2 protein]

PMID:8573203 PMID:12419016 PMID:14652237 PMID:15587933 PMID:17630414 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases hydroxylation
increases expression

EXP

CYP3A23-3A1 protein results in increased hydroxylation of Tamoxifen
Tamoxifen results in increased expression of CYP3A23-3A1 protein

PMID:10959800 PMID:15587933

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects metabolic processing
multiple interactions
increases metabolic processing
decreases expression
decreases activity

ISO

CYP3A5 protein affects the metabolism of Tamoxifen; CYP3A5 protein polymorphism affects the metabolism of Tamoxifen
[CYP3A5 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene
Tamoxifen results in decreased expression of CYP3A13 mRNA
Tamoxifen results in decreased activity of CYP3A5 protein

PMID:12419016 PMID:15596297 PMID:25123088 PMID:29285606

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 1

decreases expression

EXP

Tamoxifen results in decreased expression of CYP4A22 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily b, polypeptide 1

affects expression

ISO

Tamoxifen affects the expression of CYP4B1 mRNA

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

ISO

Tamoxifen results in decreased expression of CYP4F14 mRNA

NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612

G

cytochrome P450, family 51

affects expression

ISO

Tamoxifen affects the expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
affects expression

EXP
ISO

Tamoxifen results in decreased expression of CYP7A1 mRNA
Tamoxifen affects the expression of CYP7A1 mRNA

PMID:19224547 PMID:20937368

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 7 subfamily B member 1

affects expression

ISO

Tamoxifen affects the expression of CYP7B1 mRNA

NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions
decreases expression

EXP
ISO

[bexarotene co-treated with Tamoxifen] results in decreased expression of CYP8B1 mRNA
Tamoxifen results in decreased expression of CYP8B1 mRNA

PMID:17630414 PMID:25123088

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

cystin 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of CYS1 mRNA
Tamoxifen results in increased expression of CYS1 mRNA

PMID:20937368 PMID:25123088

NCBI chr 6:47,029,440...47,046,671
Ensembl chr 6:47,028,461...47,046,671

G

cysteinyl leukotriene receptor 2

affects expression

ISO

Tamoxifen affects the expression of CYSLTR2 mRNA

NCBI chr15:54,599,043...54,638,314
Ensembl chr15:54,598,818...54,713,597

G

DAB2 interacting protein

increases expression

ISO

Tamoxifen results in increased expression of DAB2IP mRNA

NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:39,312,745...39,483,730

G

dishevelled-binding antagonist of beta-catenin 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of DACT1 mRNA

NCBI chr 6:95,526,645...95,538,625
Ensembl chr 6:95,526,690...95,551,053

G

dishevelled-binding antagonist of beta-catenin 2

affects expression

ISO

Tamoxifen affects the expression of DACT2 mRNA

NCBI chr 1:63,854,182...63,864,153
Ensembl chr 1:63,854,182...63,864,255

G

dystroglycan 1

increases expression

ISO

Tamoxifen results in increased expression of DAG1 mRNA

NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:117,769,517...117,782,199

G

death-associated protein

affects expression

ISO

Tamoxifen affects the expression of DAP mRNA

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673

G

death-domain associated protein

affects expression

ISO

Tamoxifen affects the expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

DAZ associated protein 1

affects expression

ISO

Tamoxifen affects the expression of DAZAP1 mRNA

NCBI chr 7:10,074,342...10,098,810
Ensembl chr 7:10,074,849...10,095,599

G

DAZ associated protein 2

affects expression

ISO

Tamoxifen affects the expression of DAZAP2 mRNA

NCBI chr 7:133,593,503...133,599,044
Ensembl chr 7:133,593,512...133,599,047

G

dopamine beta-hydroxylase

decreases expression
multiple interactions

EXP

Tamoxifen results in decreased expression of DBH mRNA; Tamoxifen results in decreased expression of DBH protein
Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH protein]

NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316

G

D-box binding PAR bZIP transcription factor

affects expression

ISO

Tamoxifen affects the expression of DBP mRNA

NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205

G

discoidin, CUB and LCCL domain containing 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA

NCBI chr11:55,594,691...55,649,113
Ensembl chr11:55,594,691...55,649,085

G

deoxycytidine kinase

affects expression

ISO

Tamoxifen affects the expression of DCK mRNA

NCBI chr14:19,589,298...19,610,326
Ensembl chr14:19,589,298...19,610,326

G

decorin

decreases expression

ISO
EXP

Tamoxifen results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

dopachrome tautomerase

affects expression

ISO

Tamoxifen affects the expression of DCT mRNA

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029

G

dynactin subunit 2

affects expression

ISO

Tamoxifen affects the expression of DCTN2 mRNA

NCBI chr 7:64,977,338...64,992,875
Ensembl chr 7:64,977,363...64,992,873

G

DDAH family member 2, ADMA-independent

affects expression

ISO

Tamoxifen affects the expression of DDAH2 mRNA

NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183

G

dopa decarboxylase

affects expression

ISO

Tamoxifen affects the expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

DNA-damage inducible transcript 3

increases expression

ISO

Tamoxifen results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

affects expression

ISO

Tamoxifen affects the expression of DDIT4 mRNA

PMID:14699072 PMID:17555576 PMID:20937368

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

affects expression

ISO

Tamoxifen affects the expression of DDOST mRNA

NCBI chr 5:155,805,612...155,812,728
Ensembl chr 5:155,805,454...155,813,121

G

discoidin domain receptor tyrosine kinase 2

affects expression

ISO

Tamoxifen affects the expression of DDR2 mRNA

NCBI chr13:84,726,412...84,851,032
Ensembl chr13:84,731,180...84,850,288

G

DExD-box helicase 21

affects expression

ISO

Tamoxifen affects the expression of DDX21 mRNA

NCBI chr20:31,077,044...31,097,238
Ensembl chr20:31,077,045...31,097,238

G

DExD-box helicase 39A

affects expression

ISO

Tamoxifen affects the expression of DDX39A mRNA

NCBI chr19:41,323,465...41,331,413
Ensembl chr19:41,322,836...41,332,306

G

DEAD box helicase 3, Y-linked

affects expression

ISO

Tamoxifen affects the expression of DDX3Y mRNA

NCBI chr Y:1,190,042...1,210,699
Ensembl chr Y:1,191,242...1,210,650

G

DEAD-box helicase 4

decreases expression

ISO

Tamoxifen results in decreased expression of DDX4 mRNA

NCBI chr 2:45,961,174...46,016,097
Ensembl chr 2:45,961,174...46,015,951

G

DEAD-box helicase 42

increases expression

ISO

Tamoxifen results in increased expression of DDX42 mRNA

NCBI chr10:91,648,719...91,680,730
Ensembl chr10:91,648,248...91,680,729

G

DEAD-box helicase 47

affects expression

ISO

Tamoxifen affects the expression of DDX47 mRNA

NCBI chr 4:169,577,013...169,589,473
Ensembl chr 4:169,577,003...169,590,474

G

DExD-box helicase 50

affects expression

ISO

Tamoxifen affects the expression of DDX50 mRNA

NCBI chr20:31,104,354...31,133,652
Ensembl chr20:31,104,354...31,133,652

G

DEAD-box helicase 56

affects expression

ISO

Tamoxifen affects the expression of DDX56 mRNA

NCBI chr14:85,325,942...85,336,262
Ensembl chr14:85,325,942...85,336,262

G

DEXD/H-box helicase 60

affects expression

ISO

Tamoxifen affects the expression of DDX60 mRNA

NCBI chr16:33,087,940...33,208,843
Ensembl chr16:33,087,988...33,208,839

G

DEK proto-oncogene

decreases response to substance
decreases expression

ISO

DEK protein results in decreased susceptibility to Tamoxifen
Tamoxifen results in decreased expression of DEK mRNA; Tamoxifen results in decreased expression of DEK protein

NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122

G

DENN domain containing 2B

affects expression

ISO

Tamoxifen affects the expression of DENND2B mRNA

PMID:17555576 PMID:20937368

NCBI chr 1:172,978,895...173,129,623
Ensembl chr 1:172,978,895...173,129,810

G

DENN domain containing 2D

decreases expression

ISO

Tamoxifen results in decreased expression of DENND2D mRNA

NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:196,661,345...196,682,397

G

DEPP autophagy regulator 1

decreases expression
increases expression

ISO

Tamoxifen results in decreased expression of DEPP1 mRNA
Tamoxifen results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:16298037 PMID:17175557

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233

G

DEP domain containing MTOR-interacting protein

affects expression

ISO

Tamoxifen affects the expression of DEPTOR mRNA

NCBI chr 7:88,404,745...88,574,065
Ensembl chr 7:88,404,620...88,574,041

G

derlin 2

increases expression

ISO

Tamoxifen results in increased expression of DERL2 mRNA

NCBI chr10:56,226,340...56,238,038
Ensembl chr10:56,226,219...56,237,993

G

desumoylating isopeptidase 1

affects expression

ISO

Tamoxifen affects the expression of DESI1 mRNA

NCBI chr 7:115,401,613...115,422,974
Ensembl chr 7:115,401,624...115,423,172

G

diacylglycerol O-acyltransferase 2

decreases expression

ISO

Tamoxifen results in decreased expression of DGAT2 mRNA

NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566

G

dihydrofolate reductase

increases expression
affects expression

ISO

Tamoxifen results in increased expression of DHFR mRNA
Tamoxifen affects the expression of DHFR mRNA

PMID:15590111 PMID:17555576

NCBI chr 2:25,320,895...25,346,004

G

dehydrogenase/reductase 3

affects expression

ISO

Tamoxifen affects the expression of DHRS3 mRNA

NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:162,031,386...162,065,653

G

DEAH-box helicase 15

affects expression

ISO

Tamoxifen affects the expression of DHX15 mRNA

NCBI chr14:62,999,886...63,037,829
Ensembl chr14:62,999,877...63,037,828

G

DExH-box helicase 30

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of DHX30 mRNA
Tamoxifen inhibits the reaction [ESR1 protein binds to DHX30 protein]

PMID:17555576 PMID:23665804

NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:118,943,187...118,975,592

G

DEAH-box helicase 35

affects expression

ISO

Tamoxifen affects the expression of DHX35 mRNA

NCBI chr 3:167,869,971...167,927,300
Ensembl chr 3:167,870,055...167,927,300

G

DEAH-box helicase 38

decreases expression

ISO

Tamoxifen results in decreased expression of DHX38 mRNA

NCBI chr19:54,422,418...54,439,434
Ensembl chr19:54,422,418...54,439,423

G

DEAH-box helicase 40

affects expression

ISO

Tamoxifen affects the expression of DHX40 mRNA

NCBI chr10:72,081,867...72,118,792
Ensembl chr10:72,081,867...72,118,958

G

DEXH-box helicase 58

affects expression

ISO

Tamoxifen affects the expression of DHX58 mRNA

NCBI chr10:86,120,677...86,132,095
Ensembl chr10:86,120,677...86,131,844

G

diaphanous-related formin 3

affects expression

ISO

Tamoxifen affects the expression of DIAPH3 mRNA

NCBI chr15:68,951,992...69,421,623
Ensembl chr15:68,951,989...69,421,552

G

DIM1 rRNA methyltransferase and ribosome maturation factor

affects expression

ISO

Tamoxifen affects the expression of DIMT1 mRNA

NCBI chr 2:40,076,622...40,101,792
Ensembl chr 2:40,076,570...40,101,787

G

iodothyronine deiodinase 1

affects expression

ISO

Tamoxifen affects the expression of DIO1 mRNA

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

iodothyronine deiodinase 2

increases expression

ISO

Tamoxifen results in increased expression of DIO2 mRNA

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

dickkopf WNT signaling pathway inhibitor 4

decreases expression

ISO

Tamoxifen results in decreased expression of DKK4 mRNA

NCBI chr16:76,105,679...76,109,044
Ensembl chr16:76,105,679...76,109,044

G

dickkopf like acrosomal protein 1

affects expression

ISO

Tamoxifen affects the expression of DKKL1 mRNA

NCBI chr 1:104,830,462...104,835,711
Ensembl chr 1:104,829,478...104,835,711

G

dihydrolipoamide S-acetyltransferase

affects expression

ISO

Tamoxifen affects the expression of DLAT mRNA

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

DLG associated protein 4

affects expression

ISO

Tamoxifen affects the expression of DLGAP4 mRNA

NCBI chr 3:165,584,271...165,731,868
Ensembl chr 3:165,584,360...165,730,604

G

DLG associated protein 5

decreases expression

ISO

Tamoxifen results in decreased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

distal-less homeobox 5

affects expression

ISO

Tamoxifen affects the expression of DLX5 mRNA

NCBI chr 4:35,965,579...35,969,973
Ensembl chr 4:35,965,579...35,969,845

G

deleted in malignant brain tumors 1

increases expression

ISO
EXP

Tamoxifen results in increased expression of DMBT1 mRNA
Tamoxifen results in increased expression of DMBT1 mRNA; Tamoxifen results in increased expression of DMBT1 protein

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:195,047,713...195,126,704

G

DM1 protein kinase

increases expression

ISO

Tamoxifen results in increased expression of DMPK mRNA

NCBI chr 1:87,858,294...87,868,624
Ensembl chr 1:87,858,316...87,868,910

G

dematin actin binding protein

affects expression

ISO

Tamoxifen affects the expression of DMTN mRNA

NCBI chr15:52,087,667...52,111,956
Ensembl chr15:52,087,667...52,112,128

G

dynein, axonemal, heavy chain 11

decreases expression

ISO

Tamoxifen results in decreased expression of DNAH11 mRNA

NCBI chr 6:144,982,130...145,298,523
Ensembl chr 6:144,973,797...145,298,692

G

DnaJ heat shock protein family (Hsp40) member B1

affects expression

ISO

Tamoxifen affects the expression of DNAJB1 mRNA

PMID:17555576 PMID:20937368

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B11

affects expression

ISO

Tamoxifen affects the expression of DNAJB11 mRNA

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

DnaJ heat shock protein family (Hsp40) member B4

affects expression

ISO

Tamoxifen affects the expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B6

affects expression

ISO

Tamoxifen affects the expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

DnaJ heat shock protein family (Hsp40) member C12

affects expression

ISO

Tamoxifen affects the expression of DNAJC12 mRNA

NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251

G

DnaJ heat shock protein family (Hsp40) member C3

affects expression

ISO

Tamoxifen affects the expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

DnaJ heat shock protein family (Hsp40) member C4

affects expression

ISO

Tamoxifen affects the expression of DNAJC4 mRNA

NCBI chr 1:213,607,397...213,611,614
Ensembl chr 1:213,607,399...213,611,729

G

DnaJ heat shock protein family (Hsp40) member C5 beta

affects expression

ISO

Tamoxifen affects the expression of DNAJC5B mRNA

NCBI chr 2:103,889,863...103,982,413
Ensembl chr 2:103,889,919...103,982,423

G

deoxyribonuclease 1

affects expression

ISO

Tamoxifen affects the expression of DNASE1 mRNA

NCBI chr10:12,005,305...12,030,615
Ensembl chr10:12,005,306...12,010,497

G

dynamin 1-like

affects expression

ISO

Tamoxifen affects the expression of DNM1L mRNA

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

dynamin binding protein

affects expression

ISO

Tamoxifen affects the expression of DNMBP mRNA

NCBI chr 1:252,685,406...252,778,642
Ensembl chr 1:252,685,406...252,778,688

G

DNA methyltransferase 1

multiple interactions

ISO

[arsenic trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 mRNA; [arsenic trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

decreases expression

ISO

Tamoxifen results in decreased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

DNA methyltransferase 3 beta

multiple interactions
decreases expression
increases expression

ISO

DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 mRNA]; DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 protein]
Tamoxifen results in decreased expression of DNMT3B mRNA
Tamoxifen results in increased expression of DNMT3B mRNA alternative form; Tamoxifen results in increased expression of DNMT3B protein alternative form

PMID:19019622 PMID:25123088

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

DNA nucleotidylexotransferase

decreases expression

ISO

Tamoxifen results in decreased expression of DNTT mRNA

NCBI chr 1:249,805,802...249,837,685
Ensembl chr 1:249,805,802...249,837,684

G

dedicator of cytokinesis 9

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA

NCBI chr15:105,018,341...105,289,799
Ensembl chr15:105,024,912...105,289,799

G

docking protein 2

affects expression

ISO

Tamoxifen affects the expression of DOK2 mRNA

NCBI chr15:52,237,046...52,251,091
Ensembl chr15:52,236,900...52,251,074

G

docking protein 3

affects expression

ISO

Tamoxifen affects the expression of DOK3 mRNA

NCBI chr17:9,114,763...9,121,781
Ensembl chr17:9,114,762...9,120,335

G

dolichyldiphosphatase 1

affects expression

ISO

Tamoxifen affects the expression of DOLPP1 mRNA

NCBI chr 3:34,063,825...34,072,133
Ensembl chr 3:34,063,825...34,072,132

G

dolichyl-phosphate N-acetylglucosaminephosphotransferase 1

affects expression

ISO

Tamoxifen affects the expression of DPAGT1 mRNA

NCBI chr 8:53,560,869...53,567,625
Ensembl chr 8:53,555,239...53,567,898

G

double PHD fingers 1

affects expression
decreases expression

ISO

Tamoxifen affects the expression of DPF1 mRNA
Tamoxifen results in decreased expression of DPF1 mRNA

PMID:17555576 PMID:25123088

NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:93,726,970...93,743,425

G

dipeptidylpeptidase 4

affects expression

ISO

Tamoxifen affects the expression of DPP4 mRNA

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

dpy-19 like C-mannosyltransferase 3

increases expression

ISO

Tamoxifen results in increased expression of DPY19L3 mRNA

NCBI chr 1:97,487,206...97,554,232
Ensembl chr 1:97,487,206...97,554,232

G

dopamine receptor D5

affects expression
increases expression

ISO

Tamoxifen affects the expression of DRD5 mRNA
Tamoxifen results in increased expression of DRD5 mRNA

PMID:14699072 PMID:19429434

NCBI chr14:76,700,244...76,703,344
Ensembl chr14:76,700,241...76,703,466

G

developmentally regulated GTP binding protein 2

affects expression

ISO

Tamoxifen affects the expression of DRG2 mRNA

NCBI chr10:45,755,072...45,769,493
Ensembl chr10:45,755,059...45,769,523

G

desmocollin 2

affects expression

ISO

Tamoxifen affects the expression of DSC2 mRNA

NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,725,466...11,757,466

G

dystonin

affects expression
increases expression

ISO

Tamoxifen affects the expression of DST mRNA
Tamoxifen results in increased expression of DST mRNA

PMID:16202921 PMID:17555576

NCBI chr 9:43,631,716...44,025,535
Ensembl chr 9:43,631,517...44,025,533

G

dual serine/threonine and tyrosine protein kinase

increases expression

ISO

Tamoxifen results in increased expression of DSTYK mRNA

NCBI chr13:46,409,412...46,457,426
Ensembl chr13:46,409,412...46,457,424

G

dystrobrevin, beta

affects expression

ISO

Tamoxifen affects the expression of DTNB mRNA

NCBI chr 6:32,286,022...32,483,007
Ensembl chr 6:32,285,941...32,485,872

G

dystrobrevin binding protein 1

affects expression

ISO

Tamoxifen affects the expression of DTNBP1 mRNA

NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,891,337...19,984,418

G

deltex E3 ubiquitin ligase 1

affects expression

ISO

Tamoxifen affects the expression of DTX1 mRNA

NCBI chr12:41,510,252...41,541,433
Ensembl chr12:41,510,264...41,541,430

G

dihydrouridine synthase 2

affects expression

ISO

Tamoxifen affects the expression of DUS2 mRNA

NCBI chr19:50,816,306...50,864,559
Ensembl chr19:50,816,310...50,864,559

G

dihydrouridine synthase 3-like

decreases expression

ISO

Tamoxifen results in decreased expression of DUS3L mRNA

NCBI chr 9:1,680,619...1,685,784
Ensembl chr 9:1,675,819...1,686,367

G

dual specificity phosphatase 1

affects expression

ISO

Tamoxifen affects the expression of DUSP1 mRNA

PMID:14699072 PMID:20937368

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA

NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:135,009,590...135,011,809

G

dual specificity phosphatase 5

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of DUSP5 mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA

PMID:15604281 PMID:19059307

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 8

increases expression

ISO

Tamoxifen results in increased expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:206,598,942...206,612,441

G

dishevelled segment polarity protein 2

affects expression

ISO

Tamoxifen affects the expression of DVL2 mRNA

NCBI chr10:55,222,245...55,231,506
Ensembl chr10:55,222,056...55,231,506

G

dynein cytoplasmic 2 light intermediate chain 1

increases expression

ISO

Tamoxifen results in increased expression of DYNC2LI1 mRNA

NCBI chr 6:15,745,350...15,778,166
Ensembl chr 6:15,745,350...15,778,166

G

dynein light chain LC8-type 1

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of DYNLL1 mRNA
Tamoxifen results in increased expression of DYNLL1 mRNA

PMID:17555576 PMID:19400957

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

dynein light chain roadblock-type 2

affects expression

ISO

Tamoxifen affects the expression of DYNLRB2 mRNA

NCBI chr19:61,428,782...61,440,331
Ensembl chr19:61,429,065...61,441,071

G

E2F transcription factor 1

multiple interactions
decreases expression
increases expression

ISO
EXP

Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]; Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]
Tamoxifen results in decreased expression of E2F1 protein
[Tamoxifen results in increased expression of MIR17 mRNA] which results in decreased expression of E2F1 protein; [Tamoxifen results in increased expression of MIR92A1 mRNA] which results in decreased expression of E2F1 protein
Tamoxifen results in increased expression of E2F1 mRNA; Tamoxifen results in increased expression of E2F1 protein
Tamoxifen results in decreased expression of E2F1 mRNA

PMID:15590111 PMID:17343880 PMID:20215421

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 2

increases expression

ISO

Tamoxifen results in increased expression of E2F2 mRNA

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087

G

E2F transcription factor 3

decreases expression

ISO

Tamoxifen results in decreased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 6

affects expression

ISO

Tamoxifen affects the expression of E2F6 mRNA

NCBI chr 6:45,320,993...45,337,437
Ensembl chr 6:45,320,996...45,337,428

G

E2F transcription factor 8

affects expression

ISO

Tamoxifen affects the expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

E4F transcription factor 1

affects expression

ISO

Tamoxifen affects the expression of E4F1 mRNA

NCBI chr10:13,978,975...13,999,646
Ensembl chr10:13,978,990...13,990,506

G

Epstein-Barr virus induced 3

affects expression

ISO

Tamoxifen affects the expression of EBI3 mRNA

NCBI chr 9:861,441...874,731
Ensembl chr 9:870,792...874,973

G

EBP, cholestenol delta-isomerase

affects expression

ISO

Tamoxifen affects the expression of EBP mRNA

NCBI chr X:16,971,372...16,977,782
Ensembl chr X:16,971,405...16,977,781

G

endothelin converting enzyme 1

multiple interactions
increases expression

ISO

[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ECE1 mRNA]
Tamoxifen results in increased expression of ECE1 mRNA

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

endothelin-converting enzyme 2

affects expression

ISO

Tamoxifen affects the expression of ECE2 mRNA

NCBI chr11:93,767,559...93,782,896
Ensembl chr11:93,767,559...93,793,292

G

enoyl CoA hydratase domain containing 3

affects expression
decreases expression

ISO

Tamoxifen affects the expression of ECHDC3 mRNA
Tamoxifen results in decreased expression of ECHDC3 mRNA

PMID:17555576 PMID:25123088

NCBI chr17:76,980,112...77,002,934
Ensembl chr17:76,980,083...77,002,934

G

epithelial cell transforming 2

decreases expression

ISO

Tamoxifen results in decreased expression of ECT2 mRNA

NCBI chr 2:111,904,522...111,966,786
Ensembl chr 2:111,904,522...111,966,626

G

enhancer of mRNA decapping 3

affects expression

ISO

Tamoxifen affects the expression of EDC3 mRNA

NCBI chr 8:67,002,032...67,047,563
Ensembl chr 8:67,002,014...67,047,559

G

ER degradation enhancing alpha-mannosidase like protein 1

affects expression

ISO

Tamoxifen affects the expression of EDEM1 mRNA

NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060

G

EGF like repeats and discoidin domains 3

affects expression

ISO

Tamoxifen affects the expression of EDIL3 mRNA

NCBI chr 2:21,625,604...22,140,380
Ensembl chr 2:21,625,596...22,140,379

G

endothelin 1

multiple interactions
affects expression
increases expression

ISO

[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA; [ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA; Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]
Tamoxifen affects the expression of EDN1 mRNA
Tamoxifen results in increased expression of EDN1 mRNA

PMID:17555576 PMID:19943105

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

multiple interactions
increases expression

ISO

[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA; Tamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]
Tamoxifen results in increased expression of EDNRA mRNA

PMID:19059307 PMID:19943105

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

eukaryotic translation elongation factor 1 alpha 1

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of EEF1A1 protein
[Tretinoin co-treated with Tamoxifen] results in increased expression of EEF1A1 protein

NCBI chr 8:88,221,839...88,225,688
Ensembl chr 8:88,221,843...88,225,072

G

eukaryotic translation elongation factor 1 gamma

affects expression

ISO

Tamoxifen affects the expression of EEF1G mRNA

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

eukaryotic elongation factor-2 kinase

affects expression

ISO

Tamoxifen affects the expression of EEF2K mRNA

NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:184,824,420...184,888,048

G

estrogen-induced osteoclastogenesis regulator 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of EEIG1 mRNA]

NCBI chr 3:36,220,170...36,252,377
Ensembl chr 3:36,211,730...36,252,378

G

endonuclease/exonuclease/phosphatase family domain containing 1

affects expression

ISO

Tamoxifen affects the expression of EEPD1 mRNA

NCBI chr 8:32,233,834...32,340,148
Ensembl chr 8:32,233,070...32,340,147

G

EGF containing fibulin extracellular matrix protein 1

affects expression

ISO

Tamoxifen affects the expression of EFEMP1 mRNA

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808

G

EGF containing fibulin extracellular matrix protein 2

affects expression

ISO

Tamoxifen affects the expression of EFEMP2 mRNA

NCBI chr 1:212,211,057...212,218,739
Ensembl chr 1:212,210,972...212,218,739

G

EF-hand domain family, member D1

affects expression

ISO

Tamoxifen affects the expression of EFHD1 mRNA

NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798

G

ephrin A1

affects expression

ISO

Tamoxifen affects the expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

ephrin B3

affects expression

ISO

Tamoxifen affects the expression of EFNB3 mRNA

NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,773,282...54,797,651

G

EFR3 homolog B

increases expression

ISO

Tamoxifen results in increased expression of EFR3B mRNA

NCBI chr 6:32,664,593...32,740,417
Ensembl chr 6:32,666,945...32,740,417

G

elongation factor Tu GTP binding domain containing 2

affects expression

ISO

Tamoxifen affects the expression of EFTUD2 mRNA

NCBI chr10:88,304,992...88,352,229
Ensembl chr10:88,304,992...88,346,299

G

epidermal growth factor

increases response to substance
affects activity
multiple interactions

ISO

EGF protein results in increased susceptibility to Tamoxifen
Tamoxifen affects the activity of EGF protein
[EGF protein results in increased activity of EGFR protein] which results in decreased susceptibility to Tamoxifen; EGFR mutant form inhibits the reaction [[EGF protein results in increased activity of EGFR protein] which results in decreased susceptibility to Tamoxifen]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CCND1 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CXCL12 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of GFRA2 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MCM4 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MCM7 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of SGK1 mRNA]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of TGFA mRNA]; Tamoxifen inhibits the reaction [EGF protein results in increased expression of FCMR mRNA]; Tamoxifen inhibits the reaction [EGF protein results in increased expression of GADD45A mRNA]; Tamoxifen inhibits the reaction [EGF protein results in increased expression of HBEGF mRNA]; Tamoxifen inhibits the reaction [EGF protein results in increased expression of IL20 mRNA]; Tamoxifen inhibits the reaction [EGF protein results in increased expression of RELB mRNA]

PMID:14649542 PMID:19395996 PMID:24758408

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

decreases response to substance
affects expression
increases expression
multiple interactions

ISO

EGFR protein results in decreased susceptibility to Tamoxifen
Tamoxifen affects the expression of EGFR mRNA
Tamoxifen results in increased expression of EGFR mRNA; Tamoxifen results in increased expression of EGFR protein
[EGF protein results in increased activity of EGFR protein] which results in decreased susceptibility to Tamoxifen; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR protein; [Tamoxifen co-treated with ESR2 protein] results in increased expression of EGFR mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of EGFR protein; EGFR mutant form inhibits the reaction [[EGF protein results in increased activity of EGFR protein] which results in decreased susceptibility to Tamoxifen]

PMID:15665275 PMID:16000581 PMID:17555576 PMID:19347870 PMID:20005069 More...

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions
affects expression

ISO
EXP

[Tamoxifen co-treated with ESR2 protein] results in increased expression of EGR1 mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of EGR1 mRNA
Tamoxifen affects the expression of EGR1 mRNA

PMID:17630414 PMID:19059307 PMID:20937368

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

EH-domain containing 3

affects expression

ISO

Tamoxifen affects the expression of EHD3 mRNA

NCBI chr 6:27,392,709...27,417,445
Ensembl chr 6:27,392,709...27,417,445

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression
decreases expression
increases expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of EHHADH mRNA
Tamoxifen results in decreased expression of EHHADH mRNA
Tamoxifen results in increased expression of EHHADH mRNA
[Tamoxifen co-treated with bexarotene] results in increased expression of EHHADH mRNA

PMID:17630414 PMID:20937368 PMID:25123088 PMID:27089845

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

EI24, autophagy associated transmembrane protein

affects expression

ISO

Tamoxifen affects the expression of EI24 mRNA

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:44,683,144...44,695,214

G

eukaryotic translation initiation factor 1

multiple interactions
increases expression

ISO
EXP

[Tamoxifen co-treated with ESR1 protein] results in increased expression of EIF1 mRNA
Tamoxifen results in increased expression of EIF1 mRNA

PMID:19059307 PMID:19400957

NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654

G

eukaryotic translation initiation factor 1A

affects expression

ISO

Tamoxifen affects the expression of EIF1A mRNA; Tamoxifen affects the expression of EIF1AY mRNA

NCBI chr18:41,512,298...41,524,645
Ensembl chr18:41,503,180...41,549,696

G

eukaryotic translation initiation factor 1B

affects expression

ISO

Tamoxifen affects the expression of EIF1B mRNA

NCBI chr 8:129,080,497...129,083,772
Ensembl chr 8:129,078,293...129,083,772
Ensembl chr 5:129,078,293...129,083,772

G

eukaryotic translation initiation factor 2-alpha kinase 2

affects expression

ISO

Tamoxifen affects the expression of EIF2AK2 mRNA

NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116

G

eukaryotic translation initiation factor 2 subunit alpha

affects expression

ISO

Tamoxifen affects the expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 2 subunit beta

increases expression

ISO
EXP

Tamoxifen results in increased expression of EIF2S2 mRNA

NCBI chr 3:163,834,846...163,855,733
Ensembl chr 3:163,834,851...163,855,570

G

eukaryotic translation initiation factor 3, subunit D

affects expression

ISO

Tamoxifen affects the expression of EIF3D mRNA

NCBI chr 7:111,420,351...111,432,761
Ensembl chr 7:111,420,351...111,432,740

G

eukaryotic translation initiation factor 3, subunit F

affects expression

ISO

Tamoxifen affects the expression of EIF3F mRNA

NCBI chr 1:172,369,062...172,378,043
Ensembl chr 1:172,369,062...172,378,041

G

eukaryotic translation initiation factor 3, subunit G

affects expression

ISO

Tamoxifen affects the expression of EIF3G mRNA

NCBI chr 8:27,705,914...27,709,946
Ensembl chr 8:27,705,915...27,709,987

G

eukaryotic translation initiation factor 3, subunit I

affects expression

ISO

Tamoxifen affects the expression of EIF3I mRNA

NCBI chr 5:147,219,457...147,226,910
Ensembl chr 5:147,219,366...147,241,232

G

eukaryotic translation initiation factor 3, subunit K

affects expression

ISO

Tamoxifen affects the expression of EIF3K mRNA

NCBI chr 1:93,387,628...93,397,551
Ensembl chr 1:93,387,628...93,397,802

G

eukaryotic translation initiation factor 4A3

affects expression

ISO

Tamoxifen affects the expression of EIF4A3 mRNA

NCBI chr10:105,047,567...105,057,561
Ensembl chr10:105,047,568...105,058,207

G

eukaryotic translation initiation factor 4E

affects expression

ISO

Tamoxifen affects the expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 5

increases expression
affects expression

ISO

Tamoxifen results in increased expression of EIF5 mRNA
Tamoxifen affects the expression of EIF5 mRNA

PMID:15604281 PMID:17555576

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

eukaryotic translation initiation factor 6

affects expression

ISO

Tamoxifen affects the expression of EIF6 mRNA

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

ELAV like RNA binding protein 1

affects expression

ISO

Tamoxifen affects the expression of ELAVL1 mRNA

NCBI chr12:7,441,699...7,482,625
Ensembl chr12:7,441,699...7,482,631

G

E74 like ETS transcription factor 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA

NCBI chr13:49,242,265...49,247,102
Ensembl chr13:49,242,267...49,247,380

G

engulfment and cell motility 3

affects expression

ISO

Tamoxifen affects the expression of ELMO3 mRNA

NCBI chr19:50,091,883...50,096,324
Ensembl chr19:50,091,924...50,096,338

G

ELOVL fatty acid elongase 1

decreases expression

ISO

Tamoxifen results in decreased expression of ELOVL1 mRNA

NCBI chr 5:137,246,781...137,251,351
Ensembl chr 5:137,246,849...137,251,352

G

ELOVL fatty acid elongase 3

affects expression

ISO

Tamoxifen affects the expression of ELOVL3 mRNA

NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559

G

ELOVL fatty acid elongase 6

multiple interactions
affects expression

EXP
ISO

[bexarotene co-treated with Tamoxifen] results in increased expression of ELOVL6 mRNA
Tamoxifen affects the expression of ELOVL6 mRNA

PMID:17630414 PMID:20937368

NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:220,738,064...220,845,549

G

ER membrane protein complex subunit 2

affects expression

ISO

Tamoxifen affects the expression of EMC2 mRNA

NCBI chr 7:76,471,899...76,508,866
Ensembl chr 7:76,471,899...76,510,178

G

ER membrane protein complex subunit 3

affects expression

ISO

Tamoxifen affects the expression of EMC3 mRNA

NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:148,217,395...148,234,595

G

ER membrane protein complex subunit 6

affects expression

ISO

Tamoxifen affects the expression of EMC6 mRNA

NCBI chr10:58,292,584...58,293,850
Ensembl chr10:58,292,470...58,298,885

G

epithelial membrane protein 1

affects expression

ISO

Tamoxifen affects the expression of EMP1 mRNA

NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365

G

epithelial membrane protein 2

affects expression

ISO

Tamoxifen affects the expression of EMP2 mRNA

NCBI chr10:5,866,869...5,901,533
Ensembl chr10:5,866,922...5,901,532

G

ectodermal-neural cortex 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ENC1 mRNA
Tamoxifen affects the expression of ENC1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

endonuclease domain containing 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA

NCBI chr 8:19,490,615...19,520,007
Ensembl chr 8:19,490,615...19,520,007

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions
increases expression
affects expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA
Tamoxifen results in increased expression of ENPP2 mRNA
Tamoxifen affects the expression of ENPP2 mRNA

PMID:17555576 PMID:19059307 PMID:25123088

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleotide pyrophosphatase/phosphodiesterase 6

affects expression

ISO

Tamoxifen affects the expression of ENPP6 mRNA

NCBI chr16:51,898,557...52,026,789
Ensembl chr16:51,898,557...52,026,728

G

endosome associated trafficking regulator 1

affects expression

ISO

Tamoxifen affects the expression of ENTR1 mRNA

NCBI chr 3:29,599,059...29,605,780
Ensembl chr 3:29,599,059...29,605,898

G

endosomal transmembrane epsin interactor 1

increases expression

ISO

Tamoxifen results in increased expression of ENTREP1 mRNA

NCBI chr 1:231,018,987...231,073,474
Ensembl chr 1:231,018,987...231,102,708

G

E1A binding protein p300

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to EP300 protein]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

E1A binding protein p400

decreases expression

ISO

Tamoxifen results in decreased expression of EP400 mRNA

NCBI chr12:51,551,665...51,658,635
Ensembl chr12:51,551,695...51,658,634

G

erythrocyte membrane protein band 4.1-like 2

affects expression

ISO

Tamoxifen affects the expression of EPB41L2 mRNA

NCBI chr 1:21,682,336...21,857,106
Ensembl chr 1:21,682,335...21,857,105

G

erythrocyte membrane protein band 4.1 like 4A

affects expression

ISO

Tamoxifen affects the expression of EPB41L4A mRNA

NCBI chr18:25,680,169...25,890,998
Ensembl chr18:25,680,171...25,888,498

G

ependymin related 1

increases expression

ISO

Tamoxifen results in increased expression of EPDR1 mRNA

NCBI chr17:50,029,591...50,054,254
Ensembl chr17:50,029,256...50,054,250

G

epoxide hydrolase 1

affects expression

ISO

Tamoxifen affects the expression of EPHX1 mRNA

PMID:14699072 PMID:17555576

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

epsin 2

increases expression

ISO

Tamoxifen results in increased expression of EPN2 mRNA

NCBI chr10:46,697,238...46,759,128
Ensembl chr10:46,697,238...46,759,092

G

erythropoietin receptor

affects response to substance

ISO

EPOR protein affects the susceptibility to Tamoxifen

NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:28,765,746...28,770,322

G

epiplakin 1

decreases expression

ISO

Tamoxifen results in decreased expression of EPPK1 mRNA

NCBI chr 7:109,697,607...109,718,468
Ensembl chr 7:109,697,607...109,718,468

G

EPS8 signaling adaptor L2

affects expression

ISO

Tamoxifen affects the expression of EPS8L2 mRNA

NCBI chr 1:205,875,825...205,901,109
Ensembl chr 1:205,875,801...205,901,101

G

epithelial stromal interaction 1

affects expression

ISO

Tamoxifen affects the expression of EPSTI1 mRNA

NCBI chr15:59,692,712...59,791,376
Ensembl chr15:59,693,142...59,791,380

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases response to substance
increases phosphorylation
increases expression

ISO

[ERBB2 protein results in increased activity of ESR1 protein] which results in decreased susceptibility to Tamoxifen; ERBB2 protein inhibits the reaction [PA2G4 protein results in increased susceptibility to Tamoxifen]
ERBB2 protein results in decreased susceptibility to Tamoxifen
Tamoxifen results in increased phosphorylation of ERBB2 protein
Tamoxifen results in increased expression of ERBB2 protein

PMID:15665275 PMID:16000581 PMID:16023854 PMID:17157789 PMID:19075277 More...

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

erb-b2 receptor tyrosine kinase 3

decreases response to substance
affects expression

ISO

ERBB3 protein results in decreased susceptibility to Tamoxifen
Tamoxifen affects the expression of ERBB3 mRNA

PMID:16000581 PMID:17555576

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

ERCC excision repair 2, TFIIH core complex helicase subunit

increases response to substance

ISO

ERCC2 gene SNP results in increased susceptibility to Tamoxifen

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102

G

endoplasmic reticulum-golgi intermediate compartment 1

affects expression

ISO

Tamoxifen affects the expression of ERGIC1 mRNA

NCBI chr10:17,035,615...17,131,411
Ensembl chr10:17,035,615...17,131,376

G

ERGIC and golgi 3

affects expression

ISO

Tamoxifen affects the expression of ERGIC3 mRNA

NCBI chr 3:164,985,108...164,994,897
Ensembl chr 3:164,984,853...164,994,897

G

ERH, mRNA splicing and mitosis factor

affects expression

ISO

Tamoxifen affects the expression of ERH mRNA

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623

G

endothelial cell-specific molecule 1

increases expression

ISO

Tamoxifen results in increased expression of ESM1 mRNA

NCBI chr 2:46,609,253...46,617,991
Ensembl chr 2:46,609,204...46,617,990

G

estrogen receptor 1

affects response to substance
increases activity
affects binding
decreases activity
increases expression
multiple interactions
affects expression
increases phosphorylation
increases stability
decreases expression
affects methylation
affects activity
decreases response to substance
increases response to substance

ISO
EXP

ESR1 mRNA alternative form affects the susceptibility to Tamoxifen; ESR1 protein affects the susceptibility to Tamoxifen
Tamoxifen results in increased activity of ESR1 protein
Tamoxifen binds to ESR1 protein
Tamoxifen results in decreased activity of ESR1 protein
Tamoxifen results in increased expression of ESR1 protein
Tamoxifen binds to ESR1 protein; Tamoxifen metabolite binds to ESR1 protein
Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]
Tamoxifen results in increased expression of ESR1 mRNA
Tamoxifen affects the expression of ESR1 mRNA
[arsenic trioxide co-treated with Tamoxifen] results in decreased methylation of ESR1 gene; [arsenic trioxide co-treated with Tamoxifen] results in increased expression of ESR1 mRNA; [arsenic trioxide co-treated with Tamoxifen] results in increased expression of ESR1 protein; [ESR1 protein mutant form co-treated with Tamoxifen] results in increased expression of CAR2 mRNA; [sodium arsenite co-treated with Tamoxifen] results in increased expression of ESR1 protein; [Tamoxifen co-treated with BRCA1 protein mutant form] results in decreased expression of ESR1 protein; ESR1 protein affects the reaction [Tamoxifen results in increased expression of MMD2 mRNA]; ESR1 protein mutant form inhibits the reaction [Tamoxifen results in decreased expression of AQP1 mRNA]; ESR1 protein mutant form inhibits the reaction [Tamoxifen results in decreased expression of SLC9A3 mRNA]; Tamoxifen binds to and results in increased activity of ESR1 protein mutant form; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP1 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of AQP9 protein]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of CAR2 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of SLC9A3 mRNA]; Tamoxifen inhibits the reaction [ESR1 protein mutant form results in decreased expression of SLC9A3 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]; Tamoxifen promotes the reaction [Estradiol results in increased expression of ESR1 protein]; Tamoxifen promotes the reaction [Linseed Oil results in decreased expression of ESR1 protein]
Tamoxifen results in increased phosphorylation of ESR1 protein
Tamoxifen results in increased stability of ESR1 protein
Tamoxifen results in increased expression of ESR1 mRNA; Tamoxifen results in increased expression of ESR1 protein
Tamoxifen results in decreased expression of ESR1 mRNA; Tamoxifen results in decreased expression of ESR1 mRNA alternative form; Tamoxifen results in decreased expression of ESR1 protein; Tamoxifen results in decreased expression of ESR1 protein alternative form
Tamoxifen affects the methylation of ESR1 promoter
Tamoxifen affects the activity of ESR1 protein
ESR1 gene polymorphism results in decreased susceptibility to Tamoxifen; ESR1 protein results in decreased susceptibility to Tamoxifen
ESR1 protein alternative form results in increased susceptibility to Tamoxifen; ESR1 protein results in increased susceptibility to Tamoxifen
4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [CARM1 protein binds to ESR1 protein] which affects the susceptibility to Tamoxifen; [ERBB2 protein results in increased activity of ESR1 protein] which results in decreased susceptibility to Tamoxifen; [Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifen; [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein; [Tamoxifen binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of EGFR protein; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of LINC00312 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of PLAU mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of SLN mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA; [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of BSP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of EIF1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of G0S2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of GRK5 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of IDH2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of ISG20 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of LPL mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of MSMB mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of PTPRE mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RET mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of SGK1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of SYBU mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of TIPARP mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA; [Tamoxifen co-treated with Estradiol] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; [Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein]; bisphenol A inhibits the reaction [Tamoxifen results in decreased expression of ESR1 mRNA]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]; CARM1 protein promotes the reaction [Tamoxifen results in increased activity of ESR1 protein]; ESR1 protein affects the reaction [GATA3 protein affects the susceptibility to Tamoxifen]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of CAP2 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of F2R mRNA]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of LGR5 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in decreased expression of NEK7 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of FLOT1 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of FOXO1 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of G0S2 mRNA]; ESR1 protein affects the reaction [Tamoxifen results in increased expression of KLRC3 mRNA]; ESR1 protein inhibits the reaction [Tamoxifen results in decreased expression of FOXM1 mRNA]; ESR1 protein promotes the reaction [Tamoxifen results in decreased expression of FOXM1 protein]; ESR1 protein promotes the reaction [Tamoxifen results in increased abundance of Lipids]; Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of ESR1 protein]]; FKBPL protein inhibits the reaction [Tamoxifen results in increased phosphorylation of ESR1 protein]; FOXA1 protein affects the reaction [Tamoxifen affects the activity of ESR1 protein]; FOXL2 protein inhibits the reaction [[Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA]; FOXM1 protein affects the reaction [ESR1 protein results in increased susceptibility to Tamoxifen]; HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]; methoxyacetic acid promotes the reaction [Tamoxifen results in increased activity of ESR1 protein]; NCOR2 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]; Paclitaxel inhibits the reaction [Tamoxifen binds to ESR1 protein]; Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]]; Tamoxifen affects the reaction [Quercetin affects the expression of ESR1 mRNA alternative form]; Tamoxifen analog binds to and results in decreased activity of ESR1 protein; Tamoxifen binds to and affects the activity of ESR1 protein; Tamoxifen binds to and results in decreased activity of ESR1 protein; Tamoxifen binds to and results in increased activity of ESR1 protein; Tamoxifen inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Tamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [[ESR1 protein binds to NCOR1 protein] which binds to TFF1 promoter]; Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [bisphenol A results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Chlorpyrifos results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Coumestrol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-pentyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dibutyl Phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]]; Tamoxifen inhibits the reaction [Diethylhexyl Phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [diisobutyl phthalate binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to CDKN1A promoter]; Tamoxifen inhibits the reaction [ESR1 protein binds to CNOT1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to CYP19A1 promoter]; Tamoxifen inhibits the reaction [ESR1 protein binds to DHX30 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to EP300 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to ILK protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to MGMT protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA2 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA6 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR2 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NELFB protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NFKBIB protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B2 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NRIP1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to PELP1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to PRAME protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to TRRAP protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to TXNRD1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to AICDA promoter]]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to ESR1 protein]]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Tamoxifen inhibits the reaction [Estrogens results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [MEN1 protein binds to ESR1 protein]; Tamoxifen inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [phthalic acid metabolite binds to and results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]; Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA]; Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]; Tamoxifen promotes the reaction [[ESR1 protein binds to AGR2 promoter] which results in increased expression of AGR2 mRNA]; Tamoxifen promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]; Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]; Tamoxifen promotes the reaction [bisphenol A results in increased activity of ESR1 protein mutant form]; Tamoxifen promotes the reaction [Coumestrol results in increased activity of ESR1 protein mutant form]; Tamoxifen promotes the reaction [ESR1 protein binds to AGR2 promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to ESR1 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to ESR2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to FOXL2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to KLRC3 gene]; Tamoxifen promotes the reaction [ESR1 protein binds to MMP1 promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to PGR promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]; Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]; Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [Estradiol results in increased activity of ESR1 protein mutant form]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein modified form]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein]; Tamoxifen promotes the reaction [Quercetin results in decreased expression of ESR1 mRNA]; Tamoxifen promotes the reaction [SP1 protein binds to ESR1 protein]; Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein; TP53 protein inhibits the reaction [Tamoxifen results in increased expression of ESR1 protein]

PMID:9048584 PMID:11162928 PMID:11174852 PMID:11518614 PMID:11748029 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
affects binding
increases response to substance
increases expression
decreases expression
decreases response to substance
affects response to substance

ISO
EXP

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CA12 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FADD mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FLNB mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FST mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HK1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of IVL mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KAZN mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LBH mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAFF mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAGEA8 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MN1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PCTP mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGES mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RET mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RHOF mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SALL1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SCNN1A mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SEMA3F mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SERPINB6 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SSH1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of STK24 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SYBU mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SYNPO mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TACC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TACC2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TGFA mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TOB1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of WNT5A mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ZCCHC24 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ZNF395 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of AREG mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ATF3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL20 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of CDH2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of CDO1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of CXCL8 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of DACT1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of EGFR mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of EGFR protein; [Tamoxifen co-treated with ESR2 protein] results in increased expression of EGR1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ENC1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of FUT9 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of GAD1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of GRB10 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of GYG1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of HBEGF mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of ID4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of INHBA mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of JAG1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of KRT17 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of KRT34 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of NAB1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of OCLN mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of PDP1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of PTX3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RFK mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RGS4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RRAD mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of SLCO4C1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of SOD2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TCIM mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TGFBI mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TMEM158 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNC mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNFRSF11B mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNIK mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TRAF5 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; CXCL12 protein promotes the reaction [Tamoxifen promotes the reaction [ESR2 protein binds to CCND1 promoter]]; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of F13A1 mRNA]; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of IVL mRNA]; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of KLRC3 mRNA]; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of MAFF mRNA]; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of PTPRH mRNA]; ESR2 protein affects the reaction [Tamoxifen results in increased expression of NNMT mRNA]; ESR2 protein affects the reaction [Tamoxifen results in increased expression of PTPRO mRNA]; ESR2 protein promotes the reaction [Tamoxifen results in increased expression of BIK protein]; Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR2 mRNA]]; Tamoxifen binds to and results in decreased activity of ESR2 protein; Tamoxifen binds to and results in increased activity of ESR2 protein; Tamoxifen inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]; Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR2 mRNA]; Tamoxifen promotes the reaction [ESR1 protein binds to ESR2 protein]; Tamoxifen promotes the reaction [ESR2 protein binds to [[FOS protein binds to JUN protein] which binds to PTPRO promoter]]; Tamoxifen promotes the reaction [ESR2 protein binds to CCND1 promoter]; Tamoxifen promotes the reaction [ESR2 protein binds to ESR2 protein]; Tamoxifen promotes the reaction [Quercetin results in decreased expression of ESR2 mRNA]
Tamoxifen binds to Esr2 protein
Tamoxifen binds to ESR2 protein
ESR2 protein results in increased susceptibility to Tamoxifen
Tamoxifen results in increased expression of ESR2 mRNA
[Estradiol co-treated with Tamoxifen] results in increased expression of ESR2 protein; Tamoxifen inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Tamoxifen inhibits the reaction [ESR2 protein binds to H19 gene]; Tamoxifen inhibits the reaction [ESR2 protein binds to NCOA1 protein]; Tamoxifen inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
Tamoxifen results in increased expression of ESR2 protein
Tamoxifen results in decreased expression of ESR2 mRNA
Linseed Oil inhibits the reaction [Tamoxifen results in decreased expression of ESR2 mRNA]
Tamoxifen results in decreased expression of ESR2 mRNA; Tamoxifen results in decreased expression of ESR2 protein
Tamoxifen binds to ESR2 protein; Tamoxifen metabolite binds to ESR2 protein
ESR2 protein results in decreased susceptibility to Tamoxifen
ESR2 protein affects the susceptibility to Tamoxifen

CTD
RGD

PMID:8650195 PMID:9048584 PMID:9492041 PMID:11518614 PMID:12224631 More...

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

estrogen related receptor, alpha

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; AG 1879 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; bisphenol A inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; GPER1 protein promotes the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; Pertussis Toxin inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; Tamoxifen promotes the reaction [SP1 protein binds to ESRRA promoter]; Tamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter]
Tamoxifen results in increased expression of ESRRA mRNA; Tamoxifen results in increased expression of ESRRA protein

PMID:20211987 PMID:30467747

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

estrogen-related receptor gamma

multiple interactions
decreases expression
affects binding

ISO

bisphenol A inhibits the reaction [Tamoxifen results in decreased expression of ESRRG mRNA]; Tamoxifen binds to and affects the activity of ESRRG protein; Tamoxifen inhibits the reaction [PPARGC1A protein binds to ESRRG protein]
Tamoxifen binds to ESRRG protein

PMID:11447273 PMID:16889744 PMID:30467747

NCBI chr13:101,699,043...102,316,877
Ensembl chr13:101,889,706...102,316,877

G

electron transfer flavoprotein regulatory factor 1

affects expression

ISO

Tamoxifen affects the expression of ETFRF1 mRNA

NCBI chr 4:179,910,651...179,916,095
Ensembl chr 4:179,910,914...179,916,095

G

ethanolamine kinase 2

increases expression

ISO

Tamoxifen results in increased expression of ETNK2 mRNA

NCBI chr13:47,362,964...47,381,100
Ensembl chr13:47,363,060...47,381,100

G

ETS proto-oncogene 2, transcription factor

affects expression

ISO

Tamoxifen affects the expression of ETS2 mRNA

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:48,491,394...48,507,842

G

ETS variant transcription factor 4

affects expression

ISO

Tamoxifen affects the expression of ETV4 mRNA

NCBI chr10:87,206,977...87,222,202
Ensembl chr10:87,206,977...87,222,318

G

ecotropic viral integration site 2A

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA
Tamoxifen affects the expression of EVI2A mRNA

PMID:19059307 PMID:20937368

NCBI chr10:64,983,727...64,987,627
Ensembl chr10:64,983,705...64,999,516

G

exosome component 10

affects expression

ISO

Tamoxifen affects the expression of EXOSC10 mRNA

NCBI chr 5:164,278,414...164,302,067
Ensembl chr 5:164,278,440...164,302,067

G

exosome component 5

affects expression

ISO

Tamoxifen affects the expression of EXOSC5 mRNA

NCBI chr 1:90,295,495...90,305,047
Ensembl chr 1:90,293,797...90,305,046

G

exostosin glycosyltransferase 2

affects expression

ISO

Tamoxifen affects the expression of EXT2 mRNA

NCBI chr 3:100,120,776...100,253,424
Ensembl chr 3:100,120,776...100,253,596

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

ISO

[EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifen

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

coagulation factor XIII A1 chain

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of F13A1 mRNA
ESR2 protein affects the reaction [Tamoxifen results in decreased expression of F13A1 mRNA]

NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948

G

coagulation factor II, thrombin

affects expression

ISO

Tamoxifen affects the expression of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

coagulation factor II (thrombin) receptor

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Tamoxifen results in decreased expression of F2R mRNA]
Tamoxifen affects the expression of F2R mRNA

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579

G

coagulation factor III, tissue factor

affects expression

ISO

Tamoxifen affects the expression of F3 mRNA

PMID:14699072 PMID:20937368

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

coagulation factor VII

affects expression

ISO

Tamoxifen affects the expression of F7 mRNA

NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738

G

coagulation factor VIII

affects expression
increases expression

ISO

Tamoxifen affects the expression of F8 mRNA
Tamoxifen results in increased expression of F8 protein

PMID:15850603 PMID:17555576

NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683

G

coagulation factor IX

increases expression

ISO

Tamoxifen results in increased expression of F9 protein

NCBI chr X:143,388,642...143,433,143
Ensembl chr X:143,388,621...143,433,146

G

fatty acid binding protein 1

decreases expression
increases expression

EXP
ISO

Tamoxifen results in decreased expression of FABP1 mRNA
Tamoxifen results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17567588 PMID:19224547

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

fatty acid binding protein 2

multiple interactions
decreases expression

EXP

[Tamoxifen co-treated with bexarotene] results in decreased expression of FABP2 mRNA
Tamoxifen results in decreased expression of FABP2 mRNA

NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686

G

fatty acid binding protein 3

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of FABP3 mRNA
[bexarotene co-treated with Tamoxifen] results in increased expression of FABP3 mRNA

PMID:17555576 PMID:17630414

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

fatty acid binding protein 4

decreases expression

ISO

Tamoxifen results in decreased expression of FABP4 protein

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fatty acid binding protein 7

affects expression

ISO

Tamoxifen affects the expression of FABP7 mRNA

NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,669,601...37,675,907

G

Fas associated via death domain

multiple interactions
increases phosphorylation

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FADD mRNA
Tamoxifen results in increased phosphorylation of FADD protein

PMID:16450001 PMID:19059307

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

fatty acid desaturase 1

affects expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of FADS1 mRNA
Tamoxifen results in decreased expression of FADS1 mRNA

PMID:17555576 PMID:25123088 PMID:28138993

NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615

G

fatty acid desaturase 2

decreases expression
multiple interactions

EXP
ISO

Tamoxifen results in decreased expression of FADS2 mRNA
[Tamoxifen co-treated with bexarotene] results in increased expression of FADS2 mRNA

PMID:17630414 PMID:25123088 PMID:28138993

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

fumarylacetoacetate hydrolase domain containing 1

affects expression

ISO

Tamoxifen affects the expression of FAHD1 mRNA

NCBI chr10:14,378,058...14,379,497
Ensembl chr10:14,378,120...14,379,867

G

family with sequence similarity 107, member A

increases expression

ISO

Tamoxifen results in increased expression of FAM107A mRNA

NCBI chr15:19,038,726...19,060,644
Ensembl chr15:19,038,616...19,065,219

G

family with sequence similarity 107, member B

affects expression

ISO

Tamoxifen affects the expression of FAM107B mRNA

NCBI chr17:79,387,795...79,594,165
Ensembl chr17:79,387,795...79,594,288

G

family with sequence similarity 110, member A

affects expression

ISO

Tamoxifen affects the expression of FAM110A mRNA

NCBI chr 3:160,934,815...160,945,405
Ensembl chr 3:160,931,777...160,949,897

G

family with sequence similarity 110, member B

decreases expression

ISO

Tamoxifen results in decreased expression of FAM110B mRNA

PMID:17555576 PMID:25123088

NCBI chr 5:23,587,093...23,727,188
Ensembl chr 5:23,586,867...23,799,583

G

family with sequence similarity 110, member C

decreases expression

ISO

Tamoxifen results in decreased expression of FAM110C mRNA

NCBI chr 6:53,366,013...53,372,270
Ensembl chr 6:53,352,870...53,401,117

G

family with sequence similarity 120 member B

affects expression

ISO

Tamoxifen affects the expression of FAM120B mRNA

NCBI chr 1:64,993,104...65,058,160
Ensembl chr 1:65,012,060...65,058,160

G

family with sequence similarity 13, member A

increases expression

ISO

Tamoxifen results in increased expression of FAM13A mRNA

NCBI chr 4:89,386,685...89,485,940
Ensembl chr 4:89,388,569...89,485,988

G

family with sequence similarity 151, member A

increases expression

ISO

Tamoxifen results in increased expression of FAM151A mRNA

NCBI chr 5:126,743,624...126,756,375
Ensembl chr 5:126,743,555...126,756,373

G

family with sequence similarity 163, member A

increases expression

ISO

Tamoxifen results in increased expression of FAM163A mRNA

NCBI chr13:70,813,129...70,891,410
Ensembl chr13:70,813,134...70,891,316

G

family with sequence similarity 171, member B

increases expression

ISO

Tamoxifen results in increased expression of FAM171B mRNA

NCBI chr 3:89,337,566...89,392,973
Ensembl chr 3:89,337,661...89,392,971

G

family with sequence similarity 184, member B

decreases expression

ISO

Tamoxifen results in decreased expression of FAM184B mRNA

NCBI chr14:69,688,031...69,803,922
Ensembl chr14:69,688,031...69,803,922

G

FAM3 metabolism regulating signaling molecule D

affects expression

ISO

Tamoxifen affects the expression of FAM3D mRNA

NCBI chr15:18,969,737...19,003,276
Ensembl chr15:18,969,737...19,004,701

G

family with sequence similarity 53, member B

decreases expression

ISO

Tamoxifen results in decreased expression of FAM53B mRNA

NCBI chr 1:196,930,170...197,021,290
Ensembl chr 1:196,930,175...197,021,290

G

family with sequence similarity 89, member A

decreases expression

ISO

Tamoxifen results in decreased expression of FAM89A mRNA

NCBI chr19:69,607,391...69,620,019
Ensembl chr19:69,607,391...69,620,019

G

FA complementation group A

increases expression

ISO

Tamoxifen results in increased expression of FANCA mRNA

NCBI chr19:68,210,562...68,271,080
Ensembl chr19:68,212,643...68,271,019

G

FA complementation group C

affects expression

ISO

Tamoxifen affects the expression of FANCC mRNA

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,687,017...1,835,096

G

fibroblast activation protein, alpha

affects expression

ISO

Tamoxifen affects the expression of FAP mRNA

NCBI chr 3:67,547,398...67,616,271
Ensembl chr 3:67,546,921...67,617,601

G

phenylalanyl-tRNA synthetase 2, mitochondrial

affects expression

ISO

Tamoxifen affects the expression of FARS2 mRNA

NCBI chr17:28,524,737...28,951,818
Ensembl chr17:28,524,738...28,951,591

G

Fas ligand

multiple interactions
increases expression
decreases expression

EXP
ISO

[BCL2 co-treated with Tamoxifen] results in increased expression of FASL protein; Tamoxifen inhibits the reaction [Estradiol results in increased expression of FASLG protein]
[Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of FASLG mRNA; Tamoxifen results in increased expression of FASLG protein
Tamoxifen results in decreased expression of FASLG mRNA
Tamoxifen results in increased expression of FASL protein
Tamoxifen inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with Estradiol] results in decreased expression of FASLG mRNA]

PMID:12721755 PMID:15545282 PMID:15606891 PMID:20145137 PMID:20529085

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

multiple interactions
decreases expression
increases expression

EXP
ISO

[Tamoxifen co-treated with bexarotene] results in increased expression of FASN mRNA
Tamoxifen results in decreased expression of FASN mRNA
Tamoxifen results in increased expression of FASN mRNA

PMID:17630414 PMID:19224547 PMID:23038002 PMID:25123088

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

F-box DNA helicase 1

affects expression

ISO

Tamoxifen affects the expression of FBH1 mRNA

NCBI chr17:71,659,351...71,697,431
Ensembl chr17:71,659,249...71,697,432

G

fibulin 2

affects expression

ISO

Tamoxifen affects the expression of FBLN2 mRNA

NCBI chr 4:125,261,464...125,321,030
Ensembl chr 4:125,261,607...125,321,029

G

fibulin 5

affects expression

ISO

Tamoxifen affects the expression of FBLN5 mRNA

NCBI chr 6:126,664,100...126,742,847
Ensembl chr 6:126,664,100...126,746,296

G

F-box and leucine-rich repeat protein 12

affects expression

ISO

Tamoxifen affects the expression of FBXL12 mRNA

NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:27,445,823...27,457,772

G

F-box and leucine-rich repeat protein 3

affects expression

ISO

Tamoxifen affects the expression of FBXL3 mRNA

NCBI chr15:86,321,504...86,341,387
Ensembl chr15:86,321,504...86,341,387

G

F-box protein 11

affects expression

ISO

Tamoxifen affects the expression of FBXO11 mRNA

NCBI chr 6:12,240,348...12,316,223
Ensembl chr 6:12,239,801...12,316,221

G

F-box protein 21

affects expression

ISO

Tamoxifen affects the expression of FBXO21 mRNA

NCBI chr12:44,231,918...44,266,035
Ensembl chr12:44,231,923...44,266,035

G

F-box and WD repeat domain containing 11

affects expression

ISO

Tamoxifen affects the expression of FBXW11 mRNA

NCBI chr10:17,737,181...17,834,834
Ensembl chr10:17,720,444...17,834,834

G

F-box and WD repeat domain containing 4

affects expression

ISO

Tamoxifen affects the expression of FBXW4 mRNA

NCBI chr 1:254,375,921...254,465,173
Ensembl chr 1:254,375,923...254,463,277

G

Fc gamma receptor 2A

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of FCGR3 mRNA

NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394

G

Fc gamma receptor 2B

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of FCGR2B mRNA

NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517

G

Fc mu receptor

multiple interactions

ISO

Tamoxifen inhibits the reaction [EGF protein results in increased expression of FCMR mRNA]

NCBI chr13:44,889,628...44,903,926
Ensembl chr13:44,889,697...44,906,314

G

ficolin A

multiple interactions

EXP

[Bexarotene co-treated with Tamoxifen] results in decreased expression of FCNA mRNA

NCBI chr 3:28,844,036...28,847,441
Ensembl chr 3:28,844,039...28,847,237

G

flap structure-specific endonuclease 1

affects expression

ISO

Tamoxifen affects the expression of FEN1 mRNA

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016

G

FYVE, RhoGEF and PH domain containing 4

affects expression

ISO

Tamoxifen affects the expression of FGD4 mRNA

NCBI chr11:97,904,182...98,055,190
Ensembl chr11:97,904,182...98,055,190

G

FYVE, RhoGEF and PH domain containing 6

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA

NCBI chr 7:30,484,600...30,599,898
Ensembl chr 7:30,484,600...30,595,806

G

fibroblast growth factor 2

decreases response to substance
multiple interactions

ISO

FGF2 protein results in decreased susceptibility to Tamoxifen
Tamoxifen inhibits the reaction [FGF2 protein results in increased expression of CCND1 protein]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibroblast growth factor 21

affects expression

ISO

Tamoxifen affects the expression of FGF21 mRNA

NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056

G

fibroblast growth factor 7

decreases response to substance
multiple interactions

ISO

FGF7 results in decreased susceptibility to Tamoxifen
FGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Tamoxifen]

NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328

G

fibroblast growth factor 9

affects expression

ISO

Tamoxifen affects the expression of FGF9 mRNA

NCBI chr15:36,325,552...36,369,995
Ensembl chr15:36,325,599...36,367,926

G

Fibroblast growth factor receptor 1

decreases response to substance

ISO

FGFR1 protein results in decreased susceptibility to Tamoxifen

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

FGFR1 oncogene partner 2

affects expression

ISO

Tamoxifen affects the expression of FGFR1OP2 mRNA

NCBI chr 4:181,222,298...181,243,318
Ensembl chr 4:181,222,323...181,243,322

G

fibroblast growth factor receptor 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA; FGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Tamoxifen]

PMID:18575591 PMID:19059307

NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914

G

fibroblast growth factor receptor 3

decreases expression

ISO

Tamoxifen results in decreased expression of FGFR3 mRNA

NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209

G

fibroblast growth factor receptor-like 1

affects expression

ISO

Tamoxifen affects the expression of FGFRL1 mRNA

NCBI chr14:1,154,275...1,166,334
Ensembl chr14:1,154,275...1,166,752

G

fumarate hydratase

affects expression

ISO

Tamoxifen affects the expression of FH1 mRNA

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

four and a half LIM domains 1

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of FHL1 mRNA
Tamoxifen inhibits the reaction [Estradiol results in decreased expression of FHL1 mRNA]

PMID:17555576 PMID:20149813

NCBI chr X:139,592,794...139,652,290
Ensembl chr X:139,592,604...139,652,282

G

four and a half LIM domains 2

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of FHL2 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA

PMID:14699072 PMID:17555576 PMID:19059307

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

FGF1 intracellular binding protein

affects expression

ISO

Tamoxifen affects the expression of FIBP mRNA

NCBI chr 1:212,197,216...212,201,732
Ensembl chr 1:212,197,416...212,201,731

G

FIC domain protein adenylyltransferase

increases expression

ISO

Tamoxifen results in increased expression of FICD mRNA

NCBI chr12:48,549,737...48,554,626
Ensembl chr12:48,549,737...48,554,626

G

FKBP prolyl isomerase 1B

increases expression

ISO

Tamoxifen results in increased expression of FKBP1B mRNA

NCBI chr 6:33,551,583...33,570,055
Ensembl chr 6:33,558,517...33,568,129

G

FKBP prolyl isomerase 4

affects expression

ISO

Tamoxifen affects the expression of FKBP4 mRNA

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918

G

FKBP prolyl isomerase 5

affects expression

ISO

Tamoxifen affects the expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

FKBP prolyl isomerase like

multiple interactions
increases response to substance

ISO

FKBPL protein inhibits the reaction [Tamoxifen results in increased phosphorylation of ESR1 protein]
FKBPL protein results in increased susceptibility to Tamoxifen

NCBI chr20:4,104,457...4,105,927
Ensembl chr20:4,104,019...4,105,615

G

filamin B

multiple interactions
increases expression
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FLNB mRNA
Tamoxifen results in increased expression of FLNB mRNA
Tamoxifen affects the expression of FLNB mRNA

PMID:14699072 PMID:19059307 PMID:25123088

NCBI chr15:19,392,212...19,525,278
Ensembl chr15:19,392,216...19,525,209

G

filamin C

affects expression

ISO

Tamoxifen affects the expression of FLNC mRNA

NCBI chr 4:58,999,445...59,027,240
Ensembl chr 4:58,999,547...59,027,240

G

flotillin 1

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Tamoxifen results in increased expression of FLOT1 mRNA]
Tamoxifen affects the expression of FLOT1 mRNA

PMID:14699072 PMID:17555576

NCBI chr20:2,922,662...2,932,906
Ensembl chr20:2,922,655...2,932,771

G

fibronectin leucine rich transmembrane protein 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of FLRT1 mRNA
Tamoxifen results in increased expression of FLRT1 mRNA

PMID:14699072 PMID:25123088

NCBI chr 1:213,704,983...213,782,958
Ensembl chr 1:213,704,038...213,782,981

G

FLYWCH family member 2

affects expression

ISO

Tamoxifen affects the expression of FLYWCH2 mRNA

NCBI chr10:13,303,346...13,311,677
Ensembl chr10:13,303,321...13,311,657

G

formin-like 1

affects expression

ISO

Tamoxifen affects the expression of FMNL1 mRNA

NCBI chr10:88,615,290...88,643,411
Ensembl chr10:88,615,869...88,643,411

G

flavin containing dimethylaniline monoxygenase 1

affects expression

ISO

Tamoxifen affects the expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

flavin containing dimethylaniline monoxygenase 3

decreases expression

ISO

Tamoxifen results in decreased expression of FMO3 mRNA

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256

G

flavin containing dimethylaniline monoxygenase 4

decreases expression

ISO

Tamoxifen results in decreased expression of FMO4 mRNA

NCBI chr13:77,687,909...77,706,100
Ensembl chr13:77,687,909...77,706,100

G

flavin containing dimethylaniline monoxygenase 5

affects expression

ISO

Tamoxifen affects the expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

fragile X messenger ribonucleoprotein 1

decreases expression

ISO

Tamoxifen results in decreased expression of FMR1 mRNA

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675

G

fibronectin 1

affects expression

ISO

Tamoxifen affects the expression of FN1 mRNA

PMID:14699072 PMID:20937368

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

formin binding protein 1-like

affects expression

ISO

Tamoxifen affects the expression of FNBP1L mRNA

NCBI chr 2:213,331,871...213,432,821
Ensembl chr 2:213,318,662...213,423,051

G

formin binding protein 4

affects expression

ISO

Tamoxifen affects the expression of FNBP4 mRNA

NCBI chr 3:97,188,852...97,218,916
Ensembl chr 3:97,188,884...97,219,435

G

fibronectin type III domain containing 4

increases expression

ISO

Tamoxifen results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO
EXP

Tamoxifen promotes the reaction [ESR2 protein binds to [[FOS protein binds to JUN protein] which binds to PTPRO promoter]]; Tamoxifen promotes the reaction [FOS protein binds to MMP1 promoter]
Tamoxifen results in increased expression of FOS mRNA

PMID:17157789 PMID:17555576 PMID:19095770 PMID:19400957 PMID:19432593

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

affects expression

ISO

Tamoxifen affects the expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box A1

multiple interactions
decreases expression

ISO

FOXA1 protein affects the reaction [Tamoxifen affects the activity of ESR1 protein]
Tamoxifen results in decreased expression of FOXA1 mRNA

PMID:21151129 PMID:27089845

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191

G

forkhead box A3

affects expression

ISO

Tamoxifen affects the expression of FOXA3 mRNA

NCBI chr 1:87,790,111...87,800,259
Ensembl chr 1:87,790,012...87,800,953

G

forkhead box C1

affects expression

ISO

Tamoxifen affects the expression of FOXC1 mRNA

NCBI chr17:32,840,119...32,844,100
Ensembl chr17:32,805,858...32,844,347

G

forkhead box J3

increases expression

ISO

Tamoxifen results in increased expression of FOXJ3 mRNA

NCBI chr 5:138,425,623...138,513,760
Ensembl chr 5:138,424,923...138,513,760

G

forkhead box L2

multiple interactions
decreases expression

ISO

FOXL2 protein inhibits the reaction [[Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA]; Tamoxifen promotes the reaction [ESR1 protein binds to FOXL2 protein]
Tamoxifen results in decreased expression of FOXL2 mRNA; Tamoxifen results in decreased expression of FOXL2 protein

PMID:19797124 PMID:24769059

NCBI chr 8:108,392,466...108,395,553
Ensembl chr 8:108,382,872...108,396,835

G

forkhead box M1

multiple interactions
decreases expression
decreases response to substance

ISO

ESR1 protein inhibits the reaction [Tamoxifen results in decreased expression of FOXM1 mRNA]; ESR1 protein promotes the reaction [Tamoxifen results in decreased expression of FOXM1 protein]; FOXM1 protein affects the reaction [ESR1 protein results in increased susceptibility to Tamoxifen]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]; Tamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter]; Tamoxifen promotes the reaction [HDAC2 protein binds to FOXM1 promoter]
Tamoxifen results in decreased expression of FOXM1 mRNA; Tamoxifen results in decreased expression of FOXM1 protein
FOXM1 protein results in decreased susceptibility to Tamoxifen

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172

G

forkhead box N3

increases expression
affects expression

ISO

Tamoxifen results in increased expression of FOXN3 mRNA
Tamoxifen affects the expression of CHES1 mRNA

PMID:15849065 PMID:17555576

NCBI chr 6:124,191,695...124,572,070
Ensembl chr 6:124,195,701...124,572,040

G

forkhead box O1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA; ESR1 protein affects the reaction [Tamoxifen results in increased expression of FOXO1 mRNA]
Tamoxifen affects the expression of FOXO1 mRNA

PMID:14699072 PMID:19059307 PMID:20937368

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O3

affects expression
multiple interactions
affects localization

ISO

Tamoxifen affects the expression of FOXO3 mRNA
GPER1 protein affects the reaction [Tamoxifen affects the localization of FOXO3 protein]

PMID:17555576 PMID:26470790

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

forkhead box P3

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of FOXP3 mRNA
TGFB1 protein promotes the reaction [Tamoxifen results in increased expression of FOXP3 mRNA]

NCBI chr X:17,580,380...17,601,181
Ensembl chr X:17,580,380...17,595,894

G

forkhead box Q1

affects expression

ISO

Tamoxifen affects the expression of FOXQ1 mRNA

NCBI chr17:33,121,454...33,124,087
Ensembl chr17:33,121,545...33,123,720

G

folylpolyglutamate synthase

affects expression

ISO

Tamoxifen affects the expression of FPGS mRNA

NCBI chr 3:36,370,505...36,391,314
Ensembl chr 3:36,370,300...36,391,068

G

formyl peptide receptor 2

affects expression

ISO

Tamoxifen affects the expression of FPR2 mRNA

NCBI chr 1:67,449,637...67,458,272
Ensembl chr 1:67,449,637...67,458,272

G

FERM domain containing 8

increases expression

ISO

Tamoxifen results in increased expression of FRMD8 mRNA

NCBI chr 1:212,572,534...212,593,181
Ensembl chr 1:212,572,537...212,592,695

G

frizzled-related protein

increases expression

ISO

Tamoxifen results in increased expression of FRZB mRNA

NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:85,739,165...85,772,096

G

fascin actin-bundling protein 1

affects expression

ISO

Tamoxifen affects the expression of FSCN1 mRNA

PMID:17555576 PMID:20937368

NCBI chr12:16,710,601...16,723,734
Ensembl chr12:16,710,601...16,723,734

G

fascin actin-bundling protein 3

affects expression

ISO

Tamoxifen affects the expression of FSCN3 mRNA

NCBI chr 4:58,008,124...58,017,674
Ensembl chr 4:58,008,230...58,017,673

G

follicle stimulating hormone subunit beta

decreases expression
decreases secretion

ISO
EXP

Tamoxifen results in decreased expression of FSHB protein
Tamoxifen results in decreased secretion of FSHB protein
Tamoxifen results in decreased expression of FSHB mRNA

PMID:9208491 PMID:27395752

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

follistatin

affects expression
decreases expression
multiple interactions

ISO

Tamoxifen affects the expression of FST mRNA
Tamoxifen results in decreased expression of FST mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FST mRNA

PMID:14699072 PMID:16298037 PMID:19059307

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491

G

far upstream element binding protein 1

affects expression

ISO

Tamoxifen affects the expression of FUBP1 mRNA

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:243,819,218...243,846,428

G

alpha-L-fucosidase 1

affects expression

ISO

Tamoxifen affects the expression of FUCA1 mRNA

NCBI chr 5:153,436,262...153,453,512
Ensembl chr 5:153,436,248...153,453,511

G

Fus RNA binding protein

decreases expression

ISO

Tamoxifen results in decreased expression of FUS mRNA

NCBI chr 1:192,007,011...192,020,887
Ensembl chr 1:192,007,006...192,020,884

G

fucosyltransferase 10

increases expression

ISO

Tamoxifen results in increased expression of POFUT3 mRNA

NCBI chr16:67,571,828...67,661,814
Ensembl chr16:67,581,565...67,661,753

G

fucosyltransferase 8

decreases expression

ISO

Tamoxifen results in decreased expression of FUT8 mRNA

NCBI chr 6:101,682,354...101,909,784
Ensembl chr 6:101,683,007...101,909,775

G

fucosyltransferase 9

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of FUT9 mRNA

NCBI chr 5:44,148,371...44,361,209
Ensembl chr 5:44,146,152...44,362,823

G

FXYD domain-containing ion transport regulator 4

affects expression

ISO

Tamoxifen affects the expression of FXYD4 mRNA

NCBI chr 4:152,782,181...152,786,118
Ensembl chr 4:152,782,181...152,786,039

G

frizzled class receptor 2

increases expression

ISO

Tamoxifen results in increased expression of FZD2 mRNA

NCBI chr10:88,061,988...88,063,898
Ensembl chr10:88,061,667...88,065,396

G

frizzled class receptor 6

affects expression

ISO

Tamoxifen affects the expression of FZD6 mRNA

NCBI chr 7:71,939,916...71,971,685
Ensembl chr 7:71,939,973...71,971,680

G

frizzled class receptor 7

affects expression
increases expression

ISO

Tamoxifen affects the expression of FZD7 mRNA
Tamoxifen results in increased expression of FZD7 mRNA

PMID:17555576 PMID:25123088

NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:68,411,259...68,432,585

G

frizzled class receptor 8

decreases expression

ISO

Tamoxifen results in decreased expression of FZD8 mRNA

NCBI chr17:62,007,849...62,015,485
Ensembl chr17:62,007,627...62,015,961

G

fizzy and cell division cycle 20 related 1

affects expression

ISO

Tamoxifen affects the expression of FZR1 mRNA

NCBI chr 7:8,982,765...8,994,689
Ensembl chr 7:8,989,769...8,995,199

G

G0/G1switch 2

multiple interactions
decreases expression
affects expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of G0S2 mRNA; ESR1 protein affects the reaction [Tamoxifen results in increased expression of G0S2 mRNA]
Tamoxifen results in decreased expression of G0S2 mRNA
Tamoxifen affects the expression of G0S2 mRNA

PMID:14699072 PMID:17555576 PMID:19059307 PMID:20937368 PMID:25123088

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

glucose-6-phosphate dehydrogenase

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of G6PD mRNA
Tamoxifen results in increased expression of G6PDX mRNA

PMID:14699072 PMID:19224547

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GRB2-associated binding protein 1

affects expression

ISO

Tamoxifen affects the expression of GAB1 mRNA

NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617

G

glutamate decarboxylase 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of GAD1 mRNA

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

glutamate decarboxylase 2

affects expression
increases expression

ISO

Tamoxifen affects the expression of GAD2 mRNA
Tamoxifen results in increased expression of GAD2 mRNA

PMID:17555576 PMID:25123088

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

growth arrest and DNA-damage-inducible, alpha

increases expression
decreases expression
multiple interactions
affects expression

ISO

Tamoxifen results in increased expression of GADD45A mRNA
Tamoxifen results in decreased expression of GADD45A mRNA
Tamoxifen inhibits the reaction [EGF protein results in increased expression of GADD45A mRNA]; TP53 protein promotes the reaction [Tamoxifen results in increased expression of GADD45A mRNA]
Tamoxifen affects the expression of GADD45A mRNA

PMID:15604281 PMID:20549698 PMID:20937368 PMID:24758408 PMID:25123088

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, gamma

affects expression

ISO

Tamoxifen affects the expression of GADD45G mRNA

PMID:17555576 PMID:20937368

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369

G

galanin and GMAP prepropeptide

decreases expression

ISO

Tamoxifen results in decreased expression of GAL mRNA

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

galactosylceramidase

affects expression

ISO

Tamoxifen affects the expression of GALC mRNA

NCBI chr 6:123,182,636...123,252,024
Ensembl chr 6:123,182,643...123,245,578

G

galactosamine (N-acetyl)-6-sulfatase

affects expression

ISO

Tamoxifen affects the expression of GALNS mRNA

NCBI chr19:67,537,175...67,570,900
Ensembl chr19:67,534,737...67,571,191

G

polypeptide N-acetylgalactosaminyltransferase 10

increases expression

ISO

Tamoxifen results in increased expression of GALNT10 mRNA

NCBI chr10:42,321,691...42,468,087
Ensembl chr10:42,322,161...42,468,087

G

polypeptide N-acetylgalactosaminyltransferase 2

affects expression

ISO

Tamoxifen affects the expression of GALNT2 mRNA

NCBI chr19:69,110,657...69,222,237
Ensembl chr19:69,110,657...69,222,237

G

polypeptide N-acetylgalactosaminyltransferase 3

affects expression

ISO

Tamoxifen affects the expression of GALNT3 mRNA

NCBI chr 3:71,150,559...71,187,321
Ensembl chr 3:71,150,571...71,174,323

G

galactose-1-phosphate uridylyltransferase

affects expression

ISO

Tamoxifen affects the expression of GALT mRNA

PMID:14699072 PMID:17555576

NCBI chr 5:61,722,871...61,726,128
Ensembl chr 5:61,722,466...61,726,125

G

glucosidase II alpha subunit

affects expression

ISO

Tamoxifen affects the expression of GANAB mRNA

NCBI chr 1:215,222,918...215,242,808
Ensembl chr 1:215,222,995...215,243,036

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

affects expression

ISO

Tamoxifen affects the expression of GART mRNA

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

growth arrest-specific 1

affects expression

ISO

Tamoxifen affects the expression of GAS1 mRNA

PMID:14699072 PMID:17555576

NCBI chr17:4,487,716...4,490,701
Ensembl chr17:4,484,283...4,497,657

G

growth arrest specific 6

multiple interactions
increases expression

ISO
EXP

fulvestrant inhibits the reaction [Tamoxifen results in increased expression of GAS6 mRNA]
[bexarotene co-treated with Tamoxifen] results in decreased expression of GAS6 mRNA

PMID:17630414 PMID:19429434

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

growth arrest specific 7

increases expression

ISO

Tamoxifen results in increased expression of GAS7 mRNA

NCBI chr10:52,651,690...52,882,244
Ensembl chr10:52,651,690...52,882,244

G

GATA binding protein 2

affects expression

ISO

Tamoxifen affects the expression of GATA2 mRNA

PMID:14699072 PMID:17555576

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

GATA binding protein 3

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of GATA3 mRNA
ESR1 protein affects the reaction [GATA3 protein affects the susceptibility to Tamoxifen]

PMID:19031437 PMID:19084267

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670

G

GATA binding protein 4

decreases expression

ISO

Tamoxifen results in decreased expression of GATA4 mRNA

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

GATA zinc finger domain containing 1

affects expression

ISO

Tamoxifen affects the expression of GATAD1 mRNA

NCBI chr 4:31,462,251...31,473,827
Ensembl chr 4:31,462,309...31,503,921

G

glycine amidinotransferase

affects expression

ISO

Tamoxifen affects the expression of GATM mRNA

NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355

G

guanylate binding protein 4

affects expression

ISO

Tamoxifen affects the expression of GBP4 mRNA

NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:233,978,486...233,992,120

G

guanylate binding protein family member 6

affects expression
decreases expression

ISO

Tamoxifen affects the expression of GBP6 mRNA
Tamoxifen results in decreased expression of GBP6 mRNA

PMID:20937368 PMID:25123088

NCBI chr14:5,034,999...5,062,023
Ensembl chr14:4,968,325...4,983,692
Ensembl chr14:4,968,325...4,983,692

G

grancalcin

affects expression

ISO

Tamoxifen affects the expression of GCA mRNA

NCBI chr 3:67,705,874...67,738,475
Ensembl chr 3:67,705,890...67,737,387

G

glucokinase

affects expression

ISO

Tamoxifen affects the expression of GCK mRNA

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

glutamate-cysteine ligase, catalytic subunit

affects expression

ISO

Tamoxifen affects the expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

growth differentiation factor 10

affects expression

ISO

Tamoxifen affects the expression of GDF10 mRNA

PMID:17555576 PMID:20937368

NCBI chr16:9,243,434...9,256,788
Ensembl chr16:9,243,317...9,256,794

G

growth differentiation factor 15

affects expression
increases expression
decreases response to substance

ISO

Tamoxifen affects the expression of GDF15 mRNA
Tamoxifen results in increased expression of GDF15 mRNA
GDF15 protein results in decreased susceptibility to Tamoxifen

PMID:20937368 PMID:22615612 PMID:25123088

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

growth differentiation factor 3

affects expression

ISO

Tamoxifen affects the expression of GDF3 mRNA

NCBI chr 4:157,503,547...157,507,923
Ensembl chr 4:157,502,884...157,507,907

G

growth differentiation factor 6

increases expression

ISO

Tamoxifen results in increased expression of GDF6 mRNA

NCBI chr 5:27,793,561...27,809,884
Ensembl chr 5:27,793,552...27,811,825

G

growth differentiation factor 9

increases expression

ISO

Tamoxifen results in increased expression of GDF9 mRNA

NCBI chr10:38,090,021...38,100,801
Ensembl chr10:38,089,878...38,100,797

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

ISO

Tamoxifen results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606

G

GTP binding protein overexpressed in skeletal muscle

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of GEM mRNA
Tamoxifen inhibits the reaction [Estradiol results in increased expression of GEM mRNA]

PMID:24758408 PMID:25123088

NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542

G

gem (nuclear organelle) associated protein 2

affects expression

ISO

Tamoxifen affects the expression of GEMIN2 mRNA

NCBI chr 6:82,442,419...82,456,050
Ensembl chr 6:82,442,350...82,456,048

G

glial fibrillary acidic protein

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of GFAP mRNA
Tamoxifen inhibits the reaction [bisphenol A results in increased expression of GFAP protein]

PMID:16860915 PMID:17555576

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

growth factor independent 1 transcriptional repressor

increases expression

ISO

Tamoxifen results in increased expression of GFI1 mRNA

NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,187,286...2,196,730

G

G elongation factor, mitochondrial 1

affects expression

ISO

Tamoxifen affects the expression of GFM1 mRNA

NCBI chr 2:154,010,601...154,055,523
Ensembl chr 2:154,010,614...154,065,805

G

glutamine fructose-6-phosphate transaminase 1

increases expression

ISO

Tamoxifen results in increased expression of GFPT1 mRNA

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799

G

GDNF family receptor alpha 2

multiple interactions

ISO

Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of GFRA2 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of GFRA2 mRNA]

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782

G

golgi associated, gamma adaptin ear containing, ARF binding protein 3

affects expression

ISO

Tamoxifen affects the expression of GGA3 mRNA

NCBI chr10:101,324,378...101,342,373
Ensembl chr10:101,324,378...101,342,373

G

gamma-glutamyl cyclotransferase

affects expression
increases expression

ISO

Tamoxifen affects the expression of GGCT mRNA
Tamoxifen results in increased expression of GGCT mRNA

PMID:17555576 PMID:20937368 PMID:25123088

NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:85,453,387...85,470,224

G

growth hormone 1

decreases secretion
multiple interactions

EXP
ISO

Tamoxifen results in decreased secretion of GH1 protein
Tamoxifen inhibits the reaction [Estradiol results in increased expression of GH mRNA]
Tamoxifen promotes the reaction [SST protein results in decreased secretion of GH1 protein]

PMID:1350760 PMID:22349083

NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859

G

growth hormone inducible transmembrane protein

affects expression

ISO

Tamoxifen affects the expression of GHITM mRNA

NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123

G

growth hormone receptor

affects expression

ISO

Tamoxifen affects the expression of GHR mRNA

NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331

G

gastric inhibitory polypeptide

increases expression

ISO

Tamoxifen results in increased expression of GIP mRNA

NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216

G

GIT ArfGAP 2

affects expression

ISO

Tamoxifen affects the expression of GIT2 mRNA

NCBI chr12:47,490,350...47,531,232
Ensembl chr12:47,490,369...47,533,250

G

gap junction protein, alpha 1

affects expression
increases expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of GJA1 mRNA
Tamoxifen results in increased expression of GJA1 mRNA
Tamoxifen inhibits the reaction [Estradiol affects the expression of GJA1 mRNA]

PMID:14699072 PMID:17555576 PMID:20004189 PMID:25123088

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

gap junction protein, beta 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with Tamoxifen] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with Tamoxifen] results in decreased expression of GJB1 protein

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

gap junction protein, beta 2

increases expression

ISO

Tamoxifen results in increased expression of GJB2 mRNA

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877

G

gap junction protein, beta 5

affects expression

ISO

Tamoxifen affects the expression of GJB5 mRNA

NCBI chr 5:144,965,133...144,968,051
Ensembl chr 5:144,964,751...144,984,021

G

galactosidase, beta 1

affects expression

ISO

Tamoxifen affects the expression of GLB1 mRNA

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

golgi glycoprotein 1

affects expression

ISO

Tamoxifen affects the expression of GLG1 mRNA

NCBI chr19:56,034,248...56,133,538
Ensembl chr19:56,006,459...56,133,528

G

GLI family zinc finger 1

affects expression

ISO

Tamoxifen affects the expression of GLI1 mRNA

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540

G

glycine receptor, beta

affects expression

ISO

Tamoxifen affects the expression of GLRB mRNA

NCBI chr 2:168,432,736...168,505,614
Ensembl chr 2:168,432,736...168,505,614

G

glutaredoxin 3

increases expression

ISO
EXP

Tamoxifen results in increased expression of GLRX3 mRNA

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glutaredoxin 5

affects expression

ISO

Tamoxifen affects the expression of GLRX5 mRNA

NCBI chr 6:129,752,902...129,763,278
Ensembl chr 6:129,752,840...129,763,278

G

glutamate dehydrogenase 1

decreases expression
multiple interactions

ISO

Tamoxifen results in decreased expression of GLUD1 protein
[Tretinoin co-treated with Tamoxifen] results in decreased expression of GLUD1 protein

NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210

G

glutamate-ammonia ligase

affects expression
decreases expression

ISO

Tamoxifen affects the expression of GLUL mRNA
Tamoxifen results in decreased expression of GLUL mRNA

PMID:17555576 PMID:25123088

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

glycine-N-acyltransferase

affects expression

ISO

Tamoxifen affects the expression of GLYAT mRNA

NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:219,128,811...219,150,774

G

Gem-interacting protein

affects expression

ISO

Tamoxifen affects the expression of GMIP mRNA

NCBI chr16:19,634,630...19,648,916
Ensembl chr16:19,634,630...19,647,933

G

G protein subunit alpha o1

affects expression

ISO

Tamoxifen affects the expression of GNAO1 mRNA

NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,040,788...11,198,437

G

G protein subunit alpha transducin 1

affects expression
decreases expression

ISO

Tamoxifen affects the expression of GNAT1 mRNA
Tamoxifen results in decreased expression of GNAT1 mRNA

PMID:20937368 PMID:25123088

NCBI chr 8:117,229,575...117,234,311
Ensembl chr 8:117,229,575...117,234,311

G

G protein subunit beta 4

increases expression

ISO

Tamoxifen results in increased expression of GNB4 mRNA

NCBI chr 2:117,289,112...117,329,050
Ensembl chr 2:117,293,284...117,328,945

G

G protein nucleolar 3

affects expression

ISO

Tamoxifen affects the expression of GNL3 mRNA

NCBI chr16:6,213,844...6,220,029
Ensembl chr16:6,213,871...6,219,845

G

gonadotropin releasing hormone 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [[Progesterone co-treated with Estradiol] results in increased secretion of GNRH1 protein]; Tamoxifen inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]

PMID:3299987 PMID:10566683

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

golgi reassembly stacking protein 2

affects expression

ISO

Tamoxifen affects the expression of GORASP2 mRNA

NCBI chr 3:75,882,607...75,911,322
Ensembl chr 3:75,882,515...75,911,328

G

golgi SNAP receptor complex member 1

affects expression

ISO

Tamoxifen affects the expression of GOSR1 mRNA

NCBI chr10:62,068,662...62,105,442
Ensembl chr10:61,948,693...62,105,324

G

golgi SNAP receptor complex member 2

affects expression

ISO

Tamoxifen affects the expression of GOSR2 mRNA

NCBI chr10:89,085,323...89,105,665
Ensembl chr10:89,086,331...89,105,637

G

glutamic-oxaloacetic transaminase 1

affects expression
increases activity
multiple interactions

ISO
EXP

Tamoxifen affects the expression of GOT1 mRNA
Tamoxifen results in increased activity of GOT1 protein
zinc chloride inhibits the reaction [Tamoxifen results in increased activity of GOT1 protein]

PMID:17555576 PMID:20937368 PMID:31532279

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glycerol-3-phosphate acyltransferase 3

increases expression

ISO

Tamoxifen results in increased expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552

G

glypican 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of GPC1 mRNA
Tamoxifen results in increased expression of GPC1 mRNA

PMID:14699072 PMID:25123088

NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:100,843,645...100,879,933

G

glycerophosphocholine phosphodiesterase 1

affects expression

ISO

Tamoxifen affects the expression of GPCPD1 mRNA

NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:140,240,575...140,285,372

G

glycerol-3-phosphate dehydrogenase 2

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of GPD2 mRNA

NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593

G

G protein-coupled estrogen receptor 1

multiple interactions
decreases expression
decreases response to substance
increases activity

ISO

[Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein; GPER1 protein affects the reaction [Tamoxifen affects the localization of FOXO3 protein]; GPER1 protein promotes the reaction [Tamoxifen results in increased expression of ESRRA mRNA]; Tamoxifen inhibits the reaction [Quercetin results in increased expression of GPER1 mRNA]
Tamoxifen results in decreased expression of GPER1 mRNA; Tamoxifen results in decreased expression of GPER1 protein
GPER1 protein results in decreased susceptibility to Tamoxifen
Tamoxifen analog results in increased activity of GPER1 protein

PMID:19549922 PMID:19911269 PMID:20211987 PMID:26470790 PMID:30153467 More...

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

glycosylphosphatidylinositol specific phospholipase D1

affects expression

ISO

Tamoxifen affects the expression of GPLD1 mRNA

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975

G

glycoprotein m6a

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of GPM6A mRNA

NCBI chr16:43,374,385...43,706,461
Ensembl chr16:43,374,385...43,706,705

G

glycoprotein nmb

affects expression

ISO

Tamoxifen affects the expression of GPNMB mRNA

NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240

G

G protein-coupled receptor 146

affects expression

ISO

Tamoxifen affects the expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

G protein-coupled receptor 35

affects expression

ISO

Tamoxifen affects the expression of GPR35 mRNA

NCBI chr 9:100,974,580...100,995,330
Ensembl chr 9:100,962,538...100,986,985

G

G protein-coupled receptor 83

affects expression

ISO

Tamoxifen affects the expression of GPR83 mRNA

NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:19,974,993...19,985,490

G

G protein-coupled receptor, class C, group 5, member C

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA

NCBI chr10:100,385,682...100,407,953
Ensembl chr10:100,383,631...100,426,962

G

G protein pathway suppressor 2

multiple interactions
affects expression

ISO

Tamoxifen promotes the reaction [GPS2 protein binds to TFF1 promoter]
Tamoxifen affects the expression of GPS2 mRNA

PMID:17555576 PMID:19858209

NCBI chr10:55,136,043...55,139,106
Ensembl chr10:55,136,169...55,139,862

G

G-protein signaling modulator 2

increases expression
affects expression

ISO

Tamoxifen results in increased expression of GPSM2 mRNA
Tamoxifen affects the expression of GPSM2 mRNA

PMID:15590111 PMID:17555576 PMID:20937368

NCBI chr 2:199,015,250...199,063,788
Ensembl chr 2:199,015,250...199,063,056

G

glutamic--pyruvic transaminase

affects expression
increases activity
multiple interactions

ISO
EXP

Tamoxifen affects the expression of GPT mRNA
Tamoxifen results in increased activity of GPT protein
zinc chloride inhibits the reaction [Tamoxifen results in increased activity of GPT protein]
Tamoxifen inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]

PMID:17555576 PMID:29974145 PMID:31532279

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

decreases activity
multiple interactions

EXP

Tamoxifen results in decreased activity of GPX1 protein
zinc chloride inhibits the reaction [Tamoxifen results in decreased activity of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

GRB2-related adaptor protein

affects expression

ISO

Tamoxifen affects the expression of GRAP mRNA

NCBI chr10:46,798,423...46,851,524
Ensembl chr10:46,832,390...46,851,523

G

growth factor receptor bound protein 10

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of GRB10 mRNA

NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387

G

growth factor receptor bound protein 7

decreases response to substance
affects expression

ISO

GRB7 protein results in decreased susceptibility to Tamoxifen
Tamoxifen affects the expression of GRB7 mRNA

PMID:17555576 PMID:19075277

NCBI chr10:83,936,538...83,949,344
Ensembl chr10:83,939,299...83,949,382

G

growth regulating estrogen receptor binding 1

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of GREB1 mRNA
Tamoxifen inhibits the reaction [Oleic Acid results in increased expression of GREB1 mRNA]

PMID:25123088 PMID:38191086

NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126

G

gremlin 2, DAN family BMP antagonist

affects expression

ISO

Tamoxifen affects the expression of GREM2 mRNA

NCBI chr13:89,310,897...89,403,856
Ensembl chr13:89,310,662...89,404,312

G

glutamate ionotropic receptor NMDA type subunit 3B

decreases expression

ISO

Tamoxifen results in decreased expression of GRIN3B mRNA

NCBI chr 7:10,381,495...10,387,817
Ensembl chr 7:10,381,496...10,387,817

G

G protein-coupled receptor kinase 5

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of GRK5 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of GRK5 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928

G

granulin precursor

affects expression

ISO

Tamoxifen affects the expression of GRN mRNA

NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,886,122...87,893,936

G

glycogen synthase kinase 3 beta

multiple interactions
affects phosphorylation

ISO

Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein]; Tamoxifen results in decreased phosphorylation of and results in increased expression of GSK3B protein
Tamoxifen affects the phosphorylation of GSK3B protein

PMID:22046442 PMID:23921149 PMID:34463000

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

G1 to S phase transition 1

affects expression

ISO

Tamoxifen affects the expression of GSPT1 mRNA

NCBI chr10:4,867,687...4,904,186
Ensembl chr10:4,869,465...4,908,040

G

glutathione-disulfide reductase

affects expression

ISO

Tamoxifen affects the expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 1

decreases activity
decreases expression

EXP

Tamoxifen results in decreased activity of GSTA1 protein
Tamoxifen metabolite results in decreased expression of GSTA1 mRNA; Tamoxifen results in decreased expression of GSTA1 mRNA; Tamoxifen results in decreased expression of GSTA1 protein

PMID:8706011 PMID:9744569

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase alpha 2

decreases expression
decreases activity

EXP

Tamoxifen results in decreased expression of GSTA2 mRNA; Tamoxifen results in decreased expression of GSTA2 protein
Tamoxifen results in decreased activity of GSTA2 protein

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 3

increases expression

EXP

Tamoxifen results in increased expression of GSTA3 mRNA; Tamoxifen results in increased expression of GSTA3 protein

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase alpha 4

affects expression

ISO

Tamoxifen affects the expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase mu 1

multiple interactions

ISO

[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase, mu 5

affects expression

ISO

Tamoxifen affects the expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase omega 2

decreases expression

ISO

Tamoxifen results in decreased expression of GSTO2 mRNA

NCBI chr 1:256,673,376...256,695,154
Ensembl chr 1:256,673,274...256,695,146

G

glutathione S-transferase pi 1

affects response to substance
increases expression

ISO
EXP

GSTP1 protein polymorphism affects the susceptibility to Tamoxifen
Tamoxifen results in increased expression of GSTP2 mRNA
Tamoxifen results in increased expression of GSTP1 mRNA

PMID:15565566 PMID:19224547 PMID:25123088

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

general transcription factor II I

affects expression

ISO

Tamoxifen affects the expression of GTF2I mRNA

NCBI chr12:28,037,344...28,112,677
Ensembl chr12:28,037,853...28,112,677

G

GTF2I repeat domain containing 1

affects expression

ISO

Tamoxifen affects the expression of GTF2IRD1 mRNA

NCBI chr12:27,890,594...27,997,506
Ensembl chr12:27,890,675...27,997,494

G

GTP binding protein 1

affects expression

ISO

Tamoxifen affects the expression of GTPBP1 mRNA

NCBI chr 7:113,128,645...113,153,094
Ensembl chr 7:113,128,670...113,154,621

G

GTP binding protein 4

affects expression

ISO

Tamoxifen affects the expression of GTPBP4 mRNA

NCBI chr17:65,997,472...66,019,530
Ensembl chr17:66,276,566...66,289,637

G

guanylate cyclase activator 2B

affects expression

ISO

Tamoxifen affects the expression of GUCA2B mRNA

NCBI chr 5:138,532,160...138,534,210
Ensembl chr 5:138,532,178...138,534,235

G

glycogenin 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of GYG1 mRNA

NCBI chr 2:104,540,927...104,583,038
Ensembl chr 2:104,540,533...104,582,818

G

glycophorin C

decreases expression

ISO

Tamoxifen results in decreased expression of GYPC mRNA

NCBI chr18:24,434,921...24,467,592
Ensembl chr18:24,434,922...24,440,053

G

granzyme A

multiple interactions

ISO

[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

granzyme B

decreases expression
multiple interactions
increases expression

ISO

Tamoxifen results in decreased expression of GZMB mRNA; Tamoxifen results in decreased expression of GZMB protein
[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of GZMB mRNA
[Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNA

PMID:20145137 PMID:35468944

NCBI chr15:34,459,007...34,462,469
Ensembl chr15:34,459,007...34,462,469

G

H19 imprinted maternally expressed transcript

multiple interactions
increases expression
affects expression

EXP
ISO

Tamoxifen inhibits the reaction [ESR2 protein binds to H19 gene]
Tamoxifen results in increased expression of H19 mRNA
Tamoxifen affects the expression of H19 mRNA

PMID:17555576 PMID:17962382 PMID:19683557

NCBI chr 1:207,160,175...207,162,851

G

H1.0 linker histone

affects expression

ISO

Tamoxifen affects the expression of H1-0 mRNA
Tamoxifen affects the expression of H1F0 mRNA

PMID:14699072 PMID:17555576

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:112,473,222...112,475,006

G

H1.2 linker histone, cluster member

affects expression

ISO

Tamoxifen affects the expression of H1F2 mRNA

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

H2A.Z variant histone 1

decreases expression
affects expression

ISO

Tamoxifen results in decreased expression of H2AZ1 mRNA
Tamoxifen affects the expression of H2AZ1 mRNA

PMID:17555576 PMID:20543978

NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:229,028,843...229,031,411

G

H2A.Z variant histone 2

affects expression

ISO

Tamoxifen affects the expression of H2AZ2 mRNA

NCBI chr14:85,507,228...85,526,166
Ensembl chr14:85,507,228...85,526,207
Ensembl chr16:85,507,228...85,526,207

G

H3.3 histone B

affects expression

ISO

Tamoxifen affects the expression of H3F3B mRNA

NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,755,404...101,757,636

G

hepcidin antimicrobial peptide

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in decreased expression of HAMP mRNA]

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hydroxyacid oxidase 2

decreases expression

ISO

Tamoxifen results in decreased expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

hyaluronan and proteoglycan link protein 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of HAPLN1 mRNA
Tamoxifen results in increased expression of HAPLN1 mRNA

PMID:14699072 PMID:25123088

NCBI chr 2:22,366,967...22,431,709
Ensembl chr 2:22,366,967...22,429,098

G

histidyl-tRNA synthetase 1

affects expression

ISO

Tamoxifen affects the expression of HARS1 mRNA

NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,655,671...28,672,712

G

hyaluronan synthase 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA

NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535

G

histone acetyltransferase 1

affects expression

ISO

Tamoxifen affects the expression of HAT1 mRNA

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

HAUS augmin-like complex, subunit 1

affects expression

ISO

Tamoxifen affects the expression of HAUS1 mRNA

NCBI chr18:73,550,549...73,561,757
Ensembl chr18:73,548,669...73,565,761

G

hemoglobin alpha, adult chain 1

affects expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of HBA-A1 mRNA
Tamoxifen results in decreased expression of HBA-A1 mRNA

PMID:17555576 PMID:19400957

NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,841,763...15,842,603

G

hemoglobin, beta adult minor chain

affects expression

ISO

Tamoxifen affects the expression of HBB-B2 mRNA

NCBI chr 1:167,655,583...167,656,963

G

heparin-binding EGF-like growth factor

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of HBEGF mRNA; Tamoxifen inhibits the reaction [EGF protein results in increased expression of HBEGF mRNA]

PMID:19059307 PMID:24758408

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

HBS1-like translational GTPase

affects expression

ISO

Tamoxifen affects the expression of HBS1L mRNA

NCBI chr 1:17,912,139...17,989,651
Ensembl chr 1:17,912,070...17,989,646

G

hypocretin receptor 2

decreases expression

ISO

Tamoxifen results in decreased expression of HCRTR2 mRNA

NCBI chr 8:85,870,279...85,986,405
Ensembl chr 8:85,870,279...85,986,405

G

histone deacetylase 1

multiple interactions

ISO

Tamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter]

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

histone deacetylase 2

multiple interactions
affects expression

ISO

Tamoxifen promotes the reaction [HDAC2 protein binds to FOXM1 promoter]
Tamoxifen affects the expression of HDAC2 mRNA

PMID:17555576 PMID:20208560

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311

G

histone deacetylase 4

multiple interactions

ISO

HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]

NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637

G

histone deacetylase 6

affects expression

ISO

Tamoxifen affects the expression of HDAC6 mRNA

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

HD domain containing 3

affects expression

ISO

Tamoxifen affects the expression of HDDC3 mRNA

NCBI chr 1:143,708,703...143,711,010
Ensembl chr 1:143,705,320...143,711,010

G

haloacid dehalogenase-like hydrolase domain containing 2

decreases expression

ISO

Tamoxifen results in decreased expression of HDHD2 mRNA

NCBI chr18:72,763,313...72,801,679
Ensembl chr18:72,749,976...72,801,679

G

haloacid dehalogenase-like hydrolase domain containing 3

affects expression

ISO

Tamoxifen affects the expression of HDHD3 mRNA

NCBI chr 5:80,966,878...80,970,345
Ensembl chr 5:80,954,610...80,970,854

G

heart development protein with EGF-like domains 1

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of HEG1 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA

PMID:14699072 PMID:19059307

NCBI chr11:80,512,096...80,600,150
Ensembl chr11:80,512,096...80,600,092

G

DNA helicase B

affects expression

ISO

Tamoxifen affects the expression of HELB mRNA

NCBI chr 7:57,474,115...57,502,221
Ensembl chr 7:57,474,184...57,501,225

G

hephaestin

increases expression

ISO

Tamoxifen results in increased expression of HEPH mRNA

NCBI chr X:65,160,628...65,412,457
Ensembl chr X:65,305,773...65,412,453

G

homocysteine inducible ER protein with ubiquitin like domain 1

affects expression

ISO

Tamoxifen affects the expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

hexosaminidase subunit alpha

affects expression

ISO

Tamoxifen affects the expression of HEXA mRNA

NCBI chr 8:68,832,524...68,857,462
Ensembl chr 8:68,809,615...68,859,560

G

hes-related family bHLH transcription factor with YRPW motif-like

affects expression

ISO

Tamoxifen affects the expression of HEYL mRNA

NCBI chr 5:140,793,271...140,810,262
Ensembl chr 5:140,793,271...140,810,262

G

hepatocyte growth factor

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of HGF mRNA
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of HGF mRNA

PMID:17555576 PMID:29974145

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

heparan-alpha-glucosaminide N-acetyltransferase

affects expression

ISO

Tamoxifen affects the expression of HGSNAT mRNA

NCBI chr16:72,807,967...72,840,180
Ensembl chr16:72,807,849...72,840,176

G

HHIP like 2

decreases expression

ISO

Tamoxifen results in decreased expression of HHIPL2 mRNA

NCBI chr13:97,586,296...97,606,223
Ensembl chr13:97,586,341...97,606,223

G

HIC ZBTB transcriptional repressor 2

affects expression

ISO

Tamoxifen affects the expression of HIC2 mRNA

NCBI chr11:97,241,308...97,294,429
Ensembl chr11:97,240,704...97,271,713

G

hypoxia inducible factor 1 subunit alpha

decreases response to substance

ISO

HIF1A protein results in decreased susceptibility to Tamoxifen

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

HIG1 hypoxia inducible domain family, member 1A

affects expression

ISO

Tamoxifen affects the expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

histidine triad nucleotide binding protein 1

affects expression

ISO

Tamoxifen affects the expression of HINT1 mRNA

NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642

G

huntingtin interacting protein 1

increases expression

ISO

Tamoxifen results in increased expression of HIP1 mRNA

NCBI chr12:26,769,868...26,904,367
Ensembl chr12:26,769,961...26,904,296

G

hexokinase 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HK1 mRNA

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814

G

hydroxymethylbilane synthase

decreases expression

ISO

Tamoxifen results in decreased expression of HMBS mRNA

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

G

high mobility group 20A

affects expression

ISO

Tamoxifen affects the expression of HMG20A mRNA

NCBI chr 8:65,715,688...65,791,663
Ensembl chr 8:65,715,219...65,791,608

G

high mobility group box 2

affects expression

ISO

Tamoxifen affects the expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

3-hydroxy-3-methylglutaryl-CoA reductase

affects expression
increases expression
multiple interactions

ISO

Tamoxifen affects the expression of HMGCR mRNA
Tamoxifen results in increased expression of HMGCR mRNA; Tamoxifen results in increased expression of HMGCR protein
fatostatin inhibits the reaction [Tamoxifen results in increased expression of HMGCR mRNA]; fatostatin inhibits the reaction [Tamoxifen results in increased expression of HMGCR protein]

PMID:20937368 PMID:35944649

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

affects expression

ISO

Tamoxifen affects the expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression
affects expression

ISO

Tamoxifen results in decreased expression of HMGCS2 mRNA
Tamoxifen affects the expression of HMGCS2 mRNA

PMID:17555576 PMID:20937368

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

high mobility group nucleosome binding domain 1

affects expression

ISO

Tamoxifen affects the expression of HMGN1 mRNA

NCBI chr11:48,891,813...48,897,732
Ensembl chr11:48,891,814...48,897,771

G

heme oxygenase 1

multiple interactions
increases expression
decreases expression
affects expression

ISO
EXP

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA
Tamoxifen results in increased expression of HMOX1 mRNA
Tamoxifen results in decreased expression of HMOX1 mRNA
Tamoxifen affects the expression of HMOX1 mRNA

PMID:16298037 PMID:17555576 PMID:19059307 PMID:19224547

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hepatocyte nuclear factor 4, alpha

affects expression
decreases activity

ISO

Tamoxifen affects the expression of HNF4A mRNA
Tamoxifen results in decreased activity of HNF4A protein

PMID:17555576 PMID:20937368

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

heterogeneous nuclear ribonucleoprotein A3

affects expression

ISO

Tamoxifen affects the expression of HNRNPA3 mRNA

NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:80,985,969...80,996,043

G

heterogeneous nuclear ribonucleoprotein A/B

decreases expression
increases expression
affects expression
multiple interactions

ISO
EXP

Tamoxifen results in decreased expression of HNRNPAB protein
Tamoxifen results in increased expression of HNRNPAB mRNA
Tamoxifen affects the expression of HNRNPAB mRNA
[Tretinoin co-treated with Tamoxifen] results in decreased expression of HNRNPAB protein

PMID:17098229 PMID:17555576 PMID:19400957

NCBI chr10:36,358,004...36,363,898
Ensembl chr10:36,358,006...36,364,307

G

heterogeneous nuclear ribonucleoprotein H1

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of HNRNPH1 protein
[Tretinoin co-treated with Tamoxifen] results in increased expression of HNRNPH1 protein

NCBI chr10:35,187,412...35,203,909
Ensembl chr10:35,193,890...35,203,906

G

heterogeneous nuclear ribonucleoprotein H2

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of HNRNPH2 protein
[Tretinoin co-treated with Tamoxifen] results in increased expression of HNRNPH2 protein

NCBI chr X:102,074,175...102,080,115
Ensembl chr X:102,074,179...102,081,025

G

heterogeneous nuclear ribonucleoprotein H3

decreases expression
multiple interactions

ISO

Tamoxifen results in decreased expression of HNRNPH3 protein
[Tretinoin co-treated with Tamoxifen] results in decreased expression of HNRNPH3 protein

NCBI chr20:25,619,540...25,624,397
Ensembl chr20:25,615,577...25,625,162

G

heterogeneous nuclear ribonucleoprotein L

affects expression

ISO

Tamoxifen affects the expression of HNRNPL mRNA

NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061

G

heterogeneous nuclear ribonucleoprotein U

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of HNRNPU mRNA
Tamoxifen results in increased expression of HNRNPU mRNA

PMID:14699072 PMID:17555576 PMID:19400957

NCBI chr13:92,609,791...92,618,580
Ensembl chr13:92,605,216...92,618,612

G

homer scaffold protein 2

affects expression
decreases expression

ISO

Tamoxifen affects the expression of HOMER2 mRNA
Tamoxifen results in decreased expression of HOMER2 mRNA

PMID:14699072 PMID:15590111

NCBI chr 1:144,968,207...145,069,022
Ensembl chr 1:144,976,436...145,068,997

G

HOP homeobox

increases expression

ISO

Tamoxifen results in increased expression of HOPX mRNA

NCBI chr14:31,410,235...31,437,189
Ensembl chr14:31,410,221...31,437,188

G

homeobox D8

affects expression

ISO

Tamoxifen affects the expression of HOXD8 mRNA

NCBI chr 3:80,015,223...80,017,789
Ensembl chr 3:80,014,735...80,018,765

G

hippocalcin-like 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

hepsin

increases expression

ISO

Tamoxifen results in increased expression of HPN mRNA

NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199

G

hypoxanthine phosphoribosyltransferase 1

affects expression

ISO

Tamoxifen affects the expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

hemopexin

affects expression

ISO

Tamoxifen affects the expression of HPX mRNA

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

HR, lysine demethylase and nuclear receptor corepressor

increases expression

ISO

Tamoxifen results in increased expression of HR mRNA

NCBI chr15:52,036,540...52,056,019
Ensembl chr15:52,036,540...52,056,015

G

histidine-rich glycoprotein

decreases response to substance

ISO

HRG protein results in decreased susceptibility to Tamoxifen

NCBI chr11:91,559,087...91,573,982
Ensembl chr11:91,559,091...91,573,982

G

harakiri, BCL2 interacting protein

affects expression

ISO

Tamoxifen affects the expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561

G

heparan sulfate 6-O-sulfotransferase 1

affects expression

ISO

Tamoxifen affects the expression of HS6ST1 mRNA

NCBI chr 9:45,779,402...45,818,583
Ensembl chr 9:45,779,019...45,818,582

G

heat shock factor binding protein 1-like 1

decreases expression

ISO

Tamoxifen results in decreased expression of HSBP1L1 mRNA

NCBI chr18:75,957,266...75,963,024
Ensembl chr18:75,957,266...75,963,024

G

hydroxysteroid (17-beta) dehydrogenase 2

affects expression

ISO

Tamoxifen affects the expression of HSD17B2 mRNA

NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943

G

hydroxysteroid (17-beta) dehydrogenase 3

affects expression

ISO

Tamoxifen affects the expression of HSD17B3 mRNA

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

heat shock protein 90 alpha family class A member 1

increases expression
affects expression

ISO
EXP

Tamoxifen results in increased expression of HSP90AA1 mRNA
Tamoxifen affects the expression of HSP90AA1 mRNA

PMID:17555576 PMID:19400957 PMID:20937368

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

affects expression

ISO

Tamoxifen affects the expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein 90 beta family member 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of HSP90B1 mRNA
Tamoxifen results in increased expression of HSP90B1 protein

PMID:12460799 PMID:17555576

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 13

increases expression

ISO

Tamoxifen results in increased expression of HSPA13 mRNA

NCBI chr11:27,862,717...27,876,898
Ensembl chr11:27,862,593...27,876,898

G

heat shock protein family A (Hsp70) member 1A

affects expression
increases expression

ISO

Tamoxifen affects the expression of HSPA1A mRNA
Tamoxifen results in increased expression of HSPA1A mRNA; Tamoxifen results in increased expression of HSPA1A protein

PMID:12460799 PMID:20937368 PMID:25123088

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

affects expression

ISO

Tamoxifen affects the expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1 like

affects expression

ISO

Tamoxifen affects the expression of HSPA1L mRNA

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

heat shock protein family A (Hsp70) member 2

affects expression
increases expression

ISO

Tamoxifen affects the expression of HSPA2 mRNA
Tamoxifen results in increased expression of HSPA2 mRNA

PMID:20937368 PMID:25123088

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

heat shock protein family A (Hsp70) member 4

affects expression

ISO

Tamoxifen affects the expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 4 like

affects expression

ISO

Tamoxifen affects the expression of HSPA4L mRNA

PMID:17555576 PMID:20937368

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:125,668,236...125,720,986

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression
affects expression

ISO
EXP

Tamoxifen promotes the reaction [Nelfinavir results in increased expression of HSPA5 protein]
Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein]; Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]
Tamoxifen results in increased expression of HSPA5 mRNA
Tamoxifen affects the expression of HSPA5 mRNA
Tamoxifen results in increased expression of HSPA5 protein

PMID:17555576 PMID:19400957 PMID:19812351 PMID:20594311 PMID:23038002

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 8

affects expression

ISO

Tamoxifen affects the expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family B (small) member 1

multiple interactions
affects expression

ISO

[Tamoxifen binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA
Tamoxifen affects the expression of HSPB1 mRNA

PMID:11174852 PMID:20937368

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family B (small) member 3

affects expression

ISO

Tamoxifen affects the expression of HSPB3 mRNA

NCBI chr 2:47,028,451...47,029,165
Ensembl chr 2:47,024,757...47,029,373

G

heat shock protein family B (small) member 8

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA
Tamoxifen affects the expression of HSPB8 mRNA

PMID:19059307 PMID:20937368

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

heat shock protein family D (Hsp60) member 1

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of HSPD1 mRNA
Tamoxifen results in increased expression of HSPD1 mRNA

PMID:17555576 PMID:19400957

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family E (Hsp10) member 1

increases expression
affects expression

EXP
ISO

Tamoxifen results in increased expression of HSPE1 mRNA
Tamoxifen affects the expression of HSPE1 mRNA

PMID:17555576 PMID:19400957

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

heat shock protein family H (Hsp110) member 1

affects expression

ISO

Tamoxifen affects the expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

5-hydroxytryptamine receptor 1D

increases expression

ISO

Tamoxifen results in increased expression of HTR1D mRNA

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

G

5-hydroxytryptamine receptor 2A

affects expression

ISO

Tamoxifen affects the expression of HTR2A mRNA

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 3A

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA
Tamoxifen affects the expression of HTR3A mRNA

PMID:14699072 PMID:19059307

NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884

G

5-hydroxytryptamine receptor 7

decreases expression

ISO

Tamoxifen results in decreased expression of HTR7 mRNA

NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230

G

HtrA serine peptidase 1

increases expression

ISO

Tamoxifen results in increased expression of HTRA1 mRNA

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:194,927,687...194,977,620

G

hyaluronidase 2

affects expression

ISO

Tamoxifen affects the expression of HYAL2 mRNA

NCBI chr 8:117,121,802...117,125,494
Ensembl chr 8:117,121,787...117,125,493

G

hyccin PI4KA lipid kinase complex subunit 1

affects expression

ISO

Tamoxifen affects the expression of HYCC1 mRNA

NCBI chr 4:12,024,692...12,131,504
Ensembl chr 4:12,024,739...12,131,501

G

hydroxypyruvate isomerase

affects expression

ISO

Tamoxifen affects the expression of HYI mRNA

NCBI chr 5:137,179,975...137,182,654
Ensembl chr 5:137,179,976...137,182,654

G

integrin-binding sialoprotein

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of BSP mRNA

NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299

G

isoprenylcysteine carboxyl methyltransferase

affects expression

ISO

Tamoxifen affects the expression of ICMT mRNA

NCBI chr 5:168,084,487...168,097,519
Ensembl chr 5:168,086,057...168,093,094

G

inducible T-cell co-stimulator ligand

affects expression
increases expression

ISO

Tamoxifen affects the expression of ICOSL mRNA
Tamoxifen results in increased expression of ICOSL mRNA

PMID:17555576 PMID:25123088

NCBI chr20:10,600,078...10,610,385
Ensembl chr20:10,600,078...10,610,365

G

inhibitor of DNA binding 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of ID1 mRNA
Tamoxifen results in increased expression of ID1 mRNA

PMID:14699072 PMID:17555576 PMID:20937368 PMID:25123088

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 2

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ID2 mRNA
[Tamoxifen co-treated with Zearalenone] results in increased expression of ID2 mRNA

PMID:17555576 PMID:20937368 PMID:30138655

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

inhibitor of DNA binding 3

affects expression

ISO

Tamoxifen affects the expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

inhibitor of DNA binding 4

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ID4 mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of ID4 mRNA

PMID:17555576 PMID:19059307 PMID:20937368

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

isocitrate dehydrogenase (NADP(+)) 2

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of IDH2 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of IDH2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Tamoxifen results in decreased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

immediate early response 3

affects expression
increases expression

ISO

Tamoxifen affects the expression of IER3 mRNA
Tamoxifen results in increased expression of IER3 mRNA

PMID:14699072 PMID:15604281

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

immediate early response 3 interacting protein 1

affects expression

ISO

Tamoxifen affects the expression of IER3IP1 mRNA

NCBI chr18:72,749,976...72,761,060
Ensembl chr18:72,749,976...72,801,679

G

interferon, alpha-inducible protein 27

affects expression
increases expression

ISO

Tamoxifen affects the expression of IFI27 mRNA
Tamoxifen results in increased expression of IFI27 mRNA

PMID:19155303 PMID:20937368

NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781

G

IFI30, lysosomal thiol reductase

affects expression

ISO

Tamoxifen affects the expression of IFI30 mRNA

NCBI chr16:18,709,570...18,713,635
Ensembl chr16:18,709,563...18,715,711

G

interferon-induced protein 35

affects expression

ISO

Tamoxifen affects the expression of IFI35 mRNA

NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750

G

interferon-induced protein 44

affects expression

ISO

Tamoxifen affects the expression of IFI44 mRNA

PMID:17555576 PMID:20937368

NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877

G

interferon-induced protein 44-like

increases expression

ISO

Tamoxifen results in increased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404

G

interferon induced with helicase C domain 1

affects expression

ISO

Tamoxifen affects the expression of IFIH1 mRNA

NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968

G

interferon-induced protein with tetratricopeptide repeats 1

decreases expression
affects expression

ISO

Tamoxifen results in decreased expression of IFIT1 mRNA
Tamoxifen affects the expression of IFIT1 mRNA

PMID:20937368 PMID:25123088

NCBI chr 1:241,565,197...241,567,262
Ensembl chr 1:241,543,184...241,568,148

G

interferon-induced protein with tetratricopeptide repeats 2

affects expression

ISO

Tamoxifen affects the expression of IFIT2 mRNA

PMID:14699072 PMID:20937368

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:241,515,709...241,521,798

G

interferon-induced protein with tetratricopeptide repeats 3

affects expression
increases expression

ISO

Tamoxifen affects the expression of IFIT3 mRNA
Tamoxifen results in increased expression of IFIT3 mRNA

PMID:19155303 PMID:20937368

NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521

G

interferon induced transmembrane protein 1

multiple interactions
increases expression

EXP
ISO

[Bexarotene co-treated with Tamoxifen] results in decreased expression of IFITM1 mRNA
Tamoxifen results in increased expression of IFITM1 mRNA

PMID:17630414 PMID:19155303

NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776

G

interferon, alpha 1

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of IFNA1 mRNA
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of IFNA1 mRNA

PMID:19155303 PMID:29974145

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interferon beta 1

multiple interactions

ISO

[IFNB1 protein co-treated with Tamoxifen] results in increased expression of TXNRD1 protein
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of IFNB1 mRNA

PMID:10771088 PMID:29974145

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487

G

interferon gamma

multiple interactions
decreases expression

ISO

[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of IFNG mRNA; Tamoxifen inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]
Tamoxifen results in decreased expression of IFNG mRNA; Tamoxifen results in decreased expression of IFNG protein

PMID:19031437 PMID:19446535 PMID:35468944

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA

NCBI chr11:44,265,703...44,283,975
Ensembl chr11:44,265,703...44,283,975

G

interferon-related developmental regulator 1

affects expression

ISO

Tamoxifen affects the expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

intraflagellar transport 20

affects expression

ISO

Tamoxifen affects the expression of IFT20 mRNA

NCBI chr10:63,930,629...63,936,174
Ensembl chr10:63,930,681...63,936,172

G

intraflagellar transport 56

increases expression

ISO

Tamoxifen results in increased expression of IFT56 mRNA

NCBI chr 4:68,057,530...68,115,494
Ensembl chr 4:68,057,580...68,119,338

G

intraflagellar transport 88

affects expression

ISO

Tamoxifen affects the expression of IFT88 mRNA

NCBI chr15:35,685,678...35,786,875
Ensembl chr15:35,688,927...35,781,634

G

insulin-like growth factor 1

decreases expression
multiple interactions
increases expression
affects expression

ISO
EXP

Tamoxifen results in decreased expression of IGF1 protein
[bicalutamide co-treated with Tamoxifen] results in decreased expression of IGF1 protein; Tamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF1 protein]
Tamoxifen results in increased expression of IGF1 mRNA
Tamoxifen affects the expression of IGF1 mRNA

PMID:15809018 PMID:16847815 PMID:17555576 PMID:19400957 PMID:20332317

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

increases expression

ISO

Tamoxifen results in increased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor 2

multiple interactions
affects expression
decreases secretion

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF2 protein]; Tamoxifen inhibits the reaction [resveratrol results in increased secretion of IGF2 protein]
Tamoxifen affects the expression of IGF2 mRNA
Tamoxifen results in decreased secretion of IGF2 protein

PMID:16037384 PMID:17555576

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

ISO

Tamoxifen results in decreased expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 1

multiple interactions
increases expression
affects expression

ISO

[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP1 protein
Tamoxifen results in increased expression of IGFBP1 mRNA
Tamoxifen affects the expression of IGFBP1 mRNA

PMID:16847815 PMID:20937368 PMID:27089845

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

increases expression
multiple interactions
decreases expression

ISO
EXP

Tamoxifen results in increased expression of IGFBP2 mRNA
[Tamoxifen co-treated with bexarotene] results in increased expression of IGFBP2 mRNA
Tamoxifen results in decreased expression of IGFBP2 mRNA

PMID:17555576 PMID:17630414

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 3

multiple interactions

ISO
EXP

[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP3 protein
[bexarotene co-treated with Tamoxifen] results in decreased expression of IGFBP3 mRNA

PMID:16847815 PMID:17630414

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

insulin-like growth factor binding protein 4

affects expression

ISO

Tamoxifen affects the expression of IGFBP4 mRNA

PMID:14699072 PMID:17555576

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

insulin-like growth factor binding protein 5

affects expression
increases response to substance

ISO

Tamoxifen affects the expression of IGFBP5 mRNA
IGFBP5 protein results in increased susceptibility to Tamoxifen

PMID:14699072 PMID:20354179

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390

G

insulin-like growth factor binding protein 6

affects expression

ISO

Tamoxifen affects the expression of IGFBP6 mRNA

NCBI chr 7:135,154,919...135,159,550
Ensembl chr 7:135,154,685...135,159,795

G

insulin-like growth factor binding protein 7

multiple interactions
increases expression

EXP
ISO

[bexarotene co-treated with Tamoxifen] results in decreased expression of IGFBP7 mRNA
Tamoxifen results in increased expression of IGFBP7 mRNA

PMID:17630414 PMID:25123088

NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620

G

insulin-like growth factor binding protein-like 1

increases expression

ISO

Tamoxifen results in increased expression of IGFBPL1 mRNA

NCBI chr 5:64,872,056...64,887,461
Ensembl chr 5:64,872,057...64,887,461

G

interleukin 12 receptor subunit beta 1

increases expression

ISO

Tamoxifen results in increased expression of IL12RB1 mRNA

NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,654,207...18,666,824

G

interleukin 17 receptor A

affects expression
increases expression

ISO

Tamoxifen affects the expression of IL17RA mRNA
Tamoxifen results in increased expression of IL17RA mRNA

PMID:20937368 PMID:25123088

NCBI chr 4:155,339,742...155,362,382
Ensembl chr 4:155,339,400...155,362,382

G

interleukin 1 beta

decreases expression
multiple interactions
increases expression

ISO
EXP

Tamoxifen results in decreased expression of IL1B mRNA; Tamoxifen results in decreased expression of IL1B protein
Fulvestrant inhibits the reaction [Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]]; Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL1B protein]; zinc chloride inhibits the reaction [Tamoxifen results in increased expression of IL1B protein]
[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein]; Tamoxifen promotes the reaction [resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]]

PMID:15180920 PMID:16298037 PMID:17516992 PMID:19457130 PMID:25305410 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

affects expression

ISO

Tamoxifen affects the expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 2

decreases expression

ISO

Tamoxifen results in decreased expression of IL2 mRNA

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 20

multiple interactions

ISO

Tamoxifen inhibits the reaction [EGF protein results in increased expression of IL20 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of IL20 mRNA]

NCBI chr13:44,933,249...44,936,893
Ensembl chr13:44,933,249...44,936,893

G

interleukin 24

decreases expression

ISO

Tamoxifen results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 2 receptor subunit gamma

affects expression

ISO

Tamoxifen affects the expression of IL2RG mRNA

NCBI chr X:70,435,340...70,439,052
Ensembl chr X:70,435,343...70,439,161

G

interleukin 4

decreases expression
increases expression
affects expression

ISO

Tamoxifen results in decreased expression of IL4 mRNA
Tamoxifen results in increased expression of IL4 mRNA; Tamoxifen results in increased expression of IL4 protein
Tamoxifen affects the expression of IL4 mRNA

PMID:15590111 PMID:17555576 PMID:19031437

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 4 induced 1

affects expression

ISO

Tamoxifen affects the expression of IL4I1 mRNA

NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:104,435,981...104,461,053

G

interleukin 4 receptor

affects expression
increases expression

ISO

Tamoxifen affects the expression of IL4R mRNA
Tamoxifen results in increased expression of IL4RA mRNA

PMID:14699072 PMID:19031437

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 5

affects expression

ISO

Tamoxifen affects the expression of IL5 mRNA

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions
increases expression
decreases activity
decreases expression

ISO
EXP

[Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of IL6 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of IL6 protein]
Tamoxifen results in increased expression of IL6 protein
Tamoxifen inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; zinc chloride inhibits the reaction [Tamoxifen results in increased expression of IL6 protein]
Tamoxifen inhibits the reaction [bisphenol A inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]]; Tamoxifen inhibits the reaction [Estradiol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]]; Tamoxifen inhibits the reaction [Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Tamoxifen inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; Tamoxifen inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; Tamoxifen inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Tamoxifen results in increased expression of IL6 mRNA
Tamoxifen results in decreased activity of IL6 protein
Tamoxifen results in decreased expression of IL6 mRNA; Tamoxifen results in decreased expression of IL6 protein

PMID:8979148 PMID:15604281 PMID:15953991 PMID:16298037 PMID:17516992 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7

decreases expression

ISO

Tamoxifen results in decreased expression of IL7 mRNA

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389

G

integrin-linked kinase

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ILK mRNA
Tamoxifen inhibits the reaction [ESR1 protein binds to ILK protein]

PMID:17555576 PMID:23665804

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

inhibitor of growth family, member 1

affects expression

ISO

Tamoxifen affects the expression of ING1 mRNA

NCBI chr16:84,639,378...84,649,498
Ensembl chr16:84,639,381...84,647,616

G

inhibitor of growth family, member 4

affects expression

ISO

Tamoxifen affects the expression of ING4 mRNA

NCBI chr 4:159,528,183...159,536,762
Ensembl chr 4:159,528,189...159,536,761

G

inhibin subunit beta A

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of INHBA mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of INHBA mRNA

PMID:17555576 PMID:19059307

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

inhibin subunit beta B

affects expression
increases expression

ISO

Tamoxifen affects the expression of INHBB mRNA
Tamoxifen results in increased expression of INHBB mRNA

PMID:17555576 PMID:20937368

NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609

G

inhibin subunit beta E

affects expression
increases expression

ISO

Tamoxifen affects the expression of INHBE mRNA
Tamoxifen results in increased expression of INHBE mRNA

PMID:17175557 PMID:17567588 PMID:20937368

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

indolethylamine N-methyltransferase

increases expression

ISO

Tamoxifen results in increased expression of INMT mRNA

NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:85,648,459...85,652,755

G

inositol polyphosphate-5-phosphatase A

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA
Tamoxifen affects the expression of INPP5A mRNA

PMID:17555576 PMID:19059307

NCBI chr 1:203,619,676...203,810,035
Ensembl chr 1:203,619,637...203,810,028

G

inositol polyphosphate-5-phosphatase K

affects expression

ISO

Tamoxifen affects the expression of PPS mRNA

NCBI chr10:60,974,183...60,995,047
Ensembl chr10:60,973,950...60,995,046

G

insulin induced gene 2

affects expression

ISO

Tamoxifen affects the expression of INSIG2 mRNA

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

insulin-like 3

affects expression

ISO

Tamoxifen affects the expression of INSL3 mRNA

NCBI chr16:18,432,668...18,434,539

G

insulin-like 6

affects expression

ISO

Tamoxifen affects the expression of INSL6 mRNA

NCBI chr 1:236,483,530...236,487,065
Ensembl chr 1:236,483,530...236,487,065

G

integrator complex subunit 6

affects expression

ISO

Tamoxifen affects the expression of INTS6 mRNA

NCBI chr15:41,080,584...41,224,350
Ensembl chr15:41,109,125...41,197,519

G

integrator complex subunit 6 like

affects expression

ISO

Tamoxifen affects the expression of INTS6L mRNA

NCBI chr X:139,295,490...139,363,090
Ensembl chr X:139,295,512...139,359,161

G

inturned planar cell polarity protein

increases expression

ISO

Tamoxifen results in increased expression of INTU mRNA

NCBI chr 2:125,528,965...125,613,295
Ensembl chr 2:125,529,208...125,613,295

G

importin 4

affects expression

ISO

Tamoxifen affects the expression of IPO4 mRNA

NCBI chr15:33,087,321...33,097,241
Ensembl chr15:33,087,321...33,097,241

G

inositol 1,4,5-triphosphate receptor associated 2

affects expression

ISO

Tamoxifen affects the expression of IRAG2 mRNA

NCBI chr 4:179,819,526...179,874,408
Ensembl chr 4:179,820,188...179,874,406

G

interferon regulatory factor 1

affects expression

ISO

Tamoxifen affects the expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

interferon regulatory factor 2 binding protein 2

increases expression

ISO

Tamoxifen results in increased expression of IRF2BP2 mRNA

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368

G

interferon regulatory factor 3

affects expression

ISO

Tamoxifen affects the expression of IRF3 mRNA

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

interferon regulatory factor 5

decreases expression

ISO

Tamoxifen results in decreased expression of IRF5 mRNA

NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552

G

interferon regulatory factor 6

affects expression

ISO

Tamoxifen affects the expression of IRF6 mRNA

NCBI chr13:107,200,876...107,220,083
Ensembl chr13:107,200,731...107,220,049

G

interferon regulatory factor 7

affects expression

ISO

Tamoxifen affects the expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

interferon regulatory factor 9

affects expression

ISO

Tamoxifen affects the expression of IRF9 mRNA

PMID:17555576 PMID:20937368

NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879

G

immunity-related GTPase M

affects expression

ISO

Tamoxifen affects the expression of IRGM mRNA

NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,732,961...33,743,228

G

insulin receptor substrate 1

affects expression

ISO

Tamoxifen affects the expression of IRS1 mRNA

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

insulin receptor substrate 3

multiple interactions
increases expression

EXP

[Tamoxifen co-treated with Bexarotene] results in increased expression of IRS3 mRNA
Tamoxifen results in increased expression of IRS3 mRNA

NCBI chr12:24,689,930...24,692,068
Ensembl chr12:24,689,909...24,692,068

G

iroquois homeobox 3

affects expression

ISO

Tamoxifen affects the expression of IRX3 mRNA

NCBI chr19:31,384,803...31,388,241
Ensembl chr19:31,384,833...31,388,238

G

interferon stimulated exonuclease gene 20

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ISG20 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of ISG20 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401

G

immunoglobulin superfamily containing leucine-rich repeat

affects expression

ISO

Tamoxifen affects the expression of ISLR mRNA

NCBI chr 8:67,467,013...67,469,989
Ensembl chr 8:67,444,536...67,487,493

G

ISY1 splicing factor homolog

affects expression

ISO

Tamoxifen affects the expression of ISY1 mRNA

NCBI chr 4:121,833,870...121,854,561
Ensembl chr 4:121,806,992...121,854,561

G

inositol-3-phosphate synthase 1

increases expression

ISO

Tamoxifen results in increased expression of ISYNA1 mRNA

NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,873,121...18,875,955

G

integrin subunit alpha 5

decreases expression

ISO

Tamoxifen results in decreased expression of ITGA5 mRNA

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305

G

integrin subunit alpha 6

affects expression

ISO

Tamoxifen affects the expression of ITGA6 mRNA

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

integrin subunit alpha 9

decreases expression

ISO

Tamoxifen results in decreased expression of ITGA9 mRNA

NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:127,169,226...127,493,296

G

integrin subunit alpha M

decreases expression

ISO

Tamoxifen results in decreased expression of ITGAM protein

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit alpha X

decreases expression

ISO

Tamoxifen results in decreased expression of ITGAX protein

NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151

G

integrin subunit beta 1

increases expression

ISO

Tamoxifen results in increased expression of ITGB1 mRNA

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 3

affects expression

ISO

Tamoxifen affects the expression of ITGB3 mRNA

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

integrin subunit beta 5

affects expression

ISO

Tamoxifen affects the expression of ITGB5 mRNA

NCBI chr11:80,333,588...80,449,373
Ensembl chr11:80,333,590...80,449,373

G

integrin subunit beta 7

affects expression

ISO

Tamoxifen affects the expression of ITGB7 mRNA

NCBI chr 7:135,225,962...135,243,522
Ensembl chr 7:135,226,555...135,243,597

G

inter-alpha trypsin inhibitor, heavy chain 3

affects expression

ISO

Tamoxifen affects the expression of ITIH3 mRNA

NCBI chr16:6,108,378...6,123,609
Ensembl chr16:6,108,382...6,123,374

G

inter-alpha-trypsin inhibitor heavy chain 5

affects expression

ISO

Tamoxifen affects the expression of ITIH5 mRNA

NCBI chr17:73,161,886...73,261,930
Ensembl chr17:73,161,611...73,262,496

G

integral membrane protein 2B

affects expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of ITM2B mRNA
Tamoxifen results in decreased expression of ITM2B mRNA

PMID:14699072 PMID:17555576 PMID:19400957

NCBI chr15:54,955,549...54,978,455
Ensembl chr15:54,955,552...54,978,455

G

inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions
affects expression
increases expression

ISO

Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA]
Tamoxifen affects the expression of ITPR1 mRNA
Tamoxifen results in increased expression of ITPR1 mRNA

PMID:17555576 PMID:19426747

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

inositol 1,4,5-trisphosphate receptor, type 3

affects expression

ISO

Tamoxifen affects the expression of ITPR3 mRNA

NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184

G

involucrin

multiple interactions
decreases expression
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of IVL mRNA; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of IVL mRNA]
Tamoxifen affects the expression of IVL mRNA

PMID:14699072 PMID:15590111 PMID:19059307

NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578

G

influenza virus NS1A binding protein

affects expression
increases expression

ISO

Tamoxifen affects the expression of IVNS1ABP mRNA
Tamoxifen results in increased expression of IVNS1ABP mRNA

PMID:17555576 PMID:25123088

NCBI chr13:65,977,069...65,996,685
Ensembl chr13:65,977,045...65,997,547

G

iodotyrosine deiodinase

multiple interactions

ISO

Tamoxifen inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:42,410,130...42,426,386

G

jagged canonical Notch ligand 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872

G

jagunal homolog 1

affects expression

ISO

Tamoxifen affects the expression of JAGN1 mRNA

NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:148,147,229...148,151,915

G

Janus kinase 1

affects expression

ISO

Tamoxifen affects the expression of JAK1 mRNA

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 3

increases expression

ISO

Tamoxifen results in increased expression of JAK3 mRNA

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222

G

junctional adhesion molecule 2

affects expression

ISO

Tamoxifen affects the expression of JAM2 mRNA

NCBI chr11:37,316,287...37,366,517
Ensembl chr11:37,317,511...37,367,510

G

junctional adhesion molecule 3

decreases expression

ISO

Tamoxifen results in decreased expression of JAM3 mRNA

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

junctophilin 3

increases expression

ISO

Tamoxifen results in increased expression of JPH3 mRNA

NCBI chr19:66,702,497...66,763,948
Ensembl chr19:66,702,680...66,763,937

G

Jupiter microtubule associated homolog 1

affects expression

ISO

Tamoxifen affects the expression of JPT1 mRNA

NCBI chr10:101,243,428...101,261,464
Ensembl chr10:101,243,424...101,261,469

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression
affects expression
increases phosphorylation
decreases response to substance

ISO
EXP

[JUN protein results in increased expression of VEGFA protein] which results in decreased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of JUN protein]; JUN protein inhibits the reaction [MAPK12 mutant form results in decreased susceptibility to Tamoxifen]; Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [ESR2 protein binds to [[FOS protein binds to JUN protein] which binds to PTPRO promoter]]
Tamoxifen results in increased expression of JUN protein modified form
Tamoxifen results in decreased expression of JUN protein modified form
[BCL2 co-treated with Tamoxifen] results in increased phosphorylation of JUN protein
Tamoxifen affects the expression of JUN mRNA
JUN protein results in decreased susceptibility to Tamoxifen

PMID:14645110 PMID:15606891 PMID:17555576 PMID:17901229 PMID:19095770 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression
affects expression

ISO

Tamoxifen results in increased expression of JUNB mRNA
Tamoxifen affects the expression of JUNB mRNA

PMID:17555576 PMID:19031437 PMID:20937368

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

affects expression

ISO

Tamoxifen affects the expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

KN motif and ankyrin repeat domains 3

affects expression

ISO

Tamoxifen affects the expression of KANK3 mRNA

NCBI chr 7:15,296,538...15,309,838
Ensembl chr 7:15,296,585...15,311,408

G

lysyl-tRNA synthetase 1

affects expression

ISO

Tamoxifen affects the expression of KARS1 mRNA

NCBI chr19:56,867,096...56,886,151
Ensembl chr19:56,867,096...56,886,073

G

kazrin, periplakin interacting protein

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of KAZN mRNA

NCBI chr 5:159,675,803...160,666,084
Ensembl chr 5:159,675,803...160,664,154

G

kelch repeat and BTB domain containing 12

decreases expression

ISO

Tamoxifen results in decreased expression of KBTBD12 mRNA

NCBI chr 4:122,571,903...122,645,895
Ensembl chr 4:122,573,526...122,645,810

G

potassium voltage-gated channel subfamily A member 3

decreases activity
multiple interactions

ISO

Tamoxifen results in decreased activity of KCNA3 protein
[Tamoxifen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

PMID:17638537 PMID:21362439

NCBI chr 2:197,320,324...197,322,277
Ensembl chr 2:197,318,134...197,350,739

G

potassium voltage-gated channel subfamily A member 5

decreases expression

ISO

Tamoxifen results in decreased expression of KCNA5 mRNA

NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408

G

potassium voltage-gated channel subfamily A regulatory beta subunit 3

increases expression

ISO

Tamoxifen results in increased expression of KCNAB3 mRNA

NCBI chr10:54,546,638...54,555,209
Ensembl chr10:54,546,618...54,553,357

G

potassium voltage-gated channel subfamily D member 3

decreases activity

EXP

Tamoxifen results in decreased activity of KCND3 protein

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium voltage-gated channel subfamily H member 1

multiple interactions

ISO

[Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA; [Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA

NCBI chr13:106,253,101...106,555,712
Ensembl chr13:106,253,213...106,555,710

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity
affects expression

ISO

[Tamoxifen results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Tamoxifen binds to and results in decreased activity of KCNH2 protein; Tamoxifen inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Tamoxifen affects the expression of KCNH2 mRNA

PMID:15272206 PMID:17555576 PMID:19583963 PMID:21158687 PMID:21362439 More...

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium inwardly-rectifying channel, subfamily J, member 1

increases expression

ISO

Tamoxifen results in increased expression of KCNJ1 mRNA

NCBI chr 8:39,014,822...39,066,716
Ensembl chr 8:39,037,992...39,066,715

G

potassium inwardly-rectifying channel, subfamily J, member 8

affects expression

ISO

Tamoxifen affects the expression of KCNJ8 mRNA

PMID:14699072 PMID:17555576

NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:177,239,908...177,246,531

G

potassium two pore domain channel subfamily K member 5

affects expression
decreases expression

ISO

Tamoxifen affects the expression of KCNK5 mRNA
Tamoxifen results in decreased expression of KCNK5 mRNA

PMID:20937368 PMID:25123088

NCBI chr15:4,171,625...4,213,896
Ensembl chr15:4,171,610...4,213,897

G

potassium calcium-activated channel subfamily M alpha 1

multiple interactions

ISO
EXP

Tamoxifen inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; Tamoxifen inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]
[bexarotene co-treated with Tamoxifen] results in decreased expression of KCNMA1 mRNA

PMID:17630414 PMID:21413024

NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117

G

potassium calcium-activated channel subfamily M regulatory beta subunit 1

multiple interactions

ISO

Tamoxifen binds to and results in increased activity of KCNMB1 protein; Tamoxifen inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; Tamoxifen inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]

NCBI chr10:19,062,014...19,119,005
Ensembl chr10:19,062,291...19,073,204

G

potassium calcium-activated channel subfamily N member 4

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of KCNN4 mRNA
[Tamoxifen co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275

G

potassium sodium-activated channel subfamily T member 1

increases expression

ISO

Tamoxifen results in increased expression of KCNT1 mRNA

NCBI chr 3:29,081,071...29,136,902
Ensembl chr 3:29,081,321...29,134,768

G

potassium channel tetramerization domain containing 12

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

KDEL endoplasmic reticulum protein retention receptor 2

affects expression

ISO

Tamoxifen affects the expression of KDELR2 mRNA

NCBI chr12:16,252,424...16,270,737
Ensembl chr12:16,252,424...16,270,719

G

KDEL endoplasmic reticulum protein retention receptor 3

affects expression

ISO

Tamoxifen affects the expression of KDELR3 mRNA

NCBI chr 7:112,959,632...112,969,858
Ensembl chr 7:112,959,718...112,969,858

G

lysine demethylase 5A

increases expression

ISO

Tamoxifen results in increased expression of KDM5A mRNA

NCBI chr 4:155,238,124...155,316,121
Ensembl chr 4:155,238,044...155,316,121

G

lysine demethylase 5B

affects expression

ISO

Tamoxifen affects the expression of KDM5B mRNA

NCBI chr13:48,554,367...48,625,721
Ensembl chr13:48,554,420...48,626,423

G

KH RNA binding domain containing, signal transduction associated 3

affects expression

ISO

Tamoxifen affects the expression of KHDRBS3 mRNA

NCBI chr 7:102,726,628...102,884,545
Ensembl chr 7:102,726,843...102,884,541

G

KH and NYN domain containing

increases expression

ISO

Tamoxifen results in increased expression of SDR39U1 mRNA

NCBI chr15:33,335,290...33,349,553
Ensembl chr15:33,335,274...33,349,552

G

kinesin family member 22

decreases expression

ISO

Tamoxifen results in decreased expression of KIF22 mRNA

NCBI chr 1:191,065,875...191,080,955
Ensembl chr 1:191,065,875...191,080,878

G

kinesin family member 23

increases expression
affects expression

ISO

Tamoxifen results in increased expression of KIF23 mRNA
Tamoxifen affects the expression of KIF23 mRNA

PMID:15590111 PMID:17555576

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

kinesin family member 3a

decreases expression

ISO

Tamoxifen results in decreased expression of KIF3A mRNA

NCBI chr10:38,226,388...38,263,062
Ensembl chr10:38,226,741...38,260,516

G

kinesin family member 3C

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA

NCBI chr 6:32,086,879...32,125,812
Ensembl chr 6:32,086,124...32,126,066

G

kinesin family member 4A

affects expression

ISO

Tamoxifen affects the expression of KIF4 mRNA

NCBI chr X:69,761,803...69,864,335
Ensembl chr X:69,761,883...69,864,335

G

kinesin family member 5B

affects expression

ISO

Tamoxifen affects the expression of KIF5B mRNA

NCBI chr17:56,185,386...56,222,990
Ensembl chr17:56,185,380...56,223,008

G

kinesin family member 9

increases expression

ISO

Tamoxifen results in increased expression of KIF9 mRNA

NCBI chr 8:119,338,014...119,406,632
Ensembl chr 8:119,338,088...119,383,137

G

kinesin family binding protein

affects expression

ISO

Tamoxifen affects the expression of KIFBP mRNA

NCBI chr20:31,055,625...31,075,232
Ensembl chr20:31,055,626...31,075,201

G

KiSS-1 metastasis-suppressor

increases expression
decreases expression

ISO
EXP

Tamoxifen results in increased expression of KISS1 mRNA
Tamoxifen results in decreased expression of KISS1 mRNA

PMID:25123088 PMID:27395752

NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906

G

KLF transcription factor 10

affects expression

ISO

Tamoxifen affects the expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

KLF transcription factor 7

affects expression

ISO

Tamoxifen affects the expression of KLF7 mRNA

NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:72,933,136...73,020,056

G

KLF transcription factor 9

affects expression

ISO

Tamoxifen affects the expression of KLF9 mRNA

NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641

G

kelch domain containing 2

affects expression

ISO

Tamoxifen affects the expression of KLHDC2 mRNA

NCBI chr 6:93,512,981...93,552,809
Ensembl chr 6:93,513,017...93,577,762

G

kelch-like family member 10

affects expression

ISO

Tamoxifen affects the expression of KLHL10 mRNA

NCBI chr10:85,876,804...85,893,081
Ensembl chr10:85,876,783...85,893,081

G

kallikrein 1-related peptidase B3

affects expression

ISO

Tamoxifen affects the expression of KLK1B3 mRNA

NCBI chr 1:103,845,647...103,849,854
Ensembl chr 1:103,845,603...103,849,855

G

kallikrein related-peptidase 8

affects expression

ISO

Tamoxifen affects the expression of KLK8 mRNA

NCBI chr 1:103,388,352...103,395,195
Ensembl chr 1:103,388,352...103,395,195

G

kallikrein related-peptidase 9

affects expression

ISO

Tamoxifen affects the expression of KLK9 mRNA

NCBI chr 1:103,382,888...103,387,180
Ensembl chr 1:103,382,888...103,387,180

G

kallikrein B1

affects expression

ISO

Tamoxifen affects the expression of KLKB1 mRNA

PMID:14699072 PMID:17555576

NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339

G

killer cell lectin like receptor C1

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of KLRC1 mRNA
[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of KLRC1 mRNA

PMID:17962382 PMID:35468944

NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:164,828,163...164,838,464

G

killer cell lectin like receptor C2

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA

NCBI chr 4:164,808,722...164,819,865
Ensembl chr 4:164,808,722...164,819,865

G

killer cell lectin like receptor C3

multiple interactions
affects expression
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; ESR1 protein affects the reaction [Tamoxifen results in increased expression of KLRC3 mRNA]; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of KLRC3 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Tamoxifen promotes the reaction [ESR1 protein binds to KLRC3 gene]; Tamoxifen promotes the reaction [NCOA2 protein binds to KLRC3 gene]; Tamoxifen promotes the reaction [NCOA3 protein binds to KLRC3 gene]
Tamoxifen affects the expression of KLRC3 mRNA

PMID:14699072 PMID:17395694 PMID:19059307

NCBI chr 4:164,791,102...164,798,758
Ensembl chr 4:164,791,128...164,798,758

G

killer cell lectin like receptor D1

multiple interactions

ISO

[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of KLRD1 mRNA

NCBI chr 4:164,730,833...164,742,539
Ensembl chr 4:164,730,856...164,742,538

G

killer cell lectin like receptor K1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA

NCBI chr 4:164,767,377...164,778,453
Ensembl chr 4:164,767,946...164,778,382

G

lysine methyltransferase 5C

decreases expression

ISO

Tamoxifen results in decreased expression of KMT5C mRNA

NCBI chr 1:78,128,325...78,135,931
Ensembl chr 1:78,128,325...78,135,931

G

keratin 1

affects expression

ISO

Tamoxifen affects the expression of KRT1 mRNA

NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537

G

keratin 13

increases expression

EXP
ISO

Tamoxifen results in increased expression of KRT13 mRNA

NCBI chr10:85,552,287...85,556,499
Ensembl chr10:85,552,287...85,556,499

G

keratin 17

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of KRT17 mRNA
Tamoxifen affects the expression of KRT17 mRNA

PMID:17555576 PMID:19059307

NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,679,070...85,683,787

G

keratin 19

affects expression

ISO

Tamoxifen affects the expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

keratin 23

increases expression

ISO

Tamoxifen results in increased expression of KRT23 mRNA

NCBI chr10:84,930,603...84,946,929
Ensembl chr10:84,930,603...84,946,929

G

keratin 34

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of KRT34 mRNA

NCBI chr10:85,470,391...85,474,501
Ensembl chr10:85,470,391...85,474,501

G

keratin 4

increases expression

ISO

Tamoxifen results in increased expression of KRT4 mRNA

NCBI chr 7:134,924,753...134,931,050
Ensembl chr 7:134,924,753...134,930,713

G

keratin 5

affects expression

ISO

Tamoxifen affects the expression of KRT5 mRNA

NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569

G

keratin 7

affects expression

ISO

Tamoxifen affects the expression of KRT7 mRNA

NCBI chr 7:134,407,626...134,423,787
Ensembl chr 7:134,407,584...134,423,786

G

keratin 79

increases expression

ISO

Tamoxifen results in increased expression of KRT79 mRNA

NCBI chr 7:134,935,395...134,946,447
Ensembl chr 7:134,935,396...134,947,286

G

keratin 8

increases expression

ISO
EXP

Tamoxifen results in increased expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

keratin 86

decreases expression

ISO

Tamoxifen results in decreased expression of KRT86 mRNA

NCBI chr 7:134,470,224...134,476,873
Ensembl chr 7:134,470,224...134,476,873

G

keratinocyte associated protein 3

affects expression

ISO

Tamoxifen affects the expression of KRTCAP3 mRNA

NCBI chr 6:30,840,906...30,842,500
Ensembl chr 6:30,840,906...30,842,475

G

kynurenine aminotransferase 3

affects expression

ISO

Tamoxifen affects the expression of KYAT3 mRNA

NCBI chr 2:234,362,306...234,407,646
Ensembl chr 2:234,362,322...234,407,878

G

kynureninase

increases expression

ISO

Tamoxifen results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

L3MBTL histone methyl-lysine binding protein 1

decreases expression

ISO

Tamoxifen results in decreased expression of L3MBTL1 mRNA

NCBI chr 3:172,014,774...172,053,181
Ensembl chr 3:172,021,416...172,053,181

G

laminin subunit alpha 3

affects expression

ISO

Tamoxifen affects the expression of LAMA3 mRNA

NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449

G

laminin subunit alpha 5

affects expression

ISO

Tamoxifen affects the expression of LAMA5 mRNA

NCBI chr 3:187,647,904...187,695,974
Ensembl chr 3:187,647,904...187,696,173

G

laminin subunit beta 3

decreases expression

ISO

Tamoxifen results in decreased expression of LAMB3 mRNA

NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081

G

laminin subunit gamma 1

affects expression

ISO

Tamoxifen affects the expression of LAMC1 mRNA

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986

G

laminin subunit gamma 2

affects expression

ISO

Tamoxifen affects the expression of LAMC2 mRNA

NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102

G

lysosomal-associated membrane protein 2

affects expression

ISO

Tamoxifen affects the expression of LAMP2 mRNA

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:121,922,187...122,087,675

G

LanC like glutathione S-transferase 1

affects expression

ISO

Tamoxifen affects the expression of LANCL1 mRNA

NCBI chr 9:75,968,284...75,998,397
Ensembl chr 9:75,968,286...76,003,475

G

La ribonucleoprotein 6, translational regulator

increases expression

ISO

Tamoxifen results in increased expression of LARP6 mRNA

NCBI chr 8:70,079,753...70,101,175
Ensembl chr 8:70,079,647...70,101,198

G

La ribonucleoprotein 7, transcriptional regulator

affects expression

ISO

Tamoxifen affects the expression of LARP7 mRNA

NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:218,672,208...218,687,308

G

LBH regulator of WNT signaling pathway

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of LBH mRNA

NCBI chr 6:28,321,040...28,344,855
Ensembl chr 6:28,321,040...28,370,238

G

LCK proto-oncogene, Src family tyrosine kinase

affects expression

ISO

Tamoxifen affects the expression of LCK mRNA

NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267

G

lipocalin 2

affects expression

ISO

Tamoxifen affects the expression of LCN2 mRNA

PMID:14699072 PMID:20937368

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lymphocyte cytosolic protein 2

affects expression

ISO

Tamoxifen affects the expression of LCP2 mRNA

NCBI chr10:19,146,846...19,193,750
Ensembl chr10:19,146,554...19,193,744

G

LIM domain binding 1

decreases expression

ISO

Tamoxifen results in decreased expression of LDB1 mRNA

NCBI chr 1:254,813,161...254,838,931
Ensembl chr 1:254,826,160...254,838,998

G

LIM domain binding 2

affects expression

ISO

Tamoxifen affects the expression of LDB2 mRNA

NCBI chr14:70,489,243...70,810,573
Ensembl chr14:70,489,620...70,810,574

G

lactate dehydrogenase A

increases expression
affects expression

ISO
EXP

Tamoxifen results in increased expression of LDHA mRNA
Tamoxifen affects the expression of LDHA mRNA

PMID:17555576 PMID:19400957

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

lactate dehydrogenase B

affects expression

ISO

Tamoxifen affects the expression of LDHB mRNA

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

lactate dehydrogenase C

affects expression

ISO

Tamoxifen affects the expression of LDHC mRNA

NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:106,522,236...106,542,802

G

low density lipoprotein receptor

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of LDLR protein
SREBF2 protein promotes the reaction [Tamoxifen results in increased expression of LDLR mRNA]; SREBF2 protein promotes the reaction [Tamoxifen results in increased expression of LDLR protein]
Tamoxifen results in increased expression of LDLR mRNA; Tamoxifen results in increased expression of LDLR protein

PMID:27358406 PMID:35944649

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

low density lipoprotein receptor class A domain containing 4

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of LDLRAD4 mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA

PMID:14699072 PMID:19059307

NCBI chr18:63,789,089...64,118,166
Ensembl chr18:63,790,440...64,113,064

G

liver enriched antimicrobial peptide 2

decreases expression

ISO

Tamoxifen results in decreased expression of LEAP2 mRNA

NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073

G

lymphoid enhancer binding factor 1

increases expression

ISO

Tamoxifen results in increased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

leucine zipper and EF-hand containing transmembrane protein 1

affects expression

ISO

Tamoxifen affects the expression of LETM1 mRNA

NCBI chr14:81,167,268...81,206,776
Ensembl chr14:81,162,309...81,209,459

G

galectin 1

affects expression

ISO

Tamoxifen affects the expression of LGALS1 mRNA

NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800

G

galectin 3

affects expression

ISO

Tamoxifen affects the expression of LGALS3 mRNA

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737

G

galectin 3 binding protein

increases expression
affects expression

ISO

Tamoxifen results in increased expression of LGALS3BP mRNA
Tamoxifen affects the expression of LGALS3BP mRNA

PMID:19155303 PMID:20937368

NCBI chr10:104,118,510...104,127,848
Ensembl chr10:104,118,510...104,127,848

G

galectin 8

decreases expression

ISO

Tamoxifen results in decreased expression of LGALS8 mRNA

NCBI chr17:62,716,368...62,744,272
Ensembl chr17:62,719,828...62,744,482

G

leucine rich repeat containing G protein coupled receptor 5

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Tamoxifen results in decreased expression of LGR5 mRNA]
Tamoxifen affects the expression of LGR5 mRNA

NCBI chr 7:52,973,151...53,107,964
Ensembl chr 7:52,974,332...53,108,163

G

luteinizing hormone subunit beta

affects secretion
decreases secretion
increases secretion
decreases expression
multiple interactions

ISO
EXP

Tamoxifen affects the secretion of LHB protein
Tamoxifen results in decreased secretion of LHB protein
Tamoxifen results in increased secretion of LHB protein
Tamoxifen results in decreased expression of LHB protein
Tamoxifen inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]

PMID:3280599 PMID:3299987 PMID:9208491 PMID:27395752

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIM homeobox 6

decreases expression

ISO

Tamoxifen results in decreased expression of LHX6 mRNA

NCBI chr 3:39,829,846...39,853,681
Ensembl chr 3:39,830,990...39,853,559

G

LIM homeobox 9

decreases expression

ISO

Tamoxifen results in decreased expression of LHX9 mRNA

NCBI chr13:52,941,207...52,961,436
Ensembl chr13:52,941,210...52,962,266

G

LIF, interleukin 6 family cytokine

multiple interactions

ISO

Tamoxifen inhibits the reaction [[bisphenol A affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [[Endosulfan affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

LIF receptor subunit alpha

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of LIFR mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of LIFR mRNA

PMID:17630414 PMID:20937368

NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364

G

DNA ligase 1

affects expression

ISO

Tamoxifen affects the expression of LIG1 mRNA

NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:83,219,545...83,281,708

G

LIM domain and actin binding 1

affects expression

ISO

Tamoxifen affects the expression of LIMA1 mRNA

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:132,780,556...132,880,386

G

LIM domain containing 2

decreases expression

ISO

Tamoxifen results in decreased expression of LIMD2 mRNA

NCBI chr10:91,590,079...91,592,747
Ensembl chr10:91,590,082...91,592,439

G

LIM domain kinase 1

affects expression

ISO

Tamoxifen affects the expression of LIMK1 mRNA

NCBI chr12:27,663,177...27,697,085
Ensembl chr12:27,663,018...27,697,209

G

lin-37 DREAM MuvB core complex component

affects expression

ISO

Tamoxifen affects the expression of LIN37 mRNA

NCBI chr 1:94,936,512...94,940,444
Ensembl chr 1:94,936,512...94,940,444

G

lin-7 homolog B, crumbs cell polarity complex component

affects expression

ISO

Tamoxifen affects the expression of LIN7B mRNA

NCBI chr 1:104,983,368...104,986,795
Ensembl chr 1:104,982,771...104,986,078

G

lipase C, hepatic type

decreases expression

ISO

Tamoxifen results in decreased expression of LIPC protein

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lipase E, hormone sensitive type

decreases expression

ISO

Tamoxifen results in decreased expression of LIPE mRNA

PMID:20937368 PMID:25123088

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117

G

lipase G, endothelial type

affects expression

ISO

Tamoxifen affects the expression of LIPG mRNA

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260

G

lipase, family member N

decreases expression

ISO

Tamoxifen results in decreased expression of LIPN mRNA

NCBI chr 1:240,998,154...241,016,658
Ensembl chr 1:240,998,154...241,016,658

G

lipopolysaccharide-induced TNF factor

decreases expression

ISO

Tamoxifen results in decreased expression of LITAF mRNA

NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930

G

LLGL scribble cell polarity complex component 2

decreases expression

ISO

Tamoxifen results in decreased expression of LLGL2 mRNA

NCBI chr10:101,549,911...101,585,466
Ensembl chr10:101,549,862...101,585,464

G

LIM and cysteine-rich domains 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA

NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875

G

lamin A/C

affects expression

ISO

Tamoxifen affects the expression of LMNA mRNA

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

lamin B2

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of LMNB2 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:9,443,308...9,459,468
Ensembl chr 7:9,440,128...9,459,342

G

leiomodin 1

affects expression

ISO

Tamoxifen affects the expression of LMOD1 mRNA

NCBI chr13:49,305,693...49,347,970
Ensembl chr13:49,305,830...49,348,116

G

lysophosphatidylcholine acyltransferase 4

affects expression

ISO

Tamoxifen affects the expression of LPCAT4 mRNA

NCBI chr 3:119,499,128...119,507,275
Ensembl chr 3:119,499,128...119,507,362

G

lipin 1

affects expression

ISO

Tamoxifen affects the expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

lipoprotein lipase

affects expression
decreases expression
multiple interactions

ISO

Tamoxifen affects the expression of LPL mRNA
Tamoxifen results in decreased expression of LPL protein
[Tamoxifen co-treated with ESR1 protein] results in increased expression of LPL mRNA

PMID:3108557 PMID:14699072 PMID:17555576 PMID:19059307 PMID:20937368

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LIM domain containing preferred translocation partner in lipoma

affects expression

ISO

Tamoxifen affects the expression of LPP mRNA

NCBI chr11:89,292,060...89,933,973
Ensembl chr11:89,305,187...89,805,264

G

leucine rich repeat and fibronectin type III domain containing 4

affects expression

ISO

Tamoxifen affects the expression of LRFN4 mRNA

NCBI chr 1:211,317,980...211,321,272
Ensembl chr 1:211,317,980...211,321,272

G

leucine-rich alpha-2-glycoprotein 1

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of LRG1 mRNA

NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337

G

leucine-rich repeats and immunoglobulin-like domains 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA
Tamoxifen affects the expression of LRIG1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 4:128,687,723...128,788,219
Ensembl chr 4:128,687,723...128,788,219

G

LDL receptor related protein 1B

affects expression

ISO

Tamoxifen affects the expression of LRP1B mRNA

NCBI chr 3:45,004,001...47,125,147
Ensembl chr 3:45,004,689...45,957,692

G

leucine rich repeat containing 20

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA

NCBI chr20:29,965,673...30,071,185
Ensembl chr20:29,972,001...30,071,184

G

leucine rich repeat containing 23

affects expression

ISO

Tamoxifen affects the expression of LRRC23 mRNA

NCBI chr 4:159,267,572...159,277,764
Ensembl chr 4:159,267,574...159,277,794

G

leucine rich repeat containing 41

affects expression

ISO

Tamoxifen affects the expression of LRRC41 mRNA

NCBI chr 5:134,791,256...134,812,177
Ensembl chr 5:134,791,256...134,812,177

G

LRR binding FLII interacting protein 1

affects expression

ISO

Tamoxifen affects the expression of LRRFIP1 mRNA

NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:99,039,614...99,167,779

G

LRR binding FLII interacting protein 2

affects expression

ISO

Tamoxifen affects the expression of LRRFIP2 mRNA

NCBI chr 8:119,969,908...120,071,270
Ensembl chr 8:119,969,871...120,073,475

G

lanosterol synthase

decreases expression
increases expression

ISO

Tamoxifen results in decreased expression of LSS mRNA
Tamoxifen results in increased expression of LSS mRNA

PMID:15342952 PMID:15590111 PMID:17567588

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

latent transforming growth factor beta binding protein 1

affects expression

ISO

Tamoxifen affects the expression of LTBP1 mRNA

NCBI chr 6:25,781,625...26,177,346
Ensembl chr 6:25,781,638...26,454,036

G

latent transforming growth factor beta binding protein 2

affects expression

ISO

Tamoxifen affects the expression of LTBP2 mRNA

NCBI chr 6:110,161,029...110,261,586
Ensembl chr 6:110,161,029...110,257,298

G

lactotransferrin

affects expression
multiple interactions
increases expression

ISO
EXP

Tamoxifen affects the expression of LTF mRNA
[Ethinyl Estradiol co-treated with Tamoxifen] results in increased expression of LTF protein
Tamoxifen results in increased expression of LTF protein

PMID:11390168 PMID:17555576 PMID:24487097

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189

G

LUC7 pre-mRNA splicing factor like 1

affects expression

ISO

Tamoxifen affects the expression of LUC7L mRNA

NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,777,829...15,817,940

G

lumican

affects expression

ISO

Tamoxifen affects the expression of LUM mRNA

NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:34,245,360...34,252,508

G

lymphocyte antigen 6 family member A

affects expression

ISO

Tamoxifen affects the expression of LY6A mRNA

PMID:17555576 PMID:20937368

NCBI chr 7:109,064,222...109,067,757

G

lymphocyte antigen 6 family member E

increases expression
decreases expression
affects expression

ISO
EXP

Tamoxifen results in increased expression of LY6E mRNA
Tamoxifen results in decreased expression of LY6E mRNA
Tamoxifen affects the expression of LY6E mRNA

PMID:17555576 PMID:19400957 PMID:25123088

NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443

G

lymphocyte antigen 6 family member G6D

increases expression

ISO

Tamoxifen results in increased expression of LY6G6D mRNA

NCBI chr20:3,746,630...3,757,036
Ensembl chr20:3,742,116...3,757,193

G

LYN proto-oncogene, Src family tyrosine kinase

affects expression

ISO

Tamoxifen affects the expression of LYN mRNA

NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461

G

LysM domain containing 2

affects expression
increases expression

ISO

Tamoxifen affects the expression of LYSMD2 mRNA
Tamoxifen results in increased expression of LYSMD2 mRNA

PMID:17555576 PMID:25123088

NCBI chr 8:85,259,443...85,274,876
Ensembl chr 8:85,259,410...85,275,241

G

LysM domain containing 4

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA

NCBI chr 1:130,249,340...130,255,357
Ensembl chr 1:130,249,479...130,255,357

G

lymphatic vessel endothelial hyaluronan receptor 1

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of XLKD1 mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of XLKD1 mRNA

PMID:17630414 PMID:20937368

NCBI chr 1:174,393,387...174,410,977

G

lysozyme-like 1

affects expression

ISO

Tamoxifen affects the expression of LYZL1 mRNA

NCBI chr17:58,225,664...58,239,120
Ensembl chr17:58,225,152...58,239,095

G

microtubule-actin crosslinking factor 1

affects expression

ISO

Tamoxifen affects the expression of MACF1 mRNA

NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:140,908,837...141,233,890

G

macroH2A.1 histone

affects expression

ISO

Tamoxifen affects the expression of MACROH2A1 mRNA

NCBI chr17:8,484,340...8,547,268
Ensembl chr17:8,484,246...8,547,257

G

MAF bZIP transcription factor

affects expression

ISO

Tamoxifen affects the expression of MAF mRNA

NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378

G

MAF1 homolog, negative regulator of RNA polymerase III

affects expression

ISO

Tamoxifen affects the expression of MAF1 mRNA

NCBI chr 7:109,955,876...109,958,909
Ensembl chr 7:109,955,282...109,958,910

G

MAF bZIP transcription factor B

affects expression

ISO

Tamoxifen affects the expression of MAFB mRNA

NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975

G

MAF bZIP transcription factor F

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAFF mRNA; ESR2 protein affects the reaction [Tamoxifen results in decreased expression of MAFF mRNA]

PMID:14699072 PMID:19059307

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAF bZIP transcription factor K

increases expression

ISO

Tamoxifen results in increased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

myelin-associated glycoprotein

decreases expression

EXP

Tamoxifen results in decreased expression of MAG mRNA

NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:95,275,635...95,291,060

G

MAGE family member B18

affects expression

ISO

Tamoxifen affects the expression of MAGEB18 mRNA

NCBI chr X:60,861,961...61,456,154
Ensembl chr X:60,850,421...62,000,917

G

MAGE family member D2

affects expression

ISO

Tamoxifen affects the expression of MAGED2 mRNA

NCBI chr X:23,160,928...23,364,994
Ensembl chr X:23,160,931...23,169,104

G

mago homolog, exon junction complex subunit

affects expression

ISO

Tamoxifen affects the expression of MAGOH mRNA

NCBI chr 5:127,868,044...127,875,423
Ensembl chr 5:127,868,055...127,875,384

G

mago homolog B, exon junction complex subunit

affects expression

ISO

Tamoxifen affects the expression of MAGOHB mRNA

NCBI chr 4:166,765,558...166,773,406
Ensembl chr 4:166,765,618...166,773,851

G

MAK16 homolog

affects expression

ISO

Tamoxifen affects the expression of RBM13 mRNA

NCBI chr16:67,675,757...67,684,188
Ensembl chr16:67,675,735...67,684,836

G

mastermind-like transcriptional coactivator 3

increases expression

ISO

Tamoxifen results in increased expression of MAML3 mRNA

NCBI chr 2:137,871,267...138,288,615
Ensembl chr 2:137,871,267...138,287,960

G

mannosidase, alpha, class 2B, member 2

affects expression

ISO

Tamoxifen affects the expression of MAN2B2 mRNA

NCBI chr14:78,193,797...78,218,802
Ensembl chr14:78,193,725...78,227,724

G

mannosidase beta

affects expression

ISO

Tamoxifen affects the expression of MANBA mRNA

NCBI chr 2:226,583,968...226,676,520
Ensembl chr 2:226,583,917...226,676,517

G

mesencephalic astrocyte-derived neurotrophic factor

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of MANF mRNA
Tamoxifen results in increased expression of MANF mRNA

PMID:17555576 PMID:19400957 PMID:20937368

NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:116,427,048...116,429,910

G

monoamine oxidase A

multiple interactions
increases expression

EXP

Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA protein]
Tamoxifen results in increased expression of MAOA mRNA; Tamoxifen results in increased expression of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

increases expression
multiple interactions

EXP

Tamoxifen results in increased expression of MAOB mRNA; Tamoxifen results in increased expression of MAOB protein
Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB protein]

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 1A

increases expression

ISO

Tamoxifen results in increased expression of MAP1A mRNA

NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:128,716,940...128,740,159

G

microtubule-associated protein 1 light chain 3 alpha

affects expression

ISO

Tamoxifen affects the expression of MAP1LC3A mRNA

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850

G

microtubule-associated protein 1 light chain 3 beta

decreases response to substance
increases expression
affects expression
multiple interactions

ISO

MAP1LC3B protein results in decreased susceptibility to Tamoxifen
Tamoxifen results in increased expression of MAP1LC3B protein
Tamoxifen affects the expression of MAP1LC3B mRNA
Tamoxifen promotes the reaction [Nelfinavir results in increased expression of MAP1LC3B protein]

PMID:17555576 PMID:20479004 PMID:20594311 PMID:25301941

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase kinase 1

multiple interactions
increases expression
decreases expression

ISO
EXP

Tamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein]
Tamoxifen results in increased expression of MAP2K1 protein modified form
Tamoxifen results in decreased expression of MAP2K1 protein modified form

PMID:17901229 PMID:20479004

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen activated protein kinase kinase 4

increases expression

ISO

Tamoxifen results in increased expression of MAP2K4 mRNA

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

mitogen-activated protein kinase kinase kinase 1

affects expression

ISO

Tamoxifen affects the expression of MAP3K1 mRNA

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen-activated protein kinase kinase kinase 13

increases expression

ISO

Tamoxifen results in increased expression of MAP3K13 mRNA

NCBI chr11:92,596,436...92,741,717
Ensembl chr11:92,601,738...92,739,663

G

mitogen-activated protein kinase kinase kinase 20

decreases expression

ISO

Tamoxifen results in decreased expression of MAP3K20 mRNA

NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA

NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452

G

microtubule-associated protein 4

affects expression

ISO

Tamoxifen affects the expression of MAP4 mRNA

NCBI chr 8:118,800,393...118,942,805
Ensembl chr 8:118,804,022...118,942,805

G

microtubule-associated protein 7

affects expression

ISO

Tamoxifen affects the expression of MAP7 mRNA

NCBI chr 1:16,730,000...16,857,173
Ensembl chr 1:16,730,075...16,857,170

G

MAP7 domain containing 1

affects expression

ISO

Tamoxifen affects the expression of MAP7D1 mRNA

NCBI chr 5:143,812,467...143,837,597
Ensembl chr 5:143,811,924...143,837,021

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
decreases expression
decreases activity
decreases phosphorylation

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AG 1879 inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein promotes the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tamoxifen inhibits the reaction [U 0126 results in decreased phosphorylation of MAPK1 protein]; Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein; TP53 protein inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Tamoxifen results in increased phosphorylation of MAPK1 protein]
Tamoxifen results in decreased expression of MAPK1 protein modified form
Tamoxifen results in decreased activity of MAPK1 protein
Tamoxifen inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]
Tamoxifen results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Tamoxifen analog results in increased phosphorylation of MAPK1 protein; Tamoxifen results in increased phosphorylation of MAPK1 protein

PMID:16713447 PMID:17011908 PMID:17901229 PMID:19393235 PMID:19549922 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

affects expression

ISO

Tamoxifen affects the expression of MAPK10 mRNA

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen-activated protein kinase 11

decreases expression

ISO

Tamoxifen results in decreased expression of MAPK11 mRNA

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen-activated protein kinase 12

multiple interactions
increases phosphorylation
decreases response to substance

ISO

[pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; JUN protein inhibits the reaction [MAPK12 mutant form results in decreased susceptibility to Tamoxifen]; Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein modified form]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein]; Tamoxifen results in increased activity of and results in increased expression of MAPK12 protein
Tamoxifen results in increased phosphorylation of MAPK12 protein

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 14

increases activity
multiple interactions

ISO

Tamoxifen results in increased activity of MAPK14 protein
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
decreases expression
decreases activity
increases activity
decreases phosphorylation

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AG 1879 inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein promotes the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tamoxifen inhibits the reaction [U 0126 results in decreased phosphorylation of MAPK3 protein]; Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein; TP53 protein inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Tamoxifen results in increased phosphorylation of MAPK3 protein]
Tamoxifen results in decreased expression of MAPK3 protein modified form
Tamoxifen results in decreased activity of MAPK3 protein
Tamoxifen inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]
Tamoxifen results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Tamoxifen analog results in increased phosphorylation of MAPK3 protein; Tamoxifen results in increased phosphorylation of MAPK3 protein

PMID:14645110 PMID:16713447 PMID:17011908 PMID:17901229 PMID:19393235 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 7

affects expression

ISO

Tamoxifen affects the expression of MAPK7 mRNA

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

mitogen-activated protein kinase 8

multiple interactions
increases activity

ISO

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK8 protein]
Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of MAPK8 protein]; Tamoxifen inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK8 protein]

PMID:14645110 PMID:23038002

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of MAPK9 mRNA
Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of MAPK9 protein]; Tamoxifen inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK9 protein]

PMID:14699072 PMID:23038002

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MAPK activated protein kinase 2

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA
Tamoxifen results in increased expression of MAPKAPK2 mRNA

PMID:19059307 PMID:25123088

NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326

G

microtubule-associated protein tau

multiple interactions
affects expression
increases expression

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of MAPT protein]
Tamoxifen affects the expression of MAPT mRNA
Tamoxifen results in increased expression of MAPT protein

PMID:17555576 PMID:20579400

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

myristoylated alanine rich protein kinase C substrate

affects expression

ISO

Tamoxifen affects the expression of MARCKS mRNA

NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882

G

MARCKS-like 1

affects expression

ISO

Tamoxifen affects the expression of MARCKSL1 mRNA

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:147,134,514...147,138,417

G

macrophage receptor with collagenous structure

increases expression

ISO

Tamoxifen results in increased expression of MARCO mRNA

NCBI chr13:34,169,011...34,210,340
Ensembl chr13:34,169,011...34,201,255

G

microtubule affinity regulating kinase 1

increases expression

ISO

Tamoxifen results in increased expression of MARK1 mRNA

NCBI chr13:98,981,727...99,086,998
Ensembl chr13:98,983,020...99,086,701

G

MARVEL domain containing 3

increases expression

ISO

Tamoxifen results in increased expression of MARVELD3 mRNA

NCBI chr19:54,818,180...54,832,871
Ensembl chr19:54,818,180...54,832,871

G

MAS1 proto-oncogene, G protein-coupled receptor

decreases expression

ISO

Tamoxifen results in decreased expression of MAS1 mRNA

NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561

G

methionine adenosyltransferase 1A

decreases expression

ISO

Tamoxifen results in decreased expression of MAT1A mRNA

NCBI chr16:17,017,168...17,035,368
Ensembl chr16:17,016,030...17,035,367

G

matrilin 2

affects expression

ISO

Tamoxifen affects the expression of MATN2 mRNA

NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:67,380,168...67,530,153

G

matrin 3

affects expression

ISO

Tamoxifen affects the expression of MATR3 mRNA

NCBI chr18:27,428,190...27,474,421
Ensembl chr18:27,432,179...27,470,421

G

myoglobin

affects expression

ISO

Tamoxifen affects the expression of MB mRNA

NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958

G

methyl-CpG binding domain protein 1

affects expression

ISO

Tamoxifen affects the expression of MBD1 mRNA

NCBI chr18:70,145,093...70,159,744
Ensembl chr18:70,145,114...70,159,703

G

methyl-CpG binding domain protein 3

affects expression

ISO

Tamoxifen affects the expression of MBD3 mRNA

NCBI chr 7:9,961,053...9,970,845
Ensembl chr 7:9,963,797...9,970,265

G

methyl-CpG binding domain protein 5

increases expression

ISO

Tamoxifen results in increased expression of MBD5 mRNA

NCBI chr 3:53,742,458...54,147,970
Ensembl chr 3:54,075,084...54,139,389

G

muscleblind-like splicing regulator 1

affects expression

ISO

Tamoxifen affects the expression of MBNL1 mRNA

NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134

G

muscleblind-like splicing regulator 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

membrane bound O-acyltransferase domain containing 2

affects expression

ISO

Tamoxifen affects the expression of MBOAT2 mRNA

NCBI chr 6:47,199,751...47,326,215
Ensembl chr 6:47,199,774...47,326,208

G

myelin basic protein

multiple interactions
increases expression

ISO

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein]

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

melanocortin 2 receptor

decreases expression

ISO

Tamoxifen results in decreased expression of MC2R mRNA

NCBI chr18:64,279,878...64,291,775
Ensembl chr18:64,277,360...64,291,881

G

multiple coagulation factor deficiency 2, ER cargo receptor complex subunit

affects expression

ISO

Tamoxifen affects the expression of MCFD2 mRNA

NCBI chr 6:13,028,036...13,039,388
Ensembl chr 6:13,016,104...13,039,379

G

MCL1 apoptosis regulator, BCL2 family member

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of MCL1 mRNA
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 protein

PMID:17555576 PMID:22046442

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

minichromosome maintenance complex component 2

affects expression

ISO

Tamoxifen affects the expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094

G

minichromosome maintenance complex component 4

multiple interactions

ISO

Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MCM4 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of MCM4 mRNA]

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:98,762,634...98,776,536

G

minichromosome maintenance complex component 5

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of MCM5 mRNA]

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,488,813...13,517,758

G

minichromosome maintenance complex component 6

increases expression
affects expression
multiple interactions

ISO

Tamoxifen results in increased expression of MCM6 protein
Tamoxifen affects the expression of MCM6 mRNA
[Tretinoin co-treated with Tamoxifen] results in increased expression of MCM6 protein

PMID:17098229 PMID:17555576

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467

G

minichromosome maintenance complex component 7

decreases expression
multiple interactions

ISO

Tamoxifen results in decreased expression of MCM7 mRNA
Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MCM7 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of MCM7 mRNA]

PMID:15604281 PMID:24758408

NCBI chr12:22,155,921...22,163,320
Ensembl chr12:22,155,921...22,163,771

G

mitochondrial calcium uniporter

decreases expression

ISO

Tamoxifen results in decreased expression of MCU mRNA

NCBI chr20:27,960,520...28,123,103
Ensembl chr20:27,961,327...28,123,103

G

MyoD family inhibitor domain containing

affects expression
increases expression
multiple interactions

ISO

Tamoxifen affects the expression of MDFIC mRNA
Tamoxifen results in increased expression of MDFIC mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA

PMID:14699072 PMID:19059307 PMID:25123088

NCBI chr 4:44,938,301...45,018,157
Ensembl chr 4:44,938,480...45,018,156

G

malate dehydrogenase 2

affects expression

ISO

Tamoxifen affects the expression of MDH2 mRNA

NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841

G

midkine

affects expression

ISO

Tamoxifen affects the expression of MDK mRNA

NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743

G

MDM2 proto-oncogene

affects expression
decreases expression

ISO

Tamoxifen affects the expression of MDM2 mRNA
Tamoxifen results in decreased expression of MDM2 mRNA

PMID:17555576 PMID:34821461

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MDM4 regulator of p53

decreases expression

ISO

Tamoxifen results in decreased expression of MDM4 mRNA

NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372

G

midasin AAA ATPase 1

affects expression

ISO

Tamoxifen affects the expression of MDN1 mRNA

NCBI chr 5:51,851,785...51,982,688
Ensembl chr 5:51,851,809...51,982,688

G

malic enzyme 3

increases expression

ISO

Tamoxifen results in increased expression of ME3 mRNA

NCBI chr 1:152,946,595...153,148,026
Ensembl chr 1:152,946,628...153,148,026

G

mediator complex subunit 11

affects expression

ISO

Tamoxifen affects the expression of MED11 mRNA

NCBI chr10:55,662,956...55,664,574
Ensembl chr10:55,663,001...55,664,765

G

mediator complex subunit 28

affects expression

ISO

Tamoxifen affects the expression of MED28 mRNA

NCBI chr14:69,807,319...69,816,115
Ensembl chr14:69,807,319...69,816,115

G

myocyte enhancer factor 2a

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162

G

meiosis/spermiogenesis associated 1

affects expression

ISO

Tamoxifen affects the expression of MEIG1 mRNA

NCBI chr17:79,718,630...79,737,604
Ensembl chr17:79,723,811...79,737,533

G

menin 1

decreases response to substance
multiple interactions
affects expression

ISO

MEN1 protein results in decreased susceptibility to Tamoxifen
Tamoxifen inhibits the reaction [MEN1 protein binds to ESR1 protein]
Tamoxifen affects the expression of MEN1 mRNA

PMID:17555576 PMID:19847644

NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:213,068,166...213,074,120

G

MER proto-oncogene, tyrosine kinase

multiple interactions

ISO

Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of MERTK mRNA]

NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:136,383,560...136,500,192

G

methyltransferase 1, tRNA methylguanosine

affects expression

ISO

Tamoxifen affects the expression of METTL1 mRNA

NCBI chr 7:64,750,189...64,754,531
Ensembl chr 7:64,750,198...64,754,639

G

microfibril associated protein 2

affects expression

ISO

Tamoxifen affects the expression of MFAP2 mRNA

NCBI chr 5:158,595,121...158,603,283
Ensembl chr 5:158,597,512...158,610,656

G

microfibril associated protein 3

affects expression

ISO

Tamoxifen affects the expression of MFAP3 mRNA

NCBI chr10:42,197,292...42,213,011
Ensembl chr10:42,197,275...42,210,988

G

mitofusin 2

decreases expression

ISO

Tamoxifen results in decreased expression of MFN2 mRNA

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

affects expression

ISO

Tamoxifen affects the expression of MGAT1 mRNA

NCBI chr10:34,064,548...34,083,833
Ensembl chr10:34,062,837...34,095,975

G

O-6-methylguanine-DNA methyltransferase

decreases activity
increases degradation
multiple interactions
decreases expression

ISO

Tamoxifen results in decreased activity of MGMT protein
Tamoxifen results in increased degradation of MGMT protein
[Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tamoxifen results in increased degradation of MGMT protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to MGMT protein]
Tamoxifen results in decreased expression of MGMT protein

PMID:17597106 PMID:23665804

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

matrix Gla protein

decreases expression
multiple interactions
affects expression

EXP
ISO

Tamoxifen results in decreased expression of MGP mRNA
[bexarotene co-treated with Tamoxifen] results in decreased expression of MGP mRNA
Tamoxifen affects the expression of MGP mRNA

PMID:17630414 PMID:19400957 PMID:20937368

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859

G

microsomal glutathione S-transferase 1

affects expression

ISO

Tamoxifen affects the expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

MICAL-like 2

increases expression

ISO

Tamoxifen results in increased expression of MICALL2 mRNA

NCBI chr12:20,013,037...20,041,795
Ensembl chr12:20,012,985...20,041,795

G

MID1 interacting protein 1

affects expression

ISO

Tamoxifen affects the expression of MID1IP1 mRNA

NCBI chr X:14,733,539...14,735,859
Ensembl chr X:14,732,830...14,739,079

G

midnolin

affects expression

ISO

Tamoxifen affects the expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:10,200,306...10,207,203

G

microRNA 106a

multiple interactions
increases expression

EXP

[Tamoxifen results in increased expression of MIR106A mRNA] which results in decreased expression of RB1 protein

NCBI chr X:137,343,570...137,343,647

G

microRNA 152

decreases expression

EXP

Tamoxifen results in decreased expression of MIR152 mRNA

NCBI chr10:82,329,383...82,329,467
Ensembl chr10:82,329,383...82,329,467

G

microRNA mir-15a

increases expression

EXP

Tamoxifen results in increased expression of MIR15A mRNA

G

microRNA 16-2

multiple interactions
increases expression

EXP

[Tamoxifen results in increased expression of MIR16-2 mRNA] which results in decreased expression of BCL2 protein

NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421

G

microRNA 17

multiple interactions
increases expression

EXP

[Tamoxifen results in increased expression of MIR17 mRNA] which results in decreased expression of E2F1 protein

NCBI chr15:98,587,848...98,587,931
Ensembl chr15:98,587,848...98,587,931

G

microRNA 18a

increases expression

EXP

Tamoxifen results in increased expression of MIR18 mRNA

NCBI chr15:98,587,984...98,588,079
Ensembl chr15:98,587,984...98,588,079

G

microRNA 191

decreases expression

EXP

Tamoxifen results in decreased expression of MIR191 mRNA

NCBI chr 8:118,142,627...118,142,717

G

microRNA 192

decreases expression

EXP

Tamoxifen results in decreased expression of MIR192 mRNA

NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:212,994,209...212,994,318

G

microRNA 193a

increases expression

EXP

Tamoxifen results in increased expression of MIR193A mRNA

NCBI chr10:65,170,306...65,170,417

G

microRNA 195

decreases expression

EXP

Tamoxifen results in decreased expression of MIR195 mRNA

NCBI chr10:55,450,495...55,450,581
Ensembl chr10:55,450,495...55,450,581

G

microRNA 203

decreases expression

EXP

Tamoxifen results in decreased expression of MIR203 mRNA

NCBI chr 6:137,020,691...137,020,805

G

microRNA 20a

increases expression

EXP

Tamoxifen results in increased expression of MIR20A mRNA

NCBI chr15:98,588,303...98,588,387
Ensembl chr15:98,588,303...98,588,387

G

microRNA 20b

increases expression

EXP

Tamoxifen results in increased expression of MIR20B mRNA

NCBI chr X:137,343,197...137,343,268

G

microRNA 22

decreases expression

EXP

Tamoxifen results in decreased expression of MIR22 mRNA

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,805,331...60,805,425

G

microRNA 25

increases expression

EXP

Tamoxifen results in increased expression of MIR25 mRNA

NCBI chr12:22,156,641...22,156,724

G

microRNA 27a

decreases expression

EXP

Tamoxifen results in decreased expression of MIR27A mRNA

NCBI chr19:40,859,603...40,859,689

G

microRNA 28

decreases expression

EXP

Tamoxifen results in decreased expression of MIR28 mRNA

NCBI chr11:89,480,252...89,480,337

G

microRNA 322

increases expression

EXP

Tamoxifen results in increased expression of MIR424 mRNA

NCBI chr X:137,726,147...137,726,241

G

microRNA 324

increases expression

EXP

Tamoxifen results in increased expression of MIR324 mRNA

NCBI chr10:55,233,363...55,233,445
Ensembl chr10:55,233,361...55,233,449

G

microRNA 345

increases expression

EXP

Tamoxifen results in increased expression of MIR345 mRNA

NCBI chr 6:133,518,403...133,518,498
Ensembl chr 6:133,518,403...133,518,498

G

microRNA 34a

multiple interactions
increases expression

EXP

[Tamoxifen results in increased expression of MIR34A mRNA] which results in decreased expression of NOTCH1 protein

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053

G

microRNA 34b

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in decreased expression of MIR34B mRNA]

NCBI chr 8:60,306,609...60,306,692

G

microRNA 350

decreases expression

EXP

Tamoxifen results in decreased expression of MIR350 mRNA

NCBI chr13:91,244,534...91,244,632

G

microRNA 361

decreases expression

EXP

Tamoxifen results in decreased expression of MIR361 mRNA

NCBI chr X:82,438,463...82,438,532

G

microRNA 362

increases expression

EXP

Tamoxifen results in increased expression of MIR362 mRNA

NCBI chr X:17,926,485...17,926,549
Ensembl chr X:17,926,485...17,926,549

G

microRNA 365b

increases expression

EXP

Tamoxifen results in increased expression of MIR365B mRNA

NCBI chr10:65,184,217...65,184,302
Ensembl chr10:65,184,214...65,184,313

G

microRNA 375

increases expression

EXP

Tamoxifen results in increased expression of MIR375 mRNA

NCBI chr 9:83,906,582...83,906,656

G

microRNA 378

decreases expression

EXP

Tamoxifen results in decreased expression of MIR378A mRNA

NCBI chr18:57,128,922...57,128,986

G

microRNA 92a-1

multiple interactions
increases expression

EXP

[Tamoxifen results in increased expression of MIR92A1 mRNA] which results in decreased expression of E2F1 protein

NCBI chr15:98,588,555...98,588,632
Ensembl chr15:98,588,555...98,588,632

G

microRNA 93

increases expression

EXP

Tamoxifen results in increased expression of MIR93 mRNA

NCBI chr12:22,156,844...22,156,930

G

melanocyte inducing transcription factor

increases expression

ISO

Tamoxifen results in increased expression of MITF mRNA

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790

G

marker of proliferation Ki-67

multiple interactions
decreases expression
increases expression

ISO
EXP

[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein; [Tamoxifen co-treated with anastrozole] results in decreased expression of MKI67 protein
Tamoxifen results in decreased expression of MKI67 protein
Tamoxifen results in increased expression of MKI67 protein
Quercetin promotes the reaction [Tamoxifen results in decreased expression of MKI67 protein]

PMID:12627041 PMID:15067354 PMID:15767642 PMID:16002280 PMID:17219426 More...

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

muskelin 1

affects expression

ISO

Tamoxifen affects the expression of MKLN1 mRNA

NCBI chr 4:60,939,239...61,095,214
Ensembl chr 4:60,937,817...61,095,210

G

makorin, ring finger protein, 2

affects expression

ISO

Tamoxifen affects the expression of MKRN2 mRNA

NCBI chr 4:150,334,164...150,352,271
Ensembl chr 4:150,334,142...150,352,263

G

melan-A

decreases expression

ISO

Tamoxifen results in decreased expression of MLANA mRNA

NCBI chr 1:236,883,075...236,897,693
Ensembl chr 1:236,883,075...236,896,880

G

modulator of VRAC current 1

affects expression

ISO

Tamoxifen affects the expression of MLC1 mRNA

NCBI chr 7:121,926,356...121,949,484
Ensembl chr 7:121,926,356...121,946,698

G

MAX dimerization protein MLX

affects expression

ISO

Tamoxifen affects the expression of MLX mRNA

NCBI chr10:86,519,517...86,524,607
Ensembl chr10:86,519,864...86,524,772

G

MLX interacting protein-like

affects expression

ISO

Tamoxifen affects the expression of MLXIPL mRNA

NCBI chr12:27,178,158...27,213,675
Ensembl chr12:27,178,158...27,213,660

G

monocyte to macrophage differentiation-associated 2

affects expression
increases expression
multiple interactions

ISO

Tamoxifen affects the expression of MMD2 mRNA
Tamoxifen results in increased expression of MMD2 mRNA
ESR1 protein affects the reaction [Tamoxifen results in increased expression of MMD2 mRNA]

PMID:20937368 PMID:22841776 PMID:25123088

NCBI chr12:17,075,870...17,123,255
Ensembl chr12:17,076,260...17,123,904

G

membrane metallo-endopeptidase

affects expression

ISO

Tamoxifen affects the expression of MME mRNA

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463

G

matrix metallopeptidase 1

multiple interactions
decreases activity
decreases expression

ISO

Tamoxifen promotes the reaction [ESR1 protein binds to MMP1 promoter]; Tamoxifen promotes the reaction [FOS protein binds to MMP1 promoter]
Tamoxifen results in decreased activity of MMP1 protein
Tamoxifen results in decreased expression of MMP1 mRNA

PMID:17157789 PMID:19393235

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 12

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478

G

matrix metallopeptidase 14

decreases expression

ISO

Tamoxifen results in decreased expression of MMP14 mRNA; Tamoxifen results in decreased expression of MMP14 protein

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 2

affects expression
multiple interactions
decreases expression
increases activity
decreases activity

ISO

Tamoxifen affects the expression of MMP2 mRNA
Tamoxifen affects the reaction [Quercetin affects the expression of MMP2 mRNA]
Tamoxifen results in decreased expression of MMP2 mRNA
Tamoxifen results in increased activity of MMP2 protein
Tamoxifen results in decreased activity of MMP2 protein

PMID:17555576 PMID:19279558 PMID:19393235 PMID:30153467 PMID:32530119

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 3

affects expression

ISO

Tamoxifen affects the expression of MMP3 mRNA

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

affects expression
multiple interactions
decreases expression
increases expression
increases activity
decreases activity

ISO
EXP

Tamoxifen affects the expression of MMP9 mRNA
Tamoxifen affects the reaction [Quercetin affects the expression of MMP9 mRNA]
Tamoxifen results in decreased expression of MMP9 mRNA
Tamoxifen results in increased expression of MMP9 mRNA
Tamoxifen results in increased activity of MMP9 protein
Tamoxifen results in decreased activity of MMP9 protein

PMID:14699072 PMID:15696052 PMID:17555576 PMID:19279558 PMID:19393235 More...

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MN1 proto-oncogene, transcriptional regulator

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MN1 mRNA
Tamoxifen results in increased expression of MN1 mRNA

PMID:19059307 PMID:25123088

NCBI chr12:50,841,632...50,880,795
Ensembl chr12:50,841,632...50,880,795

G

myeloid cell nuclear differentiation antigen

affects expression

ISO

Tamoxifen affects the expression of PYHIN1 mRNA

NCBI chr13:88,550,224...88,567,892
Ensembl chr13:88,550,228...88,566,537

G

MAX network transcriptional repressor

affects expression

ISO

Tamoxifen affects the expression of MNT mRNA

NCBI chr10:60,197,654...60,213,221
Ensembl chr10:60,197,948...60,213,209

G

monoacylglycerol O-acyltransferase 2

decreases expression

ISO

Tamoxifen results in decreased expression of MOGAT2 mRNA

NCBI chr 1:162,933,964...162,957,896
Ensembl chr 1:162,933,966...162,957,896

G

MOK protein kinase

increases expression

ISO

Tamoxifen results in increased expression of MOK mRNA

NCBI chr 6:135,645,018...135,675,894
Ensembl chr 6:135,645,018...135,676,174

G

MORC family CW-type zinc finger 3

affects expression

ISO

Tamoxifen affects the expression of MORC3 mRNA

NCBI chr11:46,621,575...46,664,315
Ensembl chr11:46,621,548...46,664,309

G

mortality factor 4 like 2

affects expression

ISO

Tamoxifen affects the expression of MORF4L2 mRNA

PMID:14699072 PMID:17555576

NCBI chr X:104,874,850...104,885,946
Ensembl chr X:104,852,693...104,892,855

G

mannose-P-dolichol utilization defect 1

affects expression

ISO

Tamoxifen affects the expression of MPDU1 mRNA

NCBI chr10:54,873,467...54,880,536
Ensembl chr10:54,873,473...54,879,195

G

macrophage expressed 1

affects expression

ISO

Tamoxifen affects the expression of MPEG1 mRNA

NCBI chr 1:218,876,848...218,881,364
Ensembl chr 1:218,876,069...218,908,715

G

metallophosphoesterase domain containing 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA

NCBI chr 3:113,635,614...113,810,307
Ensembl chr 3:113,635,407...113,811,783

G

mercaptopyruvate sulfurtransferase

affects expression

ISO

Tamoxifen affects the expression of MPST mRNA

NCBI chr 7:111,836,079...111,843,651
Ensembl chr 7:111,835,587...111,843,650

G

myelin protein zero-like 2

affects expression

ISO

Tamoxifen affects the expression of MPZL2 mRNA

NCBI chr 8:54,244,920...54,256,064
Ensembl chr 8:54,243,556...54,256,074

G

major histocompatibility complex, class I-related

increases expression

ISO

Tamoxifen results in increased expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

mannose receptor, C type 1

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in decreased expression of MRC1 mRNA

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

mitochondrial ribosomal protein L13

affects expression

ISO

Tamoxifen affects the expression of MRPL13 mRNA

NCBI chr 7:88,841,265...88,862,821
Ensembl chr 7:88,841,266...88,862,848

G

mitochondrial ribosomal protein L17

affects expression

ISO

Tamoxifen affects the expression of MRPL17 mRNA

NCBI chr 1:169,574,010...169,575,699
Ensembl chr 1:169,574,010...169,575,818

G

mitochondrial ribosomal protein L2

affects expression

ISO

Tamoxifen affects the expression of MRPL2 mRNA

NCBI chr 9:21,830,834...21,834,607
Ensembl chr 9:21,830,835...21,834,641

G

mitochondrial ribosomal protein L24

affects expression

ISO

Tamoxifen affects the expression of MRPL24 mRNA

NCBI chr 2:175,680,872...175,687,107
Ensembl chr 2:175,681,070...175,688,660

G

mitochondrial ribosomal protein L3

affects expression

ISO

Tamoxifen affects the expression of MRPL3 mRNA

NCBI chr 8:114,548,970...114,572,330
Ensembl chr 8:114,548,970...114,573,996

G

mitochondrial ribosomal protein L33

affects expression

ISO

Tamoxifen affects the expression of MRPL33 mRNA

NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987

G

mitochondrial ribosomal protein L37

affects expression

ISO

Tamoxifen affects the expression of MRPL37 mRNA

NCBI chr 5:127,056,679...127,075,000
Ensembl chr 5:127,058,716...127,074,980

G

mitochondrial ribosomal protein L39

affects expression

ISO

Tamoxifen affects the expression of MRPL39 mRNA

NCBI chr11:37,266,116...37,281,612
Ensembl chr11:37,257,696...37,281,544

G

mitochondrial ribosomal protein L51

affects expression

ISO

Tamoxifen affects the expression of MRPL51 mRNA

NCBI chr 4:159,677,988...159,681,650
Ensembl chr 4:159,677,827...159,681,641

G

mitochondrial ribosomal protein L57

affects expression

ISO

Tamoxifen affects the expression of MRPL57 mRNA

NCBI chr15:36,086,457...36,087,319
Ensembl chr15:36,086,457...36,087,298

G

mitochondrial ribosomal protein S18B

affects expression

ISO

Tamoxifen affects the expression of MRPS18B mRNA

NCBI chr20:2,842,978...2,849,065
Ensembl chr20:2,842,528...2,849,065

G

mitochondrial ribosomal protein S23

affects expression

ISO

Tamoxifen affects the expression of MRPS23 mRNA

NCBI chr10:73,494,417...73,503,996
Ensembl chr10:73,495,702...73,503,543

G

mitochondrial ribosomal protein S25

affects expression

ISO

Tamoxifen affects the expression of MRPS25 mRNA

NCBI chr 4:126,225,449...126,237,212
Ensembl chr 4:126,225,450...126,237,373

G

mitochondrial ribosomal protein S31

affects expression

ISO

Tamoxifen affects the expression of MRPS31 mRNA

NCBI chr16:76,303,807...76,332,970
Ensembl chr16:76,301,645...76,333,065

G

mitochondrial ribosomal protein S6

affects expression

ISO

Tamoxifen affects the expression of MRPS6 mRNA

NCBI chr11:44,778,667...44,834,420
Ensembl chr11:44,781,554...44,834,962

G

microseminoprotein, beta

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of MSMB mRNA

NCBI chr16:7,372,803...7,393,406
Ensembl chr16:7,372,819...7,393,405

G

methylsterol monooxygenase 1

affects expression
decreases expression

ISO

Tamoxifen affects the expression of MSMO1 mRNA
Tamoxifen results in decreased expression of MSMO1 mRNA

PMID:17555576 PMID:20937368 PMID:25123088

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445

G

macrophage stimulating 1

increases expression

ISO

Tamoxifen results in increased expression of MST1 mRNA

NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015

G

metallothionein 1A

multiple interactions
affects expression

ISO

Tamoxifen inhibits the reaction [bisphenol A inhibits the reaction [Cadmium results in increased expression of MT1 protein]]
Tamoxifen affects the expression of MT1 mRNA

PMID:11771854 PMID:17555576 PMID:20937368

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

affects expression

ISO

Tamoxifen affects the expression of MT2 mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

methylthioadenosine phosphorylase

affects expression

ISO

Tamoxifen affects the expression of MTAP mRNA

NCBI chr 5:108,990,270...109,036,494
Ensembl chr 5:108,988,830...109,055,214

G

mitochondrial transcription termination factor 4

affects expression

ISO

Tamoxifen affects the expression of MTERF4 mRNA

NCBI chr 9:101,281,560...101,286,236
Ensembl chr 9:101,281,543...101,286,259

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

affects expression

ISO

Tamoxifen affects the expression of MTHFD1L mRNA

NCBI chr 1:42,849,424...43,038,313
Ensembl chr 1:42,849,374...43,038,309

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

affects expression

ISO

Tamoxifen affects the expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350

G

methylenetetrahydrofolate reductase

decreases expression
increases expression

ISO

Tamoxifen results in decreased expression of MTHFR mRNA
Tamoxifen results in increased expression of MTHFR mRNA

PMID:15849065 PMID:25123088

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

myotubularin related protein 2

increases expression

ISO

Tamoxifen results in increased expression of MTMR2 mRNA

NCBI chr 8:18,899,303...18,949,767
Ensembl chr 8:18,928,126...18,949,766

G

mechanistic target of rapamycin kinase

decreases activity
affects expression
multiple interactions

ISO

Tamoxifen results in decreased activity of MTOR protein
Tamoxifen affects the expression of MTOR mRNA
[Tamoxifen results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein

PMID:17555576 PMID:19931998

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MTSS I-BAR domain containing 1

affects expression

ISO

Tamoxifen affects the expression of MTSS1 mRNA

NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:92,378,238...92,517,303

G

Metaxin 1

affects expression

ISO

Tamoxifen affects the expression of MTX1 mRNA

NCBI chr 2:176,913,225...176,919,148
Ensembl chr 2:176,913,225...176,918,824

G

mucin 1, cell surface associated

affects response to substance

ISO

MUC1 protein affects the susceptibility to Tamoxifen

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491

G

musculoskeletal, embryonic nuclear protein 1

affects expression

ISO

Tamoxifen affects the expression of MUSTN1 mRNA

NCBI chr16:6,079,355...6,081,608
Ensembl chr16:6,079,277...6,081,586

G

mutY DNA glycosylase

affects expression

ISO

Tamoxifen affects the expression of MUTYH mRNA

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:135,517,695...135,522,776

G

mevalonate diphosphate decarboxylase

affects expression

ISO

Tamoxifen affects the expression of MVD mRNA

NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366

G

MX dynamin like GTPase 1

increases expression

ISO

Tamoxifen results in increased expression of MX1 mRNA

NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904

G

MAX interactor 1, dimerization protein

affects expression

ISO

Tamoxifen affects the expression of MXI1 mRNA

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:262,328,875...262,389,036

G

MYB proto-oncogene, transcription factor

affects expression

ISO

Tamoxifen affects the expression of MYB mRNA

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYB proto-oncogene like 2

affects expression

ISO

Tamoxifen affects the expression of MYBL2 mRNA

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:172,116,550...172,153,221

G

myosin binding protein C2

affects expression

ISO

Tamoxifen affects the expression of MYBPC2 mRNA

NCBI chr 1:104,130,642...104,154,101
Ensembl chr 1:104,131,323...104,154,101

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
increases activity
decreases expression
affects expression

ISO
EXP

benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]]; BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of MYC mRNA]; Tamoxifen inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYC mRNA]; Tamoxifen promotes the reaction [AG 1879 results in decreased expression of MYC protein]; Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]
Tamoxifen results in increased expression of MYC mRNA
[Tamoxifen results in increased activity of AKT1 protein] which results in increased activity of MYC protein
Tamoxifen results in decreased expression of MYC mRNA; Tamoxifen results in decreased expression of MYC protein
Tamoxifen affects the expression of MYC mRNA

PMID:12841865 PMID:14699072 PMID:16051634 PMID:17157789 PMID:17186241 More...

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

Myc binding protein

increases expression

ISO

Tamoxifen results in increased expression of MYCBP mRNA

NCBI chr 5:141,420,727...141,427,938
Ensembl chr 5:141,420,707...141,430,681

G

myeloid-derived growth factor

affects expression

ISO

Tamoxifen affects the expression of MYDGF mRNA

NCBI chr 9:1,086,825...1,095,968
Ensembl chr 9:1,086,825...1,095,968

G

MYG1 exonuclease

affects expression

ISO

Tamoxifen affects the expression of MYG1 mRNA

NCBI chr 7:135,335,364...135,342,567
Ensembl chr 7:135,335,334...135,346,740

G

myosin heavy chain 10

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYH10 protein]

NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036

G

myosin heavy chain 6

affects expression

ISO

Tamoxifen affects the expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

affects expression

ISO

Tamoxifen affects the expression of MYH7 mRNA

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin, light chain 1

affects expression

ISO

Tamoxifen affects the expression of MYL1 mRNA

Ensembl chr 9:75,887,227...75,907,971

G

myosin light chain 7

affects expression
increases expression

ISO

Tamoxifen affects the expression of MYL7 mRNA
Tamoxifen results in increased expression of MYL7 mRNA

PMID:17555576 PMID:25123088

NCBI chr14:84,994,644...84,997,173
Ensembl chr14:84,993,736...84,997,372

G

myosin XVIIIa

affects expression

ISO

Tamoxifen affects the expression of MYO18A mRNA

NCBI chr10:63,152,303...63,253,543
Ensembl chr10:63,152,103...63,253,543

G

myosin 1C

affects expression

ISO

Tamoxifen affects the expression of MYO1C mRNA

NCBI chr10:60,996,642...61,019,022
Ensembl chr10:60,996,638...61,019,022

G

myosin VA

increases expression
multiple interactions

ISO

Tamoxifen results in increased expression of MYO5A protein
[Tretinoin co-treated with Tamoxifen] results in increased expression of MYO5A protein

NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:84,692,910...84,856,265

G

myosin Vb

decreases expression

ISO

Tamoxifen results in decreased expression of MYO5B mRNA

NCBI chr18:70,313,717...70,613,918
Ensembl chr18:70,311,990...70,613,918

G

myosin VIIb

affects expression

ISO

Tamoxifen affects the expression of MYO7B mRNA

NCBI chr18:23,862,533...23,944,081
Ensembl chr18:23,862,533...23,944,049

G

myogenic differentiation 1

decreases expression

ISO

Tamoxifen results in decreased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

myomesin 2

increases expression

ISO

Tamoxifen results in increased expression of MYOM2 mRNA

NCBI chr16:81,222,467...81,295,025
Ensembl chr16:81,221,938...81,295,162

G

myomesin 3

increases expression

ISO

Tamoxifen results in increased expression of MYOM3 mRNA

NCBI chr 5:153,276,306...153,326,847
Ensembl chr 5:153,276,261...153,326,839

G

myozenin 2

affects expression

ISO

Tamoxifen affects the expression of MYOZ2 mRNA

NCBI chr 2:213,826,052...213,852,778
Ensembl chr 2:213,826,052...213,852,914

G

myosin VIIA and Rab interacting protein

increases expression

ISO

Tamoxifen results in increased expression of MYRIP mRNA

NCBI chr 8:128,895,371...129,062,420
Ensembl chr 8:128,895,371...129,062,420

G

myelin transcription factor 1-like

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA

NCBI chr 6:51,892,858...52,291,830
Ensembl chr 6:52,155,754...52,291,828

G

NEDD4 binding protein 2-like 1

affects expression

ISO

Tamoxifen affects the expression of N4BP2L1 mRNA

NCBI chr12:4,938,199...4,965,003
Ensembl chr12:4,927,142...4,963,045

G

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

affects expression

ISO

Tamoxifen affects the expression of NAA16 mRNA

NCBI chr15:61,120,704...61,179,979
Ensembl chr15:61,120,704...61,180,146

G

N-acetylated alpha-linked acidic dipeptidase 2

affects expression

ISO

Tamoxifen affects the expression of NAALAD2 mRNA

NCBI chr 8:23,682,499...23,756,066
Ensembl chr 8:23,683,395...23,756,060

G

Ngfi-A binding protein 1

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of NAB1 mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of NAB1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:56,545,547...56,585,045
Ensembl chr 9:56,545,729...56,614,210

G

Ngfi-A binding protein 2

affects expression

ISO

Tamoxifen affects the expression of NAB2 mRNA

NCBI chr 7:65,382,863...65,389,527
Ensembl chr 7:65,382,863...65,389,255

G

nucleic acid binding protein 1

affects expression

ISO

Tamoxifen affects the expression of NABP1 mRNA

NCBI chr 9:57,570,326...57,625,926
Ensembl chr 9:57,618,505...57,626,052

G

NAD kinase

decreases expression

ISO

Tamoxifen results in decreased expression of NADK mRNA

NCBI chr 5:171,427,973...171,458,586
Ensembl chr 5:171,428,000...171,458,579

G

nicotinamide phosphoribosyltransferase

affects expression

ISO

Tamoxifen affects the expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

N-acetylneuraminate synthase

decreases expression
affects expression
multiple interactions

ISO

Tamoxifen results in decreased expression of NANS protein
Tamoxifen affects the expression of NANS mRNA
[Tretinoin co-treated with Tamoxifen] results in decreased expression of NANS protein

PMID:17098229 PMID:17555576

NCBI chr 5:65,575,970...65,593,164
Ensembl chr 5:65,576,015...65,610,547

G

NSF attachment protein alpha

affects expression

ISO

Tamoxifen affects the expression of NAPA mRNA

NCBI chr 1:85,915,088...85,934,054
Ensembl chr 1:85,915,119...85,934,053

G

N-acetyltransferase 1

decreases response to substance

ISO

NAT1 protein results in decreased susceptibility to Tamoxifen

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527

G

N-acetyltransferase 2

decreases activity

ISO

Tamoxifen results in decreased activity of NAT2 protein

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304

G

N-acetyltransferase 8

increases expression
affects expression

ISO

Tamoxifen results in increased expression of NAT8 mRNA
Tamoxifen affects the expression of NAT8 mRNA

PMID:17555576 PMID:25123088

NCBI chr 4:119,836,986...119,837,764
Ensembl chr 4:119,835,645...119,843,159

G

N-acetyltransferase 8 (GCN5-related) family member 1

decreases expression

ISO

Tamoxifen results in decreased expression of NAT8F1 mRNA

NCBI chr 4:119,893,672...119,900,357
Ensembl chr 4:119,886,460...119,916,005

G

N-acetyltransferase 8 (GCN5-related) family member 5

affects expression
increases expression

ISO

Tamoxifen affects the expression of NAT8F5 mRNA
Tamoxifen results in increased expression of NAT8F5 mRNA

PMID:20937368 PMID:25123088

NCBI chr 4:119,817,788...119,842,503
Ensembl chr 4:119,816,735...119,863,953

G

N-acetyltransferase domain containing 1

decreases expression

ISO

Tamoxifen results in decreased expression of NATD1 mRNA

NCBI chr10:46,079,650...46,089,829
Ensembl chr10:46,079,653...46,089,829

G

neuron navigator 2

multiple interactions
decreases expression
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA
Tamoxifen results in decreased expression of NAV2 mRNA
Tamoxifen affects the expression of NAV2 mRNA

PMID:19059307 PMID:20937368 PMID:25123088

NCBI chr 1:107,799,968...108,458,546
Ensembl chr 1:107,805,096...108,458,546

G

NBR1, autophagy cargo receptor

affects expression

ISO

Tamoxifen affects the expression of NBR1 mRNA

NCBI chr10:86,978,024...87,006,664
Ensembl chr10:86,977,885...87,007,012

G

neural cell adhesion molecule 1

affects expression

ISO

Tamoxifen affects the expression of NCAM1 mRNA

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971

G

non-SMC condensin II complex, subunit G2

affects expression

ISO

Tamoxifen affects the expression of NCAPG2 mRNA

NCBI chr 6:143,484,651...143,561,850
Ensembl chr 6:143,485,944...143,560,249

G

neutrophil cytosolic factor 2

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of NCF2 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA

PMID:14699072 PMID:19059307

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

neutrophil cytosolic factor 4

affects expression

ISO

Tamoxifen affects the expression of NCF4 mRNA

NCBI chr 7:111,705,926...111,723,893
Ensembl chr 7:111,706,520...111,723,898

G

nuclear receptor coactivator 1

multiple interactions
increases expression

ISO
EXP

[NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifen; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA1 protein]
Tamoxifen results in increased expression of NCOA1 mRNA
Tamoxifen inhibits the reaction [ESR2 protein binds to NCOA1 protein]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]

PMID:19059307 PMID:19432593 PMID:19460436 PMID:20332105 PMID:20332317 More...

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

nuclear receptor coactivator 2

multiple interactions
increases expression

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA2 protein]; Tamoxifen promotes the reaction [NCOA2 protein binds to KLRC3 gene]
Tamoxifen results in increased expression of NCOA2 mRNA; Tamoxifen results in increased expression of NCOA2 protein

PMID:16739346 PMID:17395694 PMID:20332317 PMID:23665804

NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776

G

nuclear receptor coactivator 3

multiple interactions
increases expression
increases phosphorylation
decreases response to substance

ISO

benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; Tamoxifen promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]; Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]; Tamoxifen promotes the reaction [NCOA3 protein binds to KLRC3 gene]
Tamoxifen results in increased expression of NCOA3 mRNA; Tamoxifen results in increased expression of NCOA3 protein
Tamoxifen results in increased phosphorylation of NCOA3 protein
NCOA3 results in decreased susceptibility to Tamoxifen

PMID:17157789 PMID:17395694 PMID:18997820 PMID:20215421 PMID:20332317 More...

NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631

G

nuclear receptor coactivator 4

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of NCOA4 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA

PMID:14699072 PMID:17555576 PMID:19059307

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840

G

nuclear receptor coactivator 6

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA6 protein]

NCBI chr 3:164,351,062...164,422,079
Ensembl chr 3:164,351,062...164,421,991

G

nuclear receptor co-repressor 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [[ESR1 protein binds to NCOR1 protein] which binds to TFF1 promoter]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR1 protein]; Tamoxifen promotes the reaction [NCOR1 protein binds to TFF1 promoter]; Tamoxifen promotes the reaction [NCOR1 protein binds to TFF2 promoter]

PMID:17157789 PMID:19858209 PMID:20696891 PMID:23665804

NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350

G

nuclear receptor co-repressor 2

multiple interactions
decreases expression

ISO

BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]; BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]; NCOR2 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR2 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]; Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]; Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]; Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]; Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]; U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]; U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]]; U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]]
Tamoxifen results in decreased expression of NCOR2 mRNA

PMID:18997820 PMID:19432593 PMID:20406620 PMID:23665804

NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612

G

N-myc downstream regulated 1

affects expression
decreases expression

ISO

Tamoxifen affects the expression of NDRG1 mRNA
Tamoxifen results in decreased expression of NDRG1 mRNA

PMID:20937368 PMID:25123088

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913

G

NDRG family member 2

affects expression

ISO

Tamoxifen affects the expression of NDRG2 mRNA

NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125

G

NDRG family member 4

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA

NCBI chr19:9,357,470...9,393,465
Ensembl chr19:9,357,470...9,392,972

G

nuclear paraspeckle assembly transcript 1

affects expression

ISO

Tamoxifen affects the expression of NEAT1 mRNA

NCBI chr 1:212,507,512...212,568,055

G

nectin cell adhesion molecule 1

affects expression

ISO

Tamoxifen affects the expression of NECTIN1 mRNA

NCBI chr 8:52,998,662...53,061,745
Ensembl chr 8:52,998,662...53,086,664

G

nectin cell adhesion molecule 2

affects expression

ISO

Tamoxifen affects the expression of NECTIN2 mRNA

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305

G

nectin cell adhesion molecule 3

decreases expression

ISO

Tamoxifen results in decreased expression of NECTIN3 mRNA

NCBI chr11:67,825,296...67,931,999
Ensembl chr11:67,827,137...67,871,383

G

NEDD1 gamma-tubulin ring complex targeting factor

affects expression

ISO

Tamoxifen affects the expression of NEDD1 mRNA

NCBI chr 7:29,120,200...29,161,634
Ensembl chr 7:29,120,200...29,161,634

G

neural precursor cell expressed, developmentally down-regulated 9

increases expression

ISO

Tamoxifen results in increased expression of NEDD9 mRNA

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668

G

neurofilament heavy chain

affects expression

ISO

Tamoxifen affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

NIMA-related kinase 4

affects expression

ISO

Tamoxifen affects the expression of NEK4 mRNA

NCBI chr16:6,151,292...6,200,280
Ensembl chr16:6,151,368...6,198,450

G

NIMA-related kinase 6

affects expression

ISO

Tamoxifen affects the expression of NEK6 mRNA

NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:42,693,971...42,767,773

G

NIMA-related kinase 7

multiple interactions
affects expression

ISO

ESR1 protein affects the reaction [Tamoxifen results in decreased expression of NEK7 mRNA]
Tamoxifen affects the expression of NEK7 mRNA

NCBI chr13:52,573,730...52,700,869
Ensembl chr13:52,573,730...52,700,823

G

negative elongation factor complex member B

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to NELFB protein]

NCBI chr 3:28,409,045...28,425,564
Ensembl chr 3:28,409,050...28,425,564

G

negative elongation factor complex member C/D

affects expression

ISO

Tamoxifen affects the expression of NELFCD mRNA

NCBI chr 3:183,631,968...183,643,088
Ensembl chr 3:183,631,968...183,643,088

G

negative elongation factor complex member E

increases expression

ISO

Tamoxifen results in increased expression of NELFE mRNA

NCBI chr20:3,981,259...3,987,016
Ensembl chr20:3,981,261...3,986,922

G

neuraminidase 2

affects expression
decreases expression

ISO

Tamoxifen affects the expression of NEU2 mRNA
Tamoxifen results in decreased expression of NEU2 mRNA

PMID:20937368 PMID:25123088

NCBI chr 9:95,666,338...95,715,209
Ensembl chr 9:95,696,507...95,715,208

G

nexilin (F actin binding protein)

affects expression

ISO

Tamoxifen affects the expression of NEXN mRNA

NCBI chr 2:243,846,736...243,878,268
Ensembl chr 2:243,846,433...243,887,114

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

affects expression

ISO

Tamoxifen affects the expression of NF2 mRNA

NCBI chr14:83,850,894...83,934,263
Ensembl chr14:83,850,894...83,934,151

G

nuclear factor of activated T-cells 1

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA
Tamoxifen results in increased expression of NFATC1 mRNA

PMID:19031437 PMID:19059307

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

nuclear factor, erythroid 2

decreases expression

ISO

Tamoxifen results in decreased expression of NFE2 mRNA

NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:136,261,236...136,268,585

G

nuclear factor I/C

affects expression

ISO

Tamoxifen affects the expression of NFIC mRNA

NCBI chr 7:8,928,423...8,963,455
Ensembl chr 7:8,904,117...8,963,409

G

nuclear factor, interleukin 3 regulated

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of NFIL3 mRNA
[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA

PMID:14699072 PMID:19059307 PMID:20937368

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

nuclear factor I X

decreases expression

ISO

Tamoxifen results in decreased expression of NFIX mRNA

NCBI chr19:40,259,873...40,356,966
Ensembl chr19:40,260,084...40,353,092

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

ISO

Tamoxifen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Tamoxifen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Tamoxifen results in increased expression of NFKB1 mRNA

PMID:15489888 PMID:15604281

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions
decreases expression
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA; Tamoxifen inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
Tamoxifen results in decreased expression of NFKBIA mRNA
Tamoxifen affects the expression of NFKBIA mRNA

PMID:14699072 PMID:15489888 PMID:16298037 PMID:19059307

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor beta

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to NFKBIB protein]

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

NFKB inhibitor epsilon

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

NFKB inhibitor zeta

affects expression

ISO

Tamoxifen affects the expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767

G

neuronal guanine nucleotide exchange factor

affects expression

ISO

Tamoxifen affects the expression of NGEF mRNA

NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:95,594,823...95,692,251

G

NHERF family PDZ scaffold protein 1

affects expression

ISO

Tamoxifen affects the expression of NHERF1 mRNA

NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579

G

niban apoptosis regulator 2

increases expression

ISO

Tamoxifen results in increased expression of NIBAN2 mRNA

NCBI chr 3:36,572,356...36,621,968
Ensembl chr 3:36,572,377...36,621,967

G

nidogen 2

affects expression

ISO

Tamoxifen affects the expression of NID2 mRNA

NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,506,756...4,562,949

G

nucleolar protein interacting with the FHA domain of MKI67

affects expression

ISO

Tamoxifen affects the expression of NIFK mRNA

NCBI chr13:31,946,119...31,955,950
Ensembl chr13:31,946,108...31,959,561

G

NIM1 serine/threonine protein kinase

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of NIM1K mRNA

NCBI chr 2:53,403,467...53,451,248
Ensembl chr 2:53,403,473...53,419,656

G

ninjurin 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

NKD inhibitor of WNT signaling pathway 1

increases expression

ISO

Tamoxifen results in increased expression of NKD1 mRNA

NCBI chr19:34,649,803...34,722,846

G

natural killer cell granule protein 7

multiple interactions

ISO

[Allura Red AC Dye co-treated with Tamoxifen] results in increased expression of NKG7 mRNA

NCBI chr 1:102,981,497...102,982,564
Ensembl chr 1:102,981,450...102,982,562

G

NFKB inhibitor interacting Ras-like 2

affects expression

ISO

Tamoxifen affects the expression of NKIRAS2 mRNA

NCBI chr10:86,055,029...86,062,398
Ensembl chr10:86,058,285...86,062,392

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 1

affects expression

ISO

Tamoxifen affects the expression of NME1 mRNA

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

NME/NM23 nucleoside diphosphate kinase 6

affects expression

ISO

Tamoxifen affects the expression of NME6 mRNA

NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:118,711,036...118,718,288

G

NME/NM23 family member 8

affects expression

ISO

Tamoxifen affects the expression of NME8 mRNA

NCBI chr17:49,932,861...50,000,610
Ensembl chr17:49,932,860...50,000,608

G

N-myc (and STAT) interactor

affects expression

ISO

Tamoxifen affects the expression of NMI mRNA

NCBI chr 3:56,824,778...56,848,891
Ensembl chr 3:56,811,314...56,848,717

G

neuronatin

affects expression

ISO

Tamoxifen affects the expression of NNAT mRNA

NCBI chr 3:166,646,373...166,648,845
Ensembl chr 3:166,646,384...166,649,086

G

nicotinamide N-methyltransferase

multiple interactions
affects expression

ISO

ESR2 protein affects the reaction [Tamoxifen results in increased expression of NNMT mRNA]
Tamoxifen affects the expression of NNMT mRNA

PMID:14699072 PMID:17555576 PMID:20937368

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174

G

nitric oxide associated 1

increases activity
multiple interactions

ISO
EXP

Tamoxifen results in increased activity of NOA1 protein
[Tamoxifen results in increased abundance of Calcium] which results in increased activity of NOA1 protein; [Tamoxifen results in increased activity of NOA1 protein] which results in decreased activity of OXCT1 protein; [Tamoxifen results in increased activity of NOA1 protein] which results in increased abundance of Peroxynitrous Acid

NCBI chr14:31,189,570...31,205,600
Ensembl chr14:31,188,978...31,205,599

G

nocturnin

affects expression

ISO

Tamoxifen affects the expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282

G

nucleotide-binding oligomerization domain containing 1

increases expression

ISO

Tamoxifen results in increased expression of NOD1 mRNA

NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:85,391,151...85,441,674

G

nucleolar protein 3

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of NOL3 mRNA

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

Nodal modulator 1

affects expression

ISO

Tamoxifen affects the expression of NOMO1 mRNA

PMID:17555576 PMID:20937368

NCBI chr 1:105,641,867...105,692,708
Ensembl chr 1:105,641,879...105,692,707

G

NOP58 ribonucleoprotein

affects expression

ISO

Tamoxifen affects the expression of NOL5 mRNA

NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909

G

nitric oxide synthase 1

multiple interactions
increases expression

EXP

Tamoxifen binds to and results in decreased activity of NOS1 protein; Tamoxifen inhibits the reaction [CALM1 protein binds to NOS1 protein]; zinc chloride inhibits the reaction [Tamoxifen results in increased expression of NOS1 protein]

PMID:17098364 PMID:31532279

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

multiple interactions
decreases expression
increases expression

ISO

Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 mRNA]]; Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 mRNA]
Tamoxifen inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]
Tamoxifen results in decreased expression of NOS2 protein
Tamoxifen results in increased expression of NOS2 protein

PMID:9742967 PMID:15256495 PMID:17873880 PMID:20225760 PMID:20559769

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 1

decreases expression
multiple interactions

EXP

Tamoxifen results in decreased expression of NOTCH1 protein
[Tamoxifen results in increased expression of MIR34A mRNA] which results in decreased expression of NOTCH1 protein

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

notch receptor 3

affects expression

ISO

Tamoxifen affects the expression of NOTCH3 mRNA

NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,784,272...11,834,778

G

NOVA alternative splicing regulator 1

decreases expression

ISO

Tamoxifen results in decreased expression of NOVA1 mRNA

NCBI chr 6:69,506,983...69,632,437
Ensembl chr 6:69,506,983...69,632,437

G

NPHS2 stomatin family member, podocin

multiple interactions

ISO

Tamoxifen inhibits the reaction [bisphenol A results in decreased expression of NPHS2 protein]

NCBI chr13:70,993,622...71,011,585
Ensembl chr13:70,999,186...71,011,572

G

nucleophosmin/nucleoplasmin, 3

affects expression

ISO

Tamoxifen affects the expression of NPM3 mRNA

NCBI chr 1:254,544,664...254,546,649
Ensembl chr 1:254,544,664...254,546,649

G

natriuretic peptide receptor 2

affects expression
increases expression
multiple interactions

ISO

Tamoxifen affects the expression of NPR2 mRNA
Tamoxifen results in increased expression of NPR2 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA

PMID:14699072 PMID:19059307 PMID:25123088

NCBI chr 5:62,678,197...62,697,360
Ensembl chr 5:62,678,367...62,697,343

G

neuropeptide Y receptor Y1

affects expression

ISO

Tamoxifen affects the expression of NPY1R mRNA

NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387

G

NAD(P)H quinone dehydrogenase 1

affects expression

ISO

Tamoxifen affects the expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 0, group B, member 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B1 protein]

NCBI chr X:54,707,658...54,711,786
Ensembl chr X:54,707,639...54,712,083

G

nuclear receptor subfamily 0, group B, member 2

affects expression
multiple interactions
increases expression

ISO

Tamoxifen affects the expression of NR0B2 mRNA
Tamoxifen inhibits the reaction [ESR1 protein binds to NR0B2 protein]
Tamoxifen results in increased expression of NR0B2 mRNA

PMID:15342952 PMID:17175557 PMID:17555576 PMID:20937368 PMID:23665804

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group D, member 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA
Tamoxifen affects the expression of NR1D1 mRNA

PMID:19059307 PMID:20937368

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 1, group D, member 2

affects expression

ISO

Tamoxifen affects the expression of NR1D2 mRNA

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

EXP

Tamoxifen results in decreased expression of NR1H4 mRNA

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
decreases expression
increases activity

ISO
EXP

[SR 12813 results in increased activity of NR1I2 protein] which results in decreased susceptibility to Tamoxifen; [Tamoxifen results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Tamoxifen results in increased expression of ABCB1 protein]; Tamoxifen binds to and results in increased activity of NR1I2 protein
Tamoxifen results in decreased expression of NR1I2 mRNA

PMID:16054614 PMID:18839173 PMID:19746521 PMID:20041327 PMID:27765674 More...

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

affects expression
decreases expression

ISO

Tamoxifen affects the expression of NR1I3 mRNA
Tamoxifen results in decreased expression of NR1I3 mRNA

PMID:17555576 PMID:25123088

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 2, group C, member 1

affects expression

ISO

Tamoxifen affects the expression of NR2C1 mRNA

NCBI chr 7:30,602,338...30,655,610
Ensembl chr 7:30,603,018...30,658,349

G

nuclear receptor subfamily 2, group F, member 1

decreases activity
decreases expression

ISO

Tamoxifen results in decreased activity of NR2F1 protein
Tamoxifen results in decreased expression of NR2F1 mRNA

PMID:20937368 PMID:29974145

NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924

G

nuclear receptor subfamily 2, group F, member 6

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA

NCBI chr16:18,080,003...18,087,449
Ensembl chr16:18,080,003...18,087,449

G

nuclear receptor subfamily 3, group C, member 1

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of NR3C1 mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA

PMID:17555576 PMID:19059307

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

affects expression

ISO

Tamoxifen affects the expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

increases expression

ISO

Tamoxifen results in increased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

nuclear receptor subfamily 5, group A, member 1

increases activity
increases phosphorylation

ISO

Tamoxifen analog results in increased activity of NR5A1 protein
Tamoxifen analog results in increased phosphorylation of NR5A1 protein

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

neurotrophin receptor associated death domain

affects expression

ISO

Tamoxifen affects the expression of NRADD mRNA

NCBI chr 8:119,478,055...119,481,336
Ensembl chr 8:119,477,240...119,481,214

G

Notch-regulated ankyrin repeat protein

increases expression

ISO

Tamoxifen results in increased expression of NRARP mRNA

NCBI chr 3:28,390,745...28,393,299
Ensembl chr 3:28,390,733...28,393,453

G

nuclear receptor binding protein 1

affects expression

ISO

Tamoxifen affects the expression of NRBP1 mRNA

NCBI chr 6:30,842,606...30,853,177
Ensembl chr 6:30,842,609...30,853,108

G

nuclear receptor binding protein 2

affects expression

ISO

Tamoxifen affects the expression of NRBP2 mRNA

NCBI chr 7:109,679,330...109,685,656
Ensembl chr 7:109,679,330...109,685,588

G

neuronal regeneration related protein

affects expression

ISO

Tamoxifen affects the expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

neuregulin 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neuregulin 4

affects expression

ISO

Tamoxifen affects the expression of NRG4 mRNA

NCBI chr 8:64,483,559...64,555,671
Ensembl chr 8:64,488,722...64,573,439

G

nuclear receptor interacting protein 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to NRIP1 protein]

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

nurim

affects expression

ISO

Tamoxifen affects the expression of NRM mRNA

NCBI chr20:2,893,126...2,897,725
Ensembl chr20:2,882,369...2,896,605

G

neuropilin 1

affects expression

ISO

Tamoxifen affects the expression of NRP1 mRNA

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

neuropilin 2

increases expression

ISO

Tamoxifen results in increased expression of NRP2 mRNA

NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871

G

neuronal vesicle trafficking associated 2

affects expression

ISO

Tamoxifen affects the expression of NSG2 mRNA

NCBI chr10:16,106,073...16,165,915
Ensembl chr10:16,147,325...16,165,915

G

NOP2/Sun RNA methyltransferase 6

affects expression

ISO

Tamoxifen affects the expression of NSUN6 mRNA

NCBI chr17:82,820,938...82,864,140
Ensembl chr17:82,820,941...82,858,539

G

5'-nucleotidase domain containing 2

affects expression

ISO

Tamoxifen affects the expression of NT5DC2 mRNA

NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,328,523...6,336,980

G

N-terminal asparagine amidase

affects expression

ISO

Tamoxifen affects the expression of NTAN1 mRNA

NCBI chr10:2,618,239...2,633,185
Ensembl chr10:2,618,235...2,633,810

G

neurotrophic receptor tyrosine kinase 1

increases expression

ISO

Tamoxifen results in increased expression of NTRK1 mRNA

NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787

G

NUAK family kinase 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA

NCBI chr 7:21,217,729...21,289,608
Ensembl chr 7:21,217,681...21,289,354

G

nucleobindin 1

affects expression

ISO

Tamoxifen affects the expression of NUCB1 mRNA

NCBI chr 1:105,104,793...105,135,730
Ensembl chr 1:105,104,793...105,135,837

G

nucleobindin 2

increases expression

ISO

Tamoxifen results in increased expression of NUCB2 mRNA

NCBI chr 1:180,185,121...180,221,644
Ensembl chr 1:180,199,551...180,230,116

G

nuclear casein kinase and cyclin-dependent kinase substrate 1

affects expression

ISO

Tamoxifen affects the expression of NUCKS1 mRNA

NCBI chr13:45,897,275...45,926,491
Ensembl chr13:45,897,248...45,923,101

G

nuclear distribution C, dynein complex regulator

affects expression

ISO

Tamoxifen affects the expression of NUDC mRNA

NCBI chr 5:151,041,878...151,055,260
Ensembl chr 5:151,041,875...151,055,260

G

nudix hydrolase 13

affects expression

ISO

Tamoxifen affects the expression of NUDT13 mRNA

NCBI chr15:4,050,979...4,071,605
Ensembl chr15:4,050,980...4,071,476

G

nudix hydrolase 21

affects expression

ISO

Tamoxifen affects the expression of NUDT21 mRNA

NCBI chr19:10,980,797...10,996,903
Ensembl chr19:10,980,158...10,999,754

G

nudix hydrolase 6

affects expression

ISO

Tamoxifen affects the expression of NUDT6 mRNA

NCBI chr 2:122,218,031...122,234,488
Ensembl chr 2:122,217,861...122,234,344

G

nucleoporin 35

affects expression

ISO

Tamoxifen affects the expression of NUP35 mRNA

NCBI chr 3:85,965,907...85,991,659
Ensembl chr 3:85,945,080...85,992,027

G

nucleoporin 42

decreases expression

ISO

Tamoxifen results in decreased expression of NUP42 mRNA

NCBI chr 4:11,877,957...11,894,991
Ensembl chr 4:11,877,957...11,894,991

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

Tamoxifen results in increased expression of NUPR1 mRNA

PMID:17175557 PMID:17567588

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

NUS1 dehydrodolichyl diphosphate synthase subunit

affects expression

ISO

Tamoxifen affects the expression of NUS1 mRNA

NCBI chr20:32,354,519...32,381,265
Ensembl chr20:32,354,439...32,381,264

G

nucleolar and spindle associated protein 1

affects expression

ISO

Tamoxifen affects the expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:127,057,265...127,087,237

G

2'-5' oligoadenylate synthetase 1A

increases expression

ISO

Tamoxifen results in increased expression of OAS1 mRNA

NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128

G

2'-5'-oligoadenylate synthetase 3

increases expression

ISO

Tamoxifen results in increased expression of OAS3 mRNA

NCBI chr12:41,439,645...41,463,392
Ensembl chr12:41,439,643...41,464,420

G

2'-5'-oligoadenylate synthetase-like

affects expression
decreases expression

ISO

Tamoxifen affects the expression of OASL1 mRNA
Tamoxifen results in decreased expression of OASL1 mRNA

PMID:20937368 PMID:25123088

NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483

G

ornithine aminotransferase

affects expression

ISO

Tamoxifen affects the expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

odorant binding protein 2A

increases expression

ISO

Tamoxifen results in increased expression of OBP2A mRNA

NCBI chr 3:28,904,024...28,907,391
Ensembl chr 3:28,902,876...28,907,389

G

OCIA domain containing 1

affects expression

ISO

Tamoxifen affects the expression of OCIAD1 mRNA

NCBI chr14:35,251,891...35,269,440
Ensembl chr14:35,251,333...35,269,283

G

OCIA domain containing 2

increases expression

ISO

Tamoxifen results in increased expression of OCIAD2 mRNA

NCBI chr14:35,225,291...35,243,306
Ensembl chr14:35,225,255...35,243,311

G

occludin

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of OCLN mRNA

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

ornithine decarboxylase 1

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of ODC1 mRNA
Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

PMID:12628514 PMID:17555576

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

O-GlcNAcase

affects expression

ISO

Tamoxifen affects the expression of OGA mRNA

NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855

G

olfactomedin 1

affects expression

ISO

Tamoxifen affects the expression of OLFM1 mRNA

NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:31,918,573...31,956,260

G

olfactomedin 3

decreases expression

ISO

Tamoxifen results in decreased expression of OLFM3 mRNA

NCBI chr 2:205,417,962...205,640,479
Ensembl chr 2:205,598,959...205,640,479

G

olfactomedin-like 3

affects expression

ISO

Tamoxifen affects the expression of OLFML3 mRNA

NCBI chr 2:193,932,665...193,935,494
Ensembl chr 2:193,932,665...193,935,494

G

oligodendrocyte-myelin glycoprotein

decreases expression

EXP

Tamoxifen results in decreased expression of OMG mRNA

NCBI chr10:64,959,316...64,962,050
Ensembl chr10:64,936,145...64,962,050

G

olfactory marker protein

increases expression

ISO

Tamoxifen results in increased expression of OMP mRNA

NCBI chr 1:161,851,499...161,852,049

G

OPA1, mitochondrial dynamin like GTPase

affects expression

ISO

Tamoxifen affects the expression of OPA1 mRNA

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955

G

5-oxoprolinase (ATP-hydrolysing)

affects expression

ISO

Tamoxifen affects the expression of OPLAH mRNA

NCBI chr 7:109,892,136...109,932,403
Ensembl chr 7:109,891,405...109,915,979

G

opioid receptor, mu 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

optineurin

affects expression

ISO

Tamoxifen affects the expression of OPTN mRNA

NCBI chr17:78,118,847...78,169,543
Ensembl chr17:78,118,866...78,169,543

G

olfactory receptor family 4 subfamily C member 35

decreases expression

ISO

Tamoxifen results in decreased expression of OR4C35 mRNA

NCBI chr 3:96,449,536...96,450,468
Ensembl chr 3:96,449,536...96,450,468

G

ORMDL sphingolipid biosynthesis regulator 3

affects expression

ISO

Tamoxifen affects the expression of ORMDL3 mRNA

NCBI chr10:84,086,317...84,092,673
Ensembl chr10:84,086,317...84,093,548

G

OS9, endoplasmic reticulum lectin

affects expression

ISO

Tamoxifen affects the expression of OS9 mRNA

NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070

G

oxysterol binding protein-like 1A

affects expression

ISO

Tamoxifen affects the expression of OSBPL1A mRNA

NCBI chr18:4,178,734...4,383,511
Ensembl chr18:4,179,631...4,369,421

G

oxysterol binding protein-like 3

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA
Tamoxifen results in increased expression of OSBPL3 mRNA

PMID:19059307 PMID:25123088

NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169

G

oxysterol binding protein-like 5

affects expression

ISO

Tamoxifen affects the expression of OSBPL5 mRNA

NCBI chr 1:208,291,441...208,362,086
Ensembl chr 1:208,291,441...208,362,169

G

oxysterol binding protein-like 7

increases expression

ISO

Tamoxifen results in increased expression of OSBPL7 mRNA

NCBI chr10:82,532,335...82,549,999
Ensembl chr10:82,532,411...82,549,999

G

oxidative stress induced growth inhibitor 1

affects expression

ISO

Tamoxifen affects the expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

oncostatin M receptor

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of OSMR mRNA
[Carbon Tetrachloride co-treated with Tamoxifen] affects the expression of OSMR mRNA

PMID:14699072 PMID:29974145

NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561

G

odd-skipped related transcription factor 1

affects expression

ISO

Tamoxifen affects the expression of OSR1 mRNA

NCBI chr 6:38,088,688...38,100,010
Ensembl chr 6:38,093,011...38,100,021

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA
Tamoxifen affects the expression of OTUB2 mRNA

PMID:17555576 PMID:19059307

NCBI chr 6:128,309,863...128,328,444
Ensembl chr 6:128,299,693...128,328,433

G

OTU deubiquitinase 5

affects expression

ISO

Tamoxifen affects the expression of OTUD5 mRNA

NCBI chr X:17,296,750...17,331,257
Ensembl chr X:17,298,029...17,331,054

G

OXA1L, mitochondrial inner membrane protein

decreases expression

ISO

Tamoxifen results in decreased expression of OXA1L mRNA

NCBI chr15:31,783,725...31,791,353
Ensembl chr15:31,776,063...31,792,354

G

3-oxoacid CoA transferase 1

multiple interactions

EXP

[Tamoxifen results in increased activity of NOA1 protein] which results in decreased activity of OXCT1 protein

NCBI chr 2:54,963,964...55,112,303
Ensembl chr 2:54,963,784...55,112,298

G

3-oxoacid CoA transferase 2B

affects expression

ISO

Tamoxifen affects the expression of OXCT2B mRNA

NCBI chr 5:140,681,746...140,683,500
Ensembl chr 5:140,671,211...140,696,448

G

oxidation resistance 1

affects expression

ISO

Tamoxifen affects the expression of OXR1 mRNA

NCBI chr 7:74,413,609...74,850,487
Ensembl chr 7:74,413,590...74,850,487

G

oxytocin receptor

increases activity

EXP

Tamoxifen results in increased activity of OXTR protein

NCBI chr 4:147,154,374...147,171,723
Ensembl chr 4:147,154,374...147,170,750

G

purinergic receptor P2X 5

decreases expression

ISO

Tamoxifen results in decreased expression of P2RX5 mRNA

NCBI chr10:58,276,329...58,291,108
Ensembl chr10:58,276,257...58,287,935

G

pyrimidinergic receptor P2Y4

decreases expression

ISO

Tamoxifen results in decreased expression of P2RY4 mRNA

NCBI chr X:69,722,604...69,757,726
Ensembl chr X:69,721,753...69,753,510

G

prolyl 4-hydroxylase subunit alpha 1

affects expression

ISO

Tamoxifen affects the expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

prolyl 4-hydroxylase subunit alpha 2

affects expression

ISO

Tamoxifen affects the expression of P4HA2 mRNA

NCBI chr10:38,743,894...38,772,741
Ensembl chr10:38,743,894...38,772,993

G

prolyl 4-hydroxylase subunit beta

affects expression
decreases expression

ISO

Tamoxifen affects the expression of P4HB mRNA
Tamoxifen results in decreased expression of P4HB protein

PMID:17555576 PMID:38779996

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

proliferation-associated 2G4

multiple interactions
affects expression
increases response to substance

ISO

ERBB2 protein inhibits the reaction [PA2G4 protein results in increased susceptibility to Tamoxifen]
Tamoxifen affects the expression of PA2G4 mRNA

PMID:17555576 PMID:20379846

NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:1,569,327...1,576,802

G

protein kinase C and casein kinase substrate in neurons 2

affects expression

ISO

Tamoxifen affects the expression of PACSIN2 mRNA

NCBI chr 7:116,385,571...116,478,609
Ensembl chr 7:116,384,190...116,478,537

G

peptidyl arginine deiminase 2

affects expression

ISO

Tamoxifen affects the expression of PADI2 mRNA

NCBI chr 5:158,492,087...158,534,662
Ensembl chr 5:158,492,066...158,534,662

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2

affects expression

ISO

Tamoxifen affects the expression of PAFAH1B2 mRNA

NCBI chr 8:55,156,778...55,208,800
Ensembl chr 8:55,156,779...55,176,836

G

p21 (RAC1) activated kinase 1

affects response to substance
affects expression

ISO

PAK1 affects the susceptibility to Tamoxifen
Tamoxifen affects the expression of PAK1 mRNA

PMID:17555576 PMID:20179234

NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:161,491,847...161,637,612

G

PAK1 interacting protein 1

affects expression

ISO

Tamoxifen affects the expression of PAK1IP1 mRNA

NCBI chr17:23,947,978...23,959,055
Ensembl chr17:23,939,509...23,959,055

G

p21 (RAC1) activated kinase 4

affects expression

ISO

Tamoxifen affects the expression of PAK4 mRNA

NCBI chr 1:92,977,437...93,016,721
Ensembl chr 1:92,977,437...93,016,721

G

palladin, cytoskeletal associated protein

affects expression
increases expression

ISO

Tamoxifen affects the expression of PALLD mRNA
Tamoxifen results in increased expression of PALLD mRNA

PMID:14699072 PMID:17555576

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:33,238,956...33,632,232

G

protein associated with LIN7 2, MAGUK p55 family member

affects expression

ISO

Tamoxifen affects the expression of PALS2 mRNA

NCBI chr 4:80,504,298...80,584,951
Ensembl chr 4:80,455,657...80,584,950

G

poly(A) specific ribonuclease subunit PAN2

affects expression

ISO

Tamoxifen affects the expression of PAN2 mRNA

NCBI chr 7:1,313,654...1,332,252
Ensembl chr 7:1,313,655...1,332,252

G

poly (ADP-ribose) glycohydrolase

increases expression

ISO

Tamoxifen results in increased expression of PARG mRNA

NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression
increases cleavage

ISO

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein]
Tamoxifen results in decreased expression of PARP1 mRNA

PMID:14645110 PMID:38779996

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

poly (ADP-ribose) polymerase family, member 12

affects expression

ISO

Tamoxifen affects the expression of PARP12 mRNA

NCBI chr 4:68,793,411...68,851,214
Ensembl chr 4:68,806,100...68,850,541

G

poly (ADP-ribose) polymerase family, member 14

affects expression

ISO

Tamoxifen affects the expression of PARP14 mRNA

NCBI chr11:78,408,134...78,440,201
Ensembl chr11:78,408,058...78,440,195

G

poly (ADP-ribose) polymerase family, member 9

affects expression

ISO

Tamoxifen affects the expression of PARP9 mRNA

NCBI chr11:78,286,282...78,320,409
Ensembl chr11:78,286,287...78,320,608

G

PAT1 homolog 1, processing body mRNA decay factor

affects expression

ISO

Tamoxifen affects the expression of PATL1 mRNA

NCBI chr 1:218,255,801...218,287,662
Ensembl chr 1:218,255,848...218,287,657

G

paired box 2

decreases expression

ISO

Tamoxifen results in decreased expression of PAX2 mRNA

NCBI chr 1:253,555,447...253,646,623
Ensembl chr 1:253,555,418...253,645,438

G

PDZ binding kinase

affects expression

ISO

Tamoxifen affects the expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:44,198,544...44,209,570

G

phenazine biosynthesis-like protein domain containing 1

affects expression

ISO

Tamoxifen affects the expression of PBLD mRNA

NCBI chr20:25,549,974...25,565,390
Ensembl chr20:25,549,974...25,565,226

G

PBX homeobox 3

increases expression

ISO

Tamoxifen results in increased expression of PBX3 mRNA

NCBI chr 3:37,886,241...38,079,956
Ensembl chr 3:37,886,687...38,079,895

G

pyruvate carboxylase

affects expression

ISO

Tamoxifen affects the expression of PCX mRNA

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

poly(rC) binding protein 1

affects expression

ISO

Tamoxifen affects the expression of PCBP1 mRNA

PMID:14699072 PMID:17555576

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111

G

poly(rC) binding protein 3

affects expression

ISO

Tamoxifen affects the expression of PCBP3 mRNA

NCBI chr20:11,635,579...11,877,721
Ensembl chr20:11,677,751...11,877,722

G

protocadherin 7

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA

NCBI chr14:56,684,817...57,114,976
Ensembl chr14:56,687,725...57,112,665

G

phosphorylated CTD interacting factor 1

affects expression

ISO

Tamoxifen affects the expression of PCIF1 mRNA

NCBI chr 3:174,033,471...174,046,403
Ensembl chr 3:174,034,675...174,049,395

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

affects expression

ISO

Tamoxifen affects the expression of PCK2 mRNA

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

PCNA clamp associated factor

decreases expression

ISO

Tamoxifen results in decreased expression of PCLAF mRNA

NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:75,315,707...75,328,106

G

proliferating cell nuclear antigen

decreases expression
multiple interactions
affects expression
increases expression

EXP
ISO

Tamoxifen results in decreased expression of PCNA mRNA
Tamoxifen inhibits the reaction [Estradiol results in increased expression of PCNA mRNA]
Tamoxifen affects the expression of PCNA mRNA
Tamoxifen results in increased expression of PCNA mRNA; Tamoxifen results in increased expression of PCNA protein

PMID:8844968 PMID:12602925 PMID:12841865 PMID:17219426 PMID:17555576 More...

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

pericentrin

affects expression

ISO

Tamoxifen affects the expression of PCNT mRNA

NCBI chr20:12,189,767...12,278,179
Ensembl chr20:12,192,353...12,278,178

G

proprotein convertase subtilisin/kexin type 2

affects expression

ISO

Tamoxifen affects the expression of PCSK2 mRNA

NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849

G

proprotein convertase subtilisin/kexin type 6

increases expression

ISO

Tamoxifen results in increased expression of PCSK6 mRNA

NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:128,839,232...129,052,128

G

proprotein convertase subtilisin/kexin type 9

decreases expression

ISO

Tamoxifen results in decreased expression of PCSK9 mRNA

NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507

G

phosphatidylcholine transfer protein

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432

G

prenylcysteine oxidase 1 like

increases expression

ISO

Tamoxifen results in increased expression of PCYOX1L mRNA

NCBI chr18:57,420,971...57,431,632
Ensembl chr18:57,420,977...57,431,632

G

programmed cell death 1

affects expression

ISO

Tamoxifen affects the expression of PDCD1 mRNA

NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270

G

programmed cell death 2

affects expression

ISO

Tamoxifen affects the expression of PDCD2 mRNA

NCBI chr 1:65,158,034...65,163,524
Ensembl chr 1:65,158,034...65,163,524

G

phosphodiesterase 2A

affects expression

ISO

Tamoxifen affects the expression of PDE2A mRNA

NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466

G

phosphodiesterase 4B

affects expression

ISO

Tamoxifen affects the expression of PDE4B mRNA

PMID:14699072 PMID:20937368

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

phosphodiesterase 9A

affects expression

ISO

Tamoxifen affects the expression of PDE9A mRNA

PMID:17555576 PMID:20937368

NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286

G

platelet derived growth factor subunit A

affects expression

ISO

Tamoxifen affects the expression of PDGFA mRNA

NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322

G

platelet derived growth factor receptor alpha

increases expression

ISO

Tamoxifen results in increased expression of PDGFRA mRNA

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516

G

protein disulfide isomerase family A, member 4

affects expression

ISO

Tamoxifen affects the expression of PDIA4 mRNA

NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191

G

pyruvate dehydrogenase kinase 2

affects expression

ISO

Tamoxifen affects the expression of PDK2 mRNA

NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355

G

pyruvate dehydrogenase kinase 4

affects expression
increases expression

ISO

Tamoxifen affects the expression of PDK4 mRNA
Tamoxifen results in increased expression of PDK4 mRNA

PMID:20937368 PMID:25123088

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 1

affects expression

ISO

Tamoxifen affects the expression of PDLIM1 mRNA

NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:248,991,818...249,047,379

G

PDZ and LIM domain 2

affects expression

ISO

Tamoxifen affects the expression of PDLIM2 mRNA

NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958

G

PDZ and LIM domain 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA

NCBI chr16:53,085,020...53,116,495
Ensembl chr16:53,085,020...53,116,217

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of PDP1 mRNA

NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960

G

decaprenyl diphosphate synthase subunit 1

affects expression

ISO

Tamoxifen affects the expression of PDSS1 mRNA

NCBI chr17:89,964,768...90,006,819
Ensembl chr17:89,968,034...90,006,817

G

pyridoxal-dependent decarboxylase domain containing 1

affects expression

ISO

Tamoxifen affects the expression of PDXDC1 mRNA

NCBI chr10:2,528,989...2,620,669
Ensembl chr10:2,532,485...2,620,669

G

pyridoxal kinase

affects expression

ISO

Tamoxifen affects the expression of PDXK mRNA

NCBI chr20:10,209,975...10,232,012
Ensembl chr20:10,209,832...10,233,780

G

prodynorphin

increases expression
multiple interactions

EXP

Tamoxifen results in increased expression of PDYN mRNA; Tamoxifen results in increased expression of PDYN protein alternative form
Tamoxifen inhibits the reaction [Estradiol results in decreased expression of PDYN mRNA]

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

PDZ domain containing 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA]

NCBI chr 2:187,064,995...187,096,348
Ensembl chr 2:187,065,013...187,096,806

G

peroxisomal trans-2-enoyl-CoA reductase

affects expression

ISO

Tamoxifen affects the expression of PECR mRNA

NCBI chr 9:81,347,170...81,375,809
Ensembl chr 9:81,347,173...81,375,806

G

plasmanylethanolamine desaturase 1

increases expression

ISO

Tamoxifen results in increased expression of PEDS1 mRNA

NCBI chr 3:176,769,111...176,788,278

G

proline, glutamate and leucine rich protein 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to PELP1 protein]

NCBI chr10:55,593,444...55,610,478
Ensembl chr10:55,593,447...55,610,758

G

phosphatidylethanolamine N-methyltransferase

multiple interactions
decreases expression

ISO

Tamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression of PEMT mRNA]
Tamoxifen results in decreased expression of PEMT mRNA

PMID:20150657 PMID:25123088

NCBI chr10:45,275,434...45,349,651
Ensembl chr10:45,275,412...45,420,037

G

proenkephalin

affects expression

ISO

Tamoxifen affects the expression of PENK mRNA

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705

G

peptidase D

affects expression

ISO

Tamoxifen affects the expression of PEPD mRNA

NCBI chr 1:96,673,624...96,818,197
Ensembl chr 1:96,673,607...96,818,190

G

period circadian regulator 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of PER1 mRNA
Tamoxifen results in increased expression of PER1 mRNA

PMID:20937368 PMID:25123088

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

peroxisomal biogenesis factor 1

affects expression

ISO

Tamoxifen affects the expression of PEX1 mRNA

NCBI chr 4:31,474,670...31,513,621
Ensembl chr 4:31,470,845...31,513,811

G

peroxisomal biogenesis factor 11 alpha

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of PEX11A mRNA

NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645

G

prefoldin subunit 5

affects expression

ISO

Tamoxifen affects the expression of PFDN5 mRNA

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of PFKFB3 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA

PMID:19059307 PMID:20937368

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

profilin 2

affects expression

ISO

Tamoxifen affects the expression of PFN2 mRNA

NCBI chr 2:144,217,100...144,222,936
Ensembl chr 2:144,205,636...144,222,936

G

post-GPI attachment to proteins 2

affects expression

ISO

Tamoxifen affects the expression of PGAP2 mRNA

NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:166,003,523...166,030,088

G

progastricsin

decreases expression

ISO

Tamoxifen results in decreased expression of PGC mRNA

NCBI chr 9:20,755,002...20,763,220
Ensembl chr 9:20,755,002...20,763,220

G

phosphogluconate dehydrogenase

affects expression

ISO

Tamoxifen affects the expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

placental growth factor

affects expression

ISO

Tamoxifen affects the expression of PGF mRNA

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747

G

protein geranylgeranyltransferase type I subunit beta

increases expression

ISO

Tamoxifen results in increased expression of PGGT1B mRNA

NCBI chr18:41,138,536...41,182,145
Ensembl chr18:41,139,965...41,182,139

G

phosphoglycerate kinase 1

increases expression

EXP
ISO

Tamoxifen results in increased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

phosphoglucomutase 1

increases expression

ISO

Tamoxifen results in increased expression of PGM1 mRNA

NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:119,710,737...119,770,159

G

pyroglutamyl-peptidase I

affects expression

ISO

Tamoxifen affects the expression of PGPEP1 mRNA

PMID:17555576 PMID:20937368

NCBI chr16:18,804,408...18,817,466
Ensembl chr16:18,805,009...18,817,462

G

progesterone receptor

multiple interactions
increases expression
decreases expression
increases response to substance
affects response to substance

ISO
EXP

[bisphenol A co-treated with Tamoxifen] results in increased expression of PGR mRNA; [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein; [Tamoxifen co-treated with glyceollin] results in decreased expression of PGR mRNA; BRCA1 protein affects the reaction [Tamoxifen results in decreased expression of PGR mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; Tamoxifen promotes the reaction [ESR1 protein binds to PGR promoter]; Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]; U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of PGR mRNA]]; U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]]
Tamoxifen results in increased expression of PGR mRNA; Tamoxifen results in increased expression of PGR protein
[Estradiol co-treated with Tamoxifen] results in increased expression of PGR protein; Tamoxifen inhibits the reaction [Estradiol results in increased expression of PGR mRNA]
Tamoxifen analog results in decreased expression of PGR protein; Tamoxifen results in decreased expression of PGR mRNA; Tamoxifen results in decreased expression of PGR protein
PGR protein results in increased susceptibility to Tamoxifen
PGR protein affects the susceptibility to Tamoxifen

PMID:2079700 PMID:2127240 PMID:9208491 PMID:11748029 PMID:12834913 More...

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

progesterone receptor membrane component 1

affects expression

ISO

Tamoxifen affects the expression of PGRMC1 mRNA

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

progesterone receptor membrane component 2

affects expression

ISO

Tamoxifen affects the expression of PGRMC2 mRNA

NCBI chr 2:125,996,190...126,012,090
Ensembl chr 2:125,996,193...126,012,090

G

phosphatidylglycerophosphate synthase 1

affects expression

ISO

Tamoxifen affects the expression of PGS1 mRNA

NCBI chr10:103,713,306...103,748,924
Ensembl chr10:103,713,316...103,749,233

G

prohibitin 1

affects expression

ISO

Tamoxifen affects the expression of PHB1 mRNA

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233

G

prohibitin 2

multiple interactions
affects expression

ISO

BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]]; Tamoxifen promotes the reaction [ESR1 protein binds to PHB2 protein]
Tamoxifen affects the expression of PHB2 mRNA

PMID:17555576 PMID:18997820

NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:159,203,926...159,209,231

G

polyhomeotic homolog 2

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA
Tamoxifen affects the expression of PHC2 mRNA

PMID:17555576 PMID:19059307

NCBI chr 5:146,285,000...146,383,664
Ensembl chr 5:146,285,008...146,383,663

G

PHD finger protein 11

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA

NCBI chr15:37,568,090...37,592,490
Ensembl chr15:37,568,090...37,591,016

G

PHD finger protein 21B

increases expression

ISO

Tamoxifen results in increased expression of PHF21B mRNA

NCBI chr 7:117,793,643...117,864,141
Ensembl chr 7:117,794,046...117,864,141

G

PHD finger protein 23

affects expression

ISO

Tamoxifen affects the expression of PHF23 mRNA

NCBI chr10:55,217,351...55,221,471
Ensembl chr10:55,217,351...55,221,471

G

PHD finger protein 5A

affects expression

ISO

Tamoxifen affects the expression of PHF5A mRNA

NCBI chr 7:115,258,609...115,265,174
Ensembl chr 7:115,258,609...115,265,174

G

PHD finger protein 7

affects expression

ISO

Tamoxifen affects the expression of PHF7 mRNA

NCBI chr16:6,439,968...6,452,671
Ensembl chr16:6,439,970...6,452,671

G

phosphoglycerate dehydrogenase

affects expression

ISO

Tamoxifen affects the expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

phosphorylase kinase catalytic subunit gamma 2

affects expression

ISO

Tamoxifen affects the expression of PHKG2 mRNA

NCBI chr 1:191,614,738...191,627,615
Ensembl chr 1:191,614,865...191,627,616

G

pleckstrin homology-like domain, family A, member 3

increases expression

ISO

Tamoxifen results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

pleckstrin homology-like domain, family B, member 1

increases expression

ISO

Tamoxifen results in increased expression of PHLDB1 mRNA

NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:53,900,338...53,949,518

G

phosphatase, orphan 2

affects expression

ISO

Tamoxifen affects the expression of PHOSPHO2 mRNA

NCBI chr 3:74,962,649...74,969,810
Ensembl chr 3:74,962,361...74,970,892

G

phosphohistidine phosphatase 1

affects expression

ISO

Tamoxifen affects the expression of PHPT1 mRNA

NCBI chr 3:28,791,062...28,792,905

G

protein interacting with PRKCA 1

affects expression

ISO

Tamoxifen affects the expression of PICK1 mRNA

NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:112,677,322...112,697,257

G

phosphatidylinositol glycan anchor biosynthesis, class A

affects expression

ISO

Tamoxifen affects the expression of PIGA mRNA

NCBI chr X:33,672,832...33,687,747
Ensembl chr X:33,674,923...33,687,636

G

phosphatidylinositol glycan anchor biosynthesis, class C

affects expression

ISO

Tamoxifen affects the expression of PIGC mRNA

NCBI chr13:76,876,894...76,879,420
Ensembl chr13:76,872,922...76,880,224

G

phosphatidylinositol glycan anchor biosynthesis, class N

increases expression

ISO

Tamoxifen results in increased expression of PIGN mRNA

NCBI chr13:22,173,670...22,321,344
Ensembl chr13:22,176,576...22,321,379

G

phosphatidylinositol glycan anchor biosynthesis, class Y

affects expression

ISO

Tamoxifen affects the expression of PIGY mRNA

NCBI chr 8:28,965,634...28,967,876
Ensembl chr 8:28,965,617...28,968,508

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

affects expression

ISO

Tamoxifen affects the expression of PIK3C2A mRNA

NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

affects response to substance

ISO

PIK3CA gene mutant form affects the susceptibility to Tamoxifen

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

ISO

Tamoxifen results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

ISO

Tamoxifen results in increased expression of PIM1 mRNA

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

multiple interactions
affects expression
decreases response to substance

ISO

Tamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein]
Tamoxifen affects the expression of PIN1 mRNA
PIN1 protein results in decreased susceptibility to Tamoxifen

PMID:17555576 PMID:19671742 PMID:20479004

NCBI chr 8:27,465,538...27,477,016

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 4

affects expression

ISO

Tamoxifen affects the expression of PIN4 mRNA

NCBI chr X:71,272,034...71,278,676
Ensembl chr X:71,272,043...71,289,187

G

PTEN induced kinase 1

affects expression

ISO

Tamoxifen affects the expression of PINK1 mRNA

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

affects expression

ISO

Tamoxifen affects the expression of PIP5K1C mRNA

NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716

G

phosphatidylinositol transfer protein, cytoplasmic 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA

NCBI chr10:92,663,260...92,928,616
Ensembl chr10:92,663,260...92,928,344

G

paired-like homeodomain 3

decreases expression

ISO

Tamoxifen results in decreased expression of PITX3 mRNA

NCBI chr 1:254,942,550...254,955,325
Ensembl chr 1:254,942,608...254,955,336

G

polycystin 1, transient receptor potential channel interacting

affects expression

ISO

Tamoxifen affects the expression of PKD1 mRNA

NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681

G

PKHD1 ciliary IPT domain containing fibrocystin/polyductin

affects expression

ISO

Tamoxifen affects the expression of PKHD1 mRNA

NCBI chr 9:30,040,466...30,533,834
Ensembl chr 9:30,046,038...30,533,935

G

cAMP-dependent protein kinase inhibitor beta

affects expression
multiple interactions

ISO
EXP

Tamoxifen affects the expression of PKIB mRNA
[bexarotene co-treated with Tamoxifen] results in increased expression of PKIB mRNA

PMID:17555576 PMID:17630414

NCBI chr20:37,511,564...37,608,607
Ensembl chr20:37,512,822...37,608,401

G

pyruvate kinase L/R

affects expression
decreases expression

ISO
EXP

Tamoxifen affects the expression of PKLR mRNA
Tamoxifen results in decreased expression of PKLR mRNA

PMID:17555576 PMID:19224547 PMID:20937368 PMID:25123088

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

protein kinase N2

affects expression

ISO

Tamoxifen affects the expression of PKN2 mRNA

NCBI chr 2:234,454,001...234,559,369
Ensembl chr 2:234,454,001...234,594,649

G

protein kinase N3

affects expression

ISO

Tamoxifen affects the expression of PKN3 mRNA

NCBI chr 3:33,747,610...33,761,405
Ensembl chr 3:33,747,867...33,761,405

G

phospholipase A2, group X

affects expression

ISO

Tamoxifen affects the expression of PLA2G10 mRNA

NCBI chr10:2,104,927...2,117,998
Ensembl chr10:2,104,927...2,116,172

G

phospholipase A2, group XIIB

affects expression

ISO

Tamoxifen affects the expression of PLA2G12B mRNA

NCBI chr20:27,910,620...27,931,734
Ensembl chr20:27,913,259...27,932,148

G

phospholipase A2, group XV

affects expression

ISO

Tamoxifen affects the expression of PLA2G15 mRNA

NCBI chr19:50,960,568...50,977,948
Ensembl chr19:50,960,598...50,977,946

G

phospholipase A2 group IIA

affects expression

ISO

Tamoxifen affects the expression of PLA2G2A mRNA

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

phospholipase A2, group IID

affects expression

ISO

Tamoxifen affects the expression of PLA2G2D mRNA

NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:156,297,777...156,305,812

G

phospholipase A2 group 4A

decreases response to substance

ISO

PLA2G4A mRNA results in decreased susceptibility to Tamoxifen

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

phospholipase A2 group VII

decreases expression
affects expression

ISO

Tamoxifen results in decreased expression of PLA2G7 mRNA
Tamoxifen affects the expression of PLA2G7 mRNA

PMID:17555576 PMID:19429434 PMID:20937368

NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747

G

placenta associated 8

affects expression

ISO

Tamoxifen affects the expression of PLAC8 mRNA

NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572

G

PLAG1 like zinc finger 1

affects expression

ISO

Tamoxifen affects the expression of PLAGL1 mRNA

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:9,330,204...9,337,394

G

plasminogen activator, urokinase

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plectin

affects expression

ISO

Tamoxifen affects the expression of PLEC mRNA

NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089

G

pleckstrin 2

affects expression

ISO

Tamoxifen affects the expression of PLEK2 mRNA

NCBI chr 6:103,434,156...103,452,457
Ensembl chr 6:103,434,156...103,452,371

G

pleckstrin homology domain containing A2

affects expression

ISO

Tamoxifen affects the expression of PLEKHA2 mRNA

NCBI chr16:73,641,338...73,704,068
Ensembl chr16:73,641,344...73,703,087

G

pleckstrin homology and RhoGEF domain containing G6

decreases expression

ISO

Tamoxifen results in decreased expression of PLEKHG6 mRNA

NCBI chr 4:159,849,987...159,885,730
Ensembl chr 4:159,849,364...159,868,122

G

pleckstrin homology and RUN domain containing M2

increases expression

ISO

Tamoxifen results in increased expression of PLEKHM2 mRNA

NCBI chr 5:159,222,620...159,261,666
Ensembl chr 5:159,223,300...159,261,642

G

plasminogen

increases expression

ISO

Tamoxifen results in increased expression of PLG protein

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320

G

perilipin 4

affects expression

ISO

Tamoxifen affects the expression of PLIN4 mRNA

NCBI chr 9:1,016,334...1,025,249
Ensembl chr 9:1,016,302...1,025,368

G

perilipin 5

affects expression

ISO

Tamoxifen affects the expression of PLIN5 mRNA

NCBI chr 9:1,026,910...1,033,352
Ensembl chr 9:1,026,307...1,033,284

G

polo-like kinase 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [Estradiol results in increased expression of PLK1 protein]

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

polo-like kinase 2

affects expression

ISO

Tamoxifen affects the expression of PLK2 mRNA

PMID:17555576 PMID:20937368

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

polo-like kinase 3

affects expression

ISO

Tamoxifen affects the expression of PLK3 mRNA

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

plasmolipin

increases expression

ISO

Tamoxifen results in increased expression of PLLP mRNA

NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,321,080...10,342,226

G

phospholamban

decreases expression

ISO

Tamoxifen results in decreased expression of PLN mRNA

NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

increases expression

ISO

Tamoxifen results in increased expression of PLOD2 mRNA

NCBI chr 8:101,964,318...102,047,022
Ensembl chr 8:101,964,318...102,047,022

G

phospholipid phosphatase 3

affects expression

ISO

Tamoxifen affects the expression of PLPP3 mRNA

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667

G

pleiotropic regulator 1

affects expression

ISO

Tamoxifen affects the expression of PLRG1 mRNA

NCBI chr 2:170,706,188...170,722,519
Ensembl chr 2:170,706,173...170,722,573

G

phospholipid scramblase 1

affects expression

ISO

Tamoxifen affects the expression of PLSCR1 mRNA

PMID:14699072 PMID:20937368

NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:101,664,056...101,684,614

G

phospholipid transfer protein

affects expression

ISO

Tamoxifen affects the expression of PLTP mRNA

NCBI chr 3:173,994,162...174,011,982
Ensembl chr 3:173,994,162...174,012,505

G

polyamine modulated factor 1 binding protein 1

affects expression

ISO

Tamoxifen affects the expression of PMFBP1 mRNA

NCBI chr19:54,367,562...54,417,405
Ensembl chr19:54,367,433...54,417,405

G

phosphomannomutase 2

affects expression

ISO

Tamoxifen affects the expression of PMM2 mRNA

NCBI chr10:7,468,371...7,489,574
Ensembl chr10:7,468,372...7,489,554

G

peptidase, mitochondrial processing subunit beta

affects expression

ISO

Tamoxifen affects the expression of PMPCB mRNA

NCBI chr 4:14,189,807...14,202,584
Ensembl chr 4:14,165,844...14,202,615

G

PNKD metallo-beta-lactamase domain containing

affects expression

ISO

Tamoxifen affects the expression of PNKD mRNA

NCBI chr 9:83,317,757...83,386,263
Ensembl chr 9:83,317,738...83,386,262

G

purine nucleoside phosphorylase

affects expression

ISO

Tamoxifen affects the expression of PNP mRNA

NCBI chr15:26,644,147...26,651,808
Ensembl chr15:26,643,858...26,678,162

G

patatin-like phospholipase domain containing 2

affects expression

ISO

Tamoxifen affects the expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

patatin-like phospholipase domain containing 3

affects expression

ISO

Tamoxifen affects the expression of PNPLA3 mRNA

NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:117,173,516...117,194,594

G

polyribonucleotide nucleotidyltransferase 1

affects expression

ISO

Tamoxifen affects the expression of PNPT1 mRNA

NCBI chr14:107,078,486...107,109,628
Ensembl chr14:107,078,469...107,109,628

G

podocalyxin-like

affects expression

ISO

Tamoxifen affects the expression of PODXL mRNA

NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:61,102,419...61,149,789

G

protein O-glucosyltransferase 2

affects expression

ISO

Tamoxifen affects the expression of POGLUT2 mRNA

NCBI chr 9:53,748,484...53,801,453
Ensembl chr 9:53,740,998...53,760,588

G

DNA polymerase beta

decreases expression

EXP

Tamoxifen results in decreased expression of POLB protein

NCBI chr16:76,081,903...76,105,174
Ensembl chr16:76,081,864...76,108,180

G

DNA polymerase delta 2, accessory subunit

affects expression

ISO

Tamoxifen affects the expression of POLD2 mRNA

NCBI chr14:84,962,933...84,969,148
Ensembl chr14:84,962,022...84,967,874

G

DNA polymerase delta 4, accessory subunit

affects expression

ISO

Tamoxifen affects the expression of POLD4 mRNA

NCBI chr 1:210,956,110...210,957,863
Ensembl chr 1:210,956,099...210,957,860

G

DNA polymerase delta interacting protein 2

increases expression

ISO

Tamoxifen results in increased expression of POLDIP2 mRNA

NCBI chr10:63,905,287...63,915,655
Ensembl chr10:63,904,691...63,915,655

G

DNA polymerase lambda

affects expression

ISO

Tamoxifen affects the expression of POLL mRNA

NCBI chr 1:254,349,229...254,357,689
Ensembl chr 1:254,349,231...254,358,020

G

RNA polymerase I and III subunit D

affects expression

ISO

Tamoxifen affects the expression of POLR1D mRNA

NCBI chr12:13,084,505...13,118,069
Ensembl chr12:13,084,512...13,095,627

G

RNA polymerase II subunit J

increases expression

ISO

Tamoxifen results in increased expression of POLR2J mRNA

NCBI chr12:26,179,649...26,185,201
Ensembl chr12:26,179,649...26,185,201

G

RNA polymerase III subunit F

affects expression

ISO

Tamoxifen affects the expression of POLR3F mRNA

NCBI chr 3:152,361,798...152,378,169
Ensembl chr 3:152,361,798...152,378,168

G

RNA polymerase III subunit G

affects expression

ISO

Tamoxifen affects the expression of POLR3G mRNA

NCBI chr 2:13,680,893...13,721,802
Ensembl chr 2:13,680,895...13,721,802

G

protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)

affects expression

ISO

Tamoxifen affects the expression of POMGNT1 mRNA

NCBI chr 5:134,870,971...134,880,864
Ensembl chr 5:134,870,975...134,880,863

G

protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)

affects expression

ISO

Tamoxifen affects the expression of POMGNT2 mRNA

NCBI chr 8:130,522,607...130,538,273
Ensembl chr 8:130,521,459...130,571,943

G

paraoxonase 1

decreases expression

ISO

Tamoxifen results in decreased expression of PON1 mRNA

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

POP4 homolog, ribonuclease P/MRP subunit

affects expression

ISO

Tamoxifen affects the expression of POP4 mRNA

NCBI chr 1:100,096,722...100,105,056
Ensembl chr 1:100,096,723...100,105,104

G

popeye domain cAMP effector 2

affects expression

ISO

Tamoxifen affects the expression of POPDC2 mRNA

NCBI chr11:75,850,068...75,897,094
Ensembl chr11:75,880,274...75,896,269

G

cytochrome p450 oxidoreductase

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of POR mRNA
Tamoxifen results in increased expression of POR mRNA

PMID:15089088 PMID:20937368

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

periostin

affects expression

ISO

Tamoxifen affects the expression of POSTN mRNA

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300

G

protection of telomeres 1

affects expression

ISO

Tamoxifen affects the expression of POT1 mRNA

NCBI chr 4:55,170,821...55,228,588
Ensembl chr 4:55,170,821...55,228,543

G

POU class 5 homeobox 1

decreases expression

ISO

Tamoxifen results in decreased expression of POU5F1 protein

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

POU class 6 homeobox 1

decreases expression

ISO

Tamoxifen results in decreased expression of POU6F1 mRNA

NCBI chr 7:133,556,506...133,580,004
Ensembl chr 7:133,558,928...133,579,671

G

peter pan homolog

affects expression

ISO

Tamoxifen affects the expression of PPAN mRNA

NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:27,700,152...27,704,128

G

peroxisome proliferator activated receptor alpha

decreases expression

ISO

Tamoxifen results in decreased expression of PPARA protein

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

increases expression
decreases expression
multiple interactions

ISO

Tamoxifen results in increased expression of PPARG mRNA
Tamoxifen results in decreased expression of PPARG protein
PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; PPARG mRNA promotes the reaction [Tamoxifen results in decreased expression of CD36 mRNA]; PPARG mRNA promotes the reaction [Tamoxifen results in decreased expression of CD36 protein]; Tamoxifen binds to and results in decreased activity of PPARG protein
[Tamoxifen co-treated with Oleic Acid] results in increased expression of PPARG mRNA; Tamoxifen inhibits the reaction [PPARG protein binds to CD36 promoter]; Tamoxifen inhibits the reaction [PPARG protein results in increased expression of CD36 mRNA]; Tamoxifen results in decreased expression of and results in increased phosphorylation of PPARG protein

PMID:25123088 PMID:27358406 PMID:33049310 PMID:38191086

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression
increases expression

ISO

[Tamoxifen co-treated with bisphenol A] results in increased expression of PPARGC1A mRNA; Tamoxifen inhibits the reaction [PPARGC1A protein binds to ESRRG protein]; Tamoxifen inhibits the reaction [Quercetin results in increased expression of PPARGC1A mRNA]
Tamoxifen results in decreased expression of PPARGC1A mRNA
Tamoxifen results in increased expression of PPARGC1A mRNA

PMID:16889744 PMID:27089845 PMID:30467747 PMID:32530119

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

PPARG coactivator 1 beta

affects expression
decreases expression
multiple interactions

ISO

Tamoxifen affects the expression of PPARGC1B mRNA
Tamoxifen results in decreased expression of PPARGC1B mRNA
[bisphenol A co-treated with Tamoxifen] results in increased expression of PPARGC1B mRNA; bisphenol A affects the reaction [Tamoxifen affects the expression of PPARGC1B mRNA]; Tamoxifen inhibits the reaction [Quercetin results in increased expression of PPARGC1B mRNA]

PMID:30467747 PMID:32530119

NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466

G

phosphoribosyl pyrophosphate amidotransferase

affects expression

ISO

Tamoxifen affects the expression of PPAT mRNA

NCBI chr14:31,570,010...31,604,410
Ensembl chr14:31,551,388...31,604,405

G

phosphopantothenoylcysteine synthetase

affects expression

ISO

Tamoxifen affects the expression of PPCS mRNA

NCBI chr 5:138,308,394...138,312,047
Ensembl chr 5:138,308,397...138,312,012

G

PTPRF interacting protein alpha 3

increases expression

ISO

Tamoxifen results in increased expression of PPFIA3 mRNA

NCBI chr 1:104,953,598...104,982,373
Ensembl chr 1:104,953,598...104,982,278

G

periphilin 1

affects expression

ISO

Tamoxifen affects the expression of PPHLN1 mRNA

NCBI chr 7:126,418,042...126,509,430
Ensembl chr 7:126,417,555...126,509,430

G

peptidylprolyl isomerase A

decreases expression
multiple interactions

ISO

Tamoxifen results in decreased expression of PPIA protein
[Tretinoin co-treated with Tamoxifen] results in decreased expression of PPIA protein

NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115

G

peptidylprolyl isomerase H

affects expression

ISO

Tamoxifen affects the expression of PPIH mRNA

NCBI chr 5:138,191,624...138,209,625
Ensembl chr 5:138,191,624...138,209,580

G

peptidylprolyl isomerase like 2

affects expression

ISO

Tamoxifen affects the expression of PPIL2 mRNA

NCBI chr11:97,401,944...97,424,581
Ensembl chr11:97,401,963...97,430,769

G

periplakin

decreases expression

ISO

Tamoxifen results in decreased expression of PPL mRNA

NCBI chr10:10,957,388...11,003,035
Ensembl chr10:10,957,341...11,003,658

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

affects expression

ISO

Tamoxifen affects the expression of PPM1A mRNA

NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

affects expression

ISO

Tamoxifen affects the expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756

G

protein phosphatase, Mg2+/Mn2+ dependent, 1G

affects expression

ISO

Tamoxifen affects the expression of PPM1G mRNA

NCBI chr 6:30,873,531...30,893,735
Ensembl chr 6:30,873,481...30,893,732

G

protein phosphatase 1, regulatory subunit 10

affects expression

ISO

Tamoxifen affects the expression of PPP1R10 mRNA

NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,827,802...2,842,418

G

protein phosphatase 1, regulatory subunit 12B

affects expression

ISO

Tamoxifen affects the expression of PPP1R12B mRNA

NCBI chr13:48,751,256...48,948,933
Ensembl chr13:48,751,477...48,948,922

G

protein phosphatase 1, regulatory subunit 13B

affects expression

ISO

Tamoxifen affects the expression of PPP1R13B mRNA

NCBI chr 6:136,711,834...136,785,068
Ensembl chr 6:136,711,834...136,785,113

G

protein phosphatase 1, regulatory subunit 15B

affects expression

ISO

Tamoxifen affects the expression of PPP1R15B mRNA

NCBI chr13:47,130,000...47,137,805
Ensembl chr13:47,129,967...47,137,798

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

affects expression

ISO

Tamoxifen affects the expression of PPP1R2 mRNA

NCBI chr11:82,977,634...82,999,426
Ensembl chr11:82,977,515...83,001,083

G

protein phosphatase 1, regulatory subunit 3C

affects expression

ISO

Tamoxifen affects the expression of PPP1R3C mRNA

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835

G

protein phosphatase 1, regulatory subunit 8

affects expression

ISO

Tamoxifen affects the expression of PPP1R8 mRNA

NCBI chr 5:150,315,607...150,332,726
Ensembl chr 5:150,315,494...150,332,726

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

ISO

Tamoxifen results in decreased expression of PPP2CA mRNA

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 2 regulatory subunit B', epsilon

affects expression

ISO

Tamoxifen affects the expression of PPP2R5E mRNA

NCBI chr 6:99,904,569...100,053,672
Ensembl chr 6:99,904,569...100,053,573

G

protein phosphatase 3, regulatory subunit B, alpha

affects expression

ISO

Tamoxifen affects the expression of PPP3R1 mRNA

NCBI chr14:95,758,333...95,808,015

G

protein phosphatase 4, regulatory subunit 1

affects expression

ISO

Tamoxifen affects the expression of PPP4R1 mRNA

NCBI chr 9:112,836,950...112,897,490
Ensembl chr 9:112,838,812...112,897,557

G

protein phosphatase 5, catalytic subunit

decreases expression

ISO

Tamoxifen results in decreased expression of PPP5C mRNA

NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950

G

palmitoyl-protein thioesterase 1

affects expression

ISO

Tamoxifen affects the expression of PPT1 mRNA

NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200

G

protein phosphatase targeting COQ7

affects expression

ISO

Tamoxifen affects the expression of PPTC7 mRNA

NCBI chr12:39,910,728...39,949,101
Ensembl chr12:39,910,742...39,949,101

G

polyglutamine binding protein 1

affects expression

ISO

Tamoxifen affects the expression of PQBP1 mRNA

NCBI chr X:17,275,445...17,280,018
Ensembl chr X:17,275,759...17,280,016

G

PRAME like, X-linked 1

multiple interactions

ISO

Tamoxifen inhibits the reaction [ESR1 protein binds to PRAME protein]

NCBI chr X:102,862,457...102,867,725
Ensembl chr X:102,861,881...102,870,708

G

proline-rich acidic protein 1

affects expression

ISO

Tamoxifen affects the expression of PRAP1 mRNA

NCBI chr 1:204,312,723...204,316,519
Ensembl chr 1:204,312,723...204,316,517

G

peroxiredoxin 3

affects expression

ISO

Tamoxifen affects the expression of PRDX3 mRNA

PMID:14699072 PMID:17555576

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

PRELI domain containing 2

decreases expression

ISO

Tamoxifen results in decreased expression of PRELID2 mRNA

NCBI chr18:34,120,989...34,212,699
Ensembl chr18:34,125,373...34,212,167

G

prolyl endopeptidase

affects expression

ISO

Tamoxifen affects the expression of PREP mRNA

NCBI chr20:50,138,588...50,235,549
Ensembl chr20:50,131,819...50,252,697

G

perforin 1

decreases expression
increases expression

ISO

Tamoxifen results in decreased expression of PRF1 mRNA; Tamoxifen results in decreased expression of PRF1 protein
[Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA

NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124

G

prickle planar cell polarity protein 3

affects expression

ISO

Tamoxifen affects the expression of PRICKLE3 mRNA

NCBI chr X:17,509,551...17,520,157
Ensembl chr X:17,509,554...17,520,122

G

protein kinase cAMP-activated catalytic subunit beta

affects expression

ISO

Tamoxifen affects the expression of PRKACB mRNA

PMID:17555576 PMID:20937368

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase cAMP-dependent type I regulatory subunit alpha

affects expression

ISO

Tamoxifen affects the expression of PRKAR1A mRNA

NCBI chr10:95,120,537...95,139,028
Ensembl chr10:95,120,487...95,139,025

G

protein kinase cAMP-dependent type I regulatory subunit beta

affects expression

ISO

Tamoxifen affects the expression of PRKAR1B mRNA

NCBI chr12:20,606,066...20,738,766
Ensembl chr12:20,618,757...20,738,766

G

protein kinase C, alpha

affects expression
decreases phosphorylation

ISO

Tamoxifen affects the expression of PRKCA mRNA
Tamoxifen results in decreased phosphorylation of PRKCA protein

PMID:17555576 PMID:19393235

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, delta

decreases phosphorylation

ISO

Tamoxifen results in decreased phosphorylation of PRKCD protein

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase C, epsilon

affects localization

ISO

Tamoxifen affects the localization of PRKCE protein

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, zeta

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

protein kinase D3

affects expression

ISO

Tamoxifen affects the expression of PRKD3 mRNA

NCBI chr 6:21,784,665...21,860,600
Ensembl chr 6:21,784,673...21,860,600

G

protein kinase cGMP-dependent 1

affects expression

ISO

Tamoxifen affects the expression of PRKG1 mRNA

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005

G

prolactin

affects expression
multiple interactions
increases expression
decreases secretion

ISO
EXP

Tamoxifen affects the expression of PRL mRNA
Tamoxifen inhibits the reaction [Estradiol results in increased expression of PRL mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of PRL protein]
Tamoxifen results in increased expression of PRL mRNA
Tamoxifen results in decreased secretion of PRL protein

PMID:7306549 PMID:15470002 PMID:15950373 PMID:17555576

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prolactin receptor

multiple interactions
decreases expression

EXP
ISO

[bexarotene co-treated with Tamoxifen] results in decreased expression of PRLR mRNA
Tamoxifen results in decreased expression of PRLR mRNA

PMID:17630414 PMID:25123088

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

protamine 3

affects expression

ISO

Tamoxifen affects the expression of PRM3 mRNA

NCBI chr10:5,384,394...5,384,908

G

protein arginine methyltransferase 7

affects expression

ISO

Tamoxifen affects the expression of PRMT7 mRNA

NCBI chr19:51,020,596...51,071,401
Ensembl chr19:51,020,512...51,072,424

G

protein C, inactivator of coagulation factors Va and VIIIa

decreases expression

ISO

Tamoxifen results in decreased expression of PROC protein

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

prominin 1

multiple interactions
decreases expression

EXP
ISO

[bexarotene co-treated with Tamoxifen] results in decreased expression of PROM1 mRNA
Tamoxifen results in decreased expression of PROM1 mRNA

PMID:17630414 PMID:25123088

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

protein S

decreases expression
affects expression

ISO

Tamoxifen results in decreased expression of PROS1 protein
Tamoxifen affects the expression of PROS1 protein

PMID:12492585 PMID:15850603

NCBI chr11:13,676,310...13,757,858
Ensembl chr11:13,676,769...13,757,852

G

pre-mRNA processing factor 31

affects expression

ISO

Tamoxifen affects the expression of PRPF31 mRNA

NCBI chr 1:74,491,247...74,502,922
Ensembl chr 1:74,491,247...74,502,922

G

pre-mRNA processing factor 38A

affects expression

ISO

Tamoxifen affects the expression of PRPF38A mRNA

NCBI chr 5:128,541,166...128,552,865
Ensembl chr 5:128,541,166...128,552,865

G

pre-mRNA processing factor 40 homolog A

affects expression

ISO

Tamoxifen affects the expression of PRPF40A mRNA

NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363

G

pre-mRNA processing factor 4B

increases expression
affects expression

ISO

Tamoxifen results in increased expression of PRP4K mRNA
Tamoxifen affects the expression of PRPF4B mRNA

PMID:15590111 PMID:17555576

NCBI chr17:30,190,721...30,230,153
Ensembl chr17:30,193,907...30,225,420

G

pre-mRNA processing factor 8

affects expression

ISO

Tamoxifen affects the expression of PRPF8 mRNA

NCBI chr10:60,829,778...60,852,887
Ensembl chr10:60,829,778...60,852,887

G

phosphoribosyl pyrophosphate synthetase 1

affects expression

ISO

Tamoxifen affects the expression of PRPS1 mRNA

NCBI chr X:108,920,663...108,942,713
Ensembl chr X:108,920,651...108,942,711

G

phosphoribosyl pyrophosphate synthetase 1-like 1

decreases expression

ISO

Tamoxifen results in decreased expression of PRPS1L1 mRNA

NCBI chr 6:57,412,331...57,414,021
Ensembl chr 6:57,411,794...57,415,712

G

proline rich 15

multiple interactions

EXP

[bexarotene co-treated with Tamoxifen] results in increased expression of PRR15 mRNA

NCBI chr 4:84,762,357...84,765,403
Ensembl chr 4:84,761,523...84,768,442

G

proline rich 15-like

increases expression

ISO

Tamoxifen results in increased expression of PRR15L mRNA

NCBI chr10:82,412,934...82,418,897
Ensembl chr10:82,402,733...82,419,558

G

proline rich 18

increases expression

ISO

Tamoxifen results in increased expression of PRR18 mRNA

NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:54,947,351...54,959,997

G

paired related homeobox 1

increases expression

ISO

Tamoxifen results in increased expression of PRRX1 mRNA

NCBI chr13:78,136,783...78,205,379
Ensembl chr13:78,136,783...78,204,058

G

serine protease 29

affects expression

ISO

Tamoxifen affects the expression of PRSS29 mRNA

NCBI chr10:14,841,808...14,845,531
Ensembl chr10:14,841,905...14,845,332

G

serine protease 8

decreases expression

ISO

Tamoxifen results in decreased expression of PRSS8 mRNA

NCBI chr 1:191,966,701...191,971,271
Ensembl chr 1:191,966,701...191,971,193

G

proteinase 3

increases expression

ISO

Tamoxifen results in increased expression of PRTN3 mRNA

NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:10,472,755...10,482,474

G

prosaposin

affects expression

ISO

Tamoxifen affects the expression of PSAP mRNA

NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,757,181...28,783,421

G

pleckstrin and Sec7 domain containing 3

affects expression

ISO

Tamoxifen affects the expression of PSD3 mRNA

NCBI chr16:26,238,595...26,802,535
Ensembl chr16:26,340,028...26,802,535

G

presenilin enhancer gamma secretase subunit

affects expression

ISO

Tamoxifen affects the expression of PSENEN mRNA

NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:94,942,225...94,943,752

G

protein serine kinase H1

decreases expression

ISO

Tamoxifen results in decreased expression of PSKH1 mRNA

NCBI chr19:50,704,780...50,736,890
Ensembl chr19:50,704,781...50,736,892

G

proteasome 20S subunit alpha 1

increases expression
affects expression
multiple interactions

ISO

Tamoxifen results in increased expression of PSMA1 protein
Tamoxifen affects the expression of PSMA1 mRNA
[Tretinoin co-treated with Tamoxifen] results in decreased expression of PSMA1 protein

PMID:17098229 PMID:17555576

NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:177,875,353...177,887,949

G

proteasome 20S subunit alpha 4

affects expression

ISO

Tamoxifen affects the expression of PSMA4 mRNA

NCBI chr 8:64,236,520...64,243,980
Ensembl chr 8:64,236,783...64,243,979

G

proteasome 20S subunit alpha 5

increases expression

ISO
EXP

Tamoxifen results in increased expression of PSMA5 mRNA

NCBI chr 2:198,584,502...198,607,867
Ensembl chr 2:198,584,505...198,607,867

G

proteasome 20S subunit alpha 6

affects expression

ISO

Tamoxifen affects the expression of PSMA6 mRNA

NCBI chr 6:78,500,676...78,531,693
Ensembl chr 6:78,500,736...78,531,717

G

proteasome 20S subunit beta 2

affects expression

ISO

Tamoxifen affects the expression of PSMB2 mRNA

NCBI chr 5:144,255,058...144,287,200
Ensembl chr 5:144,255,026...144,287,608

G

proteasome 20S subunit beta 3

affects expression

ISO

Tamoxifen affects the expression of PSMB3 mRNA

NCBI chr10:83,193,787...83,200,883
Ensembl chr10:83,193,787...83,200,883

G

proteasome 20S subunit beta 4

affects expression

ISO

Tamoxifen affects the expression of PSMB4 mRNA

NCBI chr 2:185,131,787...185,134,561
Ensembl chr 2:185,131,786...185,135,287

G

proteasome 20S subunit beta 5

affects expression
increases expression

ISO
EXP

Tamoxifen affects the expression of PSMB5 mRNA
Tamoxifen results in increased expression of PSMB5 mRNA

PMID:17555576 PMID:19400957

NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379

G

proteasome 20S subunit beta 9

affects expression

ISO

Tamoxifen affects the expression of PSMB9 mRNA

NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421

G

proteasome 26S subunit, ATPase 2

affects expression

ISO

Tamoxifen affects the expression of PSMC2 mRNA

NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:14,148,090...14,162,390

G

proteasome 26S subunit, non-ATPase 10

decreases expression

ISO

Tamoxifen results in decreased expression of PSMD10 mRNA

NCBI chr X:109,445,291...109,453,605
Ensembl chr X:109,445,291...109,453,605

G

proteasome 26S subunit, non-ATPase 7

affects expression

ISO

Tamoxifen affects the expression of PSMD7 mRNA

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871

G

proline and serine rich coiled-coil 1

affects expression

ISO

Tamoxifen affects the expression of PSRC1 mRNA

NCBI chr 2:198,710,427...198,715,001
Ensembl chr 2:198,705,839...198,714,997

G

proline-serine-threonine phosphatase-interacting protein 1

affects expression

ISO

Tamoxifen affects the expression of PSTPIP1 mRNA

NCBI chr 8:65,395,328...65,434,616
Ensembl chr 8:65,395,358...65,434,627

G

polypyrimidine tract binding protein 2

affects expression

ISO

Tamoxifen affects the expression of PTBP2 mRNA

NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:210,497,706...210,558,291

G

polypyrimidine tract binding protein 3

affects expression

ISO

Tamoxifen affects the expression of PTBP3 mRNA

NCBI chr 5:79,108,376...79,194,533
Ensembl chr 5:79,108,376...79,194,508

G

patched 1

affects expression

ISO

Tamoxifen affects the expression of PTCH1 mRNA

NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,548,449...1,613,461

G

phosphatase and tensin homolog

increases response to substance

ISO

PTEN protein results in increased susceptibility to Tamoxifen

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

phosphotriesterase related

decreases expression

ISO

Tamoxifen results in decreased expression of PTER mRNA

NCBI chr17:80,967,463...81,028,707
Ensembl chr17:80,967,477...81,030,099

G

prostaglandin D2 synthase

affects expression
increases expression

ISO

Tamoxifen affects the expression of PTGDS mRNA
Tamoxifen results in increased expression of PTGDS mRNA

PMID:17555576 PMID:25123088

NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978

G

prostaglandin E receptor 2

affects expression

ISO

Tamoxifen affects the expression of PTGER2 mRNA

NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950

G

prostaglandin E receptor 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA

NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846

G

prostaglandin E receptor 4

affects expression

ISO

Tamoxifen affects the expression of PTGER4 mRNA

NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135

G

prostaglandin E synthase

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGES mRNA
Tamoxifen affects the expression of PTGES mRNA

PMID:17555576 PMID:19059307

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin reductase 3

affects expression

ISO

Tamoxifen affects the expression of PTGR3 mRNA

NCBI chr18:79,729,282...79,738,632
Ensembl chr18:79,729,282...79,738,632

G

prostaglandin-endoperoxide synthase 2

decreases response to substance
multiple interactions

ISO

PTGS2 protein results in decreased susceptibility to Tamoxifen
Tamoxifen inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
[PTGS2 protein results in increased chemical synthesis of Dinoprostone] which results in decreased susceptibility to Tamoxifen; [Tamoxifen co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; [Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA; FOXL2 protein inhibits the reaction [[Tamoxifen results in increased activity of ESR1 protein] which results in increased expression of PTGS2 mRNA]; Tamoxifen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]

PMID:15256495 PMID:15489888 PMID:16127422 PMID:19059307 PMID:19347870 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone

multiple interactions
decreases expression

EXP

gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of PTH protein]

NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:176,943,102...176,946,034

G

parathyroid hormone-like hormone

increases secretion
affects expression

ISO

Tamoxifen results in increased secretion of PTHLH protein
Tamoxifen affects the expression of PTHLH mRNA

PMID:9790998 PMID:14699072

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

protein tyrosine kinase 2

affects expression

ISO

Tamoxifen affects the expression of PTK2 mRNA

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

protein tyrosine kinase 2 beta

decreases expression

ISO

Tamoxifen results in decreased expression of PTK2B mRNA

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

protein tyrosine kinase 6

decreases expression

ISO

Tamoxifen results in decreased expression of PTK6 mRNA

NCBI chr 3:188,684,633...188,693,224
Ensembl chr 3:188,684,633...188,693,224

G

parathymosin

affects expression

ISO

Tamoxifen affects the expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212

G

pleiotrophin

affects expression

ISO

Tamoxifen affects the expression of PTN mRNA

PMID:14699072 PMID:17555576

NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482

G

protein tyrosine phosphatase 4A1

affects expression

ISO

Tamoxifen affects the expression of PTP4A1 mRNA

NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176

G

protein tyrosine phosphatase 4A3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA

NCBI chr 7:107,518,220...107,549,949
Ensembl chr 7:107,541,047...107,549,949

G

protein tyrosine phosphatase, non-receptor type 1

affects expression

ISO

Tamoxifen affects the expression of PTPN1 mRNA

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

G

protein tyrosine phosphatase, non-receptor type 13

affects expression

ISO

Tamoxifen affects the expression of PTPN13 mRNA

NCBI chr14:6,412,841...6,587,238
Ensembl chr14:6,412,841...6,587,171

G

protein tyrosine phosphatase, non-receptor type 21

affects expression

ISO

Tamoxifen affects the expression of PTPN21 mRNA

NCBI chr 6:123,662,783...123,727,809
Ensembl chr 6:123,662,783...123,727,809

G

protein tyrosine phosphatase, non-receptor type 23

affects expression

ISO

Tamoxifen affects the expression of PTPN23 mRNA

NCBI chr 8:119,239,213...119,261,675
Ensembl chr 8:119,239,213...119,261,675

G

protein tyrosine phosphatase, non-receptor type 4

affects expression

ISO

Tamoxifen affects the expression of PTPN4 mRNA

NCBI chr13:33,324,808...33,504,957
Ensembl chr13:33,324,808...33,504,957

G

protein tyrosine phosphatase, non-receptor type 5

increases expression

ISO

Tamoxifen results in increased expression of PTPN5 mRNA

NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:106,756,896...106,816,828

G

protein tyrosine phosphatase, receptor type, A

affects expression

ISO

Tamoxifen affects the expression of PTPRA mRNA

NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126

G

protein tyrosine phosphatase, receptor type, E

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of PTPRE mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of PTPRE mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:199,774,195...199,924,646
Ensembl chr 1:199,774,198...199,922,242

G

protein tyrosine phosphatase, receptor type, H

multiple interactions
affects expression

ISO

ESR2 protein affects the reaction [Tamoxifen results in decreased expression of PTPRH mRNA]
Tamoxifen affects the expression of PTPRH mRNA

NCBI chr 1:78,272,414...78,318,977
Ensembl chr 1:78,271,276...78,318,977

G

protein tyrosine phosphatase, receptor type, O

multiple interactions
increases expression
increases response to substance

ISO

ESR2 protein affects the reaction [Tamoxifen results in increased expression of PTPRO mRNA]; Tamoxifen promotes the reaction [ESR2 protein binds to [[FOS protein binds to JUN protein] which binds to PTPRO promoter]]
PTPRO protein results in increased susceptibility to Tamoxifen

NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:171,895,232...172,105,903

G

protein tyrosine phosphatase, receptor type, S

affects expression

ISO

Tamoxifen affects the expression of PTPRS mRNA

NCBI chr 9:1,332,558...1,394,161
Ensembl chr 9:1,332,559...1,394,093

G

6-pyruvoyl-tetrahydropterin synthase

affects expression

ISO

Tamoxifen affects the expression of PTS mRNA

NCBI chr 8:59,767,234...59,774,265
Ensembl chr 8:59,765,185...59,774,265

G

PTTG1 regulator of sister chromatid separation, securin

affects expression

ISO

Tamoxifen affects the expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

pentraxin 3

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

pseudouridine 5'-phosphatase

affects expression

ISO

Tamoxifen affects the expression of PUDP mRNA

NCBI chr18:46,064,867...46,067,247
Ensembl chr18:46,063,292...46,067,443

G

poly-U binding splicing factor 60

affects expression

ISO

Tamoxifen affects the expression of PUF60 mRNA

NCBI chr 7:109,663,490...109,674,443
Ensembl chr 7:109,663,490...109,674,724

G

pumilio RNA-binding family member 2

affects expression

ISO

Tamoxifen affects the expression of PUM2 mRNA

NCBI chr 6:37,182,130...37,262,223
Ensembl chr 6:37,182,013...37,262,223

G

PWWP domain containing 2B

affects expression

ISO

Tamoxifen affects the expression of PWWP2B mRNA

NCBI chr 1:203,470,172...203,489,575
Ensembl chr 1:203,470,928...203,489,549

G

PX domain containing serine/threonine kinase like

affects expression

ISO

Tamoxifen affects the expression of PXK mRNA

NCBI chr15:19,190,085...19,258,711
Ensembl chr15:19,190,085...19,258,671

G

peroxisomal membrane protein 4

affects expression

ISO

Tamoxifen affects the expression of PXMP4 mRNA

NCBI chr 3:163,553,582...163,570,829
Ensembl chr 3:163,553,599...163,570,829

G

pyrroline-5-carboxylate reductase 1

affects expression
increases expression

ISO

Tamoxifen affects the expression of PYCR1 mRNA
Tamoxifen results in increased expression of PYCR1 mRNA

PMID:17555576 PMID:25123088

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

pyrroline-5-carboxylate reductase 2

affects expression

ISO

Tamoxifen affects the expression of PYCR2 mRNA

NCBI chr13:95,158,236...95,162,030
Ensembl chr13:95,158,183...95,162,029

G

glycogen phosphorylase, muscle associated

affects expression

ISO

Tamoxifen affects the expression of PYGM mRNA

NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:213,119,791...213,134,612

G

pygopus family PHD finger 1

decreases expression

ISO

Tamoxifen results in decreased expression of PYGO1 mRNA

NCBI chr 8:82,546,866...82,565,526
Ensembl chr 8:82,546,848...82,565,523

G

QKI, KH domain containing RNA binding

affects expression

ISO

Tamoxifen affects the expression of QKI mRNA

NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:52,935,382...53,047,337

G

queuine tRNA-ribosyltransferase catalytic subunit 1

increases expression

ISO

Tamoxifen results in increased expression of QTRT1 mRNA

NCBI chr 8:28,239,993...28,249,983
Ensembl chr 8:28,242,472...28,250,398

G

RAB1A, member RAS oncogene family

affects expression

ISO

Tamoxifen affects the expression of RAB1A mRNA

NCBI chr14:98,623,582...98,648,766
Ensembl chr14:98,623,635...98,661,582

G

RAB29, member RAS oncogene family

affects expression

ISO

Tamoxifen affects the expression of RAB29 mRNA

NCBI chr13:45,859,930...45,865,468
Ensembl chr13:45,859,961...45,865,610

G

RAB30, member RAS oncogene family

affects expression

ISO

Tamoxifen affects the expression of RAB30 mRNA

NCBI chr 1:156,216,137...156,310,778
Ensembl chr 1:156,216,137...156,310,778

G

RAB31, member RAS oncogene family

affects expression

ISO

Tamoxifen affects the expression of RAB31 mRNA

NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:112,693,597...112,828,092

G

RAB32, member RAS oncogene family

affects expression
decreases expression

ISO

Tamoxifen affects the expression of RAB32 mRNA
Tamoxifen results in decreased expression of RAB32 mRNA

PMID:20937368 PMID:25123088

NCBI chr 1:6,766,448...6,781,258
Ensembl chr 1:6,766,455...6,781,258

G

Rab40c, member RAS oncogene family

increases expression

ISO

Tamoxifen results in increased expression of RAB40C mRNA

NCBI chr10:15,405,436...15,440,659

G

RAB5A, member RAS oncogene family

affects expression

ISO

Tamoxifen affects the expression of RAB5A mRNA

NCBI chr 9:6,720,057...6,749,456
Ensembl chr 9:6,721,122...6,749,447

G

Rab geranylgeranyltransferase subunit beta

affects expression

ISO

Tamoxifen affects the expression of RABGGTB mRNA

NCBI chr 2:245,504,586...245,510,878
Ensembl chr 2:245,504,586...245,510,774

G

Rac GTPase-activating protein 1

affects expression

ISO

Tamoxifen affects the expression of RACGAP1 mRNA

NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:132,620,595...132,659,738

G

RAD51 recombinase

decreases expression

EXP

Tamoxifen results in decreased expression of RAD51 protein

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

RAD51 associated protein 1

affects expression

ISO

Tamoxifen affects the expression of RAD51AP1 mRNA

NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680

G

RAD51 paralog B

affects expression

ISO

Tamoxifen affects the expression of RAD51B mRNA

NCBI chr 6:103,829,390...104,373,923
Ensembl chr 6:103,829,554...104,374,509

G

Ral GTPase activating protein catalytic subunit alpha 1

affects expression

ISO

Tamoxifen affects the expression of RALGAPA1 mRNA

NCBI chr 6:78,712,554...78,987,486
Ensembl chr 6:78,701,832...78,987,486

G

ral guanine nucleotide dissociation stimulator

affects expression

ISO

Tamoxifen affects the expression of RALGDS mRNA

NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:32,237,786...32,278,045

G

ral guanine nucleotide dissociation stimulator like 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA

NCBI chr13:67,184,402...67,454,019
Ensembl chr13:67,184,402...67,454,019

G

Ral GEF with PH domain and SH3 binding motif 1

affects expression

ISO

Tamoxifen affects the expression of RALGPS1 mRNA

NCBI chr 3:36,831,029...37,067,659
Ensembl chr 3:36,831,029...37,067,659

G

receptor activity modifying protein 1

affects expression

ISO

Tamoxifen affects the expression of RAMP1 mRNA

NCBI chr 9:99,213,031...99,263,696

G

RAN, member RAS oncogene family

increases expression

ISO
EXP

Tamoxifen results in increased expression of RAN mRNA

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317

G

RAN binding protein 1

affects expression

ISO

Tamoxifen affects the expression of RANBP1 mRNA

NCBI chr11:96,246,912...96,255,145
Ensembl chr11:96,246,740...96,255,145

G

RAN GTPase activating protein 1

affects expression

ISO

Tamoxifen affects the expression of RANGAP1 mRNA

NCBI chr 7:115,104,820...115,130,564
Ensembl chr 7:115,104,823...115,130,564

G

RAN guanine nucleotide release factor

affects expression

ISO

Tamoxifen affects the expression of RANGRF mRNA

NCBI chr10:54,176,325...54,177,696
Ensembl chr10:54,176,325...54,177,696

G

receptor-associated protein of the synapse

affects expression

ISO

Tamoxifen affects the expression of RAPSN mRNA

NCBI chr 3:97,470,891...97,480,196
Ensembl chr 3:97,470,881...97,480,196

G

retinoic acid receptor, alpha

affects expression

ISO

Tamoxifen affects the expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

arginyl-tRNA synthetase 1

affects expression

ISO

Tamoxifen affects the expression of RARS1 mRNA

NCBI chr10:20,774,804...20,799,251
Ensembl chr10:20,774,805...20,799,251

G

RAS p21 protein activator 1

affects expression

ISO

Tamoxifen affects the expression of RASA1 mRNA

NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161

G

RAS p21 protein activator 2

affects expression

ISO

Tamoxifen affects the expression of RASA2 mRNA

NCBI chr 8:105,996,797...106,116,285
Ensembl chr 8:106,000,002...106,116,206

G

RAS protein activator like 1

affects expression

ISO

Tamoxifen affects the expression of RASA4 mRNA

NCBI chr12:41,541,865...41,574,957
Ensembl chr12:41,541,865...41,574,315

G

RAS and EF hand domain containing

decreases expression

ISO

Tamoxifen results in decreased expression of RASEF mRNA

NCBI chr 5:92,595,148...92,665,526
Ensembl chr 5:92,595,148...92,666,117

G

RasGEF domain family, member 1C

decreases expression

ISO

Tamoxifen results in decreased expression of RASGEF1C mRNA

NCBI chr10:34,728,573...34,794,763
Ensembl chr10:34,728,573...34,794,763

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression

ISO

Tamoxifen affects the expression of RASGRF1 mRNA

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

RAS guanyl releasing protein 1

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA

NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434

G

Ras interacting protein 1

affects expression

ISO

Tamoxifen affects the expression of RASIP1 mRNA

NCBI chr 1:105,233,599...105,246,028
Ensembl chr 1:105,233,599...105,246,028

G

RAS-like family 11 member B

affects expression

ISO

Tamoxifen affects the expression of RASL11B mRNA

NCBI chr14:34,369,029...34,373,250
Ensembl chr14:34,368,726...34,373,250

G

Ras association domain family member 1

affects expression

ISO

Tamoxifen affects the expression of RASSF1 mRNA

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

Ras association domain family member 5

affects expression

ISO

Tamoxifen affects the expression of RASSF5 mRNA

NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277

G

Ras association domain family member 7

affects expression

ISO

Tamoxifen affects the expression of RASSF7 mRNA

NCBI chr 1:205,749,173...205,753,350
Ensembl chr 1:205,747,654...205,753,360

G

RB transcriptional corepressor 1

multiple interactions
decreases expression
increases phosphorylation
decreases phosphorylation

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in decreased phosphorylation of RB1 protein]; [Tamoxifen co-treated with FTI 277] results in decreased phosphorylation of RB1 protein
[Tamoxifen results in increased expression of MIR106A mRNA] which results in decreased expression of RB1 protein
Tamoxifen results in decreased expression of RB1 protein
Tamoxifen results in increased phosphorylation of RB1 protein

PMID:12866041 PMID:14645110 PMID:15642790 PMID:17343880

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RB binding protein 6, ubiquitin ligase

affects expression

ISO

Tamoxifen affects the expression of RBBP6 mRNA

NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852

G

RANBP2-type and C3HC4-type zinc finger containing 1

affects expression

ISO

Tamoxifen affects the expression of RBCK1 mRNA

NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:161,249,390...161,266,032

G

RB transcriptional corepressor like 1

increases phosphorylation

ISO

Tamoxifen results in increased phosphorylation of RBL1 protein

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

RB transcriptional corepressor like 2

multiple interactions

ISO

[Tamoxifen co-treated with FTI 277] results in decreased phosphorylation of RBL2 protein

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411

G

RNA binding motif protein 17

multiple interactions

ISO

Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:71,846,941...71,863,834
Ensembl chr17:71,846,916...71,864,431

G

RNA binding motif protein 20

increases expression

ISO

Tamoxifen results in increased expression of RBM20 mRNA

NCBI chr 1:262,671,311...262,912,551
Ensembl chr 1:262,688,978...262,891,364

G

RNA binding motif protein 24

increases expression

ISO

Tamoxifen results in increased expression of RBM24 mRNA

NCBI chr17:18,481,893...18,494,440
Ensembl chr17:18,481,900...18,494,604

G

RNA binding motif protein 3

affects expression
increases expression

ISO

Tamoxifen affects the expression of RBM3 mRNA
Tamoxifen results in increased expression of RBM3 mRNA

PMID:17555576 PMID:25123088

NCBI chr X:17,020,863...17,024,341
Ensembl chr X:17,020,864...17,024,841

G

RNA binding motif protein 39

affects expression

ISO

Tamoxifen affects the expression of RBM39 mRNA

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

RNA binding motif protein 8A

affects expression

ISO

Tamoxifen affects the expression of RBM8A mRNA

NCBI chr 2:186,854,018...186,856,802
Ensembl chr 2:186,854,036...186,856,802

G

RNA binding motif, single stranded interacting protein 3

affects expression

ISO

Tamoxifen affects the expression of RBMS3 mRNA

NCBI chr 8:125,183,311...125,970,239
Ensembl chr 8:125,183,315...126,503,586

G

retinol binding protein 4

affects expression

ISO

Tamoxifen affects the expression of RBP4 mRNA

NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898

G

RNA binding protein, mRNA processing factor

affects expression

ISO

Tamoxifen affects the expression of RBPMS mRNA

PMID:14699072 PMID:17555576

NCBI chr16:64,942,159...65,098,504
Ensembl chr16:64,942,530...65,098,503

G

ring-box 1

affects expression

ISO

Tamoxifen affects the expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

regulator of calcineurin 1

increases expression
affects expression

ISO

Tamoxifen results in increased expression of RCAN1 mRNA
Tamoxifen affects the expression of RCAN1 mRNA

PMID:15604281 PMID:20937368

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236

G

regulator of calcineurin 2

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA
Tamoxifen results in decreased expression of RCAN2 mRNA

PMID:19059307 PMID:25123088

NCBI chr 9:24,456,861...24,674,234
Ensembl chr 9:24,456,861...24,672,189

G

RCC1 and BTB domain containing protein 2

affects expression

ISO

Tamoxifen affects the expression of RCBTB2 mRNA

NCBI chr15:54,729,367...54,774,004
Ensembl chr15:54,729,332...54,793,313

G

REST corepressor 1

affects expression

ISO

Tamoxifen affects the expression of RCOR1 mRNA

NCBI chr 6:135,890,851...135,967,367
Ensembl chr 6:135,890,851...135,967,367

G

REST corepressor 3

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA
Tamoxifen affects the expression of RCOR3 mRNA

PMID:17555576 PMID:19059307

NCBI chr13:106,156,166...106,196,542
Ensembl chr13:106,157,232...106,196,575

G

RD3 regulator of GUCY2D

decreases expression

ISO

Tamoxifen results in decreased expression of RD3 mRNA

NCBI chr13:106,060,657...106,097,063
Ensembl chr13:106,084,171...106,093,540

G

retinol dehydrogenase 10

affects expression

ISO

Tamoxifen affects the expression of RDH10 mRNA

NCBI chr 5:7,969,931...7,998,834
Ensembl chr 5:7,971,705...7,999,019

G

receptor accessory protein 3

affects expression

ISO

Tamoxifen affects the expression of REEP3 mRNA

NCBI chr20:21,492,695...21,575,138
Ensembl chr20:21,492,721...21,577,521

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; RELA protein inhibits the reaction [Tamoxifen results in decreased expression of BCL2 protein]; Tamoxifen affects the localization of and results in decreased activity of RELA protein; Tamoxifen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Tamoxifen inhibits the reaction [TNF protein results in increased activity of RELA protein]

PMID:15489888 PMID:16497877 PMID:20154269

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

ISO

Tamoxifen inhibits the reaction [EGF protein results in increased expression of RELB mRNA]

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

arginine-glutamic acid dipeptide repeats

affects expression

ISO

Tamoxifen affects the expression of RERE mRNA

NCBI chr 5:166,048,770...166,380,559
Ensembl chr 5:166,048,844...166,380,558

G

RAS-like, estrogen-regulated, growth-inhibitor

increases expression

ISO

Tamoxifen results in increased expression of RERG mRNA

NCBI chr 4:171,712,794...171,821,268
Ensembl chr 4:171,712,794...171,820,903

G

ret proto-oncogene

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of RET mRNA; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of RET mRNA; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of RET mRNA]

PMID:19059307 PMID:24758408

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556

G

reticulophagy regulator 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA
Tamoxifen affects the expression of RETREG1 mRNA

PMID:17555576 PMID:19059307 PMID:20937368

NCBI chr 2:78,045,435...78,205,316
Ensembl chr 2:78,066,031...78,225,356

G

RNA exonuclease 2

affects expression

ISO

Tamoxifen affects the expression of SMFN mRNA

NCBI chr 8:57,708,420...57,720,142
Ensembl chr 8:57,707,558...57,720,142

G

riboflavin kinase

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of RFK mRNA
[Tamoxifen co-treated with ESR2 protein] results in increased expression of RFK mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:224,226,632...224,234,185
Ensembl chr 1:224,226,628...224,235,698
Ensembl chr X:224,226,628...224,235,698

G

raftlin lipid raft linker 1

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA
Tamoxifen affects the expression of RFTN1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:18,302,143...18,499,819
Ensembl chr 9:18,285,934...18,499,819

G

regulatory factor X2

increases expression

ISO

Tamoxifen results in increased expression of RFX2 mRNA

NCBI chr 9:1,691,762...1,759,159
Ensembl chr 9:1,690,612...1,758,529

G

regulator of G-protein signaling 10

affects expression

ISO

Tamoxifen affects the expression of RGS10 mRNA

NCBI chr 1:192,376,772...192,422,640
Ensembl chr 1:192,376,774...192,418,904

G

regulator of G-protein signaling 11

affects expression

ISO

Tamoxifen affects the expression of RGS11 mRNA

NCBI chr10:15,727,279...15,735,536
Ensembl chr10:15,727,279...15,735,536

G

regulator of G-protein signaling 12

increases expression

ISO

Tamoxifen results in increased expression of RGS12 mRNA

NCBI chr14:79,940,561...80,048,637
Ensembl chr14:79,940,565...80,034,859

G

regulator of G-protein signaling 13

affects expression

ISO

Tamoxifen affects the expression of RGS13 mRNA

NCBI chr13:58,472,604...58,505,922
Ensembl chr13:58,472,604...58,505,922

G

regulator of G-protein signaling 16

multiple interactions
affects expression

ISO

[Tamoxifen co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA
Tamoxifen affects the expression of RGS16 mRNA

PMID:19059307 PMID:20937368

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

regulator of G-protein signaling 2

affects expression

ISO

Tamoxifen affects the expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

regulator of G-protein signaling 4

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of RGS4 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Tamoxifen co-treated with ESR2 protein] results in increased expression of RGS4 mRNA

PMID:14699072 PMID:19059307

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

regulator of G-protein signaling 5

affects expression

ISO

Tamoxifen affects the expression of RGS5 mRNA

NCBI chr13:84,381,077...84,417,875
Ensembl chr13:84,380,910...84,421,352

G

regulator of G-protein signaling 7 binding protein

increases expression

ISO

Tamoxifen results in increased expression of RGS7BP mRNA

NCBI chr 2:37,867,698...37,965,587
Ensembl chr 2:37,872,949...37,965,253

G

regulator of G-protein signaling 9

decreases expression

ISO

Tamoxifen results in decreased expression of RGS9 mRNA

NCBI chr10:94,696,556...94,770,387
Ensembl chr10:94,696,556...94,770,387

G

regulator of G protein signaling 9 binding protein

increases expression

ISO

Tamoxifen results in increased expression of RGS9BP mRNA

NCBI chr 1:97,386,326...97,387,039
Ensembl chr 1:97,386,326...97,387,039

G

Rh family B glycoprotein

decreases expression

ISO

Tamoxifen results in decreased expression of RHBG mRNA

NCBI chr 2:176,002,886...176,015,201
Ensembl chr 2:176,002,887...176,015,609

G

ras homolog family member B

increases expression

ISO

Tamoxifen results in increased expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

Rho-related BTB domain containing 3

affects expression
multiple interactions

ISO

Tamoxifen affects the expression of RHOBTB3 mRNA
[Tamoxifen co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:7,094,972...7,201,507
Ensembl chr 2:7,095,253...7,150,906

G

ras homolog family member F, filopodia associated

multiple interactions

ISO

[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RHOF mRNA

NCBI chr12:39,082,413...39,107,528
Ensembl chr12:39,091,979...39,107,528

G

ras homolog family member Q

affects expression

ISO

Tamoxifen affects the expression of RHOQ mRNA

NCBI chr 6:13,368,499...13,403,929
Ensembl chr 1:115,757,909...115,759,467

G

ras homolog family member U

increases expression

ISO

Tamoxifen results in increased expression of RHOU mRNA

NCBI chr19:68,538,960...68,548,733
Ensembl chr19:68,538,960...68,548,733

G

rhophilin, Rho GTPase binding protein 2

affects expression

ISO

Tamoxifen affects the expression of RHPN2 mRNA

NCBI chr 1:97,128,054...97,188,803
Ensembl chr 1:97,127,697...97,188,803

G

receptor-interacting serine-threonine kinase 3

affects expression

ISO

Tamoxifen affects the expression of RIPK3 mRNA

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

RHO family interacting cell polarization regulator 2

multiple interactions

ISO

[Tamoxifen co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA

NCBI chr17:40,751,771...40,975,611
Ensembl chr17:40,751,771...40,975,337

G

retinaldehyde binding protein 1

affects expression

ISO

Tamoxifen affects the expression of RLBP1 mRNA

NCBI chr 1:142,718,262...142,731,621
Ensembl chr 1:142,718,262...142,731,621

G

ribonuclease T2

affects expression

ISO

Tamoxifen affects the expression of RNASET2 mRNA

NCBI chr 1:55,133,532...55,150,701
Ensembl chr 1:55,117,492...55,150,701

G

Rho family GTPase 2

decreases expression

ISO

Tamoxifen results in decreased expression of RND2 mRNA

NCBI chr10:86,899,395...86,902,992
Ensembl chr10:86,899,395...86,902,992

G

Rho family GTPase 3

increases expression

ISO

Tamoxifen results in increased expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536

G

ring finger protein 126

affects expression

ISO

Tamoxifen affects the expression of RNF126 mRNA

NCBI chr 7:10,590,013...10,597,585
Ensembl chr 7:10,590,039...10,598,132

G

ring finger protein 13

affects expression

ISO

Tamoxifen affects the expression of RNF13 mRNA

NCBI chr 2:144,076,526...144,211,520
Ensembl chr 2:144,077,916...144,211,798

G

ring finger protein 144A

increases expression

ISO

Tamoxifen results in increased expression of RNF144A mRNA

NCBI chr 6:48,628,241...48,748,241
Ensembl chr 6:48,631,648...48,748,179

G

ring finger protein 145

increases expression

ISO

Tamoxifen results in increased expression of RNF145 mRNA

NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,507,772...29,552,151

G

ring finger protein 146

affects expression

ISO

Tamoxifen affects the expression of RNF146 mRNA

NCBI chr 1:30,286,680...30,304,367
Ensembl chr 1:30,287,511...30,304,361

G

ring finger protein 186

affects expression
increases expression

ISO

Tamoxifen affects the expression of RNF186 mRNA
Tamoxifen results in increased expression of RNF186 mRNA

PMID:17555576 PMID:20937368

NCBI chr 5:156,493,750...156,494,974
Ensembl chr 5:156,493,752...156,494,978

G

ring finger protein 215

affects expression

ISO

Tamoxifen affects the expression of RNF215 mRNA

NCBI chr14:83,230,234...83,236,668
Ensembl chr14:83,230,265...83,236,668

G

ring finger protein 43

affects expression

ISO

Tamoxifen affects the expression of RNF43 mRNA

NCBI chr10:72,958,744...73,034,540
Ensembl chr10:72,961,641...73,034,551

G

ring finger protein 7

affects expression

ISO

Tamoxifen affects the expression of RNF7 mRNA

NCBI chr 8:105,918,395...105,927,643
Ensembl chr 8:105,918,395...105,927,405

G

ribonuclease/angiogenin inhibitor 1

affects expression

ISO

Tamoxifen affects the expression of RNH1 mRNA

NCBI chr 1:205,698,882...205,711,348
Ensembl chr 1:205,698,882...205,711,582

G

arginyl aminopeptidase

affects expression

ISO

Tamoxifen affects the expression of RNPEP mRNA

NCBI chr13:49,251,259...49,271,440
Ensembl chr13:49,251,264...49,269,799

G

rhophilin associated tail protein 1-like

decreases expression

ISO

Tamoxifen results in decreased expression of ROPN1L mRNA

NCBI chr 2:84,153,529...84,164,216
Ensembl chr 2:84,153,529...84,164,415

G

RAR-related orphan receptor A

affects expression
decreases activity

ISO

Tamoxifen affects the expression of RORA mRNA
Tamoxifen results in decreased activity of RORA protein

PMID:17555576 PMID:20937368

NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730

G

replication protein A3

affects expression

ISO

Tamoxifen affects the expression of RPA3 mRNA

NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:37,270,966...37,274,183

G

RNA polymerase II associated protein 3

increases expression