mitoxantrone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	mitoxantrone	go back to main search page
Accession:	CHEBI:50729	browse the term
Definition:	A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Synonyms:	exact_synonym:	1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione
	related_synonym:	1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE; Formula=C22H28N4O6; InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2; InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N; SMILES=OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12; mitoxantrona; mitoxantronum
	alt_id:	CHEBI:43919; CHEBI:6955
	xref:	Beilstein:2795126; CAS:65271-80-9; DrugBank:DB01204; Drug_Central:1821; KEGG:C11195; KEGG:D08224; LINCS:LSM-2481
	xref_mesh:	MESH:D008942
	xref:	PDBeChem:MIX; Patent:DE2835661; Patent:US4197249; Wikipedia:Mitoxantrone

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Genes (256)

mitoxantrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects response to substance

ABCA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression

Mitoxantrone results in increased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 2

affects export
affects uptake
affects transport
increases response to substance
multiple interactions
decreases response to substance
decreases abundance
increases expression
increases export
increases transport
affects response to substance

ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the uptake of Mitoxantrone
ABCG2 protein affects the transport of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone
oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]
ABCG2 protein results in decreased susceptibility to Mitoxantrone
ABCG2 protein results in decreased abundance of Mitoxantrone
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in increased export of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [GSK 1363089 results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; GSK 1363089 inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
ABCG2 protein affects the susceptibility to Mitoxantrone

PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acyl-CoA dehydrogenase, very long chain

decreases expression

Mitoxantrone results in decreased expression of ACADVL protein

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

acyl-CoA synthetase long-chain family member 3

affects response to substance

ACSL3 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

actin, alpha 1, skeletal muscle

decreases expression

Mitoxantrone results in decreased expression of ACTA1 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin gamma 2, smooth muscle

affects response to substance

ACTG2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

adenosine deaminase, RNA-specific, B1

affects response to substance

ADARB1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852

G

1-acylglycerol-3-phosphate O-acyltransferase 5

affects response to substance

AGPAT5 protein affects the susceptibility to Mitoxantrone

NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560

G

adenosylhomocysteinase-like 1

affects response to substance

AHCYL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

G

aldehyde dehydrogenase 2 family member

affects response to substance

ALDH2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

angiomotin-like 1

affects response to substance

AMOTL1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573

G

ankyrin 2

decreases expression

Mitoxantrone results in decreased expression of ANK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

G

asparagine synthetase (glutamine-hydrolyzing)

affects response to substance

ASNS protein affects the susceptibility to Mitoxantrone

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

affects response to substance

ASS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

autophagy related 5

decreases expression

Mitoxantrone results in decreased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATM serine/threonine kinase

decreases expression
multiple interactions
increases phosphorylation

Mitoxantrone results in decreased expression of ATM mRNA
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein
Mitoxantrone results in increased phosphorylation of ATM protein

PMID:22832221 PMID:29913208

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

Mitoxantrone results in decreased expression of ATP1A2 mRNA

PMID:26537877 PMID:28940058

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATP synthase F1 subunit alpha

decreases expression

Mitoxantrone results in decreased expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

decreases expression

Mitoxantrone results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase F1 subunit gamma

decreases expression

Mitoxantrone results in decreased expression of ATP5F1C protein

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATPase copper transporting alpha

decreases response to substance

ATP7A protein results in decreased susceptibility to Mitoxantrone

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

beta-secretase 2

affects response to substance

BACE2 protein affects the susceptibility to Mitoxantrone

NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression

Mitoxantrone results in increased expression of BAX mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BBX high mobility group box domain containing

affects response to substance

BBX protein affects the susceptibility to Mitoxantrone

NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251

G

basal cell adhesion molecule (Lutheran blood group)

affects response to substance

BCAM protein affects the susceptibility to Mitoxantrone

NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403

G

branched chain amino acid transaminase 1

increases expression

Mitoxantrone results in increased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA

PMID:8219202 PMID:8840993 PMID:15582267

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

decreases expression

Mitoxantrone results in decreased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 2

decreases expression

Mitoxantrone results in decreased expression of BIRC2 protein

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

affects expression
increases expression

Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 7

affects response to substance

BMP7 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

bone marrow stromal cell antigen 2

affects response to substance

BST2 protein affects the susceptibility to Mitoxantrone

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BTB domain containing 3

affects response to substance

BTBD3 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038

G

calcium voltage-gated channel subunit alpha1 G

decreases expression

Mitoxantrone results in decreased expression of CACNA1G mRNA

PMID:26537877 PMID:28940058

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

decreases expression

Mitoxantrone results in decreased expression of CACNA2D2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173

G

calreticulin

affects localization

Mitoxantrone affects the localization of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

affects response to substance

CAMK2N1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600

G

CASC3 exon junction complex subunit

affects response to substance

CASC3 mRNA affects the susceptibility to Mitoxantrone

NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966

G

caspase 2

increases expression
increases splicing

Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity

BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]

PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

increases activity

Mitoxantrone results in increased activity of CASP6 protein

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases activity
multiple interactions

Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]

PMID:12948851 PMID:22700542

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases activity

Mitoxantrone results in increased activity of CASP8 protein

PMID:12948851 PMID:32894303

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Mitoxantrone results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity

Mitoxantrone results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolae associated protein 3

affects response to substance

CAVIN3 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161

G

caveolae associated protein 4

decreases expression

Mitoxantrone results in decreased expression of CAVIN4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:62,996,906...63,007,677
Ensembl chr 5:62,996,865...63,007,678

G

CD55 molecule (Cromer blood group)

affects response to substance

CD55 protein affects the susceptibility to Mitoxantrone

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

CUGBP, Elav-like family member 2

affects response to substance

CELF2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

centrosomal protein 15

affects response to substance

CEP15 protein affects the susceptibility to Mitoxantrone

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

carboxylesterase 2H

affects response to substance

CES2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

chordin-like 1

affects response to substance

CHRDL1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921

G

chemokine-like factor

affects response to substance

CKLF protein affects the susceptibility to Mitoxantrone

NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570

G

creatine kinase, M-type

decreases expression

Mitoxantrone results in decreased expression of CKM mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

chloride nucleotide-sensitive channel 1A

affects response to substance

CLNS1A protein affects the susceptibility to Mitoxantrone

NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661

G

clusterin

affects response to substance

CLU protein affects the susceptibility to Mitoxantrone

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cochlin

affects response to substance

COCH protein affects the susceptibility to Mitoxantrone

NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109

G

collagen type XI alpha 1 chain

affects response to substance

COL11A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

corin, serine peptidase

decreases expression

Mitoxantrone results in decreased expression of CORIN mRNA

PMID:26537877 PMID:28940058

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503

G

carboxypeptidase, vitellogenic-like

affects response to substance

CPVL protein affects the susceptibility to Mitoxantrone

NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655

G

cAMP responsive element binding protein-like 2

affects response to substance

CREBL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292

G

citrate synthase

decreases activity

Mitoxantrone results in decreased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cysteine and serine rich nuclear protein 2

affects response to substance

CSRNP2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075

G

cystathionine gamma-lyase

affects response to substance

CTH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

CXADR, Ig-like cell adhesion molecule

affects response to substance

CXADR protein affects the susceptibility to Mitoxantrone

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Mitoxantrone results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Mitoxantrone results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

death associated protein kinase 1

affects response to substance

DAPK1 protein affects the susceptibility to Mitoxantrone

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

DNA-damage-inducible transcript 4

affects response to substance

DDIT4 protein affects the susceptibility to Mitoxantrone

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

dehydrogenase/reductase 2

affects response to substance

DHRS2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

affects response to substance

DIS3 protein affects the susceptibility to Mitoxantrone

NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642

G

dystrophin

decreases expression

Mitoxantrone results in decreased expression of DMD mRNA

PMID:26537877 PMID:28940058

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

dual specificity phosphatase 4

affects response to substance
increases expression

DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA

PMID:16217747 PMID:26537877 PMID:28940058

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity tyrosine phosphorylation regulated kinase 2

affects response to substance

DYRK2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106

G

early growth response 1

affects response to substance

EGR1 protein affects the susceptibility to Mitoxantrone

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 subunit alpha

affects response to substance

EIF2S1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 5A

affects response to substance

EIF5A protein affects the susceptibility to Mitoxantrone

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

ELAV like RNA binding protein 4

affects response to substance

ELAVL4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:125,056,848...125,200,543
Ensembl chr 5:125,056,848...125,200,446

G

ELOVL fatty acid elongase 5

affects response to substance

ELOVL5 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

engrailed homeobox 2

affects response to substance

EN2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943

G

ectodermal-neural cortex 1

affects response to substance

ENC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

erythrocyte membrane protein band 4.1-like 2

affects response to substance

EPB41L2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

decreases expression

Mitoxantrone results in decreased expression of ERBB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

electron transfer flavoprotein dehydrogenase

decreases expression

Mitoxantrone results in decreased expression of ETFDH protein

NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745

G

ecotropic viral integration site 5

affects response to substance

EVI5 protein affects the susceptibility to Mitoxantrone

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

exostosin-like glycosyltransferase 2

affects response to substance

EXTL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653

G

fatty acid binding protein 3

increases expression

Mitoxantrone results in increased expression of FABP3 protein

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

family with sequence similarity 117, member A

affects response to substance

FAM117A protein affects the susceptibility to Mitoxantrone

NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343

G

Fas cell surface death receptor

multiple interactions
increases expression

Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein

PMID:9676859 PMID:26537877 PMID:28940058

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases response to substance
multiple interactions

FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

farnesyl diphosphate farnesyl transferase 1

affects response to substance

FDFT1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

four and a half LIM domains 1

increases expression

Mitoxantrone results in increased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

fibronectin leucine rich transmembrane protein 3

affects response to substance

FLRT3 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

fibronectin type III domain containing 3a

affects response to substance

FNDC3A protein affects the susceptibility to Mitoxantrone

NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784

G

forkhead box F2

affects response to substance

FOXF2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

G

FYN proto-oncogene, Src family tyrosine kinase

affects response to substance

FYN protein affects the susceptibility to Mitoxantrone

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

frizzled class receptor 2

affects response to substance

FZD2 protein affects the susceptibility to Mitoxantrone

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

G

GTP cyclohydrolase 1

affects response to substance

GCH1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

growth differentiation factor 15

increases expression

Mitoxantrone results in increased expression of GDF15 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glutamate-ammonia ligase

affects response to substance

GLUL protein affects the susceptibility to Mitoxantrone

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutathione peroxidase 1

increases expression

Mitoxantrone results in increased expression of GPX1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

affects response to substance

GPX3 protein affects the susceptibility to Mitoxantrone

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

guanylate cyclase 1 soluble subunit beta 1

affects response to substance

GUCY1B1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

H2A.X variant histone

increases expression
multiple interactions
increases phosphorylation

Mitoxantrone results in increased expression of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]
Mitoxantrone results in increased phosphorylation of H2AX protein

PMID:19738048 PMID:24994473 PMID:29913208

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

Mitoxantrone results in decreased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histone deacetylase 4

affects response to substance

HDAC4 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

high mobility group 20 B

affects response to substance

HMG20B protein affects the susceptibility to Mitoxantrone

NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640

G

homeo box A5

affects response to substance

HOXA5 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234

G

histidine rich calcium binding protein

decreases expression

Mitoxantrone results in decreased expression of HRC mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984

G

heat shock protein family A (Hsp70) member 2

affects response to substance

HSPA2 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects response to substance
decreases expression

IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein

PMID:16217747 PMID:34246718

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

interferon induced transmembrane protein 1

affects response to substance

IFITM1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

insulin-like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Mitoxantrone

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2 mRNA binding protein 3

affects response to substance

IGF2BP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

insulin-like growth factor binding protein 3

affects response to substance

IGFBP3 protein affects the susceptibility to Mitoxantrone

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 7

affects response to substance

IGFBP7 protein affects the susceptibility to Mitoxantrone

NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314

G

interleukin 13 receptor subunit alpha 2

affects response to substance

IL13RA2 protein affects the susceptibility to Mitoxantrone

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

inner membrane mitochondrial protein

decreases expression

Mitoxantrone results in decreased expression of IMMT protein

NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109

G

IQ motif containing GTPase activating protein 1

affects response to substance

IQGAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

interferon regulatory factor 7

affects response to substance

IRF7 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

iroquois homeobox 1

affects response to substance

IRX1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444

G

iroquois homeobox 4

decreases expression

Mitoxantrone results in decreased expression of IRX4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549

G

ISG15 ubiquitin-like modifier

affects response to substance

ISG15 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

affects response to substance

ISG20 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

Janus kinase 2

decreases expression

Mitoxantrone results in decreased expression of JAK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

affects response to substance

KCNAB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243

G

potassium voltage-gated channel subfamily H member 2

decreases expression

Mitoxantrone results in decreased expression of KCNH2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 2

increases expression

Mitoxantrone results in increased expression of KCNJ2 mRNA

PMID:26537877 PMID:28940058

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

potassium voltage-gated channel subfamily Q member 1

decreases expression

Mitoxantrone results in decreased expression of KCNQ1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

G

KRR1, small subunit processome component homolog

affects response to substance

KRR1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985

G

laminin subunit alpha 2

affects response to substance

LAMA2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530

G

laminin subunit beta 1

affects response to substance

LAMB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit gamma 1

affects response to substance

LAMC1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

LBH regulator of WNT signaling pathway

affects response to substance

LBH protein affects the susceptibility to Mitoxantrone

NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079

G

LIM domain binding 3

decreases expression

Mitoxantrone results in decreased expression of LDB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532

G

LEM domain nuclear envelope protein 2

affects response to substance

LEMD2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626

G

leucine-rich repeat-containing G protein-coupled receptor 4

affects response to substance

LGR4 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899

G

lipase A, lysosomal acid type

affects response to substance

LIPA protein affects the susceptibility to Mitoxantrone

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

lipase G, endothelial type

affects response to substance

LIPG protein affects the susceptibility to Mitoxantrone

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

LIM and cysteine-rich domains 1

increases expression

Mitoxantrone results in increased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

lamin B1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

mono-ADP ribosylhydrolase 1

affects response to substance

MACROD1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716

G

MAF bZIP transcription factor F

affects response to substance

MAFF mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAGE family member D1

affects response to substance

MAGED1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:59,422,715...59,429,381
Ensembl chr X:59,422,717...59,429,364

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

malate dehydrogenase 2

decreases expression

Mitoxantrone results in decreased expression of MDH2 protein

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

MDM2 proto-oncogene

decreases response to substance

MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mesoderm specific transcript

affects response to substance

MEST protein affects the susceptibility to Mitoxantrone

NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145

G

molybdenum cofactor sulfurase

affects response to substance

MOCOS protein affects the susceptibility to Mitoxantrone

NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187

G

mitochondrial pyruvate carrier 2

affects response to substance

MPC2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

affects response to substance

MTHFD2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

MAX interactor 1, dimerization protein

affects response to substance

MXI1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
multiple interactions

Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYC binding protein 2

affects response to substance

MYCBP2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498

G

myosin heavy chain 6

decreases expression

Mitoxantrone results in decreased expression of MYH6 mRNA

PMID:26537877 PMID:28940058

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

decreases expression

Mitoxantrone results in decreased expression of MYH7 mRNA

PMID:26537877 PMID:28940058

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myomesin 2

decreases expression

Mitoxantrone results in decreased expression of MYOM2 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772

G

nicotinamide phosphoribosyltransferase

affects response to substance

NAMPT protein affects the susceptibility to Mitoxantrone

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

NADH:ubiquinone oxidoreductase subunit S5

affects response to substance

NDUFS5 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

neurofilament heavy chain

affects response to substance

NEFH protein affects the susceptibility to Mitoxantrone

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nidogen 2

affects response to substance

NID2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843

G

nuclear receptor subfamily 3, group C, member 1

decreases activity

Mitoxantrone results in decreased activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 2

affects response to substance

NR4A2 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nebulin-related anchoring protein

decreases expression

Mitoxantrone results in decreased expression of NRAP mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693

G

nuclear receptor interacting protein 1

affects response to substance

NRIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

3-oxoacid CoA transferase 1

affects response to substance

OXCT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714

G

prolyl 4-hydroxylase subunit alpha 1

affects response to substance

P4HA1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

parkin coregulated like

affects response to substance

PACRGL mRNA affects the susceptibility to Mitoxantrone

NCBI chr14:62,532,019...62,556,977
Ensembl chr14:62,532,030...62,556,993

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

PMID:8840993 PMID:15582267

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

PBX homeobox 1

affects response to substance

PBX1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594

G

phosphodiesterase 4D

affects response to substance

PDE4D protein affects the susceptibility to Mitoxantrone

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

phosphodiesterase 8A

affects response to substance

PDE8A protein affects the susceptibility to Mitoxantrone

NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

Mitoxantrone results in decreased expression of PDHA1 protein

NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311

G

prohibitin 2

decreases expression

Mitoxantrone results in decreased expression of PHB2 protein

NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272

G

phosphoglycerate dehydrogenase

affects response to substance

PHGDH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

PLAG1 like zinc finger 1

affects response to substance

PLAGL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228

G

plasminogen activator, tissue type

affects response to substance

PLAT protein affects the susceptibility to Mitoxantrone

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipase C, beta 4

affects response to substance

PLCB4 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392

G

pyridoxal phosphate binding protein

affects response to substance

PLPBP protein affects the susceptibility to Mitoxantrone

NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886

G

PML nuclear body scaffold

affects mutagenesis

Mitoxantrone affects the mutagenesis of PML gene

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

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protein phosphatase 1, regulatory (inhibitor) subunit 2

affects response to substance

PPP1R2 protein affects the susceptibility to Mitoxantrone

NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463

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protein phosphatase 1, regulatory subunit 3A

decreases expression

Mitoxantrone results in decreased expression of PPP1R3A mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638

G

PR/SET domain 16

decreases expression

Mitoxantrone results in decreased expression of PRDM16 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601

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peroxiredoxin 2

affects response to substance

PRDX2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

PRELI domain containing 3B

affects response to substance

PRELID3B protein affects the susceptibility to Mitoxantrone

NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181

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protein kinase cAMP-dependent X-linked catalytic subunit

increases expression

Mitoxantrone results in increased expression of PRKX mRNA

PMID:26537877 PMID:28940058

NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669

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protein tyrosine phosphatase, receptor type, E

affects response to substance

PTPRE protein affects the susceptibility to Mitoxantrone

NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534

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glycogen phosphorylase, muscle associated

decreases expression

Mitoxantrone results in decreased expression of PYGM mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

retinoic acid receptor, alpha

affects mutagenesis

Mitoxantrone affects the mutagenesis of RARA gene

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

Mitoxantrone results in increased expression of RARB mRNA alternative form

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RAS p21 protein activator 1

affects response to substance

RASA1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RB binding protein 8, endonuclease

affects response to substance

RBBP8 protein affects the susceptibility to Mitoxantrone

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RNA binding motif protein 17

multiple interactions
decreases response to substance

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014

G

RCC1 and BTB domain containing protein 1

affects response to substance

RCBTB1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:33,319,586...33,362,421
Ensembl chr15:33,319,586...33,365,302

G

ring finger and CHY zinc finger domain containing 1

affects response to substance

RCHY1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167

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regulator of G-protein signaling 2

affects response to substance

RGS2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

Rho family GTPase 1

increases expression

Mitoxantrone results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

Ras-related GTP binding D

affects response to substance

RRAGD mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356

G

RUNX family transcription factor 3

affects response to substance

RUNX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

ryanodine receptor 2

decreases expression

Mitoxantrone results in decreased expression of RYR2 mRNA

PMID:26537877 PMID:28940058

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

spalt-like transcription factor 2

affects response to substance

SALL2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:25,021,345...25,038,918
Ensembl chr15:25,021,345...25,038,918

G

SATB homeobox 2

affects response to substance

SATB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707

G

stearoyl-CoA desaturase

affects response to substance

SCD protein affects the susceptibility to Mitoxantrone

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

schwannomin interacting protein 1

affects response to substance

SCHIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585

G

sodium voltage-gated channel beta subunit 2

decreases expression

Mitoxantrone results in decreased expression of SCN2B mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765

G

sodium voltage-gated channel alpha subunit 5

decreases expression

Mitoxantrone results in decreased expression of SCN5A mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

syndecan 2

affects response to substance

SDC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

SEC31 homolog A, COPII coat complex component

affects response to substance

SEC31A protein affects the susceptibility to Mitoxantrone

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

serpin family E member 1

increases expression

Mitoxantrone results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

stratifin

affects response to substance

SFN protein affects the susceptibility to Mitoxantrone

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

secreted frizzled-related protein 4

affects response to substance

SFRP4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736

G

solute carrier family 16, member 6

affects response to substance

SLC16A6 protein affects the susceptibility to Mitoxantrone

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 25 member 11

decreases expression

Mitoxantrone results in decreased expression of SLC25A11 protein

NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410

G

solute carrier family 7 member 5

affects response to substance

SLC7A5 protein affects the susceptibility to Mitoxantrone

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family, member 4a1

affects response to substance

SLCO4A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

SMAD family member 2

affects response to substance

SMAD2 protein affects the susceptibility to Mitoxantrone

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

sorbin and SH3 domain containing 1

affects response to substance

SORBS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

spondin 1

affects response to substance

SPON1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

spondin 2

affects response to substance

SPON2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996

G

secreted phosphoprotein 1

increases expression

Mitoxantrone results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

affects expression
decreases expression

Mitoxantrone affects the expression of SQSTM1 protein
Mitoxantrone metabolite results in decreased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 1

affects response to substance

SRD5A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Mitoxantrone results in decreased expression of SUCLA2 protein

NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138

G

synaptotagmin-like 2

affects response to substance

SYTL2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:144,272,870...144,379,310
Ensembl chr 1:144,273,360...144,379,222

G

transgelin

affects response to substance

TAGLN protein affects the susceptibility to Mitoxantrone

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transporter 1, ATP binding cassette subfamily B member

affects response to substance

TAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

TBC1 domain family, member 8

affects response to substance

TBC1D8 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409

G

trefoil factor 3

affects response to substance

TFF3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor, beta 2

increases expression

Mitoxantrone results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

TIA1 cytotoxic granule-associated RNA binding protein

affects response to substance

TIA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586

G

TIMP metallopeptidase inhibitor 1

increases expression

Mitoxantrone results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

transmembrane protein 47

affects response to substance

TMEM47 protein affects the susceptibility to Mitoxantrone

NCBI chr X:45,421,405...45,447,900
Ensembl chr X:45,421,405...45,447,900

G

tankyrase

affects response to substance

TNKS protein affects the susceptibility to Mitoxantrone

NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260

G

troponin T1, slow skeletal type

decreases expression

Mitoxantrone results in decreased expression of TNNT1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721

G

tumor protein p53

affects activity

Mitoxantrone affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein D52

affects response to substance

TPD52 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622

G

tropomyosin 1

affects response to substance

TPM1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tribbles pseudokinase 1

affects response to substance

TRIB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731

G

tripartite motif-containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927

G

ubiquitin-like 3

affects response to substance

UBL3 protein affects the susceptibility to Mitoxantrone

NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862

G

ubiquitin C-terminal hydrolase L1

affects response to substance

UCHL1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

ubiquinol-cytochrome c reductase hinge protein

affects response to substance

UQCRH protein affects the susceptibility to Mitoxantrone

NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242

G

utrophin

affects response to substance

UTRN protein affects the susceptibility to Mitoxantrone

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

G

versican

affects response to substance

VCAN protein affects the susceptibility to Mitoxantrone

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

voltage-dependent anion channel 1

decreases expression

Mitoxantrone results in decreased expression of VDAC1 protein

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

tryptophanyl-tRNA synthetase 1

affects response to substance

WARS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WASH complex subunit 3

affects response to substance

WASHC3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:22,621,078...22,690,696

G

X-linked inhibitor of apoptosis

affects localization
decreases expression

Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

increases expression

Mitoxantrone results in increased expression of YWHAE protein

NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589

G

zinc finger AN1-type containing 1

affects response to substance

ZFAND1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:91,444,497...91,457,540
Ensembl chr 2:91,444,508...91,453,246

G

zinc finger, matrin type 3

increases expression

Mitoxantrone results in increased expression of ZMAT3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863

G

zinc finger and SCAN domain containing 18

affects response to substance

ZSCAN18 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
role	19850
biological role	19848
pharmacological role	19080
analgesic	14774
mitoxantrone	256
mitoxantrone dihydrochloride	0
Path 2
Term	Annotations
CHEBI ontology	19880
subatomic particle	19878
composite particle	19878
hadron	19878
baryon	19878
nucleon	19878
atomic nucleus	19878
atom	19878
main group element atom	19817
p-block element atom	19817
carbon group element atom	19757
carbon atom	19754
organic molecular entity	19754
heteroorganic entity	19512
organochalcogen compound	19275
organooxygen compound	19191
carbonyl compound	18914
ketone	17263
cyclic ketone	15911
quinone	9903
acenoquinone	7725
anthraquinone	518
hydroxyanthraquinones	506
dihydroxyanthraquinone	354
mitoxantrone	256
mitoxantrone dihydrochloride	0

paths to the root