|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
flavanone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
|
|
G |
Ar |
androgen receptor |
affects binding |
EXP |
flavanone binds to AR protein |
CTD |
PMID:14565775 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
flavanone results in increased expression of BAX protein |
CTD |
PMID:22056764 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone results in decreased activity of CASP3 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:22056764 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:22056764 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
flavanone results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:22056764 |
|
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
flavanone results in increased expression of CDKN1A protein |
CTD |
PMID:22056764 |
|
NCBI chr20:7,150,820...7,161,373
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
flavanone results in increased expression of CDKN1B protein |
CTD |
PMID:22056764 |
|
NCBI chr 4:169,491,273...169,496,500
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
flavanone affects the localization of CYCS protein |
CTD |
PMID:22056764 |
|
NCBI chr 4:80,982,667...80,984,767
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression decreases activity |
ISO |
flavanone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] flavanone results in increased expression of CYP1A1 mRNA flavanone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] flavanone results in decreased activity of CYP1A1 protein |
CTD |
PMID:17090139 PMID:20930378 PMID:21053930 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
flavanone results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
flavanone binds to and results in decreased activity of CYP1B1 protein flavanone analog results in increased expression of CYP1B1 mRNA |
CTD |
PMID:21053930 PMID:31621310 |
|
NCBI chr 6:21,093,927...21,103,091
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] flavanone results in decreased activity of CYP3A4 protein |
CTD |
PMID:21053930 |
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
flavanone results in increased expression of FAS mRNA |
CTD |
PMID:22056764 |
|
NCBI chr 1:241,212,155...241,245,774
|
|
G |
Faslg |
Fas ligand |
increases expression |
ISO |
flavanone results in increased expression of FASLG mRNA |
CTD |
PMID:22056764 |
|
NCBI chr13:76,680,885...76,706,042
|
|
G |
Maoa |
monoamine oxidase A |
decreases activity |
ISO |
flavanone results in decreased activity of MAOA protein |
CTD |
PMID:23009399 |
|
NCBI chr X:8,615,239...8,681,372
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
flavanone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
|
NCBI chr13:86,165,327...86,170,362
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
flavanone results in increased cleavage of PARP1 protein |
CTD |
PMID:22056764 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
ISO |
flavanone results in increased expression of PPARG protein |
CTD |
PMID:22056764 |
|
NCBI chr 4:150,095,743...150,221,104
|
|
G |
Pten |
phosphatase and tensin homolog |
increases expression |
ISO |
flavanone results in increased expression of PTEN protein |
CTD |
PMID:22056764 |
|
NCBI chr 1:240,043,707...240,110,330
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
flavanone results in decreased phosphorylation of RB1 protein |
CTD |
PMID:22056764 |
|
NCBI chr15:54,780,858...54,911,989
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
flavanone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
flavanone results in increased expression of and results in increased phosphorylation of TP53 protein |
CTD |
PMID:22056764 |
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
flavanone analog results in increased expression of UGT1A1 mRNA |
CTD |
PMID:31621310 |
|
NCBI chr 9:96,249,143...96,256,264
|
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
ISO |
kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter] |
CTD |
PMID:24997323 |
|
NCBI chr 3:161,713,777...161,764,844
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
kurarinol results in increased activity of CASP3 protein STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein] |
CTD |
PMID:24997323 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
kurarinol results in decreased expression of CCND1 protein |
CTD |
PMID:24997323 |
|
NCBI chr 1:209,518,288...209,527,986
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein |
CTD |
PMID:24997323 |
|
NCBI chr 2:185,884,840...185,912,532
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation |
ISO |
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein] kurarinol results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:24997323 |
|
NCBI chr10:86,311,528...86,363,513
|
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA] liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:67,503,077...67,504,875
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression |
ISO |
liquiritigenin results in increased expression of CXCL12 mRNA |
CTD |
PMID:28396216 |
|
NCBI chr 4:152,060,781...152,073,628
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
liquiritigenin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Esr1 |
estrogen receptor 1 |
increases activity |
ISO |
liquiritigenin results in increased activity of ESR1 protein |
CTD |
PMID:28396216 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Esr2 |
estrogen receptor 2 |
increases activity |
ISO |
liquiritigenin results in increased activity of ESR2 protein |
CTD |
PMID:25106122 |
|
NCBI chr 6:100,589,553...100,645,240
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] liquiritigenin results in increased expression of GCLC protein |
CTD |
PMID:29908794 |
|
NCBI chr 8:87,510,251...87,548,896
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
EXP |
liquiritigenin results in increased expression of GCLM protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 2:213,032,135...213,052,192
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] |
CTD |
PMID:31589899 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] |
CTD |
PMID:29908794 |
|
NCBI chr16:65,185,574...65,228,742
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 9:64,073,610...64,084,332
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA] liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] |
CTD |
PMID:29908794 PMID:31589899 |
|
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] |
CTD |
PMID:31589899 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases response to substance multiple interactions |
ISO EXP |
NFE2L2 gene mutant form results in decreased susceptibility to liquiritigenin liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA] liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO EXP |
liquiritigenin results in increased expression of NQO1 protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA] |
CTD |
PMID:26473469 PMID:29908794 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein] |
CTD |
PMID:31589899 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] |
CTD |
PMID:29908794 |
|
NCBI chr10:35,026,598...35,037,750
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 5:85,161,247...85,174,882
|
|
G |
Trpm3 |
transient receptor potential cation channel, subfamily M, member 3 |
decreases activity |
ISO |
liquiritigenin results in decreased activity of TRPM3 protein |
CTD |
PMID:25361167 |
|
NCBI chr 1:219,673,200...220,557,610
|
|
G |
Tsc22d3 |
TSC22 domain family, member 3 |
multiple interactions |
ISO |
liquiritigenin inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] |
CTD |
PMID:23183181 |
|
NCBI chr X:109,006,410...109,066,389
|
|
G |
Txn2 |
thioredoxin 2 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr 7:111,377,338...111,390,940
|
|
G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr11:82,519,996...82,568,156
|
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO |
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA |
CTD |
PMID:36008890 |
|
NCBI chr 3:74,424,620...74,520,646
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in decreased expression of ABCC2 mRNA |
CTD |
PMID:36008890 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 mRNA |
CTD |
PMID:36008890 |
|
NCBI chr10:79,793,571...79,839,528
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 mRNA |
CTD |
PMID:36008890 |
|
NCBI chr15:101,948,387...102,182,912
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA] liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:67,503,077...67,504,875
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
[brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein |
CTD |
PMID:21800547 |
|
NCBI chr 1:205,269,967...205,280,365
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
EXP |
liquiritin results in increased expression of GCLC protein liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 8:87,510,251...87,548,896
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA] liquiritin results in increased expression of GCLM protein |
CTD |
PMID:29908794 |
|
NCBI chr 2:213,032,135...213,052,192
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] |
CTD |
PMID:31589899 PMID:36008890 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] |
CTD |
PMID:29908794 |
|
NCBI chr16:65,185,574...65,228,742
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 mRNA; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 protein] |
CTD |
PMID:29908794 PMID:36008890 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO EXP |
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 9:64,073,610...64,084,332
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein] |
CTD |
PMID:36008890 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA] liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] |
CTD |
PMID:36008890 |
|
NCBI chr 8:19,768,375...19,777,862
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] |
CTD |
PMID:29908794 PMID:31589899 |
|
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] |
CTD |
PMID:31589899 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases response to substance multiple interactions |
ISO EXP |
NFE2L2 gene mutant form results in decreased susceptibility to liquiritin liquiritin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NFE2L2 protein] liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:29908794 PMID:36008890 |
|
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA] liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA] [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 mRNA |
CTD |
PMID:29908794 PMID:36008890 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein] |
CTD |
PMID:36008890 |
|
NCBI chr 7:25,733,471...25,829,440
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein] liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] |
CTD |
PMID:31589899 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein] |
CTD |
PMID:36008890 |
|
NCBI chr20:25,305,953...25,328,000
|
|
G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
ISO |
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] |
CTD |
PMID:36008890 |
|
NCBI chr 6:100,613,045...100,626,670
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] |
CTD |
PMID:29908794 |
|
NCBI chr10:35,026,598...35,037,750
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 5:85,161,247...85,174,882
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein] |
CTD |
PMID:36008890 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Txn2 |
thioredoxin 2 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr 7:111,377,338...111,390,940
|
|
G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr11:82,519,996...82,568,156
|
|
|
G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
ISO |
pinostrobin results in increased expression of AARS1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr19:38,999,130...39,021,152
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases activity decreases response to substance |
ISO |
[pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine] ABCB1 protein results in decreased susceptibility to pinostrobin |
CTD |
PMID:37259354 |
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Acvr1 |
activin A receptor type 1 |
increases expression |
ISO |
pinostrobin results in increased expression of ACVR1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:63,387,378...63,506,980
|
|
G |
Ahctf1 |
AT hook containing transcription factor 1 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of AHCTF1 protein |
CTD |
PMID:37164308 |
|
NCBI chr13:91,481,936...91,536,391
|
|
G |
Aifm3 |
AIF family member 3 |
increases expression |
ISO |
pinostrobin results in increased expression of AIFM3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr11:83,504,859...83,523,630
|
|
G |
Arel1 |
apoptosis resistant E3 ubiquitin protein ligase 1 |
increases expression |
ISO |
pinostrobin results in increased expression of AREL1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 6:104,560,556...104,617,712
|
|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
pinostrobin results in increased expression of ASNS mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:36,752,061...36,769,970
|
|
G |
Atm |
ATM serine/threonine kinase |
increases expression |
ISO |
pinostrobin results in increased expression of ATM mRNA; pinostrobin results in increased expression of ATM protein |
CTD |
PMID:37208425 |
|
NCBI chr 8:62,724,939...62,829,040
|
|
G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
ISO |
pinostrobin results in increased expression of ATP5F1A mRNA |
CTD |
PMID:37777166 |
|
NCBI chr18:73,567,537...73,575,473
|
|
G |
Axl |
Axl receptor tyrosine kinase |
increases expression |
ISO |
pinostrobin results in increased expression of AXL mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:90,392,864...90,424,123
|
|
G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
pinostrobin results in increased expression of BAD mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:213,562,719...213,572,034
|
|
G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
pinostrobin results in increased expression of BAK1 mRNA |
CTD |
PMID:37164308 |
|
NCBI chr20:5,102,334...5,111,615
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
pinostrobin results in increased expression of BAX mRNA; pinostrobin results in increased expression of BAX protein pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA] |
CTD |
PMID:37208425 PMID:37342552 PMID:37777166 PMID:38078205 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
pinostrobin results in increased expression of BBC3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:86,141,450...86,150,666
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
pinostrobin results in decreased expression of BCL2 protein pinostrobin inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA] |
CTD |
PMID:37342552 PMID:37777166 PMID:38078205 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
pinostrobin results in increased expression of BCL2L11 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:135,820,042...135,857,330
|
|
G |
Bcl2l2 |
Bcl2-like 2 |
decreases expression |
ISO |
pinostrobin results in decreased expression of BCL2L2 mRNA |
CTD |
PMID:37164308 |
|
NCBI chr15:28,346,449...28,361,627
|
|
G |
Bmf |
Bcl2 modifying factor |
increases expression |
ISO |
pinostrobin results in increased expression of BMF mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:125,953,466...125,974,087
|
|
G |
Calhm2 |
calcium homeostasis modulator family member 2 |
increases expression |
ISO |
pinostrobin results in increased expression of CALHM2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:246,022,324...246,028,050
|
|
G |
Capn3 |
calpain 3 |
increases expression |
ISO |
pinostrobin results in increased expression of CAPN3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:127,860,002...127,913,677
|
|
G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
ISO EXP |
pinostrobin results in increased expression of CASP3 mRNA; pinostrobin results in increased expression of CASP3 protein [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein pinostrobin inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein] |
CTD |
PMID:37164308 PMID:37208425 PMID:37342552 PMID:37866152 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp8 |
caspase 8 |
increases expression |
ISO |
pinostrobin results in increased expression of CASP8 mRNA |
CTD |
PMID:37208425 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Casp9 |
caspase 9 |
increases expression |
ISO |
pinostrobin results in increased expression of CASP9 mRNA |
CTD |
PMID:37208425 |
|
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein] |
CTD |
PMID:37342552 PMID:37866152 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Cbs |
cystathionine beta synthase |
increases expression |
ISO |
pinostrobin results in increased expression of CBS mRNA |
CTD |
PMID:37777166 |
|
NCBI chr20:9,708,089...9,732,623
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
pinostrobin results in decreased expression of CCNE1 protein |
CTD |
PMID:37777166 |
|
NCBI chr 1:99,918,672...99,927,986
|
|
G |
Cd14 |
CD14 molecule |
increases expression |
ISO |
pinostrobin results in increased expression of CD14 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr18:28,609,558...28,611,409
|
|
G |
Cd70 |
Cd70 molecule |
increases expression |
ISO |
pinostrobin results in increased expression of CD70 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 9:2,006,563...2,009,715
|
|
G |
Cdc40 |
cell division cycle 40 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of CDC40 protein |
CTD |
PMID:37164308 |
|
NCBI chr20:44,273,080...44,325,605
|
|
G |
Cdh1 |
cadherin 1 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of CDH1 protein |
CTD |
PMID:37164308 |
|
NCBI chr19:51,402,178...51,471,572
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
pinostrobin results in increased expression of CDKN1A mRNA; pinostrobin results in increased expression of CDKN1A protein |
CTD |
PMID:37777166 |
|
NCBI chr20:7,150,820...7,161,373
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
pinostrobin results in increased expression of CDKN1B protein |
CTD |
PMID:37777166 |
|
NCBI chr 4:169,491,273...169,496,500
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression |
ISO |
pinostrobin results in increased expression of CEBPB mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:176,817,005...176,818,436
|
|
G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression |
ISO |
pinostrobin results in increased expression of CHAC1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:126,796,131...126,799,352
|
|
G |
Cideb |
cell death-inducing DFFA-like effector b |
increases expression |
ISO |
pinostrobin results in increased expression of CIDEB mRNA |
CTD |
PMID:37777166 |
|
NCBI chr15:29,252,208...29,256,482
|
|
G |
Cldn7 |
claudin 7 |
increases expression |
ISO |
pinostrobin results in increased expression of CLDN7 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:55,188,670...55,190,871
|
|
G |
Creld2 |
cysteine-rich with EGF-like domains 2 |
decreases expression |
ISO |
pinostrobin results in decreased expression of CRELD2 protein |
CTD |
PMID:37164308 |
|
NCBI chr 7:119,909,626...119,916,556
|
|
G |
Cth |
cystathionine gamma-lyase |
increases expression |
ISO |
pinostrobin results in increased expression of CTH mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 2:249,634,731...249,661,066
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression |
ISO |
pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein] pinostrobin results in decreased expression of CTNNB1 mRNA; pinostrobin results in decreased expression of CTNNB1 protein |
CTD |
PMID:37164308 |
|
NCBI chr 8:129,517,576...129,544,661
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
ISO |
pinostrobin results in increased expression of CXCR4 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr13:42,630,383...42,634,288
|
|
G |
Dcps |
decapping enzyme, scavenger |
increases expression |
ISO |
pinostrobin results in increased expression of DCPS mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 8:41,729,507...41,782,222
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
pinostrobin results in increased expression of DDIT3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:65,001,695...65,006,517
|
|
G |
Ddit4 |
DNA-damage-inducible transcript 4 |
increases expression |
ISO |
pinostrobin results in increased expression of DDIT4 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr20:28,434,938...28,437,037
|
|
G |
Dnase1 |
deoxyribonuclease 1 |
increases expression |
ISO |
pinostrobin results in increased expression of DNASE1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:11,498,930...11,505,151
|
|
G |
Dnase2 |
deoxyribonuclease 2, lysosomal |
increases expression |
ISO |
pinostrobin results in increased expression of DNASE2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr19:23,244,656...23,247,376
|
|
G |
Doc2b |
double C2 domain beta |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of DOC2B protein |
CTD |
PMID:37164308 |
|
NCBI chr10:60,628,029...60,653,267
|
|
G |
Elmo1 |
engulfment and cell motility 1 |
increases expression |
ISO |
pinostrobin results in increased expression of ELMO1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr17:44,286,495...44,822,668
|
|
G |
Erc1 |
ELKS/RAB6-interacting/CAST family member 1 |
increases expression |
ISO |
pinostrobin results in increased expression of ERC1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:152,763,664...153,055,724
|
|
G |
Ercc2 |
ERCC excision repair 2, TFIIH core complex helicase subunit |
increases expression |
ISO |
pinostrobin results in increased expression of ERCC2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:88,161,342...88,175,102
|
|
G |
Etv6 |
ETS variant transcription factor 6 |
increases expression |
ISO |
pinostrobin results in increased expression of ETV6 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:166,849,031...167,085,211
|
|
G |
Fank1 |
fibronectin type III and ankyrin repeat domains 1 |
increases expression |
ISO |
pinostrobin results in increased expression of FANK1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:188,577,512...188,685,501
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
pinostrobin results in increased expression of FAS mRNA |
CTD |
PMID:37208425 |
|
NCBI chr 1:241,212,155...241,245,774
|
|
G |
Fbh1 |
F-box DNA helicase 1 |
increases expression |
ISO |
pinostrobin results in increased expression of FBH1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr17:66,749,506...66,787,590
|
|
G |
Fcmr |
Fc mu receptor |
increases expression |
ISO |
pinostrobin results in increased expression of FCMR mRNA |
CTD |
PMID:37777166 |
|
NCBI chr13:42,337,363...42,351,706
|
|
G |
Fer1l4 |
fer-1-like family member 4 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of FER1L4 protein |
CTD |
PMID:37164308 |
|
NCBI chr 3:144,536,099...144,571,634
|
|
G |
Flcn |
folliculin |
increases expression |
ISO |
pinostrobin results in increased expression of FLCN mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:45,088,164...45,107,581
|
|
G |
Fmo5 |
flavin containing dimethylaniline monoxygenase 5 |
decreases phosphorylation |
ISO |
pinostrobin results in decreased phosphorylation of FMO5 protein |
CTD |
PMID:37164308 |
|
NCBI chr 2:185,197,184...185,249,699
|
|
G |
Foxa1 |
forkhead box A1 |
increases expression |
ISO |
pinostrobin results in increased expression of FOXA1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 6:75,099,907...75,136,534
|
|
G |
Foxo3 |
forkhead box O3 |
multiple interactions increases expression |
ISO |
pinostrobin results in increased expression of and affects the localization of FOXO3 protein pinostrobin results in increased expression of FOXO3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr20:47,251,968...47,348,254
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Methotrexate results in increased expression of FSHB protein] |
CTD |
PMID:37866152 |
|
NCBI chr 3:114,003,262...114,007,072
|
|
G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
increases expression |
ISO |
pinostrobin results in increased expression of FYN mRNA |
CTD |
PMID:37777166 |
|
NCBI chr20:44,322,635...44,514,498
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
pinostrobin results in increased expression of GADD45A mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:97,484,497...97,486,799
|
|
G |
Glb1 |
galactosidase, beta 1 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of GLB1 protein |
CTD |
PMID:37164308 |
|
NCBI chr 8:122,963,718...123,036,326
|
|
G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
pinostrobin results in increased expression of GRINA mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:107,962,194...107,965,372
|
|
G |
Grn |
granulin precursor |
increases expression |
ISO |
pinostrobin results in increased expression of GRN mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:87,387,672...87,393,777
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in decreased activity of GSR protein] |
CTD |
PMID:37342552 |
|
NCBI chr16:65,185,574...65,228,742
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein] |
CTD |
PMID:37342552 |
|
NCBI chr10:31,118,667...31,151,730
|
|
G |
Hip1 |
huntingtin interacting protein 1 |
increases expression |
ISO |
pinostrobin results in increased expression of HIP1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr12:26,769,868...26,904,367
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
pinostrobin results in increased expression of HMOX1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hsh2d |
hematopoietic SH2 domain containing |
increases expression |
ISO |
pinostrobin results in increased expression of HSH2D mRNA |
CTD |
PMID:37777166 |
|
NCBI chr16:17,630,519...17,649,932
|
|
G |
Id3 |
inhibitor of DNA binding 3 |
increases expression |
ISO |
pinostrobin results in increased expression of ID3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 5:153,656,253...153,657,860
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of IL10 protein] |
CTD |
PMID:38078205 |
|
NCBI chr13:45,024,921...45,029,586
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein] |
CTD |
PMID:37342552 PMID:37866152 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL6 protein] |
CTD |
PMID:37342552 PMID:37866152 PMID:38078205 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Ing4 |
inhibitor of growth family, member 4 |
increases expression |
ISO |
pinostrobin results in increased expression of ING4 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:159,528,183...159,536,762
|
|
G |
Inhba |
inhibin subunit beta A |
increases expression |
ISO |
pinostrobin results in increased expression of INHBA mRNA |
CTD |
PMID:37777166 |
|
NCBI chr17:53,787,159...53,810,942
|
|
G |
Ino80 |
INO80 complex ATPase subunit |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of INO80 protein |
CTD |
PMID:37164308 |
|
NCBI chr 3:126,822,280...126,919,532
|
|
G |
Irf7 |
interferon regulatory factor 7 |
increases expression |
ISO |
pinostrobin results in increased expression of IRF7 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:205,796,956...205,800,543
|
|
G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
pinostrobin results in increased expression of ITGAM mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:192,089,496...192,139,947
|
|
G |
Itpk1 |
inositol-tetrakisphosphate 1-kinase |
increases expression |
ISO |
pinostrobin results in increased expression of ITPK1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 6:127,475,589...127,609,320
|
|
G |
Kdm2b |
lysine demethylase 2B |
increases expression |
ISO |
pinostrobin results in increased expression of KDM2B mRNA |
CTD |
PMID:37777166 |
|
NCBI chr12:39,224,422...39,362,126
|
|
G |
Lcn2 |
lipocalin 2 |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in increased expression of LCN2 protein] |
CTD |
PMID:37342552 |
|
NCBI chr 3:36,078,432...36,081,851
|
|
G |
Lgals2 |
galectin 2 |
increases expression |
ISO |
pinostrobin results in increased expression of LGALS2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:112,283,630...112,290,228
|
|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Methotrexate results in increased expression of LHB protein] |
CTD |
PMID:37866152 |
|
NCBI chr 1:105,037,457...105,038,446
|
|
G |
Madd |
MAP-kinase activating death domain |
increases expression |
ISO |
pinostrobin results in increased expression of MADD mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:77,114,330...77,157,865
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
pinostrobin results in decreased expression of MCL1 mRNA |
CTD |
PMID:37164308 |
|
NCBI chr 2:185,884,840...185,912,532
|
|
G |
Mef2a |
myocyte enhancer factor 2a |
increases expression |
ISO |
pinostrobin results in increased expression of MEF2A mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:120,847,874...120,982,488
|
|
G |
Mef2d |
myocyte enhancer factor 2D |
increases expression |
ISO |
pinostrobin results in increased expression of MEF2D mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 2:173,606,054...173,635,620
|
|
G |
Mir410 |
microRNA 410 |
decreases expression multiple interactions |
ISO |
pinostrobin results in decreased expression of MIR410 mRNA [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein] |
CTD |
PMID:37164308 |
|
NCBI chr 6:128,758,358...128,758,433
|
|
G |
Mrpl1 |
mitochondrial ribosomal protein L1 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of MRPL1 protein |
CTD |
PMID:37164308 |
|
NCBI chr14:13,300,522...13,359,654
|
|
G |
Mt3 |
metallothionein 3 |
increases expression |
ISO |
pinostrobin results in increased expression of MT3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr19:10,848,754...10,850,158
|
|
G |
Mutyh |
mutY DNA glycosylase |
increases expression |
ISO |
pinostrobin results in increased expression of MUTYH mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 5:130,274,034...130,286,149
|
|
G |
Naip6 |
NLR family, apoptosis inhibitory protein 6 |
increases expression |
ISO |
pinostrobin results in increased expression of NAIP mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 2:31,507,423...31,559,098
|
|
G |
Ninj1 |
ninjurin 1 |
increases expression |
ISO |
pinostrobin results in increased expression of NINJ1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr17:15,659,208...15,668,115
|
|
G |
Nisch |
nischarin |
increases expression |
ISO |
pinostrobin results in increased expression of NISCH mRNA |
CTD |
PMID:37777166 |
|
NCBI chr16:6,370,809...6,407,104
|
|
G |
Nlrp1a |
NLR family, pyrin domain containing 1A |
increases expression |
ISO |
pinostrobin results in increased expression of NLRP1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:55,778,560...55,833,639
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of NOS2 protein] |
CTD |
PMID:37342552 PMID:37866152 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nos3 |
nitric oxide synthase 3 |
increases expression |
ISO |
pinostrobin results in increased expression of NOS3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:11,686,088...11,706,604
|
|
G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression |
ISO |
pinostrobin results in increased expression of NR4A1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:132,368,399...132,389,300
|
|
G |
Ntsr1 |
neurotensin receptor 1 |
increases expression |
ISO |
pinostrobin results in increased expression of NTSR1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:187,983,778...188,033,934
|
|
G |
P2rx1 |
purinergic receptor P2X 1 |
increases expression |
ISO |
pinostrobin results in increased expression of P2RX1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:57,618,586...57,633,648
|
|
G |
P2rx7 |
purinergic receptor P2X 7 |
increases expression |
ISO |
pinostrobin results in increased expression of P2RX7 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr12:39,550,531...39,594,984
|
|
G |
Pde1b |
phosphodiesterase 1B |
increases expression |
ISO |
pinostrobin results in increased expression of PDE1B mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:134,627,378...134,654,581
|
|
G |
Peli3 |
pellino E3 ubiquitin protein ligase family member 3 |
increases expression |
ISO |
pinostrobin results in increased expression of PELI3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:202,230,034...202,242,900
|
|
G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
increases expression |
ISO |
pinostrobin results in increased expression of PHLDA3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr13:47,193,250...47,196,335
|
|
G |
Pim2 |
Pim-2 proto-oncogene, serine/threonine kinase |
increases expression |
ISO |
pinostrobin results in increased expression of PIM2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr X:17,289,509...17,294,778
|
|
G |
Plaur |
plasminogen activator, urokinase receptor |
increases expression |
ISO |
pinostrobin results in increased expression of PLAUR mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:89,181,363...89,196,308
|
|
G |
Pld1 |
phospholipase D1 |
increases expression |
ISO |
pinostrobin results in increased expression of PLD1 protein |
CTD |
PMID:37164308 |
|
NCBI chr 2:112,777,820...112,975,857
|
|
G |
Plec |
plectin |
decreases expression |
ISO |
pinostrobin results in decreased expression of PLEC protein |
CTD |
PMID:37164308 |
|
NCBI chr 7:109,768,447...109,829,798
|
|
G |
Plxnd1 |
plexin D1 |
increases expression |
ISO |
pinostrobin results in increased expression of PLXND1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:149,002,786...149,043,097
|
|
G |
Pmp22 |
peripheral myelin protein 22 |
increases expression |
ISO |
pinostrobin results in increased expression of PMP22 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:48,294,932...48,324,941
|
|
G |
Pou3f3 |
POU class 3 homeobox 3 |
increases expression |
ISO |
pinostrobin results in increased expression of POU3F3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 9:44,945,872...44,948,998
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression |
ISO |
pinostrobin results in increased expression of PPARA mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:118,712,261...118,780,723
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein] |
CTD |
PMID:37342552 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Ptk2b |
protein tyrosine kinase 2 beta |
increases expression |
ISO |
pinostrobin results in increased expression of PTK2B mRNA |
CTD |
PMID:37777166 |
|
NCBI chr15:44,536,275...44,656,754
|
|
G |
Qars1 |
glutaminyl-tRNA synthetase 1 |
increases expression |
ISO |
pinostrobin results in increased expression of QARS1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 8:109,207,705...109,215,738
|
|
G |
Ret |
ret proto-oncogene |
increases expression |
ISO |
pinostrobin results in increased expression of RET mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:152,998,344...153,040,556
|
|
G |
Rnf130 |
ring finger protein 130 |
increases expression |
ISO |
pinostrobin results in increased expression of RNF130 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:34,342,835...34,456,048
|
|
G |
Rnf216 |
ring finger protein 216 |
increases expression |
ISO |
pinostrobin results in increased expression of RNF216 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr12:11,454,752...11,576,305
|
|
G |
RT1-CE5 |
RT1 class I, locus CE5 |
increases expression |
ISO |
pinostrobin results in increased expression of HLA-F mRNA |
CTD |
PMID:37777166 |
|
NCBI chr20:3,403,418...3,479,476
|
|
G |
Rtkn |
rhotekin |
increases expression |
ISO |
pinostrobin results in increased expression of RTKN mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:115,640,813...115,657,952
|
|
G |
Scfd2 |
sec1 family domain containing 2 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of SCFD2 protein |
CTD |
PMID:37164308 |
|
NCBI chr14:33,683,348...34,008,232
|
|
G |
Scn2a |
sodium voltage-gated channel alpha subunit 2 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of SCN2A protein |
CTD |
PMID:37164308 |
|
NCBI chr 3:70,710,862...70,845,569
|
|
G |
Scx |
scleraxis bHLH transcription factor |
increases expression |
ISO |
pinostrobin results in increased expression of SCX mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:108,176,608...108,178,626
|
|
G |
Selenos |
selenoprotein S |
increases expression |
ISO |
pinostrobin results in increased expression of SELENOS mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:119,659,779...119,669,546
|
|
G |
Serpinf1 |
serpin family F member 1 |
increases expression |
ISO |
pinostrobin results in increased expression of SERPINF1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:60,250,198...60,262,593
|
|
G |
Sfrp5 |
secreted frizzled-related protein 5 |
multiple interactions increases phosphorylation increases expression |
ISO |
pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein] pinostrobin results in increased phosphorylation of SFRP5 protein pinostrobin results in increased expression of SFRP5 mRNA; pinostrobin results in increased expression of SFRP5 protein |
CTD |
PMID:37164308 |
|
NCBI chr 1:241,006,762...241,011,224
|
|
G |
Sharpin |
SHANK-associated RH domain interactor |
increases expression |
ISO |
pinostrobin results in increased expression of SHARPIN mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 7:109,951,336...109,955,552
|
|
G |
Shisa5 |
shisa family member 5 |
increases expression |
ISO |
pinostrobin results in increased expression of SHISA5 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 8:118,569,975...118,584,880
|
|
G |
Slc10a5 |
solute carrier family 10, member 5 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of SLC10A5 protein |
CTD |
PMID:37164308 |
|
NCBI chr 2:91,457,540...91,458,844
|
|
G |
Slc25a5-ps11 |
solute carrier family 25 member 5, pseudogene 11 |
increases expression |
ISO |
pinostrobin results in increased expression of SLC25A6 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr18:68,571,222...68,572,461
|
|
G |
Slc46a2 |
solute carrier family 46, member 2 |
increases expression |
ISO |
pinostrobin results in increased expression of SLC46A2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 5:74,800,226...74,808,128
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
pinostrobin results in increased expression of SLC7A11 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 2:136,532,912...136,668,560
|
|
G |
Slco5a1 |
solute carrier organic anion transporter family, member 5A1 |
increases expression |
ISO |
pinostrobin results in increased expression of SLCO5A1 protein |
CTD |
PMID:37164308 |
|
NCBI chr 5:6,228,938...6,358,124
|
|
G |
Smad3 |
SMAD family member 3 |
increases expression |
ISO |
pinostrobin results in increased expression of SMAD3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 8:64,126,829...64,236,960
|
|
G |
Smim7 |
small integral membrane protein 7 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of SMIM7 protein |
CTD |
PMID:37164308 |
|
NCBI chr16:17,274,417...17,278,336
|
|
G |
Stap2 |
signal transducing adaptor family member 2 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of STAP2 protein |
CTD |
PMID:37164308 |
|
NCBI chr 9:828,369...838,648
|
|
G |
Star |
steroidogenic acute regulatory protein |
increases expression |
ISO |
pinostrobin results in increased expression of STAR mRNA |
CTD |
PMID:37777166 |
|
NCBI chr16:72,969,824...72,974,447
|
|
G |
Stxbp1 |
syntaxin binding protein 1 |
increases expression |
ISO |
pinostrobin results in increased expression of STXBP1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:16,076,725...16,138,431
|
|
G |
Sycp2l |
synaptonemal complex protein 2-like |
increases expression |
ISO |
pinostrobin results in increased expression of SYCP2L mRNA |
CTD |
PMID:37777166 |
|
NCBI chr17:23,589,217...23,645,273
|
|
G |
Taf10 |
TATA-box binding protein associated factor 10 |
increases expression |
ISO |
pinostrobin results in increased expression of TAF10 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:160,095,108...160,096,401
|
|
G |
Tcirg1 |
T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 |
increases expression |
ISO |
pinostrobin results in increased expression of TCIRG1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:210,556,270...210,568,021
|
|
G |
Tmem109 |
transmembrane protein 109 |
increases expression |
ISO |
pinostrobin results in increased expression of TMEM109 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 1:207,519,628...207,530,245
|
|
G |
Tmem39a |
transmembrane protein 39a |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of TMEM39A protein |
CTD |
PMID:37164308 |
|
NCBI chr11:62,160,631...62,189,964
|
|
G |
Tmem79 |
transmembrane protein 79 |
increases expression |
ISO |
pinostrobin results in increased expression of TMEM79 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 2:173,798,267...173,803,151
|
|
G |
Tmprss4 |
transmembrane serine protease 4 |
increases phosphorylation |
ISO |
pinostrobin results in increased phosphorylation of TMPRSS4 protein |
CTD |
PMID:37164308 |
|
NCBI chr 8:45,475,819...45,508,409
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNF protein] |
CTD |
PMID:37342552 PMID:37866152 PMID:38078205 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tnfrsf11a |
TNF receptor superfamily member 11A |
multiple interactions |
EXP |
pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNFRSF11A protein] |
CTD |
PMID:37866152 |
|
NCBI chr13:22,442,930...22,501,257
|
|
G |
Tnfsf14 |
TNF superfamily member 14 |
increases expression |
ISO |
pinostrobin results in increased expression of TNFSF14 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 9:2,155,270...2,160,100
|
|
G |
Tnfsf9 |
TNF superfamily member 9 |
increases expression |
ISO |
pinostrobin results in increased expression of TNFSF9 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 9:2,031,011...2,033,345
|
|
G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
pinostrobin results in increased expression of TP53 mRNA |
CTD |
PMID:37208425 |
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Trap1 |
TNF receptor-associated protein 1 |
increases expression |
ISO |
pinostrobin results in increased expression of TRAP1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:11,971,259...12,005,306
|
|
G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO |
pinostrobin results in increased expression of TRIB3 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 3:161,269,939...161,275,533
|
|
G |
Trpm2 |
transient receptor potential cation channel, subfamily M, member 2 |
increases expression |
ISO |
pinostrobin results in increased expression of TRPM2 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr20:10,703,568...10,753,189
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
increases expression |
ISO |
pinostrobin results in increased expression of TRPV1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr10:58,349,936...58,375,021
|
|
G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
pinostrobin results in increased expression of VEGFA mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
pinostrobin results in increased expression of XBP1 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr14:84,604,623...84,609,707
|
|
G |
Zfp746 |
zinc finger protein 746 |
increases expression |
ISO |
pinostrobin results in increased expression of ZNF746 mRNA |
CTD |
PMID:37777166 |
|
NCBI chr 4:77,055,008...77,078,968
|
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
sophoranone results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
sophoranone results in decreased activity of CYP2D6 protein |
CTD |
PMID:29753067 |
|
NCBI chr 7:115,762,662...115,771,832
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
sophoranone results in decreased activity of CYP3A4 protein |
CTD |
PMID:29753067 |
|
NCBI chr12:14,321,771...14,343,886
|
|