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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:minocycline
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Accession:CHEBI:50694 term browser browse the term
Definition:A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Synonyms:related_synonym: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE;   7-Dimethylamino-6-demethyl-6-deoxytetracycline;   Formula=C23H27N3O7;   InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1;   InChIKey=DYKFCLLONBREIL-KVUCHLLUSA-N;   SMILES=[H][C@@]12Cc3c(ccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C;   minociclina;   minociclinum;   minomycin
 alt_id: CHEBI:44053;   CHEBI:6939
 xref: Beilstein:3077644;   CAS:10118-90-8;   Chemspider:16735907;   DrugBank:DB01017;   Drug_Central:1813;   HMDB:HMDB0015152;   KEGG:C07225;   KEGG:D05045;   KNApSAcK:C00018686;   LIPID_MAPS_instance:LMPK07000002
 xref_mesh: MESH:D008911
 xref: PDBeChem:MIY;   PMID:22330257;   PMID:28709717;   PMID:31630007;   PMID:31719236;   PMID:31733348;   PMID:33568043;   PMID:34232283;   PMID:34636517;   Patent:US3226436;   Patent:WO2008104734;   Reaxys:3077644
 cyclic_relationship: is_conjugate_acid_of CHEBI:71337;   is_tautomer_of CHEBI:77906


show annotations for term's descendants           Sort by:
minocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
decreases expression		 ISO Minocycline affects the reaction [GPX1 protein affects the expression of AIF1 protein]; Minocycline inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]
Minocycline results in decreased expression of AIF1 protein		 CTD PMID:32916201 PMID:36682417 PMID:37394652 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
decreases secretion		 EXP
ISO		 Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
Minocycline results in decreased secretion of AIFM1 protein		 CTD PMID:12930891 PMID:16469440 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP		 Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:17406652 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein] CTD PMID:21050491 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein] CTD PMID:22245251 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5F1A protein] CTD PMID:23562983 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of ATP5PD protein] CTD PMID:21561882 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Minocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA] CTD PMID:18583042 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein CTD PMID:15004018 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; Minocycline inhibits the reaction [Sodium Azide affects the localization of BAX protein]
Minocycline results in decreased expression of BAX protein
Minocycline inhibits the reaction [Rotenone results in increased expression of BAX protein]		 CTD PMID:15004018 PMID:15172883 PMID:33402167 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein
[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein; [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Sodium Azide inhibits the reaction [Minocycline results in increased expression of BCL2 protein]
Minocycline results in increased expression of BCL2 mRNA; Minocycline results in increased expression of BCL2 protein		 CTD PMID:15004018 PMID:19807907 PMID:20606027 PMID:20711699 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Minocycline inhibits the reaction [Rotenone results in decreased expression of BCL2L1 protein] CTD PMID:33402167 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO
EXP		 Minocycline results in decreased activity of and results in decreased cleavage of BID protein
[Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]		 CTD PMID:12930891 PMID:15004018 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp1 caspase 1 multiple interactions
decreases activity
decreases expression		 EXP
ISO		 Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]
Minocycline results in decreased activity of CASP1 protein
Minocycline results in decreased expression of CASP1 mRNA; Minocycline results in decreased expression of CASP1 protein		 CTD PMID:12930891 PMID:14998631 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions
decreases expression		 EXP Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein]
Minocycline results in decreased expression of CASP12 mRNA; Minocycline results in decreased expression of CASP12 protein		 CTD PMID:14998631 PMID:17406652 PMID:22245251 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 Minocycline results in decreased activity of CASP3 protein
Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]; Minocycline results in decreased activity of and results in decreased cleavage of CASP3 protein
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Sodium Azide results in increased activity of CASP3 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP3 protein
Minocycline results in decreased expression of CASP3 mRNA
Minocycline pretreatment inhibits the reaction [azide increases activity of Casp3 protein in kidney proximal tubular epithelial cells]		 CTD
RGD		 PMID:12930891 PMID:14588118 PMID:14998631 PMID:15004018 PMID:15304547 More... RGD:1581919 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 decreases expression
multiple interactions		 EXP Minocycline results in decreased expression of CASP7 mRNA
Minocycline results in decreased expression of and results in decreased activity of CASP7 protein		 CTD PMID:14998631 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression		 EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP8 protein
Minocycline results in decreased expression of CASP8 mRNA		 CTD PMID:12930891 PMID:14998631 PMID:35939230 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 Minocycline results in decreased activity of CASP9 protein
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP9 protein
Minocycline results in decreased expression of CASP9 mRNA		 CTD PMID:12930891 PMID:14998631 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO Minocycline results in decreased expression of CCL2 protein
Minocycline inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]		 CTD PMID:20116850 PMID:24530660 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
multiple interactions		 ISO Minocycline results in decreased expression of CCL3 protein
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL3 protein]		 CTD PMID:20116850 PMID:35351628 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Minocycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression
multiple interactions		 ISO Minocycline results in decreased expression of CCL5 protein
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL5 protein]		 CTD PMID:20116850 PMID:35351628 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Minocycline affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD68 protein]; Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD68 mRNA] CTD PMID:35351628 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Minocycline results in increased expression of CDKN1B mRNA; Minocycline results in increased expression of CDKN1B protein CTD PMID:21719015 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cldn5 claudin 5 increases expression EXP minocycline increases expression of claudin-5 protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases secretion		 ISO
EXP		 Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Minocycline results in decreased secretion of CYCS protein
Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]		 CTD PMID:12930891 PMID:14998631 PMID:15172883 PMID:16469440 PMID:21424555 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of DDIT3 protein] CTD PMID:22245251 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases secretion
multiple interactions		 ISO
EXP		 Minocycline results in decreased secretion of DIABLO protein
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]; Minocycline results in decreased secretion of and results in decreased expression of DIABLO protein		 CTD PMID:12930891 PMID:14998631 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions ISO Minocycline inhibits the reaction [Rotenone results in decreased expression of DLG1 protein] CTD PMID:33402167 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Minocycline affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of DLG4 protein] CTD PMID:35351628 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression		 ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein CTD PMID:24292262 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein] CTD PMID:17406652 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Minocycline results in increased phosphorylation of EIF2AK3 protein CTD PMID:22245251 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation		 ISO
EXP		 Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
Minocycline results in increased phosphorylation of EIF2S1 protein		 CTD PMID:17406652 PMID:22245251 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eno1 enolase 1 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:23562983 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation EXP Minocycline results in increased phosphorylation of ERN1 protein CTD PMID:22245251 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions ISO Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:18835858 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Minocycline inhibits the reaction [Rotenone results in increased expression of GFAP protein] CTD PMID:33402167 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gjc2 gap junction protein, gamma 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of GJC2 protein modified form] CTD PMID:21561882 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Minocycline affects the reaction [GPX1 protein affects the expression of AIF1 protein]; Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein] CTD PMID:36682417 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA] CTD PMID:19660546 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP minocycline increases expression of glutathione S-transferase pi protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases degradation		 ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; Minocycline promotes the reaction [HIF1A protein binds to VHL protein]
Minocycline results in increased degradation of HIF1A protein		 CTD PMID:24292262 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hp haptoglobin increases expression EXP minocycline increases expression of zonulin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein] CTD PMID:22245251 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of HSPD1 protein] CTD PMID:21561882 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Htt huntingtin multiple interactions EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein] CTD PMID:12930891 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Minocycline results in decreased expression of ICAM1 protein CTD PMID:15172883 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]
[Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA		 CTD PMID:19285099 PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 ISO
EXP		 Minocycline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Minocycline results in increased expression of IL10 mRNA		 CTD PMID:14588118 PMID:22024136 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects secretion		 ISO
EXP		 Minocycline inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]
Minocycline affects the secretion of IL1B protein
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Toluene results in increased expression of IL1B mRNA]		 CTD PMID:11306611 PMID:16386803 PMID:18836210 PMID:19285099 PMID:22024136 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of IL6 protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA] CTD PMID:19285099 PMID:21719015 PMID:24530660 PMID:32916201 PMID:35351628 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Minocycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of INA protein] CTD PMID:21561882 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in increased expression of ITGAM protein]; Minocycline inhibits the reaction [Paraquat results in increased phosphorylation of ITGAM protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of ITGAM protein] CTD PMID:36775139 PMID:38189626 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Minocycline results in decreased phosphorylation of and results in decreased activity of and results in decreased expression of JUN protein CTD PMID:17872917 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Minocycline results in increased phosphorylation of MAPK1 protein
Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]		 CTD PMID:36682417 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO Minocycline affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]
Minocycline results in increased phosphorylation of MAPK3 protein		 CTD PMID:36682417 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Minocycline results in decreased phosphorylation of MAPK8 protein CTD PMID:17872917 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein] CTD PMID:21561882 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of MLKL protein] CTD PMID:38459698 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions		 ISO Minocycline results in increased expression of MMP13 mRNA
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]		 CTD PMID:19285099 PMID:20338993 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity
multiple interactions		 ISO
EXP		 Minocycline results in decreased expression of MMP2 protein
Minocycline results in decreased activity of MMP2 protein
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 protein]
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]		 CTD PMID:11835378 PMID:14508231 PMID:16846501 PMID:19285099 PMID:24292262 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA] CTD PMID:19285099 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity		 ISO
EXP		 Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]; Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein]
Minocycline results in decreased expression of MMP9 protein
Minocycline results in decreased activity of MMP9 protein		 CTD PMID:16846501 PMID:18835858 PMID:19285099 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Minocycline affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Minocycline inhibits the reaction [Paraquat affects the localization of NCF1 protein] CTD PMID:38189626 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein] CTD PMID:37394652 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Minocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of NOS2 protein]		 CTD PMID:15485488 PMID:18836210 PMID:19285099 PMID:22952811 PMID:33402167 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ocln occludin increases expression EXP minocycline increases expression of occludin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein] CTD PMID:21561882 NCBI chr 8:46,260,069...46,312,073
Ensembl chr 8:46,261,064...46,279,833 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in increased expression of PDK1 protein] CTD PMID:38189626 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in increased expression of PIK3CB protein] CTD PMID:38189626 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX2 protein] CTD PMID:23562983 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO Minocycline results in increased expression of PRTN3 protein CTD PMID:12900849 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA] CTD PMID:18706994 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Minocycline inhibits the reaction [Cisplatin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of PTGS2 protein] CTD PMID:36775139 PMID:37394652 PMID:37769865 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Minocycline inhibits the reaction [Morphine results in increased expression of PYCARD protein] CTD PMID:37394652 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in decreased expression of RBFOX3 protein]; Minocycline inhibits the reaction [Rotenone results in decreased expression of RBFOX3 protein] CTD PMID:33402167 PMID:38189626 NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression ISO Minocycline affects the expression of RELA protein CTD PMID:17898303 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of RIPK3 protein] CTD PMID:38459698 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects expression ISO Minocycline affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Minocycline affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:3,403,418...3,479,476 JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Minocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA] CTD PMID:24292262 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Minocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; Minocycline inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein] CTD PMID:16839653 PMID:38189626 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein] CTD PMID:21561882 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein] CTD PMID:23562983 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stmn1 stathmin 1 multiple interactions EXP
ISO		 Minocycline inhibits the reaction [cypermethrin results in decreased expression of STMN1 protein]
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]		 CTD PMID:21561882 PMID:23562983 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 EXP Minocycline results in increased expression of TGFB1 mRNA
Minocycline inhibits the reaction [Toluene results in decreased expression of TGFB1 mRNA]		 CTD PMID:32234516 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein CTD PMID:20606027 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Minocycline inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:38189626 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [manganese chloride results in increased expression of TNF protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of TNF protein]
Minocycline results in decreased expression of TNF mRNA
Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Morphine results in increased expression of TNF protein]; Minocycline inhibits the reaction [Paraquat results in increased expression of TNF protein]; Minocycline inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]		 CTD PMID:14588118 PMID:15485488 PMID:18836210 PMID:19285099 PMID:21719015 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Minocycline results in decreased expression of TP53 protein CTD PMID:15172883 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP Minocycline results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 multiple interactions ISO Minocycline inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TREM2 mRNA] CTD PMID:35351628 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Minocycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFC mRNA] CTD PMID:24292262 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFD mRNA] CTD PMID:24292262 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline promotes the reaction [HIF1A protein binds to VHL protein] CTD PMID:24292262 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein] CTD PMID:22245251 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression
multiple interactions		 EXP
ISO		 Minocycline results in increased expression of XIAP protein
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein		 CTD PMID:14998631 PMID:20606027 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          tetracenomycin 112
            minocycline 112
              minocycline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            organic hydride 18711
                              organic fundamental parent 18711
                                hydrocarbon 18454
                                  cyclic hydrocarbon 17239
                                    arene 17220
                                      polycyclic arene 17045
                                        ortho-fused polycyclic arene 9848
                                          acene 7798
                                            tetracene 7795
                                              tetracyclines 526
                                                minocycline 112
                                                  minocycline hydrochloride 0
paths to the root