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G |
Adra2a |
adrenoceptor alpha 2A |
multiple interactions |
ISO EXP |
Brimonidine Tartrate inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] |
CTD |
PMID:8397342 PMID:10742289 PMID:12208771 PMID:12598592 |
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NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] |
CTD |
PMID:18250367 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
Brimonidine Tartrate inhibits the reaction [CFTR protein affects the transport of Chlorides] |
CTD |
PMID:12598592 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation |
EXP |
Brimonidine Tartrate results in increased phosphorylation of CREB1 protein |
CTD |
PMID:17680988 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Prkca |
protein kinase C, alpha |
affects localization multiple interactions |
EXP |
Brimonidine Tartrate affects the localization of PRKCA protein Nitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein] |
CTD |
PMID:12388232 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcd |
protein kinase C, delta |
affects localization multiple interactions |
EXP |
Brimonidine Tartrate affects the localization of PRKCD protein Nitric Oxide deficiency inhibits the reaction [Brimonidine Tartrate affects the localization of PRKCD protein] |
CTD |
PMID:12388232 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
EXP |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] |
CTD |
PMID:18250367 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Brimonidine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein] |
CTD |
PMID:1218171 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity |
ISO |
Tolterodine Tartrate results in decreased activity of ABCB4 protein |
CTD |
PMID:28437613 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of ACSL4 protein] |
CTD |
PMID:37702107 |
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NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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G |
Ahr |
aryl hydrocarbon receptor |
decreases expression |
ISO |
Tolterodine Tartrate results in decreased expression of AHR mRNA |
CTD |
PMID:24316275 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
ISO |
Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein |
CTD |
PMID:15140916 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions |
ISO |
Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein |
CTD |
PMID:15140916 |
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NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing affects metabolic processing multiple interactions |
ISO |
CYP2D6 protein results in increased metabolism of Tolterodine Tartrate CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] |
CTD |
PMID:10583026 PMID:28087463 |
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NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of FTH1 protein] |
CTD |
PMID:37702107 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX4 protein] |
CTD |
PMID:37702107 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Il1b |
interleukin 1 beta |
decreases expression multiple interactions |
ISO |
Tolterodine Tartrate results in decreased expression of IL1B mRNA Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:32816093 PMID:37702107 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:37702107 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] |
CTD |
PMID:37702107 |
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions decreases expression |
ISO |
Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA] Tolterodine Tartrate results in decreased expression of NR3C1 mRNA |
CTD |
PMID:24316275 |
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NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:37702107 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:37702107 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Tolterodine Tartrate results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Tfrc |
transferrin receptor |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of TFRC protein] |
CTD |
PMID:37702107 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:37702107 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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