vasoconstrictor agent - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	vasoconstrictor agent	go back to main search page
Accession:	CHEBI:50514	browse the term
Definition:	Drug used to cause constriction of the blood vessels.

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Rat (2051 ) Mouse (2039 ) Human (2037 ) Chinchilla (0 ) Bonobo (0 ) Dog (9 ) Squirrel (0 ) Pig (4 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (2051)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

ISO
EXP

Ephedrine inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
Ephedrine results in increased expression of ACTA2 protein

PMID:32729338 PMID:37778983

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

apolipoprotein A1

multiple interactions

ISO

[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein A2

multiple interactions

ISO

[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein

NCBI chr13:86,176,767...86,178,819
Ensembl chr13:86,174,741...86,179,410

G

apolipoprotein B

multiple interactions

ISO

[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein C1

multiple interactions

ISO

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein

NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:88,474,663...88,478,155

G

apolipoprotein C2

multiple interactions

ISO

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein

NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:88,457,396...88,463,438

G

apolipoprotein C3

multiple interactions

ISO

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

Ephedrine results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

EXP

Ephedrine results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases activity

EXP

[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Ephedrine results in increased activity of CASP3 protein

PMID:15537744 PMID:32729338

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases activity

EXP

Ephedrine results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cadherin 1

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

complement factor D

multiple interactions

ISO

[Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein]

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Ephedrine results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutamic--pyruvic transaminase

increases expression

EXP

Ephedrine results in increased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

H2A.X variant histone

multiple interactions

EXP

[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

interleukin 1 beta

increases expression

EXP

Ephedrine results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

ISO
EXP

Ephedrine inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
Ephedrine results in increased expression of IL6 protein

PMID:32729338 PMID:37778983

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

keratin 8

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 protein]

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NADPH oxidase 1

increases expression

EXP

Ephedrine results in increased expression of NOX1 protein

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

SMAD family member 3

increases expression

EXP

Ephedrine results in increased expression of SMAD3 mRNA; Ephedrine results in increased expression of SMAD3 protein

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 7

decreases expression

EXP

Ephedrine results in decreased expression of SMAD7 protein

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849

G

transforming growth factor, beta 1

increases expression

EXP

Ephedrine results in increased expression of TGFB1 mRNA; Ephedrine results in increased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
increases expression

ISO
EXP

Ephedrine inhibits the reaction [Bleomycin results in increased secretion of TNF protein]
Ephedrine results in increased expression of TNF protein

PMID:32729338 PMID:37778983

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vimentin

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions
increases export

EXP

[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite
ABCC1 protein results in increased export of Epinephrine metabolite

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

aconitase 2

increases expression

EXP

Epinephrine results in increased expression of ACO2 protein

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

actinin, alpha 1

increases expression

EXP

Epinephrine results in increased expression of ACTN1 protein

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172

G

adiponectin, C1Q and collagen domain containing

multiple interactions
decreases expression

EXP

Sildenafil Citrate inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein]; Tadalafil inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adrenoceptor alpha 1A

multiple interactions
increases activity
affects binding

EXP
ISO

[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; Epinephrine binds to and results in increased activity of ADRA1A protein
Epinephrine results in increased activity of ADRA1A protein
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1A protein; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
Epinephrine binds to ADRA1A protein

PMID:8183249 PMID:15306222 PMID:15672411 PMID:20030735

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

multiple interactions
increases activity

ISO

[Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1B protein; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]

PMID:15306222 PMID:20030735

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

affects binding
increases activity
multiple interactions

ISO

Epinephrine binds to ADRA1D protein
Epinephrine results in increased activity of ADRA1D protein
[Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1D protein; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]

PMID:8183249 PMID:15306222 PMID:20030735

NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:139,246,323...139,262,331

G

adrenoceptor alpha 2A

increases activity
multiple interactions

EXP
ISO

Epinephrine results in increased activity of ADRA2A protein
[Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2A protein; Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein]

PMID:17341653 PMID:17680988 PMID:20030735 PMID:30737458

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

multiple interactions

ISO

[Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2B protein; Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]

PMID:17680988 PMID:20030735

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor alpha 2C

multiple interactions

ISO

[Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2C protein; Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]

PMID:17680988 PMID:20030735

NCBI chr14:79,695,514...79,697,476
Ensembl chr14:79,694,995...79,706,656

G

adrenoceptor beta 1

multiple interactions
increases activity

ISO
EXP

[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine
Epinephrine results in increased activity of ADRB1 protein
Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; columbamine inhibits the reaction [Epinephrine results in increased activity of ADRB1 protein]; epiberberine affects the reaction [Epinephrine results in increased activity of ADRB1 protein]; Epinephrine binds to and results in increased activity of ADRB1 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Harmaline affects the reaction [Epinephrine results in increased activity of ADRB1 protein]; Harmine affects the reaction [Epinephrine results in increased activity of ADRB1 protein]; Nebivolol inhibits the reaction [Epinephrine results in increased activity of ADRB1 protein]; nuciferine affects the reaction [Epinephrine results in increased activity of ADRB1 protein]; palmatine inhibits the reaction [Epinephrine results in increased activity of ADRB1 protein]; Propranolol inhibits the reaction [Epinephrine results in increased activity of ADRB1 protein]

PMID:8096834 PMID:12010770 PMID:14730417 PMID:30155694

NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237

G

adrenoceptor beta 2

multiple interactions
affects response to substance
increases activity

ISO
EXP

3,4-dihydroxyphenyllactic acid inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; [Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; anhydroicaritin inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; columbamine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; Emodin inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; epiberberine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; Epinephrine binds to and results in increased activity of ADRB2 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein; Harmaline inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; Harmine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; liquiritin inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; nuciferine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; palmatine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; protopine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; Synephrine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]; tetrahydrocolumbamine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
ADRB2 affects the susceptibility to Epinephrine

PMID:1389726 PMID:11164953 PMID:12920204 PMID:14722251 PMID:14730417 More...

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

adrenoceptor beta 3

multiple interactions

EXP
ISO

Epinephrine binds to and results in increased activity of ADRB3 protein
[Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB3 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]

PMID:1682311 PMID:7815362 PMID:14730417

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

adenylate kinase 2

decreases expression
multiple interactions

EXP

Epinephrine results in decreased expression of AK2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein

NCBI chr 5:146,609,469...146,649,008
Ensembl chr 5:146,630,445...146,650,610

G

AKT serine/threonine kinase 1

multiple interactions

ISO

[Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

amine oxidase, copper containing 1

multiple interactions
increases activity

EXP

Cycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]

NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:79,143,126...79,162,704

G

aquaporin 7

affects localization
multiple interactions
increases expression

ISO

Epinephrine affects the localization of AQP7 protein
INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]

NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:60,967,558...60,982,618

G

ATP synthase F1 subunit alpha

increases expression

EXP

Epinephrine results in increased expression of ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

BCL2, apoptosis regulator

increases expression

ISO

Epinephrine results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bone morphogenetic protein 2

decreases expression

ISO

Epinephrine results in decreased expression of BMP2 mRNA; Epinephrine results in decreased expression of BMP2 protein

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

complement C1q binding protein

multiple interactions
increases expression

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein
Epinephrine results in increased expression of C1QBP protein

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235

G

calcitonin-related polypeptide alpha

increases abundance

EXP

CALCA protein results in increased abundance of Epinephrine

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

calcyon neuron-specific vesicular protein

decreases secretion

ISO

CALY protein results in decreased secretion of Epinephrine

NCBI chr 1:204,292,317...204,303,506
Ensembl chr 1:204,292,318...204,303,196

G

carbonic anhydrase 2

increases expression

ISO

Epinephrine results in increased expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 3

multiple interactions
increases expression
increases activity

ISO
EXP

Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
Epinephrine results in increased expression of CASP3 protein
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Tadalafil inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Vardenafil Dihydrochloride inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]

PMID:10728402 PMID:19135123 PMID:29233027

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases response to substance

ISO

CAT results in decreased susceptibility to Epinephrine

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 3

multiple interactions

ISO

Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]; Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]]
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Epinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]

PMID:9863660 PMID:12538206

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cyclin D1

multiple interactions
increases expression

EXP
ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]
Epinephrine results in increased expression of CCND1 mRNA; Epinephrine results in increased expression of CCND1 protein
ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]

PMID:17680988 PMID:26964897

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

CCAAT/enhancer binding protein beta

decreases expression

ISO

Epinephrine results in decreased expression of CEBPB protein

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

ISO

[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858

G

catechol-O-methyltransferase

increases methylation
multiple interactions

ISO
EXP

COMT protein results in increased methylation of Epinephrine
[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine

PMID:8821542 PMID:10064789 PMID:11160877 PMID:11248589

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

cAMP responsive element binding protein 1

multiple interactions
increases phosphorylation

ISO
EXP

ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]

PMID:17680988 PMID:22496244

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

corticotropin releasing hormone

multiple interactions
increases abundance

EXP

corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]
CRH results in increased abundance of Epinephrine

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

C-terminal Src kinase

multiple interactions

ISO

CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]]

NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274

G

catenin beta 1

increases phosphorylation
multiple interactions

EXP

Epinephrine results in increased phosphorylation of CTNNB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin K

increases expression

ISO

Epinephrine results in increased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cytochrome c, somatic

multiple interactions
increases expression

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein
Epinephrine results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

dopamine beta-hydroxylase

affects abundance

ISO

DBH gene polymorphism affects the abundance of Epinephrine

NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316

G

desmin

multiple interactions
decreases expression

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein
Epinephrine results in decreased expression of DES protein

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

dihydrolipoamide S-acetyltransferase

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

enoyl-CoA hydratase, short chain 1

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

Eph receptor A4

increases phosphorylation

ISO

Epinephrine results in increased phosphorylation of EPHA4 protein

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

electron transfer flavoprotein subunit beta

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein

NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:102,988,499...103,002,659

G

fatty acid binding protein 3

affects expression
multiple interactions

EXP

Epinephrine affects the expression of FABP3 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

Fas cell surface death receptor

multiple interactions
increases expression

ISO

Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions
increases expression

ISO

Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fumarate hydratase

increases expression

EXP

Epinephrine results in increased expression of FH protein

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

forkhead box O1

decreases expression

ISO

Epinephrine results in decreased expression of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

G protein subunit beta 2

multiple interactions

ISO

Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]

NCBI chr12:24,795,505...24,800,796
Ensembl chr12:24,795,827...24,800,796

G

G protein subunit beta 4

multiple interactions

ISO

Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]

NCBI chr 2:117,289,112...117,329,050
Ensembl chr 2:117,293,284...117,328,945

G

G protein subunit gamma 12

multiple interactions

ISO

Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]

NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476

G

G protein subunit gamma 2

multiple interactions

ISO

Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]

NCBI chr15:4,365,222...4,466,060
Ensembl chr15:4,365,135...4,466,059

G

G protein subunit gamma 3

multiple interactions

ISO

Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]

NCBI chr 1:215,160,952...215,162,718
Ensembl chr 1:215,160,952...215,162,718

G

G protein subunit gamma 4

multiple interactions

ISO

Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein]

NCBI chr17:93,432,791...93,481,709
Ensembl chr17:93,433,195...93,481,709

G

G protein-coupled receptor kinase 2

multiple interactions

ISO

Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]

NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015

G

G protein-coupled receptor kinase 5

multiple interactions

ISO

Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928

G

hydroxyacyl-CoA dehydrogenase

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

hypoxia inducible factor 1 subunit alpha

increases expression

ISO

Epinephrine results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hexokinase 2

increases expression

ISO

Epinephrine results in increased expression of HK2 protein

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

heat shock transcription factor 1

multiple interactions
affects localization

EXP

Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]
Epinephrine affects the localization of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein 90 alpha family class B member 1

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 8

increases expression

EXP

Epinephrine results in increased expression of HSPA8 protein

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family A (Hsp70) member 9

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

heat shock protein family B (small) member 6

decreases expression
multiple interactions

EXP

Epinephrine results in decreased expression of HSPB6 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein

NCBI chr 1:94,934,372...94,936,516
Ensembl chr 1:94,933,543...94,936,512

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression
multiple interactions

EXP

Epinephrine results in decreased expression of IDH2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

interleukin 10

multiple interactions

ISO

Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO

Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

decreases expression
multiple interactions

EXP
ISO

Epinephrine results in decreased expression of IL6 mRNA
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:10588509 PMID:12423672

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

ISO
EXP

INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]
cilostamide inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; Cytochalasin B inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]

PMID:10777495 PMID:15172182

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions
decreases expression

ISO

[Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]; Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein]

PMID:1218171 PMID:6018752 PMID:6314140 PMID:32305330

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

integrin subunit alpha 2

multiple interactions

ISO

ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509

G

integrin subunit alpha V

increases expression

ISO

Epinephrine results in increased expression of ITGAV mRNA

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

integrin subunit beta 1

increases response to substance

EXP

ITGB1 results in increased susceptibility to Epinephrine

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

lipase E, hormone sensitive type

multiple interactions
increases expression
affects localization
increases activity

ISO
EXP

Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]
Epinephrine results in increased expression of LIPE mRNA
Epinephrine affects the localization of LIPE protein

PMID:7155675 PMID:10777495 PMID:11160373

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity
affects activity

ISO
EXP

ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]
Epinephrine deficiency results in increased activity of MAPK1 protein
Epinephrine affects the activity of MAPK1 protein

PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity
affects activity

ISO
EXP

ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]
Epinephrine deficiency results in increased activity of MAPK3 protein
Epinephrine affects the activity of MAPK3 protein

PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

Meis homeobox 1

decreases expression

ISO

Epinephrine results in decreased expression of MEIS1 protein

NCBI chr14:97,356,949...97,499,646
Ensembl chr14:97,322,748...97,495,083

G

myosin light chain 2

multiple interactions
affects expression

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein
Epinephrine affects the expression of MYL2 protein

NCBI chr12:40,114,964...40,126,236
Ensembl chr12:40,114,958...40,129,149

G

neurofilament heavy chain

affects expression

EXP

Epinephrine affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 2

multiple interactions
increases expression

ISO
EXP

Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Epinephrine results in increased expression of NOS2 mRNA

PMID:16925470 PMID:19439816

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

neurotrophin 3

increases expression

EXP

Epinephrine results in increased expression of NTF3 mRNA; Epinephrine results in increased expression of NTF3 protein

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

purinergic receptor P2X 7

decreases activity

ISO

Epinephrine results in decreased activity of P2RX7 protein

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

purinergic receptor P2Y12

multiple interactions

ISO

Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate]

NCBI chr 2:145,631,487...145,673,194
Ensembl chr 2:145,629,967...145,633,410

G

poly (ADP-ribose) polymerase 1

decreases cleavage

ISO

Epinephrine results in decreased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

increases expression

ISO

Epinephrine results in increased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

prohibitin 1

multiple interactions
increases expression

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein
Epinephrine results in increased expression of PHB1 protein

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233

G

phosphoglycerate dehydrogenase

increases expression

EXP

Epinephrine results in increased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

pyruvate kinase M1/2

multiple interactions
increases expression

EXP
ISO

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein
Epinephrine results in increased expression of PKM protein

PMID:19464573 PMID:36423730

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

PPARG coactivator 1 alpha

increases expression

EXP

Epinephrine results in increased expression of PPARGC1A mRNA

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein phosphatase 2 scaffold subunit A alpha

decreases expression
multiple interactions

EXP

Epinephrine results in decreased expression of PPP2R1A protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein

NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242

G

peroxiredoxin 6

multiple interactions
decreases expression

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein
Epinephrine results in decreased expression of PRDX6 protein

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657

G

protein kinase C, epsilon

affects response to substance

ISO
EXP

PRKCE protein affects the susceptibility to Epinephrine

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Epinephrine results in decreased expression of PTGS2 mRNA; Epinephrine results in decreased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

renin

multiple interactions
increases activity

ISO

ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein]

PMID:6314140 PMID:8592096

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

secretin

multiple interactions

EXP

Epinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP]

NCBI chr 1:205,812,435...205,813,246
Ensembl chr 1:205,812,435...205,813,246

G

serpin family E member 1

increases expression

ISO

Epinephrine results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

solute carrier family 22 member 3

multiple interactions
increases uptake

EXP
ISO

[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine
SLC22A3 protein results in increased uptake of Epinephrine

PMID:19053318 PMID:20858707

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 29 member 4

increases uptake

ISO

SLC29A4 protein results in increased uptake of Epinephrine

NCBI chr12:16,967,047...16,998,276
Ensembl chr12:16,967,047...16,988,338

G

superoxide dismutase 1

multiple interactions
affects binding
increases expression
increases activity

ISO
EXP

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Epinephrine binds to SOD1 protein mutant form
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 protein

PMID:11163531 PMID:19464573 PMID:23612299

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
increases expression
increases activity

ISO
EXP

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 mRNA; Epinephrine results in increased expression of SOD2 protein

PMID:11163531 PMID:19464573

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

succinate-CoA ligase GDP-forming subunit beta

increases expression

EXP

Epinephrine results in increased expression of SUCLG2 protein

NCBI chr 4:129,623,833...129,893,937
Ensembl chr 4:129,623,834...129,937,296

G

tyrosine hydroxylase

increases chemical synthesis
multiple interactions

ISO
EXP

TH protein results in increased chemical synthesis of Epinephrine
[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine

PMID:9822156 PMID:19067675

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

Thy-1 cell surface antigen

multiple interactions
decreases expression

ISO

Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1]

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

tumor necrosis factor

multiple interactions
decreases expression
decreases secretion

ISO
EXP

Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Epinephrine results in decreased expression of TNF mRNA
Epinephrine results in decreased secretion of TNF protein

PMID:10588509 PMID:12423672

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

decreases expression

ISO

Epinephrine results in decreased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

voltage-dependent anion channel 1

increases expression
multiple interactions

EXP

Epinephrine results in increased expression of VDAC1 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

Wnt family member 4

decreases expression

ISO

Epinephrine results in decreased expression of WNT4 mRNA; Epinephrine results in decreased expression of WNT4 protein

NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128

G

xanthine dehydrogenase

multiple interactions

EXP

[Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]

PMID:19135123 PMID:19464573

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

(R)-noradrenaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aralkylamine N-acetyltransferase

multiple interactions
increases activity

EXP

11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid inhibits the reaction [Norepinephrine results in increased activity of AANAT protein]; Cannabidiol inhibits the reaction [Norepinephrine results in increased activity of AANAT protein]; Cannabinol inhibits the reaction [Norepinephrine results in increased activity of AANAT protein]

NCBI chr10:102,323,647...102,330,639
Ensembl chr10:102,326,135...102,330,635

G

actin, alpha 1, skeletal muscle

increases expression

EXP

Norepinephrine results in increased expression of ACTA1 mRNA

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

ISO

Norepinephrine results in increased expression of ACTA2 mRNA
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]; Carnosine inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adenosine deaminase

multiple interactions
decreases response to substance

ISO
EXP

[ADA protein co-treated with Norepinephrine] results in increased secretion of Glycerol
Propranolol promotes the reaction [ADA protein results in decreased susceptibility to Norepinephrine]

PMID:7949234 PMID:17428236

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293

G

adrenoceptor alpha 1A

affects binding
multiple interactions
increases activity
affects expression
affects response to substance

ISO
EXP

Norepinephrine binds to ADRA1A protein
[Norepinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1A protein; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]
Norepinephrine results in increased activity of ADRA1A protein
5-methylurapidil inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; BMY 7378 inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; chlorethylclonidine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Spiperone inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]
Norepinephrine affects the expression of ADRA1A protein
ADRA1A protein affects the susceptibility to Norepinephrine

PMID:8183249 PMID:10416824 PMID:12417256 PMID:20030735

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

multiple interactions

ISO

[Norepinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1B protein; Norepinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

affects binding
multiple interactions
affects response to substance

ISO
EXP

Norepinephrine binds to ADRA1D protein
[Norepinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1D protein; Norepinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]
ADRA1D affects the susceptibility to Norepinephrine
Norepinephrine binds to and affects the activity of ADRA1D protein

PMID:8183249 PMID:9639061 PMID:11901185 PMID:15493479 PMID:20030735

NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:139,246,323...139,262,331

G

adrenoceptor alpha 2A

affects secretion
multiple interactions
affects abundance
affects binding

EXP
ISO

ADRA2A protein affects the secretion of Norepinephrine
[ADRA2A protein mutant form co-treated with ADRA2C protein mutant form] results in increased abundance of Norepinephrine
ADRA2A protein affects the abundance of Norepinephrine
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; [Norepinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; Brimonidine Tartrate inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Dexmedetomidine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Doxazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Norepinephrine binds to and results in increased activity of ADRA2A protein; Norepinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Prazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; talipexole inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Yohimbine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]
Norepinephrine binds to ADRA2A protein
[BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]]

PMID:10336518 PMID:10742289 PMID:11312645 PMID:20030735 PMID:20083574

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

multiple interactions

ISO

[Norepinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA2B protein; Norepinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor alpha 2C

affects binding
multiple interactions

ISO

Norepinephrine binds to ADRA2C protein
[ADRA2A protein mutant form co-treated with ADRA2C protein mutant form] results in increased abundance of Norepinephrine
[Norepinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA2C protein; Norepinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]

PMID:10336518 PMID:20030735 PMID:20083574

NCBI chr14:79,695,514...79,697,476
Ensembl chr14:79,694,995...79,706,656

G

adrenoceptor beta 1

multiple interactions

ISO
EXP

[Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB1 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]; Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]
[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Norepinephrine

PMID:8096834 PMID:10344530 PMID:12010770 PMID:14730417 PMID:17200720

NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237

G

adrenoceptor beta 2

multiple interactions
affects binding

EXP
ISO

[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]
Norepinephrine binds to ADRB2 protein
[Norepinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB2 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]; Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]

PMID:7969507 PMID:10344530 PMID:14730417 PMID:24929186

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

adrenoceptor beta 3

multiple interactions
increases activity

ISO
EXP

[Norepinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB3 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]
Norepinephrine results in increased activity of ADRB3 protein
3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Norepinephrine results in increased activity of ADRB3 protein]; Norepinephrine binds to and results in increased activity of ADRB3 protein

PMID:1682311 PMID:7815362 PMID:8569714 PMID:10344530 PMID:14730417 More...

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

angiotensinogen

increases abundance
affects abundance
multiple interactions

EXP

AGT protein results in increased abundance of Norepinephrine
Norepinephrine affects the abundance of AGT protein
carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]

PMID:614752 PMID:15741261

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

affects response to substance

ISO

AGTR2 protein affects the susceptibility to Norepinephrine

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

AKT serine/threonine kinase 1

decreases expression

EXP

Norepinephrine results in decreased expression of AKT1 protein modified form

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arachidonate 5-lipoxygenase activating protein

increases expression

EXP

Norepinephrine results in increased expression of ALOX5AP mRNA

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

annexin A1

multiple interactions

ISO

ANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein]

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

aquaporin 2

decreases expression

EXP

Norepinephrine results in decreased expression of AQP2 protein

NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

affects abundance
decreases expression

ISO
EXP

ATP2A2 protein affects the abundance of Norepinephrine
Norepinephrine results in decreased expression of ATP2A2 mRNA

PMID:17592507 PMID:19328205

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

arginine vasopressin

multiple interactions

EXP

[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

EXP

N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of BAX protein]
Norepinephrine results in increased expression of BAX mRNA; Norepinephrine results in increased expression of BAX protein

PMID:18675472 PMID:20374255

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein]

PMID:14732211 PMID:17041759 PMID:20374255

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

EXP

Norepinephrine results in decreased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

bradykinin receptor B2

affects response to substance

ISO

BDKRB2 affects the susceptibility to Norepinephrine

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

complement C5a receptor 2

increases expression

EXP

Norepinephrine results in increased expression of C5AR2 mRNA; Norepinephrine results in increased expression of C5AR2 protein

NCBI chr 1:86,058,557...86,073,583
Ensembl chr 1:86,057,256...86,061,372

G

calcitonin-related polypeptide alpha

affects response to substance
increases abundance
multiple interactions

EXP

CALCA protein affects the susceptibility to Norepinephrine
CALCA protein results in increased abundance of Norepinephrine
Propranolol promotes the reaction [CALCA protein affects the susceptibility to Norepinephrine]

PMID:8058111 PMID:18055875

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

calcyon neuron-specific vesicular protein

increases secretion

ISO

CALY protein results in increased secretion of Norepinephrine

NCBI chr 1:204,292,317...204,303,506
Ensembl chr 1:204,292,318...204,303,196

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

EXP

Norepinephrine results in increased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

caspase 12

multiple interactions
increases cleavage

EXP

CAT protein inhibits the reaction [Norepinephrine results in increased cleavage of CASP12 protein alternative form]

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 2

multiple interactions
increases activity

EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein]

PMID:14732211 PMID:15158148 PMID:17041759

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein]; Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein
Norepinephrine results in increased activity of CASP3 protein
Norepinephrine results in increased cleavage of CASP3 protein
Norepinephrine results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of CASP3 protein]; Norepinephrine inhibits the reaction [Okadaic Acid results in increased activity of CASP3 protein]

PMID:11099166 PMID:14732211 PMID:15158148 PMID:16338971 PMID:17041759 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 6

multiple interactions
increases activity

EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein]

PMID:14732211 PMID:15158148

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726

G

caspase 7

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein]; Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

affects activity

EXP

Norepinephrine affects the activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
affects activity
increases cleavage
increases activity

EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]
Norepinephrine affects the activity of CASP9 protein
Norepinephrine results in increased cleavage of CASP9 protein

PMID:14732211 PMID:15158148 PMID:16338971 PMID:25437044

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

CAT protein inhibits the reaction [Norepinephrine results in increased cleavage of CASP12 protein alternative form]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 3

multiple interactions

ISO

Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Norepinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]; Propranolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

increases secretion
multiple interactions

ISO

Norepinephrine results in increased secretion of CCL5 protein
Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cellular communication network factor 1

increases expression

ISO

Norepinephrine results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

decreases expression

EXP

Norepinephrine results in decreased expression of CITED4 mRNA

NCBI chr 5:139,532,165...139,533,056
Ensembl chr 5:139,531,584...139,533,361

G

cannabinoid receptor 1

affects expression

ISO

Norepinephrine affects the expression of CNR1 mRNA

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

collagen type I alpha 1 chain

multiple interactions
increases expression

EXP
ISO

carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]

PMID:10722803 PMID:14577597 PMID:19575289 PMID:34609854

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

increases expression
multiple interactions

EXP
ISO

Norepinephrine results in increased expression of COL3A1 mRNA
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]; Carnosine inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]
carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]

PMID:10722803 PMID:14577597 PMID:34609854

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

catechol-O-methyltransferase

multiple interactions
increases methylation

ISO

[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine
COMT protein results in increased methylation of Norepinephrine

PMID:11160877 PMID:11248589

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

carnitine palmitoyltransferase 1A

decreases expression

EXP

Norepinephrine results in decreased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

cAMP responsive element modulator

increases expression

ISO

Norepinephrine results in increased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

corticotropin releasing hormone

multiple interactions
increases abundance

EXP

corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Norepinephrine]; Norepinephrine affects the expression of and affects the secretion of CRH protein; Propranolol affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]; Yohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]
CRH results in increased abundance of Norepinephrine

PMID:1320258 PMID:3497798

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

corticotropin releasing hormone receptor 1

multiple interactions

EXP

[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]

NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466

G

carnitine O-octanoyltransferase

increases expression

EXP

Norepinephrine results in increased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064

G

cytochrome c, somatic

affects localization
increases localization

EXP

Norepinephrine affects the localization of CYCS protein
Norepinephrine results in increased localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

dopamine beta-hydroxylase

affects abundance
increases abundance
decreases abundance

ISO

DBH gene polymorphism affects the abundance of Norepinephrine
DBH protein results in increased abundance of Norepinephrine
DBH mutant form results in decreased abundance of Norepinephrine

PMID:15148402 PMID:16163519 PMID:18329701

NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316

G

DNA-damage inducible transcript 3

increases expression

EXP

Norepinephrine results in increased expression of DDIT3 mRNA; Norepinephrine results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dynamin 2

decreases expression

EXP

Norepinephrine results in decreased expression of DNM2 mRNA

NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:28,254,529...28,336,295

G

dopamine receptor D1

multiple interactions

EXP

Norepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Norepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 protein]

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions

ISO
EXP

[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]

PMID:8032591 PMID:20887679

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

endothelin 1

multiple interactions
increases expression
increases activity
decreases secretion
increases secretion

EXP

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; [EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]
Norepinephrine results in increased activity of EDN1 promoter

PMID:11435416 PMID:12184995 PMID:14759557 PMID:16023617

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin 3

multiple interactions
decreases secretion
increases secretion

EXP

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; 2-aminoethoxydiphenyl borate inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; [EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; bisindolylmaleimide I inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]; KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]; Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]

PMID:12184995 PMID:14759557 PMID:16023617

NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:183,980,668...184,005,329

G

endothelin receptor type A

multiple interactions

EXP

[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

endothelin receptor type B

multiple interactions

EXP

[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; [EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

EF-hand domain family, member D2

increases secretion

ISO

EFHD2 gene mutant form results in increased secretion of Norepinephrine

NCBI chr 5:159,443,959...159,459,993
Ensembl chr 5:159,443,960...159,460,369

G

epidermal growth factor

multiple interactions

EXP

[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA

PMID:11742803 PMID:12632255

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions

EXP

EGFR protein inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

increases expression

EXP

Norepinephrine results in increased expression of EGR1

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

ETS transcription factor ELK1

multiple interactions

EXP

[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein]

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

ELOVL fatty acid elongase 3

multiple interactions
increases expression

ISO

[Dexamethasone co-treated with Norepinephrine] results in increased expression of ELOVL3 mRNA; Dactinomycin inhibits the reaction [Norepinephrine results in increased expression of ELOVL3 mRNA]; Norepinephrine results in increased expression of and results in decreased degradation of ELOVL3 mRNA; rosiglitazone promotes the reaction [[Dexamethasone co-treated with Norepinephrine] results in increased expression of ELOVL3 mRNA]

NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559

G

erythropoietin

decreases response to substance

ISO

EPO protein results in decreased susceptibility to Norepinephrine

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

coagulation factor III, tissue factor

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Norepinephrine promotes the reaction [REL protein binds to F3 promoter]; Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fibroblast growth factor 1

multiple interactions

EXP

[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]

PMID:11742803 PMID:15264218

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393

G

fibroblast growth factor 2

multiple interactions

EXP

[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

FGR proto-oncogene, Src family tyrosine kinase

increases expression

EXP

Norepinephrine results in increased expression of FGR mRNA

NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169

G

fibronectin 1

multiple interactions

ISO

[Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein; [Norepinephrine co-treated with Propranolol] results in increased expression of FN1 protein

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

fibronectin type III domain containing 5

decreases abundance

EXP

FNDC5 protein results in decreased abundance of Norepinephrine

NCBI chr 5:146,765,951...146,775,611
Ensembl chr 5:146,751,416...146,778,540

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

ISO
EXP

Norepinephrine results in increased expression of FOS mRNA
Norepinephrine results in increased expression of FOS; Norepinephrine results in increased expression of FOS mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of FOS mRNA]

PMID:7605896 PMID:7905536 PMID:12729908 PMID:19225867

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Norepinephrine results in increased expression of FOSB

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

forkhead box O3

multiple interactions
increases phosphorylation

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

glucose-6-phosphate dehydrogenase

increases activity
increases expression
multiple interactions

EXP

Norepinephrine results in increased activity of G6PD mRNA; Norepinephrine results in increased activity of G6PD protein
Norepinephrine results in increased expression of G6PD mRNA
Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]

PMID:1378361 PMID:7605896

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GA binding protein transcription factor subunit alpha

multiple interactions

EXP

[Progesterone co-treated with Norepinephrine] results in increased expression of GABPA mRNA

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059

G

gap junction protein, alpha 1

increases expression

EXP

Norepinephrine results in increased expression of GJA1 mRNA

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glycerol kinase

increases activity
increases expression

EXP

Norepinephrine results in increased activity of GK protein
Norepinephrine results in increased expression of GK mRNA

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

GNAS complex locus

multiple interactions

ISO

Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein]

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536

G

glypican 3

increases expression

EXP

Norepinephrine results in increased expression of GPC3 mRNA

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

hemoglobin subunit beta

increases expression

EXP

Norepinephrine results in increased expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

histidine decarboxylase

affects abundance

ISO

HDC protein affects the abundance of Norepinephrine

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

heme oxygenase 1

multiple interactions
increases expression

ISO

Propranolol inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

increases expression

EXP

Norepinephrine results in increased expression of HSPA5 mRNA; Norepinephrine results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

5-hydroxytryptamine receptor 2B

multiple interactions
increases expression

EXP

N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of HTR2B protein]

NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:94,190,109...94,204,087

G

intercellular adhesion molecule 1

multiple interactions
increases expression

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]; Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]; Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

insulin-like growth factor 1

multiple interactions
decreases response to substance

EXP

Prazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

interleukin 1 beta

affects secretion
increases expression
multiple interactions

EXP

Norepinephrine affects the secretion of IL1B protein
Norepinephrine results in increased expression of IL1B mRNA
carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]

PMID:8392517 PMID:10722803 PMID:16386803

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases activity
decreases secretion
increases expression

ISO
EXP

Norepinephrine results in increased expression of and results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [Norepinephrine results in increased expression of and results in increased secretion of IL6 protein]
Norepinephrine results in increased activity of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; ICI 118551 inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
Norepinephrine results in decreased secretion of IL6 protein
ANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein]
Norepinephrine results in increased expression of IL6 mRNA; Norepinephrine results in increased expression of IL6 protein

PMID:8392517 PMID:10722803 PMID:11406463 PMID:12619890 PMID:14577597 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

EXP

INS1 protein inhibits the reaction [[Theophylline co-treated with Norepinephrine] results in increased abundance of Cyclic AMP]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation
increases expression

EXP

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of JUN mRNA]
Norepinephrine results in increased expression of JUN; Norepinephrine results in increased expression of JUN mRNA

PMID:7905536 PMID:19225867

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Norepinephrine results in increased expression of JUNB

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

potassium calcium-activated channel subfamily M alpha 1

affects response to substance

EXP

KCNMA1 protein affects the susceptibility to Norepinephrine

NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117

G

luteinizing hormone subunit beta

multiple interactions

EXP

Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein; Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Piperoxan inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Prazosin inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

lipoprotein lipase

multiple interactions
increases expression

EXP

Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

monoamine oxidase A

increases metabolic processing
increases abundance

ISO

MAOA protein results in increased metabolism of Norepinephrine
MAOA mutant form results in increased abundance of Norepinephrine

PMID:10647887 PMID:11834493

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

increases abundance

ISO

MAOB mutant form results in increased abundance of Norepinephrine

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO
EXP

Norepinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
Norepinephrine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]

PMID:10788502 PMID:11054474 PMID:11880281 PMID:11914123 PMID:15292328 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

multiple interactions

ISO

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO
EXP

Norepinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK3 protein; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]

PMID:10788502 PMID:11054474 PMID:11880281 PMID:11914123 PMID:15292328 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions
affects response to substance

ISO

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

matrix metallopeptidase 2

multiple interactions
increases expression
increases activity

EXP
ISO

Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Norepinephrine results in increased activity of and results in increased expression of MMP2 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased activity of MMP2 protein]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]

PMID:14577597 PMID:15326086 PMID:16864425 PMID:24929186

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
increases expression
increases activity

EXP
ISO

trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]
Norepinephrine results in increased activity of MMP9 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; SR 11302 inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]

PMID:16864425 PMID:24929186

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

metallothionein 3

increases expression

EXP

Norepinephrine results in increased expression of MT3 mRNA

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression

EXP

[EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA
Norepinephrine results in increased expression of MYC

PMID:7605896 PMID:12632255

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin heavy chain 11

increases expression

EXP

Norepinephrine results in increased expression of MYH11 mRNA

NCBI chr10:1,250,554...1,345,681
Ensembl chr10:1,263,194...1,345,678

G

myosin heavy chain 6

decreases expression

EXP

Norepinephrine results in decreased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

multiple interactions
affects expression
increases expression

EXP

Propranolol promotes the reaction [Norepinephrine results in increased expression of MYH7 mRNA]
Norepinephrine affects the expression of MYH7 mRNA

PMID:17592507 PMID:25437044

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin, light chain 1

multiple interactions
increases phosphorylation

ISO
EXP

PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]
chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]; CRT 0066101 inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]; fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]

Ensembl chr 9:75,887,227...75,907,971

G

myosin light chain 3

decreases expression

EXP

Norepinephrine results in decreased expression of MYL3 mRNA

NCBI chr 8:119,617,077...119,623,215
Ensembl chr 8:119,616,868...119,623,216

G

N-acetylated alpha-linked acidic dipeptidase 2

decreases expression

EXP

Norepinephrine results in decreased expression of NAALAD2 mRNA

NCBI chr 8:23,682,499...23,756,066
Ensembl chr 8:23,683,395...23,756,060

G

NFE2 like bZIP transcription factor 2

increases expression

EXP

Norepinephrine results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor, interleukin 3 regulated

increases expression

ISO

Norepinephrine results in increased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

nuclear factor kappa B subunit 1

multiple interactions
affects localization

ISO

Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Norepinephrine affects the localization of [NFKB1 protein binds to RELA protein]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]; Norepinephrine results in increased activity of [NFKB1 protein binds to RELA protein]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]

PMID:16782692 PMID:23114885

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nerve growth factor

decreases expression

EXP

Norepinephrine results in decreased expression of NGF mRNA; Norepinephrine results in decreased expression of NGF protein

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nitric oxide synthase 2

multiple interactions
affects response to substance

ISO

[GW 274150 results in decreased activity of NOS2 protein] which results in increased susceptibility to Norepinephrine; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Norepinephrine

PMID:16424707 PMID:19439816

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

natriuretic peptide A

increases expression
multiple interactions

ISO
EXP

Norepinephrine results in increased expression of NPPA mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Norepinephrine results in increased expression of NPPA mRNA]

PMID:9788975 PMID:10722803 PMID:14577597 PMID:14618266 PMID:15240149 More...

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

affects abundance
decreases abundance

ISO

NPPB affects the abundance of Norepinephrine
NPPB protein results in decreased abundance of Norepinephrine

PMID:16333235 PMID:20339970

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

neuropeptide Y

affects response to substance

ISO

NPY protein affects the susceptibility to Norepinephrine

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

nuclear respiratory factor 1

multiple interactions

EXP

[Estradiol co-treated with Norepinephrine] results in decreased expression of NRF1 mRNA

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

neurotrophin 3

increases expression

EXP

Norepinephrine results in increased expression of NTF3 mRNA; Norepinephrine results in increased expression of NTF3 protein

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

ornithine decarboxylase 1

decreases activity

EXP

Norepinephrine results in decreased activity of ODC1 protein

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

opioid receptor, delta 1

multiple interactions

EXP

[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

multiple interactions

EXP

[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

multiple interactions

EXP

[dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

p21 (RAC1) activated kinase 3

decreases expression

EXP

Norepinephrine results in decreased expression of PAK3 mRNA

NCBI chr X:111,912,967...112,171,037
Ensembl chr X:111,913,059...112,165,035

G

peptidylglycine alpha-amidating monooxygenase

increases expression

EXP

Norepinephrine results in increased expression of PAM mRNA

NCBI chr 9:105,445,812...105,719,287
Ensembl chr 9:105,445,929...105,719,285

G

period circadian regulator 1

increases expression

ISO

Norepinephrine results in increased expression of PER1 mRNA

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

increases expression

ISO

Norepinephrine results in increased expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

peroxisomal biogenesis factor 2

increases expression

EXP

Norepinephrine results in increased expression of PEX2 mRNA

NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:97,948,443...97,981,092

G

phosphogluconate dehydrogenase

multiple interactions
increases activity

EXP

carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein]

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

increases expression

EXP

Norepinephrine results in increased expression of PIK3C3 mRNA

NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539

G

phospholipase C beta 1

increases activity
multiple interactions
increases expression

EXP

Norepinephrine results in increased activity of PLCB1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]
Norepinephrine results in increased expression of PLCB1 mRNA; Norepinephrine results in increased expression of PLCB1 protein

PMID:16714034 PMID:19225867

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

phospholipase C beta 3

increases activity
multiple interactions
increases expression

EXP

Norepinephrine results in increased activity of PLCB3 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]
Norepinephrine results in increased expression of PLCB3 mRNA; Norepinephrine results in increased expression of PLCB3 protein

PMID:16714034 PMID:19225867

NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583

G

phospholipase C, delta 1

increases activity
multiple interactions
increases expression

EXP

Norepinephrine results in increased activity of PLCD1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]
Norepinephrine results in increased expression of PLCD1 mRNA; Norepinephrine results in increased expression of PLCD1 protein

PMID:16714034 PMID:19225867

NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939

G

phospholipase C, gamma 1

increases activity
multiple interactions
increases expression

EXP

Norepinephrine results in increased activity of PLCG1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]
Norepinephrine results in increased expression of PLCG1 mRNA; Norepinephrine results in increased expression of PLCG1 protein

PMID:16714034 PMID:19225867

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

peptidase, mitochondrial processing subunit beta

decreases expression

EXP

Norepinephrine results in decreased expression of PMPCB mRNA

NCBI chr 4:14,189,807...14,202,584
Ensembl chr 4:14,165,844...14,202,615

G

pancreatic lipase

increases expression

EXP

Norepinephrine results in increased expression of PNLIP mRNA

NCBI chr 1:267,760,073...267,797,797
Ensembl chr 1:267,784,724...267,797,795

G

peroxisome proliferator activated receptor alpha

increases expression

EXP

Norepinephrine results in increased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

increases expression

EXP

Norepinephrine results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions
increases expression

ISO
EXP

[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]
Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]

PMID:16513826 PMID:16954335

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein phosphatase 1, regulatory subunit 12A

increases phosphorylation
multiple interactions

EXP
ISO

Norepinephrine results in increased phosphorylation of PPP1R12A protein
PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]
CRT 0066101 inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

protein phosphatase 1, regulatory (inhibitor) subunit 14A

increases phosphorylation
multiple interactions

EXP

Norepinephrine results in increased phosphorylation of PPP1R14A protein
chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R14A protein]

NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147

G

protein kinase D1

multiple interactions
increases phosphorylation

ISO
EXP

PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]; PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]
CRT 0066101 inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKD1 protein]

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

phosphatase and tensin homolog

multiple interactions

EXP

[Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA; [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNA; Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Norepinephrine

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

glycogen phosphorylase, muscle associated

affects expression

EXP

Norepinephrine affects the expression of PYGM mRNA

NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:213,119,791...213,134,612

G

REL proto-oncogene, NF-kB subunit

multiple interactions
affects localization

ISO

Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of REL protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of REL protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]; Norepinephrine promotes the reaction [REL protein binds to F3 promoter]; Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of REL protein]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine affects the localization of RELA protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]]; Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Norepinephrine affects the localization of [NFKB1 protein binds to RELA protein]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]; Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]; Norepinephrine results in increased activity of [NFKB1 protein binds to RELA protein]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of RELA protein]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of RELA protein]

PMID:16782692 PMID:23114885

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

S100 calcium binding protein A8

increases expression

ISO

Norepinephrine results in increased expression of S100A8 mRNA; Norepinephrine results in increased expression of S100A8 protein

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

S100 calcium binding protein A9

increases expression

ISO

Norepinephrine results in increased expression of S100A9 mRNA; Norepinephrine results in increased expression of S100A9 protein

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

S100 calcium binding protein B

increases expression
affects response to substance

ISO

Norepinephrine results in increased expression of S100B mRNA; Norepinephrine results in increased expression of S100B protein
S100B protein affects the susceptibility to Norepinephrine

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

scaffold attachment factor B

increases expression

EXP

Norepinephrine results in increased expression of SAFB mRNA

NCBI chr 9:1,504,657...1,525,545
Ensembl chr 9:1,504,456...1,525,781

G

stearoyl-CoA desaturase

increases expression

EXP

Norepinephrine results in increased expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

serpin family E member 1

increases expression

ISO

Norepinephrine results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serpin family H member 1

multiple interactions
increases expression

EXP

carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 protein]
Norepinephrine results in increased expression of SERPINH1 mRNA; Norepinephrine results in increased expression of SERPINH1 protein

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

SHC adaptor protein 1

multiple interactions
increases phosphorylation

EXP

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; EGFR protein inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; SHC1 protein affects the reaction [Norepinephrine results in decreased expression of SOD2 protein]; SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; U 0126 inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]

NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914

G

solute carrier family 12 member 1

decreases expression

EXP

Norepinephrine results in decreased expression of SLC12A1 protein

NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:132,859,590...132,936,340

G

solute carrier family 14 member 2

decreases expression

EXP

Norepinephrine results in decreased expression of SLC14A2 protein

Ensembl chr18:73,887,575...73,953,570

G

solute carrier family 18 member A1

multiple interactions

ISO

Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]

NCBI chr16:25,408,485...25,453,786
Ensembl chr16:25,420,243...25,453,786

G

solute carrier family 18 member A2

multiple interactions
increases expression
decreases activity
affects binding

EXP
ISO

Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]
Norepinephrine results in increased expression of SLC18A2 mRNA
Norepinephrine results in decreased activity of SLC18A2 protein
Norepinephrine binds to SLC18A2 protein

PMID:1438304 PMID:7912402 PMID:14618266 PMID:15475732

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 22 member 3

increases uptake
multiple interactions

ISO
EXP

SLC22A3 protein results in increased uptake of Norepinephrine
Norepinephrine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]

PMID:9830022 PMID:20858707

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 29 member 4

increases uptake

ISO

SLC29A4 protein results in increased uptake of Norepinephrine

NCBI chr12:16,967,047...16,998,276
Ensembl chr12:16,967,047...16,988,338

G

solute carrier family 6 member 2

multiple interactions
increases uptake
decreases expression
decreases uptake
decreases activity

ISO
EXP

N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A2 protein results in increased uptake of Norepinephrine]; Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein]; SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]
[Cullen corylifolium extract results in decreased activity of SLC6A2 protein] which results in decreased uptake of Norepinephrine; Norepinephrine affects the localization of and affects the metabolism of SLC6A2 protein
[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]
Norepinephrine results in decreased expression of SLC6A2 protein
SLC6A2 mutant form results in decreased uptake of Norepinephrine
Norepinephrine results in decreased activity of SLC6A2 protein

PMID:11082428 PMID:11458707 PMID:16338971 PMID:16725121 PMID:17234900 More...

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

solute carrier family 6 member 3

multiple interactions
increases uptake

ISO

SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]
SLC6A3 protein results in increased uptake of Norepinephrine

PMID:17234900 PMID:17250655

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

multiple interactions

ISO

SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier family 8 member A1

increases expression

EXP

Norepinephrine results in increased expression of SLC8A1 mRNA; Norepinephrine results in increased expression of SLC8A1 protein

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964

G

superoxide dismutase 2

decreases expression
increases expression
multiple interactions

EXP
ISO

Norepinephrine results in decreased expression of SOD2 protein
Norepinephrine results in increased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]
SHC1 protein affects the reaction [Norepinephrine results in decreased expression of SOD2 protein]

PMID:19168439 PMID:23114885

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

steroidogenic acute regulatory protein

increases expression

EXP

Norepinephrine results in increased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

ISO

[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]; Carnosine inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

spleen associated tyrosine kinase

increases expression

EXP

Norepinephrine results in increased expression of SYK mRNA

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278

G

trace-amine-associated receptor 1

multiple interactions

ISO

SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]

NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981

G

thromboxane A2 receptor

multiple interactions

EXP

[SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to Norepinephrine

NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905

G

transcription factor A, mitochondrial

multiple interactions

EXP

[Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNA; [Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNA

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transforming growth factor, beta 1

multiple interactions
increases expression

EXP

Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB1 mRNA]

PMID:15326086 PMID:19575289

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

increases expression
multiple interactions

EXP

Norepinephrine results in increased expression of TGFB2 mRNA; Norepinephrine results in increased expression of TGFB2 protein
Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA]

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

increases expression
multiple interactions

EXP

Norepinephrine results in increased expression of TGFB3 mRNA
Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA]

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

tyrosine hydroxylase

multiple interactions
increases chemical synthesis

EXP
ISO

[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine
TH protein results in increased chemical synthesis of Norepinephrine

PMID:9822156 PMID:19067675

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

Thy-1 cell surface antigen

decreases expression
multiple interactions

ISO

Norepinephrine results in decreased expression of THY1
Propranolol inhibits the reaction [Norepinephrine results in decreased expression of THY1]

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

translocase of inner mitochondrial membrane 13

increases expression

EXP

Norepinephrine results in increased expression of TIMM13 mRNA

NCBI chr 7:9,459,490...9,460,849
Ensembl chr 7:9,459,582...9,460,862

G

TIMP metallopeptidase inhibitor 2

increases expression
multiple interactions

EXP

Norepinephrine results in increased expression of TIMP2 mRNA
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]

PMID:14577597 PMID:15326086

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

tumor necrosis factor

multiple interactions
increases expression
increases secretion

EXP

Acetylcysteine inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Norepinephrine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]
Norepinephrine results in increased expression of TNF mRNA

PMID:8392517 PMID:15081246 PMID:15158148 PMID:25437044

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases expression

EXP

Norepinephrine results in increased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

uncoupling protein 1

multiple interactions
increases expression

ISO
EXP

[Rosiglitazone results in increased susceptibility to Norepinephrine] which results in increased expression of UCP1 mRNA; [Rosiglitazone results in increased susceptibility to Norepinephrine] which results in increased expression of UCP1 protein; AG 1879 promotes the reaction [Norepinephrine results in increased expression of UCP1 mRNA]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA

PMID:10465291 PMID:10788502 PMID:11742803 PMID:29910772 PMID:31048375

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

uncoupling protein 2

increases expression

EXP

Norepinephrine results in increased expression of UCP2 mRNA

PMID:8593794 PMID:12588052

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

upstream transcription factor 1

multiple interactions

ISO

USF1 gene polymorphism promotes the reaction [Norepinephrine results in increased metabolism of Lipids]; USF1 protein affects the reaction [Norepinephrine results in increased metabolism of Lipids]

NCBI chr13:86,377,679...86,385,523
Ensembl chr13:86,377,717...86,385,522

G

vitamin D receptor

increases abundance

ISO

VDR protein results in increased abundance of Norepinephrine

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

vascular endothelial growth factor A

multiple interactions
increases expression

ISO

[Cobalt co-treated with Norepinephrine] results in increased expression of VEGFA mRNA; [Cycloheximide co-treated with Norepinephrine] results in increased expression of VEGFA mRNA; [Norepinephrine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA mRNA; AG 1879 inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; Cyclic AMP affects the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

X-box binding protein 1

affects localization

EXP

Norepinephrine affects the localization of XBP1 protein

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

xanthine dehydrogenase

increases expression

EXP

Norepinephrine results in increased expression of XDH mRNA

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

8-epi-prostaglandin E2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

prostaglandin E receptor 4

affects response to substance

ISO

PTGER4 protein affects the susceptibility to 8-isoprostaglandin E2

NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135

8-epi-prostaglandin F2alpha

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein E

multiple interactions

ISO

[APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amyloid beta precursor protein

multiple interactions
increases abundance

ISO

[Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

interleukin 1 beta

multiple interactions
increases abundance
increases chemical synthesis

ISO
EXP

1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]

PMID:11530235 PMID:16529823 PMID:19751497

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

platelet-activating factor acetylhydrolase 2

affects metabolic processing
multiple interactions

ISO

PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]

NCBI chr 5:151,890,751...151,919,896
Ensembl chr 5:151,896,832...151,919,894

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

[L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

thromboxane A2 receptor

multiple interactions
affects response to substance

ISO

8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha

PMID:18158556 PMID:22565502

NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

serpin family F member 1

multiple interactions

ISO

epinephrine promotes the reaction [lipopolysaccharide increases expression of Serpinf1 protein in plasma]

RGD

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases methylation
increases metabolic processing
increases hydroxylation

ISO

CYP1A1 protein results in decreased methylation of almotriptan
CYP1A1 protein results in increased metabolism of almotriptan
CYP1A1 protein results in increased hydroxylation of almotriptan

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases methylation

ISO

CYP1A2 protein results in decreased methylation of almotriptan

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases methylation

ISO

CYP2C19 protein results in decreased methylation of almotriptan

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases methylation

ISO

CYP2C8 protein results in decreased methylation of almotriptan

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases methylation
increases hydroxylation

ISO

CYP2D6 protein results in decreased methylation of almotriptan
CYP2D6 protein results in increased hydroxylation of almotriptan

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation
decreases methylation

ISO

CYP3A4 protein results in increased hydroxylation of almotriptan
CYP3A4 protein results in decreased methylation of almotriptan

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

flavin containing dimethylaniline monoxygenase 3

increases oxidation

ISO

FMO3 protein results in increased oxidation of almotriptan

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256

G

5-hydroxytryptamine receptor 1B

multiple interactions

ISO

HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583

G

monoamine oxidase A

increases metabolic processing

ISO

MAOA protein results in increased metabolism of almotriptan

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

affects abundance

ISO

[ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

EXP

Spironolactone inhibits the reaction [Angiotensin II results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of ACTA2 protein]
Angiotensin II results in increased expression of ACTA2 mRNA; Angiotensin II results in increased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

angiotensinogen

multiple interactions

ISO

[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

increases expression

EXP

Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bone morphogenetic protein 2

increases expression

ISO

angiotensin II increases expression of mRNA in mouse heart

RGD

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

bone morphogenetic protein 4

increases expression

ISO

angiotensin II increases expression of mRNA in mouse heart

RGD

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

collagen type I alpha 1 chain

multiple interactions
increases expression

ISO
EXP

NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]

PMID:33746155 PMID:39218321

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

increases expression
multiple interactions

ISO
EXP

Angiotensin II results in increased expression of COL3A1 mRNA
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of COL3A1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of COL3A1 mRNA]

PMID:33746155 PMID:39218321

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

carnitine palmitoyltransferase 1A

multiple interactions
decreases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

endothelin receptor type B

increases expression

EXP

Angiotensin II results in increased expression of EDNRB protein

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

estrogen related receptor, alpha

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of ESRRA protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

fission, mitochondrial 1

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

heme oxygenase 1

multiple interactions
decreases expression

EXP

Spironolactone inhibits the reaction [Angiotensin II results in decreased expression of HMOX1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in decreased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

inhibitor of DNA binding 1

increases expression

ISO

angiotensin II increases expression of mRNA in mouse heart

RGD

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

interleukin 1 beta

increases expression
multiple interactions

ISO

Angiotensin II results in increased expression of IL1B mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Janus kinase 2

increases phosphorylation

ISO

Angiotensin II increases phosphorylation of JAK2 protein in liver

RGD

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

KLF transcription factor 4

increases expression

ISO

angiotensin II increases expression of KLF4 mRNA and protein in vascular smooth muscle cells

RGD

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

mitogen activated protein kinase kinase kinase 7

increases expression

ISO

Angiotensin II increases expression of MAP3K7 mRNA in cardiomyocytes

RGD

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

ISO

Angiotensin II results in decreased expression of MCL1 protein
naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein]

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

microRNA 143

decreases expression

ISO

Angiotensin II decreases expression of miRNA143 RNA in vascular smooth muscle cells

RGD

NCBI chr18:57,371,349...57,371,453

G

microRNA 145

decreases expression

ISO

angiotensin II decreases expression of MIR145a RNA in vascular smooth muscle cell
Angiotensin II decreases expression of miRNA145 RNA in vascular smooth muscle cells

RGD

PMID:29127880 PMID:28167124

RGD:155230825, RGD:155260287

NCBI chr18:57,369,983...57,370,070

G

matrix metallopeptidase 2

increases expression
multiple interactions

EXP

Angiotensin II results in increased expression of MMP2 mRNA
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of MMP2 mRNA]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

myosin heavy chain 6

multiple interactions
decreases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form]

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myocardin

decreases expression

ISO

angiotensin II decreases expression of MYOCD mRNA and protein in vascular smooth muscle cell

RGD

NCBI chr10:50,332,356...50,426,819
Ensembl chr10:50,332,356...50,426,819

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

ISO
EXP

NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]
Angiotensin II results in decreased expression of NFE2L2 mRNA
Spironolactone inhibits the reaction [Angiotensin II results in decreased expression of NFE2L2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in decreased expression of NFE2L2 mRNA]

PMID:33746155 PMID:39218321

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NADPH oxidase 4

multiple interactions
increases expression

ISO

NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]
Angiotensin II results in increased expression of NOX4 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]

PMID:33746155 PMID:38230784

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

NPHS1 adhesion molecule, nephrin

multiple interactions

ISO

angiotensin II inhibits reaction [fluvastatin increases expression of Nphs1 protein in kidney]

RGD

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521

G

natriuretic peptide A

increases expression
multiple interactions

ISO
EXP

angiotensin II increases expression of mRNA in mouse heart
Angiotensin II results in increased expression of NPPA mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA]

CTD
RGD

PMID:37269933 PMID:26873969

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

increases expression
multiple interactions

ISO
EXP

angiotensin II increases expression of mRNA in mouse heart
Angiotensin II results in increased expression of NPPB mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA]

CTD
RGD

PMID:37269933 PMID:26873969

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

nuclear receptor subfamily 1, group H, member 3

increases expression

ISO

Angiotensin II decreases expression of NR1H3 mRNA and protein in macrophages

RGD

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group I, member 2

affects response to substance

ISO

NR1I2 protein affects the susceptibility to Angiotensin II

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

pyruvate dehydrogenase E1 subunit alpha 1

multiple interactions
decreases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:38,509,084...38,522,536

G

phosphofructokinase, muscle

increases expression
multiple interactions

EXP

Angiotensin II results in increased expression of PFKM mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]]

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

periostin

increases expression

ISO

Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP

PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

PPARG coactivator 1 beta

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of PPARGC1B protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein]

NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466

G

protein kinase D1

affects localization

EXP

Angiotensin II affects localization of Prkd1 protein in cardiomyocytes

RGD

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

protein tyrosine phosphatase, non-receptor type 1

increases expression

EXP

Angiotensin II increases expression of Ptpn1 protein in cardiac microvascular endothelial cells

RGD

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

G

RNA binding fox-1 homolog 2

decreases expression

EXP

Angiotensin II decreases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells

RGD

NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:110,691,230...110,934,987

G

SRY-box transcription factor 17

increases expression
decreases expression

ISO

Angiotensin II increases expression of SOX17 mRNA and protein in retinal microvascular endothelial cells
Angiotensin II decreases expression of SOX17 protein in retinal endothelial cells

RGD

PMID:36200131 PMID:32078435

RGD:329853320, RGD:329853329

NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854

G

secreted phosphoprotein 1

increases expression

ISO

Angiotensin II increases expression of Spp1 protein in vascular smooth muscle cells

RGD

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

transcription factor A, mitochondrial

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transforming growth factor, beta 1

multiple interactions
increases expression

EXP

Spironolactone inhibits the reaction [Angiotensin II results in increased expression of TGFB1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

increases expression
multiple interactions

ISO

Angiotensin II results in increased expression of TNF mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor associated factor 6

increases expression

EXP

Angiotensin II increases expression of Traf6 protein in rat neonatal cardiomyocytes

RGD

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

zinc finger E-box binding homeobox 2

decreases expression

EXP

Angiotensin II decreases expression of Zeb2 mRNA and protein in rat renal artery endothelial cells

RGD

NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:49,624,028...49,754,323

caesium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

multiple interactions

ISO

cesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

vascular endothelial growth factor A

multiple interactions

ISO

cesium chloride inhibits the reaction [Acrolein results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

carbocyclic thromboxane A2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

TNF receptor superfamily member 11B

decreases expression

ISO

thromboxane A2, carbocyclic results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF superfamily member 11

increases expression

ISO

thromboxane A2, carbocyclic results in increased expression of TNFSF11 mRNA

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin-like 1

decreases expression

EXP

Cocaine results in decreased expression of A2ML1 mRNA

NCBI chr 4:163,501,210...163,543,419
Ensembl chr 4:163,501,585...163,543,506

G

acetoacetyl-CoA synthetase

affects expression

EXP

Cocaine affects the expression of AACS mRNA

NCBI chr12:36,774,471...36,817,835
Ensembl chr12:36,774,471...36,822,543

G

arylacetamide deacetylase

decreases expression

EXP

Cocaine results in decreased expression of AADAC mRNA

NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525

G

aralkylamine N-acetyltransferase

affects response to substance

ISO

AANAT protein affects the susceptibility to Cocaine

NCBI chr10:102,323,647...102,330,639
Ensembl chr10:102,326,135...102,330,635

G

4-aminobutyrate aminotransferase

increases response to substance

ISO

ABAT mRNA results in increased susceptibility to Cocaine

NCBI chr10:7,503,351...7,599,474
Ensembl chr10:7,492,022...7,599,474

G

ATP binding cassette subfamily A member 4

decreases expression

EXP

Cocaine results in decreased expression of ABCA4 mRNA

NCBI chr 2:212,849,470...212,986,730
Ensembl chr 2:212,755,803...212,986,729

G

ATP binding cassette subfamily A member 5

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of ABCA5 mRNA]

NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,739,610...95,808,424

G

ATP binding cassette subfamily C member 3

affects expression

EXP

Cocaine affects the expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 5

affects expression

EXP

Cocaine affects the expression of ABCC5 mRNA

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

ATP binding cassette subfamily C member 9

affects expression

EXP

Cocaine affects the expression of ABCC9 mRNA

NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348

G

ATP binding cassette subfamily D member 4

affects expression

EXP

Cocaine affects the expression of ABCD4 mRNA

NCBI chr 6:109,977,541...109,992,050
Ensembl chr 6:109,977,550...109,991,983

G

abhydrolase domain containing 1

decreases expression

ISO

Cocaine results in decreased expression of ABHD1 mRNA

NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:31,142,476...31,147,464

G

abhydrolase domain containing 14A

affects expression

EXP

Cocaine affects the expression of ABHD14A mRNA

NCBI chr 8:115,957,853...115,965,697
Ensembl chr 8:115,957,858...115,965,697

G

abhydrolase domain containing 17A, depalmitoylase

affects expression

EXP

Cocaine affects the expression of ABHD17A mRNA

NCBI chr 7:9,775,016...9,781,447

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

affects expression

ISO

Cocaine affects the expression of ABL1 mRNA

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

acetyl-Coenzyme A acyltransferase 1B

increases expression

ISO

Cocaine results in increased expression of ACAA1 mRNA

NCBI chr 8:127,750,771...127,759,589
Ensembl chr 8:127,750,743...127,759,569

G

aggrecan

affects expression

EXP

Cocaine affects the expression of ACAN mRNA

NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779

G

angiotensin I converting enzyme

multiple interactions

ISO

ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone]; ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol]

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

apoptotic chromatin condensation inducer 1

affects expression

ISO

Cocaine affects the expression of ACIN1 mRNA

NCBI chr15:32,072,121...32,117,004
Ensembl chr15:32,072,123...32,117,166

G

atypical chemokine receptor 2

affects expression

EXP

Cocaine affects the expression of ACKR2 mRNA

NCBI chr 8:130,438,703...130,451,106
Ensembl chr 8:130,384,559...130,464,393

G

aconitase 2

increases expression

ISO

Cocaine results in increased expression of ACO2 protein modified form

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

aconitate decarboxylase 1

EXP

[cocaine cotreated with recombinant HIV Tat protein] increases expression of Acod1 mRNA in primary motor cortex neuronal cultures

RGD

NCBI chr15:86,286,531...86,295,803
Ensembl chr15:86,286,579...86,295,687

G

acyl-CoA synthetase long-chain family member 5

affects expression

EXP

Cocaine affects the expression of ACSL5 mRNA

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943

G

acyl-CoA synthetase short-chain family member 1

decreases expression

EXP

Cocaine results in decreased expression of ACSS1 mRNA

NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748

G

actin gamma 2, smooth muscle

decreases expression

ISO

Cocaine results in decreased expression of ACTG2 mRNA

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:117,579,514...117,604,295

G

actinin alpha 2

increases expression

ISO

Cocaine results in increased expression of ACTN2 mRNA

PMID:15009677 PMID:16710320

NCBI chr17:62,835,055...62,902,331
Ensembl chr17:62,812,988...62,903,552

G

activin A receptor type 1C

increases expression

EXP

Cocaine results in increased expression of ACVR1C mRNA

NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:63,227,559...63,301,205

G

aminoacylase 3

affects expression

EXP

Cocaine affects the expression of ACY3 mRNA

NCBI chr 1:210,709,238...210,715,258
Ensembl chr 1:210,709,294...210,715,633

G

ADAM metallopeptidase domain 19

decreases expression

EXP

Cocaine results in decreased expression of ADAM19 mRNA

NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455

G

ADAM metallopeptidase domain 1a

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of ADAM1A mRNA]

NCBI chr12:40,674,460...40,680,988
Ensembl chr12:40,676,918...40,684,619

G

ADAM metallopeptidase with thrombospondin type 1 motif, 19

decreases expression

EXP

Cocaine results in decreased expression of ADAMTS19 mRNA

NCBI chr18:54,545,357...54,729,184
Ensembl chr18:54,545,357...54,729,181

G

adenosine deaminase, tRNA-specific 2

decreases expression

EXP

Cocaine results in decreased expression of ADAT2 mRNA

NCBI chr 1:9,774,680...9,795,376
Ensembl chr 1:9,774,680...9,795,376

G

adenylate cyclase 2

affects expression

EXP

Cocaine affects the expression of ADCY2 mRNA

NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645

G

adenylate cyclase 8

affects expression

EXP

Cocaine affects the expression of ADCY8 mRNA

NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:98,306,464...98,555,038

G

adenylate cyclase activating polypeptide 1

increases expression
multiple interactions

ISO

Cocaine results in increased expression of ADCYAP1 mRNA
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; ADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]

NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:120,550,328...120,556,383

G

ADCYAP receptor type I

increases expression
multiple interactions

ISO

Cocaine results in increased expression of ADCYAP1R1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]

NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:85,924,100...85,972,973

G

adhesion G protein-coupled receptor A1

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of ADGRA1 mRNA

NCBI chr 1:204,059,218...204,102,869
Ensembl chr 1:204,059,367...204,102,869

G

adhesion G protein-coupled receptor E1

affects expression

EXP

Cocaine affects the expression of ADGRE1 mRNA

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

adhesion G protein-coupled receptor F1

decreases expression

EXP

Cocaine results in decreased expression of ADGRF1 mRNA

NCBI chr 9:25,158,198...25,210,744
Ensembl chr 9:25,147,588...25,208,916

G

adhesion G protein-coupled receptor L1

affects expression

EXP

Cocaine affects the expression of ADGRL1 mRNA

NCBI chr19:41,107,162...41,148,752
Ensembl chr19:41,109,117...41,148,896

G

adhesion G protein-coupled receptor L3

affects expression

EXP

Cocaine affects the expression of ADGRL3 mRNA

NCBI chr14:26,690,891...27,458,132
Ensembl chr14:26,722,194...27,280,418

G

adenosine A1 receptor

affects expression
affects response to substance

EXP
ISO

Cocaine affects the expression of ADORA1 mRNA; Cocaine affects the expression of ADORA1 protein
ADORA1 affects the susceptibility to Cocaine

PMID:12358776 PMID:19092996

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190

G

adenosine A2a receptor

increases response to substance
increases expression

ISO

ADORA2A results in increased susceptibility to Cocaine
Cocaine deficiency results in increased expression of ADORA2A mRNA

PMID:16123743 PMID:27126842

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adenosine A2B receptor

affects expression

EXP

Cocaine affects the expression of ADORA2B mRNA

NCBI chr10:47,439,712...47,456,092
Ensembl chr10:47,439,701...47,456,091

G

adrenoceptor alpha 1B

increases response to substance

ISO

ADRA1B gene results in increased susceptibility to Cocaine

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor beta 1

multiple interactions
affects expression

EXP

Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]

PMID:17513029 PMID:18596687

NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237

G

ALF transcription elongation factor 4

increases expression

EXP

Cocaine results in increased expression of AFF4 mRNA

NCBI chr10:37,998,319...38,080,580
Ensembl chr10:37,999,579...38,080,580

G

arylformamidase

increases expression

EXP

Cocaine results in increased expression of AFMID mRNA

NCBI chr10:103,544,822...103,560,408
Ensembl chr10:103,544,841...103,560,408

G

alpha-fetoprotein

increases expression

EXP

Cocaine results in increased expression of AFP mRNA

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

affects expression

EXP

Cocaine affects the expression of AGAP2 mRNA

NCBI chr 7:64,782,618...64,799,624
Ensembl chr 7:64,782,612...64,799,640

G

argonaute RISC catalytic component 2

multiple interactions
affects response to substance

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR130A mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR136 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR137 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR138-1 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR148B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR154 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR181A1 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR186 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR301B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR324 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR337 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR369 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376A mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376C mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR380 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR384 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR467B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR500 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR544 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]
AGO2 protein affects the susceptibility to Cocaine

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

allograft inflammatory factor 1-like

decreases expression

ISO

Cocaine results in decreased expression of AIF1L mRNA

NCBI chr 3:35,627,239...35,651,793
Ensembl chr 3:35,627,239...35,651,793

G

apoptosis inducing factor, mitochondria associated 1

affects expression
increases expression

ISO

Cocaine affects the expression of AIFM1 mRNA
Cocaine results in increased expression of AIFM1 mRNA

PMID:15681117 PMID:18000554

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

AIF family member 2

affects expression

ISO

Cocaine affects the expression of AIFM2 mRNA

NCBI chr20:30,195,781...30,222,014
Ensembl chr20:30,193,829...30,220,957

G

adenylate kinase 1

decreases expression

ISO

Cocaine results in decreased expression of AK1 mRNA

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

adenylate kinase 3

affects expression

EXP

Cocaine affects the expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

aldo-keto reductase family 1, member D1

affects expression

EXP

Cocaine affects the expression of AKR1D1 mRNA

NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540

G

aldo-keto reductase family 1, member E2

affects expression

EXP

Cocaine affects the expression of AKR1E1 mRNA

NCBI chr17:70,645,835...70,660,366
Ensembl chr17:70,645,869...70,660,360

G

aldo-keto reductase family 7 member A3

affects expression

EXP

Cocaine affects the expression of AKR7A3 mRNA

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

AKT serine/threonine kinase 1

affects expression
multiple interactions
increases phosphorylation

EXP
ISO

Cocaine affects the expression of AKT1 mRNA
[Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of AKT1 protein
Cocaine results in increased phosphorylation of AKT1 protein
Cocaine affects the reaction [ILK protein affects the phosphorylation of AKT1 protein]

PMID:18702665 PMID:20187946 PMID:25933444

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

activated leukocyte cell adhesion molecule

increases expression

EXP

Cocaine results in increased expression of ALCAM mRNA

NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876

G

aldehyde dehydrogenase 2 family member

multiple interactions

EXP

[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine; ALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine]

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

autophagy and beclin 1 regulator 1

decreases expression

EXP

Cocaine results in decreased expression of AMBRA1 mRNA

NCBI chr 3:98,156,626...98,345,876
Ensembl chr 3:98,156,652...98,345,872

G

anti-Mullerian hormone

increases expression

EXP

Cocaine results in increased expression of AMH mRNA

NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867

G

adhesion molecule with Ig like domain 1

affects expression

EXP

Cocaine affects the expression of AMIGO1 mRNA

NCBI chr 2:198,511,285...198,516,744
Ensembl chr 2:198,511,039...198,521,146

G

adhesion molecule with Ig like domain 3

affects expression

EXP

Cocaine affects the expression of AMIGO3 mRNA

NCBI chr 8:117,620,499...117,622,025
Ensembl chr 8:117,616,629...117,626,577

G

antagonist of mitotic exit network 1 homolog

decreases expression

EXP

Cocaine results in decreased expression of AMN1 mRNA

NCBI chr 4:183,886,469...183,913,411
Ensembl chr 4:183,886,474...183,913,411

G

ankyrin repeat domain 54

affects expression

EXP

Cocaine affects the expression of ANKRD54 mRNA

NCBI chr 7:112,495,396...112,508,186
Ensembl chr 7:112,495,462...112,508,128

G

ankyrin repeat and sterile alpha motif domain containing 1B

decreases expression

EXP

Cocaine results in decreased expression of ANKS1B mRNA

NCBI chr 7:26,200,649...27,366,552
Ensembl chr 7:26,201,240...27,364,943

G

annexin A7

affects expression

EXP

Cocaine affects the expression of ANXA7 mRNA

NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,870,974...3,898,891

G

adaptor-related protein complex 1 associated regulatory protein

increases expression

EXP

Cocaine results in increased expression of AP1AR mRNA

NCBI chr 2:218,951,104...218,983,495
Ensembl chr 2:218,927,373...218,983,752

G

adaptor related protein complex 2 subunit beta 1

affects expression

EXP

Cocaine affects the expression of AP2B1 mRNA

NCBI chr10:68,596,925...68,702,547
Ensembl chr10:68,597,093...68,702,539

G

adaptor related protein complex 2 subunit mu 1

increases expression

EXP

Cocaine results in increased expression of AP2M1 protein

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:93,859,690...93,868,480

G

adaptor related protein complex 2 subunit sigma 1

decreases expression

ISO

Cocaine results in decreased expression of AP2S1 mRNA

NCBI chr 1:86,545,601...86,557,007
Ensembl chr 1:86,545,350...86,557,009

G

adaptor related protein complex 5 subunit mu 1

affects expression

EXP

Cocaine affects the expression of AP5M1 mRNA

NCBI chr15:24,835,122...24,864,854
Ensembl chr15:24,835,100...24,862,606

G

amyloid P component, serum

increases expression

ISO

Cocaine results in increased expression of APCS protein

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

aph-1 homolog A, gamma secretase subunit

affects expression

EXP

Cocaine affects the expression of APH1A mRNA

NCBI chr 2:186,123,023...186,130,886
Ensembl chr 2:186,127,323...186,132,045

G

apelin receptor

increases expression

EXP

Cocaine results in increased expression of APLNR mRNA

NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:90,624,012...90,627,908

G

apolipoprotein L11a

decreases expression

EXP

Cocaine results in decreased expression of APOL11A mRNA

NCBI chr 7:111,118,668...111,142,866

G

apolipoprotein L2

increases expression

ISO

Cocaine results in increased expression of APOL2 mRNA

NCBI chr 7:111,211,944...111,219,209
Ensembl chr 7:111,211,893...111,217,223

G

apolipoprotein L domain containing 1

affects expression

EXP

Cocaine affects the expression of APOLD1 mRNA

NCBI chr 4:169,499,728...169,557,075
Ensembl chr 4:169,549,679...169,559,176

G

apolipoprotein O

increases expression

EXP

Cocaine results in increased expression of APOO protein

NCBI chr X:63,151,736...63,256,696
Ensembl chr X:63,151,814...63,256,690

G

amyloid beta precursor protein

decreases expression
increases expression

EXP
ISO

Cocaine results in decreased expression of APP mRNA
Cocaine results in increased expression of APP mRNA

PMID:15009677 PMID:16710320 PMID:17898221

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

increases expression

EXP

Cocaine results in increased expression of APPL1 mRNA

NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,125,234...2,173,421

G

activity-regulated cytoskeleton-associated protein

affects expression
multiple interactions
increases expression

EXP
ISO

Cocaine affects the expression of ARC mRNA
cocaine co treated with anisomycin decreases expression of Arc protein in dorsal striatum and shell of nucleus accumbens
Cocaine increases expression of Arc protein in dorsal striatum and shell of nucleus accumbens
Cocaine results in increased expression of ARC mRNA; Cocaine results in increased expression of ARC protein
Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA]

CTD
RGD

PMID:7722525 PMID:12117546 PMID:15254092 PMID:17851536 PMID:18311559 More...

RGD:401901591, RGD:401901591

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

ARF GTPase 4

decreases expression

EXP

Cocaine results in decreased expression of ARF4 protein

NCBI chr16:1,903,238...1,920,012
Ensembl chr16:1,903,371...1,920,011

G

Rho GTPase activating protein 1

increases expression

EXP

Cocaine results in increased expression of ARHGAP1 protein

NCBI chr 3:98,077,064...98,099,163
Ensembl chr 3:98,077,150...98,099,154

G

Rho GTPase activating protein 29

decreases expression

ISO

Cocaine results in decreased expression of ARHGAP29 mRNA

NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:212,755,803...212,986,729

G

Rho GTPase activating protein 30

increases expression

EXP

Cocaine results in increased expression of ARHGAP30 mRNA

NCBI chr13:86,354,448...86,376,552
Ensembl chr13:86,354,547...86,376,888

G

Rho GTPase activating protein 44

decreases expression

EXP

Cocaine results in decreased expression of ARHGAP44 protein

NCBI chr10:50,154,724...50,322,027
Ensembl chr10:50,154,724...50,321,897

G

Rho GTPase activating protein 5

increases expression

EXP

Cocaine results in increased expression of ARHGAP5 mRNA

NCBI chr 6:75,711,199...75,774,636
Ensembl chr 6:75,711,515...75,774,636

G

Rho GTPase activating protein 9

decreases expression

EXP

Cocaine results in decreased expression of ARHGAP9 mRNA

NCBI chr 7:65,034,023...65,042,336
Ensembl chr 7:65,034,144...65,042,336

G

Rho guanine nucleotide exchange factor 1

affects expression

EXP

Cocaine affects the expression of ARHGEF1 mRNA

NCBI chr 1:89,626,884...89,648,823
Ensembl chr 1:89,628,266...89,649,067

G

Rho guanine nucleotide exchange factor 7

affects expression

EXP

Cocaine affects the expression of ARHGEF7 mRNA

NCBI chr16:84,373,123...84,484,759
Ensembl chr16:84,373,123...84,484,597

G

armadillo repeat containing, X-linked 6

affects expression

EXP

Cocaine affects the expression of ARMCX6 mRNA

NCBI chr X:102,222,288...102,229,871
Ensembl chr X:102,222,220...102,240,052

G

actin related protein 2/3 complex, subunit 1A

increases expression

EXP

Cocaine results in increased expression of ARPC1A protein

NCBI chr12:14,616,245...14,639,052
Ensembl chr12:14,616,248...14,639,052

G

cAMP-regulated phosphoprotein 19

multiple interactions

EXP

Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP19 protein]

NCBI chr 8:84,660,166...84,683,012
Ensembl chr 8:119,691,942...119,692,385
Ensembl chr 8:119,691,942...119,692,385

G

cAMP regulated phosphoprotein 21

multiple interactions
increases expression

EXP
ISO

Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP21 protein]
Cocaine deficiency results in increased expression of ARPP21 mRNA

PMID:11268215 PMID:27126842

NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:120,912,970...121,031,357

G

ADP-ribosyltransferase 5

increases expression

EXP

Cocaine results in increased expression of ART5 mRNA

NCBI chr 1:165,885,344...165,895,306
Ensembl chr 1:165,885,280...165,895,306

G

arsenite methyltransferase

affects expression

EXP

Cocaine affects the expression of AS3MT mRNA

NCBI chr 1:255,536,879...255,569,245
Ensembl chr 1:255,537,109...255,569,249

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

decreases expression

EXP

Cocaine results in decreased expression of ASAP1 mRNA

NCBI chr 7:97,675,354...97,982,523
Ensembl chr 7:97,675,354...97,982,024

G

ATPase family, AAA domain containing 1

increases expression

EXP

Cocaine results in increased expression of ATAD1 mRNA

NCBI chr 1:239,957,329...240,023,792
Ensembl chr 1:239,957,882...240,009,822

G

ATPase family, AAA domain containing 5

decreases expression

EXP

Cocaine results in decreased expression of ATAD5 mRNA

NCBI chr10:65,568,569...65,616,379
Ensembl chr10:65,568,591...65,616,376

G

arginyltransferase 1

increases expression

EXP

Cocaine results in increased expression of ATE1 mRNA

NCBI chr 1:194,391,843...194,514,284
Ensembl chr 1:194,391,843...194,511,348

G

activating transcription factor 3

increases expression
decreases expression

EXP

Cocaine results in increased expression of ATF3 mRNA
Cocaine results in decreased expression of ATF3 mRNA

PMID:23644055 PMID:27899881

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

increases expression

EXP

Cocaine results in increased expression of ATF4; Cocaine results in increased expression of ATF4 mRNA

PMID:18593214 PMID:23644055

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 6

affects expression

EXP

Cocaine affects the expression of ATF6 mRNA

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

activating transcription factor 7

affects expression

ISO

Cocaine affects the expression of ATF7 mRNA

NCBI chr 7:135,537,351...135,649,188
Ensembl chr 7:135,542,111...135,599,899

G

autophagy related 2B

affects expression

EXP

Cocaine affects the expression of ATG2B mRNA

NCBI chr 6:130,286,979...130,357,109
Ensembl chr 6:130,286,986...130,357,109

G

autophagy related 4B, cysteine peptidase

affects expression

EXP

Cocaine affects the expression of ATG4B mRNA

NCBI chr 9:101,729,772...101,761,456
Ensembl chr 9:101,726,782...101,761,622

G

ATM serine/threonine kinase

multiple interactions
increases expression

ISO

EHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase phospholipid transporting 10A (putative)

decreases expression

EXP

Cocaine results in decreased expression of ATP10A mRNA

PMID:17898221 PMID:27899881

NCBI chr 1:118,692,456...118,866,117
Ensembl chr 1:118,692,478...118,866,114

G

ATPase Na+/K+ transporting subunit alpha 1

affects expression

ISO

Cocaine affects the expression of ATP1A1 mRNA

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
affects expression

EXP

Cocaine results in increased expression of ATP1A3 mRNA
Cocaine affects the expression of ATP1A3 mRNA

PMID:16076954 PMID:20187946

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825

G

ATPase Na+/K+ transporting subunit beta 2

increases expression

EXP

Cocaine results in increased expression of ATP1B2 mRNA

NCBI chr10:54,817,473...54,823,708
Ensembl chr10:54,817,476...54,823,708

G

ATPase Na+/K+ transporting subunit beta 3

increases expression
multiple interactions

ISO

Cocaine results in increased expression of ATP1B3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP1B3 mRNA]

NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:65,253,361...65,254,304
Ensembl chr 8:65,253,361...65,254,304

G

ATP synthase F1 subunit alpha

affects expression

ISO

Cocaine affects the expression of ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATP synthase F1 subunit beta

decreases expression

ISO

Cocaine results in decreased expression of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase F1 subunit epsilon

affects expression

EXP

Cocaine affects the expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214

G

ATP synthase membrane subunit c locus 3

decreases expression
affects expression

ISO
EXP

Cocaine results in decreased expression of ATP5MC3 mRNA
Cocaine affects the expression of ATP5MC3 mRNA

PMID:12629581 PMID:20187946

NCBI chr 3:79,218,014...79,220,664
Ensembl chr 3:79,218,014...79,220,664

G

ATP synthase peripheral stalk-membrane subunit b

affects expression

EXP

Cocaine affects the expression of ATP5PB mRNA

NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387

G

ATP synthase peripheral stalk subunit d

affects expression

EXP

Cocaine affects the expression of ATP5PD mRNA

NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954

G

ATPase H+ transporting V1 subunit D

affects expression

EXP

Cocaine affects the expression of ATP6V1D mRNA

NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:103,389,783...103,405,346

G

ATPase phospholipid transporting 8B2

increases expression
multiple interactions

ISO

Cocaine results in increased expression of ATP8B2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP8B2 mRNA]

NCBI chr 2:177,676,205...177,699,575
Ensembl chr 2:177,676,208...177,699,575

G

ATPase phospholipid transporting 9B (putative)

affects response to substance

ISO

ATP9B gene SNP affects the susceptibility to Cocaine

NCBI chr18:76,451,821...76,643,931
Ensembl chr18:76,451,821...76,643,893

G

ATP synthase mitochondrial F1 complex assembly factor 1

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ATPAF1 mRNA

NCBI chr 5:134,503,164...134,530,323
Ensembl chr 5:134,499,687...134,530,321

G

ATRX, chromatin remodeler

increases expression

EXP

Cocaine results in increased expression of ATRX mRNA

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:74,916,548...75,062,880

G

ataxin 1

affects expression

EXP

Cocaine affects the expression of ATXN1 mRNA

NCBI chr17:18,943,397...19,354,751
Ensembl chr17:19,208,200...19,356,790

G

ataxin 3

decreases expression

ISO

Cocaine results in decreased expression of ATXN3 mRNA

NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:126,839,327...126,872,781

G

arginine vasopressin

increases expression

EXP

Cocaine increases expression of Avp mRNA in paraventricular nucleus of hypothalamus
Cocaine increases expression of Avp protein in the nucleus accumbens

RGD

PMID:21677651 PMID:19596360

RGD:408418732, RGD:408426004

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

alpha-2-glycoprotein 1, zinc-binding

decreases expression

EXP

Cocaine results in decreased expression of AZGP1 mRNA

NCBI chr12:22,044,685...22,051,248
Ensembl chr12:22,044,751...22,053,020

G

BAALC binder of MAP3K1 and KLF4

decreases expression

ISO

Cocaine results in decreased expression of BAALC mRNA

NCBI chr 7:71,803,640...71,877,608
Ensembl chr 7:71,774,898...71,879,261

G

BTB domain and CNC homolog 1

increases expression

EXP

Cocaine results in increased expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BTB domain and CNC homolog 2

affects expression

ISO

Cocaine affects the expression of BACH2 mRNA

NCBI chr 5:51,428,802...51,779,030
Ensembl chr 5:51,434,870...51,774,234

G

BCL2-associated agonist of cell death

affects expression

ISO

Cocaine affects the expression of BAD mRNA

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BAG cochaperone 1

affects expression

ISO

Cocaine affects the expression of BAG1 mRNA

NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:60,864,476...60,878,161

G

BAG cochaperone 3

affects expression
increases expression

ISO
EXP

Cocaine affects the expression of BAG3 mRNA
Cocaine results in increased expression of BAG3 mRNA

PMID:15681117 PMID:27899881

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BMP and activin membrane-bound inhibitor

affects expression

EXP

Cocaine affects the expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247

G

brain abundant, membrane attached signal protein 1

affects expression

EXP

Cocaine affects the expression of BASP1 mRNA

NCBI chr 2:77,546,628...77,594,297
Ensembl chr 2:77,546,092...77,597,178

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
increases activity
affects expression

ISO
EXP

Cocaine results in increased expression of BAX mRNA
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]
Cocaine results in increased activity of BAX protein
Cocaine affects the expression of BAX mRNA

PMID:11392460 PMID:15681117 PMID:15685203 PMID:17084983 PMID:17635674 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions
increases expression

ISO

[SMARCA5 protein co-treated with BAZ1B protein] results in increased susceptibility to Cocaine; Cocaine promotes the reaction [BAZ1B protein binds to SPHKAP gene]; Cocaine results in increased expression of and affects the activity of BAZ1B protein
Cocaine results in increased expression of BAZ1B mRNA

NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511

G

bromodomain adjacent to zinc finger domain, 2B

increases expression

EXP

Cocaine results in increased expression of BAZ2B mRNA

NCBI chr 3:64,792,984...65,034,547
Ensembl chr 3:64,794,001...65,001,781

G

B-cell receptor-associated protein 31

affects expression

EXP

Cocaine affects the expression of BCAP31 mRNA

NCBI chr X:156,548,911...156,581,002
Ensembl chr X:156,548,911...156,579,371

G

branched chain amino acid transaminase 1

affects expression

EXP

Cocaine affects the expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

butyrylcholinesterase

affects metabolic processing
multiple interactions
increases hydrolysis
increases metabolic processing
decreases response to substance
affects hydrolysis
decreases metabolic processing
affects degradation

ISO

BCHE protein affects the metabolism of Cocaine
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of Benzoic Acid; [BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of ecgonine methyl ester
[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid; [BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester
BCHE protein mutant form results in increased metabolism of Cocaine; BCHE protein results in increased metabolism of Cocaine
BCHE protein mutant form results in decreased susceptibility to Cocaine
BCHE protein modified form results in increased hydrolysis of Cocaine; BCHE protein mutant form results in increased hydrolysis of Cocaine
BCHE protein affects the hydrolysis of Cocaine
BCHE protein mutant form results in decreased metabolism of Cocaine
BCHE protein mutant form affects the degradation of Cocaine

PMID:572161 PMID:16275916 PMID:17989928 PMID:18514178 PMID:18514640 More...

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL11 transcription factor B

increases expression

ISO

Cocaine deficiency results in increased expression of BCL11B mRNA

NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:132,598,968...132,691,301

G

BCL2, apoptosis regulator

affects expression
multiple interactions
decreases expression
increases phosphorylation
increases expression

ISO
EXP

Cocaine affects the expression of BCL2 mRNA
IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]
Cocaine results in increased phosphorylation of BCL2 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]
Cocaine results in decreased expression of BCL2 mRNA; Cocaine results in decreased expression of BCL2 protein
Cocaine results in increased expression of BCL2 protein

PMID:11392460 PMID:15365088 PMID:15681117 PMID:15685203 PMID:17084983 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

increases expression
decreases expression
multiple interactions

EXP
ISO

Cocaine results in increased expression of BCL2L1 mRNA; Cocaine results in increased expression of BCL2L1 mRNA alternative form
Cocaine results in decreased expression of BCL2L1 protein
IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]

PMID:16076954 PMID:29673861 PMID:30393195

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

EXP

Cocaine results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

brain-derived neurotrophic factor

decreases response to substance
increases expression
decreases activity
affects expression
multiple interactions
decreases expression
increases response to substance

ISO
EXP

BDNF mRNA results in decreased susceptibility to Cocaine; BDNF protein results in decreased susceptibility to Cocaine
Cocaine results in increased expression of BDNF mRNA
Cocaine results in decreased activity of BDNF protein
Cocaine results in increased expression of BDNF protein
Cocaine affects the expression of BDNF exon; Cocaine affects the expression of BDNF mRNA; Cocaine affects the expression of BDNF protein
BDNF protein inhibits the reaction [Cocaine results in increased abundance of Amino Acids, Peptides, and Proteins]; Cocaine affects the activity of and affects the expression of BDNF protein; Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]; Cocaine affects the reaction [MECP2 protein affects the expression of BDNF protein]; Cocaine affects the reaction [MECP2 protein binds to and results in decreased activity of BDNF promoter]; Cocaine affects the reaction [MIR212 protein affects the expression of BDNF protein]
BDNF mRNA results in decreased susceptibility to Cocaine; BDNF protein results in decreased susceptibility to Cocaine; BDNF results in decreased susceptibility to Cocaine
(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]; (+)-JQ1 compound inhibits the reaction [Cocaine results in increased expression of BDNF mRNA]; Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]; Cocaine inhibits the reaction [MECP2 protein binds to BDNF promoter]; Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of BDNF mRNA]; Haloperidol inhibits the reaction [Cocaine results in decreased expression of BDNF protein]
Cocaine results in decreased expression of BDNF mRNA; Cocaine results in decreased expression of BDNF protein
BDNF results in increased susceptibility to Cocaine

PMID:12099907 PMID:14973246 PMID:16423334 PMID:17194538 PMID:17618281 More...

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

brain-enriched guanylate kinase-associated

affects expression

EXP

Cocaine affects the expression of BEGAIN mRNA

NCBI chr 6:133,708,010...133,744,264
Ensembl chr 6:133,708,007...133,744,526

G

basic helix-loop-helix family, member e22

increases expression

EXP

Cocaine results in increased expression of BHLHE22 mRNA

NCBI chr 2:102,402,622...102,405,732
Ensembl chr 2:102,400,164...102,420,508

G

basic helix-loop-helix family, member e40

affects expression

EXP

Cocaine affects the expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

BH3 interacting domain death agonist

affects expression

ISO

Cocaine affects the expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2-interacting killer

affects expression

ISO

Cocaine affects the expression of BIK mRNA

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

basic helix-loop-helix ARNT like 1

decreases expression

ISO

Cocaine results in decreased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739

G

BMP-2 inducible kinase

affects expression

EXP

Cocaine affects the expression of BMP2K mRNA

NCBI chr14:12,785,169...12,882,676
Ensembl chr14:12,785,169...12,882,657

G

bone morphogenetic protein receptor type 2

increases expression

EXP

Cocaine results in increased expression of BMPR2 mRNA

NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350

G

BCL2 interacting protein 2

affects expression

ISO

Cocaine affects the expression of BNIP2 mRNA

NCBI chr 8:79,521,375...79,539,148
Ensembl chr 8:79,521,363...79,547,368

G

BCL2 interacting protein 3

affects expression

ISO

Cocaine affects the expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

affects expression

ISO

Cocaine affects the expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

bromodomain containing 4

multiple interactions
increases expression

ISO
EXP

(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]; Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]
Cocaine results in increased expression of BRD4 protein

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923

G

BSCL2 lipid droplet biogenesis associated, seipin

affects expression

EXP

Cocaine affects the expression of BSCL2 mRNA

NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:215,160,957...215,172,536

G

bone marrow stromal cell antigen 1

affects expression

EXP

Cocaine affects the expression of BST1 mRNA

NCBI chr14:71,466,179...71,482,671
Ensembl chr14:71,466,180...71,482,647

G

BTB domain containing 9

increases expression

EXP

Cocaine results in increased expression of BTBD9 mRNA

NCBI chr20:8,287,813...8,645,437
Ensembl chr20:8,290,456...8,641,292

G

BTG anti-proliferation factor 2

affects expression

EXP

Cocaine affects the expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

Bruton tyrosine kinase

decreases expression

EXP

Cocaine results in decreased expression of BTK mRNA

NCBI chr X:102,016,070...102,055,448
Ensembl chr X:102,016,074...102,055,143

G

complement C1q binding protein

decreases expression

EXP

Cocaine results in decreased expression of C1QBP protein

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235

G

C1q and TNF related 1

affects expression

EXP

Cocaine affects the expression of C1QTNF1 mRNA

NCBI chr10:104,159,021...104,180,253
Ensembl chr10:104,158,886...104,180,251

G

C1q and TNF related 4

decreases expression

EXP

Cocaine results in decreased expression of C1QTNF4 mRNA

NCBI chr 3:97,310,220...97,328,818
Ensembl chr 3:97,327,670...97,342,587

G

C2 domain containing 3 centriole elongation regulator

decreases expression

EXP

Cocaine results in decreased expression of C2CD3 mRNA

NCBI chr 1:164,127,304...164,225,088
Ensembl chr 1:164,127,281...164,225,086

G

C2 calcium-dependent domain containing 4D

decreases expression

EXP

Cocaine results in decreased expression of C2CD4D mRNA

NCBI chr 2:184,688,815...184,690,978
Ensembl chr 2:184,677,258...184,691,381

G

similar to human chromosome 11 open reading frame 96

increases expression

EXP

Cocaine results in increased expression of C3H11ORF96 mRNA

NCBI chr 3:100,375,474...100,376,717
Ensembl chr 3:100,351,199...100,378,346

G

carbonic anhydrase 4

decreases expression

EXP

Cocaine results in decreased expression of CAR4 mRNA

NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916

G

calcium binding protein 39-like

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of CAB39L mRNA

NCBI chr15:37,782,778...37,885,191
Ensembl chr15:37,782,870...37,919,742

G

calcium voltage-gated channel subunit alpha1 D

affects response to substance

ISO

CACNA1D polymorphism affects the susceptibility to Cocaine

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692

G

calcium voltage-gated channel auxiliary subunit beta 3

affects expression

EXP

Cocaine affects the expression of CACNB3 mRNA

NCBI chr 7:131,663,810...131,676,085
Ensembl chr 7:131,662,545...131,676,085

G

caldesmon 1

affects expression

EXP

Cocaine affects the expression of CALD1 mRNA

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

calmodulin 1

decreases expression

ISO

Cocaine results in decreased expression of CALM1 mRNA

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calmodulin 2

decreases expression

ISO

Cocaine results in decreased expression of CALM2 mRNA

NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657

G

calreticulin

decreases expression
multiple interactions
affects expression

ISO
EXP

Cocaine results in decreased expression of CALR mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of CALR mRNA]
Cocaine affects the expression of CALR mRNA

PMID:18355967 PMID:20187946

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

calcyon neuron-specific vesicular protein

increases expression

EXP

Cocaine results in increased expression of CALY mRNA

NCBI chr 1:204,292,317...204,303,506
Ensembl chr 1:204,292,318...204,303,196

G

calcium/calmodulin-dependent protein kinase IG

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of CAMK1G mRNA

NCBI chr13:107,406,583...107,430,332
Ensembl chr13:107,406,584...107,430,230

G

calcium/calmodulin-dependent protein kinase II alpha

affects response to substance
increases expression
multiple interactions

ISO
EXP

CAMK2A affects the susceptibility to Cocaine
Cocaine results in increased expression of CAMK2A protein
7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]; Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]; Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]
Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein; Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]

PMID:14725635 PMID:17609678 PMID:19217379 PMID:28194001

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression
affects expression

ISO
EXP

Cocaine results in decreased expression of CAMK2B mRNA
Cocaine affects the expression of CAMK2B mRNA

PMID:17205118 PMID:20187946

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase IV

increases response to substance
decreases response to substance

ISO

CAMK4 promoter SNP results in increased susceptibility to Cocaine
CAMK4 protein results in decreased susceptibility to Cocaine

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193

G

cyclase associated actin cytoskeleton regulatory protein 2

affects expression

EXP

Cocaine affects the expression of CAP2 mRNA

NCBI chr17:18,260,462...18,409,681
Ensembl chr17:18,261,646...18,409,563

G

capping actin protein of muscle Z-line subunit beta

decreases expression

ISO

Cocaine results in decreased expression of CAPZB mRNA

NCBI chr 5:156,718,619...156,818,623
Ensembl chr 5:156,650,432...156,818,619

G

caspase recruitment domain family, member 11

decreases expression

EXP

Cocaine results in decreased expression of CARD11 mRNA

NCBI chr12:18,735,088...18,872,045
Ensembl chr12:18,735,088...18,872,045

G

coactivator-associated arginine methyltransferase 1

affects expression

EXP

Cocaine affects the expression of CARM1 mRNA

NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:28,373,362...28,418,056

G

carnosine N-methyltransferase 1

affects expression

EXP

Cocaine affects the expression of CARNMT1 mRNA

NCBI chr 1:225,520,345...225,549,971
Ensembl chr 1:225,520,151...225,550,232

G

CART prepropeptide

increases expression
affects expression

ISO
EXP

Cocaine results in increased expression of CARTPT mRNA
Cocaine affects the expression of CARTPT mRNA

PMID:15009677 PMID:17851536 PMID:20187946

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712

G

caspase 2

increases activity
increases expression

EXP

Cocaine results in increased activity of CASP2 protein
Cocaine results in increased expression of CASP2 mRNA

PMID:16076954 PMID:16638611

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases expression
increases cleavage
multiple interactions
increases activity
affects expression

ISO
EXP

Cocaine results in increased expression of CASP3 protein
Cocaine results in increased cleavage of CASP3 protein
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; PRKCD protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]
Cocaine results in increased activity of CASP3 protein
Cocaine affects the expression of CASP3 protein
[Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Cocaine results in increased cleavage of and results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP3 protein]
Cocaine affects the expression of CASP3 mRNA

PMID:10604926 PMID:11392460 PMID:12639677 PMID:14741756 PMID:15365088 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

affects expression
decreases expression

ISO

Cocaine affects the expression of CASP4 mRNA
Cocaine results in decreased expression of CASP4 mRNA

PMID:12629581 PMID:15681117

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 8

affects expression
increases activity

ISO
EXP

Cocaine affects the expression of CASP8 mRNA
Cocaine results in increased activity of CASP8 protein

PMID:11392460 PMID:15681117 PMID:18974856

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

affects expression
increases activity
multiple interactions
increases expression

ISO
EXP

Cocaine affects the expression of CASP9 mRNA
Cocaine results in increased activity of CASP9 protein
SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP9 protein]
Cocaine affects the expression of CASP9 protein
Cocaine results in increased expression of CASP9 protein

PMID:10604926 PMID:11392460 PMID:12639677 PMID:15365088 PMID:15681117 More...

Ensembl chr 5:159,391,188...159,409,648

G

cytosolic arginine sensor for mTORC1 subunit 1

affects expression

EXP

Cocaine affects the expression of CASTOR1 mRNA

NCBI chr14:83,309,710...83,314,123
Ensembl chr14:83,309,504...83,314,127

G

catalase

decreases activity
increases activity
increases expression

ISO
EXP

Cocaine results in decreased activity of CAT protein
Cocaine results in increased activity of CAT protein
Cocaine results in increased expression of CAT protein

PMID:14576513 PMID:16085363 PMID:29475069

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cation channel, sperm associated 2

increases expression

EXP

Cocaine results in increased expression of CATSPER2 mRNA

NCBI chr 3:128,822,387...128,842,501
Ensembl chr 3:128,822,391...128,842,261

G

cerebellin 1 precursor

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of CBLN1 mRNA

NCBI chr19:35,782,151...35,785,960
Ensembl chr19:35,781,952...35,785,960

G

coiled-coil domain containing 127

increases expression

EXP

Cocaine results in increased expression of CCDC127 mRNA

NCBI chr 1:30,757,010...30,764,473
Ensembl chr 1:30,757,010...30,764,473

G

coiled-coil domain containing 174

affects expression

EXP

Cocaine affects the expression of CCDC174 mRNA

NCBI chr 4:125,949,203...125,976,179
Ensembl chr 4:125,949,420...125,976,178

G

coiled-coil domain containing 73

decreases expression

EXP

Cocaine results in decreased expression of CCDC73 mRNA

NCBI chr 3:111,737,771...111,879,588
Ensembl chr 3:111,737,730...111,880,105

G

coiled coil domain containing 88A

increases expression

EXP

Cocaine results in increased expression of CCDC88A mRNA

NCBI chr14:107,304,654...107,456,104
Ensembl chr14:107,305,199...107,453,285

G

coiled-coil domain containing 93

increases expression

EXP

Cocaine results in increased expression of CCDC93 mRNA

NCBI chr13:35,160,354...35,233,877
Ensembl chr13:35,160,363...35,233,875

G

cholecystokinin B receptor

decreases expression
increases response to substance

ISO

Cocaine results in decreased expression of CCKBR mRNA
CCKBR protein results in increased susceptibility to Cocaine

PMID:11403953 PMID:18000554

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745

G

C-C motif chemokine ligand 2

increases secretion
increases expression
multiple interactions

ISO
EXP

Cocaine results in increased secretion of CCL2 protein
Cocaine results in increased expression of CCL2 mRNA; Cocaine results in increased expression of CCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; AG 1879 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; Cocaine promotes the reaction [RELA protein binds to CCL2 promoter]; methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; RELA mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SC 514 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; U 0126 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]

PMID:10065903 PMID:20354174

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases secretion

ISO

Cocaine results in increased secretion of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cellular communication network factor 2

decreases expression

ISO

Cocaine results in decreased expression of CCN2 mRNA; Cocaine results in decreased expression of CCN2 protein

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cellular communication network factor 3

increases expression

EXP

Cocaine results in increased expression of CCN3 mRNA

NCBI chr 7:87,983,788...87,990,810
Ensembl chr 7:87,982,216...87,994,581

G

cyclin A2

decreases expression

ISO
EXP

Cocaine results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin D1

affects expression

EXP

Cocaine affects the expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D3

affects expression

EXP

Cocaine affects the expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin L1

increases expression

EXP

Cocaine results in increased expression of CCNL1 mRNA

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468

G

C-C motif chemokine receptor 2

affects expression
increases response to substance

EXP
ISO

Cocaine affects the expression of CCR2 mRNA
CCR2 results in increased susceptibility to Cocaine

PMID:20187946 PMID:20354174

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059

G

C-C motif chemokine receptor 5

increases expression

ISO

Cocaine results in increased expression of CCR5 protein

NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594

G

coiled-coil serine-rich protein 1

affects response to substance

ISO

CCSER1 gene SNP affects the susceptibility to Cocaine

NCBI chr 4:91,483,896...92,720,439
Ensembl chr 4:91,483,770...92,718,789

G

chaperonin containing TCP1 subunit 2

affects expression

EXP

Cocaine affects the expression of CCT2 mRNA

NCBI chr 7:54,578,654...54,591,428
Ensembl chr 7:54,578,663...54,592,977

G

CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

decreases expression

ISO

Cocaine results in decreased expression of CCZ1 mRNA

NCBI chr12:15,714,768...15,738,273
Ensembl chr12:15,714,748...15,738,268

G

CD180 molecule

decreases expression

EXP

Cocaine results in decreased expression of CD180 mRNA

NCBI chr 2:35,589,889...35,602,837
Ensembl chr 2:35,589,451...35,603,982

G

Cd276 molecule

affects expression

EXP

Cocaine affects the expression of CD276 mRNA

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

Cd4 molecule

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of CD4 mRNA

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461

G

CD44 molecule

decreases expression

ISO

Cocaine results in decreased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd47 molecule

affects expression

EXP

Cocaine affects the expression of CD47 mRNA

NCBI chr11:64,374,816...64,438,763
Ensembl chr11:64,377,926...64,438,272

G

CD74 molecule

affects expression

EXP

Cocaine affects the expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410

G

Cd81 molecule

increases response to substance
increases expression
affects response to substance

ISO
EXP

CD81 protein results in increased susceptibility to Cocaine
Cocaine results in increased expression of CD81 mRNA
CD81 protein affects the susceptibility to Cocaine

PMID:11178868 PMID:12113778 PMID:15715673

NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:207,664,885...207,681,092

G

CD93 molecule

decreases expression

EXP

Cocaine results in decreased expression of CD93 mRNA

NCBI chr 3:156,345,019...156,351,537
Ensembl chr 3:156,345,019...156,351,537

G

cell division cycle 14B

decreases expression

EXP

Cocaine results in decreased expression of CDC14B mRNA

NCBI chr17:850,272...938,972
Ensembl chr17:850,390...971,164

G

cell division cycle 25A

increases expression

EXP

Cocaine results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cadherin 1

decreases expression

ISO

Cocaine results in decreased expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 16

affects expression

EXP

Cocaine affects the expression of CDH16 mRNA

NCBI chr19:367,202...377,710
Ensembl chr19:367,274...388,934

G

cadherin 17

decreases expression

ISO

Cocaine results in decreased expression of CDH17 mRNA

NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226

G

cyclin-dependent kinase 18

affects expression

EXP

Cocaine affects the expression of CDK18 mRNA

NCBI chr13:46,107,763...46,140,705
Ensembl chr13:46,108,911...46,140,865

G

cyclin-dependent kinase 4

affects expression

ISO

Cocaine affects the expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 5

affects expression
increases expression
decreases expression

EXP

Cocaine affects the expression of CDK5 mRNA; Cocaine affects the expression of CDK5 protein
Cocaine results in increased expression of CDK5 mRNA; Cocaine results in increased expression of CDK5 protein
Cocaine results in decreased expression of CDK5 protein

PMID:11268215 PMID:12787079 PMID:16263094 PMID:17339080 PMID:17680995 More...

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions
increases expression
decreases expression

ISO
EXP

CDK5R1 protein inhibits the reaction [Cocaine affects the expression of FOS mRNA]; CDK5R1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK3 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
Cocaine results in increased expression of CDK5R1 mRNA; Cocaine results in increased expression of CDK5R1 protein
Cocaine results in decreased expression of CDK5R1 protein

PMID:11268215 PMID:15665076 PMID:16263094

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

cyclin-dependent kinase inhibitor 1A

increases expression

EXP

Cocaine results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CEA cell adhesion molecule 9

affects expression

EXP

Cocaine affects the expression of CEACAM3 mRNA

NCBI chr 1:86,533,724...86,538,259
Ensembl chr 1:86,533,724...86,538,260

G

carboxyl ester lipase

increases expression

EXP

Cocaine results in increased expression of CEL mRNA

NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019

G

carboxylesterase 1D

multiple interactions
increases hydrolysis
affects binding

ISO

CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol]; Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
CES1 protein results in increased hydrolysis of Cocaine
Cocaine binds to CES1 protein

PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 PMID:25445008

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

carboxylesterase 2H

multiple interactions
decreases expression
increases hydrolysis

ISO

Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin]
Cocaine results in decreased expression of CES2 mRNA
CES2 protein results in increased hydrolysis of Cocaine

PMID:8930175 PMID:9169443 PMID:12629581

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

complement factor H

decreases expression

EXP

Cocaine results in decreased expression of CFH mRNA

NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532

G

CASP8 and FADD-like apoptosis regulator

affects expression

ISO

Cocaine affects the expression of CFLAR mRNA

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

choline O-acetyltransferase

increases expression

ISO

Cocaine results in increased expression of CHAT protein

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

checkpoint with forkhead and ring finger domains

affects expression

EXP

Cocaine affects the expression of CHFR mRNA

NCBI chr12:52,164,214...52,197,860
Ensembl chr12:52,164,217...52,197,703

G

chimerin 1

affects expression

EXP

Cocaine affects the expression of CHN1 mRNA

NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:78,917,329...79,084,197

G

cholinergic receptor, muscarinic 1

increases expression

ISO

Cocaine results in increased expression of CHRM1 protein

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 3

increases expression

ISO

Cocaine results in increased expression of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor, muscarinic 4

affects expression

EXP

Cocaine affects the expression of CHRM4 mRNA

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

cholinergic receptor, muscarinic 5

decreases response to substance
increases expression

EXP
ISO

CHRM5 mutant form results in decreased susceptibility to Cocaine
Cocaine results in increased expression of CHRM5 protein

PMID:20393457 PMID:35597300

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

EXP

Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

EXP

Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105

G

cholinergic receptor nicotinic alpha 5 subunit

decreases response to substance

ISO

CHRNA5 gene polymorphism results in decreased susceptibility to Cocaine

NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:64,265,879...64,294,233

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions
increases response to substance

EXP
ISO

Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CHRNB2 protein results in increased susceptibility to Cocaine

PMID:10336510 PMID:11282258

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

cholinergic receptor nicotinic epsilon subunit

increases expression

EXP

Cocaine results in increased expression of CHRNE mRNA

NCBI chr10:55,829,835...55,838,853
Ensembl chr10:55,829,836...55,834,154

G

chromosome transmission fidelity factor 8

decreases expression

EXP

Cocaine results in decreased expression of CHTF8 mRNA

NCBI chr19:51,691,776...51,702,076
Ensembl chr19:51,678,543...51,707,144

G

churchill domain containing 1

decreases expression

ISO

Cocaine results in decreased expression of CHURC1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 6:101,203,778...101,218,364
Ensembl chr 6:101,203,841...101,237,748

G

cytosolic iron-sulfur assembly component 1

affects expression

EXP

Cocaine affects the expression of CIAO1 mRNA

NCBI chr 3:134,913,639...134,919,244
Ensembl chr 3:134,913,172...134,979,255

G

cell death-inducing DFFA-like effector a

affects expression

ISO

Cocaine affects the expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

cell death-inducing DFFA-like effector b

affects expression

ISO

Cocaine affects the expression of CIDEB mRNA

NCBI chr15:33,222,135...33,226,407
Ensembl chr15:33,221,824...33,226,688

G

CDGSH iron sulfur domain 1

increases expression

EXP

Cocaine results in increased expression of CISD1 protein

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042

G

CDGSH iron sulfur domain 2

increases expression

EXP

Cocaine results in increased expression of CISD2 mRNA

NCBI chr 2:226,502,517...226,527,325
Ensembl chr 2:226,502,517...226,540,080

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

decreases expression

EXP

Cocaine results in decreased expression of CITED4 mRNA

NCBI chr 5:139,532,165...139,533,056
Ensembl chr 5:139,531,584...139,533,361

G

creatine kinase B

multiple interactions

ISO

Cocaine results in increased secretion of [CKB protein binds to CKM protein]

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

ISO

Cocaine results in increased secretion of [CKB protein binds to CKM protein]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

creatine kinase, mitochondrial 1

affects expression

EXP

Cocaine affects the expression of CKMT1 mRNA

NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:128,783,597...128,789,483

G

chloride voltage-gated channel 7

affects expression

EXP

Cocaine affects the expression of CLCN7 mRNA

NCBI chr10:14,656,261...14,681,632
Ensembl chr10:14,656,245...14,681,631

G

claudin 11

decreases expression

ISO

Cocaine results in decreased expression of CLDN11 mRNA

NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:114,136,234...114,149,539

G

C-type lectin domain family 4, member F

affects expression

EXP

Cocaine affects the expression of CLEC4F mRNA

NCBI chr 4:117,686,686...117,696,407
Ensembl chr 4:117,686,686...117,696,438

G

chloride intracellular channel 1

decreases expression

ISO

Cocaine results in decreased expression of CLIC1 mRNA

NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367

G

CAP-GLY domain containing linker protein 1

increases expression

ISO

Cocaine results in increased expression of CLIP1 mRNA

NCBI chr12:38,571,533...38,678,779
Ensembl chr12:38,571,834...38,678,779

G

CDC-like kinase 1

increases expression
multiple interactions

ISO

Cocaine results in increased expression of CLK1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CLK1 mRNA]

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

CDC-like kinase 4

increases expression

ISO

Cocaine results in increased expression of CLK4 mRNA

NCBI chr10:36,024,364...36,042,366
Ensembl chr10:36,024,427...36,042,372

G

clock circadian regulator

increases expression

ISO

Cocaine results in increased expression of CLOCK mRNA

NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872

G

clathrin, light chain B

decreases expression

ISO

Cocaine results in decreased expression of CLTB mRNA

PMID:12629581 PMID:15009677

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915

G

citramalyl-CoA lyase

increases expression

EXP

Cocaine results in increased expression of CLYBL protein

NCBI chr15:105,690,283...105,912,347
Ensembl chr15:105,690,295...105,912,345

G

cyclic nucleotide binding domain containing 2

increases expression

EXP

Cocaine results in increased expression of CNBD2 mRNA

NCBI chr 3:165,279,157...165,357,582
Ensembl chr 3:165,279,204...165,361,688

G

connector enhancer of kinase suppressor of Ras 2

increases expression

ISO

Cocaine results in increased expression of CNKSR2 mRNA

NCBI chr X:40,722,843...40,971,730
Ensembl chr X:40,722,996...40,965,604

G

cannabinoid receptor 1

affects response to substance
increases activity
decreases response to substance
multiple interactions

ISO

CNR1 gene polymorphism affects the susceptibility to Cocaine; CNR1 gene SNP affects the susceptibility to Cocaine; CNR1 polymorphism affects the susceptibility to Cocaine
Cocaine results in increased activity of CNR1 protein
CNR1 mutant form results in decreased susceptibility to Cocaine
CNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased expression of FOS protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:9106242 PMID:16314880 PMID:17596442 PMID:19052543 PMID:20554863

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

cannabinoid receptor 2

increases expression

ISO

Cocaine results in increased expression of CNR2 mRNA

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961

G

cordon-bleu WH2 repeat protein-like 1

increases expression
increases expression

ISO

Cocaine results in increased expression of COBLL1 mRNA
cocaine increases expression of Colbl1 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr 3:70,161,369...70,324,844
Ensembl chr 3:70,161,372...70,323,460

G

coilin

affects expression

EXP

Cocaine affects the expression of COIL mRNA

NCBI chr10:74,286,279...74,307,597
Ensembl chr10:74,286,840...74,307,595

G

collagen type XV alpha 1 chain

affects expression

EXP

Cocaine affects the expression of COL15A1 mRNA

NCBI chr 5:66,297,546...66,403,172
Ensembl chr 5:66,297,461...66,403,170

G

collagen type I alpha 1 chain

increases expression

EXP

Cocaine results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

increases expression

EXP

Cocaine results in increased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

coenzyme Q6 monooxygenase

affects expression

EXP

Cocaine affects the expression of COQ6 mRNA

NCBI chr 6:109,738,934...109,750,315
Ensembl chr 6:109,738,951...109,750,310

G

coronin 7

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of CORO7 mRNA

NCBI chr10:11,386,683...11,447,422
Ensembl chr10:11,391,613...11,447,866

G

cytochrome c oxidase assembly factor COX20

decreases expression

EXP

Cocaine results in decreased expression of COX20 mRNA

NCBI chr13:92,592,260...92,604,129
Ensembl chr14:6,872,315...6,872,638

G

cytochrome c oxidase subunit 5A

affects expression

EXP

Cocaine affects the expression of COX5A mRNA

NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279

G

cytochrome c oxidase subunit 6A1

affects expression
increases expression

EXP

Cocaine affects the expression of COX6A1 mRNA
Cocaine results in increased expression of COX6A1 protein

PMID:20187946 PMID:25100957

NCBI chr12:46,922,709...46,925,762
Ensembl chr12:46,912,648...46,925,768

G

cytochrome c oxidase subunit 6C

decreases expression

ISO

Cocaine results in decreased expression of COX6C mRNA

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166

G

cytochrome c oxidase subunit 7B

affects expression

EXP

Cocaine affects the expression of COX7B mRNA

NCBI chr X:75,149,036...75,155,285
Ensembl chr X:75,148,996...75,155,284

G

cytochrome c oxidase subunit 8A

affects expression

EXP

Cocaine affects the expression of COX8A mRNA

NCBI chr 1:213,831,302...213,833,623
Ensembl chr 1:213,831,298...213,833,623

G

complexin 1

affects expression

EXP

Cocaine affects the expression of CPLX1 mRNA

NCBI chr14:1,329,073...1,360,781
Ensembl chr14:1,329,032...1,360,769

G

copine 8

increases expression

EXP

Cocaine results in increased expression of CPNE8 mRNA

NCBI chr 7:123,494,864...123,669,060
Ensembl chr 7:123,494,865...123,669,060

G

cAMP responsive element binding protein 1

affects expression
increases phosphorylation
multiple interactions
affects phosphorylation
increases expression

EXP
ISO

Cocaine affects the expression of CREB1 mRNA
cocaine increases phosphorylation of Creb1 protein in nucleus accumbens
Cocaine results in increased phosphorylation of CREB1 protein
CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of CREB1 protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]
Cocaine affects the phosphorylation of CREB1 protein
Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein]; Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]; Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of CREB1 protein; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]

CTD
RGD

PMID:12595601 PMID:15470197 PMID:15665076 PMID:16219028 PMID:16339038 More...

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

increases expression

EXP

Cocaine results in increased expression of CREBBP mRNA

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

CREB3 regulatory factor

increases expression

EXP

Cocaine results in increased expression of CREBRF mRNA

NCBI chr10:16,903,607...16,967,450
Ensembl chr10:16,903,547...16,966,430

G

cAMP responsive element modulator

affects expression
increases expression

ISO
EXP

Cocaine affects the expression of CREM mRNA
Cocaine results in increased expression of CREM mRNA

PMID:18355967 PMID:27899881

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

corticotropin releasing hormone

multiple interactions
affects expression

EXP

Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA]; Cocaine affects the reaction [CRH protein affects the secretion of Excitatory Amino Acid Agents]; SCH 23390 affects the reaction [Cocaine affects the expression of CRH mRNA]
Cocaine affects the expression of CRH mRNA; Cocaine affects the expression of CRH protein

PMID:7796157 PMID:11597771 PMID:12782395 PMID:15930388 PMID:18596687

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

corticotropin releasing hormone binding protein

increases expression

EXP

Cocaine results in increased expression of CRHBP mRNA

NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:28,427,139...28,439,446

G

corticotropin releasing hormone receptor 1

increases expression

EXP

Cocaine results in increased expression of CRHR1 protein

NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466

G

cysteine-rich protein 2

affects expression

EXP

Cocaine affects the expression of CRIP2 mRNA

NCBI chr 6:138,042,175...138,047,121
Ensembl chr 6:138,041,906...138,047,120

G

cysteine-rich secretory protein LCCL domain containing 1

decreases expression

EXP

Cocaine results in decreased expression of CRISPLD1 mRNA

NCBI chr 5:6,050,970...6,098,265
Ensembl chr 5:6,051,891...6,098,265

G

C-reactive protein

increases expression

ISO

Cocaine results in increased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

cartilage acidic protein 1

affects expression

EXP

Cocaine affects the expression of CRTAC1 mRNA

NCBI chr 1:251,040,963...251,182,920
Ensembl chr 1:251,028,143...251,182,689

G

CREB regulated transcription coactivator 1

multiple interactions

EXP

[[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein

NCBI chr16:19,022,171...19,080,880
Ensembl chr16:19,022,005...19,080,880

G

cryptochrome circadian regulator 1

decreases expression

ISO

Cocaine results in decreased expression of CRY1 mRNA

NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822

G

cryptochrome circadian regulator 2

decreases expression

ISO

Cocaine results in decreased expression of CRY2 mRNA

NCBI chr 3:98,830,479...98,860,437
Ensembl chr 3:98,830,483...98,860,447

G

crystallin, alpha B

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of CRYAB mRNA
Cocaine results in increased expression of CRYAB mRNA

PMID:15009677 PMID:27899881

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

crystallin, beta B2

decreases expression

ISO

Cocaine results in decreased expression of CRYBB2 mRNA

NCBI chr12:49,230,192...49,240,116
Ensembl chr12:49,230,192...49,240,116

G

cysteine sulfinic acid decarboxylase

affects expression
decreases expression

EXP

Cocaine affects the expression of CSAD mRNA
Cocaine results in decreased expression of CSAD protein

PMID:20187946 PMID:25100957

NCBI chr 7:135,187,175...135,216,495
Ensembl chr 7:135,187,175...135,215,581

G

colony stimulating factor 2 receptor subunit alpha

decreases expression

EXP

Cocaine results in decreased expression of CSF2RA mRNA

NCBI chr14:113,219...118,808
Ensembl chr14:113,225...118,117

G

casein kappa

affects expression

EXP

Cocaine affects the expression of CSN3 mRNA

NCBI chr14:20,433,277...20,439,830
Ensembl chr14:20,433,277...20,439,832

G

casein kinase 2 alpha 1

decreases expression

EXP

Cocaine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

chondroitin sulfate proteoglycan 5

affects expression

EXP

Cocaine affects the expression of CSPG5 mRNA; Cocaine affects the expression of CSPG5 protein

NCBI chr 8:119,098,932...119,113,191
Ensembl chr 8:119,098,925...119,143,907

G

cysteine and glycine-rich protein 2

decreases expression

ISO

Cocaine results in decreased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

CTD nuclear envelope phosphatase 1

affects expression

EXP

Cocaine affects the expression of CTDNEP1 mRNA

NCBI chr10:55,203,047...55,212,469
Ensembl chr10:55,203,543...55,212,852

G

catenin beta 1

affects expression
multiple interactions

EXP

Cocaine affects the expression of CTNNB1 mRNA
Cocaine deficiency promotes the reaction [SMARCA4 protein binds to CTNNB1 promoter]

PMID:20187946 PMID:27422367

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

catenin, beta-interacting protein 1

decreases expression

ISO

Cocaine results in decreased expression of CTNNBIP1 mRNA

NCBI chr 5:165,245,019...165,293,994
Ensembl chr 5:165,245,098...165,293,991

G

catenin delta 2

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of CTNND2 mRNA
Cocaine results in increased expression of CTNND2 mRNA

PMID:12629581 PMID:16076954

NCBI chr 2:82,879,469...83,727,409
Ensembl chr 2:82,879,469...83,727,409

G

chymotrypsin-like

affects expression
increases expression

EXP

Cocaine affects the expression of CTRL mRNA
Cocaine results in increased expression of CTRL mRNA

PMID:20187946 PMID:27899881

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979

G

cathepsin B

affects expression
multiple interactions
increases expression

ISO

Cocaine affects the expression of CTSB mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CTSB mRNA]

PMID:15681117 PMID:18355967

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

affects expression
increases expression

ISO
EXP

Cocaine affects the expression of CTSD mRNA
Cocaine results in increased expression of CTSD protein

PMID:15681117 PMID:25100957

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

CUE domain containing 1

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of CUEDC1 mRNA]

NCBI chr10:73,389,798...73,484,914
Ensembl chr10:73,389,841...73,483,749

G

cullin 4B

increases expression

ISO

Cocaine results in increased expression of CUL4B mRNA

NCBI chr X:122,154,332...122,192,299
Ensembl chr X:122,154,332...122,192,299

G

CWF19 like cell cycle control factor 2

increases expression

EXP

Cocaine results in increased expression of CWF19L2 mRNA

NCBI chr 6:6,036,158...6,102,686
Ensembl chr 6:6,026,861...6,102,635

G

C-X3-C motif chemokine ligand 1

increases expression

EXP

Cocaine results in increased expression of CX3CL1 mRNA

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

C-X-C motif chemokine ligand 10

increases secretion

ISO

Cocaine results in increased secretion of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 9

decreases expression

EXP

Cocaine results in decreased expression of CXCL9 mRNA

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

C-X-C motif chemokine receptor 4

increases expression

ISO

Cocaine results in increased expression of CXCR4 protein

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

CXXC finger protein 5

affects expression

EXP

Cocaine affects the expression of CXXC5 mRNA

NCBI chr18:27,701,650...27,732,633
Ensembl chr18:27,701,188...27,732,635

G

cytochrome b-245 alpha chain

increases expression

ISO

Cocaine results in increased expression of CYBA protein

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome b-245 beta chain

increases expression
increases response to substance

ISO

Cocaine results in increased expression of CYBB protein
CYBB results in increased susceptibility to Cocaine

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome c-1

decreases expression

ISO

Cocaine results in decreased expression of CYC1 mRNA

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657

G

cytochrome c, somatic

multiple interactions
affects expression

EXP
ISO

Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]
Cocaine affects the expression of CYCS mRNA

PMID:15681117 PMID:21424555

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytoglobin

decreases expression

EXP

Cocaine results in decreased expression of CYGB protein

NCBI chr10:102,376,506...102,386,272
Ensembl chr10:102,376,507...102,386,272

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases expression

EXP

Cocaine results in decreased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO

Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]; Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 26, subfamily a, polypeptide 1

affects expression

EXP

Cocaine affects the expression of CYP26A1 mRNA

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases response to substance

EXP

CYP26B1 protein results in decreased susceptibility to Cocaine

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases expression

ISO

Cocaine results in decreased expression of CYP2C8 mRNA; Cocaine results in decreased expression of CYP2C8 protein

G

cytochrome P450, family 2, subfamily j, polypeptide 10

decreases expression

EXP

Cocaine results in decreased expression of CYP2J10 mRNA

NCBI chr 5:116,076,012...116,110,914
Ensembl chr 5:116,023,198...116,110,897

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases expression
multiple interactions

ISO

Cocaine results in increased expression of CYP2J2 protein
Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]; Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression

EXP

Cocaine affects the expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 51

decreases expression

ISO

Cocaine results in decreased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

cystatin S

affects expression

EXP

Cocaine affects the expression of CYSS mRNA

NCBI chr 3:157,892,660...157,897,265
Ensembl chr 3:157,892,660...157,897,265

G

DAB2 interacting protein

decreases expression

EXP

Cocaine results in decreased expression of DAB2IP mRNA

NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:39,312,745...39,483,730

G

DAZ associated protein 1

affects expression

EXP

Cocaine affects the expression of DAZAP1 mRNA

NCBI chr 7:10,074,342...10,098,810
Ensembl chr 7:10,074,849...10,095,599

G

dopamine beta-hydroxylase

increases response to substance
decreases response to substance

ISO

DBH gene polymorphism results in increased susceptibility to Cocaine
DBH gene mutant form results in decreased susceptibility to Cocaine

PMID:10673769 PMID:12555232 PMID:18083142

NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316

G

drebrin 1

multiple interactions

EXP

Cocaine deficiency promotes the reaction [SMARCA4 protein binds to DBN1 promoter]

NCBI chr17:9,155,729...9,170,121
Ensembl chr17:9,155,787...9,170,122

G

DDB1 and CUL4 associated factor 8

affects expression

EXP

Cocaine affects the expression of DCAF8 mRNA

NCBI chr13:87,141,940...87,199,859
Ensembl chr13:87,142,525...87,202,099

G

DNA-damage inducible transcript 3

affects expression
increases expression

ISO
EXP

Cocaine affects the expression of DDIT3 mRNA
Cocaine results in increased expression of DDIT3 mRNA

PMID:15681117 PMID:20187946 PMID:23644055

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

discoidin domain receptor tyrosine kinase 2

decreases expression

EXP

Cocaine results in decreased expression of DDR2 mRNA

NCBI chr13:84,726,412...84,851,032
Ensembl chr13:84,731,180...84,850,288

G

DEAD-box helicase 41

decreases expression

ISO

Cocaine results in decreased expression of DDX41 mRNA

NCBI chr17:9,108,030...9,113,562
Ensembl chr17:9,108,074...9,113,561

G

DExD-box helicase 50

affects expression

EXP

Cocaine affects the expression of DDX50 mRNA

NCBI chr20:31,104,354...31,133,652
Ensembl chr20:31,104,354...31,133,652

G

DEAD-box helicase 6

increases expression

EXP

Cocaine results in increased expression of DDX6 mRNA

NCBI chr 8:53,827,661...53,864,538
Ensembl chr 8:53,827,835...53,860,977

G

DEAF1 transcription factor

decreases expression

ISO

Cocaine results in decreased expression of DEAF1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 1:205,831,428...205,865,106
Ensembl chr 1:205,831,336...205,865,106

G

desert hedgehog signaling molecule

affects expression

EXP

Cocaine affects the expression of DHH mRNA

NCBI chr 7:131,929,857...131,935,352
Ensembl chr 7:131,929,857...131,935,352

G

DExH-box helicase 30

affects expression

EXP

Cocaine affects the expression of DHX30 mRNA

NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:118,943,187...118,975,592

G

divergent protein kinase domain 1B

affects expression

EXP

Cocaine affects the expression of DIPK1B mRNA

NCBI chr 3:29,852,710...29,862,248
Ensembl chr 3:29,853,973...29,862,255

G

discs large MAGUK scaffold protein 2

increases expression

EXP

Cocaine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

discs large MAGUK scaffold protein 4

affects expression
increases expression
multiple interactions
decreases response to substance
decreases expression

EXP
ISO

Cocaine affects the expression of DLG4 mRNA; Cocaine affects the expression of DLG4 protein
Cocaine results in increased expression of DLG4 protein
ILK mutant form inhibits the reaction [Cocaine results in increased expression of DLG4 protein]
DLG4 protein results in decreased susceptibility to Cocaine
Cocaine results in decreased expression of DLG4 mRNA

PMID:14980210 PMID:19629758 PMID:20187946 PMID:20534846 PMID:20600170

NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839

G

delta like non-canonical Notch ligand 2

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of DLK2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of DLK2 mRNA]

NCBI chr 9:22,174,667...22,179,149
Ensembl chr 9:22,173,158...22,179,149

G

dynein, axonemal, heavy chain 8

affects response to substance

ISO

DNAH8 gene SNP affects the susceptibility to Cocaine

NCBI chr20:8,694,371...8,948,849
Ensembl chr20:8,694,398...8,948,849

G

dynamin 1

affects expression

EXP

Cocaine affects the expression of DNM1 mRNA

NCBI chr 3:36,002,535...36,055,220
Ensembl chr 3:36,002,064...36,046,289

G

dynamin 1-like

multiple interactions
increases phosphorylation

EXP
ISO

[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to DNM1L promoter]
Cocaine results in increased phosphorylation of DNM1L protein

PMID:30158054 PMID:31494168

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

dynamin 2

affects expression

EXP

Cocaine affects the expression of DNM2 mRNA

NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:28,254,529...28,336,295

G

dynamin 3

affects expression

EXP

Cocaine affects the expression of DNM3 mRNA

NCBI chr13:76,892,381...77,371,346
Ensembl chr13:76,892,171...77,371,350

G

dynamin binding protein

decreases expression

EXP

Cocaine results in decreased expression of DNMBP mRNA

NCBI chr 1:252,685,406...252,778,642
Ensembl chr 1:252,685,406...252,778,688

G

DNA methyltransferase 3 beta

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of DNMT3B mRNA; Cocaine results in decreased expression of DNMT3B protein
Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B mRNA]; Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B protein]

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

ISO

Cocaine results in decreased expression of DNPH1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:21,978,894...21,981,631

G

double PHD fingers 2

increases expression

ISO

Cocaine results in increased expression of DPF2 mRNA

NCBI chr 1:212,612,986...212,628,376
Ensembl chr 1:212,612,986...212,628,289

G

dihydropyrimidinase-like 2

multiple interactions

EXP

[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065

G

dihydropyrimidinase-like 3

affects expression

EXP

Cocaine affects the expression of DPYSL3 mRNA

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

dopamine receptor D1

multiple interactions
affects expression
increases expression
decreases expression
affects response to substance
increases response to substance
decreases response to substance

ISO
EXP

1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein]; Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
Cocaine affects the expression of DRD1 protein
Cocaine deficiency results in increased expression of DRD1 mRNA
Cocaine results in decreased expression of DRD1 protein
DRD1 protein affects the susceptibility to Cocaine
DRD1 results in increased susceptibility to Cocaine
DRD1 gene mutant form results in decreased susceptibility to Cocaine
Cocaine promotes the reaction [DRD1 protein results in increased expression of FOS protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]; Cocaine promotes the reaction [DRD1 protein results in increased expression of SYT7 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
[anhydroecgonine methyl ester co-treated with Cocaine] results in decreased expression of DRD1 protein; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine affects the reaction [SCH 23390 binds to DRD1 protein]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]

PMID:2213551 PMID:8001143 PMID:11421588 PMID:11602327 PMID:15049517 More...

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

decreases expression
increases expression
affects response to substance
increases activity
multiple interactions
affects expression
decreases response to substance
increases response to substance

ISO
EXP

Cocaine results in decreased expression of DRD2 mRNA; Cocaine results in decreased expression of DRD2 protein
Cocaine deficiency results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Cocaine
Cocaine results in increased activity of DRD2 protein
Cocaine results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 protein
Cocaine affects the reaction [Spiperone binds to DRD2 protein]; Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]
Cocaine affects the expression of DRD2; Cocaine affects the expression of DRD2 mRNA; Cocaine affects the expression of DRD2 protein
DRD2 protein results in decreased susceptibility to Cocaine
PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]
DRD2 results in increased susceptibility to Cocaine
DRD2 polymorphism results in increased susceptibility to Cocaine
Cocaine affects the reaction [Raclopride binds to DRD2]

PMID:2213551 PMID:9892293 PMID:11126397 PMID:11602327 PMID:11790512 More...

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

decreases expression
decreases response to substance
increases expression
increases activity
affects expression
affects activity
multiple interactions
affects response to substance

ISO
EXP

Cocaine results in decreased expression of DRD3 protein
DRD3 results in decreased susceptibility to Cocaine
Cocaine results in increased expression of DRD3 mRNA
Cocaine results in increased activity of DRD3 protein
Cocaine affects the expression of DRD3 protein
Cocaine affects the activity of DRD3 protein
DRD3 protein results in decreased susceptibility to Cocaine
7-hydroxy-2-N,N-dipropylaminotetralin inhibits the reaction [Cocaine affects the activity of DRD3 protein]; Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]
DRD3 affects the susceptibility to Cocaine
[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine; [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol co-treated with Cocaine] affects the localization of DRD3 protein; Cocaine promotes the reaction [DRD3 protein results in decreased expression of FOS protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of NEO1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of PDYN protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of SYT7 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of PDYN protein]; SB 277011 inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine]

PMID:10523822 PMID:10943692 PMID:11120399 PMID:12099907 PMID:15056714 More...

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

dopamine receptor D4

increases response to substance
affects expression

ISO
EXP

DRD4 polymorphism results in increased susceptibility to Cocaine
Cocaine affects the expression of DRD4 mRNA

PMID:17671965 PMID:20187946

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458

G

dopamine receptor D5

affects expression

EXP

Cocaine affects the expression of DRD5 mRNA

NCBI chr14:76,700,244...76,703,344
Ensembl chr14:76,700,241...76,703,466

G

dystrophin related protein 2

affects expression

ISO

Cocaine affects the expression of DRP2 protein

NCBI chr X:101,900,743...101,951,403
Ensembl chr X:101,901,011...101,951,403

G

desmoplakin

increases expression

ISO

Cocaine results in increased expression of DSP protein

NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121

G

dual specificity phosphatase 1

affects expression
increases phosphorylation

EXP

Cocaine affects the expression of DUSP1 mRNA
Cocaine results in increased phosphorylation of DUSP1 protein

PMID:18822274 PMID:20187946

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 5

affects expression
increases expression

EXP

Cocaine affects the expression of CPG21 mRNA
Cocaine results in increased expression of DUSP5 mRNA

PMID:20187946 PMID:27899881

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 8

multiple interactions
increases expression

EXP

5,7-Dihydroxytryptamine inhibits the reaction [Cocaine results in increased expression of DUSP8 mRNA]

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:206,598,942...206,612,441

G

dishevelled segment polarity protein 1

affects expression

EXP

Cocaine affects the expression of DVL1 mRNA

NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:171,739,133...171,750,966

G

dynein cytoplasmic 1 intermediate chain 1

decreases expression

ISO

Cocaine results in decreased expression of DYNC1I1 mRNA

NCBI chr 4:34,819,313...35,132,647
Ensembl chr 4:34,819,430...35,142,319

G

dynein, cytoplasmic 1 light intermediate chain 2

increases expression

EXP

Cocaine results in increased expression of DYNC1LI2 protein

NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107

G

dynein light chain LC8-type 1

affects expression

EXP

Cocaine affects the expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

enoyl-CoA delta isomerase 2

affects expression

EXP

Cocaine affects the expression of ECI2 mRNA

NCBI chr17:30,056,274...30,092,169
Ensembl chr17:30,076,524...30,092,161

G

endothelin 1

increases expression

EXP
ISO

Cocaine results in increased expression of EDN1 protein

PMID:9714087 PMID:11948058 PMID:17420087 PMID:18813882

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

increases expression

ISO
EXP

Cocaine results in increased expression of EDNRA protein

PMID:17420087 PMID:18813882

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

endothelin receptor type B

affects expression

EXP

Cocaine affects the expression of EDNRB mRNA

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

eukaryotic translation elongation factor 1 alpha 1

affects expression

EXP

Cocaine affects the expression of EEF1A1 mRNA

NCBI chr 8:88,221,839...88,225,688
Ensembl chr 8:88,221,843...88,225,072

G

eukaryotic translation elongation factor 1 alpha 2

affects expression

EXP

Cocaine affects the expression of EEF1A2 mRNA

NCBI chr 3:188,643,455...188,652,633
Ensembl chr 3:188,643,458...188,677,712

G

eukaryotic translation elongation factor 1 gamma

decreases expression

ISO

Cocaine results in decreased expression of EEF1G mRNA

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

EF-hand calcium binding domain 3

affects expression
decreases expression

EXP

Cocaine affects the expression of EFCAB3 mRNA
Cocaine results in decreased expression of EFCAB3 mRNA

PMID:17898221 PMID:20187946

NCBI chr10:90,084,495...90,577,145
Ensembl chr10:90,084,397...90,577,144

G

ephrin A1

affects expression

EXP

Cocaine affects the expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

ephrin A2

affects expression

EXP

Cocaine affects the expression of EFNA2 mRNA

NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:10,167,091...10,177,719

G

ephrin A3

affects expression

EXP

Cocaine affects the expression of EFNA3 mRNA

NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:177,026,933...177,044,843

G

ephrin A4

affects expression

EXP

Cocaine affects the expression of EFNA4 mRNA

NCBI chr 2:177,046,463...177,050,713
Ensembl chr 2:177,046,463...177,050,713

G

ephrin A5

increases expression

EXP

Cocaine results in increased expression of EFNA5 mRNA

NCBI chr 9:109,763,786...110,042,396
Ensembl chr 9:109,767,252...110,042,348

G

ephrin B1

increases expression

EXP

Cocaine results in increased expression of EFNB1 mRNA

PMID:15691709 PMID:17898221

NCBI chr X:68,297,529...68,310,335
Ensembl chr X:68,297,492...68,349,546

G

ephrin B2

increases expression

EXP

Cocaine results in increased expression of EFNB2 mRNA

NCBI chr16:87,485,215...87,529,224
Ensembl chr16:87,485,198...87,529,208

G

ephrin B3

increases expression

EXP

Cocaine results in increased expression of EFNB3 mRNA

NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,773,282...54,797,651

G

elongation factor Tu GTP binding domain containing 2

affects expression

EXP

Cocaine affects the expression of EFTUD2 mRNA

NCBI chr10:88,304,992...88,352,229
Ensembl chr10:88,304,992...88,346,299

G

epidermal growth factor receptor

decreases expression

ISO

Cocaine results in decreased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

affects expression
decreases expression
increases expression
multiple interactions
increases response to substance

ISO
EXP

Cocaine affects the expression of EGR1 mRNA
Cocaine deficiency results in decreased expression of EGR1 mRNA
Cocaine results in increased expression of EGR1 protein
NPPC protein inhibits the reaction [Cocaine results in increased expression of EGR1 mRNA]
Cocaine results in increased expression of EGR1 mRNA; Cocaine results in increased expression of EGR1 protein
EGR1 results in increased susceptibility to Cocaine
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]

PMID:1347779 PMID:7905595 PMID:9890435 PMID:10971643 PMID:11860464 More...

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

increases expression
affects expression

ISO
EXP

Cocaine results in increased expression of EGR2 mRNA
Cocaine affects the expression of EGR2 mRNA

PMID:20056891 PMID:20187946 PMID:27899881

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

early growth response 3

affects expression
decreases expression
multiple interactions
increases expression

EXP
ISO

Cocaine affects the expression of EGR3 mRNA
Cocaine deficiency results in decreased expression of EGR3 mRNA
[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to EGR3 promoter]
Cocaine results in increased expression of EGR3 mRNA

PMID:16459018 PMID:20187946 PMID:27126842 PMID:30158054

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

early growth response 4

increases expression

EXP

Cocaine results in increased expression of EGR4 mRNA

NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368

G

EH-domain containing 2

decreases expression

EXP

Cocaine results in decreased expression of EHD2 mRNA

NCBI chr 1:85,767,757...85,786,974
Ensembl chr 1:85,768,667...85,786,943

G

euchromatic histone lysine methyltransferase 1

decreases expression

ISO

Cocaine results in decreased expression of EHMT1 mRNA

NCBI chr 3:27,978,888...28,127,178
Ensembl chr 3:27,978,888...28,127,349

G

euchromatic histone lysine methyltransferase 2

multiple interactions
decreases response to substance
decreases expression

ISO

Cocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]; Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]; EHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of ELMO1 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of TGFBR1 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of TNFRSF25 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of USP9X mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of WNK3 mRNA]; EHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]
EHMT2 results in decreased susceptibility to Cocaine
Cocaine results in decreased expression of EHMT2 mRNA; Cocaine results in decreased expression of EHMT2 protein

NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,924,263...3,941,384

G

eukaryotic translation initiation factor 1A

increases expression

EXP

Cocaine results in increased expression of EIF1A mRNA; Cocaine results in increased expression of EIF1AY mRNA

NCBI chr18:41,512,298...41,524,645
Ensembl chr18:41,503,180...41,549,696

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

EXP

Cocaine results in increased expression of EIF2AK3 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

EXP

Cocaine results in increased phosphorylation of EIF2S1

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 3, subunit A

increases expression

EXP

Cocaine results in increased expression of EIF3A mRNA

NCBI chr 1:269,888,730...269,925,785
Ensembl chr 1:269,888,615...269,919,025

G

eukaryotic translation initiation factor 3, subunit B

affects expression

EXP

Cocaine affects the expression of EIF3B mRNA

NCBI chr12:19,310,308...19,334,768
Ensembl chr12:19,310,311...19,334,939

G

eukaryotic translation initiation factor 3, subunit C

increases expression

EXP

Cocaine results in increased expression of EIF3C mRNA

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 3 subunit E

affects expression

EXP

Cocaine affects the expression of EIF3E mRNA

NCBI chr 7:76,224,567...76,257,346
Ensembl chr 7:76,224,568...76,257,785

G

eukaryotic translation initiation factor 4B

multiple interactions
increases expression

ISO

FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of EIF4B mRNA]

NCBI chr 7:135,085,259...135,107,054
Ensembl chr 7:135,085,066...135,107,064

G

eukaryotic translation initiation factor 5A

decreases expression
affects expression
increases expression

ISO
EXP

Cocaine results in decreased expression of EIF5A mRNA
Cocaine affects the expression of EIF5A mRNA
Cocaine results in increased expression of EIF5A mRNA

PMID:15009677 PMID:16710320 PMID:20187946

NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330

G

eukaryotic translation initiation factor 5B

increases expression

EXP

Cocaine results in increased expression of EIF5B mRNA

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583

G

eukaryotic translation initiation factor 5B, pseudogene 1

increases expression

EXP

Cocaine results in increased expression of EIF5B-PS1 mRNA

NCBI chr19:52,297,623...52,301,730

G

elastase, neutrophil expressed

multiple interactions

ISO

[Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]] which results in decreased activity of ELANE protein; Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]

NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725

G

engulfment and cell motility 1

multiple interactions
increases expression

ISO

EHMT2 inhibits the reaction [Cocaine results in increased expression of ELMO1 mRNA]

NCBI chr17:48,982,188...49,518,525
Ensembl chr17:48,982,188...49,518,159

G

ER membrane protein complex subunit 9

affects expression

EXP

Cocaine affects the expression of EMC9 mRNA

NCBI chr15:33,041,840...33,046,056
Ensembl chr15:33,041,842...33,046,102

G

ENAH, actin regulator

increases expression

EXP

Cocaine results in increased expression of ENAH mRNA

NCBI chr13:96,149,437...96,269,841
Ensembl chr13:96,149,437...96,269,796

G

ectodermal-neural cortex 1

increases expression

EXP

Cocaine results in increased expression of ENC1 mRNA

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

energy homeostasis associated

decreases expression

ISO

Cocaine results in decreased expression of ENHO mRNA

NCBI chr 5:61,596,860...61,598,657
Ensembl chr 5:61,596,860...61,598,657

G

enolase 2

decreases expression
increases expression

ISO

Cocaine results in decreased expression of ENO2 mRNA
Cocaine results in increased expression of ENO2 protein

PMID:12629581 PMID:17075605

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

increases expression

ISO

Cocaine results in increased expression of ENPP5 mRNA

NCBI chr 9:24,407,574...24,415,029
Ensembl chr 9:24,408,218...24,414,867

G

ectonucleoside triphosphate diphosphohydrolase 2

decreases expression

EXP

Cocaine results in decreased expression of ENTPD2 protein

NCBI chr 3:28,611,722...28,617,237
Ensembl chr 3:28,611,772...28,618,184

G

ectonucleoside triphosphate diphosphohydrolase 3

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ENTPD3 mRNA

NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:129,124,709...129,156,252

G

Eph receptor A1

affects expression

EXP

Cocaine affects the expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

Eph receptor A2

affects expression

EXP

Cocaine affects the expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234

G

Eph receptor A3

affects expression

EXP

Cocaine affects the expression of EPHA3 mRNA

NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425

G

Eph receptor A4

affects expression
increases expression

EXP

Cocaine affects the expression of EPHA4 mRNA
Cocaine results in increased expression of EPHA4 mRNA

PMID:15691709 PMID:17898221

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

EPH receptor A5

affects expression

EXP

Cocaine affects the expression of EPHA5 mRNA

NCBI chr14:24,007,400...24,374,854
Ensembl chr14:24,008,122...24,374,848

G

Eph receptor A7

affects expression

EXP

Cocaine affects the expression of EPHA7 mRNA

NCBI chr 5:47,771,776...47,925,189
Ensembl chr 5:47,771,865...47,925,058

G

Eph receptor A8

affects expression

EXP

Cocaine affects the expression of EPHA8 mRNA

NCBI chr 5:154,449,566...154,476,966
Ensembl chr 5:154,449,566...154,476,966

G

Eph receptor B1

increases expression

ISO
EXP

Cocaine results in increased expression of EPHB1 protein
Cocaine results in increased expression of EPHB1 mRNA

PMID:11146119 PMID:15691709

NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:111,386,432...111,823,759

G

Eph receptor B2

increases expression

EXP

Cocaine results in increased expression of EPHB2 mRNA

NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:154,179,065...154,360,615

G

Eph receptor B3

affects expression

EXP

Cocaine affects the expression of EPHB3 mRNA

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775

G

EPH receptor B4

decreases expression
affects expression

ISO
EXP

Cocaine results in decreased expression of EPHB4 mRNA
Cocaine affects the expression of EPHB4 mRNA

PMID:15691709 PMID:18000554

NCBI chr12:24,963,174...24,988,473
Ensembl chr12:24,963,174...24,988,388

G

Eph receptor B6

affects expression

EXP

Cocaine affects the expression of EPHB6 mRNA

NCBI chr 4:71,458,632...71,473,889
Ensembl chr 4:71,458,971...71,476,659

G

erbb2 interacting protein

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of ERBIN mRNA]

NCBI chr 2:36,660,399...36,762,584
Ensembl chr 2:36,660,399...36,762,153

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

EXP

6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of ERN1 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of ERN1 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

ess-2 splicing factor homolog

decreases expression

EXP

Cocaine results in decreased expression of ESS2 mRNA

NCBI chr11:96,580,185...96,596,673
Ensembl chr11:96,580,169...96,590,146

G

eukaryotic translation termination factor 1

affects expression

EXP

Cocaine affects the expression of ETF1 mRNA

NCBI chr18:26,776,518...26,804,857
Ensembl chr18:26,777,858...26,804,613

G

electron transfer flavoprotein subunit alpha

affects expression

EXP

Cocaine affects the expression of ETFA mRNA

NCBI chr 8:64,731,192...64,787,965
Ensembl chr 8:64,731,193...64,788,080

G

exocyst complex component 2

increases expression

EXP

Cocaine results in increased expression of EXOC2 protein

NCBI chr17:33,714,949...33,906,901
Ensembl chr17:33,715,008...33,901,944

G

EYA transcriptional coactivator and phosphatase 1

increases expression

ISO

Cocaine results in increased expression of EYA1 mRNA

NCBI chr 5:9,646,599...9,884,609
Ensembl chr 5:9,646,591...9,884,614

G

EYA transcriptional coactivator and phosphatase 2

affects expression

EXP

Cocaine affects the expression of EYA2 mRNA

NCBI chr 3:174,754,772...174,938,035
Ensembl chr 3:174,818,554...174,938,034

G

ezrin

decreases expression

ISO

Cocaine results in decreased expression of EZR mRNA

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

Fas associated via death domain

affects expression
multiple interactions
decreases expression

EXP

Cocaine affects the expression of FADD mRNA
Raclopride affects the reaction [Cocaine affects the expression of FADD protein]
Cocaine results in decreased expression of FADD protein modified form

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

fumarylacetoacetate hydrolase domain containing 1

increases expression

EXP

Cocaine results in increased expression of FAHD1 protein

NCBI chr10:14,378,058...14,379,497
Ensembl chr10:14,378,120...14,379,867

G

fumarylacetoacetate hydrolase domain containing 2A

affects expression

ISO

Cocaine affects the expression of FAHD2A protein

NCBI chr 3:135,110,480...135,118,653
Ensembl chr 3:135,109,482...135,118,853

G

Fas apoptotic inhibitory molecule

affects expression

ISO

Cocaine affects the expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

Fas apoptotic inhibitory molecule 2

increases expression

EXP

Cocaine results in increased expression of FAIM2 mRNA

NCBI chr 7:132,512,095...132,539,192
Ensembl chr 7:132,512,210...132,538,026

G

family with sequence similarity 184, member B

decreases expression

EXP

Cocaine results in decreased expression of FAM184B mRNA

NCBI chr14:69,688,031...69,803,922
Ensembl chr14:69,688,031...69,803,922

G

FAM20C, golgi associated secretory pathway kinase

affects expression

EXP

Cocaine affects the expression of FAM20C mRNA

NCBI chr12:20,940,654...20,999,072
Ensembl chr12:20,940,654...20,998,318

G

family with sequence similarity 78, member B

decreases expression

EXP

Cocaine results in decreased expression of FAM78B mRNA

NCBI chr13:81,695,329...81,783,881
Ensembl chr13:81,695,329...81,781,784

G

family with sequence similarity 89, member B

affects expression

EXP

Cocaine affects the expression of MTVR2 mRNA

NCBI chr 1:212,445,101...212,447,164
Ensembl chr 1:212,445,102...212,446,738

G

Fas cell surface death receptor

increases expression

ISO

Cocaine results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box and leucine-rich repeat protein 3

increases expression

EXP

Cocaine results in increased expression of FBXL3 mRNA

NCBI chr15:86,321,504...86,341,387
Ensembl chr15:86,321,504...86,341,387

G

F-box protein 46

affects expression

EXP

Cocaine affects the expression of FBXO46 mRNA

NCBI chr 1:87,898,029...87,914,615
Ensembl chr 1:87,897,888...87,926,021

G

Fc gamma receptor 2B

decreases expression

EXP

Cocaine results in decreased expression of FCGR2B mRNA

NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517

G

farnesyl diphosphate farnesyl transferase 1

increases expression

ISO

Cocaine results in increased expression of FDFT1 mRNA

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168

G

FEV transcription factor, ETS family member

decreases expression

EXP

Cocaine results in decreased expression of FEV mRNA

NCBI chr 9:83,887,844...83,891,718
Ensembl chr 9:83,887,844...83,891,737

G

FYVE, RhoGEF and PH domain containing 5

increases expression

EXP

Cocaine results in increased expression of FGD5 mRNA

NCBI chr 4:126,054,201...126,151,698
Ensembl chr 4:126,054,210...126,151,697

G

fibroblast growth factor 12

affects expression

EXP

Cocaine affects the expression of FGF12 mRNA

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 2

decreases expression

ISO

Cocaine results in decreased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

Fibroblast growth factor receptor 1

increases expression

EXP

Cocaine results in increased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

fumarate hydratase

affects expression

ISO

Cocaine affects the expression of FH1 protein

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

fission, mitochondrial 1

increases expression

ISO

Cocaine results in increased expression of FIS1 mRNA

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

FKBP prolyl isomerase 1B

affects expression

EXP

Cocaine affects the expression of FKBP1B mRNA

NCBI chr 6:33,551,583...33,570,055
Ensembl chr 6:33,558,517...33,568,129

G

FKBP prolyl isomerase 5

increases expression

EXP

cocaine increases expression of Fkbp5 mRNA in bed nucleus of the stria terminalis, central amygdala and paraventricular nucleus

RGD

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

FKBP prolyl isomerase like

affects expression

EXP

Cocaine affects the expression of FKBPL mRNA

NCBI chr20:4,104,457...4,105,927
Ensembl chr20:4,104,019...4,105,615

G

fibronectin leucine rich transmembrane protein 3

increases expression

ISO

Cocaine results in increased expression of FLRT3 mRNA

NCBI chr 3:148,448,115...148,461,458
Ensembl chr 3:148,439,354...148,461,650

G

FLYWCH-type zinc finger 1

decreases expression

EXP

Cocaine results in decreased expression of FLYWCH1 mRNA

NCBI chr10:13,279,232...13,298,955
Ensembl chr10:13,279,232...13,298,925

G

fragile X messenger ribonucleoprotein 1

decreases expression

EXP

Cocaine results in decreased expression of FMR1 mRNA

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675

G

fibronectin type III domain containing 1

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of FNDC1 mRNA

NCBI chr 1:49,686,856...49,769,263
Ensembl chr 1:49,686,856...49,769,263

G

fibronectin type III domain containing 5

affects expression

EXP

Cocaine affects the expression of FNDC5 mRNA

NCBI chr 5:146,765,951...146,775,611
Ensembl chr 5:146,751,416...146,778,540

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
affects expression
increases phosphorylation
decreases response to substance
increases activity
decreases expression

ISO
EXP

[Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Cocaine results in increased expression of FOS mRNA; Cocaine results in increased expression of FOS protein
Cocaine affects the expression of FOS mRNA; Cocaine affects the expression of FOS protein
Cocaine results in increased phosphorylation of FOS protein
[Morphine co-treated with Cocaine] affects the expression of FOS; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; Alcohols promotes the reaction [Cocaine results in increased expression of FOS protein]; Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein]; Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of FOS protein]; Cocaine promotes the reaction [Cocaine results in increased expression of FOS mRNA]; Cocaine promotes the reaction [Ethanol results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; ecopipam inhibits the reaction [Cocaine results in increased expression of FOS protein]; Ethanol promotes the reaction [Cocaine results in increased expression of FOS protein]; Muscimol inhibits the reaction [Cocaine results in increased expression of FOS protein]; NPPC protein inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOS protein]; Urethane inhibits the reaction [Cocaine results in increased expression of FOS protein]; volinanserin inhibits the reaction [Cocaine results in increased expression of FOS protein]
FOS protein mutant form results in decreased susceptibility to Cocaine
Cocaine results in increased activity of FOS protein
Cocaine deficiency results in decreased expression of FOS protein; Cocaine results in decreased expression of FOS protein
[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of SYT7 protein; [Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ATPAF1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of CD4 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of CORO7 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ENTPD3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of FNDC1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ITPR1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of NEXN mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PBX2 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PER1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PKNOX2 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PLPP1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PRKCZ mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of SHANK3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of SYT9 mRNA; [Cocaine co-treated with FOS protein mutant form] results in decreased expression of THRA mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of ADGRA1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of CAB39L mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of CAMK1G mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of CBLN1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of GRIP1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of INA mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of LARGE1 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of NRIP3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of SATB2 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of SORCS3 mRNA; [Cocaine co-treated with FOS protein mutant form] results in increased expression of TENM4 mRNA; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein; Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein]; CDK5R1 protein inhibits the reaction [Cocaine affects the expression of FOS mRNA]; CDK5R1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased expression of FOS protein]; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]; Cocaine promotes the reaction [DRD1 protein results in increased expression of FOS protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of FOS protein]; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Cocaine results in increased expression of FOS protein]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of BDNF mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of CALR mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of DLK2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HOMER2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HS3ST2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of MAPK11 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NCALD mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NPTXR mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NRN1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of PRKCA mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SATB1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SEZ6L mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP1B3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP8B2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CLK1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CTSB mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of EIF4B mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of GPC5 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KCNT1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KDM3A mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LIN7B mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LZTS3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of MEPCE mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NIT2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NOS3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PBX3 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PPP1R7 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PRPF18 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PTPRV mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SBSN mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYNE1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYT2 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of TSPOAP1 mRNA]; FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ZFPM1 mRNA]; GPX1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOS protein]; N-methyl-3-(bis(4'-fluorophenyl)methoxy)tropane inhibits the reaction [Cocaine results in increased expression of FOS protein]; NTRK2 protein affects the reaction [Cocaine affects the expression of FOS protein]; prolinedithiocarbamate inhibits the reaction [Cocaine results in increased expression of FOS protein]; RPS6KA3 affects the reaction [Cocaine results in increased phosphorylation of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased activity of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS protein]

PMID:1498673 PMID:2118661 PMID:7905595 PMID:10415707 PMID:10521585 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
increases expression
multiple interactions
affects expression

ISO
EXP

Cocaine results in increased expression of FOSB protein
cocaine increases expression of Fosb protein in dorsal striatum and nucelus accumbens
Cocaine increases expression of Fosb mRNA and protein in Nucleus Accumbens and Caudate Putamen
Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamen
Cocaine increases expression of Fosb protein in caudate��putamen
Cocaine increases expression of Fosb protein in brain
cocaine increases expression of Fosb protein in Brain
cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate Putamen
DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein]
Cocaine results in increased expression of FOSB mRNA; Cocaine results in increased expression of FOSB protein; Cocaine results in increased expression of FOSB protein alternative form
Cocaine affects the expression of FOSB mRNA; Cocaine affects the expression of FOSB protein
[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein; [JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine; Cocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]; Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]; EHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; PPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]

CTD
RGD

PMID:10103106 PMID:11391778 PMID:11739600 PMID:12417638 PMID:15056714 More...

RGD:401901287, RGD:401900126, RGD:401900166, RGD:401900302, RGD:401851084, RGD:401851078, RGD:401851063

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

FOS like 1, AP-1 transcription factor subunit

affects expression
decreases expression

EXP
ISO

Cocaine affects the expression of FOSL1 mRNA
Cocaine results in decreased expression of FOSL1 mRNA

PMID:12117546 PMID:12629581

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions
decreases expression

ISO

Cocaine promotes the reaction [JUN protein binds to FOSL2 protein]
[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]
Cocaine results in decreased expression of FOSL2 protein

PMID:15056714 PMID:15814102

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box C2

decreases expression

EXP

Cocaine results in decreased expression of FOXC2 mRNA

NCBI chr19:66,094,718...66,097,420
Ensembl chr19:66,094,700...66,153,977

G

forkhead box O1

decreases expression

EXP

Cocaine results in decreased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box P1

increases expression

ISO

Cocaine deficiency results in increased expression of FOXP1 mRNA

NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272

G

Fraser extracellular matrix complex subunit 1

increases expression

EXP

Cocaine results in increased expression of FRAS1 mRNA

NCBI chr14:13,095,370...13,506,895
Ensembl chr14:13,095,370...13,504,664

G

FRAS1 related extracellular matrix 2

decreases expression

EXP

Cocaine results in decreased expression of FREM2 mRNA

NCBI chr 2:139,753,055...139,891,046
Ensembl chr 2:139,753,055...139,891,046

G

FERM domain containing 5

decreases expression

EXP

Cocaine results in decreased expression of FRMD5 mRNA

NCBI chr 3:128,945,812...129,217,134
Ensembl chr 3:128,927,671...129,217,074

G

fibroblast growth factor receptor substrate 3

affects expression

EXP

Cocaine affects the expression of FRS3 mRNA

NCBI chr 9:20,786,096...20,800,905
Ensembl chr 9:20,786,096...20,794,761

G

FRY like transcription coactivator

increases expression

ISO

cocaine increases expression of Fryl mRNA in nucleus accumbens

RGD

NCBI chr14:35,307,225...35,545,199
Ensembl chr14:35,310,656...35,545,147

G

far upstream element binding protein 1

affects expression

EXP

Cocaine affects the expression of FUBP1 mRNA

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:243,819,218...243,846,428

G

fucosyltransferase 8

affects expression

EXP

Cocaine affects the expression of FUT8 mRNA

NCBI chr 6:101,682,354...101,909,784
Ensembl chr 6:101,683,007...101,909,775

G

frizzled class receptor 6

affects expression

EXP

Cocaine affects the expression of FZD6 mRNA

NCBI chr 7:71,939,916...71,971,685
Ensembl chr 7:71,939,973...71,971,680

G

glucose-6-phosphate dehydrogenase

increases expression

EXP

Cocaine results in increased expression of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

gamma-aminobutyric acid type B receptor subunit 1

affects expression
increases expression
decreases expression

EXP

Cocaine affects the expression of GABBR1 mRNA
Cocaine results in increased expression of GABBR1 mRNA
Cocaine results in decreased expression of GABBR1 mRNA

PMID:11793422 PMID:16076954 PMID:20187946

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607

G

gamma-aminobutyric acid type B receptor subunit 2

decreases phosphorylation

EXP

Cocaine results in decreased phosphorylation of GABBR2 protein

NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:65,743,073...66,083,695

G

gamma-aminobutyric acid type A receptor subunit alpha 1

affects expression
multiple interactions

EXP
ISO

Cocaine affects the expression of GABRA1 protein
Cocaine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

PMID:20826313 PMID:23266428 PMID:32209479

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

EXP

Cocaine results in increased expression of GABRB1 mRNA

NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,434,352...36,902,893

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

ISO
EXP

1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
Cocaine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

PMID:23266428 PMID:32209479

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171

G

gamma-aminobutyric acid type A receptor subunit beta 3

affects expression
multiple interactions

EXP

Cocaine affects the expression of GABRB3 mRNA
Cocaine affects the phosphorylation of and affects the expression of GABRB3 protein

PMID:20187946 PMID:20826313

NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:117,431,842...117,836,725

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions
increases expression

ISO
EXP

1-(3-chlorophenyl)piperazine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,4-Methylenedioxyamphetamine promotes the reaction [Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [1-(3-chlorophenyl)piperazine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine promotes the reaction [3,4-Methylenedioxyamphetamine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Cocaine results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
Cocaine deficiency results in increased expression of GABRG2 mRNA
Cocaine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]

PMID:23266428 PMID:27126842 PMID:32209479

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523

G

glutamate decarboxylase 1

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of GAD1 mRNA
Cocaine results in increased expression of GAD1 protein

PMID:12629581 PMID:15295023 PMID:18611417

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

galanin and GMAP prepropeptide

multiple interactions

ISO

GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

galactokinase 1

affects expression

EXP

Cocaine affects the expression of GALK1 mRNA

NCBI chr10:101,742,067...101,746,244
Ensembl chr10:101,735,061...101,746,258

G

polypeptide N-acetylgalactosaminyltransferase 1

increases expression

EXP

Cocaine results in increased expression of GALNT1 mRNA

NCBI chr18:15,763,697...15,843,598
Ensembl chr18:15,764,277...15,843,588

G

polypeptide N-acetylgalactosaminyltransferase 16

affects expression

EXP

Cocaine affects the expression of GALNT16 mRNA

NCBI chr 6:105,900,987...105,982,039
Ensembl chr 6:105,901,153...105,991,350

G

growth associated protein 43

decreases expression

ISO

Cocaine results in decreased expression of GAP43 mRNA

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

growth arrest-specific 2

affects expression

ISO

Cocaine affects the expression of GAS2 mRNA

NCBI chr 1:110,587,952...110,721,572
Ensembl chr 1:110,717,312...110,718,541

G

GRIP and coiled-coil domain containing 1

increases expression

ISO

Cocaine results in increased expression of GCC1 mRNA

NCBI chr 4:57,996,261...58,008,126
Ensembl chr 4:57,996,267...58,002,185

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO

Cocaine results in increased expression of GCLC mRNA
PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

affects expression
increases expression
multiple interactions

EXP
ISO

Cocaine affects the expression of GCLM mRNA
Cocaine results in increased expression of GCLM mRNA
PRKCD protein affects the reaction [Cocaine results in increased expression of GCLM mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLM mRNA]

PMID:20187946 PMID:30393195

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glucosaminyl (N-acetyl) transferase 2

increases expression

ISO

Cocaine deficiency results in increased expression of GCNT2 mRNA

NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989

G

ganglioside-induced differentiation-associated-protein 1

increases expression

EXP

Cocaine results in increased expression of GDAP1 protein

NCBI chr 5:6,715,935...6,735,013
Ensembl chr 5:6,715,935...6,735,313

G

ganglioside-induced differentiation-associated protein 1-like 1

decreases expression

EXP

Cocaine results in decreased expression of GDAP1L1 protein

NCBI chr 3:172,529,523...172,549,128
Ensembl chr 3:172,509,564...172,549,125

G

glial cell derived neurotrophic factor

decreases expression

EXP

Cocaine results in decreased expression of GDNF mRNA

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240

G

GTP binding protein overexpressed in skeletal muscle

increases expression

ISO

Cocaine results in increased expression of GEM mRNA

NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542

G

glial fibrillary acidic protein

increases expression
decreases expression
affects expression

ISO
EXP

Cocaine results in increased expression of GFAP protein
Cocaine results in decreased expression of GFAP protein
Cocaine affects the expression of GFAP mRNA; Cocaine affects the expression of GFAP protein

PMID:11391778 PMID:11882367 PMID:12670315 PMID:15814102 PMID:20187946

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

GDNF family receptor alpha 2

affects expression

EXP

Cocaine affects the expression of GFRA2 mRNA

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782

G

growth hormone 1

multiple interactions

ISO
EXP

Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein]; Cocaine inhibits the reaction [Sodium Oxybate results in increased expression of GH1 protein]
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]

PMID:9413023 PMID:10657535 PMID:15099682

NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859

G

GID complex subunit 8 homolog

affects expression

EXP

Cocaine affects the expression of GID8 mRNA

NCBI chr 3:188,203,571...188,214,324
Ensembl chr 3:188,203,619...188,212,270

G

GTPase, IMAP family member 1

affects expression

EXP

Cocaine affects the expression of GIMAP1 mRNA

NCBI chr 4:79,018,473...79,022,360
Ensembl chr 4:79,018,202...79,022,525

G

GTPase, IMAP family member 5

affects expression

EXP

Cocaine affects the expression of GIMAP5 mRNA

NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:79,024,304...79,039,030

G

GINS complex subunit 3

decreases expression

EXP

Cocaine results in decreased expression of GINS3 mRNA

NCBI chr19:9,426,140...9,435,192
Ensembl chr19:9,399,759...9,434,679

G

GIPC PDZ domain containing family, member 1

affects expression

EXP

Cocaine affects the expression of GIPC1 mRNA

NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725

G

gap junction protein, alpha 5

increases expression

EXP

Cocaine results in increased expression of GJA5 mRNA

NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512

G

gap junction protein, beta 1

affects expression

EXP

Cocaine affects the expression of GJB1 mRNA; Cocaine affects the expression of GJB1 protein

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

gap junction protein, beta 2

decreases expression

ISO

Cocaine results in decreased expression of GJB2 mRNA

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877

G

gap junction protein, beta 5

decreases expression

EXP

Cocaine results in decreased expression of GJB5 mRNA

NCBI chr 5:144,965,133...144,968,051
Ensembl chr 5:144,964,751...144,984,021

G

gap junction protein, delta 2

affects expression

EXP

Cocaine affects the expression of GJD2 mRNA; Cocaine affects the expression of GJD2 protein

NCBI chr 3:121,226,372...121,229,367
Ensembl chr 3:121,226,368...121,230,603

G

GLI family zinc finger 2

decreases expression

EXP

Cocaine results in decreased expression of GLI2 mRNA

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418

G

glucagon-like peptide 2 receptor

decreases expression

EXP

Cocaine results in decreased expression of GLP2R mRNA

NCBI chr10:52,901,707...52,964,961
Ensembl chr10:52,900,706...52,964,961

G

glycine receptor, alpha 1

multiple interactions

EXP

Cocaine inhibits the reaction [Glycine results in increased activity of GLRA1 protein]; Dronabinol inhibits the reaction [Cocaine inhibits the reaction [Glycine results in increased activity of GLRA1 protein]]

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:40,130,121...40,227,815

G

glutaredoxin 3

affects expression

EXP

Cocaine affects the expression of GLRX3 mRNA

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

G protein subunit alpha o1

decreases expression
multiple interactions

ISO
EXP

Cocaine results in decreased expression of GNAO1 mRNA
[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of GNAO1 protein alternative form

PMID:12629581 PMID:19457111

NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,040,788...11,198,437

G

G protein subunit alpha transducin 1

increases expression

EXP

Cocaine results in increased expression of GNAT1 mRNA

NCBI chr 8:117,229,575...117,234,311
Ensembl chr 8:117,229,575...117,234,311

G

G protein subunit beta 1

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of GNB1 mRNA
Cocaine results in increased expression of GNB1 mRNA

PMID:12629581 PMID:16076954

NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488

G

G protein subunit beta 2

affects expression

EXP

Cocaine affects the expression of GNB2 mRNA

NCBI chr12:24,795,505...24,800,796
Ensembl chr12:24,795,827...24,800,796

G

G protein subunit beta 4

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of GNB4 mRNA]

NCBI chr 2:117,289,112...117,329,050
Ensembl chr 2:117,293,284...117,328,945

G

G protein subunit gamma 12

affects expression

EXP

Cocaine affects the expression of GNG12 mRNA

NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476

G

gonadotropin releasing hormone 1

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of GNRH1 protein
GPX1 protein inhibits the reaction [Cocaine results in decreased expression of GNRH1 protein]; prolinedithiocarbamate inhibits the reaction [Cocaine results in decreased expression of GNRH1 protein]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

glycoprotein 2

affects expression

EXP

Cocaine affects the expression of GP2 mRNA

NCBI chr 1:183,228,395...183,243,954
Ensembl chr 1:183,228,395...183,243,954

G

glypican 5

increases expression
multiple interactions

ISO

Cocaine results in increased expression of GPC5 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of GPC5 mRNA]

NCBI chr15:98,614,499...100,051,285
Ensembl chr15:98,646,340...100,051,514

G

G protein-coupled estrogen receptor 1

increases expression

EXP

Cocaine results in increased expression of GPER1 mRNA

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

gephyrin

increases phosphorylation
multiple interactions

EXP

Cocaine results in increased phosphorylation of GPHN protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased phosphorylation of GPHN protein]

NCBI chr 6:102,687,405...103,216,679
Ensembl chr 6:102,687,423...103,216,674

G

glycoprotein m6a

decreases expression

ISO

Cocaine results in decreased expression of GPM6A mRNA

NCBI chr16:43,374,385...43,706,461
Ensembl chr16:43,374,385...43,706,705

G

glycoprotein m6b

decreases expression

ISO

Cocaine results in decreased expression of GPM6B mRNA

NCBI chr X:31,689,485...31,836,199
Ensembl chr X:31,690,359...31,733,272

G

G protein-coupled receptor 157

decreases expression

EXP

Cocaine results in decreased expression of GPR157 mRNA

NCBI chr 5:165,833,651...165,849,376
Ensembl chr 5:165,833,673...165,851,280

G

G protein-coupled receptor 3

increases expression

EXP

Cocaine results in increased expression of GPR3 mRNA

NCBI chr 5:150,695,406...150,698,526
Ensembl chr 5:150,695,251...150,706,529

G

G-protein coupled receptor 88

affects expression
increases expression

EXP
ISO

Cocaine affects the expression of GPR88 mRNA
Cocaine deficiency results in increased expression of GPR88 mRNA

PMID:20187946 PMID:27126842

NCBI chr 2:206,876,373...206,885,034
Ensembl chr 2:206,868,585...206,884,945

G

G protein-coupled receptor associated sorting protein 1

affects expression

EXP

Cocaine affects the expression of GPRASP1 mRNA

NCBI chr X:103,556,493...103,564,275
Ensembl chr X:103,501,377...103,565,649

G

G-protein signaling modulator 1

affects expression

EXP

Cocaine affects the expression of GPSM1 protein

NCBI chr 3:29,538,929...29,565,921
Ensembl chr 3:29,526,802...29,565,920

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

ISO

PRKCD protein affects the reaction [Cocaine results in increased activity of GPT protein]; rottlerin inhibits the reaction [Cocaine results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases expression
affects response to substance
multiple interactions

ISO

Cocaine results in increased expression of GPX1 protein
GPX1 protein affects the susceptibility to Cocaine
GPX1 affects the reaction [Cocaine results in increased activity of SOD1 protein]; GPX1 affects the reaction [Cocaine results in increased activity of SOD2 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of PRKCD protein]; GPX1 protein affects the susceptibility to [Cocaine co-treated with prolinedithiocarbamate]; GPX1 protein inhibits the reaction [Cocaine affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in decreased expression of GNRH1 protein]; GPX1 protein inhibits the reaction [Cocaine results in increased activity of and affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; prolinedithiocarbamate promotes the reaction [Cocaine results in increased expression of GPX1 protein]

PMID:30027653 PMID:31059705

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

growth factor receptor bound protein 2

increases expression

EXP

Cocaine results in increased expression of GRB2 protein

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

glutamate ionotropic receptor AMPA type subunit 1

decreases response to substance
affects response to substance
increases response to substance
increases expression
decreases phosphorylation
multiple interactions
affects expression
increases phosphorylation
increases expression
decreases expression

ISO
EXP

GRIA1 results in decreased susceptibility to Cocaine
GRIA1 protein affects the susceptibility to Cocaine
GRIA1 protein results in increased susceptibility to Cocaine
GRIA1 protein mutant form results in decreased susceptibility to Cocaine; GRIA1 results in decreased susceptibility to Cocaine
Cocaine results in increased expression of GRIA1 mRNA; Cocaine results in increased expression of GRIA1 protein
Cocaine results in decreased phosphorylation of GRIA1 protein
6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIA1 protein]; Cocaine affects the phosphorylation of and affects the expression of GRIA1 protein; Cocaine results in increased phosphorylation of and results in increased transport of GRIA1 protein; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]; Ondansetron inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]; roscovitine inhibits the reaction [Cocaine results in decreased phosphorylation of GRIA1 protein]; U 0126 inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]
Cocaine affects the expression of GRIA1 mRNA; Cocaine affects the expression of GRIA1 protein
Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein; Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein]; resveratrol promotes the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]
Cocaine increases expression of Gria1 protein in the nucleus accumbens
Cocaine increases phosphorylation of Gria1 protein in prefrontal cortex, nucleus accumbens
Cocaine increases expression of Gria1 protein on nucleus accumbens cell surface
Cocaine increases phosphorylation of Gria1 protein in the shell of nucleus accumbens
Cocaine increases phosphorylation of Gria1 protein in the prefrontal cortex, premotor cortex
Cocaine decreases expression of Gria1 protein in the nucleus accumbens
Cocaine increases phosphorylation of Gria1 protein in the dorsal striatum
Cocaine increases phosphorylation of Gria1 protein in the hippocampal formation
Cocaine increases expression of Gria1 protein in the ventral tegmental area
Cocaine increases expression of Gria1 mRNA in the nucleus accumbens
Cocaine results in decreased expression of GRIA1 mRNA; Cocaine results in decreased expression of GRIA1 protein

CTD
RGD

PMID:9886066 PMID:11268215 PMID:11801363 PMID:12511956 PMID:12787079 More...

RGD:405820210, RGD:405820206, RGD:405818274, RGD:405650685, RGD:405650670, RGD:405650586, RGD:405650201, RGD:405650197, RGD:405649862, RGD:405649734, RGD:405649733, RGD:405096667

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309

G

glutamate ionotropic receptor AMPA type subunit 2

increases expression
increases abundance
decreases response to substance
multiple interactions
affects expression

ISO
EXP

Cocaine results in increased expression of GRIA2 protein
cocaine increases abundance of Gria2 Q subunit transcripts in nucleus accumbens shell
GRIA2 results in decreased susceptibility to Cocaine
Cocaine results in increased phosphorylation of and affects the localization of GRIA2 protein
Cocaine results in increased expression of GRIA2 mRNA
Cocaine affects the expression of GRIA2 mRNA; Cocaine affects the expression of GRIA2 protein

CTD
RGD

PMID:9886066 PMID:12511956 PMID:12787079 PMID:15140200 PMID:16363995 More...

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression
affects expression
increases expression

ISO
EXP

Cocaine results in decreased expression of GRIA3 mRNA
Cocaine affects the expression of GRIA3 protein
Cocaine results in increased expression of GRIA3 protein

PMID:9886066 PMID:12511956 PMID:15140200 PMID:16363995

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:125,103,782...125,369,679

G

glutamate ionotropic receptor AMPA type subunit 4

affects expression

ISO
EXP

Cocaine affects the expression of GRIA4 mRNA
Cocaine affects the expression of GRIA4 protein

PMID:9886066 PMID:15140200

NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:9,847,052...10,319,881

G

glutamate ionotropic receptor kainate type subunit 1

affects expression

EXP

Cocaine affects the expression of GRIK1 mRNA; Cocaine affects the expression of GRIK1 protein

PMID:12358776 PMID:15140200

NCBI chr11:40,655,974...41,056,966
Ensembl chr11:40,655,975...41,056,517

G

glutamate ionotropic receptor kainate type subunit 2

affects expression

EXP

Cocaine affects the expression of GRIK2 protein

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202

G

glutamate ionotropic receptor kainate type subunit 3

affects expression

EXP

Cocaine affects the expression of GRIK3 protein

NCBI chr 5:143,052,442...143,268,873
Ensembl chr 5:143,052,442...143,268,873

G

glutamate ionotropic receptor kainate type subunit 5

affects expression

EXP

Cocaine affects the expression of GRIK5 protein

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:89,733,741...89,794,962

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions
affects response to substance
increases expression
affects phosphorylation
affects expression
decreases expression

EXP
ISO

6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of GRIN1 protein]; Cocaine affects the phosphorylation of and affects the expression of GRIN1 protein; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]
GRIN1 protein affects the susceptibility to Cocaine
Cocaine results in increased expression of GRIN1 mRNA; Cocaine results in increased expression of GRIN1 protein
Cocaine affects the expression of GRIN1 mRNA; Cocaine affects the expression of GRIN1 protein
Cocaine results in decreased expression of GRIN1 mRNA

PMID:9886066 PMID:11032893 PMID:11801363 PMID:12457264 PMID:12670717 More...

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
increases expression
affects expression

ISO
EXP

HDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]
ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]
Cocaine results in increased expression of GRIN2A mRNA; Cocaine results in increased expression of GRIN2A protein
Cocaine affects the expression of GRIN2A mRNA; Cocaine affects the expression of GRIN2A protein

PMID:17898221 PMID:17988634 PMID:19105975 PMID:19306440 PMID:19474322 More...

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression
affects response to substance
multiple interactions
affects expression
decreases phosphorylation

EXP

Cocaine results in increased expression of GRIN2B protein
GRIN2B protein affects the susceptibility to Cocaine
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in decreased phosphorylation of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]
Cocaine affects the expression of GRIN2B mRNA; Cocaine affects the expression of GRIN2B protein

PMID:11032893 PMID:11801363 PMID:15140200 PMID:16794574 PMID:19105975 More...

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate ionotropic receptor NMDA type subunit 2C

affects expression

EXP

Cocaine affects the expression of GRIN2C mRNA

NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression
affects expression

EXP

Cocaine results in increased expression of GRIN2D mRNA
Cocaine affects the expression of GRIN2D mRNA

PMID:16076954 PMID:20187946

NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:105,444,813...105,481,236

G

glutamate ionotropic receptor NMDA type subunit 3A

affects expression

EXP

Cocaine affects the expression of GRIN3A protein

NCBI chr 5:68,802,333...69,001,880
Ensembl chr 5:68,804,970...69,001,558

G

glutamate ionotropic receptor NMDA type subunit 3B

affects expression

EXP

Cocaine affects the expression of GRIN3B protein

NCBI chr 7:10,381,495...10,387,817
Ensembl chr 7:10,381,496...10,387,817

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

EXP

Cocaine results in increased expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

glutamate receptor interacting protein 1

increases phosphorylation
multiple interactions

EXP
ISO

Cocaine results in increased phosphorylation of GRIP1 protein
[Cocaine co-treated with FOS protein mutant form] results in increased expression of GRIP1 mRNA

PMID:18355967 PMID:19439608

NCBI chr 7:56,820,501...57,477,877
Ensembl chr 7:56,820,704...57,468,417

G

glutamate receptor interacting protein 2

increases expression

EXP

Cocaine results in increased expression of GRIP2 mRNA

NCBI chr 4:125,828,609...125,913,693
Ensembl chr 4:125,828,609...125,913,750

G

G protein-coupled receptor kinase 2

affects expression
increases expression

EXP

Cocaine affects the expression of GRK2 mRNA
Cocaine results in increased expression of GRK2 mRNA

PMID:16076954 PMID:20187946

NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015

G

G protein-coupled receptor kinase 6

affects expression

EXP

Cocaine affects the expression of GRK6 mRNA

NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954

G

glutamate metabotropic receptor 1

affects response to substance

ISO

GRM1 affects the susceptibility to Cocaine

NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443

G

glutamate metabotropic receptor 2

increases activity
affects expression
decreases activity

EXP

Cocaine results in increased activity of GRM2 protein
Cocaine affects the expression of GRM2 protein
Cocaine results in decreased activity of GRM2 protein

PMID:18673447 PMID:19105975 PMID:20416862

NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:116,158,810...116,171,857

G

glutamate metabotropic receptor 3

increases activity
affects expression

EXP

Cocaine results in increased activity of GRM3 protein
Cocaine affects the expression of GRM3 protein

PMID:19105975 PMID:20416862

NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:25,319,942...25,564,764

G

glutamate metabotropic receptor 5

affects expression
increases expression
multiple interactions
affects localization
decreases response to substance

ISO
EXP

Cocaine affects the expression of GRM5 mRNA
Cocaine deficiency results in increased expression of GRM5 mRNA
Cocaine results in decreased expression of and results in decreased activity of GRM5 protein
Cocaine results in increased expression of GRM5 mRNA
Cocaine affects the expression of GRM5 protein
Cocaine affects the localization of GRM5 protein
GRM5 mutant form results in decreased susceptibility to Cocaine

PMID:9886066 PMID:15295029 PMID:17898221 PMID:19105975 PMID:19118598 More...

NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649

G

glutamate metabotropic receptor 7

increases expression

EXP

Cocaine results in increased expression of GRM7 mRNA

NCBI chr 4:145,286,714...146,169,099
Ensembl chr 4:145,286,924...146,169,201

G

gastrin releasing peptide receptor

affects expression

EXP

Cocaine affects the expression of GRPR mRNA

NCBI chr X:34,630,238...34,670,245
Ensembl chr X:34,630,229...34,670,245

G

glycogen synthase kinase 3 alpha

affects expression

EXP

Cocaine affects the expression of GSK3A mRNA

NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593

G

glycogen synthase kinase 3 beta

multiple interactions
increases activity

ISO

Cocaine results in decreased phosphorylation of and results in increased activity of GSK3B protein
Cocaine results in increased activity of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

gelsolin

decreases expression

ISO

Cocaine results in decreased expression of GSN mRNA

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850

G

glutathione-disulfide reductase

increases expression

EXP

Cocaine deficiency results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase omega 1

affects expression

ISO

Cocaine affects the expression of GSTO1 protein

NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167

G

glutathione S-transferase pi 1

affects response to substance

ISO

GSTP1 polymorphism affects the susceptibility to Cocaine

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

guanylate cyclase 1 soluble subunit alpha 1

increases expression

EXP

Cocaine results in increased expression of GUCY1A1 mRNA

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737

G

guanylate cyclase 1 soluble subunit beta 1

increases expression

EXP

Cocaine results in increased expression of GUCY1B1 mRNA

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

glycogenin 1

decreases expression

EXP

Cocaine results in decreased expression of GYG1 protein

NCBI chr 2:104,540,927...104,583,038
Ensembl chr 2:104,540,533...104,582,818

G

granzyme M

affects expression

EXP

Cocaine affects the expression of GZMM mRNA

NCBI chr 7:10,661,683...10,667,448
Ensembl chr 7:10,661,684...10,667,504

G

heart and neural crest derivatives expressed 1

affects expression

EXP

Cocaine affects the expression of HAND1 mRNA

NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684

G

hemoglobin, beta adult minor chain

increases expression

ISO

Cocaine results in increased expression of HBB-B2 protein modified form

NCBI chr 1:167,655,583...167,656,963

G

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

increases expression

ISO

Cocaine results in increased expression of HCN2 mRNA

NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:10,620,422...10,639,457

G

hypocretin neuropeptide precursor

affects expression
multiple interactions

EXP

Cocaine affects the expression of HCRT mRNA
Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA]

NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524

G

hypocretin receptor 2

affects expression

EXP

Cocaine affects the expression of HCRTR2 protein

NCBI chr 8:85,870,279...85,986,405
Ensembl chr 8:85,870,279...85,986,405

G

histone deacetylase 10

affects expression

EXP

Cocaine affects the expression of HDAC10 mRNA

NCBI chr 7:122,078,768...122,084,457
Ensembl chr 7:122,078,768...122,083,870

G

histone deacetylase 5

decreases activity
decreases response to substance
multiple interactions

ISO

Cocaine results in decreased activity of HDAC5 protein
HDAC5 results in decreased susceptibility to Cocaine
Cocaine results in increased phosphorylation of and results in increased localization of HDAC5 protein; HDAC5 affects the reaction [Cocaine affects the expression of ABCA5 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of ADAM1A mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of CUEDC1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of ERBIN mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of GNB4 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of KCNK4 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of KCNQ5 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of PRM1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of RAPGEF6 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of RGS20 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of SUV39H1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA]; HDAC5 affects the reaction [Cocaine affects the expression of WNT5A mRNA]

NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244

G

histone deacetylase 6

multiple interactions
decreases expression

EXP

(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in decreased expression of HDAC6 protein]

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

histidine decarboxylase

affects response to substance

ISO

HDC gene mutant form affects the susceptibility to Cocaine

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

decreases expression

EXP

Cocaine results in decreased expression of HECW2 mRNA

NCBI chr 9:62,853,904...63,247,472
Ensembl chr 9:62,859,645...63,074,758

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

increases expression

EXP

Cocaine results in increased expression of HERC1 mRNA

NCBI chr 8:75,796,347...75,965,347
Ensembl chr 8:75,796,357...75,965,347

G

Hedgehog-interacting protein

decreases expression

EXP

Cocaine results in decreased expression of HHIP mRNA

NCBI chr19:44,768,038...44,856,878
Ensembl chr19:44,767,536...44,862,795

G

hypoxia inducible factor 1 subunit alpha

decreases expression

ISO

Cocaine results in decreased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

HIG1 hypoxia inducible domain family, member 1A

affects expression
increases expression

EXP

Cocaine affects the expression of HIGD1A mRNA
Cocaine results in increased expression of HIGD1A protein

PMID:20187946 PMID:25100957

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

high mobility group AT-hook 1

affects expression

EXP

Cocaine affects the expression of HMGA1 mRNA

NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

EXP

Cocaine results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

homer scaffold protein 1

increases response to substance
increases expression
affects expression
multiple interactions
decreases response to substance

ISO
EXP

HOMER1 polymorphism results in increased susceptibility to Cocaine
Cocaine results in increased expression of HOMER1 protein
Cocaine affects the expression of HOMER1 mRNA; Cocaine affects the expression of HOMER1 protein
Cocaine affects the expression of and affects the localization of HOMER1 protein
HOMER1 protein results in decreased susceptibility to Cocaine
Cocaine results in increased expression of HOMER1 mRNA

PMID:15294147 PMID:16314758 PMID:18355967 PMID:19105975 PMID:19118598 More...

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

homer scaffold protein 2

multiple interactions
affects expression
decreases response to substance
decreases expression

ISO
EXP

Cocaine affects the reaction [HOMER2 mutant form results in decreased secretion of Excitatory Amino Acid Agents]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HOMER2 mRNA]
Cocaine affects the expression of HOMER2 mRNA
HOMER2 protein results in decreased susceptibility to Cocaine; HOMER2 results in decreased susceptibility to Cocaine

PMID:14684444 PMID:15294147 PMID:15545022 PMID:18355967 PMID:20187946

NCBI chr 1:144,968,207...145,069,022
Ensembl chr 1:144,976,436...145,068,997

G

homer scaffold protein 3

affects expression

EXP

Cocaine affects the expression of HOMER3 mRNA

NCBI chr16:19,166,141...19,176,701
Ensembl chr16:19,165,482...19,176,640

G

hippocalcin

increases expression

ISO

Cocaine deficiency results in increased expression of HPCA mRNA

NCBI chr 5:146,739,978...146,750,961
Ensembl chr 5:146,739,978...146,749,983

G

hippocalcin-like 1

decreases expression

ISO

Cocaine results in decreased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

hippocalcin-like 4

affects expression
increases expression

EXP

Cocaine affects the expression of HPCAL4 mRNA
Cocaine results in increased expression of HPCAL4 mRNA

PMID:17898221 PMID:20187946

NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:140,739,635...140,751,530

G

4-hydroxyphenylpyruvate dioxygenase

increases expression

EXP

Cocaine results in increased expression of HPD mRNA

NCBI chr12:39,042,246...39,053,596
Ensembl chr12:39,042,238...39,053,612

G

HPS1, biogenesis of lysosomal organelles complex 3 subunit 1

affects expression

EXP

Cocaine affects the expression of HPS1 mRNA

NCBI chr 1:251,500,427...251,526,529
Ensembl chr 1:251,500,427...251,526,739

G

heparan sulfate-glucosamine 3-sulfotransferase 2

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of HS3ST2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HS3ST2 mRNA]

NCBI chr 1:185,387,445...185,508,700
Ensembl chr 1:185,386,761...185,508,700

G

hydroxysteroid (17-beta) dehydrogenase 6

decreases expression

EXP

Cocaine results in decreased expression of HSD17B6 mRNA

NCBI chr 7:831,407...850,950
Ensembl chr 7:831,421...850,873

G

heat shock transcription factor 1

affects expression

EXP

Cocaine affects the expression of HSF1 mRNA

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein 90 alpha family class A member 1

increases expression

EXP

Cocaine deficiency results in increased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

decreases expression

EXP

Cocaine results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO

Cocaine results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

affects expression
increases expression

ISO
EXP

Cocaine affects the expression of HSPA1B mRNA
Cocaine results in increased expression of HSPA1B mRNA

PMID:15681117 PMID:27899881

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

ISO
EXP

Cocaine results in increased expression of HSPA5 mRNA
Cocaine results in increased expression of HSPA5 mRNA; Cocaine results in increased expression of HSPA5 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]

PMID:15009677 PMID:17303341 PMID:23644055

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 9

multiple interactions
increases expression

EXP

Anisomycin inhibits the reaction [Cocaine results in increased expression of HSPA9 protein]

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

heat shock protein family B (small) member 1

increases expression

EXP

Cocaine results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

affects expression

ISO

Cocaine affects the expression of HSPD1 protein

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

HIV-1 Tat specific factor 1

multiple interactions

EXP

[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Cocaine] results in decreased phosphorylation of HTATSF1 protein

NCBI chr X:139,972,742...139,986,923
Ensembl chr X:139,972,742...139,986,923

G

5-hydroxytryptamine receptor 1A

multiple interactions

EXP
ISO

Cocaine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]
Cocaine inhibits the reaction [Chronic constriction injury increases expression of Htr1a protein in dorsal raphe nucleus]

CTD
RGD

PMID:9723786 PMID:31045847

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 1B

increases response to substance
affects activity
multiple interactions

ISO
EXP

HTR1B mutant form results in increased susceptibility to Cocaine
Cocaine affects the activity of HTR1B protein
[3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine; [5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine; [CP 94253 binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine

PMID:9603521 PMID:9822762 PMID:17074068

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583

G

5-hydroxytryptamine receptor 1D

affects expression

EXP

Cocaine affects the expression of HTR1D mRNA

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

G

5-hydroxytryptamine receptor 2A

multiple interactions
affects activity
affects response to substance

ISO
EXP

[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; [Metergoline binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Methiothepin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; [Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; Cocaine inhibits the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]
Cocaine affects the activity of HTR2A protein
Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]
HTR2A protein affects the susceptibility to Cocaine

PMID:8392199 PMID:10764922 PMID:10773209 PMID:10773215 PMID:17259860

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 2C

multiple interactions
decreases expression
increases response to substance

ISO
EXP

[1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine; [6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine; HTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine]
Cocaine results in decreased expression of HTR2C mRNA
HTR2C mutant form results in increased susceptibility to Cocaine

PMID:10541732 PMID:12427861 PMID:16076954

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

5-hydroxytryptamine receptor 3A

decreases response to substance
multiple interactions

ISO
EXP

HTR3A mutant form results in decreased susceptibility to Cocaine
Cocaine inhibits the reaction [Serotonin results in increased activity of HTR3A protein]

PMID:17559417 PMID:32209479

NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884

G

5-hydroxytryptamine receptor 4

affects response to substance

EXP

HTR4 protein affects the susceptibility to Cocaine

NCBI chr18:58,036,277...58,221,327
Ensembl chr18:58,036,277...58,219,622

G

5-hydroxytryptamine receptor 6

multiple interactions

EXP

[Ro 4-6790 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine; [SB 271046 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine

NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147

G

hydrogen voltage-gated channel 1

decreases expression

EXP

Cocaine results in decreased expression of HVCN1 mRNA

NCBI chr12:40,001,205...40,030,671
Ensembl chr12:40,001,498...40,042,020

G

intercellular adhesion molecule 1

increases expression

EXP

Cocaine results in increased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interactor of little elongation complex ELL subunit 2

affects response to substance

ISO

ICE2 gene SNP affects the susceptibility to Cocaine

NCBI chr 8:78,921,962...78,965,983
Ensembl chr 8:78,924,421...78,966,200

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects expression

EXP

Cocaine affects the expression of IDH3A mRNA

NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:63,867,820...63,887,223

G

immediate early response 5

affects expression

EXP

Cocaine affects the expression of IER5 mRNA

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:69,820,451...69,822,543

G

interferon gamma

affects secretion
decreases expression
multiple interactions

ISO

Cocaine affects the secretion of IFNG protein
Cocaine results in decreased expression of IFNG mRNA; Cocaine results in decreased expression of IFNG protein
[Cocaine co-treated with Heroin] results in increased expression of IFNG protein

PMID:9787120 PMID:16766138 PMID:29673861

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon-related developmental regulator 1

affects expression

EXP

Cocaine affects the expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

intraflagellar transport 81

increases expression

EXP

Cocaine results in increased expression of IFT81 mRNA

NCBI chr12:39,618,559...39,697,971
Ensembl chr12:39,618,651...39,697,962

G

insulin-like growth factor 1 receptor

affects expression

EXP

Cocaine affects the expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor 2

decreases expression

EXP

Cocaine results in decreased expression of IGF2 mRNA

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

insulin-like growth factor binding protein 2

decreases expression

EXP

Cocaine results in decreased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

immunoglobulin superfamily, member 8

affects expression

EXP

Cocaine affects the expression of IGSF8 mRNA

NCBI chr13:87,282,015...87,314,018
Ensembl chr13:87,302,536...87,310,941

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects expression

EXP

Cocaine affects the expression of IKBKB mRNA

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions
increases expression
decreases secretion

ISO

[Cocaine co-treated with Heroin] results in increased expression of IL10 protein
Cocaine results in increased expression of IL10 protein
Cocaine results in decreased secretion of IL10 protein

PMID:9787120 PMID:16766138

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 16

decreases expression

EXP

Cocaine results in decreased expression of IL16 mRNA

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 18 binding protein

affects expression

EXP

Cocaine affects the expression of IL18BP mRNA

NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:165,784,069...165,786,955

G

interleukin 1 alpha

affects expression

EXP

Cocaine affects the expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression

ISO

Cocaine results in increased expression of IL1B mRNA

PMID:20948987 PMID:26558777

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO

[Cocaine co-treated with Heroin] results in increased expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 2 receptor subunit alpha

decreases secretion

ISO

Cocaine results in decreased secretion of IL2RA protein

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 4

multiple interactions

ISO

[Cocaine co-treated with Heroin] results in increased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 4 induced 1

decreases expression

EXP

Cocaine results in decreased expression of IL4I1 mRNA

NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:104,435,981...104,461,053

G

interleukin 6

decreases expression
increases expression
affects response to substance
multiple interactions

ISO
EXP

Cocaine results in decreased expression of IL6 protein
Cocaine results in increased expression of IL6 mRNA; Cocaine results in increased expression of IL6 protein
IL6 protein affects the susceptibility to Cocaine
[IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF mRNA; [IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]]; IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]; TNF protein affects the reaction [IL6 protein affects the susceptibility to Cocaine]

PMID:10864098 PMID:17068203 PMID:29673861

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

affects response to substance

ISO

IL6R protein affects the susceptibility to Cocaine

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

integrin-linked kinase

multiple interactions
increases expression

EXP

Cocaine affects the reaction [ILK protein affects the phosphorylation of AKT1 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased expression of DLG4 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased expression of SYN1 protein]; ILK mutant form inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]
Cocaine results in increased expression of ILK protein

PMID:18702665 PMID:19629758

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

internexin neuronal intermediate filament protein, alpha

multiple interactions
decreases expression

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of INA mRNA
Cocaine results in decreased expression of INA mRNA

NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:255,838,129...255,849,680

G

inhibin subunit alpha

decreases expression

ISO

Cocaine results in decreased expression of INHA mRNA

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009

G

insulin 2

decreases expression

ISO

Cocaine results in decreased expression of INS protein

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

interferon regulatory factor 9

decreases expression

ISO

Cocaine results in decreased expression of IRF9 mRNA

NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879

G

insulin receptor substrate 2

increases expression

EXP

Cocaine results in increased expression of IRS2 mRNA

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

insulin receptor substrate 3

increases expression

EXP

Cocaine results in increased expression of IRS3 mRNA

NCBI chr12:24,689,930...24,692,068
Ensembl chr12:24,689,909...24,692,068

G

integrin subunit beta 1

affects expression

ISO

Cocaine affects the expression of ITGB1 protein

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 1 binding protein 1

increases expression

ISO

Cocaine results in increased expression of ITGB1BP1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:46,549,999...46,564,398

G

integrin subunit beta 3

affects expression

ISO

Cocaine affects the expression of ITGB3 protein

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

integrin subunit beta 5

affects expression

EXP

Cocaine affects the expression of ITGB5 mRNA

NCBI chr11:80,333,588...80,449,373
Ensembl chr11:80,333,590...80,449,373

G

integrin subunit beta 6

increases expression

ISO

Cocaine results in increased expression of ITGB6 mRNA

NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333

G

integrin subunit beta 7

decreases expression

EXP

Cocaine results in decreased expression of ITGB7 mRNA

NCBI chr 7:135,225,962...135,243,522
Ensembl chr 7:135,226,555...135,243,597

G

inositol-trisphosphate 3-kinase B

increases expression

EXP

Cocaine results in increased expression of ITPKB mRNA

NCBI chr13:94,601,072...94,696,180
Ensembl chr13:94,601,167...94,696,179

G

inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions
increases expression

ISO
EXP

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of ITPR1 mRNA
Cocaine results in increased expression of ITPR1 protein

PMID:18355967 PMID:25100957

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

jagged canonical Notch ligand 2

affects expression

EXP

Cocaine affects the expression of JAG2 mRNA

NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:137,804,133...137,826,738

G

Janus kinase 2

increases phosphorylation
multiple interactions

ISO

Cocaine results in increased phosphorylation of JAK2 protein
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

janus kinase and microtubule interacting protein 2

increases expression

EXP

Cocaine results in increased expression of JAKMIP2 mRNA

NCBI chr18:35,783,472...35,998,849
Ensembl chr18:35,783,472...35,998,682

G

Jun dimerization protein 2

affects expression

EXP

Cocaine affects the expression of JDP2 mRNA

NCBI chr 6:110,988,927...111,033,392
Ensembl chr 6:110,992,806...111,033,392

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
affects expression

ISO
EXP

Cocaine promotes the reaction [JUN protein binds to FOSL2 protein]
Cocaine results in increased expression of JUN protein modified form
Cocaine affects the expression of JUN protein

PMID:15814102 PMID:16179556 PMID:17635674 PMID:18355967

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

affects expression
increases expression
multiple interactions

ISO
EXP

Cocaine affects the expression of JUNB protein
Cocaine results in increased expression of JUNB protein
Cocaine promotes the reaction [[SK&F 81297 co-treated with Quinpirole] results in increased expression of JUNB protein]; NPPC protein inhibits the reaction [Cocaine results in increased expression of JUNB mRNA]
Cocaine affects the expression of JUNB mRNA
SL 327 inhibits the reaction [Cocaine results in increased expression of JUNB protein]

PMID:1347779 PMID:11860464 PMID:12122080 PMID:15814102 PMID:16263220 More...

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of JUND protein
[JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine

PMID:15814102 PMID:20056891

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

junction plakoglobin

affects expression

EXP

Cocaine affects the expression of JUP mRNA

NCBI chr10:85,800,812...85,827,881
Ensembl chr10:85,800,814...85,827,429

G

kalirin, RhoGEF kinase

affects expression

EXP

Cocaine affects the expression of KALRN mRNA

NCBI chr11:79,703,345...80,309,210
Ensembl chr11:79,703,366...80,133,329

G

katanin regulatory subunit B1

affects expression

EXP

Cocaine affects the expression of KATNB1 mRNA

NCBI chr19:9,927,249...9,946,750
Ensembl chr19:9,927,249...9,946,738

G

potassium voltage-gated channel subfamily A member 2

multiple interactions

ISO

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNA2 mRNA]

NCBI chr 2:197,392,746...197,406,606
Ensembl chr 2:197,392,698...197,407,519

G

potassium voltage-gated channel subfamily A member 6

increases expression

EXP

Cocaine results in increased expression of KCNA6 mRNA

NCBI chr 4:161,229,103...161,262,352
Ensembl chr 4:161,191,961...161,263,240

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

decreases expression
affects expression

ISO
EXP

Cocaine results in decreased expression of KCNAB1 mRNA
Cocaine affects the expression of KCNAB1 mRNA

PMID:18000554 PMID:20187946

NCBI chr 2:151,446,975...151,913,636
Ensembl chr 2:151,446,947...151,913,636

G

potassium voltage-gated channel subfamily B member 1

multiple interactions
affects expression

ISO
EXP

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNB1 mRNA]
Cocaine affects the expression of KCNB1 mRNA

PMID:20187946 PMID:20947769

NCBI chr 3:176,239,285...176,332,408
Ensembl chr 3:176,242,589...176,332,408

G

potassium voltage-gated channel subfamily D member 1

multiple interactions

ISO

Cocaine affects the reaction [NTRK2 protein affects the expression of KCND1 mRNA]

NCBI chr X:17,333,612...17,349,255
Ensembl chr X:17,333,612...17,347,799

G

potassium voltage-gated channel subfamily D member 2

decreases expression

EXP

Cocaine results in decreased expression of KCND2 mRNA

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium voltage-gated channel subfamily D member 3

increases expression

EXP

Cocaine results in increased expression of KCND3 mRNA

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium voltage-gated channel interacting protein 3

affects expression

EXP

Cocaine affects the expression of KCNIP3 mRNA

NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216

G

potassium inwardly-rectifying channel, subfamily J, member 10

increases expression

EXP

Cocaine results in increased expression of KCNJ10 mRNA

NCBI chr13:87,334,510...87,367,747
Ensembl chr13:87,334,216...87,368,678

G

potassium inwardly-rectifying channel, subfamily J, member 11

decreases response to substance

ISO

KCNJ11 results in decreased susceptibility to Cocaine

NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169

G

potassium inwardly-rectifying channel, subfamily J, member 4

multiple interactions

ISO

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ4 mRNA]

NCBI chr 7:112,927,494...112,954,547
Ensembl chr 7:112,922,532...112,954,826

G

potassium inwardly-rectifying channel, subfamily J, member 6

affects expression
increases expression
decreases expression

EXP
ISO

Cocaine affects the expression of KCNJ6 mRNA
Cocaine results in increased expression of KCNJ6 mRNA
Cocaine results in decreased expression of KCNJ6 mRNA

PMID:12629581 PMID:17898221 PMID:20187946

NCBI chr11:47,531,312...47,778,348
Ensembl chr11:47,531,312...47,778,348

G

potassium inwardly-rectifying channel, subfamily J, member 8

multiple interactions

ISO

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ8 mRNA]

NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:177,239,908...177,246,531

G

potassium two pore domain channel subfamily K member 4

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of KCNK4 mRNA]

NCBI chr 1:213,547,577...213,558,706
Ensembl chr 1:213,547,577...213,555,861

G

potassium voltage-gated channel subfamily Q member 5

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of KCNQ5 mRNA]

NCBI chr 9:31,326,595...31,892,399
Ensembl chr 9:31,329,497...31,891,304

G

potassium sodium-activated channel subfamily T member 1

increases expression
multiple interactions

ISO

Cocaine results in increased expression of KCNT1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KCNT1 mRNA]

NCBI chr 3:29,081,071...29,136,902
Ensembl chr 3:29,081,321...29,134,768

G

lysine demethylase 3A

increases expression
multiple interactions

ISO

Cocaine results in increased expression of KDM3A mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of KDM3A mRNA]

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

KH RNA binding domain containing, signal transduction associated 1

affects expression

EXP

Cocaine affects the expression of KHDRBS1 mRNA

NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448

G

kinase D-interacting substrate 220

affects expression

EXP

Cocaine affects the expression of KIDINS220 mRNA

NCBI chr 6:47,346,790...47,435,599
Ensembl chr 6:47,346,832...47,431,865

G

kinesin family member 3a

increases expression

EXP

Cocaine results in increased expression of KIF3A mRNA; Cocaine results in increased expression of KIF3A protein

PMID:17898221 PMID:25100957

NCBI chr10:38,226,388...38,263,062
Ensembl chr10:38,226,741...38,260,516

G

kinesin family member C1

affects expression

EXP

Cocaine affects the expression of KIFC1 mRNA

NCBI chr20:5,000,929...5,018,967
Ensembl chr20:5,000,648...5,018,988

G

kirre like nephrin family adhesion molecule 3

increases expression

ISO

Cocaine results in increased expression of KIRREL3 mRNA

NCBI chr 8:41,123,692...41,663,528
Ensembl chr 8:41,123,878...41,664,147

G

Klotho

increases expression

ISO

Cocaine results in increased expression of KL mRNA

NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015

G

KLF transcription factor 4

affects expression

EXP

Cocaine affects the expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

KLF transcription factor 5

affects expression

EXP

Cocaine affects the expression of KLF5 mRNA

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

kelch domain containing 3

affects expression

EXP

Cocaine affects the expression of KLHDC3 mRNA

NCBI chr 9:21,799,870...21,806,337
Ensembl chr 9:21,799,729...21,806,334

G

kelch domain containing 7A

decreases expression

EXP

Cocaine results in decreased expression of KLHDC7A mRNA

NCBI chr 5:157,501,740...157,507,843
Ensembl chr 5:157,485,191...157,507,954

G

kelch-like family member 12

affects expression

EXP

Cocaine affects the expression of KLHL12 mRNA

NCBI chr13:48,451,920...48,485,638
Ensembl chr13:48,455,227...48,485,641

G

kelch-like family member 5

affects response to substance

ISO

KLHL5 gene SNP affects the susceptibility to Cocaine

NCBI chr14:43,497,915...43,565,833
Ensembl chr14:43,497,918...43,537,894

G

kallikrein 1-related peptidase B3

affects expression

EXP

Cocaine affects the expression of KLK1B3 mRNA

NCBI chr 1:103,845,647...103,849,854
Ensembl chr 1:103,845,603...103,849,855

G

lysine methyltransferase 2E

affects expression

EXP

Cocaine affects the expression of KMT2E mRNA

NCBI chr 4:12,550,570...12,655,329
Ensembl chr 4:12,550,570...12,619,721

G

karyopherin subunit beta 1

affects expression

EXP

Cocaine affects the expression of KPNB1 mRNA

NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,642,082...82,670,856

G

KRIT1, ankyrin repeat containing

increases expression

ISO

Cocaine results in increased expression of KRIT1 mRNA

NCBI chr 4:31,253,918...31,288,066
Ensembl chr 4:31,253,918...31,288,073

G

keratin 15

affects expression

EXP

Cocaine affects the expression of KRT15 mRNA

NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142

G

kyphoscoliosis peptidase

decreases expression

EXP

Cocaine results in decreased expression of KY mRNA

NCBI chr 8:111,965,862...112,005,206
Ensembl chr 8:111,965,862...112,005,206

G

laminin subunit beta 1

increases expression

ISO

Cocaine results in increased expression of LAMB1 mRNA

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760

G

lysosomal-associated membrane protein 2

increases expression

EXP

Cocaine results in increased expression of LAMP2 protein

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:121,922,187...122,087,675

G

LARGE xylosyl- and glucuronyltransferase 1

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of LARGE1 mRNA

NCBI chr19:11,609,004...12,057,174
Ensembl chr19:11,609,004...12,054,707

G

LIM domain binding 2

decreases expression

ISO

Cocaine results in decreased expression of LDB2 mRNA

NCBI chr14:70,489,243...70,810,573
Ensembl chr14:70,489,620...70,810,574

G

lactate dehydrogenase B

affects expression

EXP

Cocaine affects the expression of LDHB mRNA

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

lactate dehydrogenase D

affects expression

EXP

Cocaine affects the expression of LDHD mRNA

NCBI chr19:56,492,827...56,497,695
Ensembl chr19:56,482,924...56,509,197

G

LEM domain containing 3

increases expression

ISO

Cocaine results in increased expression of MAN1 mRNA

NCBI chr 7:58,300,556...58,389,485
Ensembl chr 7:58,316,851...58,384,707

G

leucine rich repeat containing G protein coupled receptor 5

decreases expression

EXP

Cocaine results in decreased expression of LGR5 mRNA

NCBI chr 7:52,973,151...53,107,964
Ensembl chr 7:52,974,332...53,108,163

G

luteinizing hormone subunit beta

increases secretion

ISO

Cocaine results in increased secretion of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIM zinc finger domain containing 2

affects expression

EXP

Cocaine affects the expression of LIMS2 mRNA

NCBI chr18:23,828,164...23,866,363
Ensembl chr18:23,837,686...23,867,086

G

lin-7 homolog B, crumbs cell polarity complex component

increases expression
multiple interactions

ISO

Cocaine results in increased expression of LIN7B mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LIN7B mRNA]

NCBI chr 1:104,983,368...104,986,795
Ensembl chr 1:104,982,771...104,986,078

G

lin-7 homolog C, crumbs cell polarity complex component

increases expression

ISO

Cocaine results in increased expression of LIN7C mRNA

NCBI chr 3:116,859,425...116,872,363
Ensembl chr 3:116,860,282...116,872,363

G

LIM domain 7

increases expression

EXP

Cocaine results in increased expression of LMO7 mRNA

NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551

G

LON peptidase N-terminal domain and ring finger 3

increases expression

EXP

Cocaine results in increased expression of LONRF3 mRNA

NCBI chr X:120,430,975...120,469,648
Ensembl chr X:120,430,996...120,464,572

G

lysyl oxidase

decreases expression

EXP

Cocaine results in decreased expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

lysophosphatidic acid receptor 1

decreases expression

ISO

Cocaine results in decreased expression of LPAR1 mRNA

NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:78,024,139...78,142,188

G

leucine rich repeat containing 27

decreases expression

EXP

Cocaine results in decreased expression of LRRC27 mRNA

NCBI chr 1:203,433,463...203,464,683
Ensembl chr 1:203,434,355...203,464,676

G

leucine rich repeat containing 7

affects response to substance

ISO

LRRC7 gene SNP affects the susceptibility to Cocaine

NCBI chr 2:249,792,441...250,294,267
Ensembl chr 2:249,805,448...250,293,718

G

LRR binding FLII interacting protein 1

increases expression

EXP

Cocaine results in increased expression of LRRFIP1 mRNA

NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:99,039,614...99,167,779

G

leucine rich repeat neuronal 1

affects expression

EXP

Cocaine affects the expression of LRRN1 mRNA

NCBI chr 4:142,032,805...142,072,320
Ensembl chr 4:142,032,041...142,074,760

G

limbic system-associated membrane protein

increases expression

EXP

Cocaine results in increased expression of LSAMP mRNA

NCBI chr11:72,053,285...74,223,019
Ensembl chr11:72,053,285...72,702,134

G

lymphocyte-specific protein 1

decreases expression

EXP

Cocaine results in decreased expression of LSP1 mRNA

NCBI chr 1:207,044,157...207,077,891
Ensembl chr 1:207,044,159...207,077,893

G

lymphotoxin beta receptor

affects expression

ISO

Cocaine affects the expression of LTBR mRNA

NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:159,795,115...159,807,296

G

lymphocyte antigen 6 family member H

increases expression

EXP

Cocaine results in increased expression of LY6H protein

NCBI chr 7:109,139,527...109,142,108
Ensembl chr 7:109,139,527...109,246,799

G

leucine zipper tumor suppressor family member 3

increases expression
multiple interactions

ISO

Cocaine results in increased expression of LZTS3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of LZTS3 mRNA]

NCBI chr 3:138,303,378...138,313,645
Ensembl chr 3:138,303,378...138,313,611

G

mab-21 like 2

decreases expression

EXP

Cocaine results in decreased expression of MAB21L2 mRNA

NCBI chr 2:174,244,538...174,247,620
Ensembl chr 2:174,238,828...174,252,064

G

MAF bZIP transcription factor F

increases expression

EXP

Cocaine results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAGE family member D1

affects expression

ISO

Cocaine affects the expression of MAGED1 mRNA

NCBI chr X:63,416,464...63,423,167
Ensembl chr X:63,416,466...63,423,112

G

mal, T-cell differentiation protein 2

increases expression

ISO

Cocaine results in increased expression of MAL2 mRNA

NCBI chr 7:87,790,239...87,823,219
Ensembl chr 7:87,790,239...87,850,403

G

mannosidase, endo-alpha

affects response to substance

ISO

MANEA gene SNP affects the susceptibility to Cocaine

NCBI chr 5:44,992,937...45,015,084
Ensembl chr 5:44,992,937...45,015,084

G

monoamine oxidase A

multiple interactions

ISO

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

multiple interactions

ISO

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 1A

increases expression

EXP

Cocaine results in increased expression of MAP1A mRNA

NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:128,716,940...128,740,159

G

microtubule-associated protein 1B

affects expression
decreases expression

EXP
ISO

Cocaine affects the expression of MAP1B mRNA
Cocaine results in decreased expression of MAP1B mRNA

PMID:12629581 PMID:20187946

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094

G

microtubule-associated protein 1 light chain 3 alpha

affects expression

EXP

Cocaine affects the expression of MAP1LC3A mRNA

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850

G

microtubule-associated protein 2

affects expression
decreases expression

EXP

Cocaine affects the expression of MAP2 mRNA
Cocaine results in decreased expression of MAP2 mRNA

PMID:16076954 PMID:20187946

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase kinase 1

decreases expression
multiple interactions
increases phosphorylation

ISO

Cocaine results in decreased expression of MAP2K1 mRNA
CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]

PMID:12629581 PMID:15665076

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

multiple interactions
increases phosphorylation

ISO

CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase kinase 4

increases expression

ISO

Cocaine results in increased expression of MAP2K4 mRNA

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

microtubule-associated protein 6

affects expression

EXP

Cocaine affects the expression of MAP6 mRNA

NCBI chr 1:162,980,339...163,046,548
Ensembl chr 1:162,980,181...163,046,548

G

mitogen activated protein kinase 1

multiple interactions
increases expression
increases phosphorylation
decreases activity
affects phosphorylation
increases activity

ISO
EXP

1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]
Cocaine results in increased expression of MAPK1 protein
Cocaine results in increased phosphorylation of MAPK1 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased expression of MAPK1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Cocaine results in decreased activity of MAPK1 protein
Cocaine affects the phosphorylation of MAPK1 protein
Cocaine results in increased activity of MAPK1 protein
[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein; [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of SYT7 protein; [Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of MAPK1 protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Cocaine results in increased phosphorylation of and results in increased localization of MAPK1 protein; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol promotes the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:15056714 PMID:15365088 PMID:15470197 PMID:15657599 PMID:15665076 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

decreases expression

ISO

Cocaine results in decreased expression of MAPK10 mRNA

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen-activated protein kinase 11

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of MAPK11 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of MAPK11 mRNA]

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen activated protein kinase 14

increases activity

ISO

Cocaine results in increased activity of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

increases expression
increases phosphorylation
affects phosphorylation
decreases activity
multiple interactions
decreases response to substance
increases activity

ISO
EXP

Cocaine results in increased expression of MAPK3 mRNA
Cocaine results in increased expression of MAPK3 protein
Cocaine results in increased phosphorylation of MAPK3 protein
Cocaine affects the phosphorylation of MAPK3 protein
Cocaine results in decreased activity of MAPK3 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased expression of MAPK3 protein]; Cocaine affects the phosphorylation of and affects the activity of MAPK3 protein; Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
MAPK3 protein results in decreased susceptibility to Cocaine
Cocaine results in increased activity of MAPK3 protein
[Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of MAPK3 protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK3 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Cocaine results in increased phosphorylation of and results in increased localization of MAPK3 protein; DRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GAL protein inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]

PMID:12629581 PMID:15056714 PMID:15365088 PMID:15470197 PMID:15657599 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 8 interacting protein 3

affects expression

EXP

Cocaine affects the expression of MAPK8IP3 mRNA

NCBI chr10:14,422,936...14,463,387
Ensembl chr10:14,422,936...14,462,812

G

membrane associated ring-CH-type finger 7

increases expression

ISO

Cocaine results in increased expression of MARCHF7 mRNA

NCBI chr 3:65,090,640...65,128,768
Ensembl chr 3:65,090,310...65,128,864

G

MARCKS-like 1

affects expression

EXP

Cocaine affects the expression of MARCKSL1 mRNA

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:147,134,514...147,138,417

G

microtubule affinity regulating kinase 1

affects expression

EXP

Cocaine affects the expression of MARK1 mRNA

NCBI chr13:98,981,727...99,086,998
Ensembl chr13:98,983,020...99,086,701

G

methionine adenosyltransferase 2A

affects expression

EXP

Cocaine affects the expression of MAT2A mRNA

NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645

G

methyl-CpG binding domain protein 1

increases expression

EXP

Cocaine results in increased expression of MBD1 protein

NCBI chr18:70,145,093...70,159,744
Ensembl chr18:70,145,114...70,159,703

G

myelin basic protein

decreases expression

ISO
EXP

Cocaine results in decreased expression of MBP mRNA; Cocaine results in decreased expression of MBP protein

PMID:15009677 PMID:19217266

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

malate dehydrogenase 1

decreases expression

ISO

Cocaine results in decreased expression of MDH1 mRNA

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

methyl CpG binding protein 2

multiple interactions
increases expression

ISO
EXP

MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein]; MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein]
Cocaine inhibits the reaction [MECP2 protein binds to BDNF promoter]
Cocaine results in increased expression of MECP2 protein
Cocaine affects the reaction [MECP2 protein affects the expression of BDNF protein]; Cocaine affects the reaction [MECP2 protein binds to and results in decreased activity of BDNF promoter]

PMID:16670375 PMID:20711185 PMID:20810894 PMID:24358339

NCBI chr X:156,932,481...156,995,981
Ensembl chr X:156,941,234...156,943,560

G

myocyte enhancer factor 2a

increases expression

EXP

Cocaine results in increased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162

G

myocyte enhancer factor 2D

decreases expression
multiple interactions

ISO
EXP

Cocaine results in decreased expression of MEF2D mRNA
Cocaine deficiency promotes the reaction [SMARCA4 protein binds to MEF2D promoter]

PMID:18000554 PMID:27422367

NCBI chr 2:175,904,332...175,933,451
Ensembl chr 2:175,903,959...175,930,760

G

multiple EGF-like domains 10

increases expression

EXP

Cocaine results in increased expression of MEGF10 mRNA

NCBI chr18:52,803,292...52,953,431
Ensembl chr18:52,847,781...52,950,675

G

methylphosphate capping enzyme

increases expression
multiple interactions

ISO

Cocaine results in increased expression of MEPCE mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of MEPCE mRNA]

NCBI chr12:24,548,596...24,553,315
Ensembl chr12:24,548,596...24,553,877

G

MET proto-oncogene, receptor tyrosine kinase

affects expression

ISO

Cocaine affects the expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

methyltransferase like 26

affects expression

EXP

Cocaine affects the expression of METTL26 mRNA

NCBI chr10:15,393,554...15,448,003
Ensembl chr10:15,398,654...15,441,062

G

mitochondrial fission factor

affects expression

EXP

Cocaine affects the expression of MFF mRNA

NCBI chr 9:91,455,931...91,484,171
Ensembl chr 9:91,455,871...91,484,171

G

monoglyceride lipase

affects expression

EXP

Cocaine affects the expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

MIA SH3 domain containing

increases expression

EXP

Cocaine results in increased expression of MIA mRNA

NCBI chr 1:91,601,326...91,603,019
Ensembl chr 1:91,601,327...91,603,019

G

microRNA 130a

increases expression
multiple interactions

ISO

Cocaine results in increased expression of MIR130A mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR130A mRNA]

NCBI chr 3:90,229,228...90,229,315

G

microRNA 132

multiple interactions
increases expression

ISO
EXP

MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein]

NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,522,033...60,522,133

G

microRNA 136

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR136 mRNA]

NCBI chr 6:134,331,335...134,331,416
Ensembl chr 6:134,331,335...134,331,416

G

microRNA 137

increases expression
multiple interactions

ISO

Cocaine results in increased expression of MIR137 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR137 mRNA]

NCBI chr 2:209,165,709...209,165,810
Ensembl chr 2:209,165,712...209,165,813

G

microRNA 138-1

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR138-1 mRNA]

NCBI chr 8:131,178,434...131,178,532
Ensembl chr 8:131,178,434...131,178,532

G

microRNA 148b

increases expression
multiple interactions

ISO

Cocaine results in increased expression of MIR148B mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR148B mRNA]

NCBI chr 7:136,299,870...136,299,966
Ensembl chr 7:136,299,870...136,299,966

G

microRNA 154

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR154 mRNA]

NCBI chr 6:134,574,352...134,574,435
Ensembl chr 6:134,574,352...134,574,435

G

microRNA 186

increases expression
multiple interactions

ISO

Cocaine results in increased expression of MIR186 mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR186 mRNA]

NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:249,241,650...249,241,735

G

microRNA 212

multiple interactions
increases expression

EXP
ISO

[[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein; [Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein; Cocaine affects the reaction [MIR212 protein affects the expression of BDNF protein]
Cocaine results in increased expression of MIR212 mRNA; Cocaine results in increased expression of MIR212 protein
MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein]

PMID:20613834 PMID:20711185

NCBI chr10:60,521,740...60,521,850
Ensembl chr10:60,521,740...60,521,850

G

microRNA 301b

increases expression
multiple interactions

ISO

Cocaine results in increased expression of MIR301B mRNA
AGO2 protein affects the reaction [Cocaine results in increased expression of MIR301B mRNA]

NCBI chr11:97,384,033...97,384,110
Ensembl chr11:97,384,033...97,384,110

G

microRNA 324

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR324 mRNA]

NCBI chr10:55,233,363...55,233,445
Ensembl chr10:55,233,361...55,233,449

G

microRNA 337

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR337 mRNA]

NCBI chr 6:134,321,142...134,321,238
Ensembl chr 6:134,321,141...134,321,237

G

microRNA 488

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]

NCBI chr13:73,216,541...73,216,619
Ensembl chr13:73,216,541...73,216,619

G

microRNA 500

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR500 mRNA]

NCBI chr X:17,930,647...17,930,726
Ensembl chr X:17,930,637...17,930,728

G

microRNA 544

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR544 mRNA]

NCBI chr 6:134,564,935...134,565,012
Ensembl chr 6:134,564,935...134,565,012

G

microRNA 665

multiple interactions
increases expression

ISO

AGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]

NCBI chr 6:134,321,679...134,321,772
Ensembl chr 6:134,321,679...134,321,772

G

membrane metallo-endopeptidase

multiple interactions

EXP

[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine]

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463

G

matrix metallopeptidase 13

decreases expression

EXP

Cocaine results in decreased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 14

affects expression

EXP

Cocaine affects the expression of MMP14 mRNA

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 23

affects expression
increases expression

EXP

Cocaine affects the expression of MMP23 mRNA
Cocaine results in increased expression of MMP23 mRNA

PMID:17898221 PMID:20187946

NCBI chr 5:171,521,905...171,525,007
Ensembl chr 5:171,520,494...171,524,695

G

matrix metallopeptidase 9

multiple interactions
increases expression

ISO
EXP

Cocaine results in decreased expression of and results in decreased activity of MMP9 protein
Cocaine results in increased expression of MMP9 mRNA

PMID:18000554 PMID:27899881

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myelin-associated oligodendrocyte basic protein

affects expression

EXP

Cocaine affects the expression of MOBP mRNA

NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:128,747,232...128,777,936

G

mitochondrial pyruvate carrier 2

increases expression

EXP

Cocaine results in increased expression of MPC2 protein

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:80,259,727...80,280,668

G

myeloperoxidase

increases activity

EXP

Cocaine results in increased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

major histocompatibility complex, class I-related

increases expression

EXP

Cocaine results in increased expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

muscle RAS oncogene homolog

affects expression

EXP

Cocaine affects the expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911

G

mannose receptor, C type 1

decreases expression

EXP

Cocaine results in decreased expression of MRC1 mRNA

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

mitochondrial rRNA methyltransferase 2

increases expression

ISO

Cocaine results in increased expression of MRM2 mRNA

NCBI chr12:19,423,448...19,428,662
Ensembl chr12:19,423,452...19,428,621

G

mitochondrial ribosomal protein L17

affects expression
increases expression

ISO
EXP

Cocaine affects the expression of MRPL17 mRNA
Cocaine results in increased expression of MRPL17 mRNA

PMID:17898221 PMID:18355967

NCBI chr 1:169,574,010...169,575,699
Ensembl chr 1:169,574,010...169,575,818

G

membrane spanning 4-domains A14

affects expression

EXP

Cocaine affects the expression of MS4A14 mRNA

NCBI chr 1:217,374,325...217,389,839
Ensembl chr 1:217,374,328...217,389,839

G

methionine sulfoxide reductase B2

affects expression

EXP

Cocaine affects the expression of MSRB2 mRNA

NCBI chr17:86,882,750...86,908,392
Ensembl chr17:86,882,394...86,908,391

G

mitochondrially encoded cytochrome c oxidase I

increases expression

EXP

Cocaine results in increased expression of COX1 protein

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

increases expression

EXP

Cocaine results in increased expression of ND4 protein

NCBI chr MT:10,160...11,537
Ensembl chr MT:10,145...11,522

G

mitochondrial fission process 1

affects expression

EXP

Cocaine affects the expression of MTFP1 mRNA

NCBI chr14:83,192,013...83,195,853
Ensembl chr14:83,192,021...83,195,927

G

myotrophin

affects expression

EXP

Cocaine affects the expression of MTPN mRNA

NCBI chr 4:65,126,390...65,153,803
Ensembl chr 4:65,115,980...65,153,924

G

microtubule associated scaffold protein 1

decreases expression

EXP

Cocaine results in decreased expression of MTUS1 mRNA

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474

G

muscle associated receptor tyrosine kinase

affects expression

EXP

Cocaine affects the expression of MUSK mRNA

NCBI chr 5:77,853,560...77,967,653
Ensembl chr 5:77,853,736...77,964,338

G

max dimerization protein 1

increases expression
increases expression

ISO

Cocaine results in increased expression of MXD1 mRNA
cocaine increases expression of Mxd1 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129

G

MYG1 exonuclease

affects expression

EXP

Cocaine affects the expression of MYG1 mRNA

NCBI chr 7:135,335,364...135,342,567
Ensembl chr 7:135,335,334...135,346,740

G

myosin heavy chain 6

decreases expression

EXP

Cocaine results in decreased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

increases expression

EXP

Cocaine results in increased expression of MYH7 mRNA

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin, heavy chain 9

affects expression

EXP

Cocaine affects the expression of MYH9 mRNA

NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:111,224,291...111,304,963

G

myosin VA

increases expression

EXP

Cocaine results in increased expression of MYO5A mRNA

NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:84,692,910...84,856,265

G

myomesin 1

affects expression

EXP

Cocaine affects the expression of MYOM1 mRNA

NCBI chr 9:118,362,547...118,485,954
Ensembl chr 9:118,362,621...118,485,952

G

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

increases expression

EXP

Cocaine results in increased expression of NAA15 mRNA

NCBI chr 2:137,608,883...137,671,618
Ensembl chr 2:137,608,797...137,671,619

G

nucleus accumbens associated 1

affects response to substance
increases expression

ISO
EXP

NACC1 protein affects the susceptibility to Cocaine
Cocaine results in increased expression of NACC1 mRNA; Cocaine results in increased expression of NACC1 protein alternative form

PMID:10934270 PMID:11906783 PMID:17945361

NCBI chr19:40,373,436...40,391,351
Ensembl chr19:40,373,449...40,391,347

G

NACC family member 2

affects expression

EXP

Cocaine affects the expression of NACC2 mRNA

NCBI chr 3:29,278,077...29,345,098
Ensembl chr 3:29,281,190...29,344,840

G

NALCN channel auxiliary factor 1

increases expression

EXP

Cocaine results in increased expression of NALF1 mRNA

NCBI chr16:86,415,540...86,938,150
Ensembl chr16:86,415,488...86,938,150

G

NSF attachment protein alpha

affects expression

EXP

Cocaine affects the expression of NAPA mRNA

NCBI chr 1:85,915,088...85,934,054
Ensembl chr 1:85,915,119...85,934,053

G

NSF attachment protein gamma

affects expression

EXP

Cocaine affects the expression of NAPG mRNA

NCBI chr18:58,710,702...58,729,450
Ensembl chr18:58,708,655...58,729,450

G

nuclear prelamin A recognition factor

affects expression

EXP

Cocaine affects the expression of NARF mRNA

NCBI chr10:107,017,344...107,035,777
Ensembl chr10:107,016,510...107,037,283

G

neurocalcin delta

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of NCALD mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NCALD mRNA]

NCBI chr 7:70,417,683...70,849,763
Ensembl chr 7:70,419,433...70,849,482

G

neurocan

affects expression

EXP

Cocaine affects the expression of NCAN mRNA

NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371

G

nuclear cap binding protein subunit 1

affects expression

EXP

Cocaine affects the expression of NCBP1 mRNA

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

neutrophil cytosolic factor 1

increases phosphorylation
multiple interactions
affects expression

EXP
ISO

Cocaine results in increased phosphorylation of NCF1 protein
Cocaine results in increased phosphorylation of and results in increased expression of NCF1 protein
Prazosin inhibits the reaction [Cocaine results in increased phosphorylation of NCF1 protein]
Cocaine affects the expression of NCF1 mRNA

PMID:15936005 PMID:18952886 PMID:20187946

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

neutrophil cytosolic factor 2

increases expression

ISO

Cocaine results in increased expression of NCF2 protein

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

neutrophil cytosolic factor 4

increases expression

ISO

Cocaine results in increased expression of NCF4 protein

NCBI chr 7:111,705,926...111,723,893
Ensembl chr 7:111,706,520...111,723,898

G

nuclear receptor coactivator 3

affects expression

EXP

Cocaine affects the expression of NCOA3 mRNA

NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631

G

neuronal calcium sensor 1

increases expression

ISO

Cocaine results in increased expression of NCS1 mRNA

NCBI chr 3:34,920,949...34,966,554
Ensembl chr 3:34,920,971...34,968,711

G

neuron-derived neurotrophic factor

decreases expression

EXP

Cocaine results in decreased expression of NDNF mRNA

NCBI chr 4:96,274,147...96,311,624
Ensembl chr 4:96,274,147...96,311,624

G

NDRG family member 2

decreases expression

ISO

Cocaine results in decreased expression of NDRG2 mRNA

NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125

G

NADH:ubiquinone oxidoreductase subunit A10

affects expression

ISO

Cocaine affects the expression of NDUFA10 protein

NCBI chr 9:100,454,498...100,490,023
Ensembl chr 9:100,437,379...100,489,264

G

NADH:ubiquinone oxidoreductase core subunit S2

affects expression

ISO

Cocaine affects the expression of NDUFS2 protein

NCBI chr13:86,186,867...86,203,914
Ensembl chr13:86,186,870...86,203,608

G

NADH:ubiquinone oxidoreductase core subunit V2

affects expression

EXP

Cocaine affects the expression of NDUFV2 mRNA

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

nebulin

decreases expression

EXP

Cocaine results in decreased expression of NEB mRNA

NCBI chr 3:57,022,822...57,220,752
Ensembl chr 3:57,022,822...57,220,709

G

N-terminal EF-hand calcium binding protein 2

affects expression
decreases expression

EXP

Cocaine affects the expression of NECAB2 mRNA
Cocaine results in decreased expression of NECAB2 protein

PMID:20187946 PMID:25100957

NCBI chr19:64,409,627...64,436,371
Ensembl chr19:64,409,751...64,436,369

G

NEDD4 like E3 ubiquitin protein ligase

increases expression

ISO

Cocaine results in increased expression of NEDD4L mRNA

NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824

G

neurofilament heavy chain

increases expression

EXP

Cocaine results in increased expression of NEFH protein

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

neurofilament light chain

affects expression
decreases expression

EXP
ISO

Cocaine affects the expression of NEFL mRNA
Cocaine results in decreased expression of NEFL mRNA

PMID:12629581 PMID:16076954 PMID:20187946

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

neurofilament medium chain

decreases expression

ISO

Cocaine results in decreased expression of NEFM mRNA

NCBI chr15:46,535,857...46,541,161
Ensembl chr15:46,535,517...46,541,163

G

neogenin 1

multiple interactions

ISO

[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein; Cocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of NEO1 protein]

NCBI chr 8:68,169,711...68,322,158
Ensembl chr 8:68,169,716...68,322,152

G

neuropilin and tolloid like 2

increases expression

ISO

Cocaine results in increased expression of NETO2 mRNA

NCBI chr19:37,517,518...37,588,961
Ensembl chr19:37,517,587...37,591,413

G

nexilin (F actin binding protein)

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of NEXN mRNA

NCBI chr 2:243,846,736...243,878,268
Ensembl chr 2:243,846,433...243,887,114

G

neurofibromin 1

increases expression

EXP

Cocaine results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

NFE2 like bZIP transcription factor 1

increases expression

ISO

Cocaine results in increased expression of NFE2L1 mRNA

NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Cocaine results in increased activity of and affects the localization of NFE2L2 protein; PRKCD protein affects the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; rottlerin promotes the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFE2 like bZIP transcription factor 3

increases expression

EXP

Cocaine results in increased expression of NFE2L3 mRNA

NCBI chr 4:81,837,404...81,865,258
Ensembl chr 4:81,837,404...81,865,532

G

nuclear factor kappa B subunit 1

affects expression

ISO

Cocaine affects the expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

affects expression

EXP

Cocaine affects the expression of NFKB2 mRNA

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

increases phosphorylation
multiple interactions
increases activity
affects expression

ISO
EXP

Cocaine results in increased phosphorylation of NFKBIA protein
SCH 23390 inhibits the reaction [Cocaine results in increased activity of NFKBIA protein]
Cocaine affects the expression of NFKBIA mRNA

PMID:15681117 PMID:19183502 PMID:20187946 PMID:20354174

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor zeta

decreases expression

EXP

Cocaine results in decreased expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767

G

NFU1 iron-sulfur cluster scaffold

increases expression

EXP

Cocaine results in increased expression of NFU1 mRNA

NCBI chr 4:121,016,316...121,036,925
Ensembl chr 4:121,016,393...121,037,493

G

nuclear transcription factor Y subunit beta

increases expression

ISO

Cocaine results in increased expression of NFYB mRNA

NCBI chr 7:22,852,543...22,868,116
Ensembl chr 7:22,852,546...22,882,294

G

nerve growth factor

decreases expression

ISO

Cocaine results in decreased expression of NGF protein

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nerve growth factor receptor

affects expression

ISO

Cocaine affects the expression of TNFRSF10B mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

ninein-like

decreases expression

EXP

Cocaine results in decreased expression of NLP mRNA

NCBI chr 3:160,208,757...160,275,077
Ensembl chr 3:160,196,883...160,275,108

G

nitrilase family, member 2

increases expression
multiple interactions

ISO

Cocaine results in increased expression of NIT2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NIT2 mRNA]

NCBI chr11:56,832,957...56,844,142
Ensembl chr11:56,832,558...56,844,141

G

NK2 homeobox 2

decreases expression

EXP

Cocaine results in decreased expression of NKX2-2 mRNA

NCBI chr 3:155,072,621...155,083,699
Ensembl chr 3:155,073,250...155,083,249

G

NME/NM23 nucleoside diphosphate kinase 2

affects expression

ISO

Cocaine affects the expression of NME2 protein

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

NME/NM23 family member 7

affects expression

EXP

Cocaine affects the expression of NME7 mRNA

NCBI chr13:79,190,462...79,319,890
Ensembl chr13:79,190,334...79,319,890

G

nitric oxide associated 1

affects expression

EXP

Cocaine affects the expression of NOA1 mRNA

NCBI chr14:31,189,570...31,205,600
Ensembl chr14:31,188,978...31,205,599

G

nucleolar protein 12

affects expression

EXP

Cocaine affects the expression of NOL12 mRNA

NCBI chr 7:112,373,749...112,379,362
Ensembl chr 7:112,373,845...112,380,357

G

non-POU domain containing, octamer-binding

affects expression

EXP

Cocaine affects the expression of NONO mRNA

NCBI chr X:70,594,116...70,611,976
Ensembl chr X:70,593,888...70,611,979

G

nitric oxide synthase 1

affects expression
affects response to substance
increases activity

EXP
ISO

Cocaine affects the expression of NOS1 protein
NOS1 protein affects the susceptibility to Cocaine
Cocaine results in increased activity of NOS1 protein

PMID:11032893 PMID:16698049 PMID:20477932

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 3

decreases expression
increases expression
decreases phosphorylation
multiple interactions

ISO
EXP

Cocaine results in decreased expression of NOS3 protein
Cocaine results in increased expression of NOS3 protein
Cocaine results in decreased phosphorylation of NOS3 protein
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of NOS3 mRNA]

PMID:17420087 PMID:18355967 PMID:18813882 PMID:19380615

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

neuronal PAS domain protein 2

decreases expression
multiple interactions
increases expression
affects response to substance

ISO
EXP

Cocaine results in decreased expression of NPAS2 mRNA
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Cocaine results in increased splicing of NPAS2 mRNA]
Cocaine results in increased expression of NPAS2 mRNA
NPAS2 affects the susceptibility to Cocaine
Cocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]; Cocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]; Cocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]

PMID:15994025 PMID:23776671 PMID:32312805

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

natriuretic peptide A

increases expression

EXP
ISO

Cocaine results in increased expression of NPPA mRNA
Cocaine results in increased expression of NPPA protein

PMID:9455993 PMID:11377647

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide C

multiple interactions

EXP

NPPC protein inhibits the reaction [Cocaine results in increased abundance of Dopamine]; NPPC protein inhibits the reaction [Cocaine results in increased expression of EGR1 mRNA]; NPPC protein inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; NPPC protein inhibits the reaction [Cocaine results in increased expression of JUNB mRNA]

NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186

G

NPR3-like, GATOR1 complex subunit

affects expression

EXP

Cocaine affects the expression of NPRL3 mRNA

NCBI chr10:15,859,739...15,900,261
Ensembl chr10:15,859,789...15,902,332

G

neuronal pentraxin 2

affects expression

EXP

Cocaine affects the expression of NPTX2 protein

NCBI chr12:15,151,136...15,162,045
Ensembl chr12:15,151,136...15,162,045

G

neuronal pentraxin receptor

decreases expression
multiple interactions

EXP
ISO

Cocaine results in decreased expression of NPTXR mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NPTXR mRNA]

PMID:16076954 PMID:18355967

NCBI chr 7:113,217,046...113,235,122
Ensembl chr 7:113,217,050...113,235,156

G

neuropeptide Y

affects expression
decreases expression

EXP

Cocaine affects the expression of NPY mRNA
Cocaine results in decreased expression of NPY mRNA

PMID:16076954 PMID:17851536 PMID:20187946

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

increases expression

EXP

Cocaine results in increased expression of NQO2 mRNA

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 1, group I, member 3

decreases expression

ISO

Cocaine results in decreased expression of NR1I3 mRNA

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 2, group F, member 2

increases expression

EXP

Cocaine results in increased expression of NR2F2 mRNA

NCBI chr 1:133,419,161...133,434,290
Ensembl chr 1:133,420,227...133,431,975

G

nuclear receptor subfamily 3, group C, member 1

increases response to substance
decreases expression

ISO
EXP

NR3C1 protein results in increased susceptibility to Cocaine
Cocaine results in decreased expression of NR3C1 mRNA
Cocaine results in decreased expression of NR3C1 protein

PMID:12805318 PMID:16188404 PMID:17689506 PMID:20948987

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 3, group C, member 2

increases expression

EXP

Cocaine deficiency results in increased expression of NR3C2 mRNA

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

nuclear receptor subfamily 4, group A, member 1

increases expression
affects expression

EXP

Cocaine results in increased expression of NR4A1 mRNA
Cocaine affects the expression of NR4A1 mRNA

PMID:12117546 PMID:12358776 PMID:17851536 PMID:20187946

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

ISO

Cocaine results in decreased expression of NR4A2 protein

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor subfamily 4, group A, member 3

increases expression

EXP

Cocaine results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

nuclear receptor interacting protein 3

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of NRIP3 mRNA

NCBI chr 1:173,224,532...173,249,829
Ensembl chr 1:173,224,532...173,251,769

G

neuritin 1

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of NRN1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NRN1 mRNA]

NCBI chr17:28,335,426...28,344,354
Ensembl chr17:28,334,616...28,344,354

G

neuropilin 1

increases expression

EXP

Cocaine results in increased expression of NRP1 mRNA

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

neuropilin 2

increases expression

EXP

Cocaine results in increased expression of NRP2 mRNA

NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871

G

neurturin

affects expression

EXP

Cocaine affects the expression of NRTN mRNA

NCBI chr 9:1,669,099...1,674,957
Ensembl chr 9:1,641,618...1,675,133

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

ISO

Cocaine results in decreased expression of NSF mRNA

NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621

G

netrin 1

decreases expression

EXP

Cocaine results in decreased expression of NTN1 mRNA

NCBI chr10:53,398,852...53,597,595
Ensembl chr10:53,398,852...53,584,060

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
decreases phosphorylation
affects expression
decreases expression

ISO
EXP

Cocaine affects the reaction [NTRK2 protein affects the expression of KCNA2 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCNB1 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCND1 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ4 mRNA]; Cocaine affects the reaction [NTRK2 protein affects the expression of KCNJ8 mRNA]; NTRK2 protein affects the reaction [Cocaine affects the expression of FOS protein]
Cocaine results in decreased phosphorylation of NTRK2 protein
Cocaine affects the expression of NTRK2 mRNA; Cocaine affects the expression of NTRK2 protein
Cocaine results in decreased expression of NTRK2 mRNA

PMID:12358776 PMID:15009677 PMID:16423334 PMID:16710320 PMID:20187946 More...

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

neurotensin

increases expression
multiple interactions

ISO
EXP

Cocaine results in increased expression of NTS mRNA
NTS protein inhibits the reaction [Cocaine results in decreased secretion of gamma-Aminobutyric Acid]
DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]

PMID:11120399 PMID:18252810 PMID:27899881

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

G

nuclear casein kinase and cyclin-dependent kinase substrate 1

decreases expression

ISO

Cocaine results in decreased expression of NUCKS1 mRNA

PMID:15009677 PMID:16710320

NCBI chr13:45,897,275...45,926,491
Ensembl chr13:45,897,248...45,923,101

G

nucleoporin 188

affects expression

EXP

Cocaine affects the expression of NUP188 mRNA

NCBI chr 3:33,957,778...34,014,122
Ensembl chr 3:33,957,791...34,014,122

G

nucleoporin 88

affects expression

EXP

Cocaine affects the expression of NUP88 mRNA

NCBI chr10:56,166,486...56,190,829
Ensembl chr10:56,166,486...56,191,383

G

nuclear protein 1, transcriptional regulator

affects expression

EXP

Cocaine affects the expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

affects expression

EXP

Cocaine affects the expression of OBSCN mRNA

NCBI chr10:44,273,686...44,419,275
Ensembl chr10:44,288,866...44,419,297

G

obscurin like cytoskeletal adaptor 1

increases expression

EXP

Cocaine results in increased expression of OBSL1 mRNA

NCBI chr 9:84,416,447...84,442,415
Ensembl chr 9:84,416,240...84,442,415

G

OCIA domain containing 2

increases expression

EXP

Cocaine results in increased expression of OCIAD2 protein

NCBI chr14:35,225,291...35,243,306
Ensembl chr14:35,225,255...35,243,311

G

Obg-like ATPase 1

affects expression

EXP

Cocaine affects the expression of OLA1 mRNA

NCBI chr 3:78,374,440...78,493,401
Ensembl chr 3:78,374,441...78,492,012

G

olfactomedin 1

affects expression

EXP

Cocaine affects the expression of OLFM1 mRNA

NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:31,918,573...31,956,260

G

oligophrenin 1

increases expression

ISO

Cocaine results in increased expression of OPHN1 mRNA

NCBI chr X:67,639,956...68,018,217
Ensembl chr X:67,643,252...68,016,831

G

opioid receptor, delta 1

affects localization
multiple interactions

EXP

Cocaine affects the localization of OPRD1 protein
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]

PMID:18417105 PMID:19279569

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

multiple interactions
increases expression

EXP
ISO

[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; Cocaine affects the reaction [enadoline binds to OPRK1 protein]
Cocaine deficiency results in increased expression of OPRK1 mRNA
Cocaine results in increased expression of OPRK1 protein

PMID:11113311 PMID:17621646 PMID:27126842

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

multiple interactions
increases expression
decreases expression
affects expression
decreases response to substance
affects response to substance
increases response to substance
increases activity

ISO
EXP

Cocaine affects the reaction [carfentanil binds to OPRM1 protein]
Cocaine deficiency results in increased expression of OPRM1 mRNA
Cocaine results in decreased expression of OPRM1 mRNA
[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]; [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine; CTAP octapeptide inhibits the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine]
Cocaine affects the expression of OPRM1 mRNA; Cocaine affects the expression of OPRM1 protein
PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein]
OPRM1 gene mutant form results in decreased susceptibility to Cocaine; OPRM1 mutant form results in decreased susceptibility to Cocaine
OPRM1 protein affects the susceptibility to Cocaine
OPRM1 gene SNP results in increased susceptibility to Cocaine

PMID:10803207 PMID:10891866 PMID:12128154 PMID:12815747 PMID:15664692 More...

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

oxysterol binding protein-like 1A

decreases expression

ISO

Cocaine results in decreased expression of OSBPL1A mRNA

NCBI chr18:4,178,734...4,383,511
Ensembl chr18:4,179,631...4,369,421

G

otoferlin

decreases expression

EXP

Cocaine results in decreased expression of OTOF mRNA

NCBI chr 6:31,647,869...31,744,476
Ensembl chr 6:31,647,914...31,744,476

G

oxytocin receptor

affects expression
multiple interactions

EXP

Cocaine affects the expression of OXTR protein
Cocaine affects the reaction [vasotocin, (beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-O-methyl-Tyr(2)-Thr(4)-Orn(8)-Tyr(9)-NH2 binds to OXTR protein]

NCBI chr 4:147,154,374...147,171,723
Ensembl chr 4:147,154,374...147,170,750

G

proliferation-associated 2G4

increases expression

EXP

Cocaine results in increased expression of PA2G4 mRNA

NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:1,569,327...1,576,802

G

poly(A) binding protein, cytoplasmic 1

affects expression

EXP

Cocaine affects the expression of PABPC1 mRNA

NCBI chr 7:69,662,513...69,674,806
Ensembl chr 7:69,663,068...69,675,050

G

platelet-activating factor acetylhydrolase 2

decreases expression

EXP

Cocaine results in decreased expression of PAFAH2 mRNA

NCBI chr 5:151,890,751...151,919,896
Ensembl chr 5:151,896,832...151,919,894

G

p21 (RAC1) activated kinase 6

decreases expression

ISO

Cocaine results in decreased expression of PAK6 mRNA

NCBI chr 3:126,092,576...126,128,320
Ensembl chr 3:126,093,013...126,128,318

G

protein associated with LIN7 1, MAGUK p55 family member

increases expression

EXP

Cocaine results in increased expression of PALS1 mRNA

NCBI chr 6:103,327,965...103,384,543
Ensembl chr 6:103,281,154...103,387,209

G

progestin and adipoQ receptor family member 4

affects expression

EXP

Cocaine affects the expression of PAQR4 mRNA

NCBI chr10:13,263,559...13,267,237
Ensembl chr10:13,263,559...13,267,173

G

poly (ADP-ribose) polymerase 1

increases cleavage
affects expression

EXP
ISO

Cocaine results in increased cleavage of PARP1 protein
Cocaine affects the expression of PARP1 mRNA

PMID:15681117 PMID:17084983

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

parvin, alpha

affects expression

EXP

Cocaine affects the expression of PARVA mRNA

NCBI chr 1:175,981,725...176,139,523
Ensembl chr 1:175,981,432...176,139,526

G

paired box 8

increases expression

ISO

Cocaine results in increased expression of PAX8 mRNA

NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:27,584,002...27,640,631

G

PBX homeobox 1

decreases expression
increases expression

EXP

Cocaine results in decreased expression of PBX1 mRNA
Cocaine results in increased expression of PBX1 mRNA

NCBI chr13:82,811,664...83,121,447
Ensembl chr13:82,812,131...83,121,066

G

PBX homeobox 2

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PBX2 mRNA

NCBI chr20:4,156,107...4,161,503
Ensembl chr20:4,156,107...4,161,827

G

PBX homeobox 3

increases expression
multiple interactions

ISO

Cocaine results in increased expression of PBX3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PBX3 mRNA]

NCBI chr 3:37,886,241...38,079,956
Ensembl chr 3:37,886,687...38,079,895

G

protocadherin 7

increases expression

EXP

Cocaine results in increased expression of PCDH7 mRNA

NCBI chr14:56,684,817...57,114,976
Ensembl chr14:56,687,725...57,112,665

G

protocadherin 8

increases expression

ISO

Cocaine results in increased expression of PCDH8 mRNA; Cocaine results in increased expression of PCDH8 protein

NCBI chr15:61,607,521...61,612,090
Ensembl chr15:61,607,521...61,612,097

G

protocadherin alpha 2

increases expression

ISO

Cocaine results in increased expression of PCDHA2 mRNA

G

protocadherin gamma subfamily A, 1

increases expression

ISO

Cocaine results in increased expression of PCDHGA1 mRNA

NCBI chr18:29,738,639...29,919,095

G

protocadherin gamma subfamily C, 3

affects expression

EXP

Cocaine affects the expression of PCDHGC3 mRNA

NCBI chr18:29,884,245...29,919,095

G

Purkinje cell protein 4

decreases expression

EXP

Cocaine results in decreased expression of PCP4 mRNA

NCBI chr11:49,229,185...49,331,186
Ensembl chr11:49,270,186...49,331,186

G

proprotein convertase subtilisin/kexin type 1

increases expression

EXP

Cocaine results in increased expression of PCSK1 mRNA

NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:6,129,592...6,176,974

G

proprotein convertase subtilisin/kexin type 1 inhibitor

decreases expression

ISO

Cocaine results in decreased expression of PCSK1N mRNA

NCBI chr X:17,251,963...17,255,405
Ensembl chr X:17,251,965...17,257,360

G

proprotein convertase subtilisin/kexin type 2

decreases expression

ISO

Cocaine results in decreased expression of PCSK2 mRNA

NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849

G

programmed cell death 11

increases expression

EXP

Cocaine results in increased expression of PDCD11 mRNA

NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336

G

programmed cell death 5

affects expression

ISO

Cocaine affects the expression of PDCD5 mRNA

NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:97,442,755...97,449,844

G

programmed cell death 6

affects expression

ISO

Cocaine affects the expression of PDCD6 mRNA

NCBI chr 1:30,795,105...30,810,771
Ensembl chr 1:30,795,040...30,810,773

G

programmed cell death 7

increases expression

ISO

Cocaine results in increased expression of PDCD7 mRNA

NCBI chr 8:74,757,768...74,772,495
Ensembl chr 8:74,757,768...74,781,634

G

phosphodiesterase 10A

increases expression

ISO

Cocaine deficiency results in increased expression of PDE10A mRNA

NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051

G

phosphodiesterase 4D interacting protein

decreases expression

ISO

Cocaine results in decreased expression of PDE4DIP mRNA

NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869

G

protein disulfide isomerase family A, member 3

affects expression
multiple interactions

EXP
ISO

Cocaine affects the expression of PDIA3 mRNA
Cocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form]

PMID:20187946 PMID:24096156

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 4

affects expression

EXP

Cocaine affects the expression of PDIA4 mRNA

NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

increases expression

EXP

Cocaine results in increased expression of PDP1 mRNA

NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960

G

3-phosphoinositide dependent protein kinase-1

affects expression

EXP

Cocaine affects the expression of PDPK1 mRNA

NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181

G

prodynorphin

increases expression
affects expression
increases response to substance
multiple interactions
affects response to substance
decreases response to substance

ISO
EXP

Cocaine results in increased expression of PDYN mRNA; Cocaine results in increased expression of PDYN protein
Cocaine deficiency results in increased expression of PDYN mRNA; Cocaine results in increased expression of PDYN mRNA; Cocaine results in increased expression of PDYN protein
Cocaine affects the expression of PDYN mRNA; Cocaine affects the expression of PDYN protein
PDYN gene mutant form results in increased susceptibility to Cocaine
[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein; Cocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of PDYN protein]; DRD3 protein inhibits the reaction [Cocaine results in increased expression of PDYN protein]; PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]; PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein]; PDYN protein promotes the reaction [Cocaine results in increased abundance of Corticosterone]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased expression of PDYN protein]
PDYN promoter polymorphism results in increased susceptibility to Cocaine
PDYN gene SNP affects the susceptibility to Cocaine
PDYN promoter polymorphism results in decreased susceptibility to Cocaine

PMID:7905595 PMID:10943692 PMID:10971637 PMID:11427339 PMID:11739600 More...

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

PDZ domain containing 1

decreases expression

EXP

Cocaine results in decreased expression of PDZK1 mRNA

NCBI chr 2:187,064,995...187,096,348
Ensembl chr 2:187,065,013...187,096,806

G

phosphatidylethanolamine binding protein 1

affects expression

ISO
EXP

Cocaine affects the expression of PEBP1 protein
Cocaine affects the expression of PEBP1 mRNA

PMID:19393250 PMID:20187946

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

proenkephalin

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of PENK mRNA
Cocaine results in increased expression of PENK mRNA
Cocaine deficiency results in increased expression of PENK mRNA; Cocaine results in increased expression of PENK mRNA

PMID:7905595 PMID:8028798 PMID:12523490 PMID:12670717 PMID:15042275 More...

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705

G

period circadian regulator 1

affects expression
multiple interactions
increases expression

EXP
ISO

Cocaine affects the expression of PER1 mRNA
[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PER1 mRNA; Cocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]
Cocaine results in increased expression of PER1 mRNA; Cocaine results in increased expression of PER1 protein

PMID:15994025 PMID:18355967 PMID:20187946 PMID:23776671 PMID:27899881

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

affects expression
multiple interactions
increases expression

ISO

Cocaine affects the expression of PER2 mRNA
Cocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]
Cocaine results in increased expression of PER2 mRNA; Cocaine results in increased expression of PER2 protein

PMID:15994025 PMID:20056891 PMID:23776671

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

period circadian regulator 3

increases expression
multiple interactions

ISO

Cocaine results in increased expression of PER3 mRNA; Cocaine results in increased expression of PER3 protein
Cocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]

PMID:15994025 PMID:23776671

NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:166,743,050...166,777,999

G

peroxisomal biogenesis factor 11 beta

affects expression

EXP

Cocaine affects the expression of PEX11B mRNA

NCBI chr 2:186,858,222...186,869,814
Ensembl chr 2:186,860,912...186,869,800

G

peroxisomal biogenesis factor 16

increases expression

EXP

Cocaine results in increased expression of PEX16 mRNA

NCBI chr 3:98,800,357...98,808,091
Ensembl chr 3:98,798,654...98,808,630

G

peroxisomal biogenesis factor 2

affects expression

EXP

Cocaine affects the expression of PEX2 mRNA

NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:97,948,443...97,981,092

G

peroxisomal biogenesis factor 5-like

increases expression

EXP

Cocaine results in increased expression of PEX5L mRNA

NCBI chr 2:117,623,199...117,836,772
Ensembl chr 2:117,623,199...117,836,685

G

platelet factor 4

increases expression

ISO

Cocaine results in increased expression of PF4 protein

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392

G

phosphofructokinase, liver type

affects expression

EXP

Cocaine affects the expression of PFKL mRNA

NCBI chr20:10,663,907...10,685,967
Ensembl chr20:10,663,955...10,685,966

G

profilin 1

increases expression

ISO

Cocaine results in increased expression of PFN1 mRNA

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

placental growth factor

affects expression

EXP

Cocaine affects the expression of PGF mRNA

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747

G

progesterone receptor

increases expression
affects expression

EXP

Cocaine results in increased expression of PGR protein
Cocaine affects the expression of PGR mRNA

PMID:17109827 PMID:20187946

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphorylase kinase catalytic subunit gamma 2

affects expression

EXP

Cocaine affects the expression of PHKG2 mRNA

NCBI chr 1:191,614,738...191,627,615
Ensembl chr 1:191,614,865...191,627,616

G

pleckstrin homology-like domain, family A, member 3

affects expression

EXP

Cocaine affects the expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

PH domain and leucine rich repeat protein phosphatase 2

affects expression

EXP

Cocaine affects the expression of PHLPP2 mRNA

NCBI chr19:54,744,581...54,811,258
Ensembl chr19:54,744,581...54,812,259

G

PILR alpha associated neural protein

affects expression

EXP

Cocaine affects the expression of PIANP mRNA

NCBI chr 4:159,482,678...159,491,085
Ensembl chr 4:159,482,648...159,491,083

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases expression

ISO

Cocaine results in decreased expression of PIM1 mRNA

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764

G

Pim-3 proto-oncogene, serine/threonine kinase

affects expression

EXP

Cocaine affects the expression of PIM3 mRNA

NCBI chr 7:121,822,076...121,836,257
Ensembl chr 7:121,832,742...121,836,259

G

PIN2/TERF1 interacting, telomerase inhibitor 1

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA

NCBI chr15:42,273,805...42,333,047
Ensembl chr15:42,273,799...42,333,047

G

pipecolic acid and sarcosine oxidase

decreases expression

EXP

Cocaine results in decreased expression of PIPOX mRNA

NCBI chr10:63,267,946...63,281,556
Ensembl chr10:63,267,972...63,282,273

G

phosphatidylinositol transfer protein, alpha

affects expression

EXP

Cocaine affects the expression of PITPNA mRNA

NCBI chr10:60,929,050...60,969,614
Ensembl chr10:60,929,007...60,971,830

G

paired-like homeodomain 3

decreases expression

ISO

Cocaine results in decreased expression of PITX3 protein

NCBI chr 1:254,942,550...254,955,325
Ensembl chr 1:254,942,608...254,955,336

G

praja ring finger ubiquitin ligase 2

decreases expression

EXP

Cocaine results in decreased expression of PJA2 mRNA

NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703

G

polycystin 2 like 2, transient receptor potential cation channel

increases expression

EXP

Cocaine results in increased expression of PKD2L2 mRNA

NCBI chr18:26,281,719...26,316,583
Ensembl chr18:26,281,941...26,316,583

G

pyruvate kinase M1/2

affects expression

EXP

Cocaine affects the expression of PKM mRNA

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

PBX/knotted 1 homeobox 2

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PKNOX2 mRNA

NCBI chr 8:44,789,464...45,051,933
Ensembl chr 8:44,789,467...44,979,754

G

plakophilin 2

increases expression

EXP

Cocaine results in increased expression of PKP2 mRNA

NCBI chr11:98,165,974...98,231,916
Ensembl chr11:98,165,974...98,231,916

G

phospholipase A2 group VI

affects expression

EXP

Cocaine affects the expression of PLA2G6 mRNA

NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609

G

phospholipase A2 receptor 1

increases expression

EXP

Cocaine results in increased expression of PLA2R1 mRNA

NCBI chr 3:65,292,629...65,422,462
Ensembl chr 3:65,292,629...65,422,335

G

PLAG1 like zinc finger 1

increases expression

EXP

Cocaine results in increased expression of PLAGL1 mRNA

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:9,330,204...9,337,394

G

phospholipase C beta 1

increases expression

ISO

Cocaine results in increased expression of PLCB1 mRNA

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

phospholipase C, gamma 1

affects phosphorylation

EXP

Cocaine affects the phosphorylation of PLCG1 protein

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

phospholipase D2

decreases expression

EXP

Cocaine results in decreased expression of PLD2 mRNA

NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435

G

plectin

affects expression

EXP

Cocaine affects the expression of PLEC mRNA

NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089

G

pleckstrin

decreases expression

EXP

Cocaine results in decreased expression of PLEK mRNA

NCBI chr14:95,598,650...95,631,326
Ensembl chr14:95,598,654...95,655,721

G

pleckstrin homology domain containing A5

affects expression
increases expression

EXP

Cocaine affects the expression of PLEKHA5 mRNA
Cocaine results in increased expression of PLEKHA5 mRNA

PMID:17898221 PMID:20187946

NCBI chr 4:175,065,011...175,234,672
Ensembl chr 4:175,065,183...175,234,672

G

pleckstrin homology domain containing A8

increases expression

EXP

Cocaine results in increased expression of PLEKHA8 mRNA

NCBI chr 4:85,053,765...85,104,376
Ensembl chr 4:85,053,854...85,104,376

G

proteolipid protein 1

affects expression
decreases expression

ISO

Cocaine affects the expression of PLP1 mRNA
Cocaine results in decreased expression of PLP1 mRNA

PMID:12629581 PMID:15009677 PMID:18357522

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:104,975,780...104,993,314

G

phospholipid phosphatase 1

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PLPP1 mRNA

NCBI chr 2:46,172,202...46,233,632
Ensembl chr 2:46,172,197...46,234,676

G

phospholipid phosphatase 2

decreases expression
affects expression

ISO
EXP

Cocaine results in decreased expression of PLPP2 mRNA
Cocaine affects the expression of PLPP2 mRNA

PMID:12629581 PMID:20187946

NCBI chr 7:10,826,534...10,834,628
Ensembl chr 7:10,826,549...10,834,627

G

phospholipid phosphatase 3

increases expression

EXP

Cocaine results in increased expression of PLPP3 mRNA

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667

G

phospholipid phosphatase related 2

affects expression

EXP

Cocaine affects the expression of PLPPR2 mRNA

NCBI chr 8:28,742,787...28,755,555
Ensembl chr 8:28,745,639...28,755,555

G

plexin B2

affects expression

EXP

Cocaine affects the expression of PLXNB2 mRNA

NCBI chr 7:122,111,917...122,138,201
Ensembl chr 7:122,111,917...122,127,746

G

prostate transmembrane protein, androgen induced 1

increases expression

ISO

Cocaine results in increased expression of PMEPA1 mRNA

PMID:15009677 PMID:16710320

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649

G

PNMA family member 8B

increases expression

EXP

Cocaine results in increased expression of PNMA8B mRNA

NCBI chr 1:86,749,840...86,754,605
Ensembl chr 1:86,748,610...86,767,756

G

RNA polymerase II, I and III subunit F

affects expression

EXP

Cocaine affects the expression of POLR2F mRNA

NCBI chr 7:112,592,977...112,604,681
Ensembl chr 7:112,593,027...112,604,666

G

proopiomelanocortin

increases secretion
increases expression
increases response to substance
multiple interactions

ISO
EXP

Cocaine results in increased secretion of POMC protein
Cocaine results in increased expression of POMC protein; Cocaine results in increased expression of POMC protein alternative form
POMC results in increased susceptibility to Cocaine
[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]; eticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein]

PMID:8301594 PMID:9610951 PMID:11750770 PMID:17001283 PMID:18176854 More...

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)

affects expression

EXP

Cocaine affects the expression of POMGNT1 mRNA

NCBI chr 5:134,870,971...134,880,864
Ensembl chr 5:134,870,975...134,880,863

G

POU class 3 homeobox 1

increases expression

EXP

Cocaine results in increased expression of POU3F1 mRNA

NCBI chr 5:142,195,090...142,198,070
Ensembl chr 5:142,194,066...142,202,704

G

POU class 3 homeobox 3

affects expression

EXP

Cocaine affects the expression of POU3F3 mRNA

NCBI chr 9:52,438,026...52,441,152
Ensembl chr 9:52,435,625...52,454,705

G

pro-platelet basic protein

increases expression

ISO

Cocaine results in increased expression of PPBP protein

NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299

G

PTPRF interacting protein alpha 3

increases expression

ISO

Cocaine results in increased expression of PPFIA3 protein

NCBI chr 1:104,953,598...104,982,373
Ensembl chr 1:104,953,598...104,982,278

G

PPFIA binding protein 1

increases expression

ISO

Cocaine results in increased expression of PPFIBP1 mRNA

NCBI chr 4:181,538,249...181,682,079
Ensembl chr 4:181,539,450...181,682,076

G

peptidylprolyl isomerase B

increases expression

EXP

Cocaine results in increased expression of PPIB mRNA

NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:75,498,797...75,504,847

G

peptidylprolyl isomerase D

increases expression

ISO

Cocaine results in increased expression of PPID mRNA

NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:167,025,931...167,054,493

G

protein phosphatase 1 catalytic subunit alpha

decreases expression

ISO

Cocaine results in decreased expression of PPP1CA mRNA

NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:210,914,567...210,918,193

G

protein phosphatase 1, regulatory subunit 12A

affects expression

EXP

Cocaine affects the expression of PPP1R12A mRNA

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

protein phosphatase 1, regulatory subunit 15A

increases expression

EXP

Cocaine results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions
increases phosphorylation
affects phosphorylation
increases response to substance
affects response to substance
increases expression

ISO
EXP

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone]; Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Corticosterone]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of PPP1R1B protein]; PPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]; resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
Cocaine affects the phosphorylation of PPP1R1B protein
6-methyl-2-(phenylethynyl)pyridine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]; Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of PPP1R1B protein]; roscovitine affects the reaction [Cocaine affects the phosphorylation of PPP1R1B protein]
PPP1R1B gene mutant form results in increased susceptibility to Cocaine; PPP1R1B mutant form results in increased susceptibility to Cocaine
PPP1R1B affects the susceptibility to Cocaine

PMID:10103106 PMID:10516482 PMID:11268215 PMID:15287884 PMID:15665076 More...

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063

G

protein phosphatase 1, regulatory subunit 7

increases expression
multiple interactions

ISO

Cocaine results in increased expression of PPP1R7 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PPP1R7 mRNA]

NCBI chr 9:101,333,472...101,358,589
Ensembl chr 9:101,333,497...101,360,959

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

ISO

Cocaine results in decreased expression of PPP2CA mRNA

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 2 catalytic subunit beta

decreases expression

ISO

Cocaine results in decreased expression of PPP2CB mRNA

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634

G

protein phosphatase 2, regulatory subunit B, beta

affects expression

EXP

Cocaine affects the expression of PPP2R2B mRNA

NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,904,686...35,356,977

G

protein phosphatase 2, regulatory subunit B, gamma

decreases expression

ISO

Cocaine results in decreased expression of PPP2R2C mRNA

NCBI chr14:78,071,274...78,156,212
Ensembl chr14:78,071,274...78,156,212

G

protein phosphatase 3 catalytic subunit alpha

affects expression

EXP

Cocaine affects the expression of PPP3CA mRNA

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

protein phosphatase 3, regulatory subunit B, beta

decreases expression

EXP

Cocaine results in decreased expression of PPP3R2 mRNA

NCBI chr 5:68,822,387...68,823,382
Ensembl chr 5:68,822,387...68,823,818

G

protein phosphatase 5, catalytic subunit

increases expression

EXP

Cocaine results in increased expression of PPP5C protein

NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950

G

protein phosphatase 6, catalytic subunit

affects expression

EXP

Cocaine affects the expression of PPP6C mRNA

NCBI chr 3:43,339,521...43,371,807
Ensembl chr 3:43,341,108...43,371,807

G

polyglutamine binding protein 1

affects expression

EXP

Cocaine affects the expression of PQBP1 mRNA

NCBI chr X:17,275,445...17,280,018
Ensembl chr X:17,275,759...17,280,016

G

PR/SET domain 2

increases expression

EXP

Cocaine results in increased expression of PRDM2 mRNA

NCBI chr 5:160,704,396...160,815,184
Ensembl chr 5:160,705,462...160,815,140

G

peroxiredoxin 2

affects expression
decreases expression

ISO

Cocaine affects the expression of PRDX2 protein
Cocaine results in decreased expression of PRDX2 protein

PMID:17075605 PMID:19393250

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

peroxiredoxin 5

affects expression

ISO

Cocaine affects the expression of PRDX5 protein

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:213,529,035...213,533,020

G

prolyl endopeptidase-like

increases expression

ISO

Cocaine results in increased expression of PREPL mRNA

NCBI chr 6:15,333,107...15,362,825
Ensembl chr 6:15,333,077...15,363,231

G

prickle planar cell polarity protein 2

increases expression

EXP

Cocaine results in increased expression of PRICKLE2 mRNA

NCBI chr 4:126,426,767...126,771,986
Ensembl chr 4:126,426,771...126,772,008

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions
affects expression
affects activity

EXP

[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of DPYSL2 protein; [Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of GNAO1 protein alternative form; Cocaine affects the activity of and affects the expression of PRKACA protein
Cocaine affects the expression of PRKACA protein

PMID:12595601 PMID:15659224 PMID:19457111

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

protein kinase C, alpha

increases expression
decreases expression
multiple interactions

EXP
ISO

Cocaine results in increased expression of PRKCA protein
Cocaine results in decreased expression of PRKCA mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of PRKCA mRNA]

PMID:12808488 PMID:18355967

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of PRKCB mRNA
Cocaine results in increased expression of PRKCB mRNA

PMID:12629581 PMID:17898221

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, delta

multiple interactions
increases cleavage

ISO

Cocaine results in increased expression of and results in increased cleavage of PRKCD protein; GPX1 affects the reaction [Cocaine results in increased cleavage of PRKCD protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; PRKCD protein affects the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; PRKCD protein affects the reaction [Cocaine results in increased activity of GPT protein]; PRKCD protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; PRKCD protein affects the reaction [Cocaine results in increased expression of GCLC mRNA]; PRKCD protein affects the reaction [Cocaine results in increased expression of GCLM mRNA]

PMID:30027653 PMID:30393195

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase C, epsilon

affects expression
decreases phosphorylation
decreases expression

EXP

Cocaine affects the expression of PRKCE mRNA
Cocaine results in decreased phosphorylation of PRKCE protein
Cocaine results in decreased expression of PRKCE protein

PMID:15677681 PMID:20187946

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, gamma

increases expression

EXP

Cocaine results in increased expression of PRKCG mRNA

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814

G

protein kinase C, zeta

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PRKCZ mRNA

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

prolactin

affects expression
decreases expression
increases expression
decreases secretion
affects secretion
multiple interactions

ISO
EXP

Cocaine affects the expression of PRL protein
cocaine decreases expression of Prl protein in blood plasma
Cocaine results in decreased expression of PRL protein
Cocaine results in increased expression of PRL protein
Cocaine results in decreased secretion of PRL protein
Cocaine affects the secretion of PRL protein
Cocaine affects the reaction [Fenfluramine results in increased expression of PRL protein]; Cocaine inhibits the reaction [1-(3-chlorophenyl)piperazine results in increased expression of PRL protein]

CTD
RGD

PMID:2584360 PMID:10349036 PMID:12892653 PMID:12893845 PMID:14512708 More...

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protamine 1

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of PRM1 mRNA]

NCBI chr10:5,378,740...5,379,235

G

protein arginine methyltransferase 1

decreases expression
decreases expression

ISO

Cocaine results in decreased expression of PRMT1 mRNA
cocaine decreases expression of Prmt1 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827

G

protein arginine methyltransferase 2

decreases expression
decreases expression

ISO

Cocaine results in decreased expression of PRMT2 mRNA
cocaine decreases expression of Prmt2 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr20:12,391,388...12,420,096
Ensembl chr20:12,394,268...12,420,108

G

protein arginine methyltransferase 5

decreases expression
decreases expression

ISO

Cocaine results in decreased expression of PRMT5 mRNA
cocaine decreases expression of Prmt5 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr15:31,938,927...31,948,318
Ensembl chr15:31,938,719...31,948,426

G

protein arginine methyltransferase 6

decreases expression
decreases expression
multiple interactions
affects response to substance

ISO
EXP

Cocaine results in decreased expression of PRMT6 mRNA; Cocaine results in decreased expression of PRMT6 protein
cocaine decreases expression of Prmt6 mRNA and protein in nucleus accumbens
PRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]
PRMT6 protein affects the susceptibility to Cocaine

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr 2:200,615,780...200,620,790
Ensembl chr 2:200,614,979...200,623,308

G

protein arginine methyltransferase 8

decreases expression
decreases expression

ISO

Cocaine results in decreased expression of PRMT8 mRNA
cocaine decreases expression of Prmt8 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr 4:162,221,986...162,304,036
Ensembl chr 4:162,221,986...162,307,310

G

protein arginine methyltransferase 9

decreases expression
decreases expression

ISO

Cocaine results in decreased expression of PRMT9 mRNA
cocaine decreases expression of Prmt9 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr19:47,257,974...47,318,719
Ensembl chr19:47,284,351...47,318,682

G

proline dehydrogenase 2

increases expression

EXP

Cocaine results in increased expression of PRODH2 mRNA

NCBI chr 1:94,881,000...94,894,609
Ensembl chr 1:94,881,061...94,894,609

G

prominin 2

decreases expression

EXP

Cocaine results in decreased expression of PROM2 mRNA

NCBI chr 3:135,200,944...135,215,130
Ensembl chr 3:135,200,944...135,215,077

G

proline rich protein 2

increases expression

EXP

Cocaine results in increased expression of PRP2 mRNA

NCBI chr 4:167,331,491...167,335,068
Ensembl chr 4:167,331,491...167,335,068

G

pre-mRNA processing factor 18

increases expression
multiple interactions

ISO

Cocaine results in increased expression of PRPF18 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of PRPF18 mRNA]

NCBI chr17:78,539,004...78,570,483
Ensembl chr17:78,539,839...78,600,250

G

pre-mRNA processing factor 19

affects expression

EXP

Cocaine affects the expression of PRPF19 mRNA

NCBI chr 1:216,966,104...216,977,549
Ensembl chr 1:216,966,462...216,980,506

G

proline-rich transmembrane protein 1

affects expression

EXP

Cocaine affects the expression of PRRT1 mRNA

NCBI chr20:4,122,565...4,126,386
Ensembl chr20:4,122,508...4,126,213

G

proteinase 3

multiple interactions

ISO

Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to PRTN3 protein]

NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:10,472,755...10,482,474

G

proteasome 20S subunit beta 7

decreases expression

EXP

Cocaine results in decreased expression of PSMB7 protein

NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:42,767,501...42,827,601

G

proteasome activator subunit 4

increases expression

ISO

Cocaine results in increased expression of PSME4 mRNA

NCBI chr14:108,706,643...108,810,330
Ensembl chr14:108,706,643...108,810,328

G

phosphatidylserine synthase 1

affects expression

EXP

Cocaine affects the expression of PTDSS1 mRNA

NCBI chr 7:65,730,250...65,792,024
Ensembl chr 7:65,729,629...65,794,359

G

phosphatase and tensin homolog

affects expression

ISO

Cocaine affects the expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

protein tyrosine kinase 2

decreases expression
decreases phosphorylation

ISO

Cocaine results in decreased expression of PTK2 mRNA
Cocaine results in decreased phosphorylation of PTK2 protein

PMID:12629581 PMID:27506785

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

protein tyrosine kinase 2 beta

increases expression

EXP

Cocaine results in increased expression of PTK2B protein

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

pleiotrophin

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of PTN mRNA
Cocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form]

PMID:12629581 PMID:24096156

NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482

G

PTOV1, extended AT-hook containing adaptor protein

affects expression

EXP

Cocaine affects the expression of PTOV1 mRNA

NCBI chr 1:104,483,553...104,496,161
Ensembl chr 1:104,483,556...104,490,101

G

protein tyrosine phosphatase, non-receptor type 3

affects expression

EXP

Cocaine affects the expression of PTPN3 mRNA

NCBI chr 5:76,703,687...76,822,584
Ensembl chr 5:76,703,687...76,860,470

G

protein tyrosine phosphatase, receptor type, A

decreases expression

ISO

Cocaine results in decreased expression of PTPRA mRNA

NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126

G

protein tyrosine phosphatase, receptor type, B

decreases expression

ISO

Cocaine results in decreased expression of PTPRB mRNA

NCBI chr 7:53,816,197...53,920,760
Ensembl chr 7:53,816,097...53,920,760

G

purine rich element binding protein B

affects expression

EXP

Cocaine affects the expression of PURB mRNA

NCBI chr14:85,556,296...85,558,779
Ensembl chr14:85,550,417...85,572,205

G

parvalbumin

decreases expression
affects expression

ISO
EXP

Cocaine results in decreased expression of PVALB protein
Cocaine affects the expression of PVALB protein

PMID:15219666 PMID:17075605

NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446

G

quinolinate phosphoribosyltransferase

affects expression

EXP

Cocaine affects the expression of QPRT mRNA

NCBI chr 1:191,148,715...191,164,006
Ensembl chr 1:191,148,713...191,194,162

G

queuine tRNA-ribosyltransferase catalytic subunit 1

affects expression

EXP

Cocaine affects the expression of QTRT1 mRNA

NCBI chr 8:28,239,993...28,249,983
Ensembl chr 8:28,242,472...28,250,398

G

R3H domain containing 2

affects expression

EXP

Cocaine affects the expression of R3HDM2 mRNA

NCBI chr 7:65,097,685...65,225,863
Ensembl chr 7:65,097,923...65,225,862

G

RAB12, member RAS oncogene family

decreases expression

EXP

Cocaine results in decreased expression of RAB12 mRNA

NCBI chr 9:113,927,119...113,953,722
Ensembl chr 9:113,927,119...113,953,695

G

RAB14, member RAS oncogene family

affects expression

EXP

Cocaine affects the expression of RAB14 mRNA

NCBI chr 3:38,899,430...38,920,572
Ensembl chr 3:38,901,400...38,912,273

G

RAB15, member RAS oncogene family

affects expression

EXP

Cocaine affects the expression of RAB15 mRNA

NCBI chr 6:101,232,740...101,257,388
Ensembl chr 6:101,232,743...101,257,083

G

RAB31, member RAS oncogene family

affects expression

EXP

Cocaine affects the expression of RAB31 mRNA

NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:112,693,597...112,828,092

G

RAB3A, member RAS oncogene family

increases expression

EXP

Cocaine results in increased expression of RAB3A mRNA

NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842

G

RAB3C, member RAS oncogene family

increases expression

EXP

Cocaine results in increased expression of RAB3C mRNA

NCBI chr 2:43,353,822...43,577,226
Ensembl chr 2:43,361,093...43,577,022

G

Rac family small GTPase 1

affects expression
increases expression

EXP
ISO

Cocaine affects the expression of RAC1 mRNA
Cocaine results in increased expression of RAC1 protein

PMID:18952886 PMID:20187946

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

EXP

[[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein; [Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

retinoic acid induced 14

increases expression

EXP

Cocaine results in increased expression of RAI14 mRNA

NCBI chr 2:61,273,439...61,411,141
Ensembl chr 2:61,273,439...61,409,791

G

Ral GEF with PH domain and SH3 binding motif 2

increases expression

EXP

Cocaine results in increased expression of RALGPS2 mRNA

NCBI chr13:71,474,835...71,654,791
Ensembl chr13:71,474,835...71,606,739

G

Rap guanine nucleotide exchange factor 4

affects expression

EXP

Cocaine affects the expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

Rap guanine nucleotide exchange factor 6

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of RAPGEF6 mRNA]

NCBI chr10:39,156,573...39,324,947
Ensembl chr10:39,156,620...39,324,946

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression
increases expression

EXP

Cocaine affects the expression of RASGRF1 mRNA
Cocaine results in increased expression of RASGRF1 protein

PMID:17931779 PMID:20187946

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

RAS-like family 11 member A

increases expression

EXP

Cocaine results in increased expression of RASL11A mRNA

NCBI chr12:13,372,023...13,374,784
Ensembl chr12:13,372,023...13,376,451

G

RAS-like, family 2, locus 9

affects expression

EXP

Cocaine affects the expression of RASL2-9 mRNA

NCBI chr 1:77,749,728...77,750,905
Ensembl chr 1:77,749,091...77,751,537

G

RNA binding motif protein 12

affects expression

EXP

Cocaine affects the expression of RBM12 mRNA

NCBI chr 3:165,069,744...165,089,994
Ensembl chr 3:165,042,878...165,090,021

G

RNA binding motif protein 14

decreases expression
affects expression

EXP

Cocaine results in decreased expression of RBM14 mRNA
Cocaine affects the expression of RBM14 mRNA

PMID:17898221 PMID:20187946

NCBI chr 1:211,476,298...211,535,077
Ensembl chr 1:211,523,972...211,535,065

G

RNA binding motif protein 26

affects expression

EXP

Cocaine affects the expression of RBM26 mRNA

NCBI chr15:88,299,378...88,379,365
Ensembl chr15:88,301,436...88,378,686

G

RNA binding motif protein 42

affects expression

EXP

Cocaine affects the expression of RBM42 mRNA

NCBI chr 1:95,026,050...95,036,020
Ensembl chr 1:95,026,050...95,035,980

G

RCSD domain containing 1

increases expression

EXP

Cocaine results in increased expression of RCSD1 mRNA

NCBI chr13:80,434,878...80,497,312
Ensembl chr13:80,434,878...80,498,931

G

retinol dehydrogenase 10

affects expression

EXP

Cocaine affects the expression of RDH10 mRNA

NCBI chr 5:7,969,931...7,998,834
Ensembl chr 5:7,971,705...7,999,019

G

reversion-inducing-cysteine-rich protein with kazal motifs

increases expression

ISO

Cocaine results in increased expression of RECK protein

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270

G

RecQ like helicase

affects expression

EXP

Cocaine affects the expression of RECQL mRNA

NCBI chr 4:177,039,351...177,063,968
Ensembl chr 4:177,035,128...177,063,838

G

regenerating family member 3 gamma

decreases expression

EXP

Cocaine results in decreased expression of REG3G mRNA

NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:112,482,183...112,484,738

G

REL proto-oncogene, NF-kB subunit

affects expression
decreases activity

EXP

Cocaine affects the expression of REL protein
Cocaine results in decreased activity of REL protein

PMID:16179556 PMID:20477932

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
increases localization

ISO
EXP

acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; Cocaine promotes the reaction [RELA protein binds to CCL2 promoter]; Cocaine results in increased activity of and affects the localization of RELA protein; Cocaine results in increased phosphorylation of and results in increased activity of RELA protein; GPX1 protein inhibits the reaction [Cocaine affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in increased activity of and affects the localization of RELA protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; RELA mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]
Cocaine results in increased activity of RELA protein
SCH 23390 inhibits the reaction [Cocaine results in increased activity of RELA protein]
Cocaine results in increased localization of RELA protein
[cocaine cotreated with ceftriaxone] increases expression of Rela protein in hippocampus and dorsal striatum

CTD
RGD

PMID:19183502 PMID:20354174 PMID:31059705 PMID:31100299

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RELT-like 2

affects expression

EXP

Cocaine affects the expression of RELL2 mRNA

NCBI chr18:30,041,204...30,045,193
Ensembl chr18:30,041,563...30,045,187

G

reelin

increases expression

EXP

Cocaine results in increased expression of RELN mRNA

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

reticulophagy regulator family member 2

affects expression

EXP

Cocaine affects the expression of RETREG2 mRNA

NCBI chr 9:84,088,935...84,095,072
Ensembl chr 9:84,088,964...84,094,837

G

regulator of G-protein signaling 2

affects expression
increases expression

EXP

Cocaine affects the expression of RGS2 mRNA
Cocaine results in increased expression of RGS2 mRNA

PMID:10098858 PMID:20187946

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

regulator of G-protein signaling 20

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of RGS20 mRNA]

NCBI chr 5:19,282,249...19,412,122
Ensembl chr 5:19,282,153...19,413,286

G

regulator of G-protein signaling 4

decreases expression
affects expression
increases expression

EXP

Cocaine results in decreased expression of RGS4 mRNA
Cocaine affects the expression of RGS4 mRNA
Cocaine results in increased expression of RGS4 mRNA

PMID:12270694 PMID:17632279 PMID:20187946

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

regulator of G-protein signaling 9

affects expression

EXP

Cocaine affects the expression of RGS9 mRNA

NCBI chr10:94,696,556...94,770,387
Ensembl chr10:94,696,556...94,770,387

G

ras homolog family member A

multiple interactions

EXP

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to RHOA protein]; [Cocaine co-treated with Cocaine deficiency] results in decreased ubiquitination of RHOA protein; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in decreased activity of RHOA protein

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

ras homolog family member G

affects expression

EXP

Cocaine affects the expression of RHOG mRNA

NCBI chr 1:166,030,685...166,046,254
Ensembl chr 1:166,017,427...166,044,787

G

ras homolog family member T2

affects expression

EXP

Cocaine affects the expression of RHOT2 mRNA

NCBI chr10:15,363,467...15,369,263
Ensembl chr10:15,361,726...15,369,006

G

ring finger protein 1

affects expression

EXP

Cocaine affects the expression of RING1 mRNA

NCBI chr20:4,832,013...4,835,516
Ensembl chr20:4,831,993...4,835,513

G

receptor interacting serine/threonine kinase 1

decreases expression

EXP

Cocaine results in decreased expression of RIPK1 mRNA

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

Rho family GTPase 2

affects expression

ISO

Cocaine affects the expression of RND2 mRNA

NCBI chr10:86,899,395...86,902,992
Ensembl chr10:86,899,395...86,902,992

G

Rho family GTPase 3

increases expression

ISO

Cocaine results in increased expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536

G

ring finger protein 14

increases expression

EXP

Cocaine results in increased expression of RNF14 protein

NCBI chr18:30,381,072...30,406,859
Ensembl chr18:30,382,857...30,406,774

G

ring finger protein 32

affects expression

EXP

Cocaine affects the expression of RNF32 mRNA

NCBI chr 4:6,822,700...6,884,411
Ensembl chr 4:6,824,970...6,883,976

G

Ro60, Y RNA binding protein

decreases expression

EXP

Cocaine results in decreased expression of RO60 mRNA

NCBI chr13:58,049,838...58,070,828
Ensembl chr13:58,049,858...58,076,264

G

Rho-associated coiled-coil containing protein kinase 2

affects expression

EXP

Cocaine affects the expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

RAR-related orphan receptor B

increases expression

ISO

Cocaine results in increased expression of RORB mRNA

NCBI chr 1:225,790,216...225,970,973
Ensembl chr 1:225,790,216...225,970,973

G

ribosomal protein L10

affects expression

EXP

Cocaine affects the expression of RPL10 mRNA

NCBI chr X:157,205,850...157,208,057
Ensembl chr X:157,205,836...157,208,049

G

ribosomal protein L19

affects expression

EXP

Cocaine affects the expression of RPL19 mRNA

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352

G

ribosomal protein L32

affects expression

EXP

Cocaine affects the expression of RPL32 mRNA

NCBI chr 4:150,536,650...150,540,214
Ensembl chr 4:150,536,646...150,540,214

G

ribosomal protein L36

affects expression

EXP

Cocaine affects the expression of RPL36 mRNA

NCBI chr 9:1,529,117...1,534,534
Ensembl chr 1:126,560,003...126,560,369

G

ribosomal protein L6

affects expression

EXP

Cocaine affects the expression of RPL6 mRNA

NCBI chr12:41,008,142...41,012,756
Ensembl chr12:41,008,142...41,025,733

G

ribosomal protein L9

decreases expression

EXP

Cocaine results in decreased expression of RPL9 mRNA

NCBI chr14:43,247,536...43,250,784
Ensembl chr14:43,247,588...43,250,782
Ensembl chr 1:43,247,588...43,250,782

G

ribosomal protein L9, pseudogene 18

decreases expression

EXP

Cocaine results in decreased expression of RPL9-PS18 mRNA

NCBI chr18:78,384,038...78,384,607

G

ribosomal protein L9, pseudogene 20

decreases expression

EXP

Cocaine results in decreased expression of RPL9-PS20 mRNA

NCBI chr20:13,750,665...13,751,646
Ensembl chr20:13,750,686...13,751,642

G

ribosomal protein L9, pseudogene 28

decreases expression

EXP

Cocaine results in decreased expression of RPL9-PS28 mRNA

NCBI chr 3:135,124,168...135,125,039

G

ribosomal protein L9 like 1

decreases expression

EXP

Cocaine results in decreased expression of RPL9L1 mRNA

NCBI chr14:24,002,758...24,003,468

G

ribosomal protein S10

affects expression
decreases expression

EXP
ISO

Cocaine affects the expression of RPS10 mRNA
Cocaine results in decreased expression of RPS10 mRNA

PMID:15009677 PMID:20187946

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S16

affects expression

EXP

Cocaine affects the expression of RPS16 mRNA

NCBI chr 1:92,770,658...92,773,603
Ensembl chr19:56,922,246...56,923,020
Ensembl chr 1:56,922,246...56,923,020

G

ribosomal protein S6 kinase A1

multiple interactions

EXP

Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA1 protein

NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044

G

ribosomal protein S6 kinase A3

multiple interactions

ISO

RPS6KA3 affects the reaction [Cocaine results in increased phosphorylation of FOS protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased expression of PDYN protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]

NCBI chr X:39,325,926...39,432,017
Ensembl chr X:39,325,926...39,433,678

G

ribosomal protein S6 kinase A5

increases expression
affects response to substance
increases activity
multiple interactions

EXP
ISO

Cocaine results in increased expression of RPS6KA5 mRNA; Cocaine results in increased expression of RPS6KA5 protein
RPS6KA5 affects the susceptibility to Cocaine
Cocaine results in increased activity of RPS6KA5 protein
Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]

PMID:16339038 PMID:17898221 PMID:25100957

NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856

G

ribosomal protein S9

decreases expression

ISO

Cocaine results in decreased expression of RPS9 mRNA

NCBI chr 1:74,427,084...74,430,513
Ensembl chr 1:74,427,087...74,430,105

G

ribosomal protein SA

decreases expression

ISO

Cocaine results in decreased expression of RPSA mRNA

NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737

G

round spermatid basic protein 1-like

increases expression

EXP

Cocaine results in increased expression of RSBN1L mRNA

NCBI chr 4:15,014,405...15,093,287
Ensembl chr 4:15,031,173...15,093,286

G

radial spoke head component 1

increases expression

EXP

Cocaine results in increased expression of RSPH1 mRNA

NCBI chr20:9,343,258...9,361,988
Ensembl chr20:9,343,261...9,361,988

G

RT1 class I, locus CE9, pseudogene 1

increases expression

EXP

Cocaine results in increased expression of RT1-CE9-PS1 mRNA

NCBI chr20:3,408,333...3,411,522

G

RT1 class II, locus Da

affects expression

EXP

Cocaine affects the expression of RT1-DA mRNA

NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383

G

rhotekin

affects expression

EXP

Cocaine affects the expression of RTKN mRNA

NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:117,198,647...117,215,660

G

reticulon 4 interacting protein 1

increases expression

EXP

Cocaine results in increased expression of RTN4IP1 protein

NCBI chr20:48,964,903...49,004,235
Ensembl chr20:48,964,816...49,006,456

G

RUNX family transcription factor 1

affects expression

EXP

Cocaine affects the expression of RUNX1 mRNA

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

RUNX1 partner transcriptional co-repressor 1

increases expression

EXP

Cocaine results in increased expression of RUNX1T1 mRNA

NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:31,984,855...32,132,855

G

RUNX family transcription factor 2

multiple interactions

EXP

[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to DNM1L promoter]; [Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to EGR3 promoter]; [Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to SMARCA4 promoter]; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased activity of RUNX2 protein

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

RING1 and YY1 binding protein

increases expression

ISO

Cocaine results in increased expression of RYBP mRNA

NCBI chr 4:134,432,663...134,484,732
Ensembl chr 4:134,432,663...134,484,930

G

ryanodine receptor 2

affects expression
increases expression

EXP
ISO

Cocaine affects the expression of RYR2 mRNA
Cocaine results in increased expression of RYR2 mRNA

PMID:20187946 PMID:21113126

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705

G

ryanodine receptor 3

affects expression

EXP

Cocaine affects the expression of RYR3 mRNA

NCBI chr 3:119,886,129...120,433,465
Ensembl chr 3:119,885,878...120,433,677

G

S100 calcium binding protein B

multiple interactions
affects expression

EXP

ipsapirone inhibits the reaction [Cocaine affects the expression of S100B protein]

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

sphingosine-1-phosphate receptor 2

decreases expression

EXP

Cocaine results in decreased expression of S1PR2 mRNA

NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:27,774,566...27,790,577

G

S-antigen visual arrestin

affects expression

EXP

Cocaine affects the expression of SAG mRNA

NCBI chr 9:95,915,640...95,956,641
Ensembl chr 9:95,917,197...95,956,507

G

secretion associated, Ras related GTPase 1A

affects expression

EXP

Cocaine affects the expression of SAR1A mRNA

NCBI chr20:30,166,310...30,178,718
Ensembl chr20:30,166,334...30,178,710

G

spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

affects expression

EXP

Cocaine affects the expression of SART1 mRNA

NCBI chr 1:212,119,824...212,128,517
Ensembl chr 1:212,104,557...212,128,486

G

SATB homeobox 1

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of SATB1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SATB1 mRNA]

NCBI chr 9:4,916,958...5,010,359
Ensembl chr 9:4,917,215...4,989,925

G

SATB homeobox 2

multiple interactions
decreases expression

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of SATB2 mRNA
Cocaine results in decreased expression of SATB2 mRNA

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:65,844,570...66,021,238

G

strawberry notch homolog 1

increases expression

EXP

Cocaine results in increased expression of SBNO1 mRNA

NCBI chr12:37,835,306...37,895,861
Ensembl chr12:37,846,514...37,891,231

G

suprabasin

increases expression
multiple interactions

ISO

Cocaine results in increased expression of SBSN mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SBSN mRNA]

NCBI chr 1:95,106,390...95,133,448
Ensembl chr 1:95,120,927...95,134,220

G

scavenger receptor class B, member 1

increases expression

ISO

Cocaine results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

secretogranin II

increases expression

EXP

Cocaine results in increased expression of SCG2 mRNA; Cocaine results in increased expression of SCG2 protein

PMID:19918966 PMID:27899881

NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598

G

sodium voltage-gated channel alpha subunit 10

affects expression

EXP

Cocaine affects the expression of SCN10A mRNA

NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298

G

sodium voltage-gated channel beta subunit 2

increases expression

EXP

Cocaine results in increased expression of SCN2B mRNA

NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:54,322,383...54,334,519

G

SCY1 like pseudokinase 1

affects expression

EXP

Cocaine affects the expression of SCYL1 mRNA

NCBI chr 1:212,475,198...212,489,285
Ensembl chr 1:212,475,068...212,501,129

G

SDA1 domain containing 1

increases expression

EXP

Cocaine results in increased expression of SDAD1 mRNA

NCBI chr14:16,025,726...16,052,565
Ensembl chr14:16,025,727...16,055,359

G

Sec61 translocon subunit gamma, pseudogene 3

decreases expression

EXP

Cocaine results in decreased expression of SEC61G-PS3 mRNA

NCBI chr 1:205,320,831...205,355,458

G

selenoprotein S

affects expression

EXP

Cocaine affects the expression of SELENOS mRNA

NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:129,070,230...129,077,991

G

selectin P

affects localization

ISO

Cocaine affects the localization of SELP protein

PMID:7689042 PMID:10814631

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987

G

semaphorin 3A

decreases expression

EXP

Cocaine results in decreased expression of SEMA3A mRNA

NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:22,245,322...22,535,774

G

semaphorin 3B

increases expression

ISO
EXP

Cocaine results in increased expression of SEMA3B mRNA

PMID:15691709 PMID:17205118

NCBI chr 8:117,150,307...117,161,570
Ensembl chr 8:117,150,589...117,157,658

G

semaphorin 3C

affects expression

EXP

Cocaine affects the expression of SEMA3C mRNA

NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:18,538,454...18,701,740

G

semaphorin 3E

affects expression

EXP

Cocaine affects the expression of SEMA3E mRNA

NCBI chr 4:21,252,686...21,510,449
Ensembl chr 4:21,210,734...21,510,374

G

semaphorin 3F

affects expression

EXP

Cocaine affects the expression of SEMA3F mRNA

NCBI chr 8:117,236,269...117,265,206
Ensembl chr 8:117,236,269...117,265,206

G

semaphorin 4A

affects expression

EXP

Cocaine affects the expression of SEMA4A mRNA

NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:176,194,255...176,212,258

G

semaphorin 4B

increases expression

EXP

Cocaine results in increased expression of SEMA4B mRNA

NCBI chr 1:143,545,727...143,587,037
Ensembl chr 1:143,537,690...143,587,037

G

semaphorin 4C

increases expression

EXP

Cocaine results in increased expression of SEMA4C mRNA

NCBI chr 9:46,287,540...46,298,041
Ensembl chr 9:46,287,542...46,297,998

G

semaphorin 4D

affects expression

EXP

Cocaine affects the expression of SEMA4D mRNA

NCBI chr17:13,582,085...13,688,889
Ensembl chr17:13,582,098...13,688,891

G

semaphorin 4F

increases expression

EXP

Cocaine results in increased expression of SEMA4F mRNA

NCBI chr 4:116,969,137...116,995,442
Ensembl chr 4:116,969,137...116,995,442

G

semaphorin 4G

affects expression

EXP

Cocaine affects the expression of SEMA4G mRNA

NCBI chr 1:253,799,552...253,814,504
Ensembl chr 1:253,800,099...253,814,503

G

semaphorin 5A

affects expression

EXP

Cocaine affects the expression of SEMA5A mRNA

NCBI chr 2:85,020,724...85,451,938
Ensembl chr 2:85,020,724...85,451,938

G

semaphorin 5B

affects expression

EXP

Cocaine affects the expression of SEMA5B mRNA

NCBI chr11:78,607,805...78,730,724
Ensembl chr11:78,607,805...78,730,589

G

semaphorin 6A

decreases expression
increases expression

ISO
EXP

Cocaine results in decreased expression of SEMA6A mRNA
Cocaine results in increased expression of SEMA6A mRNA

PMID:15691709 PMID:18000554

NCBI chr18:42,237,227...42,358,540
Ensembl chr18:42,237,228...42,358,540

G

semaphorin 6B

increases expression

EXP

Cocaine results in increased expression of SEMA6B mRNA

NCBI chr 9:1,038,103...1,055,063
Ensembl chr 9:1,038,103...1,048,868

G

semaphorin 6C

decreases expression

EXP

Cocaine results in decreased expression of SEMA6C mRNA

NCBI chr 2:185,422,636...185,436,237
Ensembl chr 2:185,422,639...185,448,689

G

semaphorin 7A (John Milton Hagen blood group)

affects expression

EXP

Cocaine affects the expression of SEMA7A mRNA

NCBI chr 8:67,244,318...67,267,060
Ensembl chr 8:67,243,824...67,267,058

G

septin 2

affects expression

EXP

Cocaine affects the expression of SEPTIN2 mRNA

NCBI chr 9:101,465,535...101,498,766
Ensembl chr 9:101,465,650...101,498,759

G

septin 4

decreases expression

ISO

Cocaine results in decreased expression of SEPTIN4 mRNA

PMID:12629581 PMID:15009677 PMID:16710320

NCBI chr10:72,863,969...72,888,018
Ensembl chr10:72,864,014...72,888,019

G

septin 8

decreases expression

EXP

Cocaine results in decreased expression of SEPTIN8 protein

NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504

G

serpin family F member 2

increases expression

EXP

Cocaine results in increased expression of SERPINF2 mRNA

NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,770,698...60,778,996

G

serpin family I member 1

increases expression

EXP

Cocaine results in increased expression of SERPINI1 mRNA

NCBI chr 2:162,645,209...162,731,737
Ensembl chr 2:162,645,350...162,731,740

G

SERTA domain containing 1

affects expression

EXP

Cocaine affects the expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001

G

seizure related 6 homolog like

decreases expression
multiple interactions

ISO

Cocaine results in decreased expression of SEZ6L mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SEZ6L mRNA]

NCBI chr12:49,725,330...49,882,222
Ensembl chr12:49,725,330...49,882,222

G

SFT2 domain containing 2

decreases expression

EXP

Cocaine results in decreased expression of SFT2D2 mRNA

NCBI chr13:80,017,854...80,037,144
Ensembl chr13:80,008,480...80,037,473

G

sarcoglycan, beta

increases expression
decreases expression

ISO

Cocaine results in increased expression of SGCB mRNA
Cocaine results in decreased expression of SGCB mRNA

PMID:12629581 PMID:18000554

NCBI chr14:34,917,663...34,932,661
Ensembl chr14:34,912,628...34,933,666

G

serum/glucocorticoid regulated kinase 1

affects expression

EXP

Cocaine affects the expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

serum/glucocorticoid regulated kinase family, member 3

increases expression

ISO

Cocaine results in increased expression of SGK3 mRNA

NCBI chr 5:14,128,628...14,255,099
Ensembl chr 5:14,126,257...14,198,331

G

SH3 domain containing GRB2 like 1, endophilin A2

affects expression

EXP

Cocaine affects the expression of SH3GL1 mRNA

NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890

G

SH3 and multiple ankyrin repeat domains 2

decreases expression

ISO

Cocaine results in decreased expression of SHANK2 mRNA

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of SHANK3 mRNA

NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:122,448,323...122,510,410

G

shisa like 2B

decreases expression

EXP

Cocaine results in decreased expression of SHISAL2B mRNA

NCBI chr 2:37,736,377...37,754,126
Ensembl chr 2:37,736,387...37,753,212

G

sigma non-opioid intracellular receptor 1

multiple interactions
increases response to substance
decreases response to substance
affects binding

ISO

1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein]; Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
SIGMAR1 mRNA results in increased susceptibility to Cocaine
SIGMAR1 gene mutant form results in decreased susceptibility to Cocaine
Cocaine results in increased activity of and results in increased localization of SIGMAR1 protein; methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased localization of SIGMAR1 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]

PMID:11006959 PMID:11426838 PMID:12128006 PMID:20354174 PMID:20956312

NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855

G

suppressor of IKBKE 1

affects expression

EXP

Cocaine affects the expression of SIKE1 mRNA

NCBI chr 2:193,206,490...193,214,321
Ensembl chr 2:193,206,490...193,217,004

G

SIM bHLH transcription factor 2

decreases expression

EXP

Cocaine results in decreased expression of SIM2 mRNA

NCBI chr11:46,883,859...46,923,305
Ensembl chr11:46,883,859...46,923,305

G

signal-induced proliferation-associated 1 like 1

affects expression

EXP

Cocaine affects the expression of SIPA1L1 mRNA

NCBI chr 6:107,570,569...107,849,613
Ensembl chr 6:107,737,392...107,848,160

G

sirtuin 1

increases expression

EXP

cocaine increases expression of Sirt1 protein in nucleus accumbens

RGD

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

sirtuin 2

increases expression

EXP

cocaine increases expression of Sirt2 protein in caudate putamen

RGD

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499

G

SIVA1, apoptosis-inducing factor

affects expression

ISO

Cocaine affects the expression of SIVA1 mRNA

NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790

G

Src-like-adaptor 2

decreases expression

EXP

Cocaine results in decreased expression of SLA2 mRNA

NCBI chr 3:165,821,164...165,848,087
Ensembl chr 3:165,828,657...165,847,062

G

solute carrier family 10 member 1

increases expression

ISO

Cocaine results in increased expression of SLC10A1 mRNA

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier family 12 member 1

affects expression

EXP

Cocaine affects the expression of SLC12A1 mRNA

NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:132,859,590...132,936,340

G

solute carrier family 12, member 8

affects expression
decreases expression

EXP

Cocaine affects the expression of SLC12A8 mRNA
Cocaine results in decreased expression of SLC12A8 mRNA

PMID:20187946 PMID:27899881

NCBI chr11:80,622,000...80,771,674
Ensembl chr11:80,622,000...80,771,659

G

solute carrier family 14 member 1 (Kidd blood group)

affects expression

EXP

Cocaine affects the expression of SLC14A1 mRNA

NCBI chr18:73,840,568...73,883,925
Ensembl chr18:73,840,569...73,870,489

G

solute carrier family 14 member 2

affects expression

EXP

Cocaine affects the expression of SLC14A2 mRNA

Ensembl chr18:73,887,575...73,953,570

G

solute carrier family 16 member 10

decreases expression

EXP

Cocaine results in decreased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 16 member 3

decreases expression

EXP

Cocaine results in decreased expression of SLC16A3 mRNA

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 16, member 6

decreases expression

EXP

Cocaine results in decreased expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965

G

solute carrier family 16 member 8

decreases expression

EXP

Cocaine results in decreased expression of SLC16A8 mRNA

NCBI chr 7:112,698,701...112,702,496
Ensembl chr 7:112,698,701...112,702,496

G

solute carrier family 17 member 6

increases expression

EXP

Cocaine results in increased expression of SLC17A6 protein

NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498

G

solute carrier family 17 member 7

increases expression

EXP

Cocaine results in increased expression of SLC17A7 protein

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 17 member 8

affects response to substance

ISO

SLC17A8 protein affects the susceptibility to Cocaine

NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:25,881,557...25,935,410

G

solute carrier family 18 member A2

decreases expression
increases expression
affects response to substance

ISO
EXP

Cocaine results in decreased expression of SLC18A2 protein
Cocaine results in increased expression of SLC18A2 protein
SLC18A2 protein affects the susceptibility to Cocaine

PMID:12505801 PMID:12716422 PMID:25100957

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 2

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]
cocaine cotreated with ceftriaxone increases expression of Slc1a2 protein in hippocampus and nucleus accumbens
Cocaine decreases expression of Slc1a2 protein in hippocampus and nucleus accumbens
Propentofylline inhibits the reaction [cocaine decreases expression of Slc1a2 protein in core of nucleus accumbens]

CTD
RGD

PMID:19717140 PMID:31100299 PMID:31100299 PMID:23985782 PMID:23985782

RGD:598150313, RGD:598150313, RGD:598150314, RGD:598150314

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 1 member 4

affects expression

EXP

Cocaine affects the expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 20 member 2

affects expression

EXP

Cocaine affects the expression of SLC20A2 mRNA

NCBI chr16:76,163,315...76,253,881
Ensembl chr16:76,162,922...76,253,881

G

solute carrier family 22, member 14

decreases expression

ISO

Cocaine results in decreased expression of SLC22A14 mRNA

NCBI chr 8:127,772,275...127,794,222
Ensembl chr 8:127,772,275...127,785,993

G

solute carrier family 22, member 25

decreases expression

EXP

Cocaine results in decreased expression of SLC22A25 mRNA; Cocaine results in decreased expression of SLC22A9 mRNA

NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340

G

solute carrier family 23 member 1

affects expression

EXP

Cocaine affects the expression of SLC23A1 mRNA

NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702

G

solute carrier family 24 member 2

affects expression

EXP

Cocaine affects the expression of SLC24A2 mRNA

NCBI chr 5:106,543,867...106,787,810
Ensembl chr 5:106,543,874...106,787,780

G

solute carrier family 24 member 4

increases expression

EXP

Cocaine results in increased expression of SLC24A4 mRNA

NCBI chr 6:127,044,470...127,184,684
Ensembl chr 6:127,044,470...127,184,684

G

solute carrier family 25 member 23

decreases expression

ISO

Cocaine results in decreased expression of SLC25A23 mRNA

NCBI chr 9:1,969,633...1,985,365
Ensembl chr 9:1,969,357...1,985,365

G

solute carrier family 25 member 37

increases expression

ISO

Cocaine results in increased expression of SLC25A37 mRNA

PMID:15009677 PMID:16710320

NCBI chr15:50,944,085...50,986,506
Ensembl chr15:50,946,236...50,986,808

G

solute carrier family 26 member 4

affects expression

EXP

Cocaine affects the expression of SLC26A4 mRNA

NCBI chr 6:53,835,102...53,873,968
Ensembl chr 6:53,835,110...53,873,216

G

solute carrier family 29 member 2

decreases expression

EXP

Cocaine results in decreased expression of SLC29A2 mRNA

NCBI chr 1:211,756,588...211,764,561
Ensembl chr 1:211,757,000...211,764,560

G

solute carrier family 32 member 1

increases expression

EXP

Cocaine results in increased expression of SLC32A1 mRNA

NCBI chr 3:167,687,245...167,691,714
Ensembl chr 3:167,687,098...167,691,731

G

solute carrier family 35 member A3

increases expression

ISO

Cocaine results in increased expression of SLC35A3 mRNA

NCBI chr 2:207,305,008...207,344,225
Ensembl chr 2:207,307,947...207,344,155

G

solute carrier family 35 member B2

affects expression

EXP

Cocaine affects the expression of SLC35B2 mRNA

NCBI chr 9:22,936,031...22,940,114
Ensembl chr 9:22,935,887...22,939,793

G

solute carrier family 39 member 10

decreases expression

EXP

Cocaine results in decreased expression of SLC39A10 mRNA

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:62,370,598...62,454,747

G

solute carrier family 39, member 11

affects expression

EXP

Cocaine affects the expression of SLC39A11 mRNA

NCBI chr10:98,775,155...99,196,302
Ensembl chr10:98,776,525...99,107,368

G

solute carrier family 44 member 1

affects expression

EXP

Cocaine affects the expression of SLC44A1 mRNA

NCBI chr 5:72,857,323...73,037,279
Ensembl chr 5:72,858,759...73,037,279

G

solute carrier family 4 member 10

increases expression

EXP

Cocaine results in increased expression of SLC4A10 protein

NCBI chr 3:67,050,925...67,367,637
Ensembl chr 3:66,770,954...67,367,646

G

solute carrier family 4 member 3

affects expression

EXP

Cocaine affects the expression of SLC4A3 mRNA

NCBI chr 9:84,484,749...84,497,746
Ensembl chr 9:84,485,085...84,497,738

G

solute carrier family 4 member 4

affects expression
increases expression

EXP

Cocaine affects the expression of SLC4A4 mRNA
Cocaine results in increased expression of SLC4A4 mRNA

PMID:17898221 PMID:20187946

NCBI chr14:19,125,394...19,577,379
Ensembl chr14:19,129,264...19,577,435

G

solute carrier family 5 member 3

affects expression

EXP

Cocaine affects the expression of SLC5A3 mRNA

NCBI chr11:44,799,787...44,802,233
Ensembl chr11:44,790,297...44,818,157

G

solute carrier family 66 member 2

affects expression

EXP

Cocaine affects the expression of SLC66A2 mRNA

NCBI chr18:75,976,000...76,014,651
Ensembl chr18:75,977,458...76,014,651

G

solute carrier family 6 member 2

decreases activity
multiple interactions
increases phosphorylation
increases expression
increases response to substance

ISO

Cocaine results in decreased activity of SLC6A2 protein
Cocaine inhibits the reaction [SLC6A2 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A2 protein results in increased import of Fluorescent Dyes]
Cocaine results in increased phosphorylation of SLC6A2 protein
Cocaine results in increased expression of SLC6A2 protein
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of SLC6A2 protein]; SB 203580 inhibits the reaction [Cocaine results in increased expression of SLC6A2 protein]
SLC6A2 protein results in increased susceptibility to Cocaine

PMID:11082428 PMID:15763139 PMID:15911120 PMID:19728366 PMID:25724654 More...

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

solute carrier family 6 member 3

multiple interactions
increases expression
affects response to substance
decreases response to substance
decreases expression
affects expression
increases activity
increases response to substance
affects binding

ISO
EXP

[Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Cocaine] which affects the uptake of Dopamine; Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Cocaine inhibits the reaction [Dopamine results in increased activity of SLC6A3 protein]; Cocaine inhibits the reaction [Melitten results in increased localization of SLC6A3 protein]; Cocaine inhibits the reaction [SLC6A3 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A3 protein results in increased import of Fluorescent Dyes]; Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]; Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium]; Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Cocaine promotes the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]
Cocaine results in increased expression of SLC6A3 mRNA
SLC6A3 gene mutant form results in decreased susceptibility to Cocaine
Cocaine results in decreased expression of SLC6A3 mRNA
Cocaine results in decreased expression of SLC6A3 protein
Cocaine promotes the reaction [SLC6A3 protein affects the uptake of Dopamine]; Cocaine results in increased phosphorylation of and results in increased activity of SLC6A3 protein; vanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein]
Cocaine affects the expression of SLC6A3 mRNA; Cocaine affects the expression of SLC6A3 protein
SLC6A3 mutant form affects the susceptibility to Cocaine; SLC6A3 protein affects the susceptibility to Cocaine
Cocaine results in increased activity of SLC6A3 protein
[Alcohols co-treated with Cocaine] results in increased activity of SLC6A3 protein; Cannabidiol inhibits the reaction [Cocaine results in increased expression of SLC6A3 mRNA]; SLC6A3 mutant form affects the reaction [Cocaine affects the abundance of and affects the uptake of Dopamine]; SLC6A3 protein affects the reaction [[Cocaine co-treated with Alcohols] results in increased uptake of Dopamine]; SLC6A3 protein affects the reaction [Cocaine results in increased uptake of Dopamine]
SLC6A3 gene polymorphism results in increased susceptibility to Cocaine
Cocaine results in increased expression of SLC6A3 protein
Cocaine binds to SLC6A3 protein

PMID:8825631 PMID:9372557 PMID:9736005 PMID:10581411 PMID:11072100 More...

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

increases expression
multiple interactions
decreases response to substance
affects expression
increases response to substance
affects response to substance
decreases activity

ISO
EXP

Cocaine results in increased expression of SLC6A4 protein
Cocaine binds to and results in decreased activity of SLC6A4 protein; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Cocaine inhibits the reaction [SLC6A4 protein results in increased import of Biogenic Monoamines analog]; Cocaine inhibits the reaction [SLC6A4 protein results in increased import of Fluorescent Dyes]; Cocaine inhibits the reaction [SLC6A4 protein results in increased uptake of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium]
SLC6A4 results in decreased susceptibility to Cocaine
Cocaine affects the expression of SLC6A4 mRNA
SLC6A4 gene mutant form results in increased susceptibility to Cocaine
SLC6A4 mutant form affects the susceptibility to Cocaine
Cocaine results in decreased activity of SLC6A4 protein

PMID:11072100 PMID:11207425 PMID:11320258 PMID:16272152 PMID:18321529 More...

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier family 7 member 11

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier family 9 member A2

decreases expression

ISO

Cocaine results in decreased expression of SLC9A2 mRNA

NCBI chr 9:50,427,612...50,510,043
Ensembl chr 9:50,426,798...50,510,040

G

solute carrier organic anion transporter family, member 1a8

affects expression

EXP

Cocaine affects the expression of SLCO1A8 mRNA

NCBI chr 4:176,706,205...176,749,723
Ensembl chr 4:176,706,208...176,745,669

G

SLIT and NTRK-like family, member 1

increases expression

EXP

Cocaine results in increased expression of SLITRK1 mRNA

NCBI chr15:92,137,703...92,141,741
Ensembl chr15:92,135,994...92,142,105

G

STE20-like kinase

affects expression

EXP

Cocaine affects the expression of SLK mRNA

NCBI chr 1:256,415,013...256,470,942
Ensembl chr 1:256,415,013...256,467,829

G

SMAD family member 1

multiple interactions

EXP

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD1 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in decreased ubiquitination of SMAD1 protein modified form; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased phosphorylation of SMAD1 protein

NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957

G

SMAD family member 3

multiple interactions

EXP

Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 5

multiple interactions

EXP

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD5 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased phosphorylation of SMAD5 protein

NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,871,984...7,890,992

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

increases expression

EXP

Cocaine results in increased expression of SMARCA2 mRNA

NCBI chr 1:233,617,277...233,784,908
Ensembl chr 1:233,617,366...233,784,869

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

multiple interactions
increases expression

EXP

[Cocaine co-treated with Cocaine deficiency] promotes the reaction [RUNX2 protein binds to SMARCA4 promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to CTNNB1 promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to DBN1 promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to MEF2D promoter]; Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein]
Cocaine deficiency results in increased expression of SMARCA4 protein

PMID:27422367 PMID:30158054

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:28,443,810...28,535,070

G

SNF2 related chromatin remodeling ATPase 5

increases expression
multiple interactions

ISO

Cocaine results in increased expression of SMARCA5 mRNA
[SMARCA5 protein co-treated with BAZ1B protein] results in increased susceptibility to Cocaine

NCBI chr19:44,172,465...44,208,967
Ensembl chr19:44,175,733...44,208,957

G

smoothelin

affects expression

EXP

Cocaine affects the expression of SMTN mRNA

NCBI chr14:82,622,223...82,644,525
Ensembl chr14:82,621,375...82,644,514

G

SMAD specific E3 ubiquitin protein ligase 1

multiple interactions

EXP

[Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to RHOA protein]; [Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD1 protein modified form]; [Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD5 protein modified form]; [Cocaine co-treated with Cocaine deficiency] results in decreased expression of SMURF1 protein

NCBI chr12:14,748,717...14,840,273
Ensembl chr12:14,749,043...14,840,273

G

snail family transcriptional repressor 3

increases expression

EXP

Cocaine results in increased expression of SNAI3 mRNA

NCBI chr19:67,425,311...67,437,830
Ensembl chr19:67,425,157...67,434,268

G

synaptosome associated protein 91

affects expression

EXP

Cocaine affects the expression of SNAP91 mRNA

NCBI chr 8:96,618,039...96,732,763
Ensembl chr 8:96,618,041...96,732,507

G

small nuclear RNA activating complex, polypeptide 2

affects expression

EXP

Cocaine affects the expression of SNAPC2 mRNA

NCBI chr12:7,403,650...7,406,840
Ensembl chr12:7,403,469...7,406,840

G

synuclein alpha

increases expression
affects expression

ISO

Cocaine results in increased expression of SNCA mRNA; Cocaine results in increased expression of SNCA protein
Cocaine affects the expression of SNCA protein

PMID:12684441 PMID:16110277 PMID:18055133 PMID:19393250

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

synuclein, alpha interacting protein

increases expression

EXP

Cocaine results in increased expression of SNCAIP mRNA

NCBI chr18:48,402,164...48,542,246
Ensembl chr18:48,404,531...48,574,002

G

synuclein, beta

affects expression

EXP

Cocaine affects the expression of SNCB mRNA

NCBI chr17:9,851,825...9,860,143
Ensembl chr17:9,840,019...9,860,142

G

staphylococcal nuclease and tudor domain containing 1

increases expression

EXP

Cocaine results in increased expression of SND1 protein

NCBI chr 4:58,060,689...58,459,926
Ensembl chr 4:58,060,640...58,459,925

G

syntaphilin

affects expression

EXP

Cocaine affects the expression of SNPH mRNA

NCBI chr 3:160,558,929...160,603,636
Ensembl chr 3:160,560,097...160,599,728

G

small nuclear ribonucleoprotein U5 subunit 200

affects expression

EXP

Cocaine affects the expression of SNRNP200 mRNA

NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500

G

syntrophin, gamma 2

increases expression
decreases expression

EXP

Cocaine results in increased expression of SNTG2 mRNA
Cocaine results in decreased expression of SNTG2 mRNA

PMID:17898221 PMID:27899881

NCBI chr 6:52,529,481...52,730,972
Ensembl chr 6:52,529,481...52,730,972

G

sorting nexin 27

increases expression

EXP

Cocaine results in increased expression of SNX27 mRNA alternative form

NCBI chr 2:184,824,930...184,907,931
Ensembl chr 2:184,806,844...184,907,931

G

superoxide dismutase 1

decreases expression
multiple interactions
increases activity

ISO

Cocaine results in decreased expression of SOD1 mRNA
GPX1 affects the reaction [Cocaine results in increased activity of SOD1 protein]

PMID:12629581 PMID:30027653

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases activity
multiple interactions

ISO

Cocaine results in increased activity of SOD2 protein
GPX1 affects the reaction [Cocaine results in increased activity of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SON DNA and RNA binding protein

affects expression

EXP

Cocaine affects the expression of SON mRNA

NCBI chr11:44,336,818...44,409,127
Ensembl chr11:44,377,976...44,409,127

G

sortilin-related VPS10 domain containing receptor 3

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of SORCS3 mRNA

NCBI chr 1:257,040,442...257,675,259
Ensembl chr 1:257,040,473...257,675,259

G

sortilin related receptor 1

decreases expression

EXP

Cocaine results in decreased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446

G

SRY-box transcription factor 30

decreases expression

EXP

Cocaine results in decreased expression of SOX30 mRNA

NCBI chr10:30,918,707...30,948,415
Ensembl chr10:30,919,778...30,948,415

G

Sp1 transcription factor

affects expression

EXP

Cocaine affects the expression of SP1 mRNA; Cocaine affects the expression of SP1 protein

PMID:16179556 PMID:20187946

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

sperm acrosome associated 9

increases expression

EXP

Cocaine results in increased expression of SPACA9 mRNA

NCBI chr 3:32,417,350...32,426,776
Ensembl chr 3:32,417,350...32,426,934

G

sperm associated antigen 4

affects expression

EXP

Cocaine affects the expression of SPAG4 mRNA

NCBI chr 3:165,040,682...165,047,963
Ensembl chr 3:165,041,134...165,045,519

G

SPARC like 1

affects expression

EXP

Cocaine affects the expression of SPARCL1 mRNA

NCBI chr14:5,937,484...5,968,532
Ensembl chr14:5,914,535...5,969,120

G

spermatogenesis associated, serine-rich 2-like

increases expression

EXP

Cocaine results in increased expression of SPATS2L mRNA

NCBI chr 9:66,814,217...66,988,084
Ensembl chr 9:66,814,228...66,988,578

G

SPHK1 interactor, AKAP domain containing

multiple interactions

ISO

Cocaine promotes the reaction [BAZ1B protein binds to SPHKAP gene]

NCBI chr 9:91,957,497...92,105,834
Ensembl chr 9:91,957,497...92,105,625

G

sprouty-related, EVH1 domain containing 1

affects expression

EXP

Cocaine affects the expression of SPRED1 mRNA

NCBI chr 3:124,437,230...124,504,358
Ensembl chr 3:124,437,230...124,504,358

G

sprouty RTK signaling antagonist 4

increases expression

EXP

Cocaine results in increased expression of SPRY4 mRNA

NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,687,039...30,704,173

G

spectrin, alpha, non-erythrocytic 1

increases cleavage

EXP

Cocaine results in increased cleavage of SPTAN1 protein

NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:33,607,210...33,703,889

G

spectrin, beta, non-erythrocytic 1

decreases expression

ISO

Cocaine results in decreased expression of SPTBN1 mRNA

NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836

G

spectrin, beta, non-erythrocytic 2

affects expression

EXP

Cocaine affects the expression of SPTBN2 mRNA

NCBI chr 1:211,432,373...211,473,016
Ensembl chr 1:211,432,373...211,473,306

G

sequestosome 1

decreases expression

ISO

Cocaine results in decreased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

steroid receptor associated and regulated protein

increases expression

EXP

Cocaine results in increased expression of SRARP mRNA

NCBI chr 5:159,023,949...159,028,053
Ensembl chr 5:159,023,949...159,028,053

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases phosphorylation
decreases activity
affects expression

ISO
EXP

Cocaine results in increased phosphorylation of SRC protein
Cocaine results in decreased activity of SRC protein
Cocaine affects the expression of SRC mRNA

PMID:20187946 PMID:20354174 PMID:27506785

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

SRC kinase signaling inhibitor 1

multiple interactions
increases expression

ISO

PRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]
cocaine increases expression of Srcin1 mRNA in nucleus accumbens
Cocaine results in increased expression of SRCIN1 mRNA; Cocaine results in increased expression of SRCIN1 protein

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr10:82,999,295...83,066,359
Ensembl chr10:82,991,033...83,067,419

G

serine and arginine rich splicing factor 3

decreases expression

EXP

Cocaine results in decreased expression of SRSF3 mRNA

NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,093,565...7,103,516

G

small RNA binding exonuclease protection factor La

affects expression

EXP

Cocaine affects the expression of SSB mRNA

NCBI chr 3:75,024,385...75,034,016
Ensembl chr 3:75,024,474...75,034,031

G

signal sequence receptor subunit 4

decreases expression

ISO

Cocaine results in decreased expression of SSR4 mRNA

NCBI chr X:156,675,658...156,679,545
Ensembl chr X:156,675,566...156,679,543

G

somatostatin receptor 1

affects expression

EXP

Cocaine affects the expression of SSTR1 mRNA

NCBI chr 6:81,567,237...81,571,759
Ensembl chr 6:81,566,850...81,571,992

G

somatostatin receptor 2

affects expression
increases expression

EXP

Cocaine affects the expression of SSTR2 mRNA
Cocaine results in increased expression of SSTR2 mRNA

PMID:20187946 PMID:27899881

NCBI chr10:99,163,353...99,170,519
Ensembl chr10:99,162,740...99,183,863

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

increases expression

ISO

Cocaine results in increased expression of ST3GAL6 mRNA

NCBI chr11:55,530,120...55,590,950
Ensembl chr11:55,530,248...55,598,720

G

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

decreases expression

EXP

Cocaine results in decreased expression of ST6GALNAC4 mRNA

NCBI chr 3:36,269,834...36,282,971
Ensembl chr 3:36,269,878...36,282,971

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

increases expression

ISO

Cocaine deficiency results in increased expression of ST8SIA3 mRNA

NCBI chr18:60,024,555...60,031,050
Ensembl chr18:60,024,236...60,032,473

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

ISO

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

signal transducer and activator of transcription 5B

affects expression

EXP

Cocaine affects the expression of STAT5B mRNA

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990

G

STEAP4 metalloreductase

decreases expression

EXP

Cocaine results in decreased expression of STEAP4 mRNA

NCBI chr 4:27,032,096...27,054,769
Ensembl chr 4:27,009,584...27,067,105

G

serine/threonine kinase 40

affects expression

EXP

Cocaine affects the expression of STK40 mRNA

NCBI chr 5:143,660,438...143,702,336
Ensembl chr 5:143,665,090...143,702,335

G

striatin interacting protein 2

increases expression

ISO

Cocaine deficiency results in increased expression of STRIP2 mRNA

NCBI chr 4:59,503,478...59,545,745
Ensembl chr 4:59,503,481...59,545,739

G

syntaxin 1B

affects expression
increases expression

EXP

Cocaine affects the expression of STX1B mRNA
Cocaine results in increased expression of STX1B mRNA

PMID:16076954 PMID:20187946

NCBI chr 1:191,846,016...191,864,878
Ensembl chr 1:191,833,743...191,871,633

G

syntaxin binding protein 1

affects expression

EXP

Cocaine affects the expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058

G

sulfatase 1

decreases expression

EXP

Cocaine results in decreased expression of SULF1 mRNA

NCBI chr 5:11,145,950...11,308,622
Ensembl chr 5:11,145,950...11,308,643

G

SPT5 homolog, DSIF elongation factor subunit

affects expression

EXP

Cocaine affects the expression of SUPT5H mRNA

NCBI chr 1:92,714,276...92,745,489
Ensembl chr 1:92,714,281...92,744,445

G

SUV39H1 histone lysine methyltransferase

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of SUV39H1 mRNA]

NCBI chr X:17,093,059...17,105,942
Ensembl chr X:17,092,986...17,105,942

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of SUV39H1 mRNA]

NCBI chr X:146,828,818...146,831,485

G

syntabulin

decreases expression

EXP

Cocaine results in decreased expression of SYBU mRNA

NCBI chr 7:77,731,662...77,833,413
Ensembl chr 7:77,731,605...77,833,686

G

synapsin I

multiple interactions
affects expression
increases expression

ISO
EXP

SYN1 protein affects the reaction [Cocaine results in increased secretion of Dopamine]
ILK mutant form inhibits the reaction [Cocaine results in increased expression of SYN1 protein]
Cocaine affects the expression of SYN1 mRNA

PMID:16554471 PMID:19629758 PMID:20187946

NCBI chr X:3,725,745...3,780,940
Ensembl chr X:3,725,714...3,780,938

G

synapsin II

multiple interactions

ISO

SYN2 protein affects the reaction [Cocaine results in increased secretion of Dopamine]

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650

G

synapsin III

multiple interactions

ISO

SYN3 protein affects the reaction [Cocaine results in increased secretion of Dopamine]

NCBI chr 7:19,244,032...19,701,571
Ensembl chr 7:19,264,094...19,696,510

G

spectrin repeat containing nuclear envelope protein 1

increases expression
multiple interactions

ISO

Cocaine results in increased expression of SYNE1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYNE1 mRNA]

NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721

G

synaptopodin 2

decreases expression

EXP

Cocaine results in decreased expression of SYNPO2 mRNA

NCBI chr 2:213,901,685...214,055,844
Ensembl chr 2:213,900,868...214,055,844

G

synaptopodin 2-like

increases expression

EXP

Cocaine results in increased expression of SYNPO2L mRNA

NCBI chr15:3,681,224...3,690,673
Ensembl chr15:3,681,104...3,690,673

G

synaptophysin

increases expression

EXP

Cocaine results in increased expression of SYP mRNA

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

synaptotagmin 1

affects expression

EXP

Cocaine affects the expression of SYT1 mRNA

NCBI chr 7:45,699,649...46,244,460
Ensembl chr 7:45,702,228...46,244,213

G

synaptotagmin 10

increases expression

EXP

Cocaine results in increased expression of SYT10 mRNA

NCBI chr 7:122,737,301...122,800,462
Ensembl chr 7:122,648,419...122,800,462

G

synaptotagmin 11

increases expression

ISO
EXP

Cocaine results in increased expression of SYT11 mRNA

PMID:16076954 PMID:18000554

NCBI chr 2:176,503,845...176,530,354
Ensembl chr 2:176,503,845...176,529,775

G

synaptotagmin 13

affects response to substance

ISO

SYT13 gene SNP affects the susceptibility to Cocaine

NCBI chr 3:99,332,554...99,372,960
Ensembl chr 3:99,329,957...99,376,316

G

synaptotagmin 2

increases expression
multiple interactions

ISO

Cocaine results in increased expression of SYT2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYT2 mRNA]

NCBI chr13:48,639,634...48,749,814
Ensembl chr13:48,639,934...48,749,812

G

synaptotagmin 3

increases expression

EXP

Cocaine results in increased expression of SYT3 mRNA

NCBI chr 1:104,017,341...104,032,046
Ensembl chr 1:104,017,379...104,032,045

G

synaptotagmin 4

increases expression

EXP

Cocaine results in increased expression of SYT4 mRNA

NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815

G

synaptotagmin 5

affects expression

EXP

Cocaine affects the expression of SYT5 mRNA

NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:78,320,034...78,327,746

G

synaptotagmin 7

multiple interactions

ISO

[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of SYT7 protein; Cocaine promotes the reaction [DRD1 protein results in increased expression of SYT7 protein]; Cocaine promotes the reaction [DRD3 protein results in decreased expression of SYT7 protein]

NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:216,456,259...216,518,718

G

synaptotagmin 9

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of SYT9 mRNA

NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:170,687,606...170,881,375

G

tachykinin, precursor 1

affects expression
increases expression

EXP
ISO

Cocaine affects the expression of TAC1 mRNA
Cocaine results in increased expression of TAC1 mRNA
Cocaine deficiency results in increased expression of TAC1 mRNA

PMID:11072100 PMID:16395306 PMID:17898221 PMID:27126842

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

transforming, acidic coiled-coil containing protein 1

affects expression

EXP

Cocaine affects the expression of TACC1 mRNA

NCBI chr16:73,515,016...73,598,395
Ensembl chr16:73,514,889...73,598,394

G

tachykinin receptor 1

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA]

NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492

G

tachykinin receptor 3

increases response to substance

ISO

TACR3 SNP results in increased susceptibility to Cocaine

NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:225,940,444...226,037,756

G

transgelin 3

decreases expression

ISO

Cocaine results in decreased expression of TAGLN3 mRNA

NCBI chr11:68,562,482...68,576,058
Ensembl chr11:68,562,338...68,576,051

G

transaldolase 1

increases expression

EXP

Cocaine results in increased expression of TALDO1 protein

NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:205,923,165...205,933,535

G

Tarbp2 subunit of RISC loading complex

affects expression

EXP

Cocaine affects the expression of TARBP2 mRNA

NCBI chr 7:135,527,710...135,532,826
Ensembl chr 7:135,527,589...135,533,323

G

threonyl-tRNA synthetase 1

affects expression

EXP

Cocaine affects the expression of TARS1 mRNA

NCBI chr 2:62,095,978...62,114,802
Ensembl chr 2:62,087,763...62,114,802

G

Tax1 binding protein 3

affects expression

EXP

Cocaine affects the expression of TAX1BP3 mRNA

NCBI chr10:58,294,357...58,298,875
Ensembl chr10:58,294,073...58,298,875

G

TBC1 domain family, member 14

affects expression

EXP

Cocaine affects the expression of TBC1D14 mRNA

NCBI chr14:78,397,345...78,496,863
Ensembl chr14:78,397,355...78,496,865

G

TBC1 domain family, member 20

affects expression

EXP

Cocaine affects the expression of TBC1D20 mRNA

NCBI chr 3:161,228,699...161,247,319
Ensembl chr 3:161,228,785...161,247,316

G

TBC1 domain family, member 24

increases expression

EXP

Cocaine results in increased expression of TBC1D24 protein

NCBI chr10:13,711,930...13,740,902
Ensembl chr10:13,714,833...13,740,473

G

transcription factor 19

decreases expression

EXP

Cocaine results in decreased expression of TCF19 mRNA

NCBI chr20:3,223,464...3,227,569
Ensembl chr20:3,223,324...3,230,060

G

transcription factor 4

affects expression

EXP

Cocaine affects the expression of TCF4 mRNA

NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401

G

trichohyalin

decreases expression

EXP

Cocaine results in decreased expression of TCHH mRNA

NCBI chr 2:181,787,109...181,795,463
Ensembl chr 2:181,787,109...181,795,463

G

TEA domain transcription factor 1

affects expression

EXP

Cocaine affects the expression of TEAD1 mRNA

NCBI chr 1:176,227,175...176,445,122
Ensembl chr 1:176,227,175...176,438,198

G

teneurin transmembrane protein 2

affects expression
decreases expression

EXP

Cocaine affects the expression of TENM2 mRNA
Cocaine results in decreased expression of TENM2 mRNA

PMID:17898221 PMID:20187946

NCBI chr10:20,984,710...22,121,001
Ensembl chr10:20,985,902...22,447,611

G

teneurin transmembrane protein 3

affects response to substance

ISO

TENM3 gene SNP affects the susceptibility to Cocaine

NCBI chr16:47,984,732...50,711,352
Ensembl chr16:49,829,750...50,711,352

G

teneurin transmembrane protein 4

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in increased expression of TENM4 mRNA

NCBI chr 1:157,699,611...160,674,549
Ensembl chr 1:159,974,017...160,674,549

G

testis associated actin remodelling kinase 1

affects expression

EXP

Cocaine affects the expression of TESK1 mRNA

NCBI chr 5:62,487,763...62,493,492
Ensembl chr 5:62,487,763...62,493,492

G

transferrin

decreases expression

ISO
EXP

Cocaine results in decreased expression of TF mRNA

PMID:16076954 PMID:18357522

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

transcription factor AP-4

increases expression

ISO

Cocaine results in increased expression of TFAP4 mRNA

NCBI chr10:11,507,242...11,525,794
Ensembl chr10:11,485,565...11,525,794

G

transcription factor Dp-2

increases expression

EXP

Cocaine results in increased expression of TFDP2 mRNA

NCBI chr 8:105,640,018...105,781,026
Ensembl chr 8:105,640,033...105,781,001

G

tuftelin interacting protein 11

affects expression

EXP

Cocaine affects the expression of TFIP11 mRNA

NCBI chr12:49,960,025...49,972,257
Ensembl chr12:49,960,026...49,972,257

G

transferrin receptor

increases expression

ISO

Cocaine results in increased expression of TFRC mRNA

PMID:15009677 PMID:16710320

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transforming growth factor, beta 2

increases expression

EXP

Cocaine results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta receptor 1

increases expression
multiple interactions

ISO

Cocaine results in increased expression of TGFBR1 mRNA
EHMT2 inhibits the reaction [Cocaine results in increased expression of TGFBR1 mRNA]

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

tyrosine hydroxylase

decreases phosphorylation
multiple interactions
affects expression
increases expression
decreases expression

ISO
EXP

Cocaine results in decreased phosphorylation of TH protein
resveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein]
Cocaine affects the expression of TH protein
Cocaine results in increased expression of TH protein
Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]
Cocaine results in decreased expression of TH protein

PMID:11391778 PMID:12787079 PMID:18992788 PMID:20729865 PMID:23499958

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

thimet oligopeptidase 1

affects expression

EXP

Cocaine affects the expression of THOP1 mRNA

NCBI chr 7:9,283,617...9,295,957
Ensembl chr 7:9,283,617...9,295,957

G

thyroid hormone receptor alpha

multiple interactions

ISO

[Cocaine co-treated with FOS protein mutant form] results in decreased expression of THRA mRNA

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

TIAM Rac1 associated GEF 2

decreases expression

EXP

Cocaine results in decreased expression of TIAM2 mRNA

NCBI chr 1:46,323,450...46,524,769
Ensembl chr 1:46,323,456...46,524,769

G

translocase of inner mitochondrial membrane 10B

affects expression

EXP

Cocaine affects the expression of TIM9B mRNA

NCBI chr 1:169,392,355...169,395,201
Ensembl chr 1:169,392,177...169,395,205

G

TOR signaling pathway regulator

increases expression

ISO

Cocaine results in increased expression of TIPRL mRNA

NCBI chr13:80,060,193...80,085,040
Ensembl chr13:80,039,673...80,085,040

G

tight junction protein 2

affects expression

EXP

Cocaine affects the expression of TJP2 mRNA

NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750

G

thymidine kinase 1

decreases expression

EXP

Cocaine results in decreased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228

G

transketolase

affects expression

ISO

Cocaine affects the expression of TKT protein

NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,729,991...5,756,431

G

transmembrane p24 trafficking protein 5

increases expression

EXP

Cocaine results in increased expression of TMED5 mRNA

NCBI chr14:1,752,857...1,763,990
Ensembl chr14:1,752,745...1,773,389

G

transmembrane p24 trafficking protein 9

affects expression

EXP

Cocaine affects the expression of TMED9 mRNA

NCBI chr17:9,034,797...9,039,311
Ensembl chr17:9,034,823...9,039,319

G

transmembrane protein 132A

affects expression

EXP

Cocaine affects the expression of GBP mRNA

NCBI chr 1:216,931,962...216,943,644
Ensembl chr 1:216,931,962...216,943,644

G

transmembrane protein 14C

increases expression

EXP

Cocaine results in increased expression of TMEM14C protein

NCBI chr17:23,939,501...23,945,622
Ensembl chr17:23,939,509...23,959,055

G

transmembrane protein 184B

affects expression

EXP

Cocaine affects the expression of TMEM184B mRNA

NCBI chr 7:112,805,512...112,848,398
Ensembl chr 7:112,805,512...112,848,351

G

transmembrane protein 200B

decreases expression

EXP

Cocaine results in decreased expression of TMEM200B mRNA

NCBI chr 5:149,391,865...149,394,621
Ensembl chr 5:149,387,441...149,409,282

G

thymopoietin

increases expression

EXP

Cocaine results in increased expression of TMPO mRNA

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

tumor necrosis factor

multiple interactions
affects response to substance
increases expression
decreases expression
increases secretion

ISO
EXP

[Cocaine co-treated with Heroin] results in increased expression of TNF protein
TNF protein affects the susceptibility to Cocaine
Cocaine results in increased expression of TNF protein
Cocaine results in increased expression of TNF mRNA; Cocaine results in increased expression of TNF protein
Cocaine results in decreased expression of TNF protein
[IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF mRNA; [IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF protein; Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]; Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; TNF protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]; TNF protein affects the reaction [IL6 protein affects the susceptibility to Cocaine]
Cocaine results in increased secretion of TNF protein

PMID:10065903 PMID:10864098 PMID:11368239 PMID:11856816 PMID:16766138 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

affects expression

ISO

Cocaine affects the expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 14

increases expression

ISO

Cocaine results in increased expression of TNFRSF14 mRNA

NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:170,768,416...170,776,046

G

TNF receptor superfamily member 18

affects expression

ISO

Cocaine affects the expression of TNFRSF18 mRNA

NCBI chr 5:171,901,734...171,904,578
Ensembl chr 5:171,901,717...171,904,576

G

TNF receptor superfamily member 1A

affects expression

ISO

Cocaine affects the expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 1B

affects expression

ISO

Cocaine affects the expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

TNF receptor superfamily member 25

affects expression
multiple interactions
increases expression

ISO

Cocaine affects the expression of TNFRSF25 mRNA
EHMT2 inhibits the reaction [Cocaine results in increased expression of TNFRSF25 mRNA]

PMID:15681117 PMID:20056891

NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052

G

TNF superfamily member 10

decreases expression

EXP

Cocaine results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

troponin I3, cardiac type

increases secretion

ISO

Cocaine results in increased secretion of TNNI3 protein

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

transducer of ErbB-2.1

decreases expression

ISO

Cocaine results in decreased expression of TOB1 mRNA

NCBI chr10:79,659,993...79,662,031
Ensembl chr10:79,656,433...79,666,601

G

transducer of ERBB2, 2

affects expression

EXP

Cocaine affects the expression of TOB2 mRNA

NCBI chr 7:115,242,843...115,251,563
Ensembl chr 7:115,239,895...115,258,155

G

translocase of outer mitochondrial membrane 20

increases expression

ISO

Cocaine results in increased expression of TOMM20 protein

NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510

G

tumor protein p53

affects expression

ISO

Cocaine affects the expression of TRP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible nuclear protein 2

decreases expression

ISO

Cocaine results in decreased expression of TP53INP2 mRNA

NCBI chr 3:164,341,618...164,350,270
Ensembl chr 3:164,343,205...164,350,225

G

tropomyosin 3

affects expression

EXP

Cocaine affects the expression of TPM3 mRNA

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

tryptase gamma 1

affects expression

EXP

Cocaine affects the expression of TPSG1 mRNA

NCBI chr10:14,889,838...14,895,605
Ensembl chr10:14,890,734...14,894,786

G

Tnf receptor-associated factor 2

affects expression

ISO

Cocaine affects the expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

tribbles pseudokinase 1

affects expression

EXP

Cocaine affects the expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

tripartite motif-containing 28

affects expression

EXP

Cocaine affects the expression of TRIM28 mRNA

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tripartite motif-containing 3

affects expression

EXP

Cocaine affects the expression of TRIM3 mRNA

NCBI chr 1:169,362,751...169,385,430
Ensembl chr 1:169,356,738...169,385,430

G

tripartite motif containing 72

decreases expression

EXP

Cocaine results in decreased expression of TRIM72 mRNA

NCBI chr 1:192,044,220...192,052,080
Ensembl chr 1:192,044,179...192,052,073

G

tRNA methyltransferase 10C, mitochondrial RNase P subunit

affects expression

EXP

Cocaine affects the expression of TRMT10C mRNA

NCBI chr11:58,053,455...58,058,533
Ensembl chr11:58,033,201...58,059,062

G

tRNA methyltransferase 6 non-catalytic subunit

decreases expression

EXP

Cocaine results in decreased expression of TRMT6 mRNA

NCBI chr 3:140,527,785...140,539,520
Ensembl chr 3:140,527,788...140,539,509

G

transient receptor potential cation channel, subfamily C, member 4 associated protein

affects expression

EXP

Cocaine affects the expression of TRPC4AP mRNA

NCBI chr 3:164,582,146...164,653,123
Ensembl chr 3:164,582,146...164,653,123

G

TSPO associated protein 1

multiple interactions
increases expression

ISO

FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of TSPOAP1 mRNA]

NCBI chr10:73,053,414...73,083,640
Ensembl chr10:73,058,354...73,083,640

G

TSPY-like 1

affects expression

EXP

Cocaine affects the expression of TSPYL1 mRNA

NCBI chr20:39,637,035...39,639,594
Ensembl chr20:39,635,135...39,695,333

G

testis-specific serine kinase 2

affects expression

EXP

Cocaine affects the expression of TSSK2 mRNA

NCBI chr11:96,590,864...96,592,219

G

tetratricopeptide repeat domain 7B

decreases expression

EXP

Cocaine results in decreased expression of TTC7B mRNA

NCBI chr 6:125,317,011...125,528,843
Ensembl chr 6:125,316,789...125,528,779

G

tubulin, alpha 3B

decreases expression

ISO

Cocaine results in decreased expression of TUBA3D mRNA

NCBI chr 4:180,319,600...180,325,149
Ensembl chr 4:180,319,600...180,325,147

G

tubulin, alpha 4A

decreases expression

ISO

Cocaine results in decreased expression of TUBA4A mRNA

NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584

G

tubulin, alpha 8

decreases expression

ISO

Cocaine results in decreased expression of TUBA8 mRNA

NCBI chr 4:156,110,562...156,129,065
Ensembl chr 4:156,111,964...156,141,436

G

terminal uridylyl transferase 4

decreases expression

EXP

Cocaine results in decreased expression of TUT4 mRNA

NCBI chr 5:128,354,975...128,535,288
Ensembl chr 5:128,431,719...128,535,656

G

thioredoxin 2

affects expression

EXP

Cocaine affects the expression of TXN2 mRNA

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin domain containing 15

affects expression

EXP

Cocaine affects the expression of TXNDC15 mRNA

NCBI chr17:8,903,248...8,915,714
Ensembl chr17:8,903,252...8,916,079

G

tyrosine kinase 2

affects response to substance

ISO

TYK2 gene SNP affects the susceptibility to Cocaine

NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:27,916,496...27,943,278

G

tyrosinase-related protein 1

increases expression

EXP

Cocaine results in increased expression of TYRP1 mRNA

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

ubiquitin-conjugating enzyme E2I

increases expression

ISO

Cocaine results in increased expression of UBE2I mRNA

NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866

G

ubiquitin-conjugating enzyme E2M

decreases expression

ISO

Cocaine results in decreased expression of UBE2M mRNA

NCBI chr 1:82,734,761...82,738,298
Ensembl chr 1:82,732,231...82,738,613

G

ubiquitin protein ligase E3A

decreases expression

EXP

Cocaine results in decreased expression of UBE3A mRNA

NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097

G

ubiquitin protein ligase E3 component n-recognin 4

affects expression

EXP

Cocaine affects the expression of UBR4 mRNA

NCBI chr 5:156,919,029...157,027,127
Ensembl chr 5:156,919,085...157,027,127

G

upstream binding transcription factor

affects expression

EXP

Cocaine affects the expression of UBTF mRNA

NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,758,346...87,773,088

G

ubiquitin C-terminal hydrolase L1

decreases expression

ISO

Cocaine results in decreased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

ubiquitin C-terminal hydrolase L3

affects expression

EXP

Cocaine affects the expression of UCHL3 mRNA

NCBI chr15:84,888,847...84,942,095
Ensembl chr15:84,899,806...84,942,095
Ensembl chr 3:84,899,806...84,942,095

G

UDP-glucose ceramide glucosyltransferase

increases expression

ISO

Cocaine results in increased expression of UGCG mRNA

PMID:15009677 PMID:16710320

NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

affects expression

EXP

Cocaine affects the expression of UGT1A8 mRNA

NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

ubiquinol-cytochrome c reductase hinge protein

affects expression

EXP

Cocaine affects the expression of UQCRH mRNA

NCBI chr 5:134,782,687...134,790,882
Ensembl chr 5:134,782,255...134,790,926

G

USO1 vesicle transport factor

increases expression

EXP

Cocaine results in increased expression of USO1 protein

NCBI chr14:16,150,921...16,216,389
Ensembl chr14:16,150,923...16,216,389

G

ubiquitin specific peptidase 46

increases expression
increases expression

ISO

Cocaine results in increased expression of USP46 mRNA
cocaine increases expression of Usp46 mRNA in nucleus accumbens

CTD
RGD

PMID:27506785 PMID:27506785

NCBI chr14:34,504,074...34,573,318
Ensembl chr14:34,504,118...34,573,307

G

ubiquitin specific peptidase 7

increases expression

EXP

Cocaine results in increased expression of USP7 mRNA

NCBI chr10:7,335,508...7,432,018
Ensembl chr10:7,367,604...7,432,013

G

ubiquitin specific peptidase 9, X-linked

increases expression
multiple interactions

ISO

Cocaine results in increased expression of USP9X mRNA
EHMT2 inhibits the reaction [Cocaine results in increased expression of USP9X mRNA]

NCBI chr X:12,261,633...12,399,780
Ensembl chr X:12,261,633...12,369,491

G

integral membrane transport protein UST5r

increases expression

EXP

Cocaine results in increased expression of UST5R mRNA

NCBI chr 1:214,640,172...214,716,024
Ensembl chr 1:214,640,172...214,715,861

G

UDP-glucuronate decarboxylase 1

affects expression

EXP

Cocaine affects the expression of UXS1 mRNA

NCBI chr 9:740,929...818,310
Ensembl chr 9:740,724...818,319

G

vesicle-associated membrane protein 7

affects expression

EXP

Cocaine affects the expression of SYBL1 mRNA

NCBI chr12:21,842,206...21,958,556
Ensembl chr12:21,842,228...21,958,552

G

VAMP associated protein B and C

decreases expression

EXP

Cocaine results in decreased expression of VAPB mRNA

NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619

G

vesicle amine transport 1

affects expression

EXP

Cocaine affects the expression of VAT1 mRNA

NCBI chr10:86,889,793...86,897,411
Ensembl chr10:86,889,793...86,897,411

G

vascular endothelial growth factor A

affects expression

EXP

Cocaine affects the expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

von Ebners gland protein 2

decreases expression

EXP

Cocaine results in decreased expression of VEGP2 mRNA

NCBI chr 3:29,914,540...29,940,231

G

VGF nerve growth factor inducible

increases expression

EXP

Cocaine results in increased expression of VGF mRNA

NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703

G

vitamin K epoxide reductase complex, subunit 1-like 1

affects expression

EXP

Cocaine affects the expression of VKORC1L1 mRNA

NCBI chr12:32,354,078...32,404,327

G

vomeronasal 1 receptor 90

affects expression

EXP

Cocaine affects the expression of VOM1R90 mRNA

NCBI chr 4:123,696,273...123,705,276
Ensembl chr 4:123,696,273...123,705,287

G

VPS26 retromer complex component B

increases expression

EXP

Cocaine results in increased expression of VPS26B protein

NCBI chr 8:33,675,025...33,696,132
Ensembl chr 8:33,675,025...33,696,132

G

vacuolar protein sorting 4 homolog A

affects expression

EXP

Cocaine affects the expression of VPS4A mRNA

NCBI chr19:51,838,411...51,858,639
Ensembl chr19:51,833,914...51,872,423

G

vesicle transport through interaction with t-SNAREs 1A

affects expression

EXP

Cocaine affects the expression of VTI1A mRNA

NCBI chr 1:264,361,538...264,667,171
Ensembl chr 1:264,361,522...264,668,727

G

von Willebrand factor

increases expression

ISO

Cocaine results in increased expression of VWF protein

PMID:10493323 PMID:11988210

NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757

G

tryptophanyl-tRNA synthetase 1

affects expression

EXP

Cocaine affects the expression of WARS1 mRNA

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

whirlin

affects expression

EXP

Cocaine affects the expression of WHRN mRNA

NCBI chr 5:81,843,820...81,933,400
Ensembl chr 5:81,843,820...81,927,381

G

WNK lysine deficient protein kinase 3

multiple interactions
increases expression

ISO

EHMT2 inhibits the reaction [Cocaine results in increased expression of WNK3 mRNA]

NCBI chr X:23,599,278...23,742,290
Ensembl chr X:23,599,305...23,742,290

G

Wnt family member 2

decreases expression

EXP

Cocaine results in decreased expression of WNT2 mRNA

NCBI chr 4:47,294,300...47,340,284
Ensembl chr 4:47,294,300...47,421,976

G

Wnt family member 5A

multiple interactions

ISO

HDAC5 affects the reaction [Cocaine affects the expression of WNT5A mRNA]

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860

G

Wnt family member 9B

decreases expression

EXP

Cocaine results in decreased expression of WNT9B mRNA

NCBI chr10:89,135,362...89,157,065
Ensembl chr10:89,135,363...89,157,065

G

X-box binding protein 1

increases expression

EXP

Cocaine results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

xanthine dehydrogenase

multiple interactions
increases activity

EXP

acetovanillone inhibits the reaction [Cocaine results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

XK related 8

affects expression

EXP

Cocaine affects the expression of XKR8 mRNA

NCBI chr 5:150,222,058...150,229,184
Ensembl chr 5:150,222,061...150,228,564

G

tyrosyl-tRNA synthetase 2

affects expression

EXP

Cocaine affects the expression of YARS2 mRNA

NCBI chr11:98,136,530...98,142,320
Ensembl chr11:98,115,386...98,142,668

G

Y box binding protein 1

affects expression

EXP

Cocaine affects the expression of YBX1 mRNA

NCBI chr 5:138,167,444...138,188,155
Ensembl chr 5:138,167,444...138,184,188

G

Y box binding protein 3

affects expression

EXP

Cocaine affects the expression of YBX3 mRNA

NCBI chr 4:166,861,180...166,884,532
Ensembl chr 4:166,861,181...166,884,691

G

Yip1 interacting factor homolog A, membrane trafficking protein

affects expression

EXP

Cocaine affects the expression of YIF1A mRNA

NCBI chr 1:211,823,921...211,828,437
Ensembl chr 1:211,824,273...211,828,802

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

increases expression

ISO

Cocaine results in increased expression of YWHAE mRNA

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

affects expression
decreases expression

EXP
ISO

Cocaine affects the expression of YWHAH mRNA
Cocaine results in decreased expression of YWHAH mRNA

PMID:12629581 PMID:20187946

NCBI chr14:81,920,819...81,930,202
Ensembl chr14:81,920,590...81,947,930

G

zinc finger and BTB domain containing 16

affects expression

EXP

Cocaine affects the expression of ZBTB16 mRNA

NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507

G

zinc finger and BTB domain containing 18

affects expression

EXP

Cocaine affects the expression of ZBTB18 mRNA

NCBI chr13:91,971,602...91,980,058
Ensembl chr13:91,969,755...91,980,386

G

zinc finger and BTB domain containing 22

affects expression

EXP

Cocaine affects the expression of ZBTB22 mRNA

NCBI chr20:4,968,215...4,971,734
Ensembl chr20:4,967,718...4,970,699

G

zinc finger DHHC-type palmitoyltransferase 8

affects expression

EXP

Cocaine affects the expression of ZDHHC8 mRNA

NCBI chr11:96,259,383...96,273,588
Ensembl chr11:96,259,449...96,284,003

G

zinc finger homeobox 2

affects expression

EXP

Cocaine affects the expression of ZFHX2 mRNA

NCBI chr15:32,501,755...32,541,720
Ensembl chr15:32,503,115...32,535,085

G

zinc finger protein 148

affects expression

EXP

Cocaine affects the expression of ZNF148 mRNA

NCBI chr11:80,780,865...80,890,877
Ensembl chr11:80,786,087...80,890,877

G

zinc finger protein 207

increases expression

EXP

Cocaine results in increased expression of ZFP207 mRNA

NCBI chr10:65,883,630...65,895,895
Ensembl chr10:65,883,599...65,895,895

G

zinc finger protein 394

affects expression

EXP

Cocaine affects the expression of ZNF394 mRNA

NCBI chr12:14,522,820...14,530,998

G

zinc finger protein 483

increases expression

EXP

Cocaine results in increased expression of ZNF483 mRNA

NCBI chr 5:78,558,213...78,575,559
Ensembl chr 5:78,558,304...78,575,552

G

zinc finger protein 93

increases expression

EXP

Cocaine results in increased expression of ZFP93 mRNA

NCBI chr 3:178,052,001...178,073,023
Ensembl chr 3:178,052,001...178,073,023

G

zinc finger protein, multitype 1

increases expression
multiple interactions

ISO

Cocaine results in increased expression of ZFPM1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ZFPM1 mRNA]

NCBI chr19:67,242,922...67,299,149
Ensembl chr19:67,179,751...67,299,149

G

zinc finger protein, multitype 2

decreases expression

EXP

Cocaine results in decreased expression of ZFPM2 mRNA

NCBI chr 7:73,563,732...74,001,041
Ensembl chr 7:73,563,732...74,001,041

G

zinc fingers and homeoboxes 3

affects expression

EXP

Cocaine affects the expression of ZHX3 mRNA

NCBI chr 3:169,837,497...169,968,371
Ensembl chr 3:169,837,516...169,935,530

dihydroergotamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Dihydroergotamine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Dihydroergotamine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases activity

ISO
EXP

Dihydroergotamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Dihydroergotamine results in decreased activity of CYP1A1 protein
Dihydroergotamine results in increased activity of CYP1A1 protein

PMID:18420780 PMID:18493746 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

Dihydroergotamine results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity

ISO

Dihydroergotamine results in decreased activity of CYP2A4 protein

NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity

ISO

Dihydroergotamine results in decreased activity of CYP2B10 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

Dihydroergotamine results in decreased activity of CYP2C29 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

ISO

Dihydroergotamine results in decreased activity of CYP2D6 protein
Dihydroergotamine results in decreased activity of CYP2D22 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

Dihydroergotamine results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

5-hydroxytryptamine (serotonin) receptor 5B

multiple interactions

EXP

dihydroergotamine binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b]

RGD

NCBI chr13:35,239,662...35,252,586
Ensembl chr13:35,239,662...35,252,586

G

interleukin 24

increases expression

ISO

Dihydroergotamine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

Dihydroergotamine results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin-related polypeptide alpha

multiple interactions
decreases expression

EXP

GR 127935 inhibits the reaction [eletriptan results in decreased expression of CALCA mRNA]; isamoltane inhibits the reaction [eletriptan results in decreased expression of CALCA mRNA]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

5-hydroxytryptamine receptor 1B

multiple interactions

EXP

eletriptan binds to and results in increased activity of HTR1B protein

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583

G

5-hydroxytryptamine receptor 1D

multiple interactions

EXP

eletriptan binds to and results in increased activity of HTR1D protein

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

eletriptan results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin-related polypeptide alpha

multiple interactions

EXP

Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

caspase 3

increases activity

ISO

Ergotamine results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutathione S-transferase pi 1

multiple interactions

ISO

Ergotamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

5-hydroxytryptamine receptor 2B

multiple interactions

ISO

Ergotamine binds to and results in increased activity of HTR2B protein

NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:94,190,109...94,204,087

Ile(5)-angiotensin II

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

affects abundance

ISO

[ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

EXP

Spironolactone inhibits the reaction [Angiotensin II results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of ACTA2 protein]
Angiotensin II results in increased expression of ACTA2 mRNA; Angiotensin II results in increased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

angiotensinogen

multiple interactions

ISO

[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

increases expression

EXP

Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

C-C motif chemokine ligand 2

increases expression
multiple interactions

ISO

Angiotensin II results in increased expression of CCL2 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

collagen type I alpha 1 chain

increases expression
multiple interactions

ISO
EXP

Angiotensin II results in increased expression of COL1A1 mRNA
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]

PMID:33746155 PMID:39218321

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

increases expression
multiple interactions

ISO
EXP

Angiotensin II results in increased expression of COL3A1 mRNA
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of COL3A1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of COL3A1 mRNA]

PMID:33746155 PMID:39218321

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

carnitine palmitoyltransferase 1A

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of CPT1A mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

endothelin receptor type B

increases expression

EXP

Angiotensin II results in increased expression of EDNRB protein

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

estrogen related receptor, alpha

multiple interactions
decreases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

fission, mitochondrial 1

increases expression
multiple interactions

ISO

Angiotensin II results in increased expression of FIS1 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

heme oxygenase 1

multiple interactions
decreases expression

EXP

Spironolactone inhibits the reaction [Angiotensin II results in decreased expression of HMOX1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in decreased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 1 beta

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases expression
multiple interactions

ISO

Angiotensin II results in increased expression of IL6 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein]

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

matrix metallopeptidase 2

multiple interactions
increases expression

EXP

Spironolactone inhibits the reaction [Angiotensin II results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of MMP2 mRNA]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

myosin heavy chain 6

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of MYH6 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form]

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

ISO
EXP

NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]
Spironolactone inhibits the reaction [Angiotensin II results in decreased expression of NFE2L2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in decreased expression of NFE2L2 mRNA]

PMID:33746155 PMID:39218321

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NADPH oxidase 4

increases expression
multiple interactions

ISO

Angiotensin II results in increased expression of NOX4 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]

PMID:33746155 PMID:38230784

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

natriuretic peptide A

multiple interactions
increases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

multiple interactions
increases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA]

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

nuclear receptor subfamily 1, group I, member 2

affects response to substance

ISO

NR1I2 protein affects the susceptibility to Angiotensin II

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of PDHA1 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:38,509,084...38,522,536

G

phosphofructokinase, muscle

multiple interactions
increases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]]

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

periostin

increases expression

ISO

Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP

PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

PPARG coactivator 1 alpha

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of PPARGC1A protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

PPARG coactivator 1 beta

multiple interactions
decreases expression

EXP

celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein]

NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466

G

transcription factor A, mitochondrial

decreases expression
multiple interactions

EXP

Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transforming growth factor, beta 1

increases expression
multiple interactions

EXP

Angiotensin II results in increased expression of TGFB1 mRNA
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of TGFB1 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
increases expression

ISO

naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

increases expression

ISO

Leukotriene B4 results in increased expression of ACTA2 protein
Leukotriene B4 results in increased expression of ACTA2 mRNA

PMID:27697457 PMID:30818366

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

aryl hydrocarbon receptor

multiple interactions

EXP

AHR mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased chemical synthesis of Leukotriene B4]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

AKT serine/threonine kinase 1

multiple interactions

ISO

Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arachidonate 5-lipoxygenase

increases secretion
increases chemical synthesis
multiple interactions

ISO
EXP

ALOX5 protein results in increased secretion of Leukotriene B4
ALOX5 protein results in increased chemical synthesis of Leukotriene B4
[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [RS 43179 results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Tamoxifen results in increased expression of ALOX5 protein] which results in increased abundance of Leukotriene B4; [tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]; ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; quercetin 3'-sulfate inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Quercetin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]
[[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B4; [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [CXCL8 protein results in increased abundance of Leukotriene B4]; tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]

PMID:1781415 PMID:2849922 PMID:8058773 PMID:9223651 PMID:9445378 More...

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

ISO

ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions

ISO

Leukotriene B4 results in decreased expression of BAX mRNA; Leukotriene B4 results in decreased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

complement C5

multiple interactions
increases abundance

ISO

MK 0591 inhibits the reaction [C5 protein results in increased abundance of Leukotriene B4]

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

C-C motif chemokine ligand 12

increases abundance
multiple interactions

ISO

CCL12 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4]

NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,567,876...67,569,426

G

C-C motif chemokine ligand 2

increases expression
multiple interactions
increases abundance

ISO

Leukotriene B4 results in increased expression of CCL2 protein
zileuton inhibits the reaction [CCL2 protein results in increased abundance of Leukotriene B4]

PMID:12388339 PMID:19880577

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 5

multiple interactions

EXP

[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4; Dexamethasone inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

collagen type I alpha 1 chain

increases expression

ISO

Leukotriene B4 results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

colony stimulating factor 2

increases secretion

ISO

Leukotriene B4 results in increased secretion of CSF2 protein

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

C-X-C motif chemokine ligand 3

increases abundance
multiple interactions

ISO

CXCL1 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [CXCL1 protein results in increased abundance of Leukotriene B4]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cysteinyl leukotriene receptor 1

multiple interactions

ISO

[LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4

NCBI chr X:75,734,281...75,762,873
Ensembl chr X:75,734,270...75,763,050

G

fibroblast growth factor 2

increases expression

ISO

Leukotriene B4 results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

heme oxygenase 1

multiple interactions

ISO

Leukotriene B4 inhibits the reaction [Zymosan results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
decreases expression
decreases activity

ISO

[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]
Leukotriene B4 results in decreased expression of HSD11B2 mRNA
Leukotriene B4 results in decreased activity of HSD11B2 protein

PMID:10377029 PMID:18032417

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

interferon gamma

multiple interactions

ISO

[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

ISO

Leukotriene B4 promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12B

multiple interactions

ISO

Leukotriene B4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 13

increases abundance
multiple interactions

EXP

IL13 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 1 beta

multiple interactions
increases abundance

ISO

resveratrol inhibits the reaction [IL1B protein results in increased abundance of Leukotriene B4]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

multiple interactions

ISO

IL4 protein inhibits the reaction [Calcimycin results in increased metabolism of Leukotriene B4]; IL4 protein inhibits the reaction [Zymosan affects the metabolism of Leukotriene B4]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

integrin subunit alpha M

multiple interactions
increases expression

ISO

Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]; LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]
LTB4 increases expression of ITGAM protein on neutrophils and monocytes

CTD
RGD

PMID:7473568 PMID:18064325

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit beta 2

increases expression
multiple interactions

EXP
ISO

Leukotriene B4 results in increased expression of ITGB2 protein
Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]; LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]

PMID:7473568 PMID:14716214

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

leukotriene A4 hydrolase

multiple interactions
increases chemical synthesis

ISO

1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; cyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; Oxygen inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; propanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]

PMID:2827578 PMID:17371808

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641

G

leukotriene B4 receptor

multiple interactions
affects response to substance
affects binding

ISO

[SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4; Leukotriene B4 binds to and affects the activity of LTB4R1 protein
Leukotriene B4 binds to and results in increased activity of LTB4R protein; LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]
LTB4R1 protein affects the susceptibility to Leukotriene B4
Leukotriene B4 analog binds to LTB4R1 protein

PMID:7473568 PMID:8014878 PMID:10934232 PMID:11006272

NCBI chr15:33,233,120...33,235,636
Ensembl chr15:33,232,820...33,235,637

G

leukotriene B4 receptor 2

affects binding

ISO

Leukotriene B4 binds to LTB4R2 protein

NCBI chr15:33,228,634...33,230,453
Ensembl chr15:33,228,634...33,230,453

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

Leukotriene B4 results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

Leukotriene B4 results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MCL1 apoptosis regulator, BCL2 family member

increases expression
multiple interactions

ISO

Leukotriene B4 results in increased expression of MCL1 mRNA; Leukotriene B4 results in increased expression of MCL1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

microsomal glutathione S-transferase 1

decreases activity

EXP

Leukotriene B4 results in decreased activity of MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

matrix metallopeptidase 9

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression

EXP

Leukotriene B4 results in increased expression of MUC5AC protein

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

nitric oxide synthase 2

multiple interactions

ISO

Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

phospholipase A2 group 4A

multiple interactions

ISO

PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4]; PLA2G4A protein promotes the reaction [Zymosan analog results in increased metabolism of Leukotriene B4]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

peroxisome proliferator activated receptor alpha

multiple interactions
affects binding

ISO

Leukotriene B4 binds to and results in increased activity of PPARA protein
Leukotriene B4 binds to PPARA protein

PMID:10403814 PMID:12009843 PMID:15491415

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

selectin L

increases expression

EXP

Leukotriene B4 results in increased expression of SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

transforming growth factor, beta 1

increases expression

ISO

Leukotriene B4 results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Methysergide results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

adrenoceptor alpha 1A

multiple interactions

EXP

Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

calcitonin-related polypeptide alpha

affects activity

EXP

Methysergide affects the activity of CALCA protein

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

5-hydroxytryptamine receptor 1B

affects binding

EXP

Methysergide binds to HTR1B protein

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583

G

5-hydroxytryptamine (serotonin) receptor 5B

multiple interactions

EXP

methysergide binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b]

RGD

NCBI chr13:35,239,662...35,252,586
Ensembl chr13:35,239,662...35,252,586

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 47 member 1

multiple interactions

ISO

Midodrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 1B

affects binding

ISO

naratriptan binds to HTR1B protein

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583

G

5-hydroxytryptamine receptor 1D

affects binding

ISO

naratriptan binds to HTR1D protein

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions
affects binding

ISO
EXP

[Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA1A protein; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]
Oxymetazoline binds to ADRA1A protein

PMID:8196478 PMID:15872040 PMID:20030735 PMID:21544540

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

multiple interactions
affects binding

ISO

Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Oxymetazoline binds to ADRA1B protein

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

multiple interactions
affects binding

ISO

Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
Oxymetazoline binds to ADRA1D protein

PMID:15493479 PMID:20030735

NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:139,246,323...139,262,331

G

adrenoceptor alpha 2A

multiple interactions
affects binding

ISO

Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
Oxymetazoline binds to ADRA2A protein

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

multiple interactions

ISO

[Oxymetazoline binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA2B protein; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor alpha 2C

affects binding
multiple interactions

ISO

Oxymetazoline binds to ADRA2C protein
Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]

NCBI chr14:79,695,514...79,697,476
Ensembl chr14:79,694,995...79,706,656

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

ISO

[CYP2C19 protein co-treated with NADP] results in increased metabolism of Oxymetazoline

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

solute carrier family 22 member 2

multiple interactions

ISO

Oxymetazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

P(1),P(5)-bis(5'-adenosyl) pentaphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

multiple interactions

ISO

P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

nudix hydrolase 11

multiple interactions
increases metabolic processing

ISO

[NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of adenosine 5'-tetraphosphate; [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate; manganese chloride promotes the reaction [NUDT11 protein results in increased metabolism of P(1),P(5)-di(adenosine-5'-)pentaphosphate]

NCBI chr X:18,998,587...19,005,208
Ensembl chr X:18,998,461...19,005,208

G

sirtuin 1

multiple interactions

EXP

P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

P(1),P(6)-bis(5'-adenosyl)hexaphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nudix hydrolase 11

multiple interactions
increases metabolic processing

ISO

[NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of adenosine 5'-pentaphosphate; [NUDT11 protein results in increased metabolism of diadenosine 5',5''''-P1,P6-hexaphosphate] which results in increased chemical synthesis of Adenosine Monophosphate

NCBI chr X:18,998,587...19,005,208
Ensembl chr X:18,998,461...19,005,208

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

multiple interactions

EXP

PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

angiotensinogen

multiple interactions
decreases response to substance
decreases activity

ISO
EXP

[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]
PD 123319 results in decreased susceptibility to AGT protein
PD 123319 results in decreased activity of AGT protein modified form
PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 promotes the reaction [AGT protein results in increased abundance of Prostaglandins E]
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]

PMID:9176287 PMID:9519251 PMID:11115077 PMID:14597853 PMID:14638905 More...

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

multiple interactions
decreases activity
increases expression
decreases expression

ISO
EXP

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 results in decreased activity of AGTR2 protein
PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein
[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 results in decreased expression of AGTR2 mRNA

PMID:9336375 PMID:9740612 PMID:11509473 PMID:11893553 PMID:15807884 More...

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

angiotensin II receptor-associated protein

multiple interactions

ISO

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]

NCBI chr 5:163,790,565...163,802,174
Ensembl chr 5:163,791,887...163,802,174

G

angiopoietin 1

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

angiopoietin 2

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:77,790,563...77,841,239

G

bradykinin receptor B2

multiple interactions

ISO

PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha]

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

C-C motif chemokine ligand 2

multiple interactions

EXP

PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 5

multiple interactions

EXP

PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cytochrome b-245 beta chain

multiple interactions

ISO

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

endothelin 1

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

Janus kinase 2

multiple interactions

ISO

PD123319 co-treated with losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver]

RGD

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

kinase insert domain receptor

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

kininogen 1

multiple interactions

ISO
EXP

PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]
PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]

PMID:11509473 PMID:16514058

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148

G

microtubule-associated protein 2

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase 1

multiple interactions

ISO

PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MDM2 proto-oncogene

multiple interactions

ISO

PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

microtubule associated scaffold protein 1

multiple interactions

EXP

PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 3

multiple interactions

ISO

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NADPH oxidase 1

multiple interactions

ISO

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

NADPH oxidase 4

multiple interactions

ISO

PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

protein kinase C, epsilon

increases expression

EXP

PD 123319 results in increased expression of PRKCE protein

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein tyrosine phosphatase, non-receptor type 6

multiple interactions

EXP

PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

secreted phosphoprotein 1

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

TEK receptor tyrosine kinase

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

tubulin, beta 3 class III

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

ubiquitin conjugating enzyme E2 V2

multiple interactions

ISO
EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]

PMID:16769992 PMID:17068200

NCBI chr11:98,808,681...98,842,583
Ensembl chr11:98,807,538...98,843,211

G

vascular endothelial growth factor A

multiple interactions

EXP

PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]

PMID:14638905 PMID:14718351

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

decreases expression

EXP

Phenylephrine results in decreased expression of ABCC9 mRNA

NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

EXP

Phenylephrine results in increased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions
increases phosphorylation
affects response to substance

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
Phenylephrine results in increased phosphorylation of ABL1 protein
ABL1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

ankyrin repeat and BTB domain containing 3

decreases expression

EXP

Phenylephrine results in decreased expression of ABTB3 mRNA

NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110

G

acyl-CoA dehydrogenase medium chain

multiple interactions
decreases expression

EXP

AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA]

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acetyl-CoA acetyltransferase 2

increases expression

EXP

Phenylephrine results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

angiotensin I converting enzyme

affects response to substance

ISO

ACE protein affects the susceptibility to Phenylephrine

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

acyl-CoA thioesterase 2

increases expression

EXP

Phenylephrine results in increased expression of ACOT2 mRNA

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

actin, alpha 1, skeletal muscle

multiple interactions
increases expression

ISO
EXP

[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]

PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More...

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

EXP

MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]

PMID:16556869 PMID:18158353

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

actin related protein 3

increases expression

EXP

Phenylephrine results in increased expression of ACTR3 mRNA

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

ADAM metallopeptidase domain 17

multiple interactions

EXP

ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

adenylate cyclase 5

increases response to substance

ISO

ADCY5 protein results in increased susceptibility to Phenylephrine

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

alcohol dehydrogenase, iron containing, 1

decreases expression

EXP

Phenylephrine results in decreased expression of ADHFE1 mRNA

NCBI chr 5:14,488,784...14,515,405
Ensembl chr 5:14,488,788...14,515,835

G

adrenomedullin

multiple interactions
increases expression
decreases secretion
decreases expression
decreases response to substance

EXP
ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in decreased expression of ADM mRNA
ADM protein results in decreased susceptibility to Phenylephrine

PMID:11470465 PMID:15370692 PMID:17250927

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

adenosine A1 receptor

multiple interactions
increases expression

EXP

1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190

G

adenosine A2a receptor

multiple interactions
increases expression

EXP

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adenosine A3 receptor

multiple interactions
increases expression

EXP

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein

NCBI chr 2:196,077,042...196,080,686
Ensembl chr 2:196,077,042...196,080,686

G

ADP-ribosylhydrolase like 1

increases expression

EXP

Phenylephrine results in increased expression of ADPRHL1 mRNA

NCBI chr16:82,985,355...83,017,240

G

adrenoceptor alpha 1A

multiple interactions
increases activity
affects activity
increases response to substance
affects binding
affects response to substance

ISO
EXP

5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein affects the susceptibility to Phenylephrine

PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More...

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

affects response to substance
multiple interactions
increases activity
decreases expression
increases response to substance

ISO
EXP

ADRA1B protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
ADRA1B protein results in increased susceptibility to Phenylephrine
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein

PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More...

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance

ISO
EXP

ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine

PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More...

NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:139,246,323...139,262,331

G

adrenoceptor alpha 2A

multiple interactions

ISO

Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

affects response to substance
multiple interactions

ISO

ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor beta 2

multiple interactions

EXP

[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

adrenoceptor beta 3

multiple interactions
increases response to substance

ISO

amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine]

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

angiotensinogen

affects response to substance
increases response to substance
multiple interactions
increases expression

EXP
ISO

AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]

PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

multiple interactions
affects response to substance

EXP
ISO

[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine

PMID:11714657 PMID:19151255

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Phenylephrine results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

adenylate kinase 4

increases expression

EXP

Phenylephrine results in increased expression of AK4 mRNA

NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation
affects phosphorylation

ISO
EXP

Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein

PMID:10679475 PMID:18084315 PMID:28759639

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aldehyde dehydrogenase 18 family, member A1

increases expression

EXP

Phenylephrine results in increased expression of ALDH18A1 mRNA

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:249,325,082...249,357,383

G

angiopoietin 1

multiple interactions
increases expression

ISO

ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

angiopoietin-like 4

decreases expression

EXP

Phenylephrine results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

apolipoprotein E

affects response to substance

ISO

APOE protein affects the susceptibility to Phenylephrine

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amphiregulin

increases expression

EXP

Phenylephrine results in increased expression of AREG mRNA

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

Rho guanine nucleotide exchange factor 12

decreases expression

EXP

Phenylephrine results in decreased expression of ARHGEF12 mRNA

NCBI chr 8:52,247,047...52,373,158
Ensembl chr 8:52,247,047...52,372,376

G

arrestin domain containing 3

decreases expression

EXP

Phenylephrine results in decreased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875

G

ankyrin repeat and SOCS box-containing 18

decreases expression

EXP

Phenylephrine results in decreased expression of ASB18 mRNA

NCBI chr 9:97,979,018...98,043,609
Ensembl chr 9:97,979,264...98,043,540

G

ankyrin repeat and SOCS box-containing 4

increases expression

EXP

Phenylephrine results in increased expression of ASB4 mRNA

NCBI chr 4:34,473,527...34,511,163
Ensembl chr 4:34,473,408...34,512,888

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

EXP

Phenylephrine results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

activating transcription factor 5

increases expression

EXP

Phenylephrine results in increased expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

EXP

Phenylephrine results in increased expression of ATP1B1 mRNA

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions
decreases expression
affects response to substance
increases expression
decreases activity

ISO
EXP

[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
ATP2A2 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of ATP2A2 mRNA
Phenylephrine results in decreased activity of ATP2A2 protein

PMID:11499749 PMID:11577024 PMID:15795322 PMID:16236312 PMID:17287366 More...

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATPase plasma membrane Ca2+ transporting 4

increases response to substance

ISO

ATP2B4 protein results in increased susceptibility to Phenylephrine

NCBI chr13:47,708,157...47,807,389
Ensembl chr13:47,711,121...47,758,876

G

ATPase phospholipid transporting 9A (putative)

increases expression

EXP

Phenylephrine results in increased expression of ATP9A mRNA

NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:177,779,203...178,023,661

G

ataxin 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]

NCBI chr17:18,943,397...19,354,751
Ensembl chr17:19,208,200...19,356,790

G

activator of transcription and developmental regulator AUTS2

decreases expression

EXP

Phenylephrine results in decreased expression of AUTS2 mRNA

NCBI chr12:29,739,138...30,830,386
Ensembl chr12:29,740,523...30,830,386

G

arginine vasopressin

multiple interactions
increases secretion

EXP

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]

PMID:2271928 PMID:11102496

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

arginine vasopressin-induced 1

increases expression

EXP

Phenylephrine results in increased expression of AVPI1 mRNA

NCBI chr 1:250,879,530...250,885,448
Ensembl chr 1:250,879,530...250,885,704

G

BCL2-associated agonist of cell death

increases expression

ISO

Phenylephrine results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BMP and activin membrane-bound inhibitor

increases expression

EXP

Phenylephrine results in increased expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression
multiple interactions

EXP
ISO

Phenylephrine results in decreased expression of BAX protein
Phenylephrine results in increased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]

PMID:19910689 PMID:31605733

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCAR1 scaffold protein, Cas family member

multiple interactions
increases phosphorylation

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression

EXP

Phenylephrine results in decreased expression of BCKDHA mRNA

NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:90,261,629...90,295,749

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

EXP
ISO

BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in decreased expression of BCL2 protein
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein

PMID:11042672 PMID:19910689 PMID:31605733 PMID:35979984

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

EXP
ISO

Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein

PMID:11042672 PMID:31605733 PMID:35979984

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

3-hydroxybutyrate dehydrogenase 1

increases expression

EXP

Phenylephrine results in increased expression of BDH1 mRNA

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

3-hydroxybutyrate dehydrogenase 2

decreases expression

EXP

Phenylephrine results in decreased expression of BDH2 mRNA

NCBI chr 2:226,376,346...226,397,010
Ensembl chr 2:226,376,356...226,397,006

G

bradykinin receptor B2

affects response to substance
increases expression

ISO
EXP

BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA

PMID:10614985 PMID:18158353

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

brain-derived neurotrophic factor

increases expression

EXP

Phenylephrine results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

bone morphogenetic protein 2

increases expression

EXP

phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

RGD

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

bone morphogenetic protein 4

increases expression

EXP

phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

RGD

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172

G

bone morphogenetic protein 7

decreases expression
increases expression

EXP

Phenylephrine results in decreased expression of BMP7 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

CTD
RGD

PMID:18158353 PMID:26873969

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137

G

BCL2 interacting protein 3 like

increases expression

EXP

Phenylephrine results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

boule homolog, RNA binding protein

decreases expression

EXP

Phenylephrine results in decreased expression of BOLL mRNA

NCBI chr 9:64,225,411...64,354,394
Ensembl chr 9:64,228,472...64,354,319

G

bromodomain containing 4

multiple interactions
increases expression

EXP

Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923

G

BTG anti-proliferation factor 3

increases expression

EXP

Phenylephrine results in increased expression of BTG3 mRNA

NCBI chr11:30,517,068...30,532,981
Ensembl chr11:30,517,072...30,533,082

G

carbonic anhydrase 1

decreases activity

ISO

Phenylephrine results in decreased activity of CA1 protein

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

carbonic anhydrase 4

increases expression

EXP

Phenylephrine results in increased expression of CA4 protein

NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916

G

calcineurin binding protein 1

multiple interactions

EXP

CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]

PMID:10655507 PMID:17060317

NCBI chr20:12,892,750...13,014,801
Ensembl chr20:12,892,771...13,014,800

G

calcium dependent secretion activator

decreases expression

EXP

Phenylephrine results in decreased expression of CADPS mRNA

NCBI chr15:14,719,078...15,173,218
Ensembl chr15:14,720,726...15,173,211

G

calcitonin-related polypeptide alpha

affects response to substance

ISO
EXP

CALCA protein affects the susceptibility to Phenylephrine

PMID:11728430 PMID:18055875

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

calcitonin receptor like receptor

multiple interactions

EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA

NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression

EXP

Phenylephrine results in decreased expression of CAMK2A mRNA

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

EXP

CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

carbonic anhydrase 2

increases expression
decreases activity

EXP
ISO

Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein

PMID:17124262 PMID:28800181

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 2

affects activity

ISO

Phenylephrine affects the activity of CASP2 protein

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

multiple interactions
increases activity

EXP
ISO

Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein

PMID:11042672 PMID:31605733

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

affects activity

ISO

Phenylephrine affects the activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity

ISO

Phenylephrine results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

calcium-sensing receptor

multiple interactions

EXP

Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]

NCBI chr11:77,738,398...77,813,639
Ensembl chr11:77,740,614...77,810,167

G

catalase

multiple interactions
decreases expression

EXP

CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein

PMID:16513848 PMID:18171680 PMID:20886221

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

multiple interactions

ISO

Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine]

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

caveolin 3

multiple interactions
decreases response to substance
affects localization
increases expression

ISO
EXP

CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CAV3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of CAV3 protein
Phenylephrine results in increased expression of CAV3 mRNA; Phenylephrine results in increased expression of CAV3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of CAV3 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of CAV3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased expression of CAV3 mRNA]; Cyclosporine inhibits the reaction [Phenylephrine results in increased expression of CAV3 protein]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of CAV3 mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of CAV3 protein]

PMID:12847114 PMID:15725944 PMID:19299911

NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:147,137,797...147,153,967

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

EXP

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein

PMID:15721863 PMID:15728586

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 27

increases expression

EXP

Phenylephrine results in increased expression of CCL27 mRNA

NCBI chr 5:61,737,261...61,744,375
Ensembl chr 5:61,737,261...61,743,522

G

cellular communication network factor 1

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

increases expression

EXP

Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin D1

multiple interactions
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein]

PMID:12163013 PMID:15603588

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

increases expression

EXP

Phenylephrine results in increased expression of CCND2 protein

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin D3

multiple interactions
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein]

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin T1

multiple interactions

EXP

Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]

NCBI chr 7:131,566,176...131,596,988
Ensembl chr 7:131,566,176...131,596,938

G

Cd200 molecule

decreases expression

EXP

Phenylephrine results in decreased expression of CD200 mRNA

NCBI chr11:68,916,200...68,943,570
Ensembl chr11:68,916,224...68,943,569

G

cadherin 2

increases expression

EXP

Phenylephrine results in increased expression of CDH2 protein

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin dependent kinase 2

increases expression

EXP

Phenylephrine results in increased expression of CDK2 protein

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

increases expression

EXP

Phenylephrine results in increased expression of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

increases expression
increases stability

ISO
EXP

Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA

PMID:10766810 PMID:15603588

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

EXP

Phenylephrine results in increased expression of CDKN1B

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein alpha

decreases expression

EXP

Phenylephrine results in decreased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CF transmembrane conductance regulator

multiple interactions

EXP

[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

EXP

Phenylephrine results in increased expression of CHCHD6 mRNA

NCBI chr 4:123,360,729...123,581,429
Ensembl chr 4:123,349,187...123,581,421

G

chloride intracellular channel 2

decreases expression

EXP

Phenylephrine results in decreased expression of CLIC2 mRNA

NCBI chr20:154,630...169,655
Ensembl chr20:154,255...169,648

G

chloride intracellular channel 4

increases expression

EXP

Phenylephrine results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

clusterin

increases expression

EXP

Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

calponin 1

increases expression

EXP

Phenylephrine results in increased expression of CNN1 mRNA

NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:28,908,330...28,919,482

G

collagen type XVIII alpha 1 chain

decreases expression

EXP

Phenylephrine results in decreased expression of COL18A1 mRNA

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collectin sub-family member 12

decreases expression

EXP

Phenylephrine results in decreased expression of COLEC12 mRNA

NCBI chr18:1,005,787...1,193,455
Ensembl chr18:1,005,741...1,195,297

G

corin, serine peptidase

increases expression

EXP

Phenylephrine results in increased expression of CORIN mRNA

NCBI chr14:36,034,613...36,264,671
Ensembl chr14:36,034,993...36,264,649

G

cytochrome c oxidase copper chaperone COX11

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of COX11 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]

PMID:23818984 PMID:25107896

NCBI chr10:75,955,825...75,962,398
Ensembl chr10:75,955,783...75,963,489

G

cytochrome c oxidase copper chaperone COX17

multiple interactions
decreases expression

EXP

Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]

PMID:23818984 PMID:25107896

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

cytochrome c oxidase subunit 4i1

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

carnitine palmitoyltransferase 1B

multiple interactions
decreases expression
increases expression

EXP

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein
Phenylephrine results in increased expression of CPT1B mRNA

PMID:11879187 PMID:15721863 PMID:19699196

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036

G

cAMP responsive element binding protein 1

multiple interactions

EXP

adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]

PMID:14741741 PMID:15522277

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

multiple interactions
increases response to substance

EXP

[Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine

PMID:11705990 PMID:12477714 PMID:15006641 PMID:15522277 PMID:19966502

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

cAMP responsive element modulator

increases expression

EXP

Phenylephrine results in increased expression of CREM mRNA

PMID:12791704 PMID:18158353

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

CRK proto-oncogene, adaptor protein

multiple interactions

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]

NCBI chr10:61,028,736...61,054,971
Ensembl chr10:61,028,757...61,082,988

G

casein kinase 2 alpha 1

decreases expression

EXP

Phenylephrine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

chondroitin sulfate proteoglycan 4

increases expression

EXP

Phenylephrine results in increased expression of CSPG4 mRNA

NCBI chr 8:66,160,942...66,195,987
Ensembl chr 8:66,160,942...66,200,806

G

cysteine and glycine-rich protein 2

increases expression

EXP

Phenylephrine results in increased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

cysteine and glycine rich protein 3

increases localization

EXP

Phenylephrine results in increased localization of CSRP3 protein

NCBI chr 1:107,664,338...107,682,916
Ensembl chr 1:107,664,338...107,682,916

G

cystathionine gamma-lyase

increases activity

EXP

Phenylephrine results in increased activity of CTH protein

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

catenin beta 1

multiple interactions

EXP

Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin C

decreases expression

EXP

Phenylephrine results in decreased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082

G

C-X-C motif chemokine ligand 1

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL10 mRNA

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 11

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL11 mRNA

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567

G

CXXC finger protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of CXXC4 mRNA

NCBI chr 2:225,329,044...225,363,347

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

EXP

Phenylephrine results in increased expression of CYP11B2 mRNA

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

EXP

Phenylephrine results in increased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions
increases response to substance
affects response to substance

EXP

20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]

PMID:11124159 PMID:12388396

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 51

increases expression

EXP

Phenylephrine results in increased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

death associated protein kinase 1

decreases expression

EXP

Phenylephrine results in decreased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

diacylglycerol kinase epsilon

multiple interactions

ISO

DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]

NCBI chr10:74,348,931...74,374,509
Ensembl chr10:74,350,246...74,374,478

G

diacylglycerol kinase zeta

multiple interactions

ISO

DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 3:98,359,804...98,401,847
Ensembl chr 3:98,359,804...98,401,951

G

7-dehydrocholesterol reductase

increases expression

EXP

Phenylephrine results in increased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

iodothyronine deiodinase 2

increases activity
increases expression

EXP

Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

dynein, axonemal, heavy chain 12

decreases expression

EXP

Phenylephrine results in decreased expression of DNAH12 mRNA

NCBI chr16:1,932,776...2,099,391
Ensembl chr16:1,944,752...2,099,373

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

EXP

Phenylephrine results in increased expression of DNAJB5 mRNA

NCBI chr 5:61,972,637...61,981,887
Ensembl chr 5:61,972,706...61,981,860

G

dynamin 1-like

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

double C2-like domains, gamma

decreases expression

EXP

Phenylephrine results in decreased expression of DOC2G mRNA

NCBI chr 1:210,724,868...210,729,352
Ensembl chr 1:210,725,748...210,730,048

G

dermatopontin

decreases expression

EXP

Phenylephrine results in decreased expression of DPT mRNA

NCBI chr13:79,656,341...79,684,759
Ensembl chr13:79,655,985...79,684,758

G

dual specificity phosphatase 1

increases expression

EXP

Phenylephrine results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 6

multiple interactions

EXP

DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

E2F transcription factor 3

increases expression

EXP

Phenylephrine results in increased expression of E2F3 protein

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 4

increases expression

EXP

Phenylephrine results in increased expression of E2F4 protein

NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834

G

E2F transcription factor 5

increases expression

EXP

Phenylephrine results in increased expression of E2F5 protein

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143

G

endothelin converting enzyme 1

increases expression

EXP

Phenylephrine results in increased expression of ECE1 mRNA

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

extracellular matrix protein 1

increases expression

EXP

Phenylephrine results in increased expression of ECM1 mRNA

NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606

G

endothelial differentiation-related factor 1

multiple interactions
increases expression
affects response to substance

EXP

MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
Phenylephrine results in increased expression of MBF1
MBF1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:28,764,906...28,779,499

G

endothelin 1

multiple interactions
increases response to substance
increases expression

ISO
EXP

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein

PMID:10788492 PMID:11739382 PMID:12724418 PMID:15007106 PMID:15220332 More...

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

multiple interactions

EXP

[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

endothelin receptor type B

increases expression

EXP

Phenylephrine results in increased expression of EDNRB protein

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

epidermal growth factor

multiple interactions

EXP

[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

ISO
EXP

Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
Phenylephrine results in increased phosphorylation of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:14676212 PMID:16760267 PMID:18360054

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

egl-9 family hypoxia-inducible factor 3

increases expression

EXP

Phenylephrine results in increased expression of EGLN3 mRNA

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015

G

early growth response 1

multiple interactions
increases expression

ISO
EXP

EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]

PMID:7905536 PMID:10710348 PMID:10779383 PMID:15621046

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 4E

multiple interactions
increases phosphorylation

EXP

CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
increases phosphorylation

EXP

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]

PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

ETS transcription factor ELK1

multiple interactions
increases phosphorylation
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

ELOVL fatty acid elongase 5

increases expression

EXP

Phenylephrine results in increased expression of ELOVL5 mRNA

NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:87,671,159...87,737,616

G

enolase 2

increases expression

EXP

Phenylephrine results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

enolase 3

increases expression

EXP

Phenylephrine results in increased expression of ENO3 mRNA

NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,866,101...55,874,540

G

E1A binding protein p300

multiple interactions
increases expression
increases response to substance

ISO
EXP

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
EP300 protein results in increased susceptibility to Phenylephrine

PMID:11705990 PMID:12477714 PMID:12724418 PMID:15006641 PMID:15220332 More...

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

endothelial PAS domain protein 1

decreases expression

EXP

Phenylephrine results in decreased expression of EPAS1 mRNA

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

erythrocyte membrane protein band 4.1 like 4B

increases expression

EXP

Phenylephrine results in increased expression of EPB41L4B mRNA

NCBI chr 5:76,486,886...76,647,752
Ensembl chr 5:76,486,902...76,647,752

G

Eph receptor A4

decreases expression

EXP

Phenylephrine results in decreased expression of EPHA4 mRNA

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

epoxide hydrolase 2

decreases expression

EXP

Phenylephrine results in decreased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

estrogen receptor 1

multiple interactions

ISO

ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

EYA transcriptional coactivator and phosphatase 2

multiple interactions

EXP

EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 3:174,754,772...174,938,035
Ensembl chr 3:174,818,554...174,938,034

G

fatty acid binding protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fatty acid desaturase 3

increases expression

EXP

Phenylephrine results in increased expression of FADS3 mRNA

NCBI chr 1:216,110,547...216,127,431
Ensembl chr 1:216,110,201...216,141,758

G

family with sequence similarity 110, member B

decreases expression

EXP

Phenylephrine results in decreased expression of FAM110B mRNA

NCBI chr 5:23,587,093...23,727,188
Ensembl chr 5:23,586,867...23,799,583

G

fibrillin 1

multiple interactions

ISO

FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]

NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283

G

ferredoxin 1

increases expression

EXP

Phenylephrine results in increased expression of FDX1 mRNA

NCBI chr 8:61,164,839...61,183,645
Ensembl chr 8:61,164,839...61,183,583

G

fibroblast growth factor 12

increases expression

EXP

Phenylephrine results in increased expression of FGF12 mRNA

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 18

increases expression

EXP

Phenylephrine results in increased expression of FGF18 mRNA

NCBI chr10:18,210,240...18,241,929
Ensembl chr10:18,210,512...18,240,933

G

fibroblast growth factor 2

multiple interactions

EXP

Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

four and a half LIM domains 1

increases expression

EXP

Phenylephrine results in increased expression of FHL1 mRNA

NCBI chr X:139,592,794...139,652,290
Ensembl chr X:139,592,604...139,652,282

G

four and a half LIM domains 2

decreases response to substance

EXP

FHL2 gene mutant form results in decreased susceptibility to Phenylephrine

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

fission, mitochondrial 1

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of FIS1 protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

Fms related receptor tyrosine kinase 1

multiple interactions
increases expression

EXP

FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein

PMID:19542178 PMID:24903162

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

fibronectin 1

increases expression

ISO

Phenylephrine results in increased expression of FN1 protein

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects expression
affects response to substance
increases expression

ISO
EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; U 0126 inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]
Phenylephrine affects the expression of FOS protein
FOS protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of FOS; Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; Troglitazone inhibits the reaction [Phenylephrine results in increased expression of FOS protein]

PMID:7844257 PMID:7900855 PMID:7905536 PMID:8750937 PMID:8809800 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases activity
increases expression

EXP

Phenylephrine results in increased activity of FOSB protein
Phenylephrine results in increased expression of FOSB

PMID:7905536 PMID:15949472

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

forkhead box O1

multiple interactions

EXP

Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

follistatin like 3

affects expression

EXP

Phenylephrine affects the expression of FSTL3 mRNA

NCBI chr 7:10,574,195...10,579,844
Ensembl chr 7:10,574,186...10,590,509

G

FXYD domain-containing ion transport regulator 5

increases expression

EXP

Phenylephrine results in increased expression of FXYD5 mRNA

NCBI chr 1:95,395,327...95,404,722
Ensembl chr 1:95,395,146...95,405,364

G

polypeptide N-acetylgalactosaminyltransferase 13

decreases expression

EXP

Phenylephrine results in decreased expression of GALNT13 mRNA

NCBI chr 3:59,312,628...59,969,633
Ensembl chr 3:59,383,516...59,965,379

G

guanidinoacetate N-methyltransferase

decreases expression

EXP

Phenylephrine results in decreased expression of GAMT mRNA

NCBI chr 7:10,099,267...10,102,083
Ensembl chr 7:10,098,571...10,102,083

G

GATA binding protein 4

multiple interactions
increases expression
increases acetylation
affects response to substance
increases activity

ISO
EXP

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of GATA4 protein
Phenylephrine results in increased acetylation of GATA4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein; Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]
GATA4 protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA

PMID:10710348 PMID:10788492 PMID:11739382 PMID:12724418 PMID:15220332 More...

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

growth differentiation factor 15

affects expression

ISO

Phenylephrine affects the expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

gamma-glutamyltransferase 1

multiple interactions

ISO

Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, alpha 1

multiple interactions
increases expression
affects response to substance

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein
GJA1 protein affects the susceptibility to Phenylephrine

PMID:16352648 PMID:18445782 PMID:18593691

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

gap junction protein, alpha 5

decreases expression

EXP

Phenylephrine results in decreased expression of GJA5 mRNA

NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512

G

galactosidase, alpha

affects response to substance

ISO

GLA protein affects the susceptibility to Phenylephrine

NCBI chr X:102,062,497...102,073,915
Ensembl chr X:102,056,718...102,073,915

G

glutaredoxin 3

affects response to substance
increases expression
multiple interactions

EXP

GLRX3 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of GLRX3 mRNA
GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glia maturation factor, gamma

increases expression

EXP

Phenylephrine results in increased expression of GMFG mRNA

NCBI chr 1:92,856,154...92,866,722
Ensembl chr 1:92,854,995...92,866,723

G

G protein subunit alpha q

multiple interactions

EXP

RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742

G

GNAS complex locus

affects response to substance

EXP

GNAS protein affects the susceptibility to Phenylephrine

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536

G

gonadotropin releasing hormone 1

multiple interactions
increases secretion
decreases secretion

EXP

alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein]; Testosterone affects the reaction [Phenylephrine affects the secretion of GNRH1 protein]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

glycoprotein m6a

decreases expression

EXP

Phenylephrine results in decreased expression of GPM6A mRNA

NCBI chr16:43,374,385...43,706,461
Ensembl chr16:43,374,385...43,706,705

G

G protein-coupled receptor kinase 2

multiple interactions
increases expression

ISO
EXP

[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein
Phenylephrine results in increased expression of GRK2 protein
GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]

PMID:11499749 PMID:28759639

NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

EXP

GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]

PMID:15795328 PMID:28759639

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione S-transferase kappa 1

decreases expression

EXP

Phenylephrine results in decreased expression of GSTK1 mRNA

NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927

G

glutathione S-transferase, mu 5

decreases expression

EXP

Phenylephrine results in decreased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glycogen synthase 2

decreases activity

EXP

Phenylephrine results in decreased activity of GYS2 protein

NCBI chr 4:177,096,063...177,137,236
Ensembl chr 4:177,096,063...177,137,236

G

hepcidin antimicrobial peptide

decreases expression

EXP

Phenylephrine results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

heparin-binding EGF-like growth factor

increases expression

EXP

Phenylephrine results in increased expression of DTR mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

histone deacetylase 5

multiple interactions

ISO

[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein

NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244

G

HDGF like 2

decreases expression

EXP

Phenylephrine results in decreased expression of HDGFL2 mRNA

NCBI chr 9:996,687...1,016,352
Ensembl chr 9:996,758...1,016,735

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

increases expression

EXP

Phenylephrine results in increased expression of HERC3 mRNA

NCBI chr 4:89,282,374...89,372,656
Ensembl chr 4:89,282,445...89,372,652

G

HEXIM P-TEFb complex subunit 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]

NCBI chr10:88,562,889...88,565,001
Ensembl chr10:88,560,519...88,580,000

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
decreases expression
decreases response to substance

ISO

HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in decreased expression of HEY2 mRNA
HEY2 protein results in decreased susceptibility to Phenylephrine

PMID:16603706 PMID:20001863

NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:28,641,057...28,651,187

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

EXP

Phenylephrine results in increased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

EXP

Phenylephrine results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

homer scaffold protein 1

increases expression

EXP

Phenylephrine results in increased expression of HOMER1 mRNA alternative form

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

heat shock protein family B (small) member 3

increases expression

EXP

Phenylephrine results in increased expression of HSPB3 mRNA

NCBI chr 2:47,028,451...47,029,165
Ensembl chr 2:47,024,757...47,029,373

G

inhibitor of DNA binding 1

increases expression
increases expression

EXP

Phenylephrine results in increased expression of ID1 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

CTD
RGD

PMID:18158353 PMID:26873969

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 4

increases expression

EXP

Phenylephrine results in increased expression of ID4 mRNA

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

isopentenyl-diphosphate delta isomerase 1

increases expression

EXP

Phenylephrine results in increased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

immediate early response 3

decreases response to substance
affects localization

ISO

IER3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of IER3 protein

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

insulin-like growth factor 1

affects response to substance

EXP

IGF1 protein affects the susceptibility to Phenylephrine

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein 4

affects response to substance

EXP

IGFBP4 protein affects the susceptibility to Phenylephrine

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

insulin-like growth factor binding protein 5

decreases expression

EXP

Phenylephrine results in decreased expression of IGFBP5 mRNA

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390

G

interferon gamma induced GTPase

decreases expression

EXP

Phenylephrine results in decreased expression of IGTP mRNA

NCBI chr10:42,875,047...42,882,866
Ensembl chr10:42,876,790...42,882,858

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases activity
multiple interactions

EXP

Phenylephrine results in increased activity of IKBKB protein
IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions
decreases response to substance
affects response to substance

EXP

Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]
IL1B protein results in decreased susceptibility to Phenylephrine

PMID:11506125 PMID:13679239

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases expression
decreases expression
multiple interactions

EXP

Phenylephrine results in increased expression of IL6 mRNA
Phenylephrine results in decreased expression of IL6 mRNA
[resveratrol co-treated with Phenylephrine] results in increased expression of IL6 mRNA

PMID:11406463 PMID:12423672 PMID:22748497

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin-linked kinase

multiple interactions
affects localization

ISO
EXP

Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine affects the localization of ILK protein
ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:16170337 PMID:18502941

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

inhibin subunit alpha

increases expression

EXP

Phenylephrine results in increased expression of INHA mRNA

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009

G

interferon regulatory factor 7

decreases expression

EXP

Phenylephrine results in decreased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

ISG15 ubiquitin-like modifier

decreases expression

EXP

Phenylephrine results in decreased expression of ISG15 mRNA

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656

G

integrin subunit alpha 9

increases expression

EXP

Phenylephrine results in increased expression of ITGA9 mRNA

NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:127,169,226...127,493,296

G

integrin subunit beta 3 binding protein

increases expression

EXP

Phenylephrine results in increased expression of ITGB3BP mRNA

NCBI chr 5:119,575,657...119,640,974
Ensembl chr 5:119,575,248...119,640,997

G

integrin subunit beta 8

increases expression

EXP

Phenylephrine results in increased expression of ITGB8 mRNA

NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:146,165,484...146,351,245

G

inositol 1,4,5-trisphosphate receptor, type 2

increases activity
multiple interactions

ISO

Phenylephrine results in increased activity of ITPR2 protein
[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA

NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:180,760,442...181,164,763

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation
increases expression
increases activity
affects response to substance

ISO
EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]
Phenylephrine results in increased phosphorylation of JUN protein
Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein
Phenylephrine results in increased activity of JUN protein
JUN protein affects the susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]

PMID:7905536 PMID:10710348 PMID:11799083 PMID:12169099 PMID:12574153 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression
increases activity

EXP

Phenylephrine results in increased expression of JUNB
Phenylephrine results in increased activity of JUNB protein

PMID:7905536 PMID:15949472

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

ISO

JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

potassium voltage-gated channel subfamily D member 2

multiple interactions
decreases expression
decreases response to substance

EXP

CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of KCND2 mRNA; Phenylephrine results in decreased expression of KCND2 protein
KCND2 protein results in decreased susceptibility to Phenylephrine

PMID:12403671 PMID:16385079 PMID:17060317

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium voltage-gated channel subfamily D member 3

multiple interactions
decreases expression

ISO
EXP

[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]
Phenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 protein

PMID:11249870 PMID:11709419 PMID:16385079 PMID:17060317

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

ISO

Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium]

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel interacting protein 2

multiple interactions
decreases expression

EXP

MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]
Phenylephrine results in decreased expression of KCNIP2 mRNA; Phenylephrine results in decreased expression of KCNIP2 mRNA alternative form; Phenylephrine results in decreased expression of KCNIP2 protein

PMID:16385079 PMID:17060317 PMID:18158353

NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:254,590,175...254,613,898

G

KDEL endoplasmic reticulum protein retention receptor 3

increases expression

EXP

Phenylephrine results in increased expression of KDELR3 mRNA

NCBI chr 7:112,959,632...112,969,858
Ensembl chr 7:112,959,718...112,969,858

G

kinase insert domain receptor

decreases expression
multiple interactions
increases expression

EXP

Phenylephrine results in decreased expression of KDR mRNA
Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]

PMID:18158353 PMID:24903162

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

kinesin family member 5B

decreases expression

EXP

Phenylephrine results in decreased expression of KIF5B mRNA

NCBI chr17:56,185,386...56,222,990
Ensembl chr17:56,185,380...56,223,008

G

KLF transcription factor 4

multiple interactions
decreases expression

EXP

Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]
Phenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 protein

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

kelch-like family member 24

decreases expression

EXP

Phenylephrine results in decreased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

lysine methyltransferase 2E

decreases expression

EXP

Phenylephrine results in decreased expression of KMT2E mRNA

NCBI chr 4:12,550,570...12,655,329
Ensembl chr 4:12,550,570...12,619,721

G

laminin subunit gamma 1

increases expression

EXP

Phenylephrine results in increased expression of LAMC1 mRNA

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986

G

laminin subunit gamma 2

increases expression

EXP

Phenylephrine results in increased expression of LAMC2 mRNA

NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102

G

low density lipoprotein receptor

increases expression

EXP

Phenylephrine results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

galectin 3 binding protein

decreases expression

EXP

Phenylephrine results in decreased expression of LGALS3BP mRNA

NCBI chr10:104,118,510...104,127,848
Ensembl chr10:104,118,510...104,127,848

G

LIM zinc finger domain containing 1

affects localization

EXP

Phenylephrine affects the localization of LIMS1 protein

NCBI chr20:26,851,364...26,961,607
Ensembl chr20:26,852,996...26,961,606

G

LIM and cysteine-rich domains 1

increases expression

EXP

Phenylephrine results in increased expression of LMCD1 mRNA

NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875

G

lipoprotein lipase

affects response to substance

ISO

LPL protein affects the susceptibility to Phenylephrine

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine rich repeat containing 27

decreases expression

EXP

Phenylephrine results in decreased expression of LRRC27 mRNA

NCBI chr 1:203,433,463...203,464,683
Ensembl chr 1:203,434,355...203,464,676

G

LYL1, basic helix-loop-helix family member

increases expression

EXP

Phenylephrine results in increased expression of LYL1 mRNA

NCBI chr19:40,356,967...40,359,834
Ensembl chr19:40,354,819...40,359,834

G

MAF bZIP transcription factor K

increases expression

EXP

Phenylephrine results in increased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

mannosidase, alpha, class 1A, member 1

decreases expression

EXP

Phenylephrine results in decreased expression of MAN1A mRNA

NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,745,165...33,928,584

G

monoamine oxidase A

multiple interactions

ISO

[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

multiple interactions

ISO

[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 1

multiple interactions

EXP

MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions

EXP

MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions
increases activity

EXP

CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]; KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase kinase kinase 7

increases phosphorylation
multiple interactions

EXP

phenylephrin increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes
Phenylephrine promotes the reaction [Map3k7 protein binds to Tab1 protein in neonatal cardiomyocytes]
Phenylephrine promotes the reaction [Map3k7 protein binds to Ripk2 protein]
Phenylephrine increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes

RGD

PMID:32971071 PMID:35352799 PMID:34733837 PMID:35490166

RGD:155791643, RGD:155804287, RGD:155791674, RGD:155791668

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation

ISO
EXP

[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Phenylephrine results in increased expression of MAPK1 protein modified form
Phenylephrine results in increased activity of MAPK1 protein
Phenylephrine affects the phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]

PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

multiple interactions

ISO

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen activated protein kinase 14

increases phosphorylation

EXP

Phenylephrine results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation

ISO
EXP

[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of MAPK3 protein modified form
Phenylephrine results in increased activity of MAPK3 protein
Phenylephrine affects the phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 7

multiple interactions

EXP

Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

EXP

GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
Phenylephrine results in increased phosphorylation of MAPK8 protein

PMID:10727428 PMID:16385079 PMID:16517124 PMID:16809552

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 8 interacting protein 1

affects response to substance
multiple interactions

EXP

MAPK8IP1 protein affects the susceptibility to Phenylephrine
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:98,810,541...98,828,368

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation
affects response to substance

ISO
EXP

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]
Phenylephrine results in increased phosphorylation of MAPK9 protein

PMID:10727428 PMID:16949803

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MBL associated serine protease 1

decreases expression

EXP

Phenylephrine results in decreased expression of MASP1 mRNA

NCBI chr11:90,839,081...90,909,922
Ensembl chr11:90,839,061...90,917,470

G

myocyte enhancer factor 2C

multiple interactions
increases expression
increases activity

ISO
EXP

Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]
Phenylephrine results in increased expression of MEF2C mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]

PMID:10737771 PMID:19124542

NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640

G

microfibril associated protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of MFAP4 mRNA

NCBI chr10:46,666,552...46,669,613
Ensembl chr10:46,655,722...46,669,740

G

multifunctional ROCO family signaling regulator 1

decreases expression

EXP

Phenylephrine results in decreased expression of MFHAS1 mRNA

NCBI chr16:63,248,833...63,336,441
Ensembl chr16:63,250,455...63,336,602

G

mitofusin 2

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of MFN2 mRNA; Phenylephrine results in decreased expression of MFN2 protein
CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]

PMID:17499311 PMID:20886221

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

monoglyceride lipase

decreases expression

EXP

Phenylephrine results in decreased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

microRNA 21

increases expression

EXP

Phenylephrine results in increased expression of MIR21 mRNA

NCBI chr10:71,902,600...71,902,691

G

mixed lineage kinase domain like pseudokinase

increases expression

ISO

Phenylephrine results in increased expression of MLKL protein

NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858

G

MLLT11, transcription factor 7 cofactor

increases expression

EXP

Phenylephrine results in increased expression of MLLT11 mRNA

NCBI chr 2:185,484,791...185,493,961
Ensembl chr 2:185,484,793...185,493,961

G

matrix metallopeptidase 2

multiple interactions

ISO
EXP

MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]

PMID:16251426 PMID:16980344

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

increases expression

ISO

Phenylephrine results in increased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

Mov10 like RNA helicase 1

multiple interactions

ISO
EXP

MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:11854500 PMID:12754203

NCBI chr 7:121,949,743...122,015,042
Ensembl chr 7:121,949,822...122,015,042

G

methylsterol monooxygenase 1

increases expression

EXP

Phenylephrine results in increased expression of MSMO1 mRNA

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445

G

moesin

increases expression

EXP

Phenylephrine results in increased expression of MSN mRNA

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:65,005,458...65,075,129

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

EXP

Phenylephrine results in increased expression of MTHFD1L mRNA

NCBI chr 1:42,849,424...43,038,313
Ensembl chr 1:42,849,374...43,038,309

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

musculoskeletal, embryonic nuclear protein 1

increases expression

EXP

Phenylephrine results in increased expression of MUSTN1 mRNA

NCBI chr16:6,079,355...6,081,608
Ensembl chr16:6,079,277...6,081,586

G

MYB proto-oncogene like 1

increases expression

EXP

Phenylephrine results in increased expression of MYBL1 mRNA

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

myosin binding protein C3

multiple interactions

ISO

MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]

NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:97,551,061...97,569,216

G

myosin heavy chain 14

decreases expression

EXP

Phenylephrine results in decreased expression of MYH14 mRNA

NCBI chr 1:104,232,778...104,295,369
Ensembl chr 1:104,232,778...104,323,404

G

myosin heavy chain 6

multiple interactions
decreases expression

EXP

Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]; THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]

PMID:11577024 PMID:15578571 PMID:15795322 PMID:17592507

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

multiple interactions
increases expression

ISO
EXP

CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]
Phenylephrine results in increased expression of MYH7 mRNA
Phenylephrine results in increased expression of MYH7 mRNA; Phenylephrine results in increased expression of MYH7 protein
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; spiruchostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

PMID:10642269 PMID:10710348 PMID:11249870 PMID:11513749 PMID:11577024 More...

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin, light chain 1

increases expression

EXP

Phenylephrine results in increased expression of MYL1 mRNA

Ensembl chr 9:75,887,227...75,907,971

G

myosin light chain 2

multiple interactions
increases phosphorylation
increases expression

EXP

ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]
Phenylephrine results in increased phosphorylation of MYL2 protein

PMID:11470465 PMID:11513749 PMID:14676212 PMID:15007106 PMID:18202317

NCBI chr12:40,114,964...40,126,236
Ensembl chr12:40,114,958...40,129,149

G

myosin light chain 7

multiple interactions
increases phosphorylation

ISO

ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]

NCBI chr14:84,994,644...84,997,173
Ensembl chr14:84,993,736...84,997,372

G

myosin light chain 9

increases phosphorylation

EXP

Phenylephrine results in increased phosphorylation of MYL9 protein

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myosin light chain kinase 3

increases phosphorylation

ISO

Phenylephrine results in increased phosphorylation of MYLK3 protein

NCBI chr19:37,858,298...37,916,805
Ensembl chr19:37,865,141...37,915,827

G

myocardin

multiple interactions
increases expression

EXP

MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]
Phenylephrine results in increased expression of MYOCD mRNA; Phenylephrine results in increased expression of MYOCD protein

PMID:14676212 PMID:16556869

NCBI chr10:50,332,356...50,426,819
Ensembl chr10:50,332,356...50,426,819

G

myozenin 2

multiple interactions
decreases response to substance

ISO

MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
MYOZ2 protein results in decreased susceptibility to Phenylephrine

NCBI chr 2:213,826,052...213,852,778
Ensembl chr 2:213,826,052...213,852,914

G

Ngfi-A binding protein 1

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA

NCBI chr 9:56,545,547...56,585,045
Ensembl chr 9:56,545,729...56,614,210

G

Ngfi-A binding protein 2

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]

NCBI chr 7:65,382,863...65,389,527
Ensembl chr 7:65,382,863...65,389,255

G

neurocalcin delta

increases expression

EXP

Phenylephrine results in increased expression of NCALD mRNA

NCBI chr 7:70,417,683...70,849,763
Ensembl chr 7:70,419,433...70,849,482

G

neutrophil cytosolic factor 1

increases phosphorylation
increases expression

EXP
ISO

Phenylephrine results in increased phosphorylation of NCF1 protein
Phenylephrine results in increased expression of NCF1 mRNA

PMID:14656924 PMID:15936005

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

nuclear factor of activated T-cells 1

multiple interactions
affects localization

EXP

Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein; sanggenone C inhibits the reaction [Phenylephrine affects the localization of NFATC1 protein]

PMID:12403671 PMID:19349967 PMID:28849031

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

nuclear factor of activated T-cells 3

increases localization
multiple interactions

ISO

Phenylephrine results in increased localization of NFATC3 protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]

NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992

G

nuclear factor of activated T-cells 4

multiple interactions
increases localization
affects localization

ISO
EXP

Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
Phenylephrine affects the localization of NFATC4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]

PMID:11044444 PMID:16055480

NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582

G

nuclear factor, interleukin 3 regulated

multiple interactions

ISO

U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA]

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

NFKB inhibitor alpha

multiple interactions
increases degradation
decreases expression

EXP

4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:11381115 PMID:15629441 PMID:16421291

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nidogen 2

increases expression

EXP

Phenylephrine results in increased expression of NID2 mRNA

NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,506,756...4,562,949

G

NK2 homeobox 5

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA

NCBI chr10:16,844,888...16,851,458
Ensembl chr10:16,848,582...16,851,452

G

nodal growth differentiation factor

affects expression

EXP

Phenylephrine affects the expression of NODAL mRNA; Phenylephrine affects the expression of NODAL protein

NCBI chr20:29,911,258...29,919,659
Ensembl chr20:29,911,258...29,919,659

G

nucleolar protein 3

decreases phosphorylation

EXP

Phenylephrine results in decreased phosphorylation of NOL3 protein

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

nitric oxide synthase 2

multiple interactions
increases activity
decreases response to substance
affects response to substance

ISO
EXP

NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Calcimycin]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
Phenylephrine results in increased activity of NOS2 protein
NOS2 protein results in decreased susceptibility to Phenylephrine
NOS2 protein affects the susceptibility to Phenylephrine

PMID:11498454 PMID:15753950 PMID:15902277

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

affects response to substance
decreases response to substance
multiple interactions
increases expression

ISO
EXP

NOS3 protein affects the susceptibility to Phenylephrine
NOS3 protein results in decreased susceptibility to Phenylephrine
NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]
Phenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 protein

PMID:10954898 PMID:11504159 PMID:15381055 PMID:15753950 PMID:17403420

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

natriuretic peptide A

increases secretion
increases expression
multiple interactions
decreases response to substance

ISO
EXP

Phenylephrine results in increased secretion of NPPA protein
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes
Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
NPPA protein results in decreased susceptibility to Phenylephrine
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

CTD
RGD

PMID:2847676 PMID:8188982 PMID:10642269 PMID:10655507 PMID:10679475 More...

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

multiple interactions
increases expression
increases secretion

ISO
EXP

ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes
Phenylephrine results in increased expression of NPPB mRNA; Phenylephrine results in increased expression of NPPB protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

CTD
RGD

PMID:10642269 PMID:11754973 PMID:11799083 PMID:11804996 PMID:11854500 More...

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

natriuretic peptide C

affects response to substance
multiple interactions

EXP

NPPC protein affects the susceptibility to Phenylephrine
SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]

NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186

G

natriuretic peptide receptor 1

multiple interactions

ISO

[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]

NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:178,231,766...178,247,088

G

neuropeptide Y

multiple interactions

ISO

[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]

PMID:10660688 PMID:11499749

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

neuropeptide Y receptor Y5

multiple interactions

ISO

NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]

NCBI chr16:27,822,055...27,830,012
Ensembl chr16:27,816,065...27,830,290

G

nuclear receptor subfamily 1, group I, member 2

affects response to substance

ISO

NR1I2 protein affects the susceptibility to Phenylephrine

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 3, group C, member 1

increases expression

EXP

Phenylephrine results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions
increases expression

EXP

Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of NR3C2 protein; Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Phenylephrine results in increased expression of NR3C2 mRNA

PMID:16533503 PMID:19966502

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

nuclear receptor subfamily 4, group A, member 3

increases expression

EXP

Phenylephrine results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

neuronal regeneration related protein

decreases expression

EXP

Phenylephrine results in decreased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

neuregulin 1

decreases expression

EXP

Phenylephrine results in decreased expression of NRG1 mRNA; Phenylephrine results in decreased expression of NRG1 protein

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neurotensin

decreases response to substance

EXP

NTS protein results in decreased susceptibility to Phenylephrine

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

G

nucleoporin 62

multiple interactions
decreases expression

EXP

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; trichostatin A inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]

NCBI chr 1:104,435,532...104,451,392
Ensembl chr 1:104,432,093...104,452,710

G

osteoglycin

decreases expression

EXP

Phenylephrine results in decreased expression of OGN mRNA

NCBI chr17:15,238,500...15,259,167
Ensembl chr17:15,238,500...15,259,252

G

oxytocin/neurophysin I prepropeptide

multiple interactions
increases secretion

EXP

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]

PMID:11102496 PMID:15149956

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594

G

purinergic receptor P2X 5

increases expression

EXP

Phenylephrine results in increased expression of P2RX5 mRNA

NCBI chr10:58,276,329...58,291,108
Ensembl chr10:58,276,257...58,287,935

G

prolyl 4-hydroxylase subunit alpha 1

increases expression

EXP

Phenylephrine results in increased expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

proton activated chloride channel 1

decreases expression

EXP

Phenylephrine results in decreased expression of PACC1 mRNA

NCBI chr13:105,435,772...105,460,877
Ensembl chr13:105,435,799...105,461,095

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]; Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]; Phenylephrine inhibits the reaction [Iodine-131 results in decreased expression of PAFAH1B1 protein]

NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196

G

poly (ADP-ribose) polymerase 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

parvin, alpha

affects localization

EXP

Phenylephrine affects the localization of PARVA protein

NCBI chr 1:175,981,725...176,139,523
Ensembl chr 1:175,981,432...176,139,526

G

proliferating cell nuclear antigen

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of PCNA protein
Phenylephrine promotes the reaction [Iodine-131 results in increased expression of PCNA protein]

PMID:15603588 PMID:32278511

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

Purkinje cell protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of PCP4 mRNA

NCBI chr11:49,229,185...49,331,186
Ensembl chr11:49,270,186...49,331,186

G

proprotein convertase subtilisin/kexin type 6

increases expression

EXP

Phenylephrine results in increased expression of PCSK6 mRNA

NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:128,839,232...129,052,128

G

phosphodiesterase 1A

multiple interactions

EXP

PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]

NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212

G

phosphodiesterase 4B

increases expression

EXP

Phenylephrine results in increased expression of PDE4B mRNA

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

phosphodiesterase 5A

multiple interactions

EXP

PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

pyruvate dehydrogenase kinase 2

decreases expression

EXP

Phenylephrine results in decreased expression of PDK2 mRNA

NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355

G

pyruvate dehydrogenase kinase 4

multiple interactions
decreases expression

EXP

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]

PMID:15721863 PMID:15728586

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 3

increases expression

EXP

Phenylephrine results in increased expression of PDLIM3 mRNA

NCBI chr16:53,085,020...53,116,495
Ensembl chr16:53,085,020...53,116,217

G

proliferation and apoptosis adaptor protein 15

increases expression

EXP

Phenylephrine results in increased expression of PEA15 mRNA

NCBI chr13:87,190,189...87,199,811
Ensembl chr13:87,187,295...87,199,859

G

period circadian regulator 1

multiple interactions

ISO

U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

multiple interactions

ISO

U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA]

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

peroxisomal biogenesis factor 11 alpha

decreases expression

EXP

Phenylephrine results in decreased expression of PEX11A mRNA

NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645

G

phosphofructokinase, liver type

increases expression

EXP

Phenylephrine results in increased expression of PFKL mRNA

NCBI chr20:10,663,907...10,685,967
Ensembl chr20:10,663,955...10,685,966

G

phosphoglycerate dehydrogenase

increases expression

EXP

Phenylephrine results in increased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

pleckstrin homology-like domain, family A, member 1

increases expression

EXP

Phenylephrine results in increased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

polycystin 1, transient receptor potential channel interacting

affects response to substance

ISO

PKD1 protein affects the susceptibility to Phenylephrine

NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681

G

pyruvate kinase L/R

multiple interactions
decreases activity

EXP

Calcium inhibits the reaction [Phenylephrine results in decreased activity of PKLR protein]

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

plakophilin 4

decreases expression

EXP

Phenylephrine results in decreased expression of PKP4 mRNA

NCBI chr 3:64,040,995...64,244,586
Ensembl chr 3:64,141,771...64,244,586

G

phospholipase A2 group IIA

decreases expression

EXP

Phenylephrine results in decreased expression of PLA2G2A mRNA

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

phospholipase A2 group VI

affects response to substance

EXP

PLA2G6 protein affects the susceptibility to Phenylephrine

NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609

G

phospholipase A and acyltransferase 1

increases expression

EXP

Phenylephrine results in increased expression of PLAAT1 mRNA

NCBI chr11:85,022,297...85,041,999
Ensembl chr11:85,022,297...85,031,826

G

phospholipase C beta 1

increases expression

EXP

Phenylephrine results in increased expression of PLCB1 mRNA

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

phospholipase C beta 3

increases expression

EXP

Phenylephrine results in increased expression of PLCB3 mRNA

NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583

G

phospholipase C, delta 1

increases expression

EXP

Phenylephrine results in increased expression of PLCD1 mRNA

NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939

G

phospholipase C, gamma 1

increases expression

EXP

Phenylephrine results in increased expression of PLCG1 mRNA

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

proopiomelanocortin

multiple interactions
increases response to substance
increases secretion

EXP
ISO

Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]
POMC protein results in increased susceptibility to Phenylephrine

PMID:2822310 PMID:3015460 PMID:10898105

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

EXP

[pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein]
Phenylephrine results in decreased expression of PPARA mRNA; Phenylephrine results in decreased expression of PPARA protein

PMID:18701451 PMID:19699196

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

multiple interactions

EXP

[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:15721863 PMID:18701451

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions
increases phosphorylation

EXP

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]

PMID:24449418 PMID:25449040

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

protein phosphatase 1, regulatory (inhibitor) subunit 14A

multiple interactions
increases phosphorylation

EXP

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]

NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147

G

protein phosphatase 3 catalytic subunit beta

increases expression
increases activity
multiple interactions

ISO
EXP

Phenylephrine results in increased expression of PPP3CB mRNA
Phenylephrine results in increased expression of PPP3CB mRNA; Phenylephrine results in increased expression of PPP3CB protein
Phenylephrine results in increased activity of PPP3CB protein
CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]

PMID:10655507 PMID:16024800

NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,809,262...3,854,203

G

protein kinase C, alpha

multiple interactions
increases expression
increases activity
increases localization

ISO
EXP

DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]
Phenylephrine results in increased expression of PRKCA protein modified form
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein
Phenylephrine results in increased activity of PRKCA protein

PMID:12435817 PMID:16809552 PMID:18487437 PMID:21565836

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

multiple interactions
increases expression

EXP

Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, delta

increases expression
affects localization

EXP

Phenylephrine results in increased expression of PRKCD protein
Phenylephrine affects the localization of PRKCD protein

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase C, epsilon

multiple interactions
increases expression
affects localization
increases localization

ISO
EXP

DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]
Phenylephrine results in increased expression of PRKCE protein
Phenylephrine affects the localization of PRKCE protein
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein

PMID:12003851 PMID:12700091 PMID:12720544 PMID:16809552 PMID:18487437

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, zeta

affects localization
increases phosphorylation
decreases activity
multiple interactions

EXP

Phenylephrine affects the localization of PRKCZ protein
Phenylephrine results in increased phosphorylation of PRKCZ protein
Phenylephrine results in decreased activity of PRKCZ protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]

PMID:14736339 PMID:16809552 PMID:27094369

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

protein kinase D1

affects localization
increases phosphorylation
multiple interactions
increases activity

ISO
EXP

Phenylephrine affects the localization of PRKD1 protein
Phenylephrine increases phosphorylation of Prkd1 protein in neonatal ventricular myocytes
[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein

CTD
RGD

PMID:19124542 PMID:16648482

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

protein kinase cGMP-dependent 1

multiple interactions
increases expression
increases activity
decreases activity

EXP

[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]; PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]; VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of PRKG1 protein

PMID:11799084 PMID:16378109 PMID:19542178 PMID:19797176 PMID:26168186

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005

G

protein C receptor

increases expression

EXP

Phenylephrine results in increased expression of PROCR mRNA

NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989

G

phosphoserine phosphatase

increases expression

EXP

Phenylephrine results in increased expression of PSPH mRNA

NCBI chr12:32,527,091...32,541,182
Ensembl chr12:32,519,269...32,541,180

G

prostaglandin I2 synthase

increases expression

EXP

Phenylephrine results in increased expression of PTGIS mRNA

NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650

G

prostaglandin-endoperoxide synthase 1

multiple interactions
affects response to substance

ISO

FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP

Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]

PMID:17244722 PMID:18701451

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone-like hormone

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of PTHLH mRNA; Phenylephrine results in increased expression of PTHLH protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

protein tyrosine phosphatase, receptor type, F

decreases expression

EXP

Phenylephrine results in decreased expression of PTPRF mRNA

NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426

G

protein tyrosine phosphatase, receptor type, K

decreases expression

EXP

Phenylephrine results in decreased expression of PTPRK mRNA

NCBI chr 1:18,557,091...19,056,297
Ensembl chr 1:18,558,365...19,056,107

G

PVR cell adhesion molecule

increases expression

EXP

Phenylephrine results in increased expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630

G

PYD and CARD domain containing

decreases expression

EXP

Phenylephrine results in decreased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

glycogen phosphorylase L

multiple interactions
increases expression

EXP

[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein; Glucose inhibits the reaction [[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein]
Phenylephrine results in increased expression of PYGL mRNA

PMID:747652 PMID:18158353

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB3B, member RAS oncogene family

decreases expression

EXP

Phenylephrine results in decreased expression of RAB3B mRNA

NCBI chr 5:128,859,034...128,926,087
Ensembl chr 5:128,841,716...128,926,086

G

Rac family small GTPase 1

increases activity

EXP

Phenylephrine results in increased activity of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases phosphorylation

EXP

Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of RAF1 protein]

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

retinoic acid induced 14

increases expression

EXP

Phenylephrine results in increased expression of RAI14 mRNA

NCBI chr 2:61,273,439...61,411,141
Ensembl chr 2:61,273,439...61,409,791

G

receptor activity modifying protein 1

affects expression

EXP

Phenylephrine affects the expression of RAMP1 mRNA

NCBI chr 9:99,213,031...99,263,696

G

receptor activity modifying protein 2

multiple interactions
increases expression
decreases expression

EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA
Phenylephrine results in increased expression of RAMP2 mRNA
Phenylephrine results in decreased expression of RAMP2 mRNA

PMID:12899678 PMID:17250927

NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,688,703...86,691,231

G

receptor activity modifying protein 3

increases expression

EXP

Phenylephrine results in increased expression of RAMP3 mRNA

NCBI chr14:85,741,314...85,758,813
Ensembl chr14:85,755,211...85,758,818

G

RAN binding protein 1

multiple interactions

EXP

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; Phenylephrine affects the localization of and affects the expression of RANBP1 protein; trichostatin A inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]

NCBI chr11:96,246,912...96,255,145
Ensembl chr11:96,246,740...96,255,145

G

Rap guanine nucleotide exchange factor 4

increases expression

EXP

Phenylephrine results in increased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

receptor-associated protein of the synapse

decreases expression

EXP

Phenylephrine results in decreased expression of RAPSN mRNA

NCBI chr 3:97,470,891...97,480,196
Ensembl chr 3:97,470,881...97,480,196

G

RASD family, member 2

decreases expression

EXP

Phenylephrine results in decreased expression of RASD2 mRNA

NCBI chr19:13,600,028...13,610,753
Ensembl chr19:13,599,986...13,610,753

G

Ras association domain family member 1

decreases response to substance

ISO
EXP

RASSF1 protein results in decreased susceptibility to Phenylephrine

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

RB transcriptional corepressor 1

increases expression
affects phosphorylation

EXP

Phenylephrine results in increased expression of RB1 protein
Phenylephrine affects the phosphorylation of RB1 protein

PMID:15603588 PMID:18084315

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RANBP2-type and C3HC4-type zinc finger containing 1

multiple interactions
affects response to substance

EXP

Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; Phenylephrine results in increased phosphorylation of and results in increased expression of RBCK1 protein; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]
RBCK1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:161,249,390...161,266,032

G

RNA binding fox-1 homolog 2

EXP

Phenylephrine increases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells

RGD

NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:110,691,230...110,934,987

G

regulator of calcineurin 1

increases expression
multiple interactions

ISO
EXP

Phenylephrine results in increased expression of RCAN1 protein
Phenylephrine results in increased expression of RCAN1 mRNA
MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]

PMID:18025526 PMID:25358972

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
affects localization

EXP

[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]
Phenylephrine affects the localization of RELA protein

PMID:11381115 PMID:18701451

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

renin

decreases activity
affects response to substance

ISO

Phenylephrine results in decreased activity of REN protein
REN1 protein affects the susceptibility to Phenylephrine

PMID:2847676 PMID:17679040

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

REV3 like, DNA directed polymerase zeta catalytic subunit

decreases expression

EXP

Phenylephrine results in decreased expression of REV3L mRNA

NCBI chr20:44,686,482...44,844,668
Ensembl chr20:44,686,940...44,844,668

G

regulator of G-protein signaling 2

multiple interactions
increases expression
affects response to substance

EXP
ISO

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
RGS2 protein affects the susceptibility to Phenylephrine

PMID:15452191 PMID:16517124 PMID:17644703 PMID:18158353

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

regulator of G-protein signaling 3

multiple interactions

ISO

RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 5:81,037,588...81,177,446
Ensembl chr 5:81,056,068...81,177,445

G

regulator of G-protein signaling 4

multiple interactions

ISO

RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

ras homolog family member A

multiple interactions
increases activity

EXP

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; monomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]

PMID:10843871 PMID:15081308 PMID:21708234 PMID:24449418 PMID:25449040

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

receptor interacting serine/threonine kinase 1

increases expression

ISO

Phenylephrine results in increased expression of RIPK1 protein

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 3

increases expression

ISO

Phenylephrine results in increased expression of RIPK3 protein

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

Rho family GTPase 1

increases expression

EXP

Phenylephrine results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

ring finger protein 39

increases expression

EXP

Phenylephrine results in increased expression of RNF39 mRNA

NCBI chr20:1,610,027...1,615,516
Ensembl chr20:1,610,026...1,612,323

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

EXP

Phenylephrine results in increased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

ribosomal protein S6 kinase A5

multiple interactions

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]

PMID:15522277 PMID:19002563

NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

EXP

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]

PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 PMID:15795328 More...

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ribosomal protein S6 kinase B2

multiple interactions

EXP

bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]

NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:210,880,825...210,887,562

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

decreases expression

EXP

Phenylephrine results in decreased expression of RRAD protein

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

RUNX1 partner transcriptional co-repressor 1

decreases expression

EXP

Phenylephrine results in decreased expression of RUNX1T1 mRNA

NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:31,984,855...32,132,855

G

S100 calcium binding protein A6

multiple interactions

EXP

S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]

NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762

G

S100 calcium binding protein B

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of S100B mRNA
S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

sterol-C5-desaturase

increases expression

EXP

Phenylephrine results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

stearoyl-Coenzyme A desaturase 2

increases expression

EXP

Phenylephrine results in increased expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

selenium binding protein 1

decreases expression

EXP

Phenylephrine results in decreased expression of SELENBP1 mRNA

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:185,183,004...185,194,295

G

semaphorin 6D

decreases expression

EXP

Phenylephrine results in decreased expression of SEMA6D mRNA

NCBI chr 3:131,801,680...132,394,578
Ensembl chr 3:132,337,343...132,394,584

G

septin 5

increases expression

EXP

Phenylephrine results in increased expression of SEPTIN5 mRNA

NCBI chr11:95,877,946...95,883,738
Ensembl chr11:95,873,864...95,883,737

G

serpin family E member 1

increases expression

ISO
EXP

Phenylephrine results in increased expression of SERPINE1 mRNA

PMID:15808835 PMID:15850565

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serum/glucocorticoid regulated kinase 1

increases phosphorylation
multiple interactions

EXP

Phenylephrine results in increased phosphorylation of SGK1 protein
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]

PMID:15795328 PMID:16533503

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

salt-inducible kinase 1

increases expression

EXP

Phenylephrine results in increased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

sirtuin 6

multiple interactions

EXP

[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542

G

solute carrier family 12 member 2

multiple interactions

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of SLC12A2 protein]; Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470

G

solute carrier family 16 member 10

decreases expression

EXP

Phenylephrine results in decreased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 16 member 3

increases expression

EXP

Phenylephrine results in increased expression of SLC16A3 mRNA

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 16 member 7

decreases expression

EXP

Phenylephrine results in decreased expression of SLC16A7 mRNA

NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:62,936,567...63,040,386

G

solute carrier family 1 member 3

increases expression

EXP

Phenylephrine results in increased expression of SLC1A3 mRNA

NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:59,482,709...59,557,808

G

solute carrier family 22 member 1

multiple interactions

EXP

[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 3

multiple interactions

EXP

[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 26 member 6

decreases activity
increases expression

EXP

Phenylephrine results in decreased activity of SLC26A6 protein
Phenylephrine results in increased expression of SLC26A6 protein

NCBI chr 8:118,438,110...118,448,271
Ensembl chr 8:118,438,180...118,448,270

G

solute carrier family 29 member 1

increases expression

EXP

Phenylephrine results in increased expression of SLC29A1 mRNA

NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620

G

solute carrier family 2 member 1

increases expression

EXP

Phenylephrine results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 4 member 1 adaptor protein

decreases expression

EXP

Phenylephrine results in decreased expression of SLC4A1AP mRNA

NCBI chr 6:30,625,931...30,653,859
Ensembl chr 6:30,625,931...30,653,792

G

solute carrier family 4 member 3

increases activity

EXP

Phenylephrine results in increased activity of SLC4A3 protein

NCBI chr 9:84,484,749...84,497,746
Ensembl chr 9:84,485,085...84,497,738

G

solute carrier family 7 member 1

increases expression

EXP

Phenylephrine results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030

G

solute carrier family 8 member A1

multiple interactions
increases expression
decreases expression

ISO
EXP

EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]
Phenylephrine results in increased expression of SLC8A1 mRNA
Phenylephrine results in decreased expression of SLC8A1 protein

PMID:11179087 PMID:15621046 PMID:19244478

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964

G

solute carrier family 9 member A1

multiple interactions
increases expression
increases activity

EXP

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of SLC9A1 mRNA; Phenylephrine results in increased expression of SLC9A1 protein

PMID:15452191 PMID:16236312 PMID:16513848 PMID:16517124

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

SMAD family member 2

multiple interactions

EXP

Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SPARC related modular calcium binding 2

decreases expression

EXP

Phenylephrine results in decreased expression of SMOC2 mRNA

NCBI chr 1:63,935,627...64,064,952
Ensembl chr 1:63,935,647...64,064,955

G

submaxillary gland androgen regulated protein 3B

multiple interactions

EXP

SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]

NCBI chr14:20,067,850...20,072,520
Ensembl chr14:20,067,851...20,072,527

G

sorbitol dehydrogenase

decreases expression

EXP

Phenylephrine results in decreased expression of SORD mRNA

NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100

G

SRY-box transcription factor 2

multiple interactions

EXP

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

SRY-box transcription factor 6

decreases expression

EXP

Phenylephrine results in decreased expression of SOX6 mRNA

NCBI chr 1:179,157,678...179,769,243
Ensembl chr 1:179,163,566...179,711,727

G

Sp1 transcription factor

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

secreted phosphoprotein 1

increases expression

EXP

Phenylephrine results in increased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sprouty RTK signaling antagonist 1

increases expression

EXP

Phenylephrine results in increased expression of SPRY1 mRNA

NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956

G

spectrin, alpha, erythrocytic 1

decreases expression

EXP

Phenylephrine results in decreased expression of SPTA1 mRNA

NCBI chr13:88,735,833...88,811,697
Ensembl chr13:88,735,833...88,811,697

G

squalene epoxidase

increases expression

EXP

Phenylephrine results in increased expression of SQLE mRNA

NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050

G

sequestosome 1

decreases expression

EXP

Phenylephrine results in decreased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

increases expression

EXP

Phenylephrine results in increased expression of ST3GAL2 mRNA

NCBI chr19:55,798,112...55,849,226
Ensembl chr19:55,799,471...55,849,225

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

increases expression

EXP

Phenylephrine results in increased expression of ST3GAL4 mRNA

NCBI chr 8:41,673,510...41,723,158
Ensembl chr 8:41,673,510...41,712,551

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

increases expression

EXP

Phenylephrine results in increased expression of ST8SIA5 mRNA

NCBI chr18:73,010,235...73,072,984
Ensembl chr18:73,011,383...73,072,991

G

signal transducer and activator of transcription 1

decreases expression

EXP

Phenylephrine results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

affects localization
increases expression
multiple interactions

EXP

Phenylephrine affects the localization of STAT3 protein
Phenylephrine results in increased expression of STAT3
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]

PMID:19299911 PMID:27094369

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stanniocalcin 1

affects expression

EXP

Phenylephrine affects the expression of STC1 mRNA

NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082

G

stathmin 1

decreases expression

EXP

Phenylephrine results in decreased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

syntaxin 11

affects expression

EXP

Phenylephrine affects the expression of STX11 mRNA

NCBI chr 1:9,111,216...9,140,227
Ensembl chr 1:9,107,796...9,178,455

G

tachykinin, precursor 1

multiple interactions
increases secretion
affects response to substance

EXP

alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein]
TAC1 protein affects the susceptibility to Phenylephrine

PMID:11270094 PMID:17240043

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

tachykinin receptor 1

increases response to substance

EXP

TACR1 protein results in increased susceptibility to Phenylephrine

NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492

G

TATA-box binding protein associated factor 1

increases expression

EXP

Phenylephrine results in increased expression of TAF1 mRNA

NCBI chr X:70,680,901...70,756,535
Ensembl chr X:70,680,906...70,756,735

G

t-complex-associated testis expressed 1

decreases expression

EXP

Phenylephrine results in decreased expression of TCTE1 mRNA

NCBI chr 9:22,961,005...22,979,711
Ensembl chr 9:22,961,176...22,970,391

G

transcription factor Dp-1

increases expression

EXP

Phenylephrine results in increased expression of TFDP1 protein

NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996

G

transforming growth factor, beta 1

increases expression

ISO
EXP

Phenylephrine results in increased expression of TGFB1 mRNA
Phenylephrine results in increased expression of TGFB1 mRNA; Phenylephrine results in increased expression of TGFB1 protein

PMID:10406839 PMID:11821714 PMID:19443575

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor beta 1 induced transcript 1

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of TGFB1I1 protein
[Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 1:192,258,992...192,265,903
Ensembl chr 1:192,258,598...192,265,903

G

transforming growth factor, beta 2

increases expression

EXP

Phenylephrine results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

increases expression

EXP

Phenylephrine results in increased expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transforming growth factor, beta receptor 1

increases expression

EXP

Phenylephrine results in increased expression of TGFBR1 mRNA

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

transforming growth factor, beta receptor 2

increases expression

EXP

Phenylephrine results in increased expression of TGFBR2 mRNA

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469

G

transglutaminase 2

multiple interactions
decreases activity
increases expression

EXP

ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Ethanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]
Phenylephrine results in increased expression of TGM2 mRNA

PMID:10801782 PMID:18158353

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

thyroid hormone receptor alpha

multiple interactions
increases expression

EXP

THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]
Phenylephrine results in increased expression of THRA protein

PMID:11577024 PMID:17389455

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor beta

decreases expression
increases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of THRB mRNA; Phenylephrine results in decreased expression of THRB protein
Phenylephrine results in increased expression of THRB protein
THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]

PMID:11577024 PMID:17389455

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

EXP

BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
Phenylephrine results in increased expression of TIMP1 mRNA; Phenylephrine results in increased expression of TIMP1 protein

PMID:18158353 PMID:19910689

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

transmembrane protein 140

decreases expression

EXP

Phenylephrine results in decreased expression of TMEM140 mRNA

NCBI chr 4:64,503,621...64,514,620
Ensembl chr 4:64,500,439...64,521,990

G

transmembrane protein 176B

decreases expression

EXP

Phenylephrine results in decreased expression of TMEM176B mRNA

NCBI chr 4:79,097,808...79,105,263
Ensembl chr 4:79,097,808...79,105,263

G

transmembrane protein 43

increases expression

EXP

Phenylephrine results in increased expression of TMEM43 mRNA

NCBI chr 4:125,534,844...125,549,986
Ensembl chr 4:125,534,813...125,549,988

G

thymosin beta 15B2

increases expression

EXP

Phenylephrine results in increased expression of TMSB15B2 mRNA

NCBI chr X:105,090,980...105,093,094
Ensembl chr X:105,090,980...105,093,094

G

tumor necrosis factor

decreases secretion
decreases response to substance
increases expression
multiple interactions

EXP

Phenylephrine results in decreased secretion of TNF protein
TNF protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased expression of TNF mRNA; Phenylephrine results in increased expression of TNF protein
Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]

PMID:12423672 PMID:13679239 PMID:16020479 PMID:17872965 PMID:18701451

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

increases expression

ISO

Phenylephrine results in increased expression of TNFAIP3 protein

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 12A

increases expression

EXP

Phenylephrine results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF superfamily member 11

increases expression
multiple interactions

ISO

Phenylephrine results in increased expression of TNFSF11 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

thymocyte selection-associated high mobility group box

decreases expression

EXP

Phenylephrine results in decreased expression of TOX mRNA

NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:24,672,487...24,968,754

G

tropomyosin 2

increases expression

EXP

Phenylephrine results in increased expression of TPM2 mRNA

NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726

G

triadin

decreases expression

EXP

Phenylephrine results in decreased expression of TRDN mRNA

NCBI chr 1:25,774,765...26,230,069
Ensembl chr 1:25,774,765...26,229,717

G

tribbles pseudokinase 3

increases expression

EXP

Phenylephrine results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 2

decreases expression

EXP

Phenylephrine results in decreased expression of TRIM2 mRNA

NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:171,798,660...171,913,468

G

tripartite motif-containing 25

decreases expression

EXP

Phenylephrine results in decreased expression of TRIM25 mRNA

NCBI chr10:74,310,024...74,328,473
Ensembl chr10:74,310,022...74,331,716

G

tripartite motif-containing 34

decreases expression

EXP

Phenylephrine results in decreased expression of TRIM34 mRNA

NCBI chr 1:168,119,043...168,130,544
Ensembl chr 1:168,119,074...168,132,059

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

EXP

Phenylephrine results in increased expression of TRPC1 protein

NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:105,142,931...105,193,826

G

transient receptor potential cation channel, subfamily C, member 3

multiple interactions
increases expression

EXP

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]; [Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium; TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]
Phenylephrine results in increased expression of TRPC3 mRNA; Phenylephrine results in increased expression of TRPC3 protein

PMID:15672411 PMID:19244478

NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:121,409,436...121,475,823

G

transient receptor potential cation channel, subfamily C, member 6

multiple interactions

EXP

TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304

G

transient receptor potential cation channel, subfamily M, member 8

multiple interactions

EXP

6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenylephrine binds to and results in increased activity of TRPM8 protein

NCBI chr 9:96,315,567...96,437,959
Ensembl chr 9:96,351,681...96,436,617

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

ISO

TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with calcitonin gene-related peptide (8-37)]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

TSC complex subunit 2

multiple interactions
increases phosphorylation

EXP

SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]

PMID:15757502 PMID:15795328

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600

G

tubulin, beta 6 class V

increases expression

EXP

Phenylephrine results in increased expression of TUBB6 mRNA

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

thymidine phosphorylase

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of SCO2 protein
VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003

G

tyrosinase

multiple interactions
increases activity

EXP

Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubinuclein 1

decreases expression

EXP

Phenylephrine results in decreased expression of UBN1 mRNA

NCBI chr10:11,003,036...11,038,466
Ensembl chr10:11,003,036...11,038,466

G

ubiquitin C-terminal hydrolase L1

increases expression

EXP

Phenylephrine results in increased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

urocortin

affects response to substance

EXP

UCN protein affects the susceptibility to Phenylephrine

NCBI chr 6:30,958,086...30,958,916
Ensembl chr 6:30,957,383...30,959,422

G

vascular cell adhesion molecule 1

decreases expression

EXP

Phenylephrine results in decreased expression of VCAM1 mRNA

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

versican

increases expression

EXP

Phenylephrine results in increased expression of VCAN mRNA

NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955

G

vascular endothelial growth factor A

multiple interactions

EXP

VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vimentin

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of VIM protein
VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vasoactive intestinal peptide

affects response to substance

ISO

VIP protein affects the susceptibility to Phenylephrine

NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558

G

WASP like actin nucleation promoting factor

multiple interactions

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]

NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:54,049,082...54,097,570

G

WAP four-disulfide core domain 1

increases expression

EXP

Phenylephrine results in increased expression of WFDC1 mRNA

NCBI chr19:64,628,689...64,647,739
Ensembl chr19:64,607,794...64,648,028

G

Wnt inhibitory factor 1

increases expression

EXP

Phenylephrine results in increased expression of WIF1 mRNA

NCBI chr 7:58,433,326...58,503,853
Ensembl chr 7:58,384,643...58,503,852

G

xenotropic and polytropic retrovirus receptor 1

increases expression

EXP

Phenylephrine results in increased expression of XPR1 mRNA

NCBI chr13:69,991,517...70,136,249
Ensembl chr13:69,996,692...70,136,164

G

zinc finger DHHC-type palmitoyltransferase 2

increases expression

EXP

Phenylephrine results in increased expression of ZDHHC2 mRNA

NCBI chr16:58,511,931...58,581,530
Ensembl chr16:58,511,934...58,581,516

G

zinc finger protein 46

decreases expression

EXP

Phenylephrine results in decreased expression of ZFP46 mRNA

NCBI chr 5:153,802,887...153,813,388
Ensembl chr 5:153,802,834...153,812,941

G

zinc finger protein 503

decreases expression

EXP

Phenylephrine results in decreased expression of ZFP503 mRNA

NCBI chr15:2,362,450...2,366,238
Ensembl chr15:2,362,427...2,366,238

G

zinc finger protein 866

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL5 mRNA

NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,702,297...19,709,330

G

zinc finger protein, multitype 2

decreases response to substance
multiple interactions

ISO
EXP

ZFPM2 protein results in decreased susceptibility to Phenylephrine
ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 7:73,563,732...74,001,041
Ensembl chr 7:73,563,732...74,001,041

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of BDNF protein]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

calcitonin-related polypeptide alpha

multiple interactions
decreases expression

ISO
EXP

Sumatriptan results in decreased expression of and results in decreased secretion of CALCA protein
Sumatriptan results in decreased expression of CALCA mRNA
3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; GR 127935 inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; isamoltane inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]

PMID:12574409 PMID:14715155 PMID:15689192

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

caspase 3

multiple interactions

EXP

Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 22

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]

NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359

G

C-C motif chemokine ligand 3

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine receptor 4

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]

NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642

G

Cd80 molecule

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of CD80 protein]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

ciliogenesis associated kinase 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]

NCBI chr 8:87,868,294...87,922,995
Ensembl chr 8:87,868,156...87,922,995

G

ciliary neurotrophic factor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTF protein]

NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488

G

ciliary neurotrophic factor receptor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]

NCBI chr 5:61,619,326...61,657,359
Ensembl chr 5:61,619,326...61,645,795

G

colony stimulating factor 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

catenin beta 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X3-C motif chemokine ligand 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

C-X-C motif chemokine ligand 10

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine receptor 4

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

ERBB receptor feedback inhibitor 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]

NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432

G

Fas associated via death domain

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FADD protein]

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas cell surface death receptor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FAS protein]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fibroblast growth factor binding protein 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]

NCBI chr14:71,316,171...71,319,965
Ensembl chr14:71,317,065...71,320,309

G

fibrinogen-like 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]

NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

follistatin-like 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]

NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126

G

GDNF family receptor alpha 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]

NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501

G

GDNF family receptor alpha 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782

G

growth hormone 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein]

NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859

G

growth hormone receptor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GHR protein]

NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331

G

hypocretin neuropeptide precursor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of HCRT protein]

NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524

G

5-hydroxytryptamine receptor 1B

multiple interactions
affects binding

EXP

Sumatriptan binds to and results in increased activity of HTR1B protein
Sumatriptan binds to HTR1B protein

PMID:11301495 PMID:11888550

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583

G

5-hydroxytryptamine receptor 1D

multiple interactions

EXP

Sumatriptan binds to and results in increased activity of HTR1D protein

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

G

insulin degrading enzyme

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IDE protein]

NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526

G

interferon gamma

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 13

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 1 alpha

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Sumatriptan inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of IL1B mRNA]

PMID:22150557 PMID:29958920

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL2 protein]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 3

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein]

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810

G

interleukin 4

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibin subunit beta A

multiple interactions

EXP

Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INHBA protein]

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

insulin 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

leptin

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein]

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

mitogen activated protein kinase kinase 1

multiple interactions

EXP

[Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]; Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

macrophage migration inhibitory factor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein]

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

matrix metallopeptidase 13

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

muscle associated receptor tyrosine kinase

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MUSK protein]

NCBI chr 5:77,853,560...77,967,653
Ensembl chr 5:77,853,736...77,964,338

G

nerve growth factor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]

PMID:12574409 PMID:22150557

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nerve growth factor receptor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein]

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

nitric oxide synthase 1

multiple interactions

EXP

Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

ISO

Sumatriptan results in decreased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

neuropilin 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

platelet derived growth factor subunit A

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]

NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322

G

perilipin 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

proopiomelanocortin

decreases expression
multiple interactions

ISO
EXP

Sumatriptan results in decreased expression of POMC protein modified form
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]

PMID:7640145 PMID:22150557

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

prolactin receptor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of PRLR protein]

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

prokineticin 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]

NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:197,537,068...197,547,550

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

Sumatriptan inhibits the reaction [Vincristine results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

resistin

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETN protein]

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116

G

resistin like beta

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]

NCBI chr11:65,446,433...65,448,319
Ensembl chr11:65,446,434...65,448,319

G

selectin E

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

selectin L

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELL protein]

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

secreted phosphoprotein 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Sumatriptan promotes the reaction [Capsaicin results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

TAL bHLH transcription factor 1, erythroid differentiation factor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]

NCBI chr 5:133,823,093...133,837,737
Ensembl chr 5:133,826,003...133,837,738

G

TEK receptor tyrosine kinase

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TEK protein]

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

transforming growth factor, beta 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

TIMP metallopeptidase inhibitor 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

TIMP metallopeptidase inhibitor 3

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

toll-like receptor 4

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of TNF mRNA]

PMID:22150557 PMID:29958920

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 19

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Sumatriptan inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]

NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438

G

TNF superfamily member 10

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]

NCBI chr 2:112,136,550...112,155,903

G

vascular cell adhesion molecule 1

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor A

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Sumatriptan affects the reaction [Capsaicin results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

zinc finger protein 866

multiple interactions

EXP

[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]

NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,702,297...19,709,330

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

eukaryotic translation elongation factor 2

multiple interactions

ISO

U0126 inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells]

RGD

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544

G

glutamate ionotropic receptor AMPA type subunit 1

multiple interactions

EXP

U0126 inhibits the reaction [BDNF increases expression of Gria1 protein on nucleus accumbens medium spiny neurons]
U0126 inhibits the reaction [Morphine increases localization of Gria1 protein on shell of nucleus accumbens cell surface]

RGD

PMID:24712995 PMID:25746394

RGD:405650624, RGD:11087075

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309

G

glutamate ionotropic receptor AMPA type subunit 2

multiple interactions

EXP

U0126 inhibits the reaction [BDNF increases expression of Gria2 protein on nucleus accumbens medium spiny neurons]

RGD

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616

G

mitogen activated protein kinase 1

decreases reaction

EXP

U0126 inhibits the reaction [estrogen increases phosphorylation of Mapk1/3 protein] in rat uterus

RGD

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases reaction

EXP

U0126 inhibits the reaction [estrogen increases phosphorylation of Mapk1/3 protein] in rat uterus

RGD

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

U0126 inhibits the reaction [17alpha-ethynylestradiol increases phosphorylation of Prkaa1 in primary hepatocytes]

RGD

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2-associated agonist of cell death

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAD protein]

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 mRNA]; zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

zolmitriptan results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

glutamic--pyruvic transaminase

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

nitric oxide synthase 2

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

EXP

zolmitriptan inhibits the reaction [Diethylnitrosamine results in decreased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

synuclein alpha

multiple interactions

EXP

Dextromethorphan promotes the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]; Glutamic Acid inhibits the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]; zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
application	20572
pharmaceutical	20359
drug	20359
cardiovascular drug	8214
vasoconstrictor agent	2051
(-)-ephedrine	28
(8S,9R)-EET	0
(R)-adrenaline +	112
(R)-noradrenaline	193
8-epi-prostaglandin E2	1
8-epi-prostaglandin F2alpha	6
FE201874	0
P(1),P(5)-bis(5'-adenosyl) pentaphosphate	3
P(1),P(6)-bis(5'-adenosyl)hexaphosphate	1
PD123319	30
U0126 +	6
U0126.EtOH	0
almotriptan +	9
almotriptan malate	0
alpha-methylnoradrenaline	0
angiotensin II +	50
caesium chloride	2
carbocyclic thromboxane A2	2
cocaine	1460
deglymidodrine	0
dihydroergotamine +	12
dihydroergotamine mesylate	0
dihydroergotamine tartrate	0
droxidopa	0
eletriptan	4
eletriptan hydrobromide	0
ergotamine	5
felypressin	0
leukotriene B4	39
metaraminol	0
methysergide	5
midodrine	2
midodrine hydrochloride	0
mometasone	0
naratriptan +	2
oxymetazoline	8
oxymetazoline hydrochloride	0
phenylephrine	527
pseudoephedrine	0
rizatriptan	0
sumatriptan	84
sumatriptan succinate	0
tetrahydrozoline hydrochloride	0
tetrahydrozoline nitrate	0
zolmitriptan	11

paths to the root