laxative - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	laxative	go back to main search page
Accession:	CHEBI:50503	browse the term
Definition:	An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic.
Synonyms:	related_synonym:	aperient; aperients; laxante; laxatives; purgative; purgatives

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Rat (284 ) Mouse (282 ) Human (288 ) Chinchilla (0 ) Bonobo (0 ) Dog (2 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (284)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

increases expression
multiple interactions

EXP

Castor Oil results in increased expression of PAFAH1B1 protein
isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein]

PMID:1354728 PMID:2743081 PMID:8738301

NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B1

multiple interactions
increases abundance

ISO

AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]
AKR1B1 protein results in increased abundance of Sorbitol

PMID:25451566 PMID:25541468

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

arachidonate 5-lipoxygenase

multiple interactions

ISO

[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein

PMID:10779545 PMID:11698504

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

aquaporin 9

multiple interactions
increases uptake

ISO
EXP

Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]
AQP9 protein results in increased uptake of Sorbitol

PMID:9733774 PMID:19341753

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

bolA family member 2

increases expression

ISO

Sorbitol results in increased expression of BOLA2 mRNA

NCBI chr 1:190,722,535...190,723,401
Ensembl chr 8:64,800,454...64,800,714
Ensembl chr 1:64,800,454...64,800,714

G

cell cycle associated protein 1

multiple interactions

ISO

Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein]

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

caspase 3

increases activity
multiple interactions

EXP

Sorbitol results in increased activity of CASP3 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity
multiple interactions

EXP

Sorbitol results in increased activity of CASP8 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity
multiple interactions

EXP

Sorbitol results in increased activity of CASP9 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

cyclin A1

decreases expression

ISO

Sorbitol results in decreased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin F

increases expression

ISO

Sorbitol results in increased expression of CCNF mRNA

NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,758,421...13,783,837

G

cyclin-dependent kinase 1

decreases expression

ISO

Sorbitol results in decreased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

choline kinase beta

decreases expression

ISO

Sorbitol results in decreased expression of CHKB mRNA

NCBI chr 7:122,380,592...122,385,102
Ensembl chr 7:122,380,594...122,383,949

G

CRK proto-oncogene, adaptor protein

increases phosphorylation

EXP

Sorbitol results in increased phosphorylation of CRK protein

NCBI chr10:61,028,736...61,054,971
Ensembl chr10:61,028,757...61,082,988

G

damage-specific DNA binding protein 1

increases expression

ISO

Sorbitol results in increased expression of DDB1 mRNA

NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:216,677,810...216,703,596

G

eukaryotic translation elongation factor 1 delta

increases expression

ISO

Sorbitol results in increased expression of EEF1D mRNA

NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:109,462,646...109,489,531

G

eukaryotic translation initiation factor 3, subunit H

decreases expression

ISO

Sorbitol results in decreased expression of EIF3H mRNA

NCBI chr 7:84,980,891...85,064,284
Ensembl chr 7:84,980,891...85,071,546

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

ISO

Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

ENY2, transcription and export complex 2 subunit

increases expression

ISO

Sorbitol results in increased expression of ENY2 mRNA

NCBI chr 7:77,465,885...77,489,637
Ensembl chr 7:77,466,119...77,491,057

G

fragile X messenger ribonucleoprotein 1

increases abundance

ISO

FMR1 5' UTR mutant form results in increased abundance of Sorbitol

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675

G

insulin 1

multiple interactions

EXP

Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation

ISO

JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

mitogen activated protein kinase 10

multiple interactions
increases activity

ISO

Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen-activated protein kinase 12

increases phosphorylation

ISO

Sorbitol results in increased phosphorylation of MAPK12 protein

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 14

increases phosphorylation

ISO

Sorbitol results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen-activated protein kinase 7

increases activity

ISO

Sorbitol results in increased activity of MAPK7 protein

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

mitogen-activated protein kinase 8

increases phosphorylation

ISO

Sorbitol results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

increases phosphorylation

ISO

Sorbitol results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MAPK activated protein kinase 2

increases activity
increases phosphorylation
multiple interactions

ISO

Sorbitol results in increased activity of MAPKAPK2 protein
Sorbitol results in increased phosphorylation of MAPKAPK2 protein
SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]

PMID:9545260 PMID:15362974

NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326

G

MAPK interacting serine/threonine kinase 1

increases activity

ISO

Sorbitol results in increased activity of MKNK1 protein

NCBI chr 5:134,554,881...134,594,392
Ensembl chr 5:134,554,943...134,594,393

G

mitochondrial ribosomal protein S16

decreases expression

ISO

Sorbitol results in decreased expression of MRPS16 mRNA

NCBI chr15:3,967,809...3,970,211
Ensembl chr15:3,968,054...3,970,185

G

ornithine aminotransferase

multiple interactions

EXP

Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

palmitoyl-protein thioesterase 1

increases expression

ISO

Sorbitol results in increased expression of PPT1 mRNA

NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200

G

phosphatase and tensin homolog

affects localization

ISO
EXP

Sorbitol affects the localization of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

ribosomal protein L18

increases expression

ISO

Sorbitol results in increased expression of RPL18 mRNA

NCBI chr 1:105,325,269...105,327,911
Ensembl chr 1:105,325,250...105,327,910

G

small nuclear ribonucleoprotein U5 subunit 200

multiple interactions

ISO

Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein]

NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500

G

sorbitol dehydrogenase

multiple interactions
increases abundance
increases metabolic processing

ISO

[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]

NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100

G

TAR DNA binding protein

increases ubiquitination

ISO

Sorbitol results in increased ubiquitination of TARDBP protein

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

thymidine kinase 1

increases expression

ISO

Sorbitol results in increased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228

G

ubiquitin-conjugating enzyme E2C

decreases expression

ISO

Sorbitol results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

UBX domain protein 1

increases phosphorylation

ISO

Sorbitol results in increased phosphorylation of UBXN1 protein

NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:215,174,216...215,198,343

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression
multiple interactions
affects activity
decreases expression

EXP
ISO

Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside affects the reaction [[Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid]; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCB11 protein; [Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

ISO
EXP

Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]

PMID:19549930 PMID:24380838

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

increases expression

EXP

Emodin results in increased expression of ABCB1B mRNA

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily B member 4

decreases expression

EXP

Emodin results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions
decreases expression

EXP
ISO

Emodin results in increased expression of ABCC2 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 protein
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein

PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions
decreases expression

EXP
ISO

Emodin results in increased expression of ABCC3 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 protein
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein

PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

decreases expression
multiple interactions

EXP
ISO

Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 6

increases expression

EXP

Emodin results in increased expression of ABCC6 mRNA

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895

G

actin, alpha 1, skeletal muscle

decreases expression

ISO

Emodin results in decreased expression of ACTA1 mRNA

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

EXP

Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

PMID:15288473 PMID:27989784

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adhesion G protein-coupled receptor E1

multiple interactions

ISO

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

adrenoceptor beta 2

multiple interactions

ISO

Emodin inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

angiotensinogen

multiple interactions

EXP

Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

aryl hydrocarbon receptor

multiple interactions

ISO

Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

PMID:14644660 PMID:17869316

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1 member B10

decreases activity

ISO

Emodin results in decreased activity of AKR1B10 protein

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C3

decreases activity

ISO

Emodin results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

aldo-keto reductase family 7 member A3

decreases activity

ISO

Emodin results in decreased activity of AKR7A3 protein

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
decreases expression

ISO
EXP

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA

PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

decreases phosphorylation
multiple interactions

ISO
EXP

Emodin results in decreased phosphorylation of AKT2 protein
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

AKT serine/threonine kinase 3

decreases phosphorylation
multiple interactions

ISO
EXP

Emodin results in decreased phosphorylation of AKT3 protein
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT3 protein]

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020

G

androgen receptor

multiple interactions

ISO

Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

arginase 2

decreases expression

ISO

Emodin results in decreased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375

G

AT-rich interaction domain 3A

increases expression

ISO

Emodin results in increased expression of ARID3A mRNA

NCBI chr 7:10,403,161...10,431,551
Ensembl chr 7:10,405,631...10,427,926

G

ATM serine/threonine kinase

increases expression
increases phosphorylation

ISO

Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein

PMID:16045814 PMID:20855424

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

BAG cochaperone 5

decreases expression

ISO

Emodin results in decreased expression of BAG5 mRNA

NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:136,584,741...136,598,492

G

BCL2 associated X, apoptosis regulator

affects expression
increases expression
multiple interactions
decreases expression

ISO
EXP

Emodin affects the expression of BAX protein
Emodin results in increased expression of BAX protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein]
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]

PMID:19549930 PMID:27032576 PMID:35753641

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
affects expression

ISO
EXP

Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]

PMID:19549930 PMID:23848338 PMID:27032576 PMID:35753641

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bifunctional apoptosis regulator

decreases expression

ISO

Emodin results in decreased expression of BFAR mRNA

NCBI chr10:2,059,189...2,092,207
Ensembl chr10:2,059,058...2,094,183

G

BH3 interacting domain death agonist

increases degradation
multiple interactions

ISO

Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

calnexin

decreases expression

ISO

Emodin results in decreased expression of CANX mRNA

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 1

increases expression
multiple interactions

ISO

Emodin results in increased expression of CASP1 mRNA
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

PMID:15612046 PMID:37023836

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

decreases expression

ISO

Emodin results in decreased expression of CASP12 mRNA

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases expression
multiple interactions
affects expression
increases cleavage
increases activity

ISO
EXP

Emodin results in increased expression of CASP3 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP3 protein; Emodin inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]

PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 PMID:34492313 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions
increases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases expression
multiple interactions

ISO
EXP

Emodin results in increased expression of CASP9 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP9 protein

PMID:21319176 PMID:35753641

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
affects expression

ISO
EXP

Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein

PMID:19549930 PMID:22271272 PMID:26139382

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carbonyl reductase 1

decreases activity

ISO

Emodin results in decreased activity of CBR1 protein

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

C-C motif chemokine ligand 26

multiple interactions

ISO

Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]

NCBI chr12:26,745,972...26,750,924

G

cyclin B2

decreases expression

ISO

Emodin results in decreased expression of CCNB2 mRNA

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

C-C motif chemokine receptor 3

multiple interactions

ISO

Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]

NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593

G

cadherin 1

increases expression
multiple interactions

EXP

Emodin results in increased expression of CDH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase 13

decreases expression

ISO

Emodin results in decreased expression of CDK13 mRNA

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257

G

cyclin-dependent kinase 4

decreases expression

ISO

Emodin results in decreased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1C

increases expression

ISO

Emodin results in increased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498

G

cadherin, EGF LAG seven-pass G-type receptor 3

decreases expression

ISO

Emodin results in decreased expression of CELSR3 mRNA

NCBI chr 8:118,409,136...118,438,593
Ensembl chr 8:118,409,136...118,436,847

G

chitinase, acidic

multiple interactions

ISO

Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA]

NCBI chr 2:196,302,687...196,344,849
Ensembl chr 2:196,302,545...196,344,850

G

cell death-inducing DFFA-like effector c

decreases expression

ISO

Emodin results in decreased expression of CIDEC mRNA

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806

G

collagen type I alpha 1 chain

decreases expression

EXP

Emodin results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

multiple interactions

EXP

Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type III alpha 1 chain

decreases expression

EXP

Emodin results in decreased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

COP9 signalosome subunit 5

multiple interactions

ISO

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein

NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:13,975,052...13,993,387

G

casein kinase 2 alpha 1

increases expression

ISO

Emodin results in increased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

casein kinase 2 beta

increases expression

ISO

Emodin results in increased expression of CSNK2B mRNA

NCBI chr20:3,704,833...3,709,999
Ensembl chr20:3,704,904...3,710,525

G

cathepsin D

decreases expression

ISO

Emodin results in decreased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

C-X-C motif chemokine ligand 1

multiple interactions

EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 2

multiple interactions

EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

CYLD lysine 63 deubiquitinase

increases expression

ISO

Emodin results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases expression

ISO

Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein

PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases hydroxylation
increases oxidation
decreases activity

ISO

[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP1A2 protein results in increased hydroxylation of Emodin
CYP1A2 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:27989148 PMID:30672276 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
decreases activity

ISO

Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein

PMID:11502733 PMID:14990334 PMID:27633141

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
multiple interactions

EXP
ISO

Emodin results in decreased expression of CYP27A1 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP27A1 protein

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases oxidation
decreases activity
multiple interactions

ISO

CYP2C19 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP2C19 protein
[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite

PMID:27989148 PMID:33438235

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

ISO

Emodin results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity
affects response to substance
increases hydroxylation
increases oxidation

ISO

[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
Emodin results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the susceptibility to Emodin
CYP3A4 protein results in increased hydroxylation of Emodin
CYP3A4 protein results in increased oxidation of Emodin

PMID:27989148 PMID:30672276 PMID:33438235 PMID:34875353

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases hydroxylation

ISO

CYP3A5 protein results in increased hydroxylation of Emodin

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

EXP

Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 protein

PMID:28161596 PMID:35753641

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

ISO

Emodin results in decreased expression of CYP7B1 mRNA

NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

EXP

Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

dopachrome tautomerase

decreases expression

ISO

Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029

G

DNA-damage inducible transcript 3

increases expression

EXP

Emodin results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dihydrofolate reductase

decreases expression

ISO

Emodin results in decreased expression of DHFR mRNA

NCBI chr 2:25,320,895...25,346,004

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

ISO

Emodin results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

dynein cytoplasmic 1 heavy chain 1

increases expression

ISO

Emodin results in increased expression of DYNC1H1 mRNA

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116

G

E2F transcription factor 5

increases expression

ISO

Emodin results in increased expression of E2F5 mRNA

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143

G

early growth response 1

multiple interactions

EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

EI24, autophagy associated transmembrane protein

increases expression

ISO

Emodin results in increased expression of EI24 mRNA

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:44,683,144...44,695,214

G

eukaryotic translation initiation factor 2B subunit alpha

decreases expression

ISO

Emodin results in decreased expression of EIF2B1 mRNA

NCBI chr12:37,686,149...37,694,830
Ensembl chr12:37,686,559...37,708,078

G

estrogen receptor 1

increases activity

ISO

Emodin results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

increases activity

ISO

Emodin results in increased activity of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

fatty acid binding protein 5

decreases expression

ISO

Emodin results in decreased expression of FABP5 mRNA

NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127

G

Fas associated via death domain

increases expression

ISO

Emodin results in increased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas cell surface death receptor

multiple interactions
decreases expression
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein

PMID:19549930 PMID:27032576

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fibronectin 1

decreases expression

EXP

Emodin results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

forkhead box O1

increases expression

ISO

Emodin results in increased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

ISO

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA]

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest-specific 2

increases expression

ISO

Emodin results in increased expression of GAS2 mRNA

NCBI chr 1:110,587,952...110,721,572
Ensembl chr 1:110,717,312...110,718,541

G

glutamate-cysteine ligase, catalytic subunit

increases expression

EXP

Emodin results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression

EXP

Emodin results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glucosaminyl (N-acetyl) transferase 2

increases expression

ISO

Emodin results in increased expression of GCNT2 mRNA

NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989

G

glial fibrillary acidic protein

multiple interactions

EXP

Emodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

golgin A3

increases expression

ISO

Emodin results in increased expression of GOLGA3 mRNA

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

PMID:34492313 PMID:37023836

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases expression

ISO

Emodin results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions

ISO

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA]

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 4

decreases expression
multiple interactions

ISO
EXP

Emodin results in decreased expression of GPX4 mRNA; Emodin results in decreased expression of GPX4 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 protein]

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutathione-disulfide reductase

multiple interactions

ISO

Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase, mu 5

decreases expression

ISO

Emodin results in decreased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase pi 1

multiple interactions

ISO

Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

H2A.X variant histone

increases expression
multiple interactions

ISO

Emodin results in increased expression of H2AX protein; Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]

PMID:20855424 PMID:34492313 PMID:36893906

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

3-hydroxyacyl-CoA dehydratase 3

decreases expression

ISO

Emodin results in decreased expression of HACD3 mRNA

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700

G

hydroxycarboxylic acid receptor 2

multiple interactions

ISO

Emodin inhibits the reaction [Niacin results in increased activity of HCAR2 protein]

NCBI chr12:38,387,163...38,389,149
Ensembl chr12:38,387,230...38,389,391

G

hes family bHLH transcription factor 1

decreases expression
multiple interactions

ISO
EXP

Emodin results in decreased expression of HES1 mRNA; Emodin results in decreased expression of HES1 protein
JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 protein]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

histone linker H1 domain, spermatid-specific 1

increases expression

ISO

Emodin results in increased expression of H1F9 mRNA

NCBI chr10:80,410,361...80,411,157
Ensembl chr10:80,399,812...80,411,157

G

hexokinase 2

increases expression

ISO

Emodin results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression

ISO
EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein]
Emodin results in decreased expression of HMOX1 mRNA; Emodin results in decreased expression of HMOX1 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]
Emodin results in increased expression of HMOX1 mRNA

PMID:26139382 PMID:30517764 PMID:34875353 PMID:37393915

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hepatocyte nuclear factor 4, alpha

decreases expression
affects glucuronidation

EXP
ISO

Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein
HNF4A gene SNP affects the glucuronidation of Emodin

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

histamine receptor H 1

multiple interactions

ISO

Emodin inhibits the reaction [Histamine results in increased activity of HRH1 protein]

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

heat shock protein family A (Hsp70) member 5

increases expression

EXP

Emodin results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

multiple interactions

EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

immunoglobulin superfamily, member 11

increases expression

ISO

Emodin results in increased expression of IGSF11 mRNA

NCBI chr11:75,238,706...75,389,748
Ensembl chr11:75,236,545...75,390,425

G

interleukin 10

multiple interactions

ISO

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 13

multiple interactions

ISO

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 15

increases expression

ISO

Emodin results in increased expression of IL15 mRNA

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 18

multiple interactions

ISO

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions

ISO
EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein]
Emodin inhibits the reaction [Oxaliplatin results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]

PMID:26139382 PMID:30517764 PMID:36184831 PMID:37023836

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

multiple interactions

ISO

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

multiple interactions

ISO

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions

EXP
ISO

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 PMID:37023836

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

ISO

Emodin results in decreased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

jagged canonical Notch ligand 1

multiple interactions
decreases expression

EXP

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; JAG1 protein inhibits the reaction [Emodin results in increased expression of TP53 protein]
Emodin results in decreased expression of JAG1 protein

PMID:27989784 PMID:37393915

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872

G

Janus kinase 1

decreases phosphorylation
multiple interactions

ISO

Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 2

decreases phosphorylation
multiple interactions

ISO

Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

keratin 19

decreases expression

ISO

Emodin results in decreased expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

lysosomal protein transmembrane 5

increases expression

ISO

Emodin results in increased expression of LAPTM5 mRNA

NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:148,339,435...148,393,927

G

lymphoid enhancer binding factor 1

decreases expression

ISO

Emodin results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

LDL receptor related protein 1

multiple interactions

ISO

[Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein

NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196

G

microtubule-actin crosslinking factor 1

decreases expression

ISO

Emodin results in decreased expression of MACF1 mRNA

NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:140,908,837...141,233,890

G

monoamine oxidase B

decreases activity

EXP

Emodin results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 1

multiple interactions

EXP

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

multiple interactions

EXP

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]

PMID:15288473 PMID:26972667 PMID:27032576

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

increases expression

ISO

Emodin results in increased expression of MAPK10 mRNA

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen activated protein kinase 14

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]

PMID:15288473 PMID:26972667 PMID:27032576

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

microtubule-associated protein tau

decreases expression

ISO

Emodin results in decreased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
increases expression

ISO

Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA

PMID:21319176 PMID:23848338

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

maternal embryonic leucine zipper kinase

decreases expression

ISO

Emodin results in decreased expression of MELK mRNA; Emodin results in decreased expression of MELK protein

NCBI chr 5:63,336,151...63,396,254
Ensembl chr 5:63,336,106...63,396,247

G

O-6-methylguanine-DNA methyltransferase

increases expression

EXP

Emodin results in increased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

melanocyte inducing transcription factor

decreases expression

ISO

Emodin results in decreased expression of MITF protein

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790

G

myeloperoxidase

multiple interactions

EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
affects expression

EXP

Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein

PMID:17886230 PMID:19549930

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin light chain kinase

increases activity

EXP

Emodin results in increased activity of MYLK protein

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659

G

nuclear receptor coactivator 2

increases expression

ISO

Emodin results in increased expression of NCOA2 mRNA

NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression
affects localization

ISO
EXP

Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA]; Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein
Emodin results in decreased expression of NFE2L2 mRNA
Emodin affects the localization of NFE2L2 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]; Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]

PMID:26139382 PMID:34971761 PMID:37393915

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

EXP
ISO

Emodin results in increased expression of NFKB1 protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:19549930 PMID:37023836

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

increases expression
multiple interactions

ISO

Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

PMID:16045814 PMID:22484343

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NK6 homeobox 2

increases expression

ISO

Emodin results in increased expression of NKX6-2 mRNA

NCBI chr 1:203,811,582...203,813,122
Ensembl chr 1:203,811,582...203,813,122

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions
affects expression

EXP

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2

PMID:18590720 PMID:23615023

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

notch receptor 1

decreases expression
multiple interactions
decreases response to substance

EXP
ISO

Emodin results in decreased expression of NOTCH1 protein
Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
NOTCH1 protein results in decreased susceptibility to Emodin

PMID:27989784 PMID:37393915

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

NAD(P)H quinone dehydrogenase 1

increases expression
decreases expression
multiple interactions

ISO
EXP

Emodin results in increased expression of NQO1 mRNA
Emodin results in decreased expression of NQO1 mRNA; Emodin results in decreased expression of NQO1 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; Emodin results in increased expression of and results in increased activity of NQO1 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 protein]

PMID:34875353 PMID:34971761 PMID:37393915

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 0, group B, member 2

increases expression

ISO

Emodin results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group H, member 3

increases expression

ISO

Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

ISO

Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

OMA1 zinc metallopeptidase

multiple interactions

EXP

Emodin inhibits the reaction [Hydrogen Peroxide results in increased expression of OMA1 protein]; Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein]

NCBI chr 5:123,312,038...123,455,540
Ensembl chr 5:123,312,766...123,366,005

G

poly (ADP-ribose) polymerase 1

increases activity
multiple interactions
increases cleavage

ISO

Emodin results in increased activity of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]

PMID:23848338 PMID:27032576 PMID:34492313 PMID:36893906

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

EXP

Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosducin like

decreases expression

ISO

Emodin results in decreased expression of PDCL mRNA

NCBI chr 3:41,519,953...41,529,545
Ensembl chr 3:41,519,954...41,527,794
Ensembl chr 3:41,519,954...41,527,794

G

platelet derived growth factor subunit B

multiple interactions

EXP

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

platelet derived growth factor receptor beta

multiple interactions
decreases expression

EXP

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

platelet and endothelial cell adhesion molecule 1

decreases expression

ISO

Emodin results in decreased expression of PECAM1 protein

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

increases expression

ISO

Emodin results in increased expression of PIK3C3 mRNA

NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539

G

phosphoinositide-3-kinase regulatory subunit 1

affects expression

EXP

Emodin affects the expression of PIK3R1 protein

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

pyruvate kinase M1/2

affects localization
decreases activity
multiple interactions

EXP

Emodin affects the localization of PKM protein
Emodin results in decreased activity of PKM protein
[[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which results in decreased activity of PKM protein; [Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

ISO

Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

ISO

Emodin results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

protein phosphatase 1, regulatory (inhibitor) subunit 1C

decreases expression

ISO

Emodin results in decreased expression of PPP1R1C mRNA

NCBI chr 3:85,023,621...85,126,609
Ensembl chr 3:85,023,621...85,131,413

G

peroxiredoxin 6

increases expression

ISO

Emodin results in increased expression of PRDX6 mRNA

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657

G

protein kinase C, alpha

affects localization

EXP

Emodin affects the localization of PRKCA protein

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, delta

decreases expression
affects expression

ISO
EXP

Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein

PMID:16045814 PMID:19549930

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protamine 3

increases expression

ISO

Emodin results in increased expression of PRM3 mRNA

NCBI chr10:5,384,394...5,384,908

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP
ISO

2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]
Emodin results in increased expression of PTGS2 mRNA; Emodin results in increased expression of PTGS2 protein

PMID:36184831 PMID:37393915

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

affects expression

EXP

Emodin affects the expression of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

protein tyrosine phosphatase, non-receptor type 6

increases expression
multiple interactions

ISO

Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression
multiple interactions

ISO
EXP

Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]

PMID:15288473 PMID:16045814

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

recombination activating 1

decreases expression

ISO

Emodin results in decreased expression of RAG1 mRNA

NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:108,371,978...108,383,261

G

retinoic acid receptor, beta

decreases expression

ISO

Emodin results in decreased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040

G

RB transcriptional corepressor 1

decreases expression

ISO

Emodin results in decreased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

reticulocalbin 2

increases expression

ISO

Emodin results in increased expression of RCN2 mRNA

NCBI chr 8:65,345,247...65,362,290
Ensembl chr 8:65,345,273...65,364,632

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases localization

EXP
ISO

Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of RELA protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]; Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]

PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 PMID:36184831 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ras homolog family member A

decreases expression

ISO

Emodin results in decreased expression of RHOA mRNA

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

ISO

Emodin results in decreased expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

ISO

Emodin results in decreased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

SUMO1 activating enzyme subunit 1

decreases expression

ISO

Emodin results in decreased expression of SAE1 mRNA

NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:86,159,114...86,215,089

G

serpin family E member 1

multiple interactions

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

solute carrier family 10 member 1

decreases expression
multiple interactions

EXP
ISO

Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]

PMID:28161596 PMID:30517764

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier family 22 member 6

decreases activity

ISO

Emodin results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

decreases activity

ISO

Emodin results in decreased activity of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

sperm mitochondria-associated cysteine-rich protein

increases expression

ISO

Emodin results in increased expression of SMCP mRNA

NCBI chr 2:180,856,561...180,861,564

G

small nuclear ribonucleoprotein 13

decreases expression

ISO

Emodin results in decreased expression of SNU13 mRNA

NCBI chr 7:115,445,415...115,451,008
Ensembl chr 1:269,702,002...269,703,004
Ensembl chr 7:269,702,002...269,703,004

G

superoxide dismutase 1

multiple interactions

ISO

Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
affects activity

ISO
EXP

Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein

PMID:21382473 PMID:23615023

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

ISO

Emodin results in decreased phosphorylation of SRC protein

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

increases expression

ISO

Emodin results in increased expression of ST8SIA1 mRNA

NCBI chr 4:177,513,966...177,651,553
Ensembl chr 4:177,520,926...177,651,553

G

signal transducer and activator of transcription 3

affects localization
multiple interactions

ISO

Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stress-induced phosphoprotein 1

decreases expression

ISO

Emodin results in decreased expression of STIP1 mRNA

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

sulfotransferase family 1A member 1

decreases activity

ISO

Emodin results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

SPT20 homolog, SAGA complex component

increases expression

ISO

Emodin results in increased expression of SUPT20H mRNA

NCBI chr 2:141,047,479...141,080,656
Ensembl chr 2:141,047,477...141,081,361

G

TAO kinase 3

decreases expression

ISO

Emodin results in decreased expression of TAOK3 mRNA

NCBI chr12:44,973,180...45,134,439
Ensembl chr12:44,973,180...45,134,439

G

tubulin folding cofactor C

decreases expression

ISO

Emodin results in decreased expression of TBCC mRNA

NCBI chr 9:21,596,472...21,597,660
Ensembl chr 9:21,595,615...21,597,842

G

transcription factor like 5

increases expression

ISO

Emodin results in increased expression of TCFL5 mRNA

NCBI chr 3:188,112,037...188,131,883
Ensembl chr 3:188,112,037...188,131,883

G

transforming growth factor, beta 1

multiple interactions
decreases activity

EXP

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]

PMID:15288473 PMID:19474275 PMID:27989784

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

EXP
ISO

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]

PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 PMID:36184831 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

DNA topoisomerase II alpha

multiple interactions
increases activity

ISO

Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

tumor protein p53

affects expression
multiple interactions
increases expression

EXP
ISO

Emodin affects the expression of TP53 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of TP53 protein]; AKT activator SC79 inhibits the reaction [Emodin results in increased expression of TP53 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of TP53 protein]

PMID:19549930 PMID:37393915

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p63

increases expression

ISO

Emodin results in increased expression of TRP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177

G

Tnf receptor-associated factor 2

increases expression
decreases expression

ISO

Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA

PMID:16045814 PMID:21319176

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

transient receptor potential cation channel, subfamily V, member 2

increases expression

ISO

Emodin results in increased expression of TRPV2 mRNA

NCBI chr10:47,772,223...47,797,956
Ensembl chr10:47,764,839...47,793,533

G

testis specific, 13

increases expression

ISO

Emodin results in increased expression of TSGA13 mRNA

NCBI chr 4:60,469,136...60,490,218
Ensembl chr 4:60,469,136...60,490,173

G

tubulin, beta 3 class III

decreases expression

ISO

Emodin results in decreased expression of TUBB3 mRNA

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

thioredoxin 1

multiple interactions

EXP

Emodin results in increased expression of and results in increased activity of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin-like 4B

decreases expression

ISO

Emodin results in decreased expression of TXNL4B mRNA

NCBI chr19:54,439,686...54,449,777
Ensembl chr19:54,439,680...54,448,052

G

thioredoxin reductase 1

decreases expression
multiple interactions

ISO
EXP

Emodin results in decreased expression of TXNRD1 mRNA
Emodin results in increased expression of and results in increased activity of TXNRD1 protein

PMID:16045814 PMID:34971761

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

tyrosinase

decreases activity

ISO

Emodin results in decreased activity of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

tyrosinase-related protein 1

decreases expression

ISO

Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

ubiquitin-conjugating enzyme E2I

increases expression

ISO

Emodin results in increased expression of UBE2I mRNA

NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

ISO

UGT1A1 protein results in increased glucuronidation of Emodin

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of Emodin

PMID:14557274 PMID:24854283

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

EXP

UGT2B15 protein results in increased metabolism of Emodin

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467

G

UDP glucuronosyltransferase family 2 member B7

decreases expression

ISO
EXP

Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

G

voltage-dependent anion channel 1

decreases expression

ISO

Emodin results in decreased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vascular endothelial growth factor A

decreases expression

ISO

Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vimentin

decreases expression
multiple interactions

EXP

Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

X-ray repair cross complementing 1

affects expression

EXP

Emodin affects the expression of XRCC1 protein

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613

G

zinc finger protein 37

increases expression

ISO

Emodin results in increased expression of ZFP37 mRNA

NCBI chr 5:80,600,463...80,656,064
Ensembl chr 5:80,600,463...80,654,404

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BAG cochaperone 3

increases expression

ISO

Lactulose results in increased expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

caspase 3

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of CASP3 protein modified form]; Lactulose inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]

PMID:30450033 PMID:35961375

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

epidermal growth factor receptor

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of EGFR mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

glutamic--pyruvic transaminase

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

heme oxygenase 1

increases expression

EXP

Lactulose results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

haptoglobin

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HP protein]

NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518

G

heat shock protein family B (small) member 8

increases expression

ISO

Lactulose results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

interleukin 1 beta

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL6 protein]

PMID:30450033 PMID:36414212

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

microtubule-associated protein 1 light chain 3 beta

increases expression

ISO

Lactulose results in increased expression of MAP1LC3B mRNA

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

EXP

Lactulose inhibits the reaction [Thioacetamide results in increased expression of MAP3K5 protein]

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen-activated protein kinase 8

multiple interactions

EXP

Lactulose inhibits the reaction [Thioacetamide results in increased expression of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

MYC associated zinc finger protein

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of MAZ mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of MAZ protein]

NCBI chr 1:191,060,271...191,065,722
Ensembl chr 1:191,060,280...191,065,339

G

microRNA 34c

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of MIR34C mRNA]

NCBI chr 8:60,306,091...60,306,167

G

MYD88, innate immune signal transduction adaptor

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NFE2 like bZIP transcription factor 2

multiple interactions

EXP

Lactulose promotes the reaction [Methamphetamine results in increased expression of NFE2L2 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

Lactulose inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

occludin

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of OCLN mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

poly (ADP-ribose) polymerase 1

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of PARP1 protein modified form]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

EXP

Lactulose inhibits the reaction [Thioacetamide results in decreased phosphorylation of PIK3R1 protein]

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sequestosome 1

multiple interactions
increases expression

EXP
ISO

Lactulose promotes the reaction [Methamphetamine results in increased expression of SQSTM1 mRNA]
Lactulose results in increased expression of SQSTM1 mRNA

PMID:30335591 PMID:30450033

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

transcription factor EB

affects localization
multiple interactions

ISO

Lactulose affects the localization of TFEB protein
Cyclosporine inhibits the reaction [Lactulose affects the localization of TFEB protein]

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

tight junction protein 1

multiple interactions

EXP

Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of TJP1 mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

toll-like receptor 4

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO
EXP

Lactulose inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Lactulose inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; Lactulose inhibits the reaction [Thioacetamide results in increased expression of TNF protein]

PMID:2311978 PMID:30450033 PMID:35961375

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor associated factor 6

multiple interactions

EXP

Lactulose inhibits the reaction [Methamphetamine results in increased expression of TRAF6 protein]

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

zinc finger with KRAB and SCAN domains 3

increases expression

ISO

Lactulose results in increased expression of ZKSCAN3 mRNA

NCBI chr17:47,912,816...47,928,553
Ensembl chr17:47,912,912...47,928,551

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20871
role	20829
application	20632
pharmaceutical	20427
drug	20427
laxative	284
D-glucitol +	41
aloin	0
aloin A +	0
aloin B +	0
carboxymethylcellulose	0
castor oil	1
emodin +	231
emodin(1-)	0
lactitol +	0
lactulose	28
magnesium citrate	0
magnesium sulfate heptahydrate	0
maltitol	0
pentaerythritol	0
potassium bitartrate	0
potassium sodium L-tartrate	0
sennoside	0
sennosides +	0
trimagnesium dicitrate	0

paths to the root