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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tris(picolinato)chromium
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Accession:CHEBI:50369 term browser browse the term
Definition:A chromium coordination entity that has formula C18H12CrN3O6.
Synonyms:exact_synonym: tris(pyridine-2-carboxylato-kappa(2)N,O)chromium;   tris(pyridine-2-carboxylato-kappa(2)N,O)chromium(III)
 related_synonym: 2-pyridinecarboxylic acid, chromium salt;   Chromax;   Cr(Pic)3;   CrPic;   Divista;   Formula=C18H12CrN3O6;   InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3;   InChIKey=CBDQOLKNTOMMTL-UHFFFAOYSA-K;   SMILES=O=C1O[Cr]23(OC(=O)C4=CC=CC=[N]24)(OC(=O)C2=CC=CC=[N]32)[N]2=CC=CC=C12;   chromium 2-pyridinecarboxylate;   chromium picolinate;   chromium tripicolinate;   chromium(III) picolinate;   chromium(III) trispicolinate;   picolinic acid chromium(III) salt;   picolinic acid, chromium salt;   pyridine-2-carboxylic acid chromium(III) salt;   tris(2-pyridinecarboxylato-N(1),O(2))chromium
 xref: AGR:IND605885006;   Beilstein:456376;   CAS:14639-25-9;   Chemspider:133913;   DrugBank:DB11255;   Gmelin:1305220;   Gmelin:392628
 xref_mesh: MESH:C079689
 xref: PMID:11849034;   PMID:15886052;   PMID:16216543;   PMID:16877033;   PMID:16887379;   PMID:17418471;   PMID:18408898;   PMID:23211098;   PMID:29380257;   PMID:29961187;   PMID:31778961;   PMID:31898080;   PMID:31994278;   PMID:32804855;   PMID:32961883;   PMID:33822801;   PMID:33997348;   PMID:34357081;   PMID:7838011;   Wikipedia:Chromium(III)_picolinate


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tris(picolinato)chromium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]; chromium tripicolinate affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; INS1 protein affects the reaction [chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] CTD PMID:9446840 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased expression of BAX protein] CTD PMID:19376147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO chromium tripicolinate results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased activity of CASP3 protein]		 CTD PMID:19376147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
chromium tripicolinate results in decreased activity of CAT protein		 CTD PMID:19693677 PMID:23122718 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of GSR protein] CTD PMID:23122718 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form CTD PMID:17684468 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP chromium tripicolinate affects the reaction [INS1 protein affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]]; chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; INS1 protein affects the reaction [chromium tripicolinate affects the reaction [[AVP protein results in increased uptake of Calcium] which results in increased secretion of Calcium]] CTD PMID:9446840 PMID:16424121 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP chromium tripicolinate promotes the reaction [INS1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:16424121 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions EXP chromium tripicolinate results in decreased expression of and results in decreased activity of PTPN1 protein CTD PMID:16424121 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        pharmacological role 19122
          anti-obesity agent 521
            tris(picolinato)chromium 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  metal atom 17873
                    transition element atom 17231
                      d-block element atom 17226
                        chromium group element atom 7965
                          chromium atom 6817
                            chromium molecular entity 6797
                              chromium coordination entity 5614
                                tris(picolinato)chromium 10
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