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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:6-methylprednisolone
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Accession:CHEBI:50366 term browser browse the term
Definition:A 3-oxo-Delta(1),Delta(4)-steroid that has formula C22H30O5.
Synonyms:related_synonym: (11beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione;   11beta,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
 xref: Beilstein:7113955
 chemrof_formula: C22H30O5
 chemrof_inchi: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12?,14-,15-,17-,19+,20-,21-,22-/m0/s1
 chemrof_inchikey: VHRSUDSXCMQTMA-UWKORSIYSA-N
 chemrof_smiles: [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CC(C)C2=CC(=O)C=C[C@@]21C
 cyclic_relationship: has_functional_parent CHEBI:8378


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6alpha-methylprednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases secretion
increases expression 		ISO ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]
Methylprednisolone results in increased expression of ABCB1 mRNA; Methylprednisolone results in increased expression of ABCB1 protein 		CTD PMID:16932953 PMID:22079615 PMID:22464980 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Methylprednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214 		JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Methylprednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions 		EXP Methylprednisolone results in decreased phosphorylation of AKT1 protein
naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein] 		CTD PMID:15187100 PMID:30878453 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases secretion 		EXP Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Methylprednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218 		JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Methylprednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Methylprednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980 		JBrowse link
G Ar androgen receptor multiple interactions ISO Methylprednisolone binds to and results in decreased activity of AR protein; Methylprednisolone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Methylprednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein] CTD PMID:17570061 PMID:26093215 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:17570061 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Methylprednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases secretion
multiple interactions
decreases expression 		EXP Methylprednisolone results in decreased secretion of BGLAP protein
[Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of BGLAP mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of BGLAP protein]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in increased expression of BGLAP mRNA]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in increased expression of BGLAP protein]
Methylprednisolone results in decreased expression of BGLAP mRNA; Methylprednisolone results in decreased expression of BGLAP protein 		CTD PMID:30291735 PMID:37659742 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Methylprednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967 		JBrowse link
G Capn2 calpain 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein] CTD PMID:17570061 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17570061 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity 		EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Methylprednisolone results in increased activity of CAT protein 		CTD PMID:1942778 PMID:30291735 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Methylprednisolone results in decreased expression of CCL20 mRNA; Methylprednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Methylprednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Methylprednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Methylprednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:172,910,681...172,922,062 		JBrowse link
G Clgn calmegin decreases expression ISO Methylprednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression 		EXP
ISO 		Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Methylprednisolone results in increased expression of COL1A1 mRNA 		CTD PMID:19192274 PMID:26093215 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] CTD PMID:1762292 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Methylprednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylprednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
increases activity 		ISO Methylprednisolone results in decreased expression of CYP3A4 mRNA
Methylprednisolone results in increased activity of CYP3A4 protein 		CTD PMID:15964336 PMID:16837568 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions 		EXP Methylprednisolone results in increased expression of DDIT4 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein] 		CTD PMID:21931329 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594 		JBrowse link
G Dmd dystrophin multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:51,070,273...53,437,835 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA] CTD PMID:7756592 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Methylprednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methylprednisolone binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G F8 coagulation factor VIII increases expression ISO Methylprednisolone results in increased expression of F8 protein CTD PMID:20405515 NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions 		EXP Methylprednisolone results in increased expression of FABP4 mRNA
bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in increased expression of FABP4 mRNA] 		CTD PMID:37659742 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fbln1 fibulin 1 increases expression ISO Methylprednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965 		JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions 		EXP Methylprednisolone results in increased expression of FBXO32 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FBXO32 protein] 		CTD PMID:21931329 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Fcer2 Fc epsilon receptor II multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein] CTD PMID:11997017 NCBI chr12:6,540,697...6,552,364
Ensembl chr12:6,540,703...6,549,374 		JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions 		EXP Methylprednisolone results in increased expression of FOXO1 protein
echinacoside inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]; Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein] 		CTD PMID:21931329 PMID:38336255 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Methylprednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Methylprednisolone results in decreased expression of GFAP protein CTD PMID:18509235 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gip gastric inhibitory polypeptide increases secretion EXP Methylprednisolone results in increased secretion of GIP protein CTD PMID:6753106 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216 		JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Methylprednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:31,689,485...31,836,199
Ensembl chr  X:31,690,359...31,733,272 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity 		EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Methylprednisolone results in increased activity of GPX1 protein 		CTD PMID:1942778 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsdme gasdermin E decreases expression ISO Methylprednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:80,588,614...80,641,525 		JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Methylprednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,854,612...88,897,043
Ensembl chr 4:88,854,640...88,896,993 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Methylprednisolone results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA] CTD PMID:26093215 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Methylprednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity 		ISO [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
Methylprednisolone results in decreased activity of HTR3A protein 		CTD PMID:15329590 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Methylprednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Methylprednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781 		JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Methylprednisolone results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750 		JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Methylprednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877 		JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Methylprednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Methylprednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Methylprednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521 		JBrowse link
G Il10 interleukin 10 increases expression ISO Methylprednisolone results in increased expression of IL10 protein CTD PMID:28557239 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA] CTD PMID:26093215 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Methylprednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Methylprednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression 		ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]
Methylprednisolone results in decreased expression of IL4 protein 		CTD PMID:7988651 PMID:11997017 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein] CTD PMID:11997017 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Methylprednisolone results in decreased expression of IL5 protein CTD PMID:7988651 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		EXP
ISO 		Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]
Methylprednisolone results in decreased expression of IL6 mRNA; Methylprednisolone results in decreased expression of IL6 protein 		CTD PMID:19192274 PMID:26093215 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO cobaltiprotoporphyrin inhibits the reaction [Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:15919478 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Methylprednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Methylprednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Methylprednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein] CTD PMID:11997017 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:1762292 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760 		JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:1762292 NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:118,056,935...118,069,090 		JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Methylprednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Methylprednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
decreases expression 		EXP cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein] CTD PMID:12904460 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Methylprednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882 		JBrowse link
G Mbp myelin basic protein decreases expression ISO Methylprednisolone results in decreased expression of MBP protein CTD PMID:18509235 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Methylprednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Methylprednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613 		JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression 		EXP
ISO 		Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]
Methylprednisolone results in decreased expression of MPO protein
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein] 		CTD PMID:26093215 PMID:28557239 PMID:30891624 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA] CTD PMID:26093215 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Methylprednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904 		JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Methylprednisolone results in decreased expression of COXFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:65,242,169...65,244,296
Ensembl chr 7:65,242,135...65,244,277 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA] CTD PMID:26093215 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA] CTD PMID:26093215 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nid2 nidogen 2 increases expression ISO Methylprednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,506,756...4,562,949 		JBrowse link
G Nmb neuromedin B decreases expression ISO Methylprednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22422321 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Methylprednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Methylprednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Methylprednisolone results in decreased expression of OAS3 mRNA CTD PMID:19192274 NCBI chr12:41,439,645...41,463,392
Ensembl chr12:41,439,643...41,464,420 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Methylprednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Methylprednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789 		JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:75,825,626...75,863,296
Ensembl chr11:75,825,585...75,878,165 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Methylprednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression 		EXP bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in increased expression of PPARG mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in increased expression of PPARG protein]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in decreased expression of PPARG mRNA]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in decreased expression of PPARG protein]
Methylprednisolone results in increased expression of PPARG mRNA; Methylprednisolone results in increased expression of PPARG protein 		CTD PMID:37659742 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Methylprednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:47,920,480...47,943,547
Ensembl chr13:47,922,590...47,932,324 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Methylprednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form] CTD PMID:26930420 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin increases activity
multiple interactions 		EXP Methylprednisolone results in increased activity of REN protein
Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein] 		CTD PMID:235222 PMID:6277579 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Methylprednisolone results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884 		JBrowse link
G Rig1 RNA sensor RIG-1 decreases expression ISO Methylprednisolone results in decreased expression of RIGI mRNA CTD PMID:19192274 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Methylprednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663 		JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Methylprednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:146,690,577...146,714,394 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Methylprednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
decreases expression 		EXP bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of RUNX2 mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of RUNX2 protein]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in increased expression of RUNX2 protein]
Methylprednisolone results in decreased expression of RUNX2 mRNA; Methylprednisolone results in decreased expression of RUNX2 protein 		CTD PMID:37659742 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Methylprednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:90,415,977...90,436,976 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Methylprednisolone results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Sms spermine synthase decreases expression ISO Methylprednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:41,331,693...41,387,713
Ensembl chr  X:41,331,799...41,387,712 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
decreases expression 		EXP
ISO 		[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein
Methylprednisolone results in increased activity of SOD2 protein
Methylprednisolone results in decreased expression of SOD2 mRNA 		CTD PMID:1942778 PMID:19192274 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Methylprednisolone results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Methylprednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein] CTD PMID:11997017 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Sts steroid sulfatase increases expression ISO Methylprednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:46,102,548...46,111,104 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] CTD PMID:26093215 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Methylprednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Methylprednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		EXP
ISO 		Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]
Methylprednisolone results in decreased expression of TNF protein
[Cyclophosphamide co-treated with Methylprednisolone] inhibits the reaction [Paraquat results in increased expression of TNF protein] 		CTD PMID:8384958 PMID:26093215 PMID:28557239 PMID:33737140 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Methylprednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:136,298,082...136,311,106 		JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions 		EXP Methylprednisolone results in increased expression of TRIM63 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of TRIM63 protein] 		CTD PMID:21931329 NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Methylprednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Vwf von Willebrand factor decreases expression
increases expression 		ISO Methylprednisolone results in decreased expression of VWF protein
Methylprednisolone results in increased expression of VWF protein 		CTD PMID:7491699 PMID:20405515 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      group 20774
        organic group 19348
          3-oxo-Delta(4)-steroid group 9086
            3-oxo-Delta(4) steroid 9083
              3-oxo-Delta(1),Delta(4)-steroid 5259
                6-methylprednisolone 132
                  6alpha-methylprednisolone 132
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbonyl compound 18827
                                    ketone 17484
                                      oxo steroid 9896
                                        3-oxo steroid 9875
                                          3-oxo-Delta(1) steroid 5259
                                            3-oxo-Delta(1),Delta(4)-steroid 5259
                                              6-methylprednisolone 132
                                                6alpha-methylprednisolone 132
paths to the root