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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:milbemycin
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Accession:CHEBI:50345 term browser browse the term
Synonyms:related_synonym: milbemycins
 xref_mesh: MESH:C027837
 xref: Wikipedia:Milbemycin


show annotations for term's descendants           Sort by:
milbemycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
decreases expression		 ISO moxidectin results in decreased activity of ABCB1A protein
moxidectin results in decreased expression of ABCB1 protein		 CTD PMID:17134887 PMID:21458446 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases export
multiple interactions		 ISO ABCG2 protein results in increased export of moxidectin
tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of moxidectin]		 CTD PMID:19428349 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ano1 anoctamin 1 decreases activity ISO moxidectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; moxidectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
Nemadectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO nemadectin results in decreased expression of ABCB1 mRNA; nemadectin results in decreased expression of ABCB1 protein CTD PMID:20487225 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
Selamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO selamectin results in decreased activity of ABCB1A protein
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to selamectin		 CTD PMID:17134887 PMID:19161460 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions ISO [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to selamectin CTD PMID:19161460 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Ano1 anoctamin 1 decreases activity ISO selamectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO selamectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO selamectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Mxd1 max dimerization protein 1 multiple interactions ISO selamectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; selamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; selamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions ISO selamectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          metabolite 19539
            prokaryotic metabolite 18588
              bacterial metabolite 18588
                milbemycin 10
                  (1R,4S,4'S,5'S,6R,6'S,8R,10E,13R,14E,16Z,20R,21R,24S)-4',21,24-trihydroxy-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2,18-dione 0
                  (1S,4R,4'S,5'S,6'S,7R,8R,9S,10E,12E,14R,16E,19R,21R)-4',8,9-trihydroxy-10-(hydroxymethyl)-7-methoxy-5',6,14,16-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-5,10,12,16-tetraene-21,2'-oxane]-3-one 0
                  (1S,5'R,6'R,10Z,12Z,14S,15S,16Z,19R,21S)-6'-[(2S)-butan-2-yl]-7,15-dihydroxy-5',6,10,14,16-pentamethylspiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-4(9),5,7,10,12,16-hexaene-21,2'-oxane]-3,4'-dione 0
                  27-formaldehyde-milbemycin beta14 0
                  4,25-diethyl-4,25-demethyl-milbemycin beta3 0
                  5-Oxoavermectin "2a" aglycone 0
                  5-Oxoavermectin "2b" aglycone 0
                  5-Oxoavermectin ''2a'' aglycone 0
                  6,8a-Seco-6,8a-deoxy-2,5-didehydroaverme 0
                  6,8a-Seco-6,8a-deoxy-5-oxoavermectin''2b''aglycone 0
                  6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone 0
                  Delta-2-Ivermectin B1a 0
                  Doramectin congener 1 0
                  Doramectin congener 3 0
                  Ivermectin B1 aglycone 0
                  Ivermectin monosaccharide 0
                  LL-F28249 beta 0
                  LL-F28249alpha 0
                  LL-F28249gamma 0
                  LSM-1593 0
                  LSM-1662 0
                  LSM-5397 0
                  Milbemycin A3 oxime 0
                  Milbemycin A4 oxime 0
                  Milbemycin J 0
                  Milbemycin K 0
                  Milbemycin alpha20 0
                  Milbemycin alpha21 0
                  Milbemycin alpha22 0
                  Milbemycin alpha23 0
                  Milbemycin alpha24 0
                  Milbemycin alpha25 0
                  Milbemycin alpha26 0
                  Milbemycin alpha27 0
                  Milbemycin alpha28 0
                  Milbemycin alpha29 0
                  Milbemycin alpha30 0
                  Milbemycin beta10 0
                  Milbemycin beta11 0
                  Milbemycin beta12 0
                  Milbemycin beta13 0
                  Milbemycin beta14 0
                  Milbemycin beta2 0
                  Milbemycin beta3 0
                  Milbemycin beta9 0
                  Milbemycin oxime 0
                  Moxidectin 0
                  Nemadectin 1
                  Pesticide4_Ivermectin_C48H74O14_22,23-dihydroavermectin B1 0
                  Selamectin 9
                  Tenvermectin C 0
                  Tenvermectin D 0
                  UK-78,624 0
                  UK-78614 0
                  UK-78618 0
                  UK-78621 0
                  UK-78629 0
                  UK-78630 0
                  UK-79465 0
                  VM 44857 0
                  VM 44864 0
                  VM 44865 0
                  VM 44866 0
                  VM-44857 0
                  VM-44864 0
                  VM-44865 0
                  VM-44866 0
                  VM44867 0
                  VM44868 0
                  VM47704 0
                  VM48130 0
                  VM48633 0
                  VM48640 0
                  VM48641 0
                  VM48642 0
                  VM54168 0
                  VM54339 0
                  [(3'R,4S,5'R,6S,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-3',21,24-trihydroxy-5',11,13,22-tetramethyl-12-(2-methylpropanoyloxy)-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-4'-yl] 2-methylpropanoate 0
                  [(4S,5'S,6R,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-12-yl] 2-methylpropanoate 0
                  epi-Ivermectin B1a 0
                  milbemycin A3 + 0
                  milbemycin A4 + 0
                  milbemycin D 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  ester 17461
                                    carboxylic ester 16750
                                      lactone 13298
                                        macrocyclic lactone 7583
                                          macrolide 7531
                                            avermectin analogue 10
                                              milbemycin 10
                                                (1R,4S,4'S,5'S,6R,6'S,8R,10E,13R,14E,16Z,20R,21R,24S)-4',21,24-trihydroxy-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2,18-dione 0
                                                (1S,4R,4'S,5'S,6'S,7R,8R,9S,10E,12E,14R,16E,19R,21R)-4',8,9-trihydroxy-10-(hydroxymethyl)-7-methoxy-5',6,14,16-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-5,10,12,16-tetraene-21,2'-oxane]-3-one 0
                                                (1S,5'R,6'R,10Z,12Z,14S,15S,16Z,19R,21S)-6'-[(2S)-butan-2-yl]-7,15-dihydroxy-5',6,10,14,16-pentamethylspiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-4(9),5,7,10,12,16-hexaene-21,2'-oxane]-3,4'-dione 0
                                                27-formaldehyde-milbemycin beta14 0
                                                4,25-diethyl-4,25-demethyl-milbemycin beta3 0
                                                5-Oxoavermectin "2a" aglycone 0
                                                5-Oxoavermectin "2b" aglycone 0
                                                5-Oxoavermectin ''2a'' aglycone 0
                                                6,8a-Seco-6,8a-deoxy-2,5-didehydroaverme 0
                                                6,8a-Seco-6,8a-deoxy-5-oxoavermectin''2b''aglycone 0
                                                6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone 0
                                                Delta-2-Ivermectin B1a 0
                                                Doramectin congener 1 0
                                                Doramectin congener 3 0
                                                Ivermectin B1 aglycone 0
                                                Ivermectin monosaccharide 0
                                                LL-F28249 beta 0
                                                LL-F28249alpha 0
                                                LL-F28249gamma 0
                                                LSM-1593 0
                                                LSM-1662 0
                                                LSM-5397 0
                                                Milbemycin A3 oxime 0
                                                Milbemycin A4 oxime 0
                                                Milbemycin J 0
                                                Milbemycin K 0
                                                Milbemycin alpha20 0
                                                Milbemycin alpha21 0
                                                Milbemycin alpha22 0
                                                Milbemycin alpha23 0
                                                Milbemycin alpha24 0
                                                Milbemycin alpha25 0
                                                Milbemycin alpha26 0
                                                Milbemycin alpha27 0
                                                Milbemycin alpha28 0
                                                Milbemycin alpha29 0
                                                Milbemycin alpha30 0
                                                Milbemycin beta10 0
                                                Milbemycin beta11 0
                                                Milbemycin beta12 0
                                                Milbemycin beta13 0
                                                Milbemycin beta14 0
                                                Milbemycin beta2 0
                                                Milbemycin beta3 0
                                                Milbemycin beta9 0
                                                Milbemycin oxime 0
                                                Moxidectin 0
                                                Nemadectin 1
                                                Pesticide4_Ivermectin_C48H74O14_22,23-dihydroavermectin B1 0
                                                Selamectin 9
                                                Tenvermectin C 0
                                                Tenvermectin D 0
                                                UK-78,624 0
                                                UK-78614 0
                                                UK-78618 0
                                                UK-78621 0
                                                UK-78629 0
                                                UK-78630 0
                                                UK-79465 0
                                                VM 44857 0
                                                VM 44864 0
                                                VM 44865 0
                                                VM 44866 0
                                                VM-44857 0
                                                VM-44864 0
                                                VM-44865 0
                                                VM-44866 0
                                                VM44867 0
                                                VM44868 0
                                                VM47704 0
                                                VM48130 0
                                                VM48633 0
                                                VM48640 0
                                                VM48641 0
                                                VM48642 0
                                                VM54168 0
                                                VM54339 0
                                                [(3'R,4S,5'R,6S,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-3',21,24-trihydroxy-5',11,13,22-tetramethyl-12-(2-methylpropanoyloxy)-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-4'-yl] 2-methylpropanoate 0
                                                [(4S,5'S,6R,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-12-yl] 2-methylpropanoate 0
                                                epi-Ivermectin B1a 0
                                                milbemycin A3 + 0
                                                milbemycin A4 + 0
                                                milbemycin D 0
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