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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1H-indol-3-ylmethyl group
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Accession:CHEBI:50337 term browser browse the term
Synonyms:exact_synonym: 1H-indol-3-ylmethyl
 related_synonym: Formula=C9H8N;   SMILES=N1C=C(C=2C=CC=CC12)C*;   tryptophan side-chain


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1-methyltryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein] CTD PMID:35687267 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CCND1 protein] CTD PMID:35687267 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of CYP1B1 protein] CTD PMID:35687267 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of E2F1 protein] CTD PMID:35687267 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Etv6 ETS variant transcription factor 6 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETV6 protein] CTD PMID:35687267 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 decreases activity ISO 1-methyltryptophan results in decreased activity of IDO2 protein CTD PMID:32289347 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MKI67 protein] CTD PMID:35687267 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of POU5F1 protein] CTD PMID:35687267 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Runx1 RUNX family transcription factor 1 multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of RUNX1 protein] CTD PMID:35687267 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO 1-methyltryptophan inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of TDO2 protein] CTD PMID:35687267 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein decreases expression ISO 5-Hydroxytryptophan results in decreased expression of AFP mRNA CTD PMID:32926198 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of GATA4 mRNA CTD PMID:32926198 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO 5-Hydroxytryptophan results in decreased expression of NANOG mRNA CTD PMID:32926198 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA CTD PMID:32926198 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 multiple interactions EXP ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
L-tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO Tryptophan results in increased expression of AHR mRNA CTD PMID:32781018 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases abundance		 ISO PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Tryptophan] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA]; [Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA
Tryptophan results in increased expression of CYP1A1 mRNA		 CTD PMID:32781018 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA]; [Tryptophan co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA
Tryptophan results in increased expression of CYP1B1 mRNA		 CTD PMID:32781018 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
increases abundance		 ISO Tryptophan results in increased expression of IDO1 protein
IDO1 gene mutant form results in increased abundance of Tryptophan		 CTD PMID:32781018 PMID:32871117 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]] CTD PMID:32781018 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression
multiple interactions		 ISO Tryptophan results in increased expression of IGFBP1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]		 CTD PMID:32781018 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO [amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan
[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan; PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of Tryptophan]		 CTD PMID:39172838 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Prl prolactin multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; IFNG protein promotes the reaction [Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; Tryptophan promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]
Tryptophan results in increased expression of PRL mRNA		 CTD PMID:32781018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Tryptophan results in increased expression of SLC7A5 mRNA CTD PMID:32781018 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases abundance ISO TDO2 gene mutant form results in increased abundance of Tryptophan CTD PMID:32871117 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
N-acetyl-L-tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP N-acetyltryptophan inhibits the reaction [Aluminum Chloride results in decreased activity of ACHE protein] CTD PMID:29185389 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP2 protein] CTD PMID:37702290 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP3 protein] CTD PMID:37702290 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of CASP9 protein] CTD PMID:37702290 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in decreased activity of CAT protein] CTD PMID:37702290 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO N-acetyltryptophan inhibits the reaction [Cobalt-60 results in increased activity of XDH protein] CTD PMID:37702290 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases expression EXP tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring RGD PMID:32604820 RGD:401793718 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring RGD PMID:32604820 RGD:401793718 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor decreases expression EXP tryptophan in pregnant dams decreases expression of mRNA in kidney of male offspring RGD PMID:32604820 RGD:401793718 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression EXP tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring RGD PMID:32604820 RGD:401793718 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 increases expression EXP tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring RGD PMID:32604820 RGD:401793718 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP tryptophan in pregnant dams increases expression of mRNA in kidney of male offspring RGD PMID:32604820 RGD:401793718 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
violacein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 increases activity ISO violacein results in increased activity of CASP2 protein CTD PMID:20416285 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity ISO violacein results in increased activity of CASP3 protein CTD PMID:20416285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO violacein results in increased activity of CASP9 protein CTD PMID:20416285 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      group 19818
        organic group 18984
          organic univalent group 18680
            organyl group 18680
              proteinogenic amino-acid side-chain group 12161
                1H-indol-3-ylmethyl group 38
                  tryptophan + 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  group 19818
                    organic group 18984
                      organic univalent group 18680
                        organyl group 18680
                          proteinogenic amino-acid side-chain group 12161
                            1H-indol-3-ylmethyl group 38
                              tryptophan + 38
paths to the root