CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: selanylmethyl group
Accession: CHEBI:50327
browse the term
Synonyms: exact_synonym: selanylmethyl
related_synonym: -CH2-SeH; Formula=CH3Se; HSe-CH2-; SMILES=[SeH]C*; selenocysteine side-chain
G
Alad
aminolevulinate dehydratase
decreases activity
EXP
Selenocysteine analog results in decreased activity of ALAD protein
CTD
PMID:14630126
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]
CTD
PMID:14572605
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
Selenocysteine results in increased expression of GSTA2 mRNA
CTD
PMID:12034368
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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Gsta3
glutathione S-transferase alpha 3
increases expression
EXP
Selenocysteine results in increased expression of GSTA3 mRNA
CTD
PMID:12034368
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
Selenocysteine results in increased expression of GSTA5 mRNA
CTD
PMID:12034368
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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Gstp1
glutathione S-transferase pi 1
increases expression
EXP
Selenocysteine results in increased expression of GSTP1 mRNA
CTD
PMID:12034368
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
CTD
PMID:14572605
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1
CTD
PMID:15897249
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc4
ATP binding cassette subfamily C member 4
multiple interactions decreases expression
EXP
Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA]
CTD
PMID:19025659
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA
CTD
PMID:25321483
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Ar
androgen receptor
decreases expression
ISO EXP
selenomethylselenocysteine results in decreased expression of AR protein selenomethylselenocysteine results in decreased expression of AR mRNA
CTD
PMID:16637076 PMID:19025659
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA
CTD
PMID:25321483
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Banp
Btg3 associated nuclear protein
increases expression
ISO
selenomethylselenocysteine results in increased expression of BANP mRNA
CTD
PMID:18514395
NCBI chr19:50,007,710...50,082,742
Ensembl chr19:50,007,881...50,082,738
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
selenomethylselenocysteine results in decreased expression of BCL2 mRNA selenomethylselenocysteine results in decreased expression of BCL2 protein [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
CTD
PMID:11396176 PMID:19360359
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA
CTD
PMID:25321483
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bcl2l11
Bcl2-like 11
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA
CTD
PMID:25321483
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bmal1
basic helix-loop-helix ARNT like 1
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of BMAL1 mRNA
CTD
PMID:19122877
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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Bmf
Bcl2 modifying factor
multiple interactions increases expression
ISO
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] selenomethylselenocysteine metabolite results in increased expression of BMF protein selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein
CTD
PMID:25321483
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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Casp3
caspase 3
increases activity increases expression multiple interactions
ISO
selenomethylselenocysteine results in increased activity of CASP3 protein selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]
CTD
PMID:15318939 PMID:25321483
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
increases expression multiple interactions
ISO
selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]
CTD
PMID:25321483
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp8
caspase 8
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form
CTD
PMID:25321483
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
multiple interactions increases expression
ISO
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]
CTD
PMID:25321483
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccna2
cyclin A2
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of CCNA2 protein
CTD
PMID:11396176
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnd1
cyclin D1
decreases expression multiple interactions
ISO EXP
selenomethylselenocysteine results in decreased expression of CCND1 protein selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein
CTD
PMID:11396176 PMID:18855134 PMID:19276161
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein
CTD
PMID:10656618
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein
CTD
PMID:25321483
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
EXP
selenomethylselenocysteine results in increased expression of CDKN1B protein
CTD
PMID:11396176 PMID:19276161
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Ces1d
carboxylesterase 1D
increases expression
ISO
selenomethylselenocysteine results in increased expression of CES1
CTD
PMID:15897249
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Chmp1a
charged multivesicular body protein 1A
increases expression
ISO
selenomethylselenocysteine results in increased expression of CHMP1A mRNA
CTD
PMID:18514395
NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein
CTD
PMID:18514395
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein
CTD
PMID:18514395
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Col4a5
collagen type IV alpha 5 chain
increases expression
ISO
selenomethylselenocysteine results in increased expression of COL4A5 mRNA
CTD
PMID:18514395
NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692
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Col6a1
collagen type VI alpha 1 chain
increases expression
ISO
selenomethylselenocysteine results in increased expression of COL6A1 mRNA
CTD
PMID:18514395
NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
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Col7a1
collagen type VII alpha 1 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL7A1 mRNA
CTD
PMID:18514395
NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252
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Cry2
cryptochrome circadian regulator 2
increases expression
EXP
selenomethylselenocysteine results in increased expression of CRY2 mRNA
CTD
PMID:19122877
NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5
CTD
PMID:15897249
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
selenomethylselenocysteine results in increased expression of DBP mRNA
CTD
PMID:19122877
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of DDIT3 mRNA
CTD
PMID:10656618
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dhcr24
24-dehydrocholesterol reductase
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of DHCR24 mRNA
CTD
PMID:19025659
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Drg1
developmentally regulated GTP binding protein 1
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1
CTD
PMID:15897249
NCBI chr14:78,103,876...78,119,976
Ensembl chr14:78,103,876...78,119,953
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Ep300
E1A binding protein p300
multiple interactions
ISO
selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Esr1
estrogen receptor 1
decreases expression multiple interactions
ISO
selenomethylselenocysteine results in decreased expression of ESR1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein
CTD
PMID:18855134
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Faslg
Fas ligand
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG
CTD
PMID:15897249
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
selenomethylselenocysteine results in increased expression of GADD45A mRNA
CTD
PMID:10656618
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gpx1
glutathione peroxidase 1
increases activity increases expression
ISO
selenomethylselenocysteine results in increased activity of GPX1 protein selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein
CTD
PMID:18514395 PMID:19033020
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gpx4
glutathione peroxidase 4
increases expression
ISO
selenomethylselenocysteine results in increased expression of GPX4 mRNA
CTD
PMID:18514395
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Grik1
glutamate ionotropic receptor kainate type subunit 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of GRIK1 mRNA
CTD
PMID:18514395
NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
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Grik3
glutamate ionotropic receptor kainate type subunit 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of GRIK3 mRNA
CTD
PMID:18514395
NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307
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Hdac8
histone deacetylase 8
multiple interactions
ISO
HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923
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Igf1r
insulin-like growth factor 1 receptor
increases expression
ISO
selenomethylselenocysteine results in increased expression of IGF1R mRNA
CTD
PMID:18514395
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation
EXP
selenomethylselenocysteine results in increased phosphorylation of JUN protein
CTD
PMID:19276161
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Klk1b3
kallikrein 1-related peptidase B3
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of KLK3 protein
CTD
PMID:16637076
NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
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Mki67
marker of proliferation Ki-67
multiple interactions decreases expression
ISO
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein selenomethylselenocysteine results in decreased expression of MKI67 protein
CTD
PMID:18855134
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Msrb1
methionine sulfoxide reductase B1
increases expression
ISO
selenomethylselenocysteine results in increased expression of MSRB1 mRNA
CTD
PMID:18514395
NCBI chr10:13,764,883...13,770,609
Ensembl chr10:13,764,883...13,770,609
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]
CTD
PMID:21213327
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:21213327
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of P4HA1 mRNA
CTD
PMID:18514395
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases expression
ISO
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]
CTD
PMID:25321483
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Per2
period circadian regulator 2
increases expression
EXP
selenomethylselenocysteine results in increased expression of PER2 mRNA
CTD
PMID:19122877
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Per3
period circadian regulator 3
increases expression
EXP
selenomethylselenocysteine results in increased expression of PER3 mRNA
CTD
PMID:19122877
NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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Pgr
progesterone receptor
decreases expression multiple interactions
ISO
selenomethylselenocysteine results in decreased expression of PGR protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein
CTD
PMID:18855134
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
selenomethylselenocysteine results in increased expression of PPP1R15A mRNA
CTD
PMID:10656618
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Prkce
protein kinase C, epsilon
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of PRKCE protein
CTD
PMID:10656618
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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Prkcz
protein kinase C, zeta
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of PRKCZ protein
CTD
PMID:10656618
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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Rab3b
RAB3B, member RAS oncogene family
increases expression
ISO
selenomethylselenocysteine results in increased expression of RAB3B mRNA
CTD
PMID:18514395
NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
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Rab4a
RAB4A, member RAS oncogene family
increases expression
ISO
selenomethylselenocysteine results in increased expression of RAB4A mRNA
CTD
PMID:18514395
NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD
PMID:21213327
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Scarb1
scavenger receptor class B, member 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of SCARB1 mRNA
CTD
PMID:18514395
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Selenof
selenoprotein F
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOF mRNA
CTD
PMID:18514395
NCBI chr 2:233,642,075...233,674,853
Ensembl chr 2:233,641,932...233,674,846
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Selenop
selenoprotein P
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOP mRNA
CTD
PMID:18514395
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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Selenow
selenoprotein W
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOW mRNA
CTD
PMID:18514395
NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724 Ensembl chr 1:76,598,779...76,604,724
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Slc3a1
solute carrier family 3 member 1
increases uptake
ISO
SLC3A1 protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
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Slc6a19
solute carrier family 6 member 19
increases uptake
ISO
SLC6A19 protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962
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Slc6a20a
solute carrier family 6 member 20a
increases uptake
ISO
SLC6A20B protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 8:123,282,325...123,322,609
Ensembl chr 8:123,281,472...123,322,573
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Snap23
synaptosome associated protein 23
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of SNAP23 mRNA
CTD
PMID:18514395
NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
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Sort1
sortilin 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of SORT1 mRNA
CTD
PMID:18514395
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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Sp3
Sp3 transcription factor
multiple interactions
ISO
selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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Spp1
secreted phosphoprotein 1
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of SPP1 protein
CTD
PMID:15318939
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Srd5a1
steroid 5 alpha-reductase 1
multiple interactions
EXP
[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein
CTD
PMID:19025659
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]
CTD
PMID:25321483
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stx3
syntaxin 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of STX3 mRNA
CTD
PMID:18514395
NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
CTD
PMID:19360359
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Trnau1ap
tRNA selenocysteine 1 associated protein 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA
CTD
PMID:18514395
NCBI chr 5:144,507,044...144,524,142
Ensembl chr 5:144,507,615...144,524,131
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Xpa
XPA, DNA damage recognition and repair factor
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein]
CTD
PMID:15265038
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
selenocystine results in increased expression of BAX protein
CTD
PMID:35863474
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
selenocystine results in decreased expression of BCL2 protein
CTD
PMID:35863474
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions decreases expression
ISO
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [selenocystine results in decreased expression of CASP3 protein]
CTD
PMID:35863474
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
decreases expression
ISO
selenocystine results in decreased expression of CASP8 protein
CTD
PMID:35863474
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
decreases expression
ISO
selenocystine results in decreased expression of CASP9 protein
CTD
PMID:35863474
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases expression
ISO
selenocystine results in decreased expression of CAT protein
CTD
PMID:35863474
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions increases expression
ISO
NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA]
CTD
PMID:22807314
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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H2ax
H2A.X variant histone
increases phosphorylation
ISO
selenocystine results in increased phosphorylation of H2AX protein
CTD
PMID:35863474
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK1 protein]
CTD
PMID:23838314
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK3 protein]
CTD
PMID:23838314
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions affects localization
ISO
NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA] selenocystine affects the localization of NFE2L2 protein
CTD
PMID:22807314
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases expression affects expression
ISO
NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA] selenocystine results in increased expression of NQO1 protein selenocystine affects the expression of NQO1 mRNA
CTD
PMID:22807314
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Slc3a1
solute carrier family 3 member 1
increases uptake
ISO
SLC3A1 protein results in increased uptake of selenocystine
CTD
PMID:18845132
NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
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Sod1
superoxide dismutase 1
decreases expression
ISO
selenocystine results in decreased expression of SOD1 protein
CTD
PMID:35863474
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
decreases expression
ISO
selenocystine results in decreased expression of SOD2 protein
CTD
PMID:35863474
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Txnrd1
thioredoxin reductase 1
decreases response to substance increases expression multiple interactions
ISO
TXNRD1 protein results in decreased susceptibility to selenocystine selenocystine results in increased expression of TXNRD1 mRNA; selenocystine results in increased expression of TXNRD1 protein NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
CTD
PMID:20920480 PMID:22807314
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Xpa
XPA, DNA damage recognition and repair factor
multiple interactions decreases activity
ISO
selenocystine inhibits the reaction [Zinc binds to XPA protein] selenocystine results in decreased activity of XPA protein
CTD
PMID:15265038
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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