Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 5.99.1.2 (DNA topoisomerase) inhibitor
go back to main search page
Accession:CHEBI:50276 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Synonyms:related_synonym: DNA topoisomerase inhibitor;   DNA topoisomerase inhibitors;   EC 5.99.1.2 (DNA topoisomerase) inhibitors;   EC 5.99.1.2 (topoisomerase I) inhibitor;   EC 5.99.1.2 inhibitor;   EC 5.99.1.2 inhibitors;   topoisomerase I (EC 5.99.1.2) inhibitors;   topoisomerase I inhibitor;   topoisomerase I inhibitors;   type I DNA topoisomerase inhibitor;   type I DNA topoisomerase inhibitors

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 0
    role 0
      biological role 0
        biochemical role 0
          enzyme inhibitor 0
            EC 5.* (isomerase) inhibitor 0
              EC 5.99.* (other isomerases) inhibitor 0
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 0
                  topoisomerase inhibitor 0
                    EC 5.99.1.2 (DNA topoisomerase) inhibitor 0
                      (R)-homocamptothecin + 0
                      (S)-scoulerine + 0
                      SN-38 + 0
                      amarogentin 0
                      camptothecin 0
                      diflomotecan 0
                      dihydrobetulinic acid 0
                      disulfiram 0
                      ellagic acid + 0
                      feruloylagmatine + 0
                      irinotecan 0
                      irinotecan hydrochloride (anhydrous) + 0
                      irinotecan hydrochloride hydrate 0
                      kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      lucanthone + 0
                      manoalide 0
                      methyl brevifolincarboxylate 0
                      morin 0
                      rubitecan 0
                      saintopin 0
                      topopyrone A 0
                      topopyrone B 0
                      topopyrone C 0
                      topopyrone D 0
                      topotecan + 0
                      topotecan hydrochloride 0
paths to the root