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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 5.99.1.2 (DNA topoisomerase) inhibitor
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Accession:CHEBI:50276 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Synonyms:related_synonym: DNA topoisomerase inhibitor;   DNA topoisomerase inhibitors;   EC 5.99.1.2 (DNA topoisomerase) inhibitors;   EC 5.99.1.2 (topoisomerase I) inhibitor;   EC 5.99.1.2 inhibitor;   EC 5.99.1.2 inhibitors;   topoisomerase I (EC 5.99.1.2) inhibitors;   topoisomerase I inhibitor;   topoisomerase I inhibitors;   type I DNA topoisomerase inhibitor;   type I DNA topoisomerase inhibitors


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disulfiram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]; Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein] CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Disulfiram inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:10975995 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
morin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNLIP pancreatic lipase decreases activity EXP morin results in decreased activity of PNLIP protein CTD PMID:30032067 NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,772,911...126,790,001 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 5152
    role 5119
      biological role 5119
        biochemical role 5043
          enzyme inhibitor 520
            EC 5.* (isomerase) inhibitor 15
              EC 5.99.* (other isomerases) inhibitor 11
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 11
                  topoisomerase inhibitor 11
                    EC 5.99.1.2 (DNA topoisomerase) inhibitor 3
                      (R)-homocamptothecin + 0
                      (S)-scoulerine + 0
                      SN-38 + 0
                      amarogentin 0
                      camptothecin 0
                      diflomotecan 0
                      dihydrobetulinic acid 0
                      disulfiram 2
                      ellagic acid + 0
                      feruloylagmatine + 0
                      irinotecan 0
                      irinotecan hydrochloride (anhydrous) + 0
                      irinotecan hydrochloride hydrate 0
                      kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      lucanthone + 0
                      manoalide 0
                      methyl brevifolincarboxylate 0
                      morin 1
                      rubitecan 0
                      saintopin 0
                      topopyrone A 0
                      topopyrone B 0
                      topopyrone C 0
                      topopyrone D 0
                      topotecan + 0
                      topotecan hydrochloride 0
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