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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 5.99.1.2 (DNA topoisomerase) inhibitor
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Accession:CHEBI:50276 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Synonyms:related_synonym: DNA topoisomerase inhibitor;   DNA topoisomerase inhibitors;   EC 5.99.1.2 (DNA topoisomerase) inhibitors;   EC 5.99.1.2 (topoisomerase I) inhibitor;   EC 5.99.1.2 inhibitor;   EC 5.99.1.2 inhibitors;   topoisomerase I (EC 5.99.1.2) inhibitors;   topoisomerase I inhibitor;   topoisomerase I inhibitors;   type I DNA topoisomerase inhibitor;   type I DNA topoisomerase inhibitors


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      CHEBI ontology 22289
        role 22274
          biological role 22273
            biochemical role 21485
              enzyme inhibitor 19917
                EC 5.* (isomerase) inhibitor 8283
                  EC 5.99.* (other isomerases) inhibitor 7797
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 7797
                      topoisomerase inhibitor 7797
                        EC 5.99.1.2 (DNA topoisomerase) inhibitor 4039
                          (R)-homocamptothecin + 0
                          (S)-scoulerine + 0
                          SN-38 + 726
                          amarogentin 3
                          camptothecin 562
                          diflomotecan 0
                          dihydrobetulinic acid 0
                          disulfiram 622
                          ellagic acid + 170
                          feruloylagmatine + 0
                          irinotecan 726
                          irinotecan hydrochloride (anhydrous) + 0
                          irinotecan hydrochloride hydrate 0
                          kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          lucanthone + 199
                          manoalide 3
                          methyl brevifolincarboxylate 0
                          morin 111
                          rubitecan 17
                          saintopin 0
                          topopyrone A 0
                          topopyrone B 0
                          topopyrone C 0
                          topopyrone D 0
                          topotecan + 2674
                          topotecan hydrochloride 0
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