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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 5.99.1.2 (DNA topoisomerase) inhibitor
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Accession:CHEBI:50276 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Synonyms:related_synonym: DNA topoisomerase inhibitor;   DNA topoisomerase inhibitors;   EC 5.99.1.2 (DNA topoisomerase) inhibitors;   EC 5.99.1.2 (topoisomerase I) inhibitor;   EC 5.99.1.2 inhibitor;   EC 5.99.1.2 inhibitors;   topoisomerase I (EC 5.99.1.2) inhibitors;   topoisomerase I inhibitor;   topoisomerase I inhibitors;   type I DNA topoisomerase inhibitor;   type I DNA topoisomerase inhibitors


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  CHEBI ontology 0
    role 0
      biological role 0
        biochemical role 0
          enzyme inhibitor 0
            EC 5.* (isomerase) inhibitor 0
              EC 5.99.* (other isomerases) inhibitor 0
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 0
                  topoisomerase inhibitor 0
                    EC 5.99.1.2 (DNA topoisomerase) inhibitor 0
                      (R)-homocamptothecin + 0
                      (S)-scoulerine + 0
                      SN-38 + 0
                      amarogentin 0
                      camptothecin 0
                      diflomotecan 0
                      dihydrobetulinic acid 0
                      disulfiram 0
                      ellagic acid + 0
                      feruloylagmatine + 0
                      irinotecan 0
                      irinotecan hydrochloride (anhydrous) + 0
                      irinotecan hydrochloride hydrate 0
                      kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      lucanthone + 0
                      manoalide 0
                      methyl brevifolincarboxylate 0
                      morin 0
                      rubitecan 0
                      saintopin 0
                      topopyrone A 0
                      topopyrone B 0
                      topopyrone C 0
                      topopyrone D 0
                      topotecan + 0
                      topotecan hydrochloride 0
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