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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 5.99.1.2 (DNA topoisomerase) inhibitor
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Accession:CHEBI:50276 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Synonyms:related_synonym: DNA topoisomerase inhibitor;   DNA topoisomerase inhibitors;   EC 5.99.1.2 (DNA topoisomerase) inhibitors;   EC 5.99.1.2 (topoisomerase I) inhibitor;   EC 5.99.1.2 inhibitor;   EC 5.99.1.2 inhibitors;   topoisomerase I (EC 5.99.1.2) inhibitors;   topoisomerase I inhibitor;   topoisomerase I inhibitors;   type I DNA topoisomerase inhibitor;   type I DNA topoisomerase inhibitors


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      CHEBI ontology 19880
        role 19850
          biological role 19848
            biochemical role 19556
              enzyme inhibitor 18751
                EC 5.* (isomerase) inhibitor 7968
                  EC 5.99.* (other isomerases) inhibitor 7520
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 7520
                      topoisomerase inhibitor 7520
                        EC 5.99.1.2 (DNA topoisomerase) inhibitor 4043
                          (R)-homocamptothecin + 0
                          (S)-scoulerine + 0
                          SN-38 + 720
                          amarogentin 3
                          camptothecin 560
                          diflomotecan 0
                          dihydrobetulinic acid 0
                          disulfiram 619
                          ellagic acid + 170
                          feruloylagmatine + 0
                          irinotecan 720
                          irinotecan hydrochloride (anhydrous) + 0
                          irinotecan hydrochloride hydrate 0
                          kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          lucanthone + 189
                          manoalide 3
                          methyl brevifolincarboxylate 0
                          morin 111
                          rubitecan 17
                          saintopin 0
                          topopyrone A 0
                          topopyrone B 0
                          topopyrone C 0
                          topopyrone D 0
                          topotecan + 2698
                          topotecan hydrochloride 0
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