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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxydicarboxylic acid
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Accession:CHEBI:50263 term browser browse the term
Definition:Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Synonyms:related_synonym: 2-hydroxydicarboxylic acids;   Formula=C3H4O5(CH2)n
 alt_id: CHEBI:1154;   CHEBI:19636
 xref: KEGG:C03668
 cyclic_relationship: is_conjugate_acid_of CHEBI:167114


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2-hydroxyglutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH2 protein CTD PMID:28269980 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914 		JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH3 protein CTD PMID:28269980 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000 		JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase increases metabolic processing ISO D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate CTD PMID:15609246 NCBI chr 9:94,350,555...94,368,384
Ensembl chr 9:94,350,576...94,368,382 		JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [epigallocatechin gallate results in decreased expression of GLUD1 protein] which results in decreased abundance of alpha-hydroxyglutarate CTD PMID:31857147 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 affects abundance ISO IDH1 gene mutant form affects the abundance of alpha-hydroxyglutarate CTD PMID:22057236 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase increases abundance ISO L2HGDH gene mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:25800467 NCBI chr 6:88,164,429...88,205,585
Ensembl chr 6:88,164,440...88,205,578 		JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle affects expression ISO diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523 		JBrowse link
G Actn3 actinin alpha 3 affects expression ISO diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Adcy1 adenylate cyclase 1 affects expression ISO diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide affects expression ISO diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Agt angiotensinogen affects expression ISO diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO diethyl malate results in increased expression of ANGPTL4 mRNA CTD PMID:38498338 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression ISO diethyl malate results in increased expression of ASF1B mRNA CTD PMID:38498338 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 increases expression ISO diethyl malate results in increased expression of ATP6V1B2 mRNA CTD PMID:38498338 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO diethyl malate results in increased expression of BAG3 mRNA CTD PMID:38498338 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor increases expression ISO diethyl malate results in increased expression of BCAS2 mRNA CTD PMID:38498338 NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO diethyl malate results in increased expression of BCL2L11 mRNA CTD PMID:38498338 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Brd2 bromodomain containing 2 increases expression ISO diethyl malate results in increased expression of BRD2 mRNA CTD PMID:38498338 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G C3 complement C3 affects expression ISO diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 affects expression ISO diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 affects expression ISO diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 increases expression ISO diethyl malate results in increased expression of CASP3 mRNA CTD PMID:38498338 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cbr2 carbonyl reductase 2 affects expression ISO diethyl malate affects the expression of CBR2 mRNA CTD PMID:24814887 NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 affects expression
increases expression		 ISO diethyl malate affects the expression of CCL20 mRNA
diethyl malate results in increased expression of CCL20 mRNA		 CTD PMID:24814887 PMID:38498338 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression ISO diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 affects expression ISO diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO diethyl malate results in increased expression of CTGF mRNA CTD PMID:38498338 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO diethyl malate results in increased expression of CCNE2 mRNA CTD PMID:38498338 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO diethyl malate results in increased expression of CDK5R1 mRNA CTD PMID:38498338 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO diethyl malate results in increased expression of CHAC1 mRNA CTD PMID:38498338 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c increases expression ISO diethyl malate results in increased expression of CIDEC mRNA CTD PMID:38498338 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO diethyl malate results in increased expression of CKS2 mRNA CTD PMID:38498338 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO diethyl malate results in increased expression of CLK1 mRNA CTD PMID:38498338 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853 		JBrowse link
G Col2a1 collagen type II alpha 1 chain affects expression ISO diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression ISO diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Comp cartilage oligomeric matrix protein affects expression ISO diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845 		JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO diethyl malate results in increased expression of CSRNP1 mRNA CTD PMID:38498338 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions		 ISO diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]		 CTD PMID:24814887 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO diethyl malate results in increased expression of CYP4F3 mRNA CTD PMID:38498338 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression ISO diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO diethyl malate results in increased expression of DDIT3 mRNA CTD PMID:38498338 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects expression ISO diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dhx58 DEXH-box helicase 58 affects expression ISO diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO diethyl malate results in increased expression of DNAJB4 mRNA CTD PMID:38498338 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Edar ectodysplasin-A receptor affects expression ISO diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494 		JBrowse link
G Ednra endothelin receptor type A affects expression ISO diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Emg1 EMG1 N1-specific pseudouridine methyltransferase increases expression ISO diethyl malate results in increased expression of EMG1 mRNA CTD PMID:38498338 NCBI chr 4:157,509,258...157,517,540
Ensembl chr 4:157,509,277...157,517,540 		JBrowse link
G Eno2 enolase 2 increases expression ISO diethyl malate results in increased expression of ENO2 mRNA CTD PMID:38498338 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Epas1 endothelial PAS domain protein 1 affects expression ISO diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Epha7 Eph receptor A7 affects expression ISO diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Ephb2 Eph receptor B2 affects expression ISO diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Fam83d family with sequence similarity 83, member D increases expression ISO diethyl malate results in increased expression of FAM83D mRNA CTD PMID:38498338 NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects expression ISO diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects expression ISO diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO diethyl malate results in increased expression of FOSL1 mRNA CTD PMID:38498338 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fst follistatin affects expression ISO diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Fzd2 frizzled class receptor 2 affects expression ISO diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO diethyl malate results in increased expression of G6PD mRNA CTD PMID:38498338 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression ISO diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO diethyl malate results in increased expression of GCNT3 mRNA CTD PMID:38498338 NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562 		JBrowse link
G Ggt6 gamma-glutamyl transferase 6 affects expression ISO diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260 		JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gnao1 G protein subunit alpha o1 affects expression ISO diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gng7 G protein subunit gamma 7 affects expression ISO diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240 		JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 increases expression ISO diethyl malate results in increased expression of GNPDA1 mRNA CTD PMID:38498338 NCBI chr18:30,165,435...30,177,462
Ensembl chr18:30,165,427...30,177,486 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO diethyl malate results in increased expression of GPAT3 mRNA CTD PMID:38498338 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gsr glutathione-disulfide reductase affects expression ISO diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 affects expression ISO diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects expression ISO diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G H2ac4 H2A clustered histone 4 increases expression ISO diethyl malate results in increased expression of HIST1H2AC mRNA CTD PMID:38498338 NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression ISO diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hgf hepatocyte growth factor affects expression ISO diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D increases expression ISO diethyl malate results in increased expression of HIST1H2BD mRNA CTD PMID:38498338 NCBI chr17:42,792,887...42,793,268 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO diethyl malate results in increased expression of HMGCS2 mRNA CTD PMID:38498338 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression ISO diethyl malate results in increased expression of HMMR mRNA CTD PMID:38498338 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO diethyl malate results in increased expression of HMOX1 mRNA CTD PMID:38498338 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO diethyl malate results in increased expression of HSP90AA1 mRNA CTD PMID:38498338 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO diethyl malate results in increased expression of HSPA1A mRNA CTD PMID:38498338 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO diethyl malate results in increased expression of HSPA1B mRNA CTD PMID:38498338 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO diethyl malate results in increased expression of HSPA2 mRNA CTD PMID:38498338 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO diethyl malate results in increased expression of HSPA8 mRNA CTD PMID:38498338 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO diethyl malate results in increased expression of IFRD1 mRNA CTD PMID:38498338 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO diethyl malate results in increased expression of IGFBP3 mRNA CTD PMID:38498338 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Il15 interleukin 15 affects expression ISO diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il18 interleukin 18 affects expression ISO diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 affects expression ISO diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176 		JBrowse link
G Irf7 interferon regulatory factor 7 affects expression ISO diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression ISO diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Itga11 integrin subunit alpha 11 affects expression ISO diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407 		JBrowse link
G Itga3 integrin subunit alpha 3 affects expression ISO diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase increases expression ISO diethyl malate results in increased expression of JMJD6 mRNA CTD PMID:38498338 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182 		JBrowse link
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 affects expression ISO diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278 		JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478 		JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO diethyl malate results in increased expression of MAFF mRNA CTD PMID:38498338 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO diethyl malate results in increased expression of MAFG mRNA CTD PMID:38498338 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO diethyl malate results in increased expression of MAP1LC3B mRNA CTD PMID:38498338 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions		 ISO diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]		 CTD PMID:24814887 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation
multiple interactions		 ISO diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]		 CTD PMID:24814887 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO diethyl malate results in increased expression of MMP1 mRNA CTD PMID:38498338 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO diethyl malate results in increased expression of MMP3 mRNA CTD PMID:38498338 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Myl4 myosin, light chain 4 increases expression ISO diethyl malate results in increased expression of MYL4 mRNA CTD PMID:38498338 NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363 		JBrowse link
G Myl9 myosin light chain 9 affects expression ISO diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO diethyl malate results in increased expression of NDRG1 mRNA CTD PMID:38498338 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Odc1 ornithine decarboxylase 1 affects expression ISO diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO diethyl malate results in increased expression of OSGIN1 mRNA CTD PMID:38498338 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516 		JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression
multiple interactions		 ISO diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]		 CTD PMID:24814887 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfd platelet derived growth factor D affects expression ISO diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pf4 platelet factor 4 affects expression ISO diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 increases expression ISO diethyl malate results in increased expression of PFKFB4 mRNA CTD PMID:38498338 NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 affects expression ISO diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608 		JBrowse link
G Plin2 perilipin 2 increases expression ISO diethyl malate results in increased expression of PLIN2 mRNA CTD PMID:38498338 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Plxnc1 plexin C1 affects expression ISO diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO diethyl malate results in increased expression of PPP1R15A mRNA CTD PMID:38498338 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 affects expression ISO diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ptgis prostaglandin I2 synthase affects expression ISO diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ramp2 receptor activity modifying protein 2 affects expression ISO diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 affects expression ISO diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894 		JBrowse link
G Rig1 RNA sensor RIG-1 affects expression ISO diethyl malate affects the expression of RIGI mRNA CTD PMID:24814887 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO diethyl malate affects the expression of H2-DMB1 mRNA CTD PMID:24814887 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 affects expression ISO diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592 		JBrowse link
G Sema3b semaphorin 3B affects expression ISO diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919 		JBrowse link
G Sema4g semaphorin 4G affects expression ISO diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341 		JBrowse link
G Sema5a semaphorin 5A affects expression ISO diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084 		JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO diethyl malate results in increased expression of SERTAD1 mRNA CTD PMID:38498338 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO diethyl malate results in increased expression of SLC7A11 mRNA CTD PMID:38498338 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO diethyl malate results in increased expression of SRXN1 mRNA CTD PMID:38498338 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 increases expression ISO diethyl malate results in increased expression of TACC3 mRNA CTD PMID:38498338 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219 		JBrowse link
G Tes testin LIM domain protein increases expression ISO diethyl malate results in increased expression of TES mRNA CTD PMID:38498338 NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression
multiple interactions		 ISO diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]		 CTD PMID:24814887 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs2 thrombospondin 2 affects expression ISO diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Tnc tenascin C affects expression ISO diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B affects expression ISO diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type affects expression ISO diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO diethyl malate results in increased expression of TRIB3 mRNA CTD PMID:38498338 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Tslp thymic stromal lymphopoietin affects expression ISO diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO diethyl malate results in increased expression of VEGFA mRNA CTD PMID:38498338 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zbtb21 zinc finger and BTB domain containing 21 increases expression ISO diethyl malate results in increased expression of ZBTB21 mRNA CTD PMID:38498338 NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996 		JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO diethyl malate results in increased expression of ZNF274 mRNA CTD PMID:38498338 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086 		JBrowse link
G Zfp367 zinc finger protein 367 increases expression ISO diethyl malate results in increased expression of ZNF367 mRNA CTD PMID:38498338 NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287 		JBrowse link
malic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein decreases abundance
multiple interactions		 ISO APP protein mutant form results in decreased abundance of malic acid
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid; IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid]; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid]
PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of malic acid]		 CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein] CTD PMID:24732427 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
decreases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid] CTD PMID:39172838 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Mapt microtubule-associated protein tau decreases abundance
multiple interactions		 ISO MAPT protein mutant form results in decreased abundance of malic acid
PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of malic acid]		 CTD PMID:39172838 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO malic acid deficiency results in increased expression of MDH1 mRNA CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid CTD PMID:28223344 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO malic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid; IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid]; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of malic acid] CTD PMID:39172838 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      group 19849
        inorganic group 19428
          oxo group 18929
            organic oxo compound 18929
              carbonyl compound 18929
                dicarboxylic acids and O-substituted derivatives 11138
                  dicarboxylic acid 11132
                    2-hydroxydicarboxylic acid 163
                      (2E,4Z)-2-hydroxymuconic acid 0
                      (2Z,4E)-2-hydroxymuconic acid 0
                      (R)-2-ethylmalic acid 0
                      (R)-3,3-dimethylmalic acid 0
                      2,3-dimethylmalic acid + 0
                      2-(omega-methylthio)alkylmalic acid + 0
                      2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
                      2-hydroxyadipic acid + 0
                      2-hydroxyglutaric acid + 7
                      2-hydroxyoctanedioic acid 0
                      2-phosphinomethylmalic acid 0
                      3-(omega-methylthio)alkylmalic acid + 0
                      3-ethylmalic acid 0
                      3-isopropylmalic acid + 0
                      5-dehydro-4-deoxy-D-glucaric acid 0
                      citramalic acid + 0
                      dihydroxyfumaric acid 0
                      hydroxymalonic acid 0
                      malic acid + 157
                      phosphinomethylisomalic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbonyl compound 18929
                                    dicarboxylic acids and O-substituted derivatives 11138
                                      dicarboxylic acid 11132
                                        2-hydroxydicarboxylic acid 163
                                          (2E,4Z)-2-hydroxymuconic acid 0
                                          (2Z,4E)-2-hydroxymuconic acid 0
                                          (R)-2-ethylmalic acid 0
                                          (R)-3,3-dimethylmalic acid 0
                                          2,3-dimethylmalic acid + 0
                                          2-(omega-methylthio)alkylmalic acid + 0
                                          2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
                                          2-hydroxyadipic acid + 0
                                          2-hydroxyglutaric acid + 7
                                          2-hydroxyoctanedioic acid 0
                                          2-phosphinomethylmalic acid 0
                                          3-(omega-methylthio)alkylmalic acid + 0
                                          3-ethylmalic acid 0
                                          3-isopropylmalic acid + 0
                                          5-dehydro-4-deoxy-D-glucaric acid 0
                                          citramalic acid + 0
                                          dihydroxyfumaric acid 0
                                          hydroxymalonic acid 0
                                          malic acid + 157
                                          phosphinomethylisomalic acid 0
paths to the root