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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(+)-dexrazoxane
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Accession:CHEBI:50223 term browser browse the term
Definition:A razoxane that has formula C11H16N4O4.
Synonyms:exact_synonym: 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione
 related_synonym: (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione;   (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane;   Dextrorazoxane;   Formula=C11H16N4O4;   InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1;   InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N;   SMILES=C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1;   dexrazoxano;   dexrazoxanum
 xref: Beilstein:6658412;   Beilstein:8441732;   CAS:24584-09-6;   DrugBank:DB00380;   Drug_Central:839;   KEGG:D03730;   LINCS:LSM-5248
 xref_mesh: MESH:D064730
 xref: Wikipedia:Dexrazoxane


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(+)-dexrazoxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACAA2 mRNA CTD PMID:26873546 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ACAD9 mRNA CTD PMID:26873546 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACADM mRNA CTD PMID:26873546 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain decreases expression ISO Dexrazoxane results in decreased expression of ACADSB mRNA CTD PMID:26873546 NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 affects expression ISO Dexrazoxane affects the expression of ACOT2 mRNA CTD PMID:26873546 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ACOT9 mRNA CTD PMID:26873546 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559 		JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO Dexrazoxane results in decreased expression of ACOX1 mRNA CTD PMID:26873546 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Dexrazoxane results in decreased expression of ACSL1 mRNA CTD PMID:26873546 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Dexrazoxane inhibits the reaction [Cyclophosphamide results in increased expression of ACSL4 protein] CTD PMID:37690746 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 decreases expression
multiple interactions		 ISO Dexrazoxane results in decreased expression of ACSS1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACSS1 mRNA		 CTD PMID:26873546 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
G Ak4 adenylate kinase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of AK4 mRNA CTD PMID:26873546 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA CTD PMID:26873546 NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH6A1 mRNA CTD PMID:26873546 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Anxa10 annexin A10 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ANXA10 mRNA CTD PMID:26873546 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648 		JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ASS1 mRNA CTD PMID:26873546 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of ATP5F1A mRNA CTD PMID:26873546 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Dexrazoxane results in decreased expression of ATP5F1B mRNA CTD PMID:26873546 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases expression ISO Dexrazoxane results in increased expression of ATP5F1E mRNA CTD PMID:26873546 NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450 		JBrowse link
G Atp5mf ATP synthase membrane subunit f increases expression ISO Dexrazoxane results in increased expression of ATP5MF mRNA CTD PMID:26873546 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d increases expression ISO Dexrazoxane results in increased expression of ATP5PD mRNA CTD PMID:26873546 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ATP5PF mRNA CTD PMID:26873546 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP increases expression ISO Dexrazoxane results in increased expression of ATP5PO mRNA CTD PMID:26873546 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592 		JBrowse link
G Atrx ATRX, chromatin remodeler multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of ATRX protein; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of ATRX mRNA] CTD PMID:28973540 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAK1 mRNA CTD PMID:26873546 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAX mRNA; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX protein] CTD PMID:26873546 PMID:28973540 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Dexrazoxane results in increased expression of BCL2L1 mRNA CTD PMID:26873546 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 decreases expression ISO Dexrazoxane results in decreased expression of BCL2L10 mRNA CTD PMID:26873546 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BCL3 mRNA CTD PMID:26873546 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BDH1 mRNA CTD PMID:26873546 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BID mRNA CTD PMID:26873546 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Dexrazoxane results in increased expression of BNIP3 mRNA CTD PMID:26873546 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Dexrazoxane results in increased expression of BNIP3L mRNA CTD PMID:26873546 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BOK mRNA CTD PMID:26873546 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Bphl biphenyl hydrolase like multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BPHL mRNA CTD PMID:26873546 NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288 		JBrowse link
G Casp1 caspase 1 multiple interactions
decreases expression		 ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP1 mRNA
Dexrazoxane results in decreased expression of CASP1 mRNA		 CTD PMID:26873546 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP12 mRNA CTD PMID:26873546 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp14 caspase 14 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP14 mRNA CTD PMID:26873546 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405 		JBrowse link
G Casp2 caspase 2 increases expression ISO Dexrazoxane results in increased expression of CASP2 mRNA CTD PMID:26873546 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP4 mRNA CTD PMID:26873546 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp8 caspase 8 increases expression ISO Dexrazoxane results in increased expression of CASP8 mRNA CTD PMID:26873546 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Dexrazoxane results in decreased expression of CASP9 mRNA CTD PMID:26873546 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccdc80 coiled-coil domain containing 80 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of CCDC80 protein CTD PMID:30517846 NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO
EXP		 Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA]
Dexrazoxane inhibits the reaction [Daunorubicin results in increased expression of CDKN1A mRNA]		 CTD PMID:28973540 PMID:38290791 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chst15 carbohydrate sulfotransferase 15 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of CHST15 protein CTD PMID:30517846 NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO Dexrazoxane inhibits the reaction [carfilzomib results in increased secretion of CKM protein] CTD PMID:26899300 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Coq4 coenzyme Q4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COQ4 mRNA CTD PMID:26873546 NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799 		JBrowse link
G Coq5 coenzyme Q5, methyltransferase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COQ5 mRNA CTD PMID:26873546 NCBI chr12:41,316,922...41,333,855
Ensembl chr12:41,316,748...41,333,848 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression
multiple interactions		 ISO Dexrazoxane results in increased expression of COX15 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX15 mRNA		 CTD PMID:26873546 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression ISO Dexrazoxane results in increased expression of COX17 mRNA CTD PMID:26873546 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO Dexrazoxane results in increased expression of COX4I1 mRNA CTD PMID:26873546 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 increases expression ISO Dexrazoxane results in increased expression of COX6B1 mRNA CTD PMID:26873546 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COX6C mRNA CTD PMID:26873546 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963 		JBrowse link
G Cox7b cytochrome c oxidase subunit 7B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COX7B mRNA CTD PMID:26873546 NCBI chr  X:71,083,486...71,089,733
Ensembl chr  X:71,083,456...71,089,732 		JBrowse link
G Cox7c cytochrome c oxidase subunit 7C affects expression ISO Dexrazoxane affects the expression of COX7C mRNA CTD PMID:26873546 NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760 		JBrowse link
G Cox8a cytochrome c oxidase subunit 8A increases expression ISO Dexrazoxane results in increased expression of COX8A mRNA CTD PMID:26873546 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Cox8c cytochrome c oxidase subunit 8C multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX8C mRNA CTD PMID:26873546 NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Dexrazoxane results in decreased expression of CPT1A mRNA CTD PMID:26873546 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression
multiple interactions		 ISO Dexrazoxane results in increased expression of CPT1C mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CPT1C mRNA		 CTD PMID:26873546 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression
multiple interactions		 ISO Dexrazoxane results in decreased expression of CPT2 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of CPT2 mRNA		 CTD PMID:26873546 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Crat carnitine O-acetyltransferase increases expression ISO Dexrazoxane results in increased expression of CRAT mRNA CTD PMID:26873546 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of CYCS mRNA CTD PMID:26873546 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CYP7B1 mRNA CTD PMID:26873546 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Dapl1 death associated protein-like 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAPL1 mRNA CTD PMID:26873546 NCBI chr 3:43,960,993...43,980,940
Ensembl chr 3:43,960,810...43,980,940 		JBrowse link
G Daxx death-domain associated protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAXX mRNA CTD PMID:26873546 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DBT mRNA CTD PMID:26873546 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DECR1 mRNA CTD PMID:26873546 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of DFFA mRNA CTD PMID:26873546 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DLST mRNA CTD PMID:26873546 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Dmac2l distal membrane arm assembly component 2 like multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DMAC2L mRNA CTD PMID:26873546 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933 		JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Dexrazoxane results in decreased expression of DNAJC19 mRNA CTD PMID:26873546 NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264 		JBrowse link
G Dpt dermatopontin multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of DPT protein CTD PMID:30517846 NCBI chr13:77,123,224...77,151,646
Ensembl chr13:77,123,115...77,151,639 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression
multiple interactions		 ISO Dexrazoxane results in increased expression of ECH1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ECH1 mRNA		 CTD PMID:26873546 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Exo1 exonuclease 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein] CTD PMID:28973540 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Faf1 Fas associated factor 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of FAF1 mRNA CTD PMID:26873546 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA CTD PMID:28973540 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Fh fumarate hydratase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of FH1 mRNA CTD PMID:26873546 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fstl3 follistatin like 3 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of FSTL3 protein CTD PMID:30517846 NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45A mRNA] CTD PMID:28973540 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA] CTD PMID:28973540 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Gcdh glutaryl-CoA dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of GCDH mRNA CTD PMID:26873546 NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
multiple interactions		 ISO Dexrazoxane results in decreased expression of GPAM mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of GPAM mRNA		 CTD PMID:26873546 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Dexrazoxane inhibits the reaction [Cyclophosphamide results in decreased expression of GPX4 protein] CTD PMID:37690746 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of GSTK1 mRNA CTD PMID:26873546 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Dexrazoxane inhibits the reaction [Cyclophosphamide results in increased expression of H2AX protein] CTD PMID:37690746 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Dexrazoxane results in decreased expression of HADH mRNA CTD PMID:26873546 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of HADHA mRNA CTD PMID:26873546 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase increases expression ISO Dexrazoxane results in increased expression of HMGCL mRNA CTD PMID:26873546 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression
multiple interactions		 ISO Dexrazoxane results in decreased expression of HMGCS2 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of HMGCS2 mRNA		 CTD PMID:26873546 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of HSD17B4 mRNA CTD PMID:26873546 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Iars2 isoleucyl-tRNA synthetase 2, mitochondrial multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IARS2 mRNA CTD PMID:26873546 NCBI chr13:96,831,484...96,865,518
Ensembl chr13:96,831,484...96,865,501 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IDH3A mRNA CTD PMID:26873546 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO Dexrazoxane results in decreased expression of IDH3B mRNA CTD PMID:26873546 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982 		JBrowse link
G Il18bp interleukin 18 binding protein multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of IL18BP protein] CTD PMID:30517846 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963 		JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IMMP2L mRNA CTD PMID:26873546 NCBI chr 6:58,070,035...58,970,165
Ensembl chr 6:58,070,283...58,969,840 		JBrowse link
G Ivd isovaleryl-CoA dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IVD mRNA CTD PMID:26873546 NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575 		JBrowse link
G Kif1b kinesin family member 1B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of KIF1B mRNA CTD PMID:26873546 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Dexrazoxane inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] CTD PMID:26899300 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MAOB mRNA CTD PMID:26873546 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MCCC2 mRNA CTD PMID:26873546 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972 		JBrowse link
G Mmut methylmalonyl-CoA mutase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MMUT mRNA CTD PMID:26873546 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MPC2 mRNA CTD PMID:26873546 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MRPL3 mRNA CTD PMID:26873546 NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544 		JBrowse link
G Mrpl50 mitochondrial ribosomal protein L50 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MRPL50 mRNA CTD PMID:26873546 NCBI chr 5:63,867,437...63,872,591 JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 decreases expression ISO Dexrazoxane results in decreased expression of ATP8 mRNA CTD PMID:26873546 NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 increases expression ISO Dexrazoxane results in increased expression of ND2 mRNA CTD PMID:26873546 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions ISO Dexrazoxane inhibits the reaction [carfilzomib results in decreased expression of MYH6 mRNA] CTD PMID:26899300 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Dexrazoxane inhibits the reaction [carfilzomib results in increased expression of MYH7 mRNA] CTD PMID:26899300 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nadk2 NAD kinase 2, mitochondrial multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NADK2 mRNA CTD PMID:26873546 NCBI chr 2:58,117,674...58,159,815
Ensembl chr 2:58,117,674...58,159,808 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA10 mRNA CTD PMID:26873546 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA2 mRNA CTD PMID:26873546 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA4 mRNA CTD PMID:26873546 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Dexrazoxane results in increased expression of NDUFA5 mRNA CTD PMID:26873546 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598 		JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 decreases expression
multiple interactions		 ISO Dexrazoxane results in decreased expression of NDUFA8 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA8 mRNA		 CTD PMID:26873546 NCBI chr 3:19,386,062...19,402,090
Ensembl chr 3:19,386,065...19,402,071 		JBrowse link
G Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of NDUFAF1 mRNA CTD PMID:26873546 NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212 		JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO Dexrazoxane results in increased expression of NDUFB2 mRNA CTD PMID:26873546 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851 		JBrowse link
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 increases expression
multiple interactions		 ISO Dexrazoxane results in increased expression of NDUFB4 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFB4 mRNA		 CTD PMID:26873546 NCBI chr11:63,063,723...63,070,426
Ensembl chr11:63,063,795...63,070,425 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 increases expression ISO Dexrazoxane results in increased expression of NDUFB7 mRNA CTD PMID:26873546 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Dexrazoxane results in decreased expression of NDUFB8 mRNA CTD PMID:26873546 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS2 mRNA CTD PMID:26873546 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS4 mRNA CTD PMID:26873546 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846 		JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 increases expression ISO Dexrazoxane results in increased expression of NDUFS6 mRNA CTD PMID:26873546 NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO Dexrazoxane results in increased expression of NDUFS7 mRNA CTD PMID:26873546 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression
multiple interactions		 ISO Dexrazoxane results in increased expression of NDUFV1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFV1 mRNA		 CTD PMID:26873546 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression ISO Dexrazoxane results in increased expression of NDUFV2 mRNA CTD PMID:26873546 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713 		JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of NOTCH1 protein] CTD PMID:30517846 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of OGDH mRNA CTD PMID:26873546 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression
multiple interactions		 ISO Dexrazoxane results in increased expression of OGG1 mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]		 CTD PMID:28973540 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein] CTD PMID:28973540 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdcd1 programmed cell death 1 decreases expression
multiple interactions		 ISO Dexrazoxane results in decreased expression of PDCD1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of PDCD1 mRNA		 CTD PMID:26873546 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Dexrazoxane results in decreased expression of PDCD4 mRNA CTD PMID:26873546 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pdcd6 programmed cell death 6 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA CTD PMID:26873546 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189 		JBrowse link
G Pdcd7 programmed cell death 7 decreases expression ISO Dexrazoxane results in decreased expression of PDCD7 mRNA CTD PMID:26873546 NCBI chr 8:65,862,606...65,877,333
Ensembl chr 8:65,862,387...65,877,333 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDK1 mRNA CTD PMID:26873546 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase decreases expression ISO Dexrazoxane results in decreased expression of PECR mRNA CTD PMID:26873546 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511 		JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PPM1K mRNA CTD PMID:26873546 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A protein] CTD PMID:28973540 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein] CTD PMID:28973540 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] CTD PMID:28973540 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA CTD PMID:28973540 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD9A mRNA] CTD PMID:28973540 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Ropn1 rhophilin associated tail protein 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ROPN1 mRNA CTD PMID:26873546 NCBI chr11:66,097,854...66,127,148
Ensembl chr11:66,097,856...66,127,148 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression ISO Dexrazoxane results in decreased expression of SDHB mRNA CTD PMID:26873546 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C affects expression ISO Dexrazoxane affects the expression of SDHC mRNA CTD PMID:26873546 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D decreases expression ISO Dexrazoxane results in decreased expression of SDHD mRNA CTD PMID:26873546 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Slc25a26 solute carrier family 25 member 26 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A26 mRNA CTD PMID:26873546 NCBI chr 4:127,036,704...127,131,026
Ensembl chr 4:127,036,742...127,131,020 		JBrowse link
G Slc25a3 solute carrier family 25 member 3 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A3 mRNA CTD PMID:26873546 NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A34 mRNA CTD PMID:26873546 NCBI chr 5:153,932,081...153,936,854 JBrowse link
G Slc25a42 solute carrier family 25, member 42 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A42 mRNA CTD PMID:26873546 NCBI chr16:19,213,914...19,251,990
Ensembl chr16:19,213,950...19,237,025 		JBrowse link
G Slc25a47 solute carrier family 25, member 47 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A47 mRNA CTD PMID:26873546 NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of SLC25A5 mRNA CTD PMID:26873546 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Cyclophosphamide results in decreased expression of SLC40A1 protein] CTD PMID:37690746 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO Dexrazoxane inhibits the reaction [Cyclophosphamide results in decreased expression of SLC7A11 protein] CTD PMID:37690746 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Spata19 spermatogenesis associated 19 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of SPATA19 mRNA CTD PMID:26873546 NCBI chr 8:25,814,922...25,820,663
Ensembl chr 8:25,814,905...25,820,670 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of STAR mRNA CTD PMID:26873546 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SUCLA2 mRNA CTD PMID:26873546 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138 		JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TERF1 mRNA] CTD PMID:28973540 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in increased expression of TNNI3 protein CTD PMID:30517846 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein] CTD PMID:26873546 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Dexrazoxane analog results in decreased activity of TOP2A protein; Dexrazoxane results in decreased activity of TOP2A protein CTD PMID:28941780 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta decreases expression
increases degradation		 EXP Dexrazoxane analog results in decreased expression of TOP2B protein; Dexrazoxane results in decreased expression of TOP2B protein
Dexrazoxane results in increased degradation of TOP2B protein		 CTD PMID:28941780 PMID:38290791 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 multiple interactions
decreases expression		 ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]
Dexrazoxane results in decreased expression of TOPBP1 mRNA		 CTD PMID:28973540 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP		 Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA]
Dexrazoxane inhibits the reaction [Daunorubicin results in increased phosphorylation of TP53 protein]		 CTD PMID:28973540 PMID:38290791 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tspo translocator protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of TSPO mRNA CTD PMID:26873546 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Ucp3 uncoupling protein 3 decreases expression ISO Dexrazoxane results in decreased expression of UCP3 mRNA CTD PMID:26873546 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of UNG mRNA] CTD PMID:28973540 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCR10 mRNA CTD PMID:26873546 NCBI chr14:79,566,151...79,569,017
Ensembl chr14:79,566,157...79,569,003 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI increases expression ISO Dexrazoxane results in increased expression of UQCR11 mRNA CTD PMID:26873546 NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750 		JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein increases expression ISO Dexrazoxane results in increased expression of UQCRB mRNA CTD PMID:26873546 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions
decreases expression		 ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCRFS1 mRNA
Dexrazoxane results in decreased expression of UQCRFS1 mRNA		 CTD PMID:26873546 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein increases expression ISO Dexrazoxane results in increased expression of UQCRH mRNA CTD PMID:26873546 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCRQ mRNA CTD PMID:26873546 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in increased expression of VWF protein; Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of VWF protein] CTD PMID:30517846 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA CTD PMID:28973540 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein] CTD PMID:28973540 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA CTD PMID:28973540 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
G Yars2 tyrosyl-tRNA synthetase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of YARS2 mRNA CTD PMID:26873546 NCBI chr11:84,632,350...84,638,138
Ensembl chr11:84,624,369...84,638,125 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        immunomodulator 15081
          immunosuppressive agent 13924
            (+)-dexrazoxane 176
              dexrazoxane hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          N-alkylpiperazine 3404
                                            razoxane 220
                                              (+)-dexrazoxane 176
                                                dexrazoxane hydrochloride 0
paths to the root