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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naringenin
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Accession:CHEBI:50202 term browser browse the term
Definition:A trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 6 and 4'.
Synonyms:related_synonym: 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
 xref: Beilstein:280888;   lincs.smallmolecule:LSM-1927;   metacyc.compound:Naringenin
 chemrof_formula: C15H12O5
 chemrof_inchikey: FTVWIRXFELQLPI-UHFFFAOYSA-N
 chemrof_inchi: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2
 chemrof_smiles: O=C1CC(c2ccc(O)cc2)Oc2cc(O)cc(O)c21


show annotations for term's descendants           Sort by:
naringenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Naringenin increases expression of NR1H3 mRNA and protein in macrophages RGD PMID:29140707 RGD:401842389 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
(S)-naringenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions 		ISO naringenin results in increased expression of ABCB1 mRNA
naringenin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; naringenin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] 		CTD PMID:19148864 PMID:34217736 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases activity 		ISO [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione] CTD PMID:11306701 PMID:12485947 PMID:16156793 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] CTD PMID:16156793 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP naringenin inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:14709902 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA
naringenin metabolite results in increased expression of ADGRB1 mRNA 		CTD PMID:36235125 NCBI chr 7:108,293,681...108,365,892
Ensembl chr 7:108,293,818...108,365,870 		JBrowse link
G Afp alpha-fetoprotein affects binding EXP naringenin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions 		ISO naringenin results in increased activity of AHR protein
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] 		CTD PMID:17869316 PMID:20450880 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions ISO naringenin binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO naringenin results in decreased activity of AKR1C3 protein CTD PMID:19007764 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression 		ISO
EXP 		naringenin inhibits the reaction [bisphenol A results in increased activity of AKT1 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
naringenin inhibits the reaction [lead acetate results in decreased expression of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]
naringenin results in decreased expression of AKT1 mRNA 		CTD PMID:22692793 PMID:22709785 PMID:25866363 PMID:36807407 PMID:36819991 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alb albumin multiple interactions ISO naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA] CTD PMID:31063766 PMID:37076581 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] CTD PMID:12650720 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of APAF1 mRNA; naringenin results in increased expression of APAF1 protein
[naringenin co-treated with bisphenol A] results in increased expression of APAF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of APAF1 mRNA 		CTD PMID:27838343 PMID:36235125 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15030205 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO naringenin results in increased expression of ARHGDIA mRNA; naringenin results in increased expression of ARHGDIA protein CTD PMID:27838343 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] 		CTD PMID:20450880 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of ATM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATM mRNA CTD PMID:36235125 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of ATR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATR mRNA CTD PMID:36235125 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718 		JBrowse link
G Bace1 beta-secretase 1 decreases activity ISO naringenin results in decreased activity of BACE1 protein CTD PMID:31194956 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO naringenin results in increased expression of BAK1 protein CTD PMID:27838343 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein]
naringenin results in decreased expression of BAX mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of BAX mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; naringenin inhibits the reaction [Tamoxifen results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [naringenin results in decreased expression of BAX mRNA] 		CTD PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of BBC3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BBC3 mRNA CTD PMID:36235125 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein] CTD PMID:23085349 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
decreases expression 		ISO
EXP 		[naringenin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2 mRNA; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin]; naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]
naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
naringenin results in decreased expression of BCL2 mRNA 		CTD PMID:19124070 PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of BCL2A1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA 		CTD PMID:36235125 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO naringenin results in decreased expression of BCL2L1 protein CTD PMID:27838343 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression 		EXP naringenin inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]
naringenin results in increased expression of BDNF mRNA 		CTD PMID:34655599 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of BIRC5 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BIRC5 mRNA
naringenin metabolite results in increased expression of BIRC5 mRNA 		CTD PMID:36235125 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNA CTD PMID:36235125 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Brca2 BRCA2, DNA repair associated increases expression
multiple interactions 		ISO naringenin results in increased expression of BRCA2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BRCA2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA2 mRNA 		CTD PMID:36235125 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression
multiple interactions 		ISO naringenin metabolite results in decreased expression of BTG2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BTG2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BTG2 mRNA 		CTD PMID:36235125 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Casp2 caspase 2 multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of CASP2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP2 mRNA
naringenin results in increased expression of CASP2 mRNA 		CTD PMID:36235125 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression 		ISO
EXP 		naringenin results in increased activity of CASP3 protein
naringenin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]; naringenin inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; naringenin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
naringenin results in increased expression of CASP3 protein modified form
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
naringenin results in increased expression of CASP3 mRNA 		CTD PMID:19124070 PMID:22692793 PMID:23192364 PMID:27838343 PMID:31254498 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases expression ISO naringenin results in increased expression of CASP7 protein modified form CTD PMID:27838343 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases expression 		ISO
EXP 		naringenin results in increased activity of CASP9 protein
naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP9 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP9 mRNA]
naringenin metabolite results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 protein modified form
[naringenin co-treated with bisphenol A] results in increased expression of CASP9 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP9 mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein] 		CTD PMID:19124070 PMID:23192364 PMID:27838343 PMID:31254498 PMID:36235125 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
increases activity
decreases expression 		EXP
ISO 		naringenin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; naringenin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of CAT protein]; naringenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; naringenin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringenin inhibits the reaction [Glucose results in decreased activity of CAT protein]; naringenin inhibits the reaction [lead acetate results in decreased activity of CAT protein]; naringenin inhibits the reaction [Paraquat results in increased activity of CAT protein]; naringenin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
naringenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
naringenin analog results in increased activity of CAT protein; naringenin results in increased activity of CAT protein
naringenin results in decreased expression of CAT protein
naringenin inhibits the reaction [Trichloroethylene results in decreased activity of CAT protein] 		CTD PMID:19063931 PMID:19409769 PMID:23192364 PMID:23283742 PMID:23845967 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNB1 mRNA CTD PMID:36235125 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO [Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNA
naringenin results in decreased expression of CCND1 mRNA 		CTD PMID:30153467 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions 		ISO naringenin results in decreased expression of CCNE1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of CCNE1 mRNA 		CTD PMID:30153467 PMID:36235125 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in decreased expression of CCNG1 mRNA CTD PMID:36235125 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Ccnh cyclin H multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNH mRNA CTD PMID:36235125 NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860 		JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of CDC25A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25A mRNA
naringenin metabolite results in increased expression of CDC25A mRNA 		CTD PMID:36235125 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of CDC25C mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25C mRNA CTD PMID:36235125 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in decreased expression of CDK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDK1 mRNA CTD PMID:36235125 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of CDK4 mRNA CTD PMID:36235125 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of CDKN1A mRNA
naringenin metabolite results in increased expression of CDKN1A mRNA; naringenin results in increased expression of CDKN1A mRNA 		CTD PMID:30153467 PMID:36235125 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of CDKN2A mRNA CTD PMID:36235125 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of CHEK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK1 mRNA CTD PMID:36235125 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA CTD PMID:36235125 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP naringenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of CRADD mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CRADD mRNA
naringenin results in increased expression of CRADD mRNA 		CTD PMID:36235125 NCBI chr 7:31,827,131...31,839,796
Ensembl chr 7:31,685,622...31,874,512 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions 		EXP naringenin results in decreased expression of CTNNB1 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA] 		CTD PMID:34655599 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA CTD PMID:24586459 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression 		EXP
ISO 		naringenin inhibits the reaction [Glucose affects the localization of CYCS protein]
naringenin results in increased expression of CYCS protein 		CTD PMID:23192364 PMID:27838343 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity 		ISO
EXP 		naringenin binds to and results in decreased activity of CYP19A1 protein
naringenin results in decreased activity of CYP19A1 protein 		CTD PMID:9435150 PMID:15319488 PMID:17895526 PMID:38403145 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression 		ISO
EXP 		naringenin binds to and results in decreased activity of CYP1A1 protein; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
naringenin results in decreased activity of CYP1A1 protein
naringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
naringenin results in increased expression of CYP1A1 mRNA 		CTD PMID:11454723 PMID:20930378 PMID:21053930 PMID:27444380 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO naringenin results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:29753067 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression 		ISO naringenin binds to and results in decreased activity of CYP1B1 protein
naringenin results in increased expression of CYP1B1 mRNA 		CTD PMID:21053930 PMID:31621310 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO naringenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO
EXP 		naringenin results in decreased activity of CYP2E1 protein CTD PMID:33007396 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression 		ISO naringenin results in decreased activity of CYP3A4 protein
naringenin results in increased expression of CYP3A4 mRNA 		CTD PMID:19148864 PMID:21053930 PMID:29753067 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of DNMT1 mRNA CTD PMID:36235125 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression
multiple interactions 		EXP naringenin results in decreased expression of DRD2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of DRD2 mRNA] 		CTD PMID:34655599 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of E2F1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F1 mRNA CTD PMID:36235125 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of E2F3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F3 mRNA CTD PMID:36235125 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of EGFR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGFR mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein] CTD PMID:25866363 PMID:36235125 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of EGR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGR1 mRNA CTD PMID:36235125 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding
decreases expression
increases expression 		ISO
EXP 		[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein
naringenin results in increased activity of ESR1 protein
naringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative form
naringenin metabolite results in increased expression of ESR1 mRNA; naringenin results in increased expression of ESR1 mRNA 		CTD PMID:9751507 PMID:10397250 PMID:10854714 PMID:12650720 PMID:15713566 More... NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
increases activity
increases expression 		ISO
EXP 		[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; bisphenol A inhibits the reaction [naringenin metabolite results in increased expression of ESR2 mRNA]; bisphenol A inhibits the reaction [naringenin results in increased expression of ESR2 mRNA]; naringenin binds to and results in increased activity of ESR2 protein; naringenin inhibits the reaction [Estradiol binds to ESR2 protein]
naringenin binds to ESR2 protein
naringenin results in increased activity of ESR2 protein
naringenin metabolite results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 protein 		CTD PMID:9751507 PMID:12224631 PMID:16118406 PMID:16566672 PMID:17716812 More... NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of FADD mRNA CTD PMID:36235125 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of FAS mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FAS mRNA
naringenin metabolite results in increased expression of FAS mRNA 		CTD PMID:36235125 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of FASLG mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FASLG mRNA
naringenin metabolite results in increased expression of FASLG mRNA 		CTD PMID:36235125 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO naringenin results in increased expression of FOS mRNA CTD PMID:28395574 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of FOXO3 mRNA CTD PMID:36235125 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions
decreases activity 		EXP
ISO 		[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein]
naringenin results in decreased activity of G6PD protein 		CTD PMID:19063931 PMID:25130191 PMID:25228019 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of GADD45A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GADD45A mRNA
naringenin metabolite results in increased expression of GADD45A mRNA 		CTD PMID:36235125 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression 		ISO NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein] CTD PMID:31254498 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions 		ISO naringenin results in increased expression of GCLM protein
NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein] 		CTD PMID:31254498 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gml glycosylphosphatidylinositol anchored molecule like increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of GML mRNA
[naringenin co-treated with bisphenol A] results in increased expression of GML mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GML mRNA 		CTD PMID:36235125 NCBI chr 7:108,578,386...108,601,738 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
decreases expression 		ISO [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein
naringenin metabolite results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 protein 		CTD PMID:30153467 PMID:36235125 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [naringenin co-treated with methylmercuric chloride] results in decreased activity of GPT protein; naringenin inhibits the reaction [Arsenic Trioxide results in increased activity of GPT protein]; naringenin inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:23283742 PMID:29223569 PMID:38308452 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression 		EXP
ISO 		naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA]
naringenin results in decreased expression of GPX1 protein 		CTD PMID:23192364 PMID:28395574 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
increases expression 		ISO [Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA
naringenin results in increased expression of GPX2 mRNA 		CTD PMID:24561720 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA CTD PMID:24561720 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression
multiple interactions 		ISO naringenin results in increased expression of GPX5 mRNA
[Paraquat co-treated with naringenin] results in increased expression of GPX5 mRNA 		CTD PMID:24561720 NCBI chr17:48,131,853...48,138,801
Ensembl chr17:48,093,895...48,138,801 		JBrowse link
G Gpx7 glutathione peroxidase 7 multiple interactions
increases expression 		ISO [Paraquat co-treated with naringenin] results in increased expression of GPX7 mRNA
naringenin results in increased expression of GPX7 mRNA 		CTD PMID:24561720 NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:128,372,875...128,381,725 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression 		EXP
ISO 		naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; naringenin inhibits the reaction [Glucose results in decreased expression of GSR mRNA]
Paraquat inhibits the reaction [naringenin results in increased expression of GSR mRNA] 		CTD PMID:19063931 PMID:23192364 PMID:24561720 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 multiple interactions
increases expression 		ISO Paraquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA] CTD PMID:24561720 NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:112,525,377...112,536,233 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein] CTD PMID:23845967 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hk2 hexokinase 2 increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of HK2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of HK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of HK2 mRNA 		CTD PMID:36235125 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		EXP
ISO 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin results in increased expression of and results in increased activity of HMOX1 protein; wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]
naringenin results in increased expression of HMOX1 mRNA
naringenin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]
[Paraquat co-treated with naringenin] results in increased expression of HMOX1 mRNA
naringenin results in increased expression of HMOX1 mRNA; naringenin results in increased expression of HMOX1 protein 		CTD PMID:15316927 PMID:22709785 PMID:24561720 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of IGF1R mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IGF1R mRNA CTD PMID:36235125 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases expression ISO naringenin results in increased expression of IKBKB mRNA CTD PMID:28395574 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO 		naringenin inhibits the reaction [lead acetate results in increased expression of IL1B protein]
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] 		CTD PMID:36807407 PMID:37880698 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of IL6 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of IL6 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IL6 mRNA
naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA] 		CTD PMID:36235125 PMID:37076581 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions EXP naringenin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; naringenin inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]; naringenin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein] CTD PMID:36731809 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression 		ISO naringenin metabolite results in decreased expression of JUN mRNA; naringenin results in decreased expression of JUN mRNA
naringenin results in increased expression of JUN mRNA 		CTD PMID:28395574 PMID:36235125 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of KAT2B mRNA
[naringenin co-treated with bisphenol A] results in increased expression of KAT2B mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of KAT2B mRNA 		CTD PMID:36235125 NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,799,145...6,903,616 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity 		ISO Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein] CTD PMID:18057881 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP naringenin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein] CTD PMID:36731809 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of KRAS mRNA CTD PMID:36235125 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP naringenin inhibits the reaction [lead acetate results in decreased expression of LHB protein] CTD PMID:36807407 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Lpo lactoperoxidase increases expression
multiple interactions 		ISO naringenin results in increased expression of LPO mRNA
Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA] 		CTD PMID:24561720 NCBI chr10:73,104,170...73,124,683
Ensembl chr10:73,104,188...73,123,456 		JBrowse link
G Lrrc27 leucine rich repeat containing 27 increases expression ISO naringenin results in increased expression of LRRC27 mRNA; naringenin results in increased expression of LRRC27 protein CTD PMID:27838343 NCBI chr 1:203,433,463...203,464,683
Ensembl chr 1:203,434,355...203,464,676 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 decreases expression
multiple interactions 		EXP naringenin results in decreased expression of LRRK2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of LRRK2 mRNA] 		CTD PMID:34655599 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases expression ISO naringenin results in increased expression of MAP3K5 protein CTD PMID:27838343 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases activity
decreases phosphorylation 		EXP
ISO 		naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
naringenin results in decreased expression of MAPK1 mRNA
naringenin results in decreased activity of MAPK1 protein
naringenin results in decreased phosphorylation of MAPK1 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein] 		CTD PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
decreases activity 		EXP
ISO 		naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
naringenin results in decreased phosphorylation of MAPK3 protein
naringenin results in decreased activity of MAPK3 protein 		CTD PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO naringenin results in increased phosphorylation of MAPK8 protein CTD PMID:27838343 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO naringenin results in increased phosphorylation of MAPK9 protein CTD PMID:27838343 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of MCL1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MCL1 mRNA CTD PMID:36235125 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mdk midkine multiple interactions EXP naringenin inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein] CTD PMID:36731809 NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM2 mRNA
naringenin metabolite results in increased expression of MDM2 mRNA 		CTD PMID:36235125 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of MDM4 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM4 mRNA CTD PMID:36235125 NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372 		JBrowse link
G Mir141 microRNA 141 decreases expression ISO naringenin metabolite results in decreased expression of MIR141 mRNA CTD PMID:36235125 NCBI chr 4:159,209,525...159,209,618 JBrowse link
G Mir200c microRNA 200c multiple interactions ISO naringenin inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA]; naringenin metabolite inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA] CTD PMID:36235125 NCBI chr 4:159,209,965...159,210,033 JBrowse link
G Mlh1 mutL homolog 1 increases expression
multiple interactions 		ISO naringenin results in increased expression of MLH1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MLH1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MLH1 mRNA 		CTD PMID:36235125 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions 		ISO naringenin results in decreased expression of MMP2 mRNA
naringenin results in decreased expression of and results in decreased activity of MMP2 protein 		CTD PMID:30153467 PMID:30431227 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression 		ISO naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringenin results in decreased expression of and results in decreased activity of MMP9 protein
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]
naringenin results in decreased expression of MMP9 mRNA 		CTD PMID:25866363 PMID:30153467 PMID:30431227 PMID:37880698 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of MSH2 mRNA CTD PMID:36235125 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP naringenin inhibits the reaction [lead acetate results in decreased expression of MTOR protein] CTD PMID:36807407 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myod1 myogenic differentiation 1 increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of MYOD1 mRNA; naringenin results in increased expression of MYOD1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MYOD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MYOD1 mRNA 		CTD PMID:36235125 NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO naringenin results in decreased expression of NANOG protein CTD PMID:27468969 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Nf1 neurofibromin 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of NF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NF1 mRNA CTD PMID:36235125 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
increases expression 		ISO [naringenin co-treated with Paraquat] results in increased expression of NFE2L2 protein; naringenin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]
naringenin results in increased activity of NFE2L2 protein
naringenin results in increased expression of NFE2L2 mRNA 		CTD PMID:24561720 PMID:31254498 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of NFKB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NFKB1 mRNA CTD PMID:36235125 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO naringenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:10188978 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfkbil1 NFKB inhibitor like 1 increases expression ISO naringenin results in increased expression of NFKBIL1 mRNA; naringenin results in increased expression of NFKBIL1 protein CTD PMID:27838343 NCBI chr20:3,595,319...3,610,295
Ensembl chr20:3,595,284...3,610,294 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO naringenin results in increased expression of NME1 mRNA; naringenin results in increased expression of NME1 protein CTD PMID:27838343 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:10188978 PMID:12512693 PMID:15316927 PMID:18274639 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression 		ISO [Paraquat co-treated with naringenin] results in increased expression of NQO1 mRNA
naringenin results in increased expression of NQO1 mRNA; naringenin results in increased expression of NQO1 protein 		CTD PMID:24561720 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO naringenin results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions 		ISO naringenin results in increased cleavage of PARP1 protein
naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] 		CTD PMID:27838343 PMID:31254498 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of PCNA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PCNA mRNA CTD PMID:36235125 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO naringenin results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions 		EXP
ISO 		naringenin results in increased expression of PGR mRNA
[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA 		CTD PMID:10397250 PMID:24586459 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of PIDD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PIDD1 mRNA CTD PMID:36235125 NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600 		JBrowse link
G Pon1 paraoxonase 1 increases expression ISO naringenin results in increased expression of PON1 mRNA CTD PMID:15169886 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO 		HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein] 		CTD PMID:31063766 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO
EXP 		naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARB protein]
HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein] 		CTD PMID:31063766 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO 		HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein] 		CTD PMID:29223569 PMID:31063766 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of PPM1D mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PPM1D mRNA CTD PMID:36235125 NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256 		JBrowse link
G Prdx1 peroxiredoxin 1 decreases expression ISO naringenin results in decreased expression of PRDX1 mRNA; naringenin results in decreased expression of PRDX1 protein CTD PMID:27838343 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of PRKCA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PRKCA mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] CTD PMID:25866363 PMID:36235125 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein] CTD PMID:25866363 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCG protein] CTD PMID:25866363 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
G Prom1 prominin 1 decreases expression ISO naringenin results in decreased expression of PROM1 protein CTD PMID:27468969 NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002 		JBrowse link
G Psen2 presenilin 2 multiple interactions ISO [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA CTD PMID:24586459 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression 		ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of PTEN mRNA
naringenin results in increased expression of PTEN mRNA 		CTD PMID:36235125 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO naringenin results in increased expression of PTGS1 mRNA CTD PMID:24561720 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP 		naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringenin inhibits the reaction [Trichloroethylene results in increased expression of PTGS2 protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein] 		CTD PMID:21341175 PMID:25855085 PMID:27206700 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of PTTG1 mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTTG1 mRNA 		CTD PMID:36235125 NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of RB1 mRNA CTD PMID:36235125 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		naringenin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
naringenin inhibits the reaction [Trichloroethylene results in increased expression of RELA protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]; naringenin inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein] 		CTD PMID:18274639 PMID:25855085 PMID:27206700 PMID:36731809 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of RPRM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of RPRM mRNA
naringenin metabolite results in increased expression of RPRM mRNA; naringenin results in increased expression of RPRM mRNA 		CTD PMID:36235125 NCBI chr 3:58,948,618...58,950,035
Ensembl chr 3:58,799,866...58,950,542 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 increases expression ISO naringenin results in increased expression of RPTOR mRNA; naringenin results in increased expression of RPTOR protein CTD PMID:27838343 NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:22709785 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of SESN2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SESN2 mRNA CTD PMID:36235125 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO naringenin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760 		JBrowse link
G Si sucrase-isomaltase decreases activity
multiple interactions 		EXP
ISO 		naringenin results in decreased activity of SI protein
naringenin binds to and results in decreased activity of SI protein 		CTD PMID:24412302 NCBI chr 2:159,804,568...159,884,902
Ensembl chr 2:159,804,568...159,883,934 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIAH1 mRNA CTD PMID:36235125 NCBI chr19:36,552,165...36,575,773
Ensembl chr19:36,540,947...36,581,541 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of SIRT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIRT1 mRNA CTD PMID:36235125 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO
EXP 		naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]
[naringenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate 		CTD PMID:17108059 PMID:17976262 NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity 		ISO naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
naringenin results in decreased activity of SLC2A1 protein 		CTD PMID:14642735 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:29223569 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO naringenin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
multiple interactions 		EXP naringenin results in decreased expression of SLC6A3 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of SLC6A3 mRNA] 		CTD PMID:34655599 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO naringenin results in decreased expression of SNAI1 protein CTD PMID:30431227 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO naringenin results in decreased expression of SNAI2 protein CTD PMID:30431227 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349 		JBrowse link
G Snca synuclein alpha multiple interactions
increases expression 		EXP naringenin inhibits the reaction [Paraquat results in increased expression of SNCA mRNA]
naringenin results in increased expression of SNCA mRNA 		CTD PMID:34655599 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO naringenin results in increased expression of SOCS3 mRNA CTD PMID:23782265 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression 		EXP
ISO 		naringenin inhibits the reaction [Glucose results in increased expression of SOD1 mRNA]
naringenin results in decreased expression of SOD1 protein 		CTD PMID:23192364 PMID:28395574 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP naringenin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA] CTD PMID:23192364 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO naringenin results in decreased expression of SOX2 protein CTD PMID:27468969 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA] CTD PMID:22709785 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in decreased expression of STAT1 mRNA CTD PMID:36235125 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO naringenin results in decreased phosphorylation of STAT3 protein CTD PMID:27468969 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO
EXP 		Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin] CTD PMID:11181495 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Tada3 transcriptional adaptor 3 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in decreased expression of TADA3 mRNA CTD PMID:36235125 NCBI chr 4:148,065,859...148,077,347
Ensembl chr 4:148,065,877...148,077,320 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP naringenin inhibits the reaction [ITGA4 protein results in increased expression of TEK protein] CTD PMID:36731809 NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP 		naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
naringenin inhibits the reaction [lead acetate results in increased expression of TGFB1 protein] 		CTD PMID:23845967 PMID:36807407 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression 		EXP naringenin inhibits the reaction [Paraquat results in decreased expression of TH protein]
naringenin results in decreased expression of TH protein 		CTD PMID:34655599 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
increases expression 		ISO
EXP 		[naringenin co-treated with bisphenol A] results in increased expression of TNF mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TNF mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
naringenin inhibits the reaction [lead acetate results in increased expression of TNF protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]
naringenin metabolite results in increased expression of TNF mRNA 		CTD PMID:18720166 PMID:19135038 PMID:22709785 PMID:36235125 PMID:36807407 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO [Tamoxifen co-treated with naringenin] results in increased expression of TP53 mRNA; naringenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]; naringenin results in increased expression of and results in increased phosphorylation of TP53 protein
naringenin results in increased expression of TP53 mRNA 		CTD PMID:15795422 PMID:27838343 PMID:30153467 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP53BP2 mRNA CTD PMID:36235125 NCBI chr13:96,620,429...96,677,090
Ensembl chr13:96,620,428...96,677,616 		JBrowse link
G Tp63 tumor protein p63 multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of TP63 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP63 mRNA
naringenin metabolite results in increased expression of TP63 mRNA; naringenin results in increased expression of TP63 mRNA 		CTD PMID:36235125 NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177 		JBrowse link
G Tp73 tumor protein p73 increases expression
multiple interactions 		ISO naringenin metabolite results in increased expression of TP73 mRNA; naringenin results in increased expression of TP73 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of TP73 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP73 mRNA 		CTD PMID:36235125 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP naringenin results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of TRAF2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TRAF2 mRNA CTD PMID:36235125 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691 		JBrowse link
G Tsc1 TSC complex subunit 1 multiple interactions ISO [naringenin co-treated with bisphenol A] results in increased expression of TSC1 mRNA CTD PMID:36235125 NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:32,367,670...32,416,568 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP naringenin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
increases expression 		ISO UGT1A1 protein results in increased glucuronidation of naringenin
naringenin results in increased expression of UGT1A1 mRNA 		CTD PMID:14557274 PMID:31621310 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of naringenin CTD PMID:14557274 PMID:18816295 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of naringenin CTD PMID:7574722 NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP 		naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]
naringenin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein] 		CTD PMID:36731809 PMID:37076581 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions
increases expression 		ISO [naringenin co-treated with bisphenol A] results in increased expression of WT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of WT1 mRNA
naringenin metabolite results in increased expression of WT1 mRNA 		CTD PMID:36235125 NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP naringenin inhibits the reaction [Benzo(a)pyrene results in increased activity of XDH protein] CTD PMID:27206700 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 multiple interactions ISO [naringenin metabolite co-treated with bisphenol A] results in decreased expression of XRCC5 mRNA CTD PMID:36235125 NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      molecular entity 20871
        polyatomic entity 20745
          heteroatomic molecular entity 20606
            hydroxides 19922
              organic hydroxy compound 19685
                hydroxyflavanone 579
                  4'-hydroxyflavanones 373
                    naringenin 204
                      (R)-naringenin 0
                      (S)-naringenin 203
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  oxacycle 18273
                                    benzopyran 10790
                                      1-benzopyran 10376
                                        flavans 3662
                                          flavanones 597
                                            hydroxyflavanone 579
                                              4'-hydroxyflavanones 373
                                                naringenin 204
                                                  (R)-naringenin 0
                                                  (S)-naringenin 203
paths to the root