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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydroxybenzaldehyde
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Accession:CHEBI:50196 term browser browse the term
Definition:Any member of the class of benzaldehydes in which the phenyl ring is substituted by two hydroxy groups.
Synonyms:related_synonym: Formula=C7H6O3



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2,5-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde CTD PMID:11744614 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
3,4-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of ACHE protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein] CTD PMID:29665407 PMID:29732668 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:25582705 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO
EXP
protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]
CTD PMID:17597607 PMID:25582705 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Cat catalase multiple interactions
increases activity
ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
protocatechualdehyde results in increased activity of CAT protein
CTD PMID:29665407 PMID:29732668 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:25582705 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein]
CTD PMID:25582705 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of G6PD protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein] CTD PMID:29665407 PMID:29732668 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [sodium arsenite results in increased activity of GLO1 protein] CTD PMID:29732668 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:29665407 PMID:29732668 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]
CTD PMID:25582705 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:17597607 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in increased activity of SOD1 protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein] CTD PMID:29665407 PMID:29732668 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:17597607 PMID:25582705 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Vim vimentin multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:25582705 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        solvent 17232
          formic acid 9094
            formyl group 9051
              aldehyde 9051
                arenecarbaldehyde 139
                  benzaldehydes 136
                    dihydroxybenzaldehyde 17
                      2,3-dihydroxybenzaldehyde 0
                      2,4-dihydroxy-3,5,6-trimethylbenzaldehyde 0
                      2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 0
                      2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde 0
                      2,4-dihydroxy-5,6-dimethylbenzaldehyde 0
                      2,4-dihydroxy-6-methylbenzaldehyde 0
                      2,4-dihydroxybenzaldehyde 0
                      2,5-dihydroxybenzaldehyde 1
                      2,6-dihydroxybenzaldehyde 0
                      3,4-dihydroxybenzaldehyde 16
                      3,5-dihydroxybenzaldehyde 0
                      6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde 0
                      6-ethyl-2,4-dihydroxy-3,5-dimethylbenzaldehyde 0
                      FK17-P2a 0
                      ascochlorin 0
                      ascofuranol 0
                      ascofuranone 0
                      guangsangon L 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          formyl group 9051
                                            aldehyde 9051
                                              arenecarbaldehyde 139
                                                benzaldehydes 136
                                                  dihydroxybenzaldehyde 17
                                                    2,3-dihydroxybenzaldehyde 0
                                                    2,4-dihydroxy-3,5,6-trimethylbenzaldehyde 0
                                                    2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 0
                                                    2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde 0
                                                    2,4-dihydroxy-5,6-dimethylbenzaldehyde 0
                                                    2,4-dihydroxy-6-methylbenzaldehyde 0
                                                    2,4-dihydroxybenzaldehyde 0
                                                    2,5-dihydroxybenzaldehyde 1
                                                    2,6-dihydroxybenzaldehyde 0
                                                    3,4-dihydroxybenzaldehyde 16
                                                    3,5-dihydroxybenzaldehyde 0
                                                    6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde 0
                                                    6-ethyl-2,4-dihydroxy-3,5-dimethylbenzaldehyde 0
                                                    FK17-P2a 0
                                                    ascochlorin 0
                                                    ascofuranol 0
                                                    ascofuranone 0
                                                    guangsangon L 0
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