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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deptropine
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Accession:CHEBI:50189 term browser browse the term
Definition:An azabicycloalkane that is the 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl ether of tropine.
Synonyms:exact_synonym: (3-endo)-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)-8-methyl-8-azabicyclo[3.2.1]octane
 related_synonym: Formula=C23H27NO;   InChI=1S/C23H27NO/c1-24-18-12-13-19(24)15-20(14-18)25-23-21-8-4-2-6-16(21)10-11-17-7-3-5-9-22(17)23/h2-9,18-20,23H,10-15H2,1H3/t18-,19+,20+;   InChIKey=ZWPODSUQWXAZNC-PMOLBWCYSA-N;   SMILES=CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC1c2ccccc2CCc2ccccc12;   deptropina;   deptropinum;   dibenzheptropine;   endo-3-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-1alphaH,5alphaH-tropane;   endo-3-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane
 xref: Beilstein:1437981;   CAS:604-51-3;   Drug_Central:808;   KEGG:D07404
 xref_mesh: MESH:C100220
 xref: Reaxys:13497401


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deptropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO dibenzheptropine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        pharmacological role 19069
          antagonist 17240
            histamine antagonist 4893
              H1-receptor antagonist 4146
                deptropine 1
                  deptropine citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            organic molecule 19692
                              organic cyclic compound 19482
                                organic heterocyclic compound 18872
                                  organic heteropolycyclic compound 18301
                                    organic heterobicyclic compound 17244
                                      azabicycloalkane 3466
                                        tropane alkaloid 1579
                                          tropine 115
                                            deptropine 1
                                              deptropine citrate 0
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