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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
increases reduction affects metabolic processing |
ISO |
AKR1C1 protein results in increased reduction of Pregnanolone AKR1C1 protein affects the metabolism of Pregnanolone |
CTD |
PMID:11995921 PMID:12604236 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases reduction affects metabolic processing |
ISO |
AKR1C2 protein results in increased reduction of Pregnanolone AKR1C2 protein affects the metabolism of Pregnanolone |
CTD |
PMID:11995921 PMID:12604236 |
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NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
increases chemical synthesis |
ISO |
AKR1C3 protein results in increased chemical synthesis of Pregnanolone |
CTD |
PMID:25463305 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Crh |
corticotropin releasing hormone |
affects expression multiple interactions |
EXP |
Pregnanolone affects the expression of CRH mRNA Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein] |
CTD |
PMID:7816204 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases hydroxylation |
ISO |
CYP17A1 protein results in increased hydroxylation of Pregnanolone analog |
CTD |
PMID:14522586 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Egr2 |
early growth response 2 |
increases expression |
EXP |
Pregnanolone results in increased expression of EGR2 mRNA; Pregnanolone results in increased expression of EGR2 protein |
CTD |
PMID:17478888 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
multiple interactions |
ISO |
Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form] |
CTD |
PMID:29038840 |
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NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gabra2 |
gamma-aminobutyric acid type A receptor subunit alpha 2 |
multiple interactions |
ISO |
Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] |
CTD |
PMID:29038840 |
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NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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G |
Gabra4 |
gamma-aminobutyric acid type A receptor subunit alpha 4 |
increases expression multiple interactions |
EXP ISO |
Pregnanolone deficiency results in increased expression of GABRA4 mRNA; Pregnanolone deficiency results in increased expression of GABRA4 protein Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein] |
CTD |
PMID:9651210 PMID:29038840 |
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NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
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G |
Gabra6 |
gamma-aminobutyric acid type A receptor subunit alpha6 |
increases response to substance multiple interactions |
ISO |
GABRA6 protein results in increased susceptibility to Pregnanolone Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] |
CTD |
PMID:9281599 PMID:29038840 |
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NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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G |
Gabrb1 |
gamma-aminobutyric acid type A receptor subunit beta1 |
multiple interactions |
ISO |
Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form] |
CTD |
PMID:29038840 |
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NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
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G |
Gabrb2 |
gamma-aminobutyric acid type A receptor subunit beta 2 |
multiple interactions |
ISO |
Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form] |
CTD |
PMID:29038840 |
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NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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G |
Gabrb3 |
gamma-aminobutyric acid type A receptor subunit beta 3 |
multiple interactions |
ISO |
Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]; Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] |
CTD |
PMID:29038840 |
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NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
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G |
Gabrd |
gamma-aminobutyric acid type A receptor subunit delta |
decreases expression multiple interactions |
EXP ISO |
Pregnanolone results in decreased expression of GABRD protein Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein] |
CTD |
PMID:16914187 PMID:29038840 |
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NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
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G |
Gabre |
gamma-aminobutyric acid type A receptor subunit epsilon |
decreases response to substance |
EXP |
GABRE protein results in decreased susceptibility to Pregnanolone |
CTD |
PMID:9039914 |
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NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693
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G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
multiple interactions |
ISO |
Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form] |
CTD |
PMID:29038840 |
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NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
EXP |
Pregnanolone results in decreased expression of GSK3B protein |
CTD |
PMID:17443805 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hsd17b10 |
hydroxysteroid (17-beta) dehydrogenase 10 |
multiple interactions |
ISO |
[Pregnanolone co-treated with NAD] binds to HSD17B10 protein |
CTD |
PMID:25526675 |
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NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
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G |
Il1b |
interleukin 1 beta |
decreases response to substance |
ISO |
Pregnanolone results in decreased susceptibility to IL1B protein |
CTD |
PMID:19458216 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Mag |
myelin-associated glycoprotein |
increases expression |
EXP |
Pregnanolone results in increased expression of MAG mRNA |
CTD |
PMID:16787508 |
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NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Pregnanolone results in decreased phosphorylation of and results in decreased activity of MAPK1 protein |
CTD |
PMID:16581232 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapt |
microtubule-associated protein tau |
increases phosphorylation decreases expression |
EXP |
Pregnanolone results in increased phosphorylation of MAPT protein Pregnanolone results in decreased expression of MAPT protein |
CTD |
PMID:17443805 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mpz |
myelin protein zero |
increases expression |
EXP |
Pregnanolone results in increased expression of MPZ mRNA |
CTD |
PMID:16787508 |
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NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions increases activity |
ISO |
Pregnanolone metabolite inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] Pregnanolone metabolite results in increased activity of NR1H4 protein |
CTD |
PMID:22961653 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
Pregnanolone analog inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Pregnanolone inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] |
CTD |
PMID:16581232 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Penk |
proenkephalin |
increases expression |
EXP |
Pregnanolone results in increased expression of PENK mRNA |
CTD |
PMID:19458216 |
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NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Pmp22 |
peripheral myelin protein 22 |
increases expression |
EXP |
Pregnanolone results in increased expression of PMP22 mRNA |
CTD |
PMID:16787508 |
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NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
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G |
Prkca |
protein kinase C, alpha |
decreases expression |
ISO |
Pregnanolone results in decreased expression of PRKCA protein |
CTD |
PMID:16581232 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Slc1a1 |
solute carrier family 1 member 1 |
multiple interactions |
EXP |
Pregnanolone results in increased localization of and results in increased activity of SLC1A1 protein |
CTD |
PMID:21688266 |
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NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
increases chemical synthesis |
ISO |
SRD5A1 protein results in increased chemical synthesis of Pregnanolone |
CTD |
PMID:25463305 |
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NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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