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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenoprofen
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Accession:CHEBI:5004 term browser browse the term
Definition:A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Synonyms:related_synonym: (+-)-m-phenoxyhydratropic acid;   2-(3-phenoxyphenyl)propanoic acid;   2-(3-phenoxyphenyl)propionic acid;   2-(m-phenoxyphenyl)propionic acid;   alpha-(m-phenoxyphenyl)propionic acid;   alpha-methyl-3-phenoxybenzeneacetic acid;   fenoprofene;   fenoprofeno;   fenoprofenum
 alt_id: CHEBI:355534
 xref: CAS:31879-05-7;   DrugBank:DB00573
 xref_mesh: MESH:D005279
 xref: Patent:US3600437;   Reaxys:2118687;   drugcentral:1154;   kegg.compound:C06997;   kegg.drug:D02350;   pubmed:21328296;   pubmed:21342694;   pubmed:25554116;   pubmed:28166217;   pubmed:30168706;   pubmed:4616811;   wikipedia.en:_Fenoprofen
 chemrof_formula: C15H14O3
 chemrof_smiles: CC(C(=O)O)c1cccc(Oc2ccccc2)c1
 chemrof_inchi: InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)
 chemrof_inchikey: RDJGLLICXDHJDY-UHFFFAOYSA-N
 cyclic_relationship: is_conjugate_acid_of CHEBI:60566


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fenoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases metabolic processing EXP ACSL1 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases metabolic processing EXP ACSL6 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,940,747...39,002,873 		JBrowse link
G Alb albumin multiple interactions
affects binding 		ISO Fenoprofen inhibits the reaction [Valproic Acid binds to ALB protein]; Ibuprofen inhibits the reaction [Fenoprofen binds to ALB protein]; Palmitic Acid inhibits the reaction [Fenoprofen binds to ALB protein] CTD PMID:62049 PMID:8946661 PMID:9353694 PMID:9470966 PMID:19596536 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Fenoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Fenoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Fenoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Fenoprofen binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fenoprofen binds to and results in increased activity of PPARG protein CTD PMID:9013583 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgr1 prostaglandin reductase 1 affects activity ISO Fenoprofen affects the activity of PTGR1 protein CTD PMID:25619643 NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Fenoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Fenoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,763,033...4,772,141 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Fenoprofen inhibits the reaction [rolafagrel results in decreased expression of TGFB1 mRNA] CTD PMID:8877289 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Fenoprofen co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation 		ISO Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Fenoprofen; UGT2B7 protein results in increased glucuronidation of Fenoprofen 		CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        anti-inflammatory agent 16713
          anti-inflammatory drug 15094
            non-steroidal anti-inflammatory drug 14401
              fenoprofen 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbon oxoacid 17678
                                    carboxylic acid 17675
                                      monocarboxylic acid 17142
                                        fenoprofen 15
paths to the root