glycosyloxyflavone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	glycosyloxyflavone	go back to main search page
Accession:	CHEBI:50018	browse the term
Definition:	A member of the class of flavones having one or more glycosyl residues attached at unspecified positions.
Synonyms:	related_synonym:	flavone glycoside; flavone glycosides; glycosyloxyflavones

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Rat (611) Mouse (643) Human (622) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (611)

afzelin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

melanocyte inducing transcription factor

increases expression

afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

tyrosinase

multiple interactions
increases expression

afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

increases expression

afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

apigenin 7-O-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glycophorin A

increases expression

apigetrin results in increased expression of GYPA protein

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

baicalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
increases expression

baicalin results in increased expression of and results in increased activity of ACHE protein
baicalin results in increased expression of ACHE mRNA

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aryl hydrocarbon receptor

increases activity

baicalin results in increased activity of AHR protein

PMID:17869316 PMID:26204831

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

allograft inflammatory factor 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

albumin

multiple interactions

baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 5-lipoxygenase

multiple interactions

baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

angiopoietin 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of ANGPT1 mRNA]

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

activating transcription factor 2

multiple interactions

baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

baicalin results in increased expression of BAX protein
baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein]
baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]

PMID:21457722 PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein]
baicalin results in decreased expression of BCL2 protein
baicalin affects the reaction [Rotenone results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]

PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein]
baicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]

PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

baicalin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]

PMID:34333357 PMID:35088608

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

baicalin results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

increases expression
decreases expression
multiple interactions

baicalin results in increased expression of CCND1 mRNA
baicalin results in decreased expression of CCND1 protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]

PMID:19160421 PMID:21457722

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

collagen type I alpha 2 chain

multiple interactions

baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein

PMID:18451504 PMID:26204831

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]
baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

epidermal growth factor

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ETS transcription factor ELK1

multiple interactions

baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

forkhead box A2

decreases expression

baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

glutamic-oxaloacetic transaminase 1

multiple interactions

baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
baicalin inhibits the reaction [Arsenic Trioxide results in increased activity of GPT protein]

PMID:15645217 PMID:35088608

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hes family bHLH transcription factor 1

increases expression
multiple interactions

baicalin results in increased expression of HES1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression
multiple interactions

baicalin results in increased expression of HEY1 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

heme oxygenase 1

multiple interactions
increases expression

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HMOX1 protein]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]
baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein

PMID:16824337 PMID:18187930 PMID:38016618

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

multiple interactions
decreases expression

baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]
baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

hepatocyte nuclear factor 4, alpha

decreases expression
multiple interactions

baicalin results in decreased expression of HNF4A protein
baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]
baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heat shock protein family B (small) member 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein]

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interleukin 1 beta

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]
baicalin inhibits the reaction [Rotenone results in increased expression of IL1B protein]

PMID:29031535 PMID:35088608 PMID:36446982 PMID:38016618

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression
multiple interactions

baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]

PMID:22019745 PMID:29031535 PMID:34333357 PMID:35088608 PMID:38016618

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

integrin subunit alpha 4

multiple interactions

baicalin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; baicalin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

Janus kinase 2

multiple interactions

baicalin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

kinase insert domain receptor

multiple interactions

baicalin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

mitogen activated protein kinase 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MYD88, innate immune signal transduction adaptor

decreases expression

baicalin results in decreased expression of MYD88 protein

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases expression

baicalin results in increased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]

PMID:29031535 PMID:38016618

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
decreases expression

baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein
baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]

PMID:18187930 PMID:22019745 PMID:24312512

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

increases activity
increases expression

baicalin results in increased activity of NOTCH1 protein
baicalin results in increased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Baicalin increases expression of NR1H3 mRNA and protein in foam cells

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

pyruvate kinase M1/2

increases activity

baicalin results in increased activity of PKM protein

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

peroxisome proliferator-activated receptor gamma

multiple interactions

baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

proline rich membrane anchor 1

increases expression

baicalin results in increased expression of PRIMA1 mRNA

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

prostaglandin-endoperoxide synthase 2

decreases expression

baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

baicalin affects the localization of and results in decreased expression of RELA protein
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RELA protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

PMID:22019745 PMID:34333357 PMID:38016618

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

synuclein alpha

multiple interactions

[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

signal transducer and activator of transcription 3

multiple interactions

baicalin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TEK receptor tyrosine kinase

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of TEK mRNA]

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transcription factor A, mitochondrial

decreases expression
multiple interactions

baicalin results in decreased expression of TFAM mRNA
baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transforming growth factor, beta 1

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of TGFB1 mRNA]; baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

PMID:19474275 PMID:34414639

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

toll-like receptor 4

decreases expression
multiple interactions

baicalin results in decreased expression of TLR4 protein
baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TLR4 protein]
baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

PMID:22019745 PMID:24312512 PMID:34333357

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein
baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]

PMID:16824337 PMID:18187930 PMID:22019745 PMID:34333357 PMID:35088608 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

baicalin results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thioredoxin interacting protein

multiple interactions

baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

ubiquitin specific peptidase 27, X-linked

multiple interactions

baicalin inhibits the reaction [Streptozocin results in increased expression of USP27X protein]

NCBI chr X:15,123,620...15,126,855
Ensembl chr X:15,124,596...15,125,912

G

vascular endothelial growth factor A

multiple interactions

baicalin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

multiple interactions

baicalin inhibits the reaction [Streptozocin results in decreased expression of VEGFC mRNA]

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

xanthine dehydrogenase

multiple interactions

baicalin inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

diosmin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

Diosmin binds to and results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

BCL2-associated agonist of cell death

multiple interactions

Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]

PMID:21477647 PMID:32061149

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]

PMID:21477647 PMID:23665045 PMID:29187079 PMID:32061149

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]

PMID:22056647 PMID:23665045

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CEA cell adhesion molecule 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of CEACAM1 protein]

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

cAMP responsive element binding protein 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

enolase 2

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein]

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

glutathione peroxidase 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of and results in decreased activity of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]

PMID:23665045 PMID:32061149

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

interleukin 6

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

marker of proliferation Ki-67

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

myeloperoxidase

multiple interactions

Diosmin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prostaglandin E receptor 2

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGER2 protein]

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]

PMID:23665045 PMID:29187079 PMID:32061149 PMID:35920545

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor necrosis factor

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:21477647 PMID:23665045 PMID:29187079

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

xanthine dehydrogenase

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]

PMID:23665045 PMID:32061149

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

gossypin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 1

multiple interactions
decreases phosphorylation

gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]
gossypin results in decreased phosphorylation of ATF1 protein

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

aurora kinase A

multiple interactions

gossypin binds to and results in decreased activity of AURKA protein

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

Bcl2-like 1

decreases expression

gossypin results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 3

increases cleavage

gossypin results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases cleavage

gossypin results in increased cleavage of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases cleavage

gossypin results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; gossypin inhibits the reaction [Oleic Acid results in increased activity of CAT protein]

PMID:37148149 PMID:37696682

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

gossypin results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

gossypin results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin-dependent kinase 1

decreases phosphorylation

gossypin results in decreased phosphorylation of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

C-reactive protein

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

epidermal growth factor

multiple interactions

gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

heme oxygenase 1

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 10

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17A

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A protein]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL1B mRNA]

PMID:37148149 PMID:37696682

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL5 protein]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]

PMID:37148149 PMID:37696682

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation

gossypin results in decreased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

myeloperoxidase

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

poly (ADP-ribose) polymerase 1

increases cleavage

gossypin results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prostaglandin-endoperoxide synthase 2

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

ribosomal protein S6 kinase A3

multiple interactions

gossypin binds to and results in decreased activity of RPS6KA3 protein

NCBI chr X:35,517,306...35,623,296
Ensembl chr X:35,517,306...35,623,207

G

transforming growth factor, beta 1

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF protein]

PMID:37148149 PMID:37696682

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

icariin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

increases expression

icariin results in increased expression of ADRB1 mRNA

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein
icariin results in increased phosphorylation of AKT1 protein
afimoxifene inhibits the reaction [icariin results in increased phosphorylation of AKT1 protein]; icariin affects the reaction [Diethylhexyl Phthalate affects the phosphorylation of AKT1 protein]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of AKT1 protein]; icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]

PMID:32344236 PMID:35259346

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein

multiple interactions

icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]; icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

asparaginase

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of ASPG protein]

NCBI chr 6:131,176,727...131,196,268
Ensembl chr 6:131,176,874...131,196,268

G

beta-secretase 1

multiple interactions

icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA]

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2, apoptosis regulator

affects expression
multiple interactions

icariin affects the expression of BCL2 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

affects expression
multiple interactions

icariin affects the expression of BCL2L11 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased expression of BCL2L11 protein]

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]

PMID:18236786 PMID:18295595

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 2

multiple interactions
increases expression

NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]

PMID:15724410 PMID:16543677 PMID:17355822 PMID:19747809 PMID:20019778

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

increases expression

icariin results in increased expression of BMP4 mRNA

PMID:18295595 PMID:20019778

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

complement C3

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of C3 protein]

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

CART prepropeptide

increases expression

icariin results in increased expression of CARTPT mRNA; icariin results in increased expression of CARTPT protein

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

G

caspase 1

increases cleavage

icariin results in increased cleavage of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

cAMP responsive element binding protein 1

multiple interactions
increases phosphorylation

[naphthol AS-E phosphate co-treated with icariin] results in increased phosphorylation of CREB1 protein; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of CREB1 protein]; icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of CREB1 protein]
icariin results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression
multiple interactions

icariin results in increased expression of CYP11A1 mRNA; icariin results in increased expression of CYP11A1 protein
[icariin co-treated with Diethylhexyl Phthalate] results in increased expression of CYP11A1 mRNA; [icariin co-treated with naphthol AS-E phosphate] results in decreased expression of CYP11A1 protein; [MK 2206 co-treated with icariin] results in increased expression of CYP11A1 mRNA; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]; icariin inhibits the reaction [MK 2206 results in decreased expression of CYP11A1 protein]

PMID:31175881 PMID:35259346

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DnaJ heat shock protein family (Hsp40) member C12

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of DNAJC12 protein]

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

epidermal growth factor receptor

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

fibrinogen alpha chain

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of FGA protein]

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of FGB protein]

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibrinogen gamma chain

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of FGG protein]

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

icariin results in increased expression of FOS mRNA; icariin results in increased expression of FOS protein
SB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]; U 0126 inhibits the reaction [icariin results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O3

multiple interactions
affects localization

icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]
icariin affects the localization of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

GATA binding protein 4

increases expression

icariin results in increased expression of GATA4 mRNA

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

glutamic--pyruvic transaminase

multiple interactions

icariin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hepatitis A virus cellular receptor 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of HAVCR1 mRNA]; icariin inhibits the reaction [Folic Acid results in increased expression of HAVCR1 protein]

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

haptoglobin

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of HP protein]

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

increases expression
multiple interactions

icariin results in increased expression of HSD3B1 mRNA; icariin results in increased expression of HSD3B1 protein
icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

inhibitor of DNA binding 1

increases expression

icariin results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

insulin-like growth factor 1

increases expression

icariin results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 1 beta

multiple interactions
increases expression

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; icariin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]
icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL1B protein]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL1B protein]]
icariin results in increased expression of IL1B protein

PMID:32344236 PMID:35532261 PMID:37888945

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

affects expression
multiple interactions

icariin affects the expression of IL6 protein
icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL6 protein]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL6 protein]]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; icariin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]

PMID:25472572 PMID:32344236 PMID:37888945

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inter-alpha-trypsin inhibitor heavy chain 4

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of ITIH4 protein]

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

icariin results in increased expression of JUN mRNA; icariin results in increased expression of JUN protein
SB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; U 0126 inhibits the reaction [icariin results in increased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

Klotho

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of KL mRNA]

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

kelch-like family member 11

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of KLHL11 protein]

NCBI chr10:85,398,487...85,409,049
Ensembl chr10:85,398,487...85,409,049

G

lipocalin 2

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of LCN2 mRNA]

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK1 protein]
icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of MAPK1 protein]

PMID:18423597 PMID:37888945

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK3 protein]
icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of MAPK3 protein]

PMID:18423597 PMID:37888945

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myocyte enhancer factor 2C

affects localization
multiple interactions
increases expression

icariin affects the localization of MEF2C protein
SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]; SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]; U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]; U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

microRNA 1224

decreases expression

icariin results in decreased expression of MIR1224 mRNA

NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986

G

microRNA 139

decreases expression

icariin results in decreased expression of MIR139 mRNA

NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902

G

microRNA 140

decreases expression

icariin results in decreased expression of MIR140 mRNA

NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675

G

microRNA 146b

increases expression

icariin results in increased expression of MIR146B mRNA

NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525

G

microRNA 150

decreases expression

icariin results in decreased expression of MIR150 mRNA

NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108

G

microRNA 183

increases expression

icariin results in increased expression of MIR183 mRNA

NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723

G

microRNA 200a

increases expression

icariin results in increased expression of MIR200A mRNA

NCBI chr 5:166,648,494...166,648,582

G

microRNA 200b

increases expression

icariin results in increased expression of MIR200B mRNA

NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366

G

microRNA 205

increases expression

icariin results in increased expression of MIR205 mRNA

NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985

G

microRNA 206

multiple interactions

icariin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of MIR206 mRNA]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL1B protein]]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL6 protein]]
icariin inhibits the reaction [Dietary Fats results in decreased expression of MIR206 mRNA]

NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332

G

microRNA 21

increases expression

icariin results in increased expression of MIR21A mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 223

decreases expression

icariin results in decreased expression of MIR223 mRNA

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

G

microRNA 30e

increases expression

icariin results in increased expression of MIR30E mRNA

NCBI chr 5:134,352,232...134,352,323
Ensembl chr 5:134,352,232...134,352,323

G

microRNA 3545

increases expression

icariin results in increased expression of MIR203 mRNA

NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656

G

microRNA 429

increases expression

icariin results in increased expression of MIR429 mRNA

NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543

G

microRNA 455

decreases expression

icariin results in decreased expression of MIR455 mRNA

NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390

G

matrix metallopeptidase 9

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

metallothionein 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of MT1 protein]

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of MT2 protein]

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

mucin 5B, oligomeric mucus/gel-forming

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA

NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250

G

myosin heavy chain 6

increases expression

icariin results in increased expression of MYH6 mRNA

PMID:15780198 PMID:16490167

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin light chain 2

increases expression

icariin results in increased expression of MYL2 mRNA

PMID:15780198 PMID:16490167

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

G

NFE2 like bZIP transcription factor 1

increases expression

icariin results in increased expression of NFE2L1 mRNA; icariin results in increased expression of NFE2L1 protein

NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318

G

NFKB inhibitor alpha

multiple interactions

icariin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein; SB 203580 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; U 0126 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

PMID:18423597 PMID:20686223

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NK2 homeobox 5

increases expression

icariin results in increased expression of NKX2-5 mRNA

NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934

G

NLR family, pyrin domain containing 3

increases expression

icariin results in increased expression of NLRP3 mRNA; icariin results in increased expression of NLRP3 protein

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

noggin

multiple interactions

NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]

PMID:18295595 PMID:19747809

NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339

G

nitric oxide synthase 1

increases expression

icariin results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases expression
multiple interactions

icariin results in increased expression of NOS2 mRNA; icariin results in increased expression of NOS2 protein
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:15329286 PMID:16281085 PMID:20686223

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression
multiple interactions

icariin results in increased expression of NOS3 mRNA
icariin results in increased expression of NOS3 mRNA; icariin results in increased expression of NOS3 protein
icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; icariin results in increased expression of and results in increased activity of NOS3 protein

PMID:15329286 PMID:17499557

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide receptor 3

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of NPR3 protein]

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

nuclear receptor subfamily 5, group A, member 1

multiple interactions
increases expression

icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 protein]
icariin results in increased expression of NR5A1 mRNA; icariin results in increased expression of NR5A1 protein

PMID:31175881 PMID:35259346

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

orosomucoid 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of ORM1 protein]

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

phenylalanine hydroxylase

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of PAH protein]

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of PCK1 protein]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

phosphodiesterase 5A

decreases activity
decreases expression

icariin analog results in decreased activity of PDE5A protein; icariin results in decreased activity of PDE5A protein
icariin results in decreased expression of PDE5A mRNA alternative form

PMID:17120748 PMID:18778098

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

platelet factor 4

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of PF4 protein]

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

progesterone receptor

increases expression
multiple interactions

icariin results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [icariin results in increased expression of PGR mRNA]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

peroxisome proliferator activated receptor alpha

increases expression

icariin results in increased expression of PPARA mRNA; icariin results in increased expression of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

icariin results in increased expression of PPARGC1A mRNA; icariin results in increased expression of PPARGC1A protein
Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]

PMID:17883938 PMID:31251943

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

increases activity
multiple interactions

icariin results in increased activity of RELA protein
icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of RELA protein]
icariin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; icariin results in increased expression of and affects the localization of RELA protein; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; U 0126 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]

PMID:17499557 PMID:18423597 PMID:20686223 PMID:37888945

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RUNX family transcription factor 2

increases expression
multiple interactions

icariin results in increased expression of RUNX2 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]

PMID:18295595 PMID:19747809 PMID:20019778

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

serpin family A member 3N

multiple interactions

icariin inhibits the reaction [Folic Acid results in increased expression of SERPINA3N protein]

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

sirtuin 1

multiple interactions
affects expression
increases expression

icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]
icariin affects the expression of SIRT1 mRNA; icariin affects the expression of SIRT1 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]
icariin results in increased expression of SIRT1 mRNA; icariin results in increased expression of SIRT1 protein

PMID:19303870 PMID:25472572

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 3

multiple interactions

Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 13 member 2

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC13A2 protein]

NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127

G

solute carrier family 17 member 7

multiple interactions

icariin inhibits the reaction [bisphenol A results in decreased expression of SLC17A7 protein]

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 22 member 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC22A1 protein]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 6

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC22A6 protein]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC22A8 protein]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 2 member 2

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC2A2 protein]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 34 member 1

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC34A1 protein]

NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852

G

solute carrier family 34 member 3

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC34A3 protein]

NCBI chr 3:8,044,294...8,050,034
Ensembl chr 3:8,044,296...8,049,970

G

solute carrier family 6 member 13

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of SLC6A13 protein]

NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152

G

solute carrier organic anion transporter family member 1B2

decreases activity
multiple interactions

icariin results in decreased activity of SLCO1B3 protein
[icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2b1

multiple interactions
decreases activity

[icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

SMAD family member 4

increases expression
multiple interactions

icariin results in increased expression of SMAD4 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

SMAD family member 6

multiple interactions

SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]

NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763

G

superoxide dismutase 2

multiple interactions
affects expression

icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein]
icariin affects the expression of SOD2 protein

PMID:19782061 PMID:25472572

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

icariin inhibits the reaction [Folic Acid results in increased expression of SPP1 protein]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]

PMID:16696327 PMID:18236786 PMID:18295595 PMID:38272249

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases phosphorylation
multiple interactions

icariin results in increased phosphorylation of SRC protein
afimoxifene inhibits the reaction [icariin results in increased phosphorylation of SRC protein]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

trefoil factor 1

multiple interactions
increases expression

fulvestrant inhibits the reaction [icariin results in increased expression of TFF1 mRNA]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

increases expression

icariin results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

icariin inhibits the reaction [Rotenone results in decreased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions
affects expression

icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein
icariin affects the expression of TNF protein

PMID:20686223 PMID:25472572 PMID:32344236

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

increases expression
multiple interactions

icariin results in increased expression of TNFRSF11B mRNA
NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

decreases expression
multiple interactions

icariin results in decreased expression of TNFSF11 mRNA
NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

increases expression

icariin results in increased expression of TRP53 mRNA; icariin results in increased expression of TRP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tetratricopeptide repeat domain 36

multiple interactions

icariin inhibits the reaction [Folic Acid results in decreased expression of TTC36 protein]

NCBI chr 8:45,112,737...45,116,345

icariside II

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

baohuoside I results in decreased expression of ABCB11 mRNA; baohuoside I results in decreased expression of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

decreases expression

baohuoside I results in decreased expression of ABCC2 mRNA; baohuoside I results in decreased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

baohuoside I results in decreased phosphorylation of AKT1 protein
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT1 substrate 1

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]
baohuoside I results in decreased phosphorylation of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

alkaline phosphatase, biomineralization associated

increases expression
increases secretion

baohuoside I results in increased expression of ALPL mRNA
baohuoside I results in increased secretion of ALPL protein

PMID:17764702 PMID:35802278

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

baohuoside I results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

baohuoside I results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

increases expression

baohuoside I results in increased expression of BGLAP mRNA

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

B-Raf proto-oncogene, serine/threonine kinase

decreases phosphorylation
multiple interactions

baohuoside I results in decreased phosphorylation of BRAF protein
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

caspase 3

increases cleavage
increases activity

baohuoside I results in increased cleavage of CASP3 protein
baohuoside I results in increased activity of CASP3 protein

PMID:19289254 PMID:22687635

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

baohuoside I results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
increases cleavage

baohuoside I results in increased activity of CASP9 protein
baohuoside I results in increased cleavage of CASP9 protein

PMID:19289254 PMID:22687635

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cadherin 1

multiple interactions
increases expression

SMO protein inhibits the reaction [baohuoside I results in increased expression of CDH1 mRNA]
baohuoside I results in increased expression of CDH1 mRNA; baohuoside I results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression
multiple interactions

baohuoside I results in decreased expression of CDH2 mRNA; baohuoside I results in decreased expression of CDH2 protein
SMO protein inhibits the reaction [baohuoside I results in decreased expression of CDH2 mRNA]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

collagen type I alpha 2 chain

increases expression

baohuoside I results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

cytochrome P450 family 7 subfamily A member 1

increases expression

baohuoside I results in increased expression of CYP7A1 mRNA; baohuoside I results in increased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

epidermal growth factor

multiple interactions

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
baohuoside I results in decreased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

estrogen receptor 1

multiple interactions

baohuoside I binds to and results in increased degradation of ESR1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [baohuoside I results in increased degradation of ESR1 protein]; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glutamic-oxaloacetic transaminase 1

increases secretion

baohuoside I results in increased secretion of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases secretion

baohuoside I results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glycogen synthase kinase 3 beta

decreases phosphorylation

baohuoside I results in decreased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
baohuoside I results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
baohuoside I results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 370

increases expression

baohuoside I results in increased expression of MIR370 mRNA

NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335

G

marker of proliferation Ki-67

decreases expression

baohuoside I results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]
baohuoside I results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

nitric oxide synthase 2

decreases expression

baohuoside I results in decreased expression of NOS2

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
decreases expression

baohuoside I results in decreased expression of and results in decreased activity of and affects the localization of NR0B2 protein; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein]
baohuoside I results in decreased expression of NR0B2 mRNA
baohuoside I results in decreased expression of NR0B2 mRNA; baohuoside I results in decreased expression of NR0B2 protein

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

baohuoside I results in decreased expression of NR1H4 mRNA; baohuoside I results in decreased expression of NR1H4 protein

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

baohuoside I results in increased cleavage of PARP1 protein
Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein]; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]

PMID:19289254 PMID:22687635

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

3-phosphoinositide dependent protein kinase-1

decreases phosphorylation

baohuoside I results in decreased phosphorylation of PDPK1 protein

NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

baohuoside I results in decreased expression of PTGS2
[baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 10 member 1

increases expression

baohuoside I results in increased expression of SLC10A1 protein
baohuoside I results in increased expression of SLC10A1 mRNA; baohuoside I results in increased expression of SLC10A1 protein

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier organic anion transporter family, member 1a4

decreases expression

baohuoside I results in decreased expression of SLCO1A1 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

smoothened, frizzled class receptor

decreases expression
multiple interactions

baohuoside I results in decreased expression of SMO mRNA
SMO protein inhibits the reaction [baohuoside I results in decreased expression of CDH2 mRNA]; SMO protein inhibits the reaction [baohuoside I results in decreased expression of VIM mRNA]; SMO protein inhibits the reaction [baohuoside I results in increased expression of CDH1 mRNA]

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

TNF receptor superfamily member 11B

increases expression

baohuoside I results in increased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

decreases expression

baohuoside I results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

vascular endothelial growth factor A

decreases expression

baohuoside I results in decreased expression of VEGFA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression
multiple interactions

baohuoside I results in decreased expression of VIM mRNA; baohuoside I results in decreased expression of VIM protein
SMO protein inhibits the reaction [baohuoside I results in decreased expression of VIM mRNA]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

kaempferol 3-O-beta-D-galactoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phospholipase A2 group IIA

affects activity

kaempferol-3-O-galactoside affects the activity of PLA2G2A protein

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

kaempferol 3-O-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

catalase

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

hes family bHLH transcription factor 1

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

interleukin 10

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:22210036 PMID:35537655

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

PMID:22210036 PMID:35537655

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

NFKB inhibitor alpha

multiple interactions

astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein]

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

prostaglandin-endoperoxide synthase 2

multiple interactions

astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

recombination signal binding protein for immunoglobulin kappa J region

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein]

NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]

PMID:22210036 PMID:35537655

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor necrosis factor

multiple interactions

astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:22210036 PMID:35537655

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

luteolin 7-O-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

[luteolin-7-glucoside co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein
luteolin-7-glucoside results in decreased phosphorylation of AKT1 protein

PMID:31157476 PMID:34165247

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

increases expression

luteolin-7-glucoside results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]; luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]
luteolin-7-glucoside results in decreased expression of BCL2 protein

PMID:31157476 PMID:31381935 PMID:34165247

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

luteolin-7-glucoside results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

increases expression

luteolin-7-glucoside results in increased expression of BID protein alternative form

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

multiple interactions
increases cleavage

benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [luteolin-7-glucoside results in increased cleavage of CASP3 protein]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]

PMID:31157476 PMID:31381935 PMID:34165247

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

luteolin-7-glucoside results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage

luteolin-7-glucoside results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

luteolin-7-glucoside results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

luteolin-7-glucoside results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin-dependent kinase 1

decreases phosphorylation

luteolin-7-glucoside results in decreased phosphorylation of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression

luteolin-7-glucoside results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

luteolin-7-glucoside results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

estrogen receptor 1

multiple interactions
increases activity

1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR1 protein]]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR1 protein]]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR1 protein]
luteolin-7-glucoside results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases activity

4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR2 protein]]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR2 protein]]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of ESR2 protein]
luteolin-7-glucoside results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fas cell surface death receptor

increases expression

luteolin-7-glucoside results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FOS protein]]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FOS protein]]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FOS protein]]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

interleukin 6

multiple interactions

luteolin-7-glucoside inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions

luteolin-7-glucoside results in decreased phosphorylation of MAPK1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]

PMID:31381935 PMID:34165247

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]
luteolin-7-glucoside results in decreased phosphorylation of MAPK3 protein

PMID:31381935 PMID:34165247

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

luteolin-7-glucoside results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]; SB 203580 promotes the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

receptor interacting serine/threonine kinase 1

increases expression

luteolin-7-glucoside results in increased expression of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

signal transducer and activator of transcription 3

multiple interactions

1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of STAT3 protein]]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of STAT3 protein]]; Fulvestrant inhibits the reaction [luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of STAT3 protein]]; luteolin-7-glucoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor necrosis factor

multiple interactions

luteolin-7-glucoside inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

luteolin-7-glucoside results in increased expression of TNFRSF1A protein

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

miquelianin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase medium chain

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

adrenoceptor beta 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

angiotensinogen

multiple interactions

quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

arachidonate 5-lipoxygenase

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

amyloid beta precursor protein

multiple interactions
decreases expression

quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form]
quercetin 3-O-glucuronide results in decreased expression of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

catalase

multiple interactions

[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CD36 molecule

decreases expression

quercetin 3-O-glucuronide results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

carnitine palmitoyltransferase 1A

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

Fas cell surface death receptor

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

heme oxygenase 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein

PMID:24929186 PMID:25716194

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor substrate 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

matrix metallopeptidase 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

macrophage scavenger receptor 1

decreases expression

quercetin 3-O-glucuronide results in decreased expression of MSR1 mRNA

NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676

G

nitric oxide synthase 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

peroxisome proliferator activated receptor alpha

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

quercetin 3-O-glucuronide results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 8

multiple interactions
increases uptake

quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]
SLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

sterol regulatory element binding transcription factor 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

tumor necrosis factor

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of TNF protein]
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein]

PMID:17880982 PMID:23504962 PMID:26190035

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

decreases activity

quercetin 3-O-glucuronide results in decreased activity of TNFSF11 protein

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

vascular cell adhesion molecule 1

multiple interactions

quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

myricitrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

alkaline phosphatase, biomineralization associated

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

apolipoprotein E

multiple interactions

myricitrin inhibits the reaction [APOE gene mutant form results in decreased activity of CAT protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased activity of CASP3 protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CCL2 protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CRP protein]; myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of ICAM1 protein]

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

BCL2 associated X, apoptosis regulator

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

caspase 3

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
myricitrin inhibits the reaction [APOE gene mutant form results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]
myricitrin inhibits the reaction [APOE gene mutant form results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

collagen type I alpha 1 chain

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

C-reactive protein

multiple interactions

myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of CRP protein]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

myricitrin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

glutamic--pyruvic transaminase

multiple interactions

myricitrin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

intercellular adhesion molecule 1

multiple interactions

myricitrin inhibits the reaction [APOE gene mutant form results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 6

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

nitric oxide synthase 3

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased activity of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

proliferating cell nuclear antigen

multiple interactions

myricitrin promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

peroxisome proliferator-activated receptor gamma

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

transforming growth factor, beta 1

multiple interactions

myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

myricitrin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

multiple interactions

myricitrin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

quercetin 3-O-beta-D-galactopyranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases expression
multiple interactions

hyperoside results in increased expression of ACHE mRNA
hyperoside results in increased expression of and results in increased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

BCL2 associated X, apoptosis regulator

multiple interactions

hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of BAX protein]
hyperoside inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]

PMID:18552516 PMID:31326407

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 5

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of BIRC5 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions

[Quercetin co-treated with hyperoside] results in increased cleavage of CASP3 protein

PMID:24173369 PMID:25354548

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

cyclopamine inhibits the reaction [hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]; hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome c, somatic

multiple interactions

hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions

hyperoside results in decreased activity of CYP2E1 protein
hyperoside inhibits the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

estrogen receptor 1

multiple interactions

hyperoside inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

GLI family zinc finger 1

multiple interactions
increases expression

hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of GLI1 protein]
hyperoside results in increased expression of GLI1 mRNA; hyperoside results in increased expression of GLI1 protein

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glutamic--pyruvic transaminase

multiple interactions

hyperoside inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

mitogen activated protein kinase 1

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 21

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of MIR21 mRNA; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]; MIR21 mRNA results in decreased susceptibility to [Quercetin co-treated with hyperoside]

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 27a

multiple interactions

[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in decreased expression of ZBTB10 mRNA]; [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]; [Quercetin co-treated with hyperoside] results in decreased expression of MIR27A mRNA; MIR27A mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA]

NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917

G

NFE2 like bZIP transcription factor 2

affects localization

hyperoside affects the localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NAD(P)H quinone dehydrogenase 1

increases expression

Hyperoside increases expression of Nqo1 protein in liver

RGD

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Quercetin co-treated with hyperoside] results in increased cleavage of PARP1 protein

PMID:24173369 PMID:25354548

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 4

multiple interactions

[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA; [Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 mRNA]; MIR21 mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of PDCD4 protein]

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

proline rich membrane anchor 1

increases expression

hyperoside results in increased expression of PRIMA1 mRNA

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sonic hedgehog signaling molecule

increases expression
multiple interactions

hyperoside results in increased expression of SHH mRNA; hyperoside results in increased expression of SHH protein
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SHH mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SHH protein]

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

sirtuin 1

multiple interactions

hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 2 member 2

increases expression

hyperoside analog results in increased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 5 member 1

increases expression

hyperoside analog results in increased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

smoothened, frizzled class receptor

increases expression
multiple interactions

hyperoside results in increased expression of SMO mRNA; hyperoside results in increased expression of SMO protein
hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA]; hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein]

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

Sp1 transcription factor

multiple interactions

[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA]; [Quercetin co-treated with hyperoside] results in decreased expression of SP1 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP1 protein

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

Sp3 transcription factor

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of SP3 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP3 protein

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

Sp4 transcription factor

multiple interactions

[Quercetin co-treated with hyperoside] results in decreased expression of SP4 mRNA; [Quercetin co-treated with hyperoside] results in decreased expression of SP4 protein

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

G

sulfotransferase family 2A member 1

multiple interactions
increases expression

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of SULT2A1 mRNA]
hyperoside results in increased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

tumor necrosis factor

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; hyperoside inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
increases expression

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A1 mRNA]
hyperoside results in increased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT1A6 mRNA]

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions
increases expression

hyperoside inhibits the reaction [Acetaminophen results in decreased expression of UGT2B1 mRNA]
hyperoside results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

vascular cell adhesion molecule 1

multiple interactions

hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; hyperoside inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

zinc finger and BTB domain containing 10

multiple interactions

[Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in decreased expression of ZBTB10 mRNA]; [Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA; MIR27A mRNA inhibits the reaction [[Quercetin co-treated with hyperoside] results in increased expression of ZBTB10 mRNA]

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

quercetin 3-O-beta-D-glucofuranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

aldo-keto reductase family 7 member A3

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

apolipoprotein A1

increases secretion

isoquercitrin results in increased secretion of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

activating transcription factor 6

increases expression

isoquercitrin results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ataxin 2

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 3

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2, apoptosis regulator

decreases expression

isoquercitrin results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

affects expression

isoquercitrin affects the expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases expression

isoquercitrin results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of CAT mRNA; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:30298849 PMID:30817903

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

catenin beta 1

affects expression

isoquercitrin affects the expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA
isoquercitrin results in decreased activity of CYP1A1 protein

PMID:16271822 PMID:20033131

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

isoquercitrin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 51

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of CYP51A1 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

7-dehydrocholesterol reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

epidermal growth factor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

farnesyl diphosphate farnesyl transferase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutathione peroxidase 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of GRIA3 mRNA]

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutathione S-transferase alpha 5

multiple interactions

[isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

multiple interactions

isoquercitrin inhibits the reaction [beta-Naphthoflavone results in increased expression of HMOX1 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]

PMID:21295105 PMID:30817903

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

integrin-binding sialoprotein

increases expression

isoquercitrin results in increased expression of IBSP mRNA

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interleukin 1 alpha

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in increased expression of IL1A mRNA; [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA

PMID:21295105 PMID:31068541

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

Janus kinase 1

increases expression

isoquercitrin results in increased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

increases expression

isoquercitrin results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lactase

multiple interactions

[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

low density lipoprotein receptor

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

affects expression

isoquercitrin affects the expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

malic enzyme 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

matrix metallopeptidase 2

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

NFE2 like bZIP transcription factor 2

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]

PMID:20033131 PMID:31068541

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neuronal vesicle trafficking associated 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

orthodenticle homeobox 2

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

Parkinsonism associated deglycase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

affects expression

isoquercitrin affects the expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

isoquercitrin results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peptidylprolyl isomerase D

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prostaglandin-endoperoxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA]

PMID:14654164 PMID:20045035 PMID:30817903

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RELB proto-oncogene, NF-kB subunit

increases expression

isoquercitrin results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

RUNX family transcription factor 2

increases expression

isoquercitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sterol-C5-desaturase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

serpin family E member 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 5 member 1

multiple interactions

isoquercitrin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

squalene epoxidase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein; [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA; SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

increases expression

isoquercitrin results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 6

increases expression

isoquercitrin results in increased expression of STAT6 mRNA

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

STIP1 homology and U-box containing protein 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA]

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

tyrosine hydroxylase

multiple interactions

isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

increases expression

isoquercitrin results in increased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNF mRNA]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]

PMID:14654164 PMID:21295105 PMID:30817903

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRADD protein]

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

thioredoxin 1

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

tyrosine kinase 2

affects expression

isoquercitrin affects the expression of TYK2 mRNA

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

G

ubiquitin C-terminal hydrolase L1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

quercetin 3-O-beta-D-glucopyranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

aldo-keto reductase family 7 member A3

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

apolipoprotein A1

increases secretion

isoquercitrin results in increased secretion of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

activating transcription factor 6

increases expression

isoquercitrin results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ataxin 2

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 3

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2, apoptosis regulator

decreases expression

isoquercitrin results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

affects expression

isoquercitrin affects the expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases expression

isoquercitrin results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of CAT mRNA; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:30298849 PMID:30817903

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

catenin beta 1

affects expression

isoquercitrin affects the expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

isoquercitrin inhibits the reaction [Carrageenan results in increased expression of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
multiple interactions

isoquercitrin results in decreased activity of CYP1A1 protein
[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA

PMID:16271822 PMID:20033131

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

isoquercitrin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 51

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of CYP51A1 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

7-dehydrocholesterol reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

epidermal growth factor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

farnesyl diphosphate farnesyl transferase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutathione peroxidase 2

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of GRIA3 mRNA]

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutathione S-transferase alpha 5

multiple interactions

[isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA]

PMID:20033131 PMID:20045035

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

multiple interactions

isoquercitrin inhibits the reaction [beta-Naphthoflavone results in increased expression of HMOX1 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]

PMID:21295105 PMID:30817903

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

integrin-binding sialoprotein

increases expression

isoquercitrin results in increased expression of IBSP mRNA

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

interleukin 1 alpha

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in increased expression of IL1A mRNA; [isoquercitrin co-treated with Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL1A mRNA

PMID:21295105 PMID:31068541

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

Janus kinase 1

increases expression

isoquercitrin results in increased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

increases expression

isoquercitrin results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lactase

multiple interactions

[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

low density lipoprotein receptor

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

affects expression

isoquercitrin affects the expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

malic enzyme 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

matrix metallopeptidase 2

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

isoquercitrin results in decreased expression of and results in decreased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

NFE2 like bZIP transcription factor 2

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[isoquercitrin analog co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]

PMID:20033131 PMID:31068541

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neuronal vesicle trafficking associated 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

orthodenticle homeobox 2

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA]

NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416

G

Parkinsonism associated deglycase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

affects expression

isoquercitrin affects the expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

isoquercitrin results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peptidylprolyl isomerase D

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prostaglandin-endoperoxide synthase 2

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA]

PMID:14654164 PMID:20045035 PMID:30817903

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

isoquercitrin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RELB proto-oncogene, NF-kB subunit

increases expression

isoquercitrin results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

RUNX family transcription factor 2

increases expression

isoquercitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sterol-C5-desaturase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

serpin family E member 1

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 5 member 1

multiple interactions

isoquercitrin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

squalene epoxidase

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 2

multiple interactions

[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein; [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA; SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

increases expression

isoquercitrin results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 6

increases expression

isoquercitrin results in increased expression of STAT6 mRNA

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

STIP1 homology and U-box containing protein 1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA]

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

tyrosine hydroxylase

multiple interactions

isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

increases expression

isoquercitrin results in increased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNF mRNA]; isoquercitrin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]

PMID:14654164 PMID:21295105 PMID:30817903

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

multiple interactions

isoquercitrin inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TRADD protein]

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

thioredoxin 1

multiple interactions

isoquercitrin analog inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

tyrosine kinase 2

affects expression

isoquercitrin affects the expression of TYK2 mRNA

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

G

ubiquitin C-terminal hydrolase L1

multiple interactions

isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

quercetin 4'-O-beta-D-glucopyranoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

adaptor related protein complex 5 subunit mu 1

decreases expression

spiraeoside results in decreased expression of AP5M1 protein

NCBI chr15:22,355,478...22,385,222
Ensembl chr15:22,355,500...22,377,750

G

BCL2 associated X, apoptosis regulator

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
spiraeoside results in decreased expression of BCL2 protein

PMID:32602595 PMID:34116102

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BH3 interacting domain death agonist

decreases expression

spiraeoside results in decreased expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

decreases expression

spiraeoside results in decreased expression of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

decreases expression

spiraeoside results in decreased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]]; spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin dependent kinase 2

decreases expression

spiraeoside results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

crystallin zeta

increases activity

spiraeoside results in increased activity of CRYZ protein

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

heme oxygenase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

lactase

multiple interactions

[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

NFE2 like bZIP transcription factor 2

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

phospholipase C, gamma 2

decreases phosphorylation

spiraeoside results in decreased phosphorylation of PLCG2 protein

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

solute carrier family 5 member 1

multiple interactions

[Phlorhizin results in decreased activity of SLC5A1 protein] which results in decreased uptake of spiraeoside
spiraeoside inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

PMID:12663055 PMID:17495124

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

spleen associated tyrosine kinase

decreases phosphorylation

spiraeoside results in decreased phosphorylation of SYK protein

NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410

quercitrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 4

decreases expression

quercitrin results in decreased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily F member 2

increases expression

quercitrin results in increased expression of ABCF2 mRNA

NCBI chr 4:10,594,802...10,607,620
Ensembl chr 4:10,594,907...10,607,606

G

acyl-CoA binding domain containing 6

decreases expression

quercitrin results in decreased expression of ACBD6 mRNA

NCBI chr13:67,726,786...67,863,392
Ensembl chr13:67,726,786...67,862,311

G

acyl-CoA binding domain containing 7

increases expression

quercitrin results in increased expression of ACBD7 mRNA

NCBI chr17:74,903,936...74,909,977
Ensembl chr17:74,903,177...74,905,811

G

actinin, alpha 1

affects expression

quercitrin affects the expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

actinin alpha 4

affects expression

quercitrin affects the expression of ACTN4 mRNA

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

adhesion G protein-coupled receptor B1

decreases expression

quercitrin results in decreased expression of ADGRB1 mRNA

NCBI chr 7:106,404,827...106,476,902
Ensembl chr 7:106,404,958...106,476,902

G

adhesion G protein-coupled receptor F1

decreases expression

quercitrin results in decreased expression of ADGRF1 mRNA

NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704

G

adhesion G protein-coupled receptor G1

decreases expression

quercitrin results in decreased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

adhesion G protein-coupled receptor G6

decreases expression

quercitrin results in decreased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adhesion G protein-coupled receptor G7

increases expression

quercitrin results in increased expression of ADGRG7 mRNA

NCBI chr11:43,808,101...43,877,539
Ensembl chr11:43,813,801...43,876,316

G

adhesion G protein-coupled receptor V1

increases expression

quercitrin results in increased expression of ADGRV1 mRNA

NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688

G

adenosine kinase

decreases expression

quercitrin results in decreased expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adrenoceptor alpha 2C

increases expression

quercitrin results in increased expression of ADRA2C mRNA

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

AHNAK nucleoprotein 2

increases expression

quercitrin results in increased expression of AHNAK2 mRNA

NCBI chr 6:131,830,668...131,876,311
Ensembl chr 6:131,831,454...131,854,463

G

alkB homolog 7

increases expression

quercitrin results in increased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

anaphase promoting complex subunit 15

decreases expression

quercitrin results in decreased expression of ANAPC15 mRNA

NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145

G

androgen receptor

increases expression

quercitrin results in increased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

increases expression

quercitrin results in increased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

ankyrin repeat and SOCS box-containing 6

increases expression

quercitrin results in increased expression of ASB6 mRNA

NCBI chr 3:14,110,628...14,115,274
Ensembl chr 3:14,110,628...14,115,242

G

autophagy related 7

decreases expression

quercitrin results in decreased expression of ATG7 mRNA

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

BAR/IMD domain containing adaptor protein 2

affects expression

quercitrin affects the expression of BAIAP2 mRNA

NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134

G

BCL2 associated X, apoptosis regulator

multiple interactions

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bradykinin receptor B1

decreases expression

quercitrin results in decreased expression of BDKRB1 mRNA

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

similar to human chromosome 2 open reading frame 49

decreases expression

quercitrin results in decreased expression of C2ORF49 mRNA

NCBI chr 9:45,371,396...45,382,123
Ensembl chr 9:45,371,430...45,382,120

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

quercitrin results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

caspase 3

increases activity
multiple interactions

quercitrin results in increased activity of CASP3 protein
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]

PMID:23138875 PMID:25193878

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases expression

quercitrin results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine receptor 9

decreases expression

quercitrin results in decreased expression of CCR9 mRNA

NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969

G

C-C motif chemokine receptor like 2

increases expression

quercitrin results in increased expression of CCRL2 mRNA

NCBI chr 8:111,034,279...111,036,914
Ensembl chr 8:111,034,279...111,036,664

G

CD302 molecule

decreases expression

quercitrin results in decreased expression of CD302 mRNA

NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045

G

CD38 molecule

decreases expression

quercitrin results in decreased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD74 molecule

affects expression

quercitrin affects the expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

cadherin 1

decreases expression

quercitrin results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 3

decreases expression

quercitrin results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

quercitrin results in increased expression of CELSR3 mRNA

NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354

G

centrosomal protein 95

increases expression

quercitrin results in increased expression of CEP95 mRNA

NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092

G

ceramide synthase 5

increases expression

quercitrin results in increased expression of CERS5 mRNA

NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947

G

cilia and flagella associated protein 298

decreases expression

quercitrin results in decreased expression of CFAP298 mRNA

NCBI chr11:30,181,916...30,191,302
Ensembl chr11:30,181,905...30,191,346

G

chromodomain helicase DNA binding protein 2

decreases expression

quercitrin results in decreased expression of CHD2 mRNA

NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502

G

claudin 10

affects expression

quercitrin affects the expression of CLDN10 mRNA

NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526

G

claudin 23

affects expression

quercitrin affects the expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

claudin 4

affects expression

quercitrin affects the expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 8

affects expression

quercitrin affects the expression of CLDN8 mRNA

NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513

G

collagen type III alpha 1 chain

decreases expression

quercitrin results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

coenzyme Q3 methyltransferase

decreases expression

quercitrin results in decreased expression of COQ3 mRNA

NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607

G

cysteine-rich secretory protein 1

decreases expression

quercitrin results in decreased expression of CRISP1 mRNA

NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796

G

crystallin zeta like 1

decreases expression

quercitrin results in decreased expression of CRYZL1 mRNA

NCBI chr11:30,933,140...30,977,936
Ensembl chr11:30,933,144...30,977,867