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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenarimol
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Accession:CHEBI:4998 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union.
Synonyms:related_synonym: (2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol;   (RS)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol;   2,4'-dichloro-alpha(pyrimidin-5-yl)benzhydryl alcohol;   EL 222;   Rimidin;   Rubigan;   alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol;   rac-(2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol;   rac-(R)-(2-chlorophenyl)(4-chlorophenyl)(pyrimidin-5-yl)methanol;   rac-fenarimol
 xref: CAS:60168-88-9;   HMDB:HMDB0040599
 xref_mesh: MESH:C033789
 xref: Patent:US3818009;   Patent:US3869456;   Patent:US3887708;   Pesticides:fenarimol;   Reaxys:5972869;   kegg.compound:C11226;   pubmed:12146625;   pubmed:14700530;   pubmed:15866470;   pubmed:18372651;   pubmed:22955670;   pubmed:23664474;   pubmed:8637508;   wikipedia.en:Fenarimol
 chemrof_formula: C17H12Cl2N2O


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fenarimol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP fenarimol results in decreased expression of ABCA1 mRNA CTD PMID:28970091 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Acvr2b activin A receptor type 2B decreases expression EXP fenarimol results in decreased expression of SCGB2A2 mRNA CTD PMID:15590119 NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:128,016,526...128,048,171 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions 		ISO fenarimol binds to AR protein
Dihydrotestosterone inhibits the reaction [fenarimol results in increased activity of AR protein]; fenarimol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; fenarimol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; fenarimol inhibits the reaction [Metribolone results in increased activity of AR protein] 		CTD PMID:15064155 PMID:15253041 PMID:18324785 PMID:26602169 PMID:33049310 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO fenarimol results in increased expression of CYP17A1 mRNA; fenarimol results in increased expression of CYP17A1 protein CTD PMID:21722721 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
increases expression 		ISO fenarimol results in decreased activity of CYP19A1 protein
fenarimol results in increased expression of CYP19A1 mRNA; fenarimol results in increased expression of CYP19A1 protein 		CTD PMID:10806373 PMID:11884232 PMID:12127262 PMID:16996190 PMID:21722721 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP fenarimol results in increased expression of CYP26A1 mRNA CTD PMID:28970091 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO 		fenarimol results in increased expression of CYP51 mRNA CTD PMID:28970091 PMID:29337257 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP fenarimol results in increased expression of DHCR7 mRNA CTD PMID:28970091 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression EXP fenarimol results in increased expression of DHRS3 mRNA CTD PMID:28970091 NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:162,031,386...162,065,653 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP fenarimol results in increased expression of DUSP5 mRNA CTD PMID:28970091 NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
decreases expression
multiple interactions
increases activity 		ISO fenarimol binds to ESR1 protein
fenarimol results in decreased expression of ESR1 mRNA
[Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; fenarimol binds to and results in increased activity of ESR1 protein; fenarimol promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein] 		CTD PMID:10789375 PMID:15064155 PMID:15253041 PMID:15261991 PMID:16626760 More... NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
increases activity 		ISO fenarimol binds to and results in increased activity of ESR2 protein; fenarimol promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]
fenarimol results in increased expression of ESR2 mRNA
fenarimol results in increased activity of ESR2 protein 		CTD PMID:15064155 PMID:15261991 PMID:21722721 PMID:26812056 PMID:33049310 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP fenarimol results in increased expression of FDFT1 mRNA CTD PMID:28970091 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP fenarimol results in increased expression of FSHB protein CTD PMID:16324804 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Gbx2 gastrulation brain homeobox 2 increases expression EXP fenarimol results in increased expression of GBX2 mRNA CTD PMID:28970091 NCBI chr 9:97,957,304...97,959,883
Ensembl chr 9:97,957,304...97,959,883 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity EXP fenarimol results in increased activity of GGT1 protein CTD PMID:2387028 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP fenarimol results in increased expression of HMGCR mRNA CTD PMID:28970091 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP fenarimol results in increased expression of HMGCS1 mRNA CTD PMID:28970091 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO fenarimol results in increased expression of HSD3B1 mRNA CTD PMID:21722721 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression EXP fenarimol results in decreased expression of IFRD1 mRNA CTD PMID:28970091 NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP fenarimol results in decreased expression of IGF1 mRNA CTD PMID:15590119 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP fenarimol results in increased expression of LHX1 mRNA CTD PMID:28970091 NCBI chr10:69,894,288...69,901,076
Ensembl chr10:69,894,288...69,901,076 		JBrowse link
G Lrrc75a leucine rich repeat containing 75A increases expression EXP fenarimol results in increased expression of LRRC75A mRNA CTD PMID:28970091 NCBI chr10:47,798,028...47,842,577
Ensembl chr10:47,798,028...47,842,577 		JBrowse link
G Ltf lactotransferrin decreases expression EXP fenarimol results in decreased expression of LTF mRNA CTD PMID:16324804 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP fenarimol results in increased expression of MSMO1 mRNA CTD PMID:28970091 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Ngfr nerve growth factor receptor increases expression EXP fenarimol results in increased expression of NGFR mRNA CTD PMID:28970091 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Nobox NOBOX oogenesis homeobox increases expression ISO fenarimol results in increased expression of NOBOX mRNA; fenarimol results in increased expression of NOBOX protein CTD PMID:21722721 NCBI chr 4:73,128,926...73,134,431
Ensembl chr 4:73,127,925...73,134,630 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions 		ISO fenarimol results in increased activity of NR1I2 protein
fenarimol binds to and results in increased activity of NR1I2 protein 		CTD PMID:16565514 PMID:21115097 PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL increases expression EXP fenarimol results in increased expression of NSDHL mRNA CTD PMID:28970091 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP fenarimol results in decreased expression of ODC1 mRNA CTD PMID:15590119 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fenarimol binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP fenarimol results in increased expression of RARB mRNA CTD PMID:28970091 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP fenarimol results in increased expression of RASD1 mRNA CTD PMID:28970091 NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710 		JBrowse link
G Rflna refilin A increases expression EXP fenarimol results in increased expression of RFLNA mRNA CTD PMID:28970091 NCBI chr12:37,294,643...37,323,373
Ensembl chr12:37,294,643...37,303,535 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP fenarimol results in increased expression of SC5D mRNA CTD PMID:28970091 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP fenarimol results in increased expression of SCD1 mRNA CTD PMID:28970091 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Scube1 signal peptide, CUB domain and EGF like domain containing 1 increases expression EXP fenarimol results in increased expression of SCUBE1 mRNA CTD PMID:28970091 NCBI chr 7:116,639,027...116,760,986
Ensembl chr 7:116,642,231...116,760,944 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO fenarimol results in decreased activity of SRD5A2 protein CTD PMID:17218080 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression EXP fenarimol results in increased expression of SREBF2 mRNA CTD PMID:28970091 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 increases expression EXP fenarimol results in increased expression of ST3GAL3 mRNA CTD PMID:28970091 NCBI chr 5:136,755,780...136,958,081
Ensembl chr 5:136,755,678...136,955,987 		JBrowse link
G Stambpl1 STAM binding protein-like 1 increases expression EXP fenarimol results in increased expression of STAMBPL1 mRNA CTD PMID:28970091 NCBI chr 1:241,095,695...241,158,225
Ensembl chr 1:241,113,239...241,158,225 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO fenarimol binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO fenarimol binds to and results in decreased activity of THRB protein CTD PMID:33049310 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP fenarimol results in decreased expression of TRDMT1 mRNA CTD PMID:28970091 NCBI chr17:81,510,740...81,554,036
Ensembl chr17:81,521,200...81,577,639 		JBrowse link
G Zfp496 zinc finger protein 496 increases expression EXP fenarimol results in increased expression of ZFP496 mRNA CTD PMID:28970091 NCBI chr10:44,768,463...44,787,386
Ensembl chr10:44,768,468...44,787,190 		JBrowse link
G Zfp703 zinc finger protein 703 increases expression EXP fenarimol results in increased expression of ZFP703 mRNA CTD PMID:28970091 NCBI chr16:71,779,340...71,783,510
Ensembl chr16:71,779,340...71,783,510 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      chemical substance 14602
        mixture 13915
          racemate 12303
            fenarimol 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                carbocyclic compound 18739
                                  benzenoid aromatic compound 17899
                                    benzenes 17656
                                      chlorobenzenes 15281
                                        monochlorobenzenes 12256
                                          (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol 50
                                            (R)-fenarimol 50
                                              fenarimol 50
paths to the root