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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-ethylphenol
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Accession:CHEBI:49584 term browser browse the term
Definition:A member of the class of phenols carrying an ethyl substituent at position 4.
Synonyms:related_synonym: 1-Ethyl-4-hydroxybenzene;   1-Hydroxy-4-ethylbenzene;   Formula=C8H10O;   InChI=1S/C8H10O/c1-2-7-3-5-8(9)6-4-7/h3-6,9H,2H2,1H3;   InChIKey=HXDOZKJGKXYMEW-UHFFFAOYSA-N;   Paraethylphenol;   SMILES=CCc1ccc(O)cc1;   p-Ethylphenol;   para-Ethylphenol
 alt_id: CHEBI:31126;   CHEBI:49582
 xref: CAS:123-07-9;   HMDB:HMDB0029306;   KEGG:C13637;   KNApSAcK:C00029528
 xref_mesh: MESH:C042291
 xref: MetaCyc:CPD-10596;   PDBeChem:ETY;   PMID:11724248;   PMID:22908955;   PMID:23311591;   PMID:24444954;   Reaxys:1363317;   Wikipedia:4-Ethylphenol


show annotations for term's descendants           Sort by:
4-ethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 affects localization
affects binding		 ISO 4-ethylphenol affects the localization of ESR1 protein
4-ethylphenol binds to ESR1 protein		 CTD PMID:12598185 PMID:19913605 PMID:20950447 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects localization
affects binding		 ISO 4-ethylphenol affects the localization of ESR2 protein
4-ethylphenol binds to ESR2 protein		 CTD PMID:12224631 PMID:19913605 PMID:20950447 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO 4-ethylphenol results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Il4 interleukin 4 increases expression ISO 4-ethylphenol results in increased expression of IL4 mRNA; 4-ethylphenol results in increased expression of IL4 protein CTD PMID:16169028 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 4-ethylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
4-ethylphenol results in increased phosphorylation of MAPK1 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 4-ethylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
4-ethylphenol results in increased phosphorylation of MAPK3 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [4-ethylphenol co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Prl prolactin multiple interactions
increases secretion		 ISO
EXP		 4-ethylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-ethylphenol inhibits the reaction [Estradiol results in increased secretion of PRL protein]; 4-ethylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]
4-ethylphenol results in increased secretion of PRL protein		 CTD PMID:19479013 PMID:20950447 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 4-ethylphenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 4-ethylphenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 4-ethylphenol CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            xenobiotic metabolite 16162
              fungal xenobiotic metabolite 620
                4-ethylphenol 11
                  4-ethylphenyl sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic aromatic compound 19360
                                  phenols 18655
                                    4-ethylphenol 11
                                      4-ethylphenyl sulfate 0
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