Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:c-di-GMP
go back to main search page
Accession:CHEBI:49537 term browser browse the term
Definition:A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of MP.
Synonyms:exact_synonym: 9,9'-[(2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
 related_synonym: 3',5'-Cyclic diguanylic acid;   3',5'-cyclic di-GMP;   Bis-(3',5')-cyclic diGMP;   Cyclic di-3',5'-guanylate;   Formula=C20H24N10O14P2;   InChI=1S/C20H24N10O14P2/c21-19-25-13-7(15(33)27-19)23-3-29(13)17-9(31)11-5(41-17)1-39-45(35,36)44-12-6(2-40-46(37,38)43-11)42-18(10(12)32)30-4-24-8-14(30)26-20(22)28-16(8)34/h3-6,9-12,17-18,31-32H,1-2H2,(H,35,36)(H,37,38)(H3,21,25,27,33)(H3,22,26,28,34)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1;   InChIKey=PKFDLKSEZWEFGL-MHARETSRSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@H]2[C@H]1O)O[C@H]([C@@H]3O)n1cnc2c1nc(N)[nH]c2=O;   bis-(3'-5')-cyclic dimeric guanosine monophosphate;   c-(GpGp);   cGpGp;   cdiGMP;   cyclic di-3',5'-guanylic acid;   cyclic di-GMP;   cyclic diguanylic acid;   cyclic dinucleotide di-GMP;   cyclic-bis(3',5')diguanylic acid;   cyclic-bis(3'->5') dimeric GMP;   guanylyl-(3'->5')-3'-guanylic acid, cyclic 3'->5'''-nucleotide
 alt_id: CHEBI:47036;   CHEBI:49535
 xref: Beilstein:9696190;   CAS:61093-23-0;   KEGG:C16463
 xref_mesh: MESH:C062025
 xref: MetaCyc:C-DI-GMP;   PMID:17646358;   PMID:19691499;   PMID:20577685;   PMID:21320509;   PMID:22021215;   PMID:22661686;   PMID:22728658;   PMID:22728659;   PMID:22728660;   PMID:22821967;   PMID:23021863;   PMID:23023210;   PMID:23202856;   PMID:23289502;   PMID:23299943;   Reaxys:9606190
 cyclic_relationship: is_conjugate_acid_of CHEBI:58805


show annotations for term's descendants           Sort by:
c-di-GMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdrd7 tudor domain containing 7 increases expression ISO bis(3',5')-cyclic diguanylic acid results in increased expression of TDRD7 mRNA CTD PMID:32273341 NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        immunomodulator 15067
          c-di-GMP 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              oxoacid 18777
                                pnictogen oxoacid 14974
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13926
                                      phosphoric acid 13926
                                        phosphoric acid derivative 13835
                                          phosphate 13834
                                            organic phosphate 13834
                                              carbohydrate phosphate 1965
                                                phospho sugar 1810
                                                  aldose phosphate 1807
                                                    aldopentose phosphate 1799
                                                      ribose phosphate 1794
                                                        ribonucleotide 1756
                                                          purine ribonucleotide 1713
                                                            guanyl ribonucleotide 149
                                                              c-di-GMP 1
paths to the root