CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: beryllium difluoride
Accession: CHEBI:49499
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Definition: The fluoride salt of beryllium (+2 oxidation state). In the solid state it exists as a glass, with four-coordinate Be(2+) tetrahedral centres and two-coordinate fluoride centres. As a gas it adopts a linear triatomic structure and in the liquid state a fluctuating tetrahedral structure. In protein crystallography it is used as a mimic of phosphate.
Synonyms: related_synonym: Be2F4; BeF2; Beryllium fluoride; Berylliumfluorid; Formula=BeF2; InChI=1S/Be.2FH/h;2*1H/q+2;;/p-2; InChIKey=JZKFIPKXQBZXMW-UHFFFAOYSA-L; SMILES=F[Be]F
xref: CAS:7787-49-7; Gmelin:95146
xref_mesh: MESH:C035982
xref: MetaCyc:CPD0-1230; PMID:11897645; PMID:1551879; PMID:16223284; PMID:16771419; PMID:16771420; PMID:17963376; PMID:17979355; PMID:18651739; PMID:19561071; PMID:20529842; PMID:20572721; PMID:21141831; PMID:2808407; PMID:8800204; Reaxys:14667390
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Abcb1a
ATP-binding cassette, sub-family B member 1A
multiple interactions
ISO
beryllium fluoride promotes the reaction [ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate]
CTD
PMID:11027628
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcc6
ATP-binding cassette, sub-family C member 6
multiple interactions
ISO
beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Cobalt promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Magnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Nickel promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]
CTD
PMID:12069597
NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
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Abcc8
ATP-binding cassette, sub-family C member 8
decreases activity
ISO
beryllium fluoride results in decreased activity of ABCC8 protein
CTD
PMID:17561960 PMID:18025464
NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457
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Creb1
cAMP responsive element binding protein 1
increases expression
EXP
beryllium fluoride results in increased expression of CREB1 protein
CTD
PMID:11867686
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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Fos
FBJ osteosarcoma oncogene
increases expression
EXP
beryllium fluoride results in increased expression of FOS protein
CTD
PMID:11867686
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Map2k1
mitogen-activated protein kinase kinase 1
increases phosphorylation
EXP
beryllium fluoride results in increased phosphorylation of MAP2K1 protein
CTD
PMID:11867686
NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
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Mapk3
mitogen-activated protein kinase 3
increases phosphorylation
EXP
beryllium fluoride results in increased phosphorylation of MAPK3 protein
CTD
PMID:11867686
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Myc
myelocytomatosis oncogene
increases expression
EXP
beryllium fluoride results in increased expression of MYC protein
CTD
PMID:11867686
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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