CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: euxanthone
Accession: CHEBI:4946
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Definition: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense.
Synonyms: exact_synonym: 1,7-dihydroxy-9H-xanthen-9-one
related_synonym: 1,7-Dihydroxyxanthone; Formula=C13H8O4; InChI=1S/C13H8O4/c14-7-4-5-10-8(6-7)13(16)12-9(15)2-1-3-11(12)17-10/h1-6,14-15H; InChIKey=KDXFPEKLLFWHMN-UHFFFAOYSA-N; SMILES=Oc1ccc2oc3cccc(O)c3c(=O)c2c1; eyxanthone; purrenone
alt_id: CHEBI:67552
xref: CAS:529-61-3; HMDB:HMDB0030724; KEGG:C10061; KNApSAcK:C00002949; KNApSAcK:C00029364
xref_mesh: MESH:C404221
xref: PMID:10665986; PMID:11488451; PMID:12451499; PMID:16678494; PMID:17825492; PMID:20097048; PMID:21428375; Reaxys:207044
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
CTD
PMID:34655103
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Il6
interleukin 6
multiple interactions
ISO
euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD
PMID:34655103
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
multiple interactions
ISO
euxanthone inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]
CTD
PMID:34655103
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
G
Myd88
MYD88, innate immune signal transduction adaptor
multiple interactions
ISO
euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]
CTD
PMID:34655103
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Tlr4
toll-like receptor 4
multiple interactions
ISO
euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
CTD
PMID:34655103
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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