Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ionone
go back to main search page
Accession:CHEBI:49248 term browser browse the term
Synonyms:related_synonym: ionones


show annotations for term's descendants           Sort by:
alpha-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions		 ISO GNA15 protein results in increased susceptibility to alpha-ionone
[GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein		 CTD PMID:15598656 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508 		JBrowse link
G Olr59 olfactory receptor 59 decreases activity ISO alpha-ionone results in decreased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179 		JBrowse link
G Or1a1 olfactory receptor family 1 subfamily A member 1 multiple interactions ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein CTD PMID:15598656 NCBI chr10:59,058,941...59,059,879
Ensembl chr10:59,052,828...59,060,676 		JBrowse link
beta-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO beta-ionone results in increased expression of BAX protein CTD PMID:31506784 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO beta-ionone results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; Hydroxychloroquine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; STK11 protein affects the reaction [beta-ionone results in decreased expression of BCL2 protein]		 CTD PMID:23100158 PMID:31506784 PMID:36843289 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage		 ISO [alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein
beta-ionone results in increased expression of CASP3 protein modified form
beta-ionone results in increased cleavage of CASP3 protein		 CTD PMID:17618090 PMID:23100158 PMID:31506784 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO beta-ionone results in increased cleavage of CASP9 protein CTD PMID:36843289 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO beta-ionone results in decreased expression of CCND1 protein CTD PMID:15450939 PMID:31506784 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO beta-ionone results in decreased expression of CDK2 protein CTD PMID:15450939 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO beta-ionone results in decreased expression of CDK4 protein CTD PMID:15450939 PMID:31506784 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cryz crystallin zeta increases activity ISO beta-ionone results in increased activity of CRYZ protein CTD PMID:31506784 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Lmnb1 lamin B1 decreases farnesylation ISO beta-ionone results in decreased farnesylation of LMNB1 protein CTD PMID:10203554 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 3-methyladenine inhibits the reaction [beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein]; beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein; STK11 protein affects the reaction [beta-ionone results in increased lipidation of MAP1LC3B protein] CTD PMID:36843289 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO beta-ionone results in increased phosphorylation of MAPK1 protein
beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]		 CTD PMID:23268108 PMID:27226631 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]
beta-ionone results in increased phosphorylation of MAPK3 protein		 CTD PMID:23268108 PMID:27226631 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:23268108 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23268108 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Olr59 olfactory receptor 59 multiple interactions ISO beta-ionone binds to and results in increased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO 3-methyladenine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; STK11 protein affects the reaction [beta-ionone results in increased cleavage of PARP1 protein] CTD PMID:36843289 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
beta-ionone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:23268108 PMID:31506784 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:23268108 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation
multiple interactions		 ISO beta-ionone results in increased phosphorylation of STK11 protein
STK11 protein affects the reaction [beta-ionone results in decreased expression of BCL2 protein]; STK11 protein affects the reaction [beta-ionone results in increased cleavage of PARP1 protein]; STK11 protein affects the reaction [beta-ionone results in increased lipidation of MAP1LC3B protein]		 CTD PMID:36843289 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:23268108 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyr tyrosinase increases expression ISO beta-ionone results in increased expression of TYR mRNA; beta-ionone results in increased expression of TYR protein CTD PMID:27226631 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          volatile oil component 7791
            ionone 24
              alpha-ionone + 3
              beta-ionone + 22
              gamma-ionone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            organic hydride 18691
                              organic fundamental parent 18691
                                hydrocarbon 18442
                                  terpene 14066
                                    monoterpene 3831
                                      monoterpenoid 2042
                                        apo carotenoid monoterpenoid 47
                                          ionone 24
                                            alpha-ionone + 3
                                            beta-ionone + 22
                                            gamma-ionone + 0
paths to the root