CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: CETP inhibitor
Accession: CHEBI:49205
browse the term
Definition: Any inhibitor of cholesterylester transfer protein (CETP), which transfers cholesterol from high density lipoproteins (HDL, the 'good' cholesterol-containing particles) to low or very low density lipoproteins (LDL or VLDL, the 'bad' cholesterol-containing particles). Inhibition of this process results in higher HDL levels and lower LDL levels. CETP inhibitors are under investigation as potential drugs to reduce the risk of arteriosclerotic vascular disease (atherosclerosis).
Synonyms: related_synonym: CETP inhibitors; cholesteryl ester transfer protein inhibitor
xref: Wikipedia:CETP_inhibitor
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases expression
EXP
rosuvastatin increases Nr1h4 mRNA expression in rat kidney and liver
RGD
PMID:30308196
RGD:15042865
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Abca1
ATP binding cassette subfamily A member 1
decreases expression multiple interactions
ISO
Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]
CTD
PMID:18192897
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO EXP
Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid] [Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium
CTD
PMID:15901796 PMID:19853032
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions affects secretion increases expression
ISO EXP
ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein] ABCC2 protein affects the secretion of Rosuvastatin Calcium [Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein] Rosuvastatin Calcium results in increased expression of ABCC2 protein
CTD
PMID:19853032 PMID:23562342 PMID:24909372
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Rosuvastatin Calcium results in increased expression of ABCC3 protein
CTD
PMID:24909372
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg1
ATP binding cassette subfamily G member 1
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA
CTD
PMID:18192897
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions increases activity
EXP ISO
[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium Rosuvastatin Calcium results in increased activity of ABCG2 protein
CTD
PMID:19853032 PMID:30083819
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Ache
acetylcholinesterase
multiple interactions
EXP
[Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]
CTD
PMID:28441890
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Akt1
AKT serine/threonine kinase 1
affects phosphorylation
EXP
Rosuvastatin Calcium affects the phosphorylation of AKT1 protein
CTD
PMID:27815113
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Apoa1
apolipoprotein A1
multiple interactions increases expression
ISO
Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein]
CTD
PMID:12767421 PMID:15539964
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apob
apolipoprotein B
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of APOB protein
CTD
PMID:15539964 PMID:18702965
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]
CTD
PMID:32007421
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of BCL2 protein
CTD
PMID:20852871
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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C3
complement C3
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of C3 mRNA
CTD
PMID:32771489
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Casp3
caspase 3
increases activity increases expression
ISO
Rosuvastatin Calcium results in increased activity of CASP3 protein Rosuvastatin Calcium results in increased expression of CASP3 protein
CTD
PMID:21478229 PMID:32771489
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
increases activity multiple interactions
EXP
Rosuvastatin Calcium results in increased activity of CAT protein [Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD
PMID:20146376 PMID:32007421 PMID:35130744
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
decreases expression
EXP
Rosuvastatin Calcium results in decreased expression of CCL2 mRNA
CTD
PMID:15681303
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Creb5
cAMP responsive element binding protein 5
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of CREB5 mRNA
CTD
PMID:18192897
NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
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Crp
C-reactive protein
multiple interactions
ISO
Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]
CTD
PMID:21562509
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cyba
cytochrome b-245 alpha chain
multiple interactions decreases expression
EXP
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species
CTD
PMID:21562509
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Cybb
cytochrome b-245 beta chain
multiple interactions decreases expression
ISO EXP
Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA] Rosuvastatin Calcium results in decreased expression of CYBB [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species
CTD
PMID:16633368 PMID:21562509
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Esr1
estrogen receptor 1
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of ESR1 protein
CTD
PMID:32771489
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression multiple interactions
ISO
Rosuvastatin Calcium results in increased expression of GCLC mRNA [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA
CTD
PMID:18154958
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gpr183
G protein-coupled receptor 183
multiple interactions increases expression
ISO
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA]
CTD
PMID:18192897
NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
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Gzmk
granzyme K
multiple interactions increases expression
ISO
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA]
CTD
PMID:18192897
NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894
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Hnf4a
hepatocyte nuclear factor 4, alpha
increases secretion
ISO
HNF4A protein results in increased secretion of Rosuvastatin Calcium
CTD
PMID:27160211
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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Il18rap
interleukin 18 receptor accessory protein
decreases expression multiple interactions
ISO
Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]
CTD
PMID:18192897
NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
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Il1b
interleukin 1 beta
decreases expression
EXP
Rosuvastatin Calcium results in decreased expression of IL1B mRNA
CTD
PMID:15681303
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Rosuvastatin Calcium results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnj15
potassium inwardly-rectifying channel, subfamily J, member 15
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA
CTD
PMID:18192897
NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952
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Kdr
kinase insert domain receptor
multiple interactions
ISO
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]
CTD
PMID:27097221
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Mb
myoglobin
affects expression
EXP
Rosuvastatin Calcium affects the expression of MB protein
CTD
PMID:27815113
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Mstn
myostatin
increases expression
ISO
Rosuvastatin Calcium results in increased expression of MSTN protein
CTD
PMID:33034787
NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]
CTD
PMID:32007421 PMID:35130744
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
increases expression multiple interactions
EXP
Rosuvastatin Calcium results in increased expression of NOS2 mRNA Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]
CTD
PMID:21443142 PMID:32007421 PMID:35130744
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
multiple interactions affects response to substance increases expression
ISO EXP
Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein NOS3 protein affects the susceptibility to Rosuvastatin Calcium Rosuvastatin Calcium results in increased expression of NOS3 mRNA
CTD
PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Orm1
orosomucoid 1
multiple interactions decreases expression
ISO
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA]
CTD
PMID:18192897
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Pecam1
platelet and endothelial cell adhesion molecule 1
multiple interactions
ISO
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]
CTD
PMID:27097221
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Selp
selectin P
decreases expression
EXP
Rosuvastatin Calcium results in decreased expression of SELP mRNA
CTD
PMID:15681303
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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Serpine2
serpin family E member 2
multiple interactions
ISO
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD
PMID:27097221
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Slco1a4
solute carrier organic anion transporter family, member 1a4
multiple interactions affects transport decreases expression increases uptake
EXP ISO
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] SLCO1A4 protein affects the transport of Rosuvastatin Calcium Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
CTD
PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2
solute carrier organic anion transporter family member 1B2
multiple interactions increases uptake
EXP ISO
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium] SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
CTD
PMID:26888941 PMID:31299240
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Slco2b1
solute carrier organic anion transporter family, member 2b1
increases uptake multiple interactions
ISO
SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]
CTD
PMID:24285294
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Sod1
superoxide dismutase 1
multiple interactions increases expression
EXP
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species
CTD
PMID:21562509
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Tff1
trefoil factor 1
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of TFF1 mRNA
CTD
PMID:32771489
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tgfb1
transforming growth factor, beta 1
multiple interactions decreases expression
ISO EXP
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA
CTD
PMID:15681303 PMID:27097221
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
decreases expression multiple interactions
EXP
Rosuvastatin Calcium results in decreased expression of TNF mRNA Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
CTD
PMID:15681303 PMID:32007421 PMID:35130744
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnni3
troponin I3, cardiac type
multiple interactions
EXP
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]
CTD
PMID:32007421 PMID:35130744
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Vnn3
vanin 3
decreases expression
ISO
Rosuvastatin Calcium results in decreased expression of VNN3P mRNA
CTD
PMID:18192897
NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626
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Wt1
WT1 transcription factor
increases expression
EXP
Rosuvastatin Calcium results in increased expression of WT1 mRNA
CTD
PMID:21443142
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
increases expression
ISO
torcetrapib results in increased expression of AASDHPPT mRNA
CTD
PMID:23228038
NCBI chr 8:1,453,226...1,463,990
Ensembl chr 8:1,452,282...1,463,966
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Aff2
ALF transcription elongation factor 2
increases expression
ISO
torcetrapib results in increased expression of AFF2 mRNA
CTD
PMID:23228038
NCBI chr X:147,928,130...148,432,484
Ensembl chr X:147,928,407...148,429,995
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Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
increases expression
ISO
torcetrapib results in increased expression of AGPAT3 mRNA
CTD
PMID:23228038
NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358
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Ahctf1
AT hook containing transcription factor 1
increases expression
ISO
torcetrapib results in increased expression of AHCTF1 mRNA
CTD
PMID:23228038
NCBI chr13:91,481,936...91,536,391
Ensembl chr13:91,481,936...91,536,391
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Akirin1
akirin 1
increases expression
ISO
torcetrapib results in increased expression of AKIRIN1 mRNA
CTD
PMID:23228038
NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762
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Akt2
AKT serine/threonine kinase 2
increases expression
ISO
torcetrapib results in increased expression of AKT2 mRNA
CTD
PMID:23228038
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Akt3
AKT serine/threonine kinase 3
increases expression
ISO
torcetrapib results in increased expression of AKT3 mRNA
CTD
PMID:23228038
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Ammecr1
AMMECR nuclear protein 1
increases expression
ISO
torcetrapib results in increased expression of AMMECR1 mRNA
CTD
PMID:23228038
NCBI chr X:106,465,982...106,571,382
Ensembl chr X:106,466,699...106,571,487
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Amotl1
angiomotin-like 1
increases expression
ISO
torcetrapib results in increased expression of AMOTL1 mRNA
CTD
PMID:23228038
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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Angpt1
angiopoietin 1
increases expression
ISO
torcetrapib results in increased expression of ANGPT1 mRNA
CTD
PMID:23228038
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Ank3
ankyrin 3
increases expression
ISO
torcetrapib results in increased expression of ANK3 mRNA
CTD
PMID:23228038
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Ankrd11
ankyrin repeat domain containing 11
increases expression
ISO
torcetrapib results in increased expression of ANKRD11 mRNA
CTD
PMID:23228038
NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962
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Anxa1
annexin A1
increases expression
ISO
torcetrapib results in increased expression of ANXA1 mRNA
CTD
PMID:23228038
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Ap3d1
adaptor related protein complex 3 subunit delta 1
increases expression
ISO
torcetrapib results in increased expression of AP3D1 mRNA
CTD
PMID:23228038
NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643
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Apbb2
amyloid beta precursor protein binding family B member 2
increases expression
ISO
torcetrapib results in increased expression of APBB2 mRNA
CTD
PMID:23228038
NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495
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Appl1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
increases expression
ISO
torcetrapib results in increased expression of APPL1 mRNA
CTD
PMID:23228038
NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
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Arg2
arginase 2
increases expression
ISO
torcetrapib results in increased expression of ARG2 mRNA
CTD
PMID:23228038
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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Arhgap29
Rho GTPase activating protein 29
increases expression
ISO
torcetrapib results in increased expression of ARHGAP29 mRNA
CTD
PMID:23228038
NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
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Arid4b
AT-rich interaction domain 4B
increases expression
ISO
torcetrapib results in increased expression of ARID4B mRNA
CTD
PMID:23228038
NCBI chr17:51,138,419...51,262,894
Ensembl chr17:51,138,535...51,262,906
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Arl5b
ARF like GTPase 5B
increases expression
ISO
torcetrapib results in increased expression of ARL5B mRNA
CTD
PMID:23228038
NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854
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Atf3
activating transcription factor 3
increases expression
ISO
torcetrapib results in increased expression of ATF3 mRNA
CTD
PMID:23228038
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atg12
autophagy related 12
increases expression
ISO
torcetrapib results in increased expression of ATG12 mRNA
CTD
PMID:23228038
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
increases expression
ISO
torcetrapib results in increased expression of ATP2A2 mRNA
CTD
PMID:23228038
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Atrx
ATRX, chromatin remodeler
increases expression
ISO
torcetrapib results in increased expression of ATRX mRNA
CTD
PMID:23228038
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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Atxn7l3b
ataxin 7-like 3B
increases expression
ISO
torcetrapib results in increased expression of ATXN7L3B mRNA
CTD
PMID:23228038
NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878
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Bdnf
brain-derived neurotrophic factor
increases expression
ISO
torcetrapib results in increased expression of BDNF mRNA
CTD
PMID:23228038
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bicd2
BICD cargo adaptor 2
increases expression
ISO
torcetrapib results in increased expression of BICD2 mRNA
CTD
PMID:23228038
NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889
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Bod1l1
biorientation of chromosomes in cell division 1-like 1
increases expression
ISO
torcetrapib results in increased expression of BOD1L mRNA
CTD
PMID:23228038
NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
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Brcc3
BRCA1/BRCA2-containing complex subunit 3
increases expression
ISO
torcetrapib results in increased expression of BRCC3 mRNA
CTD
PMID:23228038
NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
torcetrapib results in increased expression of BTG2 mRNA
CTD
PMID:23228038
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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C17h5orf24
similar to human chromosome 5 open reading frame 24
increases expression
ISO
torcetrapib results in increased expression of C5ORF24 mRNA
CTD
PMID:23228038
NCBI chr17:8,923,041...8,932,958
Ensembl chr17:8,922,675...8,933,356
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C3h11orf96
similar to human chromosome 11 open reading frame 96
increases expression
ISO
torcetrapib results in increased expression of C11ORF96 mRNA
CTD
PMID:23228038
NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
increases expression
ISO
torcetrapib results in increased expression of CACNA1C mRNA
CTD
PMID:20498617
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacul1
CDK2-associated, cullin domain 1
increases expression
ISO
torcetrapib results in increased expression of CACUL1 mRNA
CTD
PMID:23228038
NCBI chr 1:259,666,335...259,726,249
Ensembl chr 1:259,668,516...259,726,082
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Cald1
caldesmon 1
increases expression
ISO
torcetrapib results in increased expression of CALD1 mRNA
CTD
PMID:23228038
NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
increases expression
ISO
torcetrapib results in increased expression of CAMK2D mRNA
CTD
PMID:23228038
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Cask
calcium/calmodulin dependent serine protein kinase
increases expression
ISO
torcetrapib results in increased expression of CASK mRNA
CTD
PMID:23228038
NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694
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Cbl
Cbl proto-oncogene
increases expression
ISO
torcetrapib results in increased expression of CBL mRNA
CTD
PMID:23228038
NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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Ccdc88a
coiled coil domain containing 88A
increases expression
ISO
torcetrapib results in increased expression of CCDC88A mRNA
CTD
PMID:23228038
NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368
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Ccn1
cellular communication network factor 1
increases expression
ISO
torcetrapib results in increased expression of CCN1 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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Ccsap
centriole, cilia and spindle-associated protein
increases expression
ISO
torcetrapib results in increased expression of CCSAP mRNA
CTD
PMID:23228038
NCBI chr19:51,824,954...51,843,469
Ensembl chr19:51,826,994...51,842,753
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Ccser2
coiled-coil serine-rich protein 2
increases expression
ISO
torcetrapib results in increased expression of CCSER2 mRNA
CTD
PMID:23228038
NCBI chr16:12,613,103...12,725,764
Ensembl chr16:12,613,103...12,725,738
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Cd47
Cd47 molecule
increases expression
ISO
torcetrapib results in increased expression of CD47 mRNA
CTD
PMID:23228038
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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Cd55
CD55 molecule (Cromer blood group)
increases expression
ISO
torcetrapib results in increased expression of CD55 mRNA
CTD
PMID:23228038
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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Cdk14
cyclin-dependent kinase 14
increases expression
ISO
torcetrapib results in increased expression of CDK14 mRNA
CTD
PMID:23228038
NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861
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Cdk6
cyclin-dependent kinase 6
increases expression
ISO
torcetrapib results in increased expression of CDK6 mRNA
CTD
PMID:23228038
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cep89
centrosomal protein 89
increases expression
ISO
torcetrapib results in increased expression of CEP89 mRNA
CTD
PMID:23228038
NCBI chr 1:88,058,211...88,100,114
Ensembl chr 1:88,058,227...88,100,112
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Chd4
chromodomain helicase DNA binding protein 4
increases expression
ISO
torcetrapib results in increased expression of CHD4 mRNA
CTD
PMID:23228038
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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Chd9
chromodomain helicase DNA binding protein 9
increases expression
ISO
torcetrapib results in increased expression of CHD9 mRNA
CTD
PMID:23228038
NCBI chr19:15,941,535...16,146,220
Ensembl chr19:15,942,687...16,164,556
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Chml
CHM like Rab escort protein
increases expression
ISO
torcetrapib results in increased expression of CHML mRNA
CTD
PMID:23228038
NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862
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Cimip2b
ciliary microtubule inner protein 2B
increases expression
ISO
torcetrapib results in increased expression of CIMIP2B mRNA
CTD
PMID:23228038
NCBI chr 5:57,675,537...57,680,133
Ensembl chr 5:57,675,462...57,678,611
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Cln5
CLN5, intracellular trafficking protein
increases expression
ISO
torcetrapib results in increased expression of CLN5 mRNA
CTD
PMID:23228038
NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 Ensembl chr 2:79,893,548...79,903,438
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Cnot6l
CCR4-NOT transcription complex, subunit 6-like
increases expression
ISO
torcetrapib results in increased expression of CNOT6L mRNA
CTD
PMID:23228038
NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203
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Cnst
consortin, connexin sorting protein
increases expression
ISO
torcetrapib results in increased expression of CNST mRNA
CTD
PMID:23228038
NCBI chr13:91,296,740...91,373,531
Ensembl chr13:91,296,142...91,373,531
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Cpeb4
cytoplasmic polyadenylation element binding protein 4
increases expression
ISO
torcetrapib results in increased expression of CPEB4 mRNA
CTD
PMID:23228038
NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603
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Crem
cAMP responsive element modulator
increases expression
ISO
torcetrapib results in increased expression of CREM mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Csnk1g1
casein kinase 1, gamma 1
increases expression
ISO
torcetrapib results in increased expression of CSNK1G1 mRNA
CTD
PMID:23228038
NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826
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Csrnp1
cysteine and serine rich nuclear protein 1
increases expression
ISO
torcetrapib results in increased expression of CSRNP1 mRNA
CTD
PMID:23228038
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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Csrnp3
cysteine and serine rich nuclear protein 3
increases expression
ISO
torcetrapib results in increased expression of CSRNP3 mRNA
CTD
PMID:23228038
NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950
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Cth
cystathionine gamma-lyase
increases expression
ISO
torcetrapib results in increased expression of CTH mRNA
CTD
PMID:23228038
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Cxadr
CXADR, Ig-like cell adhesion molecule
increases expression
ISO
torcetrapib results in increased expression of CXADR mRNA
CTD
PMID:23228038
NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046
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Cybb
cytochrome b-245 beta chain
increases expression
ISO
torcetrapib results in increased expression of CYBB protein
CTD
PMID:25617244
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cycs
cytochrome c, somatic
increases expression
ISO
torcetrapib results in increased expression of CYCS mRNA
CTD
PMID:23228038
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
ISO
torcetrapib results in increased expression of CYP11A1 mRNA
CTD
PMID:28235592
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
increases expression multiple interactions
ISO
torcetrapib results in increased expression of CYP11B1 mRNA Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]
CTD
PMID:19164467 PMID:25617244 PMID:28235592
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; NSC 74859 inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA] torcetrapib results in increased expression of CYP11B2 mRNA; torcetrapib results in increased expression of CYP11B2 protein
CTD
PMID:19164467 PMID:20498617 PMID:25617244 PMID:28235592
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression
ISO
torcetrapib results in increased expression of CYP17A1 mRNA
CTD
PMID:28235592
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyren
cell cycle regulator of NHEJ
increases expression
ISO
torcetrapib results in increased expression of CYREN mRNA
CTD
PMID:23228038
NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602
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Dbt
dihydrolipoamide branched chain transacylase E2
increases expression
ISO
torcetrapib results in increased expression of DBT mRNA
CTD
PMID:23228038
NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
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Dcaf16
DDB1 and CUL4 associated factor 16
increases expression
ISO
torcetrapib results in increased expression of DCAF16 mRNA
CTD
PMID:23228038
NCBI chr14:65,449,631...65,450,015
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Dcaf7
DDB1 and CUL4 associated factor 7
increases expression
ISO
torcetrapib results in increased expression of DCAF7 mRNA
CTD
PMID:23228038
NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275
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Dctn5
dynactin subunit 5
increases expression
ISO
torcetrapib results in increased expression of DCTN5 mRNA
CTD
PMID:23228038
NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
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Dnajb14
DnaJ heat shock protein family (Hsp40) member B14
increases expression
ISO
torcetrapib results in increased expression of DNAJB14 mRNA
CTD
PMID:23228038
NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490
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Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
increases expression
ISO
torcetrapib results in increased expression of DNAJC12 mRNA
CTD
PMID:23228038
NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
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Dnajc13
DnaJ heat shock protein family (Hsp40) member C13
increases expression
ISO
torcetrapib results in increased expression of DNAJC13 mRNA
CTD
PMID:23228038
NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317
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Dst
dystonin
increases expression
ISO
torcetrapib results in increased expression of DST mRNA
CTD
PMID:23228038
NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
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Dusp1
dual specificity phosphatase 1
increases expression
ISO
torcetrapib results in increased expression of DUSP1 mRNA
CTD
PMID:23228038
NCBI chr10:16,680,478...16,683,275
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Dusp16
dual specificity phosphatase 16
increases expression
ISO
torcetrapib results in increased expression of DUSP16 mRNA
CTD
PMID:23228038
NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980
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Dync1h1
dynein cytoplasmic 1 heavy chain 1
increases expression
ISO
torcetrapib results in increased expression of DYNC1H1 mRNA
CTD
PMID:23228038
NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
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Ece1
endothelin converting enzyme 1
increases expression
ISO
torcetrapib results in increased expression of ECE1 mRNA
CTD
PMID:23228038
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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Edn1
endothelin 1
multiple interactions
EXP
torcetrapib affects the expression of and affects the activity of EDN1 protein
CTD
PMID:21920972
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Edrf1
erythroid differentiation regulatory factor 1
increases expression
ISO
torcetrapib results in increased expression of EDRF1 mRNA
CTD
PMID:23228038
NCBI chr 1:188,441,514...188,478,743
Ensembl chr 1:188,441,634...188,478,701
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Egln1
egl-9 family hypoxia-inducible factor 1
increases expression
ISO
torcetrapib results in increased expression of EGLN1 mRNA
CTD
PMID:23228038
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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Ehbp1
EH domain binding protein 1
increases expression
ISO
torcetrapib results in increased expression of EHBP1 mRNA
CTD
PMID:23228038
NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
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Eid1
EP300 interacting inhibitor of differentiation 1
increases expression
ISO
torcetrapib results in increased expression of EID1 mRNA
CTD
PMID:23228038
NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752
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Eif4g1
eukaryotic translation initiation factor 4 gamma 1
increases expression
ISO
torcetrapib results in increased expression of EIF4G1 mRNA
CTD
PMID:23228038
NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
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Elf1
E74 like ETS transcription factor 1
increases expression
ISO
torcetrapib results in increased expression of ELF1 mRNA
CTD
PMID:23228038
NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
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Ep400
E1A binding protein p400
increases expression
ISO
torcetrapib results in increased expression of EP400 mRNA
CTD
PMID:23228038
NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
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Eppk1
epiplakin 1
increases expression
ISO
torcetrapib results in increased expression of EPPK1 mRNA
CTD
PMID:23228038
NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159
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Erc1
ELKS/RAB6-interacting/CAST family member 1
increases expression
ISO
torcetrapib results in increased expression of ERC1 mRNA
CTD
PMID:23228038
NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639
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Exd2
exonuclease 3'-5' domain containing 2
increases expression
ISO
torcetrapib results in increased expression of EXD2 mRNA
CTD
PMID:23228038
NCBI chr 6:100,116,867...100,150,452
Ensembl chr 6:100,116,867...100,150,442
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Exosc6
exosome component 6
increases expression
ISO
torcetrapib results in increased expression of EXOSC6 mRNA
CTD
PMID:23228038
NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
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Fam114a1
family with sequence similarity 114, member A1
increases expression
ISO
torcetrapib results in increased expression of FAM114A1 mRNA
CTD
PMID:23228038
NCBI chr14:43,275,693...43,346,154
Ensembl chr14:43,275,701...43,346,174
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Fancm
FA complementation group M
increases expression
ISO
torcetrapib results in increased expression of FANCM mRNA
CTD
PMID:23228038
NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028
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Fbxl4
F-box and leucine-rich repeat protein 4
increases expression
ISO
torcetrapib results in increased expression of FBXL4 mRNA
CTD
PMID:23228038
NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443
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Fbxo28
F-box protein 28
increases expression
ISO
torcetrapib results in increased expression of FBXO28 mRNA
CTD
PMID:23228038
NCBI chr13:93,995,993...94,021,464
Ensembl chr13:93,995,996...94,021,464
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Fgf9
fibroblast growth factor 9
increases expression
ISO
torcetrapib results in increased expression of FGF9 mRNA
CTD
PMID:23228038
NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
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Fkbp10
FKBP prolyl isomerase 10
increases expression
ISO
torcetrapib results in increased expression of FKBP10 mRNA
CTD
PMID:23228038
NCBI chr10:85,345,434...85,357,998
Ensembl chr10:85,346,126...85,427,330
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Flrt2
fibronectin leucine rich transmembrane protein 2
increases expression
ISO
torcetrapib results in increased expression of FLRT2 mRNA
CTD
PMID:23228038
NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of FOS mRNA
CTD
PMID:23228038
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosl2
FOS like 2, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of FOSL2 mRNA
CTD
PMID:23228038
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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Fsd1l
fibronectin type III and SPRY domain containing 1-like
increases expression
ISO
torcetrapib results in increased expression of FSD1L mRNA
CTD
PMID:23228038
NCBI chr 5:68,258,877...68,334,931
Ensembl chr 5:68,258,932...68,334,928
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Fzd10
frizzled class receptor 10
increases expression
ISO
torcetrapib results in increased expression of FZD10 mRNA
CTD
PMID:23228038
NCBI chr12:28,098,371...28,101,566
Ensembl chr12:28,098,371...28,101,566
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
torcetrapib results in increased expression of GADD45A mRNA
CTD
PMID:23228038
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gem
GTP binding protein overexpressed in skeletal muscle
increases expression
ISO
torcetrapib results in increased expression of GEM mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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Git2
GIT ArfGAP 2
increases expression
ISO
torcetrapib results in increased expression of GIT2 mRNA
CTD
PMID:23228038
NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
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Glipr1
GLI pathogenesis-related 1
increases expression
ISO
torcetrapib results in increased expression of GLIPR1 mRNA
CTD
PMID:23228038
NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429
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Gng12
G protein subunit gamma 12
increases expression
ISO
torcetrapib results in increased expression of GNG12 mRNA
CTD
PMID:23228038
NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
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Golga2
golgin A2
increases expression
ISO
torcetrapib results in increased expression of GOLGA2 mRNA
CTD
PMID:23228038
NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
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Golim4
golgi integral membrane protein 4
increases expression
ISO
torcetrapib results in increased expression of GOLIM4 mRNA
CTD
PMID:23228038
NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253
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H4f3
H1.3 linker histone, cluster member
increases expression
ISO
torcetrapib results in increased expression of H1-3 mRNA
CTD
PMID:23228038
NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334
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Hacd2
3-hydroxyacyl-CoA dehydratase 2
increases expression
ISO
torcetrapib results in increased expression of HACD2 mRNA
CTD
PMID:23228038
NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889
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Hapstr1
HUWE1 associated protein modifying stress responses
increases expression
ISO
torcetrapib results in increased expression of HAPSTR1 mRNA
CTD
PMID:23228038
NCBI chr10:6,746,037...6,774,992
Ensembl chr10:6,746,048...6,774,992
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Haus2
HAUS augmin like complex subunit 2
increases expression
ISO
torcetrapib results in increased expression of HAUS2 mRNA
CTD
PMID:23228038
NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157
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Heatr1
HEAT repeat containing 1
increases expression
ISO
torcetrapib results in increased expression of HEATR1 mRNA
CTD
PMID:23228038
NCBI chr17:58,053,288...58,093,895
Ensembl chr17:58,051,700...58,093,948
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Hectd1
HECT domain E3 ubiquitin protein ligase 1
increases expression
ISO
torcetrapib results in increased expression of HECTD1 mRNA
CTD
PMID:23228038
NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053
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Hfe
homeostatic iron regulator
increases expression
ISO
torcetrapib results in increased expression of HFE mRNA
CTD
PMID:23228038
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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Hipk2
homeodomain interacting protein kinase 2
increases expression
ISO
torcetrapib results in increased expression of HIPK2 mRNA
CTD
PMID:23228038
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
increases expression
ISO
torcetrapib results in increased expression of HSD3B2 mRNA
CTD
PMID:28235592
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
torcetrapib results in increased expression of HSPH1 mRNA
CTD
PMID:23228038
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Htatsf1
HIV-1 Tat specific factor 1
increases expression
ISO
torcetrapib results in increased expression of HTATSF1 mRNA
CTD
PMID:23228038
NCBI chr X:134,935,426...134,949,607
Ensembl chr X:134,935,426...134,949,607
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Id4
inhibitor of DNA binding 4
increases expression
ISO
torcetrapib results in increased expression of ID4 mRNA
CTD
PMID:23228038
NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
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Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
increases expression
ISO
torcetrapib results in increased expression of IGF2BP3 mRNA
CTD
PMID:23228038
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
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Il13ra1
interleukin 13 receptor subunit alpha 1
increases expression
ISO
torcetrapib results in increased expression of IL13RA1 mRNA
CTD
PMID:23228038
NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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Il6st
interleukin 6 cytokine family signal transducer
increases expression
ISO
torcetrapib results in increased expression of IL6ST mRNA
CTD
PMID:23228038
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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Ilf3
interleukin enhancer binding factor 3
increases expression
ISO
torcetrapib results in increased expression of ILF3 mRNA
CTD
PMID:23228038
NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350
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Ing3
inhibitor of growth family, member 3
increases expression
ISO
torcetrapib results in increased expression of ING3 mRNA
CTD
PMID:23228038
NCBI chr 4:50,477,954...50,505,168
Ensembl chr 4:50,477,962...50,503,715
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Inhba
inhibin subunit beta A
increases expression
ISO
torcetrapib results in increased expression of INHBA mRNA
CTD
PMID:23228038
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Ino80d
INO80 complex subunit D
increases expression
ISO
torcetrapib results in increased expression of INO80D mRNA
CTD
PMID:23228038
NCBI chr 9:64,447,075...64,514,013
Ensembl chr 9:64,457,165...64,515,242
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Irgq
immunity-related GTPase Q
increases expression
ISO
torcetrapib results in increased expression of IRGQ mRNA
CTD
PMID:23228038
NCBI chr 1:80,123,925...80,131,881
Ensembl chr 1:80,123,925...80,131,881
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Itch
itchy E3 ubiquitin protein ligase
increases expression
ISO
torcetrapib results in increased expression of ITCH mRNA
CTD
PMID:23228038
NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
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Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
increases expression
ISO
torcetrapib results in increased expression of ITPR2 mRNA
CTD
PMID:23228038
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
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Itprid2
ITPR interacting domain containing 2
increases expression
ISO
torcetrapib results in increased expression of ITPRID2 mRNA
CTD
PMID:23228038
NCBI chr 3:64,536,707...64,573,978
Ensembl chr 3:64,536,707...64,573,978
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Iws1
interacts with SUPT6H, CTD assembly factor 1
increases expression
ISO
torcetrapib results in increased expression of IWS1 mRNA
CTD
PMID:23228038
NCBI chr18:23,695,496...23,737,363
Ensembl chr18:23,695,425...23,736,172
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Jak1
Janus kinase 1
increases expression
ISO
torcetrapib results in increased expression of JAK1 mRNA
CTD
PMID:23228038
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Jpt2
Jupiter microtubule associated homolog 2
increases expression
ISO
torcetrapib results in increased expression of JPT2 mRNA
CTD
PMID:23228038
NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of JUN mRNA
CTD
PMID:23228038
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of JUNB mRNA
CTD
PMID:23228038
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Kitlg
KIT ligand
increases expression
ISO
torcetrapib results in increased expression of KITLG mRNA
CTD
PMID:23228038
NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
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Klf2
KLF transcription factor 2
increases expression
ISO
torcetrapib results in increased expression of KLF2 mRNA
CTD
PMID:23228038
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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Klf6
KLF transcription factor 6
increases expression
ISO
torcetrapib results in increased expression of KLF6 mRNA
CTD
PMID:23228038
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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Klf7
KLF transcription factor 7
increases expression
ISO
torcetrapib results in increased expression of KLF7 mRNA
CTD
PMID:23228038
NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
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Klhdc10
kelch domain containing 10
increases expression
ISO
torcetrapib results in increased expression of KLHDC10 mRNA
CTD
PMID:23228038
NCBI chr 4:59,021,300...59,079,118
Ensembl chr 4:59,021,310...59,074,941
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Klhl24
kelch-like family member 24
increases expression
ISO
torcetrapib results in increased expression of KLHL24 mRNA
CTD
PMID:23228038
NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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Kmt2a
lysine methyltransferase 2A
increases expression
ISO
torcetrapib results in increased expression of KMT2A mRNA
CTD
PMID:23228038
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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Lars1
leucyl-tRNA synthetase 1
increases expression
ISO
torcetrapib results in increased expression of LARS1 mRNA
CTD
PMID:23228038
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
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Lima1
LIM domain and actin binding 1
increases expression
ISO
torcetrapib results in increased expression of LIMA1 mRNA
CTD
PMID:23228038
NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473
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Lins1
lines homolog 1
increases expression
ISO
torcetrapib results in increased expression of LINS1 mRNA
CTD
PMID:23228038
NCBI chr 1:120,267,586...120,295,013
Ensembl chr 1:120,267,693...120,293,607
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Lonrf2
LON peptidase N-terminal domain and ring finger 2
increases expression
ISO
torcetrapib results in increased expression of LONRF2 mRNA
CTD
PMID:23228038
NCBI chr 9:41,033,125...41,070,551
Ensembl chr 9:41,034,628...41,070,649
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Lpcat2
lysophosphatidylcholine acyltransferase 2
increases expression
ISO
torcetrapib results in increased expression of LPCAT2 mRNA
CTD
PMID:23228038
NCBI chr19:14,088,389...14,152,742
Ensembl chr19:14,089,686...14,152,829
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Lrp12
LDL receptor related protein 12
increases expression
ISO
torcetrapib results in increased expression of LRP12 mRNA
CTD
PMID:23228038
NCBI chr 7:70,941,068...71,012,409
Ensembl chr 7:70,941,068...71,012,441
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Lsm14b
LSM family member 14B
increases expression
ISO
torcetrapib results in increased expression of LSM14B mRNA
CTD
PMID:23228038
NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432
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Lzic
leucine zipper and CTNNBIP1 domain containing
increases expression
ISO
torcetrapib results in increased expression of LZIC mRNA
CTD
PMID:23228038
NCBI chr 5:159,928,260...159,941,512
Ensembl chr 5:159,920,439...159,939,685
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M6pr
mannose-6-phosphate receptor, cation dependent
increases expression
ISO
torcetrapib results in increased expression of M6PR mRNA
CTD
PMID:23228038
NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
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Map3k2
mitogen activated protein kinase kinase kinase 2
increases expression
ISO
torcetrapib results in increased expression of MAP3K2 mRNA
CTD
PMID:23228038
NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
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Map4
microtubule-associated protein 4
increases expression
ISO
torcetrapib results in increased expression of MAP4 mRNA
CTD
PMID:23228038
NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
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Mbnl2
muscleblind-like splicing regulator 2
increases expression
ISO
torcetrapib results in increased expression of MBNL2 mRNA
CTD
PMID:23228038
NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937
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Mef2a
myocyte enhancer factor 2a
increases expression
ISO
torcetrapib results in increased expression of MEF2A mRNA
CTD
PMID:23228038
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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Mettl16
methyltransferase 16, RNA N6-adenosine
increases expression
ISO
torcetrapib results in increased expression of METTL16 mRNA
CTD
PMID:23228038
NCBI chr10:59,640,915...59,697,291
Ensembl chr10:59,640,972...59,687,061
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
torcetrapib results in increased expression of MITF mRNA
CTD
PMID:23228038
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Mkln1
muskelin 1
increases expression
ISO
torcetrapib results in increased expression of MKLN1 mRNA
CTD
PMID:23228038
NCBI chr 4:59,815,912...60,124,047
Ensembl chr 4:60,002,464...60,123,993
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Mras
muscle RAS oncogene homolog
increases expression
ISO
torcetrapib results in increased expression of MRAS mRNA
CTD
PMID:23228038
NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
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Myl12a
myosin light chain 12A
increases expression
ISO
torcetrapib results in increased expression of MYL12A mRNA
CTD
PMID:23228038
NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
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Myo6
myosin VI
increases expression
ISO
torcetrapib results in increased expression of MYO6 mRNA
CTD
PMID:23228038
NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292
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Myot
myotilin
increases expression
ISO
torcetrapib results in increased expression of MYOT mRNA
CTD
PMID:23228038
NCBI chr18:36,705,244...36,724,849
Ensembl chr18:36,705,314...36,724,841
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Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
increases expression
ISO
torcetrapib results in increased expression of NAA15 mRNA
CTD
PMID:23228038
NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
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Nab2
Ngfi-A binding protein 2
increases expression
ISO
torcetrapib results in increased expression of NAB2 mRNA
CTD
PMID:23228038
NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
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Ncoa3
nuclear receptor coactivator 3
increases expression
ISO
torcetrapib results in increased expression of NCOA3 mRNA
CTD
PMID:23228038
NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
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Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
increases expression
ISO
torcetrapib results in increased expression of NF2 mRNA
CTD
PMID:23228038
NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
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Nfatc2ip
nuclear factor of activated T-cells 2 interacting protein
increases expression
ISO
torcetrapib results in increased expression of NFATC2IP mRNA
CTD
PMID:23228038
NCBI chr 1:180,954,834...180,971,847
Ensembl chr 1:180,955,043...180,971,747
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
torcetrapib results in increased expression of NFE2L2 mRNA
CTD
PMID:23228038
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfil3
nuclear factor, interleukin 3 regulated
increases expression
ISO
torcetrapib results in increased expression of NFIL3 mRNA
CTD
PMID:23228038
NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
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Nfkbiz
NFKB inhibitor zeta
increases expression
ISO
torcetrapib results in increased expression of NFKBIZ mRNA
CTD
PMID:23228038
NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
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Nos3
nitric oxide synthase 3
decreases expression
EXP ISO
torcetrapib results in decreased expression of NOS3 mRNA; torcetrapib results in decreased expression of NOS3 protein
CTD
PMID:21920972
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nox1
NADPH oxidase 1
increases expression
ISO
torcetrapib results in increased expression of NOX1 mRNA; torcetrapib results in increased expression of NOX1 protein
CTD
PMID:25617244
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nox4
NADPH oxidase 4
increases expression
ISO
torcetrapib results in increased expression of NOX4 mRNA
CTD
PMID:25617244
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Npepps
aminopeptidase puromycin sensitive
increases expression
ISO
torcetrapib results in increased expression of NPEPPS mRNA
CTD
PMID:23228038
NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]
CTD
PMID:25617244
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]
CTD
PMID:25617244
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
torcetrapib results in increased expression of NR4A1 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
increases expression
ISO
torcetrapib results in increased expression of NR4A2 mRNA
CTD
PMID:19164467 PMID:23228038 PMID:25617244
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
ISO
torcetrapib results in increased expression of NR4A3 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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Nup62cl
nucleoporin 62 C-terminal like
increases expression
ISO
torcetrapib results in increased expression of NUP62CL mRNA
CTD
PMID:23228038
NCBI chr X:103,668,458...103,724,957
Ensembl chr X:103,668,455...103,724,081
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Odf2l
outer dense fiber of sperm tails 2-like
increases expression
ISO
torcetrapib results in increased expression of ODF2L mRNA
CTD
PMID:23228038
NCBI chr 2:234,036,049...234,072,751
Ensembl chr 2:234,033,652...234,072,747
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Ogfrl1
opioid growth factor receptor-like 1
increases expression
ISO
torcetrapib results in increased expression of OGFRL1 mRNA
CTD
PMID:23228038
NCBI chr 9:25,828,865...25,842,424
Ensembl chr 9:25,828,869...25,842,352
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Ormdl3
ORMDL sphingolipid biosynthesis regulator 3
increases expression
ISO
torcetrapib results in increased expression of ORMDL3 mRNA
CTD
PMID:23228038
NCBI chr10:83,590,052...83,596,035
Ensembl chr10:83,590,071...83,598,620
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Otud4
OTU deubiquitinase 4
increases expression
ISO
torcetrapib results in increased expression of OTUD4 mRNA
CTD
PMID:23228038
NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815
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Palld
palladin, cytoskeletal associated protein
increases expression
ISO
torcetrapib results in increased expression of PALLD mRNA
CTD
PMID:23228038
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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Papolg
poly(A) polymerase gamma
increases expression
ISO
torcetrapib results in increased expression of PAPOLG mRNA
CTD
PMID:23228038
NCBI chr14:97,827,712...97,861,024
Ensembl chr14:97,827,712...97,861,024
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Paqr9
progestin and adipoQ receptor family member 9
increases expression
ISO
torcetrapib results in increased expression of PAQR9 mRNA
CTD
PMID:23228038
NCBI chr 8:96,114,249...96,116,546
G
Patl1
PAT1 homolog 1, processing body mRNA decay factor
increases expression
ISO
torcetrapib results in increased expression of PATL1 mRNA
CTD
PMID:23228038
NCBI chr 1:208,831,115...208,862,904
Ensembl chr 1:208,831,115...208,862,857
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Pcm1
pericentriolar material 1
increases expression
ISO
torcetrapib results in increased expression of PCM1 mRNA
CTD
PMID:23228038
NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
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Pcyt1a
phosphate cytidylyltransferase 1A, choline
increases expression
ISO
torcetrapib results in increased expression of PCYT1A mRNA
CTD
PMID:23228038
NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
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Pde4b
phosphodiesterase 4B
increases expression
ISO
torcetrapib results in increased expression of PDE4B mRNA
CTD
PMID:23228038
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Pde4d
phosphodiesterase 4D
increases expression
ISO
torcetrapib results in increased expression of PDE4D mRNA
CTD
PMID:23228038
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
torcetrapib results in increased expression of PDK4 mRNA
CTD
PMID:23228038
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Pdlim5
PDZ and LIM domain 5
increases expression
ISO
torcetrapib results in increased expression of PDLIM5 mRNA
CTD
PMID:23228038
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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Pdp1
pyruvate dehydrogenase phosphatase catalytic subunit 1
increases expression
ISO
torcetrapib results in increased expression of PDP1 mRNA
CTD
PMID:23228038
NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217
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Per2
period circadian regulator 2
increases expression
ISO
torcetrapib results in increased expression of PER2 mRNA
CTD
PMID:23228038
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Pgm2l1
phosphoglucomutase 2-like 1
increases expression
ISO
torcetrapib results in increased expression of PGM2L1 mRNA
CTD
PMID:23228038
NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902
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Phactr2
phosphatase and actin regulator 2
increases expression
ISO
torcetrapib results in increased expression of PHACTR2 mRNA
CTD
PMID:23228038
NCBI chr 1:7,591,254...7,860,431
Ensembl chr 1:7,597,927...7,860,289
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Phc3
polyhomeotic homolog 3
increases expression
ISO
torcetrapib results in increased expression of PHC3 mRNA
CTD
PMID:23228038
NCBI chr 2:112,408,709...112,483,719
Ensembl chr 2:112,408,531...112,476,540
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Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
increases expression
ISO
torcetrapib results in increased expression of PIP4K2B mRNA
CTD
PMID:23228038
NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938
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Pld6
phospholipase D family, member 6
increases expression
ISO
torcetrapib results in increased expression of PLD6 mRNA
CTD
PMID:23228038
NCBI chr10:44,578,536...44,581,187
Ensembl chr10:44,577,675...44,581,077
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Plekha2
pleckstrin homology domain containing A2
increases expression
ISO
torcetrapib results in increased expression of PLEKHA2 mRNA
CTD
PMID:23228038
NCBI chr16:66,938,684...67,000,661
Ensembl chr16:66,939,109...66,999,395
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Plk2
polo-like kinase 2
increases expression
ISO
torcetrapib results in increased expression of PLK2 mRNA
CTD
PMID:23228038
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
torcetrapib results in increased expression of PMAIP1 mRNA
CTD
PMID:23228038
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Poc1b
POC1 centriolar protein B
increases expression
ISO
torcetrapib results in increased expression of POC1B mRNA
CTD
PMID:23228038
NCBI chr 7:33,924,112...34,025,908
Ensembl chr 7:33,924,189...34,025,903
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of PPARG mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of PPARG mRNA]
CTD
PMID:25617244
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppfibp1
PPFIA binding protein 1
increases expression
ISO
torcetrapib results in increased expression of PPFIBP1 mRNA
CTD
PMID:23228038
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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Ppia
peptidylprolyl isomerase A
increases expression
ISO
torcetrapib results in increased expression of PPIA mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Prelid3b
PRELI domain containing 3B
increases expression
ISO
torcetrapib results in increased expression of PRELID3B mRNA
CTD
PMID:23228038
NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181
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Prickle1
prickle planar cell polarity protein 1
increases expression
ISO
torcetrapib results in increased expression of PRICKLE1 mRNA
CTD
PMID:23228038
NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
increases expression
ISO
torcetrapib results in increased expression of PRKACB mRNA
CTD
PMID:23228038
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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Prrc2c
proline-rich coiled-coil 2C
increases expression
ISO
torcetrapib results in increased expression of PRRC2C mRNA
CTD
PMID:23228038
NCBI chr13:75,003,995...75,073,701
Ensembl chr13:75,004,010...75,073,643
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Psmd7
proteasome 26S subunit, non-ATPase 7
increases expression
ISO
torcetrapib results in increased expression of PSMD7 mRNA
CTD
PMID:23228038
NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
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Ptar1
protein prenyltransferase alpha subunit repeat containing 1
increases expression
ISO
torcetrapib results in increased expression of PTAR1 mRNA
CTD
PMID:23228038
NCBI chr 1:221,283,306...221,326,861
Ensembl chr 1:221,283,415...221,327,073
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Ptp4a1
protein tyrosine phosphatase 4A1
increases expression
ISO
torcetrapib results in increased expression of PTP4A1 mRNA
CTD
PMID:23228038
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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Ptpn14
protein tyrosine phosphatase, non-receptor type 14
increases expression
ISO
torcetrapib results in increased expression of PTPN14 mRNA
CTD
PMID:23228038
NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
increases expression
ISO
torcetrapib results in increased expression of PTPN2 mRNA
CTD
PMID:23228038
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
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Purb
purine rich element binding protein B
increases expression
ISO
torcetrapib results in increased expression of PURB mRNA
CTD
PMID:23228038
NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432
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Pvr
PVR cell adhesion molecule
increases expression
ISO
torcetrapib results in increased expression of PVR mRNA
CTD
PMID:23228038
NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
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Pygo1
pygopus family PHD finger 1
increases expression
ISO
torcetrapib results in increased expression of PYGO1 mRNA
CTD
PMID:23228038
NCBI chr 8:73,666,210...73,684,873
Ensembl chr 8:73,665,593...73,684,869
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Rab3b
RAB3B, member RAS oncogene family
increases expression
ISO
torcetrapib results in increased expression of RAB3B mRNA
CTD
PMID:23228038
NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
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Rab5c
RAB5C, member RAS oncogene family
increases expression
ISO
torcetrapib results in increased expression of RAB5C mRNA
CTD
PMID:23228038
NCBI chr10:85,642,553...85,666,142
Ensembl chr10:85,642,809...85,666,103
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Rad21
RAD21 cohesin complex component
increases expression
ISO
torcetrapib results in increased expression of RAD21 mRNA
CTD
PMID:23228038
NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
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Rarres2
retinoic acid receptor responder 2
multiple interactions increases expression
ISO
NSC 74859 inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]
CTD
PMID:25617244
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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Rbbp6
RB binding protein 6, ubiquitin ligase
increases expression
ISO
torcetrapib results in increased expression of RBBP6 mRNA
CTD
PMID:23228038
NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
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Rbbp9
RB binding protein 9, serine hydrolase
increases expression
ISO
torcetrapib results in increased expression of RBBP9 mRNA
CTD
PMID:23228038
NCBI chr 3:131,925,095...131,939,042
Ensembl chr 3:131,925,341...131,932,156
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Rbfox2
RNA binding fox-1 homolog 2
increases expression
ISO
torcetrapib results in increased expression of RBFOX2 mRNA
CTD
PMID:23228038
NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691
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Rbm39
RNA binding motif protein 39
increases expression
ISO
torcetrapib results in increased expression of RBM39 mRNA
CTD
PMID:23228038
NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
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Rel
REL proto-oncogene, NF-kB subunit
increases expression
ISO
torcetrapib results in increased expression of REL mRNA
CTD
PMID:23228038
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rgs2
regulator of G-protein signaling 2
increases expression
ISO
torcetrapib results in increased expression of RGS2 mRNA
CTD
PMID:23228038
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rhob
ras homolog family member B
increases expression
ISO
torcetrapib results in increased expression of RHOB mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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Rif1
replication timing regulatory factor 1
increases expression
ISO
torcetrapib results in increased expression of RIF1 mRNA
CTD
PMID:23228038
NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
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Rnf13
ring finger protein 13
increases expression
ISO
torcetrapib results in increased expression of RNF13 mRNA
CTD
PMID:23228038
NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801
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Rnf152
ring finger protein 152
increases expression
ISO
torcetrapib results in increased expression of RNF152 mRNA
CTD
PMID:23228038
NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113
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Rnf19a
ring finger protein 19A, RBR E3 ubiquitin protein ligase
increases expression
ISO
torcetrapib results in increased expression of RNF19A mRNA
CTD
PMID:23228038
NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222
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Rsl24d1
ribosomal L24 domain containing 1
increases expression
ISO
torcetrapib results in increased expression of RSL24D1 mRNA
CTD
PMID:23228038
NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001
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Rsrc1
arginine and serine rich coiled-coil 1
increases expression
ISO
torcetrapib results in increased expression of RSRC1 mRNA
CTD
PMID:23228038
NCBI chr 2:151,226,821...151,632,771
Ensembl chr 2:151,231,156...151,632,765
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Rundc1
RUN domain containing 1
increases expression
ISO
torcetrapib results in increased expression of RUNDC1 mRNA
CTD
PMID:23228038
NCBI chr10:86,361,635...86,375,446
Ensembl chr10:86,361,051...86,370,878
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S1pr3
sphingosine-1-phosphate receptor 3
increases expression
ISO
torcetrapib results in increased expression of S1PR3 mRNA
CTD
PMID:23228038
NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
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Samd8
sterile alpha motif domain containing 8
increases expression
ISO
torcetrapib results in increased expression of SAMD8 mRNA
CTD
PMID:23228038
NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379 Ensembl chr15:2,512,105...2,515,379
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Sart3
spliceosome associated factor 3, U4/U6 recycling protein
increases expression
ISO
torcetrapib results in increased expression of SART3 mRNA
CTD
PMID:23228038
NCBI chr12:42,859,026...42,887,041
Ensembl chr12:42,859,305...42,887,038
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Sav1
salvador family WW domain containing protein 1
increases expression
ISO
torcetrapib results in increased expression of SAV1 mRNA
CTD
PMID:23228038
NCBI chr 6:88,478,536...88,500,121
Ensembl chr 6:88,478,539...88,499,968
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Scaf11
SR-related CTD-associated factor 11
increases expression
ISO
torcetrapib results in increased expression of SCAF11 mRNA
CTD
PMID:23228038
NCBI chr 7:127,571,678...127,624,089
Ensembl chr 7:127,574,463...127,624,101
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Scai
suppressor of cancer cell invasion
increases expression
ISO
torcetrapib results in increased expression of SCAI mRNA
CTD
PMID:23228038
NCBI chr 3:22,813,283...22,925,337
Ensembl chr 3:22,819,574...22,925,363
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Sel1l
SEL1L adaptor subunit of SYVN1 ubiquitin ligase
increases expression
ISO
torcetrapib results in increased expression of SEL1L mRNA
CTD
PMID:23228038
NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
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Septin11
septin 11
increases expression
ISO
torcetrapib results in increased expression of SEPTIN11 mRNA
CTD
PMID:23228038
NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853
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Setx
senataxin
increases expression
ISO
torcetrapib results in increased expression of SETX mRNA
CTD
PMID:23228038
NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
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Sgcb
sarcoglycan, beta
increases expression
ISO
torcetrapib results in increased expression of SGCB mRNA
CTD
PMID:23228038
NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
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Sik1
salt-inducible kinase 1
increases expression
ISO
torcetrapib results in increased expression of SIK1 mRNA
CTD
PMID:23228038
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Sike1
suppressor of IKBKE 1
increases expression
ISO
torcetrapib results in increased expression of SIKE1 mRNA
CTD
PMID:23228038
NCBI chr 2:190,518,002...190,525,833
Ensembl chr 2:190,518,002...190,525,832
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Sinhcaf
SIN3-HDAC complex associated factor
increases expression
ISO
torcetrapib results in increased expression of SINHCAF mRNA
CTD
PMID:23228038
NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276
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Slain2
SLAIN motif family, member 2
increases expression
ISO
torcetrapib results in increased expression of SLAIN2 mRNA
CTD
PMID:23228038
NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678
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Slc25a13
solute carrier family 25 member 13
increases expression
ISO
torcetrapib results in increased expression of SLC25A13 mRNA
CTD
PMID:23228038
NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
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Slc2a3
solute carrier family 2 member 3
increases expression
ISO
torcetrapib results in increased expression of SLC2A3 mRNA
CTD
PMID:23228038
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc30a4
solute carrier family 30 member 4
increases expression
ISO
torcetrapib results in increased expression of SLC30A4 mRNA
CTD
PMID:23228038
NCBI chr 3:109,753,270...109,775,306
Ensembl chr 3:109,753,273...109,775,306
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Slc39a6
solute carrier family 39 member 6
increases expression
ISO
torcetrapib results in increased expression of SLC39A6 mRNA
CTD
PMID:23228038
NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417
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Smarcc1
SWI/SNF related BAF chromatin remodeling complex subunit C1
increases expression
ISO
torcetrapib results in increased expression of SMARCC1 mRNA
CTD
PMID:23228038
NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720
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Smc1a
structural maintenance of chromosomes 1A
increases expression
ISO
torcetrapib results in increased expression of SMC1A mRNA
CTD
PMID:23228038
NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056
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Smc3
structural maintenance of chromosomes 3
increases expression
ISO
torcetrapib results in increased expression of SMC3 mRNA
CTD
PMID:23228038
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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Snapc1
small nuclear RNA activating complex, polypeptide 1
increases expression
ISO
torcetrapib results in increased expression of SNAPC1 mRNA
CTD
PMID:23228038
NCBI chr 6:92,684,785...92,710,772
Ensembl chr 6:92,684,752...92,707,746
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Snx13
sorting nexin 13
increases expression
ISO
torcetrapib results in increased expression of SNX13 mRNA
CTD
PMID:23228038
NCBI chr 6:51,758,258...51,862,260
Ensembl chr 6:51,753,036...51,860,224
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Socs1
suppressor of cytokine signaling 1
increases expression
ISO
torcetrapib results in increased expression of SOCS1 mRNA
CTD
PMID:23228038
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
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Spred1
sprouty-related, EVH1 domain containing 1
increases expression
ISO
torcetrapib results in increased expression of SPRED1 mRNA
CTD
PMID:23228038
NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718
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Spry2
sprouty RTK signaling antagonist 2
increases expression
ISO
torcetrapib results in increased expression of SPRY2 mRNA
CTD
PMID:23228038
NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009
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Srek1
splicing regulatory glutamic acid and lysine rich protein 1
increases expression
ISO
torcetrapib results in increased expression of SREK1 mRNA
CTD
PMID:23228038
NCBI chr 2:34,849,548...34,885,120
Ensembl chr 2:34,852,458...34,884,972
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Ssr3
signal sequence receptor subunit 3
increases expression
ISO
torcetrapib results in increased expression of SSR3 mRNA
CTD
PMID:23228038
NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132
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Star
steroidogenic acute regulatory protein
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; NSC 74859 inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of STAR mRNA] torcetrapib results in increased expression of STAR mRNA; torcetrapib results in increased expression of STAR protein
CTD
PMID:25617244 PMID:28235592
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat3
signal transducer and activator of transcription 3
increases phosphorylation
ISO
torcetrapib results in increased phosphorylation of STAT3 protein
CTD
PMID:25617244
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stk4
serine/threonine kinase 4
increases expression
ISO
torcetrapib results in increased expression of STK4 mRNA
CTD
PMID:23228038
NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
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Ston2
stonin 2
increases expression
ISO
torcetrapib results in increased expression of STON2 mRNA
CTD
PMID:23228038
NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376
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Sts
steroid sulfatase
increases expression
ISO
torcetrapib results in increased expression of STS mRNA
CTD
PMID:23228038
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Svip
small VCP interacting protein
increases expression
ISO
torcetrapib results in increased expression of SVIP mRNA
CTD
PMID:23228038
NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116
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Szrd1
SUZ RNA binding domain containing 1
increases expression
ISO
torcetrapib results in increased expression of SZRD1 mRNA
CTD
PMID:23228038
NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252
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Tacc1
transforming, acidic coiled-coil containing protein 1
increases expression
ISO
torcetrapib results in increased expression of TACC1 mRNA
CTD
PMID:23228038
NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733
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Tasp1
taspase 1
increases expression
ISO
torcetrapib results in increased expression of TASP1 mRNA
CTD
PMID:23228038
NCBI chr 3:127,176,416...127,408,039
Ensembl chr 3:127,176,692...127,399,600
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Tbl1xr1
TBL1X/Y related 1
increases expression
ISO
torcetrapib results in increased expression of TBL1XR1 mRNA
CTD
PMID:23228038
NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055
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Tcaf1
TRPM8 channel-associated factor 1
increases expression
ISO
torcetrapib results in increased expression of TCAF1 mRNA
CTD
PMID:23228038
NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309
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Tcf4
transcription factor 4
increases expression
ISO
torcetrapib results in increased expression of TCF4 mRNA
CTD
PMID:23228038
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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Tent5a
terminal nucleotidyltransferase 5A
increases expression
ISO
torcetrapib results in increased expression of TENT5A mRNA
CTD
PMID:23228038
NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045
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Tfrc
transferrin receptor
increases expression
ISO
torcetrapib results in increased expression of TFRC mRNA
CTD
PMID:23228038
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb2
transforming growth factor, beta 2
increases expression
ISO
torcetrapib results in increased expression of TGFB2 mRNA
CTD
PMID:23228038
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tgfbr2
transforming growth factor, beta receptor 2
increases expression
ISO
torcetrapib results in increased expression of TGFBR2 mRNA
CTD
PMID:23228038
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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Tgoln2
trans-golgi network protein 2
increases expression
ISO
torcetrapib results in increased expression of TGOLN2 mRNA
CTD
PMID:23228038
NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
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Thumpd3
THUMP domain containing 3
increases expression
ISO
torcetrapib results in increased expression of THUMPD3 mRNA
CTD
PMID:23228038
NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
torcetrapib results in increased expression of TIPARP mRNA
CTD
PMID:23228038
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tle4
TLE family member 4, transcriptional corepressor
increases expression
ISO
torcetrapib results in increased expression of TLE4 mRNA
CTD
PMID:23228038
NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862
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Tmem165
transmembrane protein 165
increases expression
ISO
torcetrapib results in increased expression of TMEM165 mRNA
CTD
PMID:23228038
NCBI chr14:31,993,489...32,018,717
Ensembl chr14:31,993,493...32,018,717
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Tnfrsf12a
TNF receptor superfamily member 12A
increases expression
ISO
torcetrapib results in increased expression of TNFRSF12A mRNA
CTD
PMID:23228038
NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
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Tnpo2
transportin 2
increases expression
ISO
torcetrapib results in increased expression of TNPO2 mRNA
CTD
PMID:23228038
NCBI chr19:23,099,398...23,119,696
Ensembl chr19:23,099,401...23,119,596
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Tob1
transducer of ErbB-2.1
increases expression
ISO
torcetrapib results in increased expression of TOB1 mRNA
CTD
PMID:23228038
NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
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Top3a
DNA topoisomerase III alpha
increases expression
ISO
torcetrapib results in increased expression of TOP3A mRNA
CTD
PMID:23228038
NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559
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Tp53bp1
tumor protein p53 binding protein 1
increases expression
ISO
torcetrapib results in increased expression of TP53BP1 mRNA
CTD
PMID:23228038
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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Tpm4
tropomyosin 4
increases expression
ISO
torcetrapib results in increased expression of TPM4 mRNA
CTD
PMID:23228038
NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
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Tpp2
tripeptidyl peptidase 2
increases expression
ISO
torcetrapib results in increased expression of TPP2 mRNA
CTD
PMID:23228038
NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
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Tpr
translocated promoter region, nuclear basket protein
increases expression
ISO
torcetrapib results in increased expression of TPR mRNA
CTD
PMID:23228038
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Trib1
tribbles pseudokinase 1
increases expression
ISO
torcetrapib results in increased expression of TRIB1 mRNA
CTD
PMID:23228038
NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
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Trim2
tripartite motif-containing 2
increases expression
ISO
torcetrapib results in increased expression of TRIM2 mRNA
CTD
PMID:23228038
NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
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Trim23
tripartite motif-containing 23
increases expression
ISO
torcetrapib results in increased expression of TRIM23 mRNA
CTD
PMID:23228038
NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743
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Ttc3
tetratricopeptide repeat domain 3
increases expression
ISO
torcetrapib results in increased expression of TTC3 mRNA
CTD
PMID:23228038
NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975
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Tut7
terminal uridylyl transferase 7
increases expression
ISO
torcetrapib results in increased expression of TUT7 mRNA
CTD
PMID:23228038
NCBI chr17:4,849,287...4,903,542
Ensembl chr17:4,849,283...4,903,169
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Twf1
twinfilin actin-binding protein 1
increases expression
ISO
torcetrapib results in increased expression of TWF1 mRNA
CTD
PMID:23228038
NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894
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Uba6
ubiquitin-like modifier activating enzyme 6
increases expression
ISO
torcetrapib results in increased expression of UBA6 mRNA
CTD
PMID:23228038
NCBI chr14:21,884,039...21,947,857
Ensembl chr14:21,884,039...21,947,857
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Ube2w
ubiquitin-conjugating enzyme E2W
increases expression
ISO
torcetrapib results in increased expression of UBE2W mRNA
CTD
PMID:23228038
NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965
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Ubxn4
UBX domain protein 4
increases expression
ISO
torcetrapib results in increased expression of UBXN4 mRNA
CTD
PMID:23228038
NCBI chr13:39,740,064...39,772,493
Ensembl chr13:39,740,107...39,772,491
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Uevld
UEV and lactate/malate dehyrogenase domains
increases expression
ISO
torcetrapib results in increased expression of UEVLD mRNA
CTD
PMID:23228038
NCBI chr 1:97,454,188...97,486,004
Ensembl chr 1:97,453,946...97,486,000
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Upf1
UPF1, RNA helicase and ATPase
increases expression
ISO
torcetrapib results in increased expression of UPF1 mRNA
CTD
PMID:23228038
NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
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Usp4
ubiquitin specific peptidase 4
increases expression
ISO
torcetrapib results in increased expression of USP4 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 8:109,035,402...109,079,382
Ensembl chr 8:109,036,099...109,080,427
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Usp42
ubiquitin specific peptidase 42
increases expression
ISO
torcetrapib results in increased expression of USP42 mRNA
CTD
PMID:23228038
NCBI chr12:10,800,864...10,840,785
Ensembl chr12:10,802,581...10,840,785
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Usp49
ubiquitin specific peptidase 49
increases expression
ISO
torcetrapib results in increased expression of USP49 mRNA
CTD
PMID:23228038
NCBI chr 9:13,305,640...13,366,132
Ensembl chr 9:13,308,178...13,366,132
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Vps13c
vacuolar protein sorting 13 homolog C
increases expression
ISO
torcetrapib results in increased expression of VPS13C mRNA
CTD
PMID:23228038
NCBI chr 8:68,478,366...68,651,893
Ensembl chr 8:68,478,395...68,651,895
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Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
increases expression
ISO
torcetrapib results in increased expression of WARS2 mRNA
CTD
PMID:23228038
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
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Wsb1
WD repeat and SOCS box-containing 1
increases expression
ISO
torcetrapib results in increased expression of WSB1 mRNA
CTD
PMID:23228038
NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
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Zbtb21
zinc finger and BTB domain containing 21
increases expression
ISO
torcetrapib results in increased expression of ZBTB21 mRNA
CTD
PMID:23228038
NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996
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Zc3h7a
zinc finger CCCH type containing 7 A
increases expression
ISO
torcetrapib results in increased expression of ZC3H7A mRNA
CTD
PMID:23228038
NCBI chr10:4,473,177...4,512,668
Ensembl chr10:4,473,203...4,512,665
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Zfp277
zinc finger protein 277
increases expression
ISO
torcetrapib results in increased expression of ZNF277 mRNA
CTD
PMID:23228038
NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765
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Zfp36l2
zinc finger protein 36, C3H type-like 2
increases expression
ISO
torcetrapib results in increased expression of ZFP36L2 mRNA
CTD
PMID:23228038
NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064
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Zfp46
zinc finger protein 46
increases expression
ISO
torcetrapib results in increased expression of ZNF436 mRNA
CTD
PMID:23228038
NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459
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Zfp641
zinc finger protein 641
increases expression
ISO
torcetrapib results in increased expression of ZNF641 mRNA
CTD
PMID:23228038
NCBI chr 7:129,434,576...129,444,847
Ensembl chr 7:129,434,576...129,444,644
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Zfp655
zinc finger protein 655
increases expression
ISO
torcetrapib results in increased expression of ZNF655 mRNA
CTD
PMID:23228038
NCBI chr12:9,349,985...9,375,449
Ensembl chr12:9,357,639...9,374,569
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Zfp704
zinc finger protein 704
increases expression
ISO
torcetrapib results in increased expression of ZNF704 mRNA
CTD
PMID:23228038
NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282
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Zfp800
zinc finger protein 800
increases expression
ISO
torcetrapib results in increased expression of ZNF800 mRNA
CTD
PMID:23228038
NCBI chr 4:56,798,326...56,849,766
Ensembl chr 4:56,826,997...56,849,791
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Zfr
zinc finger RNA binding protein
increases expression
ISO
torcetrapib results in increased expression of ZFR mRNA
CTD
PMID:23228038
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
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Znf740
zinc finger protein 740
increases expression
ISO
torcetrapib results in increased expression of ZNF740 mRNA
CTD
PMID:23228038
NCBI chr 7:133,337,038...133,347,594
Ensembl chr 7:133,336,671...133,347,589
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