CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: torcetrapib
Accession: CHEBI:49203
browse the term
Definition: A carbamate ester that has formula C26H25F9N2O4.
Synonyms: exact_synonym: ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
related_synonym: (2R,4S)-4-((3,5-bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester; Formula=C26H25F9N2O4; InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1; InChIKey=CMSGWTNRGKRWGS-NQIIRXRSSA-N; SMILES=CCOC(=O)N1[C@H](CC)C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c2cc(ccc12)C(F)(F)F
xref: CAS:262352-17-0; KEGG:D06195
xref_mesh: MESH:C483909
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Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
increases expression
ISO
torcetrapib results in increased expression of AASDHPPT mRNA
CTD
PMID:23228038
NCBI chr 8:1,453,226...1,463,990
Ensembl chr 8:1,452,282...1,463,966
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Aff2
ALF transcription elongation factor 2
increases expression
ISO
torcetrapib results in increased expression of AFF2 mRNA
CTD
PMID:23228038
NCBI chr X:147,928,130...148,432,484
Ensembl chr X:147,928,407...148,429,995
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Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
increases expression
ISO
torcetrapib results in increased expression of AGPAT3 mRNA
CTD
PMID:23228038
NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358
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Ahctf1
AT hook containing transcription factor 1
increases expression
ISO
torcetrapib results in increased expression of AHCTF1 mRNA
CTD
PMID:23228038
NCBI chr13:91,481,936...91,536,391
Ensembl chr13:91,481,936...91,536,391
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Akirin1
akirin 1
increases expression
ISO
torcetrapib results in increased expression of AKIRIN1 mRNA
CTD
PMID:23228038
NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762
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Akt2
AKT serine/threonine kinase 2
increases expression
ISO
torcetrapib results in increased expression of AKT2 mRNA
CTD
PMID:23228038
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Akt3
AKT serine/threonine kinase 3
increases expression
ISO
torcetrapib results in increased expression of AKT3 mRNA
CTD
PMID:23228038
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Ammecr1
AMMECR nuclear protein 1
increases expression
ISO
torcetrapib results in increased expression of AMMECR1 mRNA
CTD
PMID:23228038
NCBI chr X:106,465,982...106,571,382
Ensembl chr X:106,466,699...106,571,487
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Amotl1
angiomotin-like 1
increases expression
ISO
torcetrapib results in increased expression of AMOTL1 mRNA
CTD
PMID:23228038
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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Angpt1
angiopoietin 1
increases expression
ISO
torcetrapib results in increased expression of ANGPT1 mRNA
CTD
PMID:23228038
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Ank3
ankyrin 3
increases expression
ISO
torcetrapib results in increased expression of ANK3 mRNA
CTD
PMID:23228038
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Ankrd11
ankyrin repeat domain containing 11
increases expression
ISO
torcetrapib results in increased expression of ANKRD11 mRNA
CTD
PMID:23228038
NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962
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Anxa1
annexin A1
increases expression
ISO
torcetrapib results in increased expression of ANXA1 mRNA
CTD
PMID:23228038
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Ap3d1
adaptor related protein complex 3 subunit delta 1
increases expression
ISO
torcetrapib results in increased expression of AP3D1 mRNA
CTD
PMID:23228038
NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643
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Apbb2
amyloid beta precursor protein binding family B member 2
increases expression
ISO
torcetrapib results in increased expression of APBB2 mRNA
CTD
PMID:23228038
NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495
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Appl1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
increases expression
ISO
torcetrapib results in increased expression of APPL1 mRNA
CTD
PMID:23228038
NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
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Arg2
arginase 2
increases expression
ISO
torcetrapib results in increased expression of ARG2 mRNA
CTD
PMID:23228038
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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Arhgap29
Rho GTPase activating protein 29
increases expression
ISO
torcetrapib results in increased expression of ARHGAP29 mRNA
CTD
PMID:23228038
NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
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Arid4b
AT-rich interaction domain 4B
increases expression
ISO
torcetrapib results in increased expression of ARID4B mRNA
CTD
PMID:23228038
NCBI chr17:51,138,419...51,262,894
Ensembl chr17:51,138,535...51,262,906
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Arl5b
ARF like GTPase 5B
increases expression
ISO
torcetrapib results in increased expression of ARL5B mRNA
CTD
PMID:23228038
NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854
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Atf3
activating transcription factor 3
increases expression
ISO
torcetrapib results in increased expression of ATF3 mRNA
CTD
PMID:23228038
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atg12
autophagy related 12
increases expression
ISO
torcetrapib results in increased expression of ATG12 mRNA
CTD
PMID:23228038
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
increases expression
ISO
torcetrapib results in increased expression of ATP2A2 mRNA
CTD
PMID:23228038
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Atrx
ATRX, chromatin remodeler
increases expression
ISO
torcetrapib results in increased expression of ATRX mRNA
CTD
PMID:23228038
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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Atxn7l3b
ataxin 7-like 3B
increases expression
ISO
torcetrapib results in increased expression of ATXN7L3B mRNA
CTD
PMID:23228038
NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878
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Bdnf
brain-derived neurotrophic factor
increases expression
ISO
torcetrapib results in increased expression of BDNF mRNA
CTD
PMID:23228038
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bicd2
BICD cargo adaptor 2
increases expression
ISO
torcetrapib results in increased expression of BICD2 mRNA
CTD
PMID:23228038
NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889
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Bod1l1
biorientation of chromosomes in cell division 1-like 1
increases expression
ISO
torcetrapib results in increased expression of BOD1L mRNA
CTD
PMID:23228038
NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
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Brcc3
BRCA1/BRCA2-containing complex subunit 3
increases expression
ISO
torcetrapib results in increased expression of BRCC3 mRNA
CTD
PMID:23228038
NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
torcetrapib results in increased expression of BTG2 mRNA
CTD
PMID:23228038
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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C17h5orf24
similar to human chromosome 5 open reading frame 24
increases expression
ISO
torcetrapib results in increased expression of C5ORF24 mRNA
CTD
PMID:23228038
NCBI chr17:8,923,041...8,932,958
Ensembl chr17:8,922,675...8,933,356
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C3h11orf96
similar to human chromosome 11 open reading frame 96
increases expression
ISO
torcetrapib results in increased expression of C11ORF96 mRNA
CTD
PMID:23228038
NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
increases expression
ISO
torcetrapib results in increased expression of CACNA1C mRNA
CTD
PMID:20498617
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacul1
CDK2-associated, cullin domain 1
increases expression
ISO
torcetrapib results in increased expression of CACUL1 mRNA
CTD
PMID:23228038
NCBI chr 1:259,666,335...259,726,249
Ensembl chr 1:259,668,516...259,726,082
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Cald1
caldesmon 1
increases expression
ISO
torcetrapib results in increased expression of CALD1 mRNA
CTD
PMID:23228038
NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
increases expression
ISO
torcetrapib results in increased expression of CAMK2D mRNA
CTD
PMID:23228038
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Cask
calcium/calmodulin dependent serine protein kinase
increases expression
ISO
torcetrapib results in increased expression of CASK mRNA
CTD
PMID:23228038
NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694
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Cbl
Cbl proto-oncogene
increases expression
ISO
torcetrapib results in increased expression of CBL mRNA
CTD
PMID:23228038
NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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Ccdc88a
coiled coil domain containing 88A
increases expression
ISO
torcetrapib results in increased expression of CCDC88A mRNA
CTD
PMID:23228038
NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368
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Ccn1
cellular communication network factor 1
increases expression
ISO
torcetrapib results in increased expression of CCN1 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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Ccsap
centriole, cilia and spindle-associated protein
increases expression
ISO
torcetrapib results in increased expression of CCSAP mRNA
CTD
PMID:23228038
NCBI chr19:51,824,954...51,843,469
Ensembl chr19:51,826,994...51,842,753
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Ccser2
coiled-coil serine-rich protein 2
increases expression
ISO
torcetrapib results in increased expression of CCSER2 mRNA
CTD
PMID:23228038
NCBI chr16:12,613,103...12,725,764
Ensembl chr16:12,613,103...12,725,738
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Cd47
Cd47 molecule
increases expression
ISO
torcetrapib results in increased expression of CD47 mRNA
CTD
PMID:23228038
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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Cd55
CD55 molecule (Cromer blood group)
increases expression
ISO
torcetrapib results in increased expression of CD55 mRNA
CTD
PMID:23228038
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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Cdk14
cyclin-dependent kinase 14
increases expression
ISO
torcetrapib results in increased expression of CDK14 mRNA
CTD
PMID:23228038
NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861
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Cdk6
cyclin-dependent kinase 6
increases expression
ISO
torcetrapib results in increased expression of CDK6 mRNA
CTD
PMID:23228038
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cep89
centrosomal protein 89
increases expression
ISO
torcetrapib results in increased expression of CEP89 mRNA
CTD
PMID:23228038
NCBI chr 1:88,058,211...88,100,114
Ensembl chr 1:88,058,227...88,100,112
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Chd4
chromodomain helicase DNA binding protein 4
increases expression
ISO
torcetrapib results in increased expression of CHD4 mRNA
CTD
PMID:23228038
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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Chd9
chromodomain helicase DNA binding protein 9
increases expression
ISO
torcetrapib results in increased expression of CHD9 mRNA
CTD
PMID:23228038
NCBI chr19:15,941,535...16,146,220
Ensembl chr19:15,942,687...16,164,556
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Chml
CHM like Rab escort protein
increases expression
ISO
torcetrapib results in increased expression of CHML mRNA
CTD
PMID:23228038
NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862
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Cimip2b
ciliary microtubule inner protein 2B
increases expression
ISO
torcetrapib results in increased expression of CIMIP2B mRNA
CTD
PMID:23228038
NCBI chr 5:57,675,537...57,680,133
Ensembl chr 5:57,675,462...57,678,611
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Cln5
CLN5, intracellular trafficking protein
increases expression
ISO
torcetrapib results in increased expression of CLN5 mRNA
CTD
PMID:23228038
NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 Ensembl chr 2:79,893,548...79,903,438
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Cnot6l
CCR4-NOT transcription complex, subunit 6-like
increases expression
ISO
torcetrapib results in increased expression of CNOT6L mRNA
CTD
PMID:23228038
NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203
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Cnst
consortin, connexin sorting protein
increases expression
ISO
torcetrapib results in increased expression of CNST mRNA
CTD
PMID:23228038
NCBI chr13:91,296,740...91,373,531
Ensembl chr13:91,296,142...91,373,531
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Cpeb4
cytoplasmic polyadenylation element binding protein 4
increases expression
ISO
torcetrapib results in increased expression of CPEB4 mRNA
CTD
PMID:23228038
NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603
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Crem
cAMP responsive element modulator
increases expression
ISO
torcetrapib results in increased expression of CREM mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Csnk1g1
casein kinase 1, gamma 1
increases expression
ISO
torcetrapib results in increased expression of CSNK1G1 mRNA
CTD
PMID:23228038
NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826
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Csrnp1
cysteine and serine rich nuclear protein 1
increases expression
ISO
torcetrapib results in increased expression of CSRNP1 mRNA
CTD
PMID:23228038
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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Csrnp3
cysteine and serine rich nuclear protein 3
increases expression
ISO
torcetrapib results in increased expression of CSRNP3 mRNA
CTD
PMID:23228038
NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950
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Cth
cystathionine gamma-lyase
increases expression
ISO
torcetrapib results in increased expression of CTH mRNA
CTD
PMID:23228038
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Cxadr
CXADR, Ig-like cell adhesion molecule
increases expression
ISO
torcetrapib results in increased expression of CXADR mRNA
CTD
PMID:23228038
NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046
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Cybb
cytochrome b-245 beta chain
increases expression
ISO
torcetrapib results in increased expression of CYBB protein
CTD
PMID:25617244
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cycs
cytochrome c, somatic
increases expression
ISO
torcetrapib results in increased expression of CYCS mRNA
CTD
PMID:23228038
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
ISO
torcetrapib results in increased expression of CYP11A1 mRNA
CTD
PMID:28235592
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
increases expression multiple interactions
ISO
torcetrapib results in increased expression of CYP11B1 mRNA Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]
CTD
PMID:19164467 PMID:25617244 PMID:28235592
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; NSC 74859 inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA] torcetrapib results in increased expression of CYP11B2 mRNA; torcetrapib results in increased expression of CYP11B2 protein
CTD
PMID:19164467 PMID:20498617 PMID:25617244 PMID:28235592
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression
ISO
torcetrapib results in increased expression of CYP17A1 mRNA
CTD
PMID:28235592
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyren
cell cycle regulator of NHEJ
increases expression
ISO
torcetrapib results in increased expression of CYREN mRNA
CTD
PMID:23228038
NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602
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Dbt
dihydrolipoamide branched chain transacylase E2
increases expression
ISO
torcetrapib results in increased expression of DBT mRNA
CTD
PMID:23228038
NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
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Dcaf16
DDB1 and CUL4 associated factor 16
increases expression
ISO
torcetrapib results in increased expression of DCAF16 mRNA
CTD
PMID:23228038
NCBI chr14:65,449,631...65,450,015
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Dcaf7
DDB1 and CUL4 associated factor 7
increases expression
ISO
torcetrapib results in increased expression of DCAF7 mRNA
CTD
PMID:23228038
NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275
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Dctn5
dynactin subunit 5
increases expression
ISO
torcetrapib results in increased expression of DCTN5 mRNA
CTD
PMID:23228038
NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
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Dnajb14
DnaJ heat shock protein family (Hsp40) member B14
increases expression
ISO
torcetrapib results in increased expression of DNAJB14 mRNA
CTD
PMID:23228038
NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490
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Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
increases expression
ISO
torcetrapib results in increased expression of DNAJC12 mRNA
CTD
PMID:23228038
NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
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Dnajc13
DnaJ heat shock protein family (Hsp40) member C13
increases expression
ISO
torcetrapib results in increased expression of DNAJC13 mRNA
CTD
PMID:23228038
NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317
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Dst
dystonin
increases expression
ISO
torcetrapib results in increased expression of DST mRNA
CTD
PMID:23228038
NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
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Dusp1
dual specificity phosphatase 1
increases expression
ISO
torcetrapib results in increased expression of DUSP1 mRNA
CTD
PMID:23228038
NCBI chr10:16,680,478...16,683,275
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Dusp16
dual specificity phosphatase 16
increases expression
ISO
torcetrapib results in increased expression of DUSP16 mRNA
CTD
PMID:23228038
NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980
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Dync1h1
dynein cytoplasmic 1 heavy chain 1
increases expression
ISO
torcetrapib results in increased expression of DYNC1H1 mRNA
CTD
PMID:23228038
NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
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Ece1
endothelin converting enzyme 1
increases expression
ISO
torcetrapib results in increased expression of ECE1 mRNA
CTD
PMID:23228038
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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Edn1
endothelin 1
multiple interactions
EXP
torcetrapib affects the expression of and affects the activity of EDN1 protein
CTD
PMID:21920972
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Edrf1
erythroid differentiation regulatory factor 1
increases expression
ISO
torcetrapib results in increased expression of EDRF1 mRNA
CTD
PMID:23228038
NCBI chr 1:188,441,514...188,478,743
Ensembl chr 1:188,441,634...188,478,701
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Egln1
egl-9 family hypoxia-inducible factor 1
increases expression
ISO
torcetrapib results in increased expression of EGLN1 mRNA
CTD
PMID:23228038
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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Ehbp1
EH domain binding protein 1
increases expression
ISO
torcetrapib results in increased expression of EHBP1 mRNA
CTD
PMID:23228038
NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
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Eid1
EP300 interacting inhibitor of differentiation 1
increases expression
ISO
torcetrapib results in increased expression of EID1 mRNA
CTD
PMID:23228038
NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752
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Eif4g1
eukaryotic translation initiation factor 4 gamma 1
increases expression
ISO
torcetrapib results in increased expression of EIF4G1 mRNA
CTD
PMID:23228038
NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
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Elf1
E74 like ETS transcription factor 1
increases expression
ISO
torcetrapib results in increased expression of ELF1 mRNA
CTD
PMID:23228038
NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
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Ep400
E1A binding protein p400
increases expression
ISO
torcetrapib results in increased expression of EP400 mRNA
CTD
PMID:23228038
NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
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Eppk1
epiplakin 1
increases expression
ISO
torcetrapib results in increased expression of EPPK1 mRNA
CTD
PMID:23228038
NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159
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Erc1
ELKS/RAB6-interacting/CAST family member 1
increases expression
ISO
torcetrapib results in increased expression of ERC1 mRNA
CTD
PMID:23228038
NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639
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Exd2
exonuclease 3'-5' domain containing 2
increases expression
ISO
torcetrapib results in increased expression of EXD2 mRNA
CTD
PMID:23228038
NCBI chr 6:100,116,867...100,150,452
Ensembl chr 6:100,116,867...100,150,442
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Exosc6
exosome component 6
increases expression
ISO
torcetrapib results in increased expression of EXOSC6 mRNA
CTD
PMID:23228038
NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515
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Fam114a1
family with sequence similarity 114, member A1
increases expression
ISO
torcetrapib results in increased expression of FAM114A1 mRNA
CTD
PMID:23228038
NCBI chr14:43,275,693...43,346,154
Ensembl chr14:43,275,701...43,346,174
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Fancm
FA complementation group M
increases expression
ISO
torcetrapib results in increased expression of FANCM mRNA
CTD
PMID:23228038
NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028
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Fbxl4
F-box and leucine-rich repeat protein 4
increases expression
ISO
torcetrapib results in increased expression of FBXL4 mRNA
CTD
PMID:23228038
NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443
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Fbxo28
F-box protein 28
increases expression
ISO
torcetrapib results in increased expression of FBXO28 mRNA
CTD
PMID:23228038
NCBI chr13:93,995,993...94,021,464
Ensembl chr13:93,995,996...94,021,464
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Fgf9
fibroblast growth factor 9
increases expression
ISO
torcetrapib results in increased expression of FGF9 mRNA
CTD
PMID:23228038
NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
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Fkbp10
FKBP prolyl isomerase 10
increases expression
ISO
torcetrapib results in increased expression of FKBP10 mRNA
CTD
PMID:23228038
NCBI chr10:85,345,434...85,357,998
Ensembl chr10:85,346,126...85,427,330
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Flrt2
fibronectin leucine rich transmembrane protein 2
increases expression
ISO
torcetrapib results in increased expression of FLRT2 mRNA
CTD
PMID:23228038
NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of FOS mRNA
CTD
PMID:23228038
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosl2
FOS like 2, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of FOSL2 mRNA
CTD
PMID:23228038
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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Fsd1l
fibronectin type III and SPRY domain containing 1-like
increases expression
ISO
torcetrapib results in increased expression of FSD1L mRNA
CTD
PMID:23228038
NCBI chr 5:68,258,877...68,334,931
Ensembl chr 5:68,258,932...68,334,928
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Fzd10
frizzled class receptor 10
increases expression
ISO
torcetrapib results in increased expression of FZD10 mRNA
CTD
PMID:23228038
NCBI chr12:28,098,371...28,101,566
Ensembl chr12:28,098,371...28,101,566
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
torcetrapib results in increased expression of GADD45A mRNA
CTD
PMID:23228038
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gem
GTP binding protein overexpressed in skeletal muscle
increases expression
ISO
torcetrapib results in increased expression of GEM mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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Git2
GIT ArfGAP 2
increases expression
ISO
torcetrapib results in increased expression of GIT2 mRNA
CTD
PMID:23228038
NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
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Glipr1
GLI pathogenesis-related 1
increases expression
ISO
torcetrapib results in increased expression of GLIPR1 mRNA
CTD
PMID:23228038
NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429
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Gng12
G protein subunit gamma 12
increases expression
ISO
torcetrapib results in increased expression of GNG12 mRNA
CTD
PMID:23228038
NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
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Golga2
golgin A2
increases expression
ISO
torcetrapib results in increased expression of GOLGA2 mRNA
CTD
PMID:23228038
NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
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Golim4
golgi integral membrane protein 4
increases expression
ISO
torcetrapib results in increased expression of GOLIM4 mRNA
CTD
PMID:23228038
NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253
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H4f3
H1.3 linker histone, cluster member
increases expression
ISO
torcetrapib results in increased expression of H1-3 mRNA
CTD
PMID:23228038
NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334
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Hacd2
3-hydroxyacyl-CoA dehydratase 2
increases expression
ISO
torcetrapib results in increased expression of HACD2 mRNA
CTD
PMID:23228038
NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889
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Hapstr1
HUWE1 associated protein modifying stress responses
increases expression
ISO
torcetrapib results in increased expression of HAPSTR1 mRNA
CTD
PMID:23228038
NCBI chr10:6,746,037...6,774,992
Ensembl chr10:6,746,048...6,774,992
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Haus2
HAUS augmin like complex subunit 2
increases expression
ISO
torcetrapib results in increased expression of HAUS2 mRNA
CTD
PMID:23228038
NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157
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Heatr1
HEAT repeat containing 1
increases expression
ISO
torcetrapib results in increased expression of HEATR1 mRNA
CTD
PMID:23228038
NCBI chr17:58,053,288...58,093,895
Ensembl chr17:58,051,700...58,093,948
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Hectd1
HECT domain E3 ubiquitin protein ligase 1
increases expression
ISO
torcetrapib results in increased expression of HECTD1 mRNA
CTD
PMID:23228038
NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053
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Hfe
homeostatic iron regulator
increases expression
ISO
torcetrapib results in increased expression of HFE mRNA
CTD
PMID:23228038
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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Hipk2
homeodomain interacting protein kinase 2
increases expression
ISO
torcetrapib results in increased expression of HIPK2 mRNA
CTD
PMID:23228038
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
increases expression
ISO
torcetrapib results in increased expression of HSD3B2 mRNA
CTD
PMID:28235592
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
torcetrapib results in increased expression of HSPH1 mRNA
CTD
PMID:23228038
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Htatsf1
HIV-1 Tat specific factor 1
increases expression
ISO
torcetrapib results in increased expression of HTATSF1 mRNA
CTD
PMID:23228038
NCBI chr X:134,935,426...134,949,607
Ensembl chr X:134,935,426...134,949,607
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Id4
inhibitor of DNA binding 4
increases expression
ISO
torcetrapib results in increased expression of ID4 mRNA
CTD
PMID:23228038
NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
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Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
increases expression
ISO
torcetrapib results in increased expression of IGF2BP3 mRNA
CTD
PMID:23228038
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
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Il13ra1
interleukin 13 receptor subunit alpha 1
increases expression
ISO
torcetrapib results in increased expression of IL13RA1 mRNA
CTD
PMID:23228038
NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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Il6st
interleukin 6 cytokine family signal transducer
increases expression
ISO
torcetrapib results in increased expression of IL6ST mRNA
CTD
PMID:23228038
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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Ilf3
interleukin enhancer binding factor 3
increases expression
ISO
torcetrapib results in increased expression of ILF3 mRNA
CTD
PMID:23228038
NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350
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Ing3
inhibitor of growth family, member 3
increases expression
ISO
torcetrapib results in increased expression of ING3 mRNA
CTD
PMID:23228038
NCBI chr 4:50,477,954...50,505,168
Ensembl chr 4:50,477,962...50,503,715
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Inhba
inhibin subunit beta A
increases expression
ISO
torcetrapib results in increased expression of INHBA mRNA
CTD
PMID:23228038
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Ino80d
INO80 complex subunit D
increases expression
ISO
torcetrapib results in increased expression of INO80D mRNA
CTD
PMID:23228038
NCBI chr 9:64,447,075...64,514,013
Ensembl chr 9:64,457,165...64,515,242
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Irgq
immunity-related GTPase Q
increases expression
ISO
torcetrapib results in increased expression of IRGQ mRNA
CTD
PMID:23228038
NCBI chr 1:80,123,925...80,131,881
Ensembl chr 1:80,123,925...80,131,881
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Itch
itchy E3 ubiquitin protein ligase
increases expression
ISO
torcetrapib results in increased expression of ITCH mRNA
CTD
PMID:23228038
NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
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Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
increases expression
ISO
torcetrapib results in increased expression of ITPR2 mRNA
CTD
PMID:23228038
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
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Itprid2
ITPR interacting domain containing 2
increases expression
ISO
torcetrapib results in increased expression of ITPRID2 mRNA
CTD
PMID:23228038
NCBI chr 3:64,536,707...64,573,978
Ensembl chr 3:64,536,707...64,573,978
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Iws1
interacts with SUPT6H, CTD assembly factor 1
increases expression
ISO
torcetrapib results in increased expression of IWS1 mRNA
CTD
PMID:23228038
NCBI chr18:23,695,496...23,737,363
Ensembl chr18:23,695,425...23,736,172
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Jak1
Janus kinase 1
increases expression
ISO
torcetrapib results in increased expression of JAK1 mRNA
CTD
PMID:23228038
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Jpt2
Jupiter microtubule associated homolog 2
increases expression
ISO
torcetrapib results in increased expression of JPT2 mRNA
CTD
PMID:23228038
NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of JUN mRNA
CTD
PMID:23228038
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
torcetrapib results in increased expression of JUNB mRNA
CTD
PMID:23228038
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Kitlg
KIT ligand
increases expression
ISO
torcetrapib results in increased expression of KITLG mRNA
CTD
PMID:23228038
NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
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Klf2
KLF transcription factor 2
increases expression
ISO
torcetrapib results in increased expression of KLF2 mRNA
CTD
PMID:23228038
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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Klf6
KLF transcription factor 6
increases expression
ISO
torcetrapib results in increased expression of KLF6 mRNA
CTD
PMID:23228038
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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Klf7
KLF transcription factor 7
increases expression
ISO
torcetrapib results in increased expression of KLF7 mRNA
CTD
PMID:23228038
NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
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Klhdc10
kelch domain containing 10
increases expression
ISO
torcetrapib results in increased expression of KLHDC10 mRNA
CTD
PMID:23228038
NCBI chr 4:59,021,300...59,079,118
Ensembl chr 4:59,021,310...59,074,941
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Klhl24
kelch-like family member 24
increases expression
ISO
torcetrapib results in increased expression of KLHL24 mRNA
CTD
PMID:23228038
NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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Kmt2a
lysine methyltransferase 2A
increases expression
ISO
torcetrapib results in increased expression of KMT2A mRNA
CTD
PMID:23228038
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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Lars1
leucyl-tRNA synthetase 1
increases expression
ISO
torcetrapib results in increased expression of LARS1 mRNA
CTD
PMID:23228038
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
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Lima1
LIM domain and actin binding 1
increases expression
ISO
torcetrapib results in increased expression of LIMA1 mRNA
CTD
PMID:23228038
NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473
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Lins1
lines homolog 1
increases expression
ISO
torcetrapib results in increased expression of LINS1 mRNA
CTD
PMID:23228038
NCBI chr 1:120,267,586...120,295,013
Ensembl chr 1:120,267,693...120,293,607
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Lonrf2
LON peptidase N-terminal domain and ring finger 2
increases expression
ISO
torcetrapib results in increased expression of LONRF2 mRNA
CTD
PMID:23228038
NCBI chr 9:41,033,125...41,070,551
Ensembl chr 9:41,034,628...41,070,649
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Lpcat2
lysophosphatidylcholine acyltransferase 2
increases expression
ISO
torcetrapib results in increased expression of LPCAT2 mRNA
CTD
PMID:23228038
NCBI chr19:14,088,389...14,152,742
Ensembl chr19:14,089,686...14,152,829
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Lrp12
LDL receptor related protein 12
increases expression
ISO
torcetrapib results in increased expression of LRP12 mRNA
CTD
PMID:23228038
NCBI chr 7:70,941,068...71,012,409
Ensembl chr 7:70,941,068...71,012,441
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Lsm14b
LSM family member 14B
increases expression
ISO
torcetrapib results in increased expression of LSM14B mRNA
CTD
PMID:23228038
NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432
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Lzic
leucine zipper and CTNNBIP1 domain containing
increases expression
ISO
torcetrapib results in increased expression of LZIC mRNA
CTD
PMID:23228038
NCBI chr 5:159,928,260...159,941,512
Ensembl chr 5:159,920,439...159,939,685
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M6pr
mannose-6-phosphate receptor, cation dependent
increases expression
ISO
torcetrapib results in increased expression of M6PR mRNA
CTD
PMID:23228038
NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
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Map3k2
mitogen activated protein kinase kinase kinase 2
increases expression
ISO
torcetrapib results in increased expression of MAP3K2 mRNA
CTD
PMID:23228038
NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
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Map4
microtubule-associated protein 4
increases expression
ISO
torcetrapib results in increased expression of MAP4 mRNA
CTD
PMID:23228038
NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
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Mbnl2
muscleblind-like splicing regulator 2
increases expression
ISO
torcetrapib results in increased expression of MBNL2 mRNA
CTD
PMID:23228038
NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937
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Mef2a
myocyte enhancer factor 2a
increases expression
ISO
torcetrapib results in increased expression of MEF2A mRNA
CTD
PMID:23228038
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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Mettl16
methyltransferase 16, RNA N6-adenosine
increases expression
ISO
torcetrapib results in increased expression of METTL16 mRNA
CTD
PMID:23228038
NCBI chr10:59,640,915...59,697,291
Ensembl chr10:59,640,972...59,687,061
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
torcetrapib results in increased expression of MITF mRNA
CTD
PMID:23228038
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Mkln1
muskelin 1
increases expression
ISO
torcetrapib results in increased expression of MKLN1 mRNA
CTD
PMID:23228038
NCBI chr 4:59,815,912...60,124,047
Ensembl chr 4:60,002,464...60,123,993
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Mras
muscle RAS oncogene homolog
increases expression
ISO
torcetrapib results in increased expression of MRAS mRNA
CTD
PMID:23228038
NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
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Myl12a
myosin light chain 12A
increases expression
ISO
torcetrapib results in increased expression of MYL12A mRNA
CTD
PMID:23228038
NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
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Myo6
myosin VI
increases expression
ISO
torcetrapib results in increased expression of MYO6 mRNA
CTD
PMID:23228038
NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292
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Myot
myotilin
increases expression
ISO
torcetrapib results in increased expression of MYOT mRNA
CTD
PMID:23228038
NCBI chr18:36,705,244...36,724,849
Ensembl chr18:36,705,314...36,724,841
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Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
increases expression
ISO
torcetrapib results in increased expression of NAA15 mRNA
CTD
PMID:23228038
NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
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Nab2
Ngfi-A binding protein 2
increases expression
ISO
torcetrapib results in increased expression of NAB2 mRNA
CTD
PMID:23228038
NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
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Ncoa3
nuclear receptor coactivator 3
increases expression
ISO
torcetrapib results in increased expression of NCOA3 mRNA
CTD
PMID:23228038
NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
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Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
increases expression
ISO
torcetrapib results in increased expression of NF2 mRNA
CTD
PMID:23228038
NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
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Nfatc2ip
nuclear factor of activated T-cells 2 interacting protein
increases expression
ISO
torcetrapib results in increased expression of NFATC2IP mRNA
CTD
PMID:23228038
NCBI chr 1:180,954,834...180,971,847
Ensembl chr 1:180,955,043...180,971,747
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
torcetrapib results in increased expression of NFE2L2 mRNA
CTD
PMID:23228038
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfil3
nuclear factor, interleukin 3 regulated
increases expression
ISO
torcetrapib results in increased expression of NFIL3 mRNA
CTD
PMID:23228038
NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
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Nfkbiz
NFKB inhibitor zeta
increases expression
ISO
torcetrapib results in increased expression of NFKBIZ mRNA
CTD
PMID:23228038
NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
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Nos3
nitric oxide synthase 3
decreases expression
EXP ISO
torcetrapib results in decreased expression of NOS3 mRNA; torcetrapib results in decreased expression of NOS3 protein
CTD
PMID:21920972
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nox1
NADPH oxidase 1
increases expression
ISO
torcetrapib results in increased expression of NOX1 mRNA; torcetrapib results in increased expression of NOX1 protein
CTD
PMID:25617244
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nox4
NADPH oxidase 4
increases expression
ISO
torcetrapib results in increased expression of NOX4 mRNA
CTD
PMID:25617244
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Npepps
aminopeptidase puromycin sensitive
increases expression
ISO
torcetrapib results in increased expression of NPEPPS mRNA
CTD
PMID:23228038
NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]
CTD
PMID:25617244
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]
CTD
PMID:25617244
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
torcetrapib results in increased expression of NR4A1 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
increases expression
ISO
torcetrapib results in increased expression of NR4A2 mRNA
CTD
PMID:19164467 PMID:23228038 PMID:25617244
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
ISO
torcetrapib results in increased expression of NR4A3 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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Nup62cl
nucleoporin 62 C-terminal like
increases expression
ISO
torcetrapib results in increased expression of NUP62CL mRNA
CTD
PMID:23228038
NCBI chr X:103,668,458...103,724,957
Ensembl chr X:103,668,455...103,724,081
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Odf2l
outer dense fiber of sperm tails 2-like
increases expression
ISO
torcetrapib results in increased expression of ODF2L mRNA
CTD
PMID:23228038
NCBI chr 2:234,036,049...234,072,751
Ensembl chr 2:234,033,652...234,072,747
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Ogfrl1
opioid growth factor receptor-like 1
increases expression
ISO
torcetrapib results in increased expression of OGFRL1 mRNA
CTD
PMID:23228038
NCBI chr 9:25,828,865...25,842,424
Ensembl chr 9:25,828,869...25,842,352
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Ormdl3
ORMDL sphingolipid biosynthesis regulator 3
increases expression
ISO
torcetrapib results in increased expression of ORMDL3 mRNA
CTD
PMID:23228038
NCBI chr10:83,590,052...83,596,035
Ensembl chr10:83,590,071...83,598,620
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Otud4
OTU deubiquitinase 4
increases expression
ISO
torcetrapib results in increased expression of OTUD4 mRNA
CTD
PMID:23228038
NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815
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Palld
palladin, cytoskeletal associated protein
increases expression
ISO
torcetrapib results in increased expression of PALLD mRNA
CTD
PMID:23228038
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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Papolg
poly(A) polymerase gamma
increases expression
ISO
torcetrapib results in increased expression of PAPOLG mRNA
CTD
PMID:23228038
NCBI chr14:97,827,712...97,861,024
Ensembl chr14:97,827,712...97,861,024
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Paqr9
progestin and adipoQ receptor family member 9
increases expression
ISO
torcetrapib results in increased expression of PAQR9 mRNA
CTD
PMID:23228038
NCBI chr 8:96,114,249...96,116,546
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Patl1
PAT1 homolog 1, processing body mRNA decay factor
increases expression
ISO
torcetrapib results in increased expression of PATL1 mRNA
CTD
PMID:23228038
NCBI chr 1:208,831,115...208,862,904
Ensembl chr 1:208,831,115...208,862,857
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Pcm1
pericentriolar material 1
increases expression
ISO
torcetrapib results in increased expression of PCM1 mRNA
CTD
PMID:23228038
NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
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Pcyt1a
phosphate cytidylyltransferase 1A, choline
increases expression
ISO
torcetrapib results in increased expression of PCYT1A mRNA
CTD
PMID:23228038
NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
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Pde4b
phosphodiesterase 4B
increases expression
ISO
torcetrapib results in increased expression of PDE4B mRNA
CTD
PMID:23228038
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Pde4d
phosphodiesterase 4D
increases expression
ISO
torcetrapib results in increased expression of PDE4D mRNA
CTD
PMID:23228038
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
torcetrapib results in increased expression of PDK4 mRNA
CTD
PMID:23228038
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Pdlim5
PDZ and LIM domain 5
increases expression
ISO
torcetrapib results in increased expression of PDLIM5 mRNA
CTD
PMID:23228038
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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Pdp1
pyruvate dehydrogenase phosphatase catalytic subunit 1
increases expression
ISO
torcetrapib results in increased expression of PDP1 mRNA
CTD
PMID:23228038
NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217
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Per2
period circadian regulator 2
increases expression
ISO
torcetrapib results in increased expression of PER2 mRNA
CTD
PMID:23228038
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Pgm2l1
phosphoglucomutase 2-like 1
increases expression
ISO
torcetrapib results in increased expression of PGM2L1 mRNA
CTD
PMID:23228038
NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902
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Phactr2
phosphatase and actin regulator 2
increases expression
ISO
torcetrapib results in increased expression of PHACTR2 mRNA
CTD
PMID:23228038
NCBI chr 1:7,591,254...7,860,431
Ensembl chr 1:7,597,927...7,860,289
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Phc3
polyhomeotic homolog 3
increases expression
ISO
torcetrapib results in increased expression of PHC3 mRNA
CTD
PMID:23228038
NCBI chr 2:112,408,709...112,483,719
Ensembl chr 2:112,408,531...112,476,540
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Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
increases expression
ISO
torcetrapib results in increased expression of PIP4K2B mRNA
CTD
PMID:23228038
NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938
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Pld6
phospholipase D family, member 6
increases expression
ISO
torcetrapib results in increased expression of PLD6 mRNA
CTD
PMID:23228038
NCBI chr10:44,578,536...44,581,187
Ensembl chr10:44,577,675...44,581,077
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Plekha2
pleckstrin homology domain containing A2
increases expression
ISO
torcetrapib results in increased expression of PLEKHA2 mRNA
CTD
PMID:23228038
NCBI chr16:66,938,684...67,000,661
Ensembl chr16:66,939,109...66,999,395
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Plk2
polo-like kinase 2
increases expression
ISO
torcetrapib results in increased expression of PLK2 mRNA
CTD
PMID:23228038
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
torcetrapib results in increased expression of PMAIP1 mRNA
CTD
PMID:23228038
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Poc1b
POC1 centriolar protein B
increases expression
ISO
torcetrapib results in increased expression of POC1B mRNA
CTD
PMID:23228038
NCBI chr 7:33,924,112...34,025,908
Ensembl chr 7:33,924,189...34,025,903
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of PPARG mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of PPARG mRNA]
CTD
PMID:25617244
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppfibp1
PPFIA binding protein 1
increases expression
ISO
torcetrapib results in increased expression of PPFIBP1 mRNA
CTD
PMID:23228038
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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Ppia
peptidylprolyl isomerase A
increases expression
ISO
torcetrapib results in increased expression of PPIA mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Prelid3b
PRELI domain containing 3B
increases expression
ISO
torcetrapib results in increased expression of PRELID3B mRNA
CTD
PMID:23228038
NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181
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Prickle1
prickle planar cell polarity protein 1
increases expression
ISO
torcetrapib results in increased expression of PRICKLE1 mRNA
CTD
PMID:23228038
NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
increases expression
ISO
torcetrapib results in increased expression of PRKACB mRNA
CTD
PMID:23228038
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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Prrc2c
proline-rich coiled-coil 2C
increases expression
ISO
torcetrapib results in increased expression of PRRC2C mRNA
CTD
PMID:23228038
NCBI chr13:75,003,995...75,073,701
Ensembl chr13:75,004,010...75,073,643
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Psmd7
proteasome 26S subunit, non-ATPase 7
increases expression
ISO
torcetrapib results in increased expression of PSMD7 mRNA
CTD
PMID:23228038
NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
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Ptar1
protein prenyltransferase alpha subunit repeat containing 1
increases expression
ISO
torcetrapib results in increased expression of PTAR1 mRNA
CTD
PMID:23228038
NCBI chr 1:221,283,306...221,326,861
Ensembl chr 1:221,283,415...221,327,073
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Ptp4a1
protein tyrosine phosphatase 4A1
increases expression
ISO
torcetrapib results in increased expression of PTP4A1 mRNA
CTD
PMID:23228038
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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Ptpn14
protein tyrosine phosphatase, non-receptor type 14
increases expression
ISO
torcetrapib results in increased expression of PTPN14 mRNA
CTD
PMID:23228038
NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
increases expression
ISO
torcetrapib results in increased expression of PTPN2 mRNA
CTD
PMID:23228038
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
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Purb
purine rich element binding protein B
increases expression
ISO
torcetrapib results in increased expression of PURB mRNA
CTD
PMID:23228038
NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432
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Pvr
PVR cell adhesion molecule
increases expression
ISO
torcetrapib results in increased expression of PVR mRNA
CTD
PMID:23228038
NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
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Pygo1
pygopus family PHD finger 1
increases expression
ISO
torcetrapib results in increased expression of PYGO1 mRNA
CTD
PMID:23228038
NCBI chr 8:73,666,210...73,684,873
Ensembl chr 8:73,665,593...73,684,869
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Rab3b
RAB3B, member RAS oncogene family
increases expression
ISO
torcetrapib results in increased expression of RAB3B mRNA
CTD
PMID:23228038
NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
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Rab5c
RAB5C, member RAS oncogene family
increases expression
ISO
torcetrapib results in increased expression of RAB5C mRNA
CTD
PMID:23228038
NCBI chr10:85,642,553...85,666,142
Ensembl chr10:85,642,809...85,666,103
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Rad21
RAD21 cohesin complex component
increases expression
ISO
torcetrapib results in increased expression of RAD21 mRNA
CTD
PMID:23228038
NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
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Rarres2
retinoic acid receptor responder 2
multiple interactions increases expression
ISO
NSC 74859 inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of RARRES2 mRNA]
CTD
PMID:25617244
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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Rbbp6
RB binding protein 6, ubiquitin ligase
increases expression
ISO
torcetrapib results in increased expression of RBBP6 mRNA
CTD
PMID:23228038
NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
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Rbbp9
RB binding protein 9, serine hydrolase
increases expression
ISO
torcetrapib results in increased expression of RBBP9 mRNA
CTD
PMID:23228038
NCBI chr 3:131,925,095...131,939,042
Ensembl chr 3:131,925,341...131,932,156
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Rbfox2
RNA binding fox-1 homolog 2
increases expression
ISO
torcetrapib results in increased expression of RBFOX2 mRNA
CTD
PMID:23228038
NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691
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Rbm39
RNA binding motif protein 39
increases expression
ISO
torcetrapib results in increased expression of RBM39 mRNA
CTD
PMID:23228038
NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
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Rel
REL proto-oncogene, NF-kB subunit
increases expression
ISO
torcetrapib results in increased expression of REL mRNA
CTD
PMID:23228038
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rgs2
regulator of G-protein signaling 2
increases expression
ISO
torcetrapib results in increased expression of RGS2 mRNA
CTD
PMID:23228038
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rhob
ras homolog family member B
increases expression
ISO
torcetrapib results in increased expression of RHOB mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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Rif1
replication timing regulatory factor 1
increases expression
ISO
torcetrapib results in increased expression of RIF1 mRNA
CTD
PMID:23228038
NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
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Rnf13
ring finger protein 13
increases expression
ISO
torcetrapib results in increased expression of RNF13 mRNA
CTD
PMID:23228038
NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801
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Rnf152
ring finger protein 152
increases expression
ISO
torcetrapib results in increased expression of RNF152 mRNA
CTD
PMID:23228038
NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113
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Rnf19a
ring finger protein 19A, RBR E3 ubiquitin protein ligase
increases expression
ISO
torcetrapib results in increased expression of RNF19A mRNA
CTD
PMID:23228038
NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222
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Rsl24d1
ribosomal L24 domain containing 1
increases expression
ISO
torcetrapib results in increased expression of RSL24D1 mRNA
CTD
PMID:23228038
NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001
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Rsrc1
arginine and serine rich coiled-coil 1
increases expression
ISO
torcetrapib results in increased expression of RSRC1 mRNA
CTD
PMID:23228038
NCBI chr 2:151,226,821...151,632,771
Ensembl chr 2:151,231,156...151,632,765
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Rundc1
RUN domain containing 1
increases expression
ISO
torcetrapib results in increased expression of RUNDC1 mRNA
CTD
PMID:23228038
NCBI chr10:86,361,635...86,375,446
Ensembl chr10:86,361,051...86,370,878
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S1pr3
sphingosine-1-phosphate receptor 3
increases expression
ISO
torcetrapib results in increased expression of S1PR3 mRNA
CTD
PMID:23228038
NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
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Samd8
sterile alpha motif domain containing 8
increases expression
ISO
torcetrapib results in increased expression of SAMD8 mRNA
CTD
PMID:23228038
NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379 Ensembl chr15:2,512,105...2,515,379
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Sart3
spliceosome associated factor 3, U4/U6 recycling protein
increases expression
ISO
torcetrapib results in increased expression of SART3 mRNA
CTD
PMID:23228038
NCBI chr12:42,859,026...42,887,041
Ensembl chr12:42,859,305...42,887,038
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Sav1
salvador family WW domain containing protein 1
increases expression
ISO
torcetrapib results in increased expression of SAV1 mRNA
CTD
PMID:23228038
NCBI chr 6:88,478,536...88,500,121
Ensembl chr 6:88,478,539...88,499,968
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Scaf11
SR-related CTD-associated factor 11
increases expression
ISO
torcetrapib results in increased expression of SCAF11 mRNA
CTD
PMID:23228038
NCBI chr 7:127,571,678...127,624,089
Ensembl chr 7:127,574,463...127,624,101
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Scai
suppressor of cancer cell invasion
increases expression
ISO
torcetrapib results in increased expression of SCAI mRNA
CTD
PMID:23228038
NCBI chr 3:22,813,283...22,925,337
Ensembl chr 3:22,819,574...22,925,363
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Sel1l
SEL1L adaptor subunit of SYVN1 ubiquitin ligase
increases expression
ISO
torcetrapib results in increased expression of SEL1L mRNA
CTD
PMID:23228038
NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
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Septin11
septin 11
increases expression
ISO
torcetrapib results in increased expression of SEPTIN11 mRNA
CTD
PMID:23228038
NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853
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Setx
senataxin
increases expression
ISO
torcetrapib results in increased expression of SETX mRNA
CTD
PMID:23228038
NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
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Sgcb
sarcoglycan, beta
increases expression
ISO
torcetrapib results in increased expression of SGCB mRNA
CTD
PMID:23228038
NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
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Sik1
salt-inducible kinase 1
increases expression
ISO
torcetrapib results in increased expression of SIK1 mRNA
CTD
PMID:23228038
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Sike1
suppressor of IKBKE 1
increases expression
ISO
torcetrapib results in increased expression of SIKE1 mRNA
CTD
PMID:23228038
NCBI chr 2:190,518,002...190,525,833
Ensembl chr 2:190,518,002...190,525,832
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Sinhcaf
SIN3-HDAC complex associated factor
increases expression
ISO
torcetrapib results in increased expression of SINHCAF mRNA
CTD
PMID:23228038
NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276
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Slain2
SLAIN motif family, member 2
increases expression
ISO
torcetrapib results in increased expression of SLAIN2 mRNA
CTD
PMID:23228038
NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678
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Slc25a13
solute carrier family 25 member 13
increases expression
ISO
torcetrapib results in increased expression of SLC25A13 mRNA
CTD
PMID:23228038
NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
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Slc2a3
solute carrier family 2 member 3
increases expression
ISO
torcetrapib results in increased expression of SLC2A3 mRNA
CTD
PMID:23228038
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc30a4
solute carrier family 30 member 4
increases expression
ISO
torcetrapib results in increased expression of SLC30A4 mRNA
CTD
PMID:23228038
NCBI chr 3:109,753,270...109,775,306
Ensembl chr 3:109,753,273...109,775,306
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Slc39a6
solute carrier family 39 member 6
increases expression
ISO
torcetrapib results in increased expression of SLC39A6 mRNA
CTD
PMID:23228038
NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417
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Smarcc1
SWI/SNF related BAF chromatin remodeling complex subunit C1
increases expression
ISO
torcetrapib results in increased expression of SMARCC1 mRNA
CTD
PMID:23228038
NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720
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Smc1a
structural maintenance of chromosomes 1A
increases expression
ISO
torcetrapib results in increased expression of SMC1A mRNA
CTD
PMID:23228038
NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056
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Smc3
structural maintenance of chromosomes 3
increases expression
ISO
torcetrapib results in increased expression of SMC3 mRNA
CTD
PMID:23228038
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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Snapc1
small nuclear RNA activating complex, polypeptide 1
increases expression
ISO
torcetrapib results in increased expression of SNAPC1 mRNA
CTD
PMID:23228038
NCBI chr 6:92,684,785...92,710,772
Ensembl chr 6:92,684,752...92,707,746
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Snx13
sorting nexin 13
increases expression
ISO
torcetrapib results in increased expression of SNX13 mRNA
CTD
PMID:23228038
NCBI chr 6:51,758,258...51,862,260
Ensembl chr 6:51,753,036...51,860,224
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Socs1
suppressor of cytokine signaling 1
increases expression
ISO
torcetrapib results in increased expression of SOCS1 mRNA
CTD
PMID:23228038
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
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Spred1
sprouty-related, EVH1 domain containing 1
increases expression
ISO
torcetrapib results in increased expression of SPRED1 mRNA
CTD
PMID:23228038
NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718
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Spry2
sprouty RTK signaling antagonist 2
increases expression
ISO
torcetrapib results in increased expression of SPRY2 mRNA
CTD
PMID:23228038
NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009
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Srek1
splicing regulatory glutamic acid and lysine rich protein 1
increases expression
ISO
torcetrapib results in increased expression of SREK1 mRNA
CTD
PMID:23228038
NCBI chr 2:34,849,548...34,885,120
Ensembl chr 2:34,852,458...34,884,972
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Ssr3
signal sequence receptor subunit 3
increases expression
ISO
torcetrapib results in increased expression of SSR3 mRNA
CTD
PMID:23228038
NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132
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Star
steroidogenic acute regulatory protein
multiple interactions increases expression
ISO
2-acetylphenothiazine inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; NSC 74859 inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; Rotenone inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]; setanaxib inhibits the reaction [torcetrapib results in increased expression of STAR mRNA] torcetrapib results in increased expression of STAR mRNA; torcetrapib results in increased expression of STAR protein
CTD
PMID:25617244 PMID:28235592
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat3
signal transducer and activator of transcription 3
increases phosphorylation
ISO
torcetrapib results in increased phosphorylation of STAT3 protein
CTD
PMID:25617244
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stk4
serine/threonine kinase 4
increases expression
ISO
torcetrapib results in increased expression of STK4 mRNA
CTD
PMID:23228038
NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
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Ston2
stonin 2
increases expression
ISO
torcetrapib results in increased expression of STON2 mRNA
CTD
PMID:23228038
NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376
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Sts
steroid sulfatase
increases expression
ISO
torcetrapib results in increased expression of STS mRNA
CTD
PMID:23228038
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Svip
small VCP interacting protein
increases expression
ISO
torcetrapib results in increased expression of SVIP mRNA
CTD
PMID:23228038
NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116
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Szrd1
SUZ RNA binding domain containing 1
increases expression
ISO
torcetrapib results in increased expression of SZRD1 mRNA
CTD
PMID:23228038
NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252
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Tacc1
transforming, acidic coiled-coil containing protein 1
increases expression
ISO
torcetrapib results in increased expression of TACC1 mRNA
CTD
PMID:23228038
NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733
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Tasp1
taspase 1
increases expression
ISO
torcetrapib results in increased expression of TASP1 mRNA
CTD
PMID:23228038
NCBI chr 3:127,176,416...127,408,039
Ensembl chr 3:127,176,692...127,399,600
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Tbl1xr1
TBL1X/Y related 1
increases expression
ISO
torcetrapib results in increased expression of TBL1XR1 mRNA
CTD
PMID:23228038
NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055
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Tcaf1
TRPM8 channel-associated factor 1
increases expression
ISO
torcetrapib results in increased expression of TCAF1 mRNA
CTD
PMID:23228038
NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309
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Tcf4
transcription factor 4
increases expression
ISO
torcetrapib results in increased expression of TCF4 mRNA
CTD
PMID:23228038
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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Tent5a
terminal nucleotidyltransferase 5A
increases expression
ISO
torcetrapib results in increased expression of TENT5A mRNA
CTD
PMID:23228038
NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045
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Tfrc
transferrin receptor
increases expression
ISO
torcetrapib results in increased expression of TFRC mRNA
CTD
PMID:23228038
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb2
transforming growth factor, beta 2
increases expression
ISO
torcetrapib results in increased expression of TGFB2 mRNA
CTD
PMID:23228038
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tgfbr2
transforming growth factor, beta receptor 2
increases expression
ISO
torcetrapib results in increased expression of TGFBR2 mRNA
CTD
PMID:23228038
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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Tgoln2
trans-golgi network protein 2
increases expression
ISO
torcetrapib results in increased expression of TGOLN2 mRNA
CTD
PMID:23228038
NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
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Thumpd3
THUMP domain containing 3
increases expression
ISO
torcetrapib results in increased expression of THUMPD3 mRNA
CTD
PMID:23228038
NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
torcetrapib results in increased expression of TIPARP mRNA
CTD
PMID:23228038
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tle4
TLE family member 4, transcriptional corepressor
increases expression
ISO
torcetrapib results in increased expression of TLE4 mRNA
CTD
PMID:23228038
NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862
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Tmem165
transmembrane protein 165
increases expression
ISO
torcetrapib results in increased expression of TMEM165 mRNA
CTD
PMID:23228038
NCBI chr14:31,993,489...32,018,717
Ensembl chr14:31,993,493...32,018,717
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Tnfrsf12a
TNF receptor superfamily member 12A
increases expression
ISO
torcetrapib results in increased expression of TNFRSF12A mRNA
CTD
PMID:23228038
NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
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Tnpo2
transportin 2
increases expression
ISO
torcetrapib results in increased expression of TNPO2 mRNA
CTD
PMID:23228038
NCBI chr19:23,099,398...23,119,696
Ensembl chr19:23,099,401...23,119,596
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Tob1
transducer of ErbB-2.1
increases expression
ISO
torcetrapib results in increased expression of TOB1 mRNA
CTD
PMID:23228038
NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
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Top3a
DNA topoisomerase III alpha
increases expression
ISO
torcetrapib results in increased expression of TOP3A mRNA
CTD
PMID:23228038
NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559
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Tp53bp1
tumor protein p53 binding protein 1
increases expression
ISO
torcetrapib results in increased expression of TP53BP1 mRNA
CTD
PMID:23228038
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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Tpm4
tropomyosin 4
increases expression
ISO
torcetrapib results in increased expression of TPM4 mRNA
CTD
PMID:23228038
NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
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Tpp2
tripeptidyl peptidase 2
increases expression
ISO
torcetrapib results in increased expression of TPP2 mRNA
CTD
PMID:23228038
NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
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Tpr
translocated promoter region, nuclear basket protein
increases expression
ISO
torcetrapib results in increased expression of TPR mRNA
CTD
PMID:23228038
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Trib1
tribbles pseudokinase 1
increases expression
ISO
torcetrapib results in increased expression of TRIB1 mRNA
CTD
PMID:23228038
NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
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Trim2
tripartite motif-containing 2
increases expression
ISO
torcetrapib results in increased expression of TRIM2 mRNA
CTD
PMID:23228038
NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
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Trim23
tripartite motif-containing 23
increases expression
ISO
torcetrapib results in increased expression of TRIM23 mRNA
CTD
PMID:23228038
NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743
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Ttc3
tetratricopeptide repeat domain 3
increases expression
ISO
torcetrapib results in increased expression of TTC3 mRNA
CTD
PMID:23228038
NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975
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Tut7
terminal uridylyl transferase 7
increases expression
ISO
torcetrapib results in increased expression of TUT7 mRNA
CTD
PMID:23228038
NCBI chr17:4,849,287...4,903,542
Ensembl chr17:4,849,283...4,903,169
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Twf1
twinfilin actin-binding protein 1
increases expression
ISO
torcetrapib results in increased expression of TWF1 mRNA
CTD
PMID:23228038
NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894
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Uba6
ubiquitin-like modifier activating enzyme 6
increases expression
ISO
torcetrapib results in increased expression of UBA6 mRNA
CTD
PMID:23228038
NCBI chr14:21,884,039...21,947,857
Ensembl chr14:21,884,039...21,947,857
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Ube2w
ubiquitin-conjugating enzyme E2W
increases expression
ISO
torcetrapib results in increased expression of UBE2W mRNA
CTD
PMID:23228038
NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965
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Ubxn4
UBX domain protein 4
increases expression
ISO
torcetrapib results in increased expression of UBXN4 mRNA
CTD
PMID:23228038
NCBI chr13:39,740,064...39,772,493
Ensembl chr13:39,740,107...39,772,491
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Uevld
UEV and lactate/malate dehyrogenase domains
increases expression
ISO
torcetrapib results in increased expression of UEVLD mRNA
CTD
PMID:23228038
NCBI chr 1:97,454,188...97,486,004
Ensembl chr 1:97,453,946...97,486,000
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Upf1
UPF1, RNA helicase and ATPase
increases expression
ISO
torcetrapib results in increased expression of UPF1 mRNA
CTD
PMID:23228038
NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
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Usp4
ubiquitin specific peptidase 4
increases expression
ISO
torcetrapib results in increased expression of USP4 mRNA
CTD
PMID:19164467 PMID:23228038
NCBI chr 8:109,035,402...109,079,382
Ensembl chr 8:109,036,099...109,080,427
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Usp42
ubiquitin specific peptidase 42
increases expression
ISO
torcetrapib results in increased expression of USP42 mRNA
CTD
PMID:23228038
NCBI chr12:10,800,864...10,840,785
Ensembl chr12:10,802,581...10,840,785
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Usp49
ubiquitin specific peptidase 49
increases expression
ISO
torcetrapib results in increased expression of USP49 mRNA
CTD
PMID:23228038
NCBI chr 9:13,305,640...13,366,132
Ensembl chr 9:13,308,178...13,366,132
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Vps13c
vacuolar protein sorting 13 homolog C
increases expression
ISO
torcetrapib results in increased expression of VPS13C mRNA
CTD
PMID:23228038
NCBI chr 8:68,478,366...68,651,893
Ensembl chr 8:68,478,395...68,651,895
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Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
increases expression
ISO
torcetrapib results in increased expression of WARS2 mRNA
CTD
PMID:23228038
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
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Wsb1
WD repeat and SOCS box-containing 1
increases expression
ISO
torcetrapib results in increased expression of WSB1 mRNA
CTD
PMID:23228038
NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
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Zbtb21
zinc finger and BTB domain containing 21
increases expression
ISO
torcetrapib results in increased expression of ZBTB21 mRNA
CTD
PMID:23228038
NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996
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Zc3h7a
zinc finger CCCH type containing 7 A
increases expression
ISO
torcetrapib results in increased expression of ZC3H7A mRNA
CTD
PMID:23228038
NCBI chr10:4,473,177...4,512,668
Ensembl chr10:4,473,203...4,512,665
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Zfp277
zinc finger protein 277
increases expression
ISO
torcetrapib results in increased expression of ZNF277 mRNA
CTD
PMID:23228038
NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765
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Zfp36l2
zinc finger protein 36, C3H type-like 2
increases expression
ISO
torcetrapib results in increased expression of ZFP36L2 mRNA
CTD
PMID:23228038
NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064
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Zfp46
zinc finger protein 46
increases expression
ISO
torcetrapib results in increased expression of ZNF436 mRNA
CTD
PMID:23228038
NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459
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Zfp641
zinc finger protein 641
increases expression
ISO
torcetrapib results in increased expression of ZNF641 mRNA
CTD
PMID:23228038
NCBI chr 7:129,434,576...129,444,847
Ensembl chr 7:129,434,576...129,444,644
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Zfp655
zinc finger protein 655
increases expression
ISO
torcetrapib results in increased expression of ZNF655 mRNA
CTD
PMID:23228038
NCBI chr12:9,349,985...9,375,449
Ensembl chr12:9,357,639...9,374,569
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Zfp704
zinc finger protein 704
increases expression
ISO
torcetrapib results in increased expression of ZNF704 mRNA
CTD
PMID:23228038
NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282
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Zfp800
zinc finger protein 800
increases expression
ISO
torcetrapib results in increased expression of ZNF800 mRNA
CTD
PMID:23228038
NCBI chr 4:56,798,326...56,849,766
Ensembl chr 4:56,826,997...56,849,791
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Zfr
zinc finger RNA binding protein
increases expression
ISO
torcetrapib results in increased expression of ZFR mRNA
CTD
PMID:23228038
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
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Znf740
zinc finger protein 740
increases expression
ISO
torcetrapib results in increased expression of ZNF740 mRNA
CTD
PMID:23228038
NCBI chr 7:133,337,038...133,347,594
Ensembl chr 7:133,336,671...133,347,589
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