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Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:peripheral nervous system drug
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Accession:CHEBI:49110 term browser browse the term
Definition:A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
Synonyms:related_synonym: peripheral nervous system agent;   peripheral nervous system drugs



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(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase decreases expression
increases methylation
EXP Nicotine results in decreased expression of AACS mRNA
Nicotine results in increased methylation of AACS promoter
CTD PMID:26776438 NCBI chr12:36,774,471...36,817,835
Ensembl chr12:36,774,471...36,822,543
JBrowse link
G Aatk apoptosis-associated tyrosine kinase increases expression ISO Nicotine results in increased expression of AATK mRNA CTD PMID:18247414 NCBI chr10:105,789,171...105,825,634
Ensembl chr10:105,785,469...105,825,618
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]
Nicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 protein
CTD PMID:30036686 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]
Nicotine results in increased expression of ABCG1 protein
Nicotine results in decreased expression of ABCG1 mRNA; Nicotine results in decreased expression of ABCG1 protein
CTD PMID:30036686 PMID:31629012 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Nicotine results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 increases expression ISO Nicotine results in increased expression of ABTB3 mRNA CTD PMID:21955143 PMID:23825647 NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA] CTD PMID:20230807 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Nicotine results in increased expression of ACACA mRNA CTD PMID:24368177 PMID:29155039 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Acan aggrecan decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of ACAN mRNA; Nicotine results in decreased expression of ACAN protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779
JBrowse link
G Ace angiotensin I converting enzyme increases expression ISO Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942
JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of ACHE protein
Nicotine results in increased activity of ACHE protein
Nicotine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
CTD PMID:20097188 PMID:21633116 PMID:23033686 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Nicotine results in decreased expression of ACOT13 mRNA CTD PMID:17997037 NCBI chr17:40,668,404...40,680,876
Ensembl chr17:40,668,316...40,680,876
JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Nicotine results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:53,233,948...53,251,959
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases splicing ISO Nicotine results in increased splicing of ACSL1 mRNA alternative form CTD PMID:23825647 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions
increases expression
ISO
EXP
Mecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]
Nicotine results in increased expression of ACSL6 mRNA
CTD PMID:22205969 NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,940,747...39,002,873
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of ACTA1 mRNA
Nicotine results in decreased expression of ACTA1 mRNA
CTD PMID:17997037 PMID:27782041 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Quartz results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Arginine results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 mRNA; Nicotine results in increased expression of ACTA2 protein
CTD PMID:33640489 PMID:34153408 PMID:36720419 PMID:36868510 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Actb actin, beta increases expression ISO Nicotine results in increased expression of ACTB mRNA CTD PMID:17997037 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:255,179,242...255,199,459
JBrowse link
G Actrt2 actin-related protein T2 decreases expression EXP Nicotine results in decreased expression of ACTRT2 mRNA CTD PMID:27782041 NCBI chr 5:170,518,470...170,519,870
Ensembl chr 5:170,518,165...170,521,164
JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein] CTD PMID:31857090 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Nicotine results in increased expression of ADAM19 mRNA CTD PMID:23825647 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:34,913,154...34,972,366
Ensembl chr19:34,914,322...34,936,743
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Nicotine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:204,059,218...204,102,869
Ensembl chr 1:204,059,367...204,102,869
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO Nicotine results in increased expression of ADGRG1 mRNA CTD PMID:23825647 NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:41,107,162...41,148,752
Ensembl chr19:41,109,117...41,148,896
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Nicotine results in increased expression of ADIPOR2 mRNA CTD PMID:22265867 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666
JBrowse link
G Adk adenosine kinase increases expression ISO Nicotine results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,912,544...3,295,745
JBrowse link
G Adm2 adrenomedullin 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of ADM2 protein CTD PMID:19910445 NCBI chr 7:122,272,808...122,274,594
Ensembl chr 7:122,272,808...122,274,594
JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA] CTD PMID:20230807 NCBI chr 3:177,310,258...177,340,379
Ensembl chr 3:177,310,258...177,336,188
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Nicotine results in decreased expression of ADORA2A mRNA CTD PMID:21955143 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
increases expression
ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB1 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB2 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein increases expression ISO Nicotine results in increased expression of ADTRP mRNA CTD PMID:23825647 NCBI chr17:23,113,578...23,199,616
Ensembl chr17:23,135,809...23,216,622
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Nicotine results in increased expression of AGTR1B mRNA CTD PMID:22728133 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression
affects expression
EXP Nicotine results in decreased expression of AGTR2 mRNA; Nicotine results in decreased expression of AGTR2 protein
Nicotine affects the expression of AGTR2 protein
CTD PMID:19429393 PMID:22691361 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Nicotine results in increased expression of AHR mRNA CTD PMID:34171359 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor decreases expression EXP Nicotine results in decreased expression of AHRR protein CTD PMID:35577041 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866
JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Nicotine results in increased expression of AK3 mRNA CTD PMID:17456735 NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183
JBrowse link
G Ak5 adenylate kinase 5 increases expression ISO Nicotine results in increased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:244,057,240...244,241,372
Ensembl chr 2:244,057,240...244,241,366
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of AKR1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases expression
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein
IGF1 protein inhibits the reaction [Nicotine results in decreased phosphorylation of AKT1 protein]
Nicotine results in increased expression of AKT1 mRNA
CTD PMID:12511591 PMID:15983034 PMID:20727180 PMID:24095863 PMID:30836163 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression
increases expression
EXP
ISO
Nicotine affects the expression of AKT2 mRNA
Nicotine results in increased expression of AKT2 mRNA
CTD PMID:31945395 PMID:31972234 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO Nicotine results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041
JBrowse link
G Alb albumin increases expression
multiple interactions
decreases expression
EXP
ISO
Nicotine results in increased expression of ALB protein
dexpanthenol inhibits the reaction [Nicotine results in decreased expression of ALB protein]
CTD PMID:25662863 PMID:36720419 PMID:38229321 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity
multiple interactions
ISO Nicotine results in increased activity of ALDH1A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]
CTD PMID:20230807 PMID:23219715 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Nicotine results in increased expression of ALOX12 mRNA CTD PMID:16254210 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]
Nicotine results in increased expression of ALOX5 mRNA; Nicotine results in increased expression of ALOX5 protein
CTD PMID:14569062 PMID:20061081 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Nicotine results in decreased expression of ALPL mRNA CTD PMID:39207236 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO Nicotine results in increased expression of AMD1 mRNA CTD PMID:16949557 NCBI chr20:45,250,289...45,324,939
Ensembl chr20:45,250,289...45,265,982
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 decreases expression ISO Nicotine results in decreased expression of AMHR2 mRNA CTD PMID:18247414 NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:135,457,922...135,471,104
JBrowse link
G Angpt4 angiopoietin 4 increases expression ISO Nicotine results in increased expression of ANGPT4 mRNA CTD PMID:23825647 NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:160,880,728...160,913,921
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Nicotine results in decreased expression of ANGPTL4 mRNA CTD PMID:32512034 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681
JBrowse link
G Ano3 anoctamin 3 decreases expression ISO Nicotine results in decreased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:117,690,242...118,004,695
Ensembl chr 3:117,692,103...118,004,675
JBrowse link
G Anxa1 annexin A1 decreases expression
increases expression
EXP Nicotine results in decreased expression of ANXA1 mRNA
Nicotine results in increased expression of ANXA1 protein
CTD PMID:26776438 PMID:39824327 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase decreases expression ISO Nicotine results in decreased expression of APEH mRNA CTD PMID:16949557 NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:117,652,393...117,661,711
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
JBrowse link
G Api5 apoptosis inhibitor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of API5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of API5 mRNA] CTD PMID:20230807 NCBI chr 3:100,833,417...100,858,580
Ensembl chr 3:100,833,417...100,858,580
JBrowse link
G Apoe apolipoprotein E increases expression ISO Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
decreases expression
ISO
EXP
[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]
Nicotine results in decreased expression of APP protein alternative form
Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP protein
CTD PMID:16474004 PMID:16627626 PMID:17135361 PMID:29618714 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Nicotine results in increased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO Nicotine results in increased expression of ARC mRNA CTD PMID:23825647 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220
JBrowse link
G Arf1 ARF GTPase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:44,497,543...44,513,994 JBrowse link
G Arf3 ARF GTPase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF3 mRNA] CTD PMID:20230807 NCBI chr 7:131,765,039...131,792,075
Ensembl chr 7:131,750,672...131,770,123
JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Nicotine results in increased expression of ARGLU1 mRNA CTD PMID:16949557 NCBI chr16:87,455,097...87,479,148
Ensembl chr16:87,455,113...87,479,148
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA CTD PMID:28065790 NCBI chr 2:148,889,405...149,000,538
Ensembl chr 2:148,889,423...149,000,538
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 decreases expression ISO Nicotine results in decreased expression of ARHGEF7 mRNA CTD PMID:12588870 NCBI chr16:84,373,123...84,484,759
Ensembl chr16:84,373,123...84,484,597
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression ISO Nicotine results in decreased expression of ARID1A mRNA CTD PMID:17997037 NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:151,192,014...151,265,386
JBrowse link
G Arl15 ARF like GTPase 15 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA CTD PMID:28065790 NCBI chr 2:47,171,377...47,555,666
Ensembl chr 2:47,094,900...47,555,666
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression EXP Nicotine results in decreased expression of ARNT protein CTD PMID:35577041 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 decreases expression ISO Nicotine results in decreased expression of ARPP21 mRNA CTD PMID:21955143 NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:120,912,970...121,031,357
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:16862215 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859
JBrowse link
G Arvcf ARVCF, delta catenin family member decreases response to substance ISO ARVCF gene mutant form results in decreased susceptibility to Nicotine CTD PMID:38025780 NCBI chr11:96,092,451...96,150,144
Ensembl chr11:96,092,451...96,150,163
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP Nicotine results in decreased expression of ASCL1 mRNA CTD PMID:28555334 NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:23,790,360...23,798,231
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression EXP Nicotine results in decreased expression of ASCL2 mRNA CTD PMID:24368670 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856
JBrowse link
G Aspm assembly factor for spindle microtubules multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA] CTD PMID:20230807 NCBI chr13:53,625,584...53,674,489
Ensembl chr13:53,625,584...53,674,489
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Nicotine results in increased expression of ATF3 mRNA CTD PMID:17456735 PMID:24927667 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein] CTD PMID:18477628 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions
increases expression
ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 4:95,241,933...95,244,028
Ensembl chr 4:95,241,933...95,244,019
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nicotine results in decreased expression of ATP5F1A protein CTD PMID:28681937 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases splicing ISO Nicotine results in increased splicing of ATP5F1E mRNA alternative form CTD PMID:23825647 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP6V0A4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0A4 mRNA] CTD PMID:20230807 NCBI chr 4:67,727,145...67,809,092
Ensembl chr 4:67,727,145...67,809,092
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA] CTD PMID:20230807 NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:177,779,203...178,023,661
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718
JBrowse link
G Atrn attractin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:138,563,271...138,697,360
Ensembl chr 3:138,563,312...138,697,360
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression
decreases expression
ISO Nicotine results in increased expression of ATRX mRNA
Nicotine results in decreased expression of ATRX mRNA
CTD PMID:16949557 PMID:21955143 NCBI chr  X:74,916,548...75,062,880
Ensembl chr  X:74,916,548...75,062,880
JBrowse link
G Avp arginine vasopressin decreases expression
increases secretion
ISO
EXP
Nicotine results in decreased expression of AVP mRNA
Nicotine results in increased secretion of AVP protein alternative form
CTD PMID:3681699 PMID:17456735 PMID:28555334 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
JBrowse link
G Axin1 axin 1 multiple interactions ISO [Nicotine co-treated with nuciferine] results in increased expression of AXIN1 protein CTD PMID:25698245 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092
JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Nicotine results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:136,697,981...136,707,783
Ensembl chr 5:136,697,981...136,710,422
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
decreases phosphorylation
ISO
EXP
Nicotine results in decreased expression of BAD mRNA
Nicotine results in decreased phosphorylation of BAD protein
CTD PMID:18247414 PMID:20447445 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
JBrowse link
G Bap1 BRCA1 associated deubiquitinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA] CTD PMID:20230807 NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,452,974...6,461,952
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases phosphorylation
decreases expression
increases expression
multiple interactions
affects localization
ISO
EXP
Nicotine results in increased phosphorylation of BAX protein
Nicotine results in decreased expression of BAX protein
Nicotine results in increased expression of BAX protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of BAX protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]; IGF1 protein inhibits the reaction [Nicotine results in increased expression of BAX protein]
Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein
Nicotine affects the localization of BAX protein
Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein
3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; nuciferine inhibits the reaction [Nicotine results in decreased expression of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
CTD PMID:15831280 PMID:17135361 PMID:17525161 PMID:18203686 PMID:18676776 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Nicotine results in increased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:179,554,754...179,637,800
Ensembl chr 3:179,551,704...179,637,743
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression ISO Nicotine results in increased expression of BCL11B mRNA CTD PMID:21955143 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:132,598,968...132,691,301
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
increases phosphorylation
ISO
EXP
3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]; nuciferine inhibits the reaction [Nicotine results in increased expression of BCL2 protein]
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]
Nicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 protein
Nicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified form
CTD PMID:12421819 PMID:15831280 PMID:18448488 PMID:18676776 PMID:20061081 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Nicotine results in decreased expression of BCL2A1 mRNA CTD PMID:18247414 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of BCL2L1 mRNA
Nicotine results in decreased expression of BCL2L1 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of BCL2L1 mRNA]
CTD PMID:22687363 PMID:38229321 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bcl2l10 Bcl2-like 10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2L10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2L10 mRNA] CTD PMID:20230807 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:84,987,833...84,993,872
JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
multiple interactions
increases expression
affects expression
increases secretion
ISO
EXP
BDNF gene polymorphism affects the susceptibility to Nicotine
[Nicotine co-treated with Quartz] results in increased expression of BDNF protein
Nicotine results in increased expression of BDNF mRNA
Nicotine affects the expression of BDNF mRNA
Nicotine results in increased secretion of BDNF protein
methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein]
CTD PMID:9503263 PMID:9832142 PMID:16790237 PMID:17186223 PMID:20426880 More... NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of BECN1 mRNA
Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
CTD PMID:30605750 PMID:31926917 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of BGLAP
Nicotine results in decreased expression of BGLAP mRNA; Nicotine results in decreased expression of BGLAP protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
CTD PMID:19436947 PMID:29981921 PMID:39207236 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]
CTD PMID:20727180 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]
Nicotine results in increased expression of BIRC5 mRNA; Nicotine results in increased expression of BIRC5 protein
CTD PMID:16601104 PMID:19896492 PMID:20727180 PMID:21267677 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
multiple interactions
ISO Nicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 protein
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]
CTD PMID:23219715 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nicotine results in decreased expression of BMP4 mRNA CTD PMID:20339300 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA CTD PMID:33091441 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Nicotine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Nicotine results in decreased expression of BRAF mRNA; Nicotine results in decreased expression of BRAF protein CTD PMID:17135361 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO Nicotine results in decreased expression of BRCA1 mRNA
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]
CTD PMID:18247414 PMID:23907605 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763
JBrowse link
G Brd2 bromodomain containing 2 increases expression ISO Nicotine results in increased expression of BRD2 mRNA CTD PMID:33640489 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of BST2 mRNA CTD PMID:37951547 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO Nicotine results in decreased expression of BTF3 mRNA CTD PMID:18247414 NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Nicotine results in increased expression of BTG2 mRNA CTD PMID:17456735 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690
JBrowse link
G Btk Bruton tyrosine kinase decreases expression ISO Nicotine results in decreased expression of BTK mRNA CTD PMID:18247414 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:102,016,074...102,055,143
JBrowse link
G C1r complement C1r multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:159,098,918...159,109,714
JBrowse link
G C1s complement C1s multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736
JBrowse link
G C3ar1 complement C3a receptor 1 increases expression ISO Nicotine results in increased expression of C3AR1 mRNA CTD PMID:23825647 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO Nicotine results in decreased expression of C5AR1 mRNA CTD PMID:18247414 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C7 complement C7 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] CTD PMID:16949557 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Nicotine results in decreased expression of CAR3 mRNA CTD PMID:27782041 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression ISO Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F increases expression ISO Nicotine results in increased expression of CACNA1F mRNA CTD PMID:11756415 NCBI chr  X:17,539,992...17,568,308
Ensembl chr  X:17,539,920...17,568,308
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP Nicotine results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Nicotine results in increased expression of CACNA2D1 protein CTD PMID:11756415 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP Nicotine results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:93,152,558...93,165,246
Ensembl chr10:93,152,248...93,165,417
JBrowse link
G Cadm3 cell adhesion molecule 3 increases expression EXP Nicotine results in increased expression of CADM3 mRNA CTD PMID:27782041 NCBI chr13:88,317,124...88,349,718
Ensembl chr13:88,317,124...88,350,114
JBrowse link
G Calb1 calbindin 1 increases expression
multiple interactions
EXP Nicotine results in increased expression of CALB1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of CALB1 protein]
CTD PMID:11226671 NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of CALCRL protein CTD PMID:19910445 NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CALM1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381
JBrowse link
G Calr calreticulin increases expression ISO Nicotine results in increased expression of CALR mRNA CTD PMID:16949557 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO Nicotine results in increased expression of CAMK2A mRNA CTD PMID:21955143 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Nicotine results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Nicotine results in increased expression of CAMP mRNA CTD PMID:23825647 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:118,720,184...118,721,998
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Nicotine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:140,427,269...140,453,470
JBrowse link
G Capn10 calpain 10 increases expression ISO Nicotine results in increased expression of CAPN10 mRNA CTD PMID:17997037 NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:100,945,551...100,957,912
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 increases expression ISO Nicotine results in increased expression of CAPZA2 mRNA CTD PMID:16949557 NCBI chr 4:46,944,040...46,979,930
Ensembl chr 4:46,895,701...46,979,938
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP
ISO
Nicotine results in decreased expression of CARTPT protein
Nicotine results in decreased expression of CARTPT mRNA
CTD PMID:18247414 PMID:23623838 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO
EXP
CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein]; Nicotine results in increased expression of and results in increased cleavage of CASP1 protein
Nicotine results in increased expression of CASP1 mRNA
Nicotine results in increased expression of CASP1 protein
CTD PMID:16927020 PMID:35131329 PMID:39098741 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP12 mRNA]
Nicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]
CTD PMID:18477628 PMID:20230807 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
JBrowse link
G Casp14 caspase 14 increases expression ISO Nicotine results in increased expression of CASP14 mRNA CTD PMID:23825647 NCBI chr 7:11,577,315...11,583,987
Ensembl chr 7:11,580,339...11,583,171
JBrowse link
G Casp2 caspase 2 affects expression EXP Nicotine affects the expression of CASP2 mRNA CTD PMID:20426880 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
affects expression
decreases expression
decreases activity
ISO
EXP
geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Nicotine results in increased cleavage of CASP3 protein
Nicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative form
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein
Nicotine affects the expression of CASP3 mRNA
[Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
Nicotine results in decreased activity of CASP3 protein
CTD PMID:11701223 PMID:12115584 PMID:12218695 PMID:15831280 PMID:16237857 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 affects expression EXP Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
Nicotine results in increased expression of CASP9 protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of CASP9 protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein]
Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]
Nicotine results in decreased expression of CASP9 mRNA
CTD PMID:16949557 PMID:18676776 PMID:20230807 PMID:29972271 PMID:38229321 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP
ISO
[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
Nicotine results in increased activity of CAT protein
CTD PMID:10509436 PMID:10874619 PMID:10906423 PMID:11747978 PMID:15925865 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cav2 caveolin 2 decreases expression ISO Nicotine results in decreased expression of CAV2 mRNA CTD PMID:33640489 NCBI chr 4:46,582,681...46,590,058
Ensembl chr 4:46,582,096...46,591,425
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO Nicotine results in increased expression of CBL mRNA CTD PMID:18247414 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067
JBrowse link
G Cbln1 cerebellin 1 precursor increases expression ISO Nicotine results in increased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:35,782,151...35,785,960
Ensembl chr19:35,781,952...35,785,960
JBrowse link
G Cbx3 chromobox 3 increases expression ISO Nicotine results in increased expression of CBX3 mRNA CTD PMID:16949557 NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:81,876,649...81,889,911
JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:136,211,649...136,229,118
JBrowse link
G Ccdc136 coiled-coil domain containing 136 increases expression ISO Nicotine results in increased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:58,963,196...58,992,962
Ensembl chr 4:58,962,908...58,992,975
JBrowse link
G Ccdc159 coiled-coil domain containing 159 increases expression ISO Nicotine results in increased expression of CCDC159 mRNA CTD PMID:23825647 NCBI chr 8:28,733,988...28,742,646
Ensembl chr 8:28,725,003...28,744,890
JBrowse link
G Ccdc167 coiled-coil domain containing 167 increases expression ISO Nicotine results in increased expression of CCDC167 mRNA CTD PMID:23825647 NCBI chr20:7,768,425...7,783,181
Ensembl chr20:7,753,072...7,783,181
JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO Nicotine results in increased expression of CCDC88A mRNA CTD PMID:17456735 NCBI chr14:107,304,654...107,456,104
Ensembl chr14:107,305,199...107,453,285
JBrowse link
G Cck cholecystokinin decreases expression ISO Nicotine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein
Nicotine results in decreased secretion of CCL2 protein
Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
CTD PMID:15135227 PMID:15976189 PMID:22093924 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Nicotine results in increased expression of CCL5 mRNA CTD PMID:18247414 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Nicotine results in increased expression of CCN1 mRNA CTD PMID:17456735 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Nicotine results in increased expression of CCN2 protein CTD PMID:22691361 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Nicotine results in increased expression of CCN5 mRNA CTD PMID:23825647 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:172,910,681...172,922,062
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Nicotine results in increased expression of CCNA2 protein CTD PMID:18448488 PMID:20106947 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CCNB1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA]
CTD PMID:20106947 PMID:20230807 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases activity
ISO
EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]
Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein
Nicotine results in increased activity of CCND1 promoter
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]
Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein
CTD PMID:15574422 PMID:15983034 PMID:17135361 PMID:18448488 PMID:18805435 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]
Nicotine results in decreased expression of CCND2 protein
CTD PMID:15231866 PMID:20230807 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Nicotine results in increased expression of CCNG2 mRNA CTD PMID:23416264 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206
JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:171,699,689...171,711,231
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Nicotine results in decreased expression of CCR6 mRNA CTD PMID:18247414 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Nicotine results in increased expression of CCS protein CTD PMID:16627626 NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260
JBrowse link
G Cd151 CD151 molecule (Raph blood group) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD151 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CD151 mRNA] CTD PMID:20230807 NCBI chr 1:205,994,300...205,998,307
Ensembl chr 1:205,994,738...205,998,784
JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Nicotine results in decreased expression of CD4 mRNA CTD PMID:18247414 NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA] CTD PMID:20230807 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424
JBrowse link
G Cd46 CD46 molecule increases expression ISO Nicotine results in increased expression of CD46 mRNA CTD PMID:16949557 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Cd59b CD59b molecule increases expression ISO Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:110,914,091...110,935,310
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540
JBrowse link
G Cd86 CD86 molecule increases expression EXP Nicotine results in increased expression of CD86 mRNA CTD PMID:27782041 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361
JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA] CTD PMID:20230807 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] CTD PMID:16862215 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA] CTD PMID:20230807 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]
[Nicotine co-treated with Quartz] results in increased expression of CDH1 protein
Nicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 protein
CTD PMID:18844224 PMID:20061081 PMID:23219715 PMID:36868510 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO [Nicotine co-treated with Quartz] results in increased expression of CDH2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of CDH2 protein] CTD PMID:36868510 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CDK1 protein
CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]
CTD PMID:35929799 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO Nicotine results in increased expression of CDK13 mRNA CTD PMID:16949557 NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] CTD PMID:35929799 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
Nicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 protein
CTD PMID:15231866 PMID:17135361 PMID:18805435 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]
Nicotine results in increased expression of CDK6 mRNA
CTD PMID:16949557 PMID:18805435 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]
Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]
CTD PMID:16011614 PMID:16601104 PMID:18805435 PMID:20727180 PMID:30272249 More... NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Nicotine results in decreased expression of CDKN1B protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]; Nicotine results in increased expression of and results in increased stability of CDKN1B protein
CTD PMID:15231866 PMID:18805435 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]
Nicotine results in increased expression of CDKN2A mRNA; Nicotine results in increased expression of CDKN2A protein
CTD PMID:32473187 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases splicing ISO Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 NCBI chr14:8,126,678...8,187,243
Ensembl chr14:8,124,838...8,187,218
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
affects expression
increases expression
EXP
ISO
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein
Nicotine affects the expression of CEBPA mRNA
Nicotine results in increased expression of CEBPA mRNA
CTD PMID:29617909 PMID:31622651 PMID:31972234 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CEBPB mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA
CTD PMID:18805435 PMID:29617909 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression EXP Nicotine results in increased expression of CELF6 mRNA CTD PMID:27782041 NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:68,871,093...68,901,863
JBrowse link
G Cenpe centromere protein E increases expression ISO Nicotine results in increased expression of CENPE mRNA CTD PMID:16949557 NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:226,300,798...226,369,636
JBrowse link
G Cers6 ceramide synthase 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA CTD PMID:28065790 NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544
JBrowse link
G Cetn2 centrin 2 decreases expression ISO Nicotine results in decreased expression of CETN2 mRNA CTD PMID:17997037 NCBI chr  X:155,812,212...155,817,186
Ensembl chr  X:155,812,003...155,817,744
JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:13,817,760...13,837,502
Ensembl chr 2:13,824,803...13,837,502
JBrowse link
G Cfap43 cilia and flagella associated protein 43 decreases expression ISO Nicotine results in decreased expression of CFAP43 mRNA CTD PMID:23825647 NCBI chr 1:256,566,558...256,653,816
Ensembl chr 1:256,566,559...256,653,840
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression ISO Nicotine results in increased expression of CGA mRNA CTD PMID:23825647 NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:54,235,019...54,295,464
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression ISO Nicotine results in increased expression of CGREF1 mRNA CTD PMID:23825647 NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:31,151,795...31,163,800
JBrowse link
G Chat choline O-acetyltransferase multiple interactions
increases activity
decreases activity
EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]
Nicotine results in increased activity of CHAT protein
Nicotine results in decreased activity of CHAT protein
CTD PMID:20361958 PMID:21633116 PMID:22119111 PMID:30247698 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Nicotine results in increased expression of CHD2 mRNA CTD PMID:16949557 NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:136,599,900...136,710,335
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667
JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression
ISO
EXP
CHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]
Nicotine results in increased expression of CHGA mRNA
CTD PMID:1907749 PMID:12799369 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:127,460,854...127,472,237
JBrowse link
G Chgb chromogranin B increases expression EXP Nicotine results in increased expression of CHGB mRNA; Nicotine results in increased expression of CHGB protein CTD PMID:1907749 NCBI chr 3:140,496,712...140,510,057
Ensembl chr 3:140,495,951...140,510,054
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions
affects binding
ISO PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein] CTD PMID:19690163 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:78,862,286...78,877,353
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit increases expression EXP Nicotine results in increased expression of CHRNA10 mRNA CTD PMID:30959089 PMID:31846720 NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:165,899,261...165,903,458
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit affects response to substance
multiple interactions
ISO CHRNA2 gene mutant form affects the susceptibility to Nicotine
Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
CTD PMID:9454827 PMID:19383498 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:44,517,862...44,534,144
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression
increases activity
multiple interactions
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA3 mRNA
Nicotine results in increased activity of CHRNA3 protein
Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
Nicotine results in increased expression of CHRNA3 mRNA
CHRNA3 protein affects the susceptibility to Nicotine
CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
CTD PMID:9454827 PMID:10336510 PMID:11600638 PMID:12628473 PMID:15275829 More... NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
increases expression
decreases expression
multiple interactions
increases response to substance
affects response to substance
ISO
EXP
Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 protein
Nicotine results in decreased expression of CHRNA4 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CHRNA4 protein mutant form results in increased susceptibility to Nicotine
CHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to Nicotine
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD PMID:7756618 PMID:9336329 PMID:9454827 PMID:10336510 PMID:10377228 More... NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit increases response to substance
increases expression
affects response to substance
decreases expression
multiple interactions
ISO CHRNA5 gene polymorphism results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA
CHRNA5 gene polymorphism affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA; Nicotine results in increased expression of CHRNA5 protein
Nicotine results in decreased expression of CHRNA5 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]
CTD PMID:9495872 PMID:12628473 PMID:18450646 PMID:18519132 PMID:24793809 More... NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:64,265,879...64,294,233
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression
increases expression
multiple interactions
affects response to substance
ISO Nicotine results in decreased expression of CHRNA6 mRNA
Nicotine results in increased expression of CHRNA6 mRNA
Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]
CHRNA6 gene polymorphism affects the susceptibility to Nicotine
CTD PMID:10734154 PMID:12628473 PMID:17227438 PMID:29293602 PMID:30959089 NCBI chr16:71,400,615...71,407,315
Ensembl chr16:71,400,615...71,407,315
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
increases expression
affects activity
increases activity
decreases expression
multiple interactions
affects response to substance
ISO
EXP
CHRNA7 protein mutant form results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine affects the activity of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein
Nicotine results in decreased expression of CHRNA7 mRNA; Nicotine results in decreased expression of CHRNA7 protein
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Nicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein
[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine
CHRNA7 gene polymorphism affects the susceptibility to Nicotine; CHRNA7 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7; Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein; Nicotine results in increased activity of CHRNA7 protein mutant form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]; Nicotine binds to and results in increased activity of CHRNA7 protein; Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein; Pyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]
CTD PMID:9336329 PMID:9495872 PMID:10082212 PMID:10216184 PMID:10942032 More... NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit increases expression
multiple interactions
ISO Nicotine results in increased expression of CHRNA9 mRNA
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein
CTD PMID:29486207 PMID:30259641 PMID:30959089 PMID:31846720 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,588,948...42,595,669
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression
decreases expression
affects binding
affects response to substance
ISO
EXP
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in decreased expression of CHRNB2 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA; Nicotine results in increased expression of CHRNB2 protein
CHRNB2 protein affects the susceptibility to Nicotine
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD PMID:7756618 PMID:9336329 PMID:10336510 PMID:10377228 PMID:10945867 More... NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression EXP Nicotine results in increased expression of CHRNB3 mRNA CTD PMID:30959089 NCBI chr16:71,411,847...71,454,225
Ensembl chr16:71,417,039...71,454,225
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions
increases expression
increases activity
affects response to substance
ISO
EXP
Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
Nicotine results in increased expression of CHRNB4 mRNA
Nicotine results in increased activity of CHRNB4 protein
Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CHRNB4 protein affects the susceptibility to Nicotine
CTD PMID:9454827 PMID:11600638 PMID:15275829 PMID:15615518 PMID:19483072 More... NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Nicotine results in decreased expression of CIAO1 mRNA CTD PMID:11478936 NCBI chr 3:134,913,639...134,919,244
Ensembl chr 3:134,913,172...134,979,255
JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CIB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CIB1 mRNA] CTD PMID:20230807 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:143,587,021...143,593,326
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Nicotine results in decreased expression of CIDEA mRNA CTD PMID:33091441 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Nicotine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:10,184,515...10,189,623 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CKMT1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:128,783,597...128,789,483
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression ISO Nicotine results in decreased expression of CKMT2 mRNA CTD PMID:16949557 NCBI chr 2:24,815,008...24,845,511
Ensembl chr 2:24,815,008...24,845,511
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO Nicotine results in decreased expression of CKS1B mRNA CTD PMID:18247414 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:177,130,777...177,135,365
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO Nicotine results in increased expression of CKS2 mRNA CTD PMID:16949557 NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CLCA2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLCA2 mRNA] CTD PMID:20230807 NCBI chr 2:236,655,419...236,682,669
Ensembl chr 2:236,639,545...236,685,129
JBrowse link
G Clcc1 chloride channel CLIC-like 1 increases expression ISO Nicotine results in increased expression of CLCC1 mRNA CTD PMID:16949557 NCBI chr 2:198,984,455...199,015,015
Ensembl chr 2:198,984,495...199,015,014
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Nicotine results in increased expression of CLCN3 mRNA CTD PMID:16949557 NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984
JBrowse link
G Cldn4 claudin 4 increases expression
decreases expression
ISO Nicotine results in increased expression of CLDN4 protein
Nicotine results in decreased expression of CLDN4 protein
CTD PMID:31783125 NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Nicotine results in decreased expression of CLIC1 mRNA CTD PMID:16949557 NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367
JBrowse link
G Clmp CXADR-like membrane protein increases expression ISO Nicotine results in increased expression of CLMP mRNA CTD PMID:23825647 NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:49,957,720...50,065,959
JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:165,314,128...165,377,627
Ensembl chr 5:165,314,309...165,377,625
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 decreases expression ISO Nicotine results in decreased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:32,382,171...32,385,288
Ensembl chr15:32,382,608...32,385,271
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:10,363,102...10,370,312
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance
increases expression
multiple interactions
ISO CNR1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CNR1 mRNA
[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine
CTD PMID:12384171 PMID:16416159 PMID:21955143 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
JBrowse link
G Cntn1 contactin 1 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of CNTN1 mRNA
Nicotine results in increased expression of CNTN1 mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
CTD PMID:12588870 PMID:16949557 NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:125,142,696...125,440,391
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
increases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Nicotine promotes the reaction [Thioacetamide results in increased expression of COL1A1]
Nicotine results in decreased expression of COL1A1 mRNA; Nicotine results in decreased expression of COL1A1 protein
Nicotine results in increased expression of COL1A1 mRNA; Nicotine results in increased expression of COL1A1 protein
CTD PMID:20230807 PMID:28440100 PMID:33082140 PMID:33640489 PMID:34153408 More... NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP
ISO
Nicotine promotes the reaction [Arginine results in increased expression of COL1A2 protein]
Nicotine promotes the reaction [Quartz results in increased expression of COL1A2 protein]
CTD PMID:34153408 PMID:36868510 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of COL2A1 mRNA; Nicotine results in decreased expression of COL2A1 protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of COL3A1 mRNA
Nicotine results in increased expression of COL3A1 mRNA; Nicotine results in increased expression of COL3A1 protein
Nicotine promotes the reaction [Arginine results in increased expression of COL3A1 protein]
NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]
CTD PMID:33082140 PMID:34153408 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL6A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL6A1 mRNA] CTD PMID:20230807 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107
JBrowse link
G Cort cortistatin affects expression
decreases expression
EXP Nicotine affects the expression of CORT protein
Nicotine results in decreased expression of CORT protein
CTD PMID:22975262 PMID:26776438 PMID:28555334 NCBI chr 5:164,843,682...164,845,796 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of COX7A2L mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:16,936,795...16,950,798
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:18,577,145...18,579,170
Ensembl chr 2:18,577,149...18,579,170
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO Nicotine results in decreased expression of CRABP2 mRNA CTD PMID:16949557 NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:175,707,312...175,728,385
JBrowse link
G Crct1 cysteine-rich C-terminal 1 increases expression ISO Nicotine results in increased expression of CRCT1 mRNA CTD PMID:23825647 NCBI chr 2:181,329,392...181,330,877
Ensembl chr 2:181,329,392...181,330,877
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
increases phosphorylation
decreases expression
ISO
EXP
CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of CREB1 mRNA
Nicotine results in increased phosphorylation of CREB1 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]; Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nicotine results in decreased expression of CREB1 mRNA
CTD PMID:18247414 PMID:21113126 PMID:25847246 PMID:31945395 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Nicotine results in increased expression of CREB3 mRNA CTD PMID:31945395 NCBI chr 5:62,613,652...62,619,019
Ensembl chr 5:62,613,638...62,619,500
JBrowse link
G Creb5 cAMP responsive element binding protein 5 increases expression ISO Nicotine results in increased expression of CREB5 mRNA CTD PMID:31945395 NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:83,723,194...84,120,793
JBrowse link
G Crebbp CREB binding protein increases expression ISO Nicotine results in increased expression of CREBBP mRNA CTD PMID:31945395 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266
JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of CRH mRNA; Nicotine results in decreased expression of CRH protein
Nicotine results in increased expression of CRH protein
CTD PMID:21955143 PMID:22265867 PMID:23623838 PMID:28555334 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Nicotine results in decreased expression of CRYAB mRNA CTD PMID:21955143 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528
JBrowse link
G Cs citrate synthase multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA CTD PMID:33091441 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Nicotine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:115,332,128...115,346,596
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
ISO Nicotine results in increased expression of and results in increased secretion of CSF2 protein; Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 PMID:18082304 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Csn2 casein beta multiple interactions ISO Nicotine results in decreased expression of and results in decreased secretion of CSN2 protein CTD PMID:31783125 NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,601,824...20,609,060
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CSNK2A1 protein
CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]
CTD PMID:35929799 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CST3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of CTNNB1 mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
Nicotine results in increased expression of CTNNB1 protein
nuciferine inhibits the reaction [Nicotine results in increased expression of CTNNB1 protein]
Nicotine results in increased expression of CTNNB1 mRNA; Nicotine results in increased expression of CTNNB1 protein
CTD PMID:25698245 PMID:33640489 PMID:35411647 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] CTD PMID:20230807 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
JBrowse link
G Ctsh cathepsin H increases expression ISO Nicotine results in increased expression of CTSH mRNA CTD PMID:23825647 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CTSL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Nicotine results in decreased expression of CXCL2 mRNA CTD PMID:18247414 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion
increases expression
ISO Nicotine results in decreased expression of CXCL1 mRNA
Nicotine results in decreased secretion of CXCL1 protein
Nicotine results in increased expression of CXCL1 protein
CTD PMID:16254210 PMID:22093924 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression
increases expression
ISO Nicotine results in decreased expression of CXCR2 mRNA
Nicotine results in increased expression of CXCR2 mRNA
CTD PMID:18247414 PMID:20457658 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Nicotine results in increased expression of CXCR3 mRNA CTD PMID:20457658 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:70,883,958...70,886,871
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
increases expression
ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]
Nicotine results in increased expression of CXCR4 mRNA; Nicotine results in increased expression of CXCR4 protein
CTD PMID:20457658 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
increases secretion
affects localization
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]
Nicotine results in increased expression of CYCS protein
Nicotine results in increased secretion of CYCS protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein]
Nicotine affects the localization of CYCS protein
Nicotine results in decreased secretion of CYCS protein
CTD PMID:11701223 PMID:15985439 PMID:18203686 PMID:29972271 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
decreases activity
multiple interactions
ISO
EXP
Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein
Nicotine results in decreased activity of CYP11A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]
CTD PMID:20230807 PMID:21971485 PMID:22265867 PMID:24709674 PMID:28986172 More... NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Nicotine results in decreased expression of CYP11B1 mRNA CTD PMID:24709674 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO
EXP
Nicotine results in decreased expression of CYP17A1 mRNA
Nicotine results in decreased expression of CYP17A1 mRNA; Nicotine results in decreased expression of CYP17A1 protein
CTD PMID:24709674 PMID:27782041 PMID:28986172 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases activity
ISO
EXP
Nicotine results in decreased expression of CYP19A1 mRNA; Nicotine results in decreased expression of CYP19A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP19A1 protein]
Nicotine results in increased activity of CYP19A1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]
CTD PMID:30959089 PMID:32113805 PMID:35577041 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CYP1A1 mRNA; Nicotine results in increased expression of CYP1A1 protein
Nicotine results in decreased expression of CYP1A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1A1 protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SR 11302 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]
CTD PMID:11849738 PMID:22498344 PMID:34171359 PMID:35577041 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
decreases activity
ISO
EXP
Nicotine results in increased expression of CYP1A2 protein
Nicotine results in decreased expression of CYP1A2 mRNA
Nicotine results in decreased activity of CYP1A2 protein
CTD PMID:11849738 PMID:15916432 PMID:26463278 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of CYP1B1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1B1 protein]
CTD PMID:35577041 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Nicotine results in decreased expression of CYP26A1 mRNA; Nicotine results in decreased expression of CYP26A1 protein CTD PMID:21371177 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
increases hydroxylation
multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
Nicotine results in increased expression of CYP2A1 mRNA
CYP2A6 protein results in increased hydroxylation of Nicotine
Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]
Nicotine results in decreased activity of CYP2A13 protein
CYP2A13 protein results in increased metabolism of Nicotine
CTD PMID:12919726 PMID:22743290 PMID:22934830 PMID:27567546 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression EXP Nicotine results in increased expression of CYP2A2 mRNA CTD PMID:22934830 NCBI chr 1:91,391,492...91,417,158
Ensembl chr 1:91,391,502...91,417,158
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Nicotine results in increased expression of CYP2A3 mRNA CTD PMID:14972772 PMID:22934830 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
increases metabolic processing
EXP [Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP2B1 mRNA; [Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine; [Nicotine results in increased expression of CYP2B1 protein] which results in increased metabolism of Nicotine; Nicotine results in increased expression of and results in increased activity of CYP2B1 protein
Nicotine results in increased expression of CYP2B1 mRNA; Nicotine results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of Nicotine
CTD PMID:10799646 PMID:14972772 PMID:20599831 PMID:26463278 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing
increases oxidation
affects oxidation
multiple interactions
ISO CYP2B6 protein results in increased metabolism of Nicotine
CYP2B6 protein results in increased oxidation of Nicotine
CYP2B6 gene polymorphism affects the oxidation of Nicotine
CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine]
CTD PMID:12488541 PMID:18004205 PMID:30906561 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases expression
ISO Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]
Nicotine results in increased expression of CYP2D22 mRNA; Nicotine results in increased expression of CYP2D22 protein
CTD PMID:19594327 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nicotine results in increased expression of CYP2E1 protein CTD PMID:16434548 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP3A2 mRNA
[Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA
CTD PMID:12851153 PMID:26463278 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Nicotine results in increased expression of CYP4F3 mRNA CTD PMID:23825647 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] CTD PMID:17498763 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316
JBrowse link
G Dcaf16 DDB1 and CUL4 associated factor 16 increases expression ISO Nicotine results in increased expression of DCAF16 mRNA CTD PMID:16949557 NCBI chr14:69,662,173...69,662,557 JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Nicotine results in decreased expression of DDB1 mRNA CTD PMID:16949557 NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:216,677,810...216,703,596
JBrowse link
G Ddhd2 DDHD domain containing 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA CTD PMID:28065790 NCBI chr16:73,022,136...73,051,746
Ensembl chr16:73,022,193...73,051,745
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]
CTD PMID:11592233 PMID:28082123 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Nicotine results in increased expression of DDIT4 mRNA CTD PMID:17456735 PMID:23825647 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO Nicotine results in increased expression of DDX17 mRNA CTD PMID:16949557 NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747
JBrowse link
G Dedd death effector domain-containing decreases expression ISO Nicotine results in decreased expression of DEDD mRNA CTD PMID:18247414 NCBI chr13:86,286,341...86,301,789
Ensembl chr13:86,288,350...86,302,446
JBrowse link
G Defb23 defensin beta 23 decreases expression ISO Nicotine results in decreased expression of DEFB129 mRNA CTD PMID:23825647 NCBI chr 3:161,383,615...161,390,685
Ensembl chr 3:161,383,319...161,388,004
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO Nicotine results in decreased expression of DFFB mRNA CTD PMID:18247414 NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Nicotine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Dhps deoxyhypusine synthase decreases expression ISO Nicotine results in decreased expression of DHPS mRNA CTD PMID:16949557 NCBI chr19:39,987,328...39,991,418
Ensembl chr19:39,987,324...39,991,432
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Nicotine results in increased expression of DHRS3 mRNA CTD PMID:23825647 NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:162,031,386...162,065,653
JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Nicotine results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:149,006,089...149,044,191
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
decreases methylation
ISO
EXP
Nicotine results in decreased expression of DLG4 mRNA
Nicotine results in decreased methylation of DLG4 gene
CTD PMID:21955143 PMID:28555334 PMID:32994467 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJB9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal decreases expression ISO Nicotine results in decreased expression of DNASE2 mRNA CTD PMID:18247414 NCBI chr19:40,149,505...40,152,225
Ensembl chr19:40,149,505...40,152,225
JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Nicotine results in increased expression of DNM1L protein CTD PMID:21554491 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of DNMT1 mRNA
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]
CTD PMID:28555334 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
EXP
ISO
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in decreased expression of DRD1 mRNA
CTD PMID:1833784 PMID:21955143 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases response to substance
EXP [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine
DRD2 mRNA results in decreased susceptibility to Nicotine
CTD PMID:1833784 PMID:24239691 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd3 dopamine receptor D3 increases expression ISO Nicotine results in increased expression of DRD3 protein CTD PMID:31945395 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression ISO Nicotine results in decreased expression of DTYMK mRNA CTD PMID:16949557 NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:101,762,899...101,774,504
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Nicotine results in increased expression of DUSP1 mRNA CTD PMID:17456735 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Nicotine results in decreased expression of DUSP11 mRNA CTD PMID:17456735 NCBI chr 4:119,928,533...119,942,643
Ensembl chr 4:119,928,537...119,942,567
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Nicotine results in increased expression of DUSP6 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of DVL2 mRNA
Nicotine results in increased expression of DVL2 mRNA; Nicotine results in increased expression of DVL2 protein
Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 protein]
CTD PMID:16949557 PMID:33640489 PMID:35411647 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:55,222,056...55,231,506
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Nicotine results in increased expression of DYNC1LI2 mRNA CTD PMID:16949557 NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] CTD PMID:16601104 PMID:16862215 PMID:20061081 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions ISO Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087
JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834
JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression EXP Nicotine results in increased expression of EBF2 mRNA CTD PMID:35026373 NCBI chr15:45,610,949...45,809,828
Ensembl chr15:45,610,949...45,809,822
JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ECM1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
ISO MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]
Nicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 protein
CTD PMID:33082140 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Nicotine results in decreased expression of EDNRA mRNA CTD PMID:18247414 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284
JBrowse link
G Ednrb endothelin receptor type B increases activity EXP Nicotine results in increased activity of EDNRB protein CTD PMID:21316381 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of EEF2 protein modified form
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Nicotine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798
JBrowse link
G Efna2 ephrin A2 increases expression ISO Nicotine results in increased expression of EFNA2 mRNA CTD PMID:23825647 NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:10,167,091...10,177,719
JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EFNB3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,773,282...54,797,651
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in decreased expression of EGFR mRNA
Nicotine results in increased phosphorylation of EGFR protein
AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein]
CTD PMID:11478936 PMID:14569062 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein
Nicotine results in decreased expression of EGR1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA]
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]
CTD PMID:17456735 PMID:17997037 PMID:20230807 PMID:21955143 PMID:22198237 More... NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Egr2 early growth response 2 increases expression ISO Nicotine results in increased expression of EGR2 mRNA CTD PMID:17456735 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748
JBrowse link
G Egr3 early growth response 3 decreases expression ISO Nicotine results in decreased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression ISO Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF2B4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF2B4 mRNA] CTD PMID:20230807 NCBI chr 6:30,903,148...30,908,803
Ensembl chr 6:30,903,219...30,908,800
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Nicotine results in increased phosphorylation of EIF2S1 protein CTD PMID:26803847 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]
EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]
CTD PMID:20230807 PMID:30836163 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105
JBrowse link
G Eif4e3 eukaryotic translation initiation factor 4E family member 3 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of EIF4E3 mRNA CTD PMID:37951547 NCBI chr 4:133,709,802...133,858,398
Ensembl chr 4:133,625,768...133,885,647
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]; Nicotine results in increased expression of and results in increased phosphorylation of EIF4EBP1 protein CTD PMID:12511591 PMID:30836163 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821
JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in increased phosphorylation of ELK1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]
CTD PMID:29486207 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249
JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Nicotine results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:148,217,395...148,234,595
JBrowse link
G Emcn endomucin increases expression ISO Nicotine results in increased expression of EMCN mRNA CTD PMID:17456735 NCBI chr 2:228,564,445...228,644,370
Ensembl chr 2:228,564,430...228,645,155
JBrowse link
G Eml4 EMAP like 4 multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Nicotine results in increased expression of EMP1 mRNA CTD PMID:23825647 NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Nicotine results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721
JBrowse link
G Eng endoglin decreases expression ISO Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Nicotine results in increased expression of ENTPD3 mRNA CTD PMID:23825647 NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:129,124,709...129,156,252
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO Nicotine results in decreased expression of EPHA3 mRNA CTD PMID:18247414 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425
JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Nicotine results in decreased expression of EPHB3 mRNA CTD PMID:18247414 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775
JBrowse link
G Epo erythropoietin increases expression ISO Nicotine results in increased expression of EPO mRNA CTD PMID:18247414 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ERP44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:67,312,098...67,406,444
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO Nicotine results in increased expression of ERRFI1 mRNA CTD PMID:17456735 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Nicotine results in decreased expression of ESR1 mRNA CTD PMID:27552315 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ETFA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ETFA mRNA] CTD PMID:20230807 NCBI chr 8:64,731,192...64,787,965
Ensembl chr 8:64,731,193...64,788,080
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Nicotine results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:102,988,499...103,002,659
JBrowse link
G Ezr ezrin multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]
Nicotine results in increased expression of EZR mRNA
CTD PMID:18247414 PMID:20230807 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573
JBrowse link
G F2 coagulation factor II, thrombin increases expression ISO Nicotine results in increased expression of F2 mRNA CTD PMID:18805435 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Nicotine results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:28,706,501...28,712,473
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Nicotine results in increased expression of F3 mRNA CTD PMID:17997037 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369
JBrowse link
G Fah fumarylacetoacetate hydrolase increases expression ISO Nicotine results in increased expression of FAH mRNA CTD PMID:23825647 NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:147,957,935...147,981,046
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO Nicotine results in decreased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:19,038,726...19,060,644
Ensembl chr15:19,038,616...19,065,219
JBrowse link
G Fam120a family with sequence similarity 120 member A decreases expression ISO Nicotine results in decreased expression of FAM120A mRNA CTD PMID:17997037 NCBI chr17:15,890,151...15,981,337
Ensembl chr17:15,890,605...15,981,332
JBrowse link
G Fam83f family with sequence similarity 83, member F increases expression ISO Nicotine results in increased expression of FAM83F mRNA CTD PMID:23825647 NCBI chr 7:114,091,356...114,120,640
Ensembl chr 7:114,091,335...114,120,638
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
Nicotine results in increased expression of FAS mRNA; Nicotine results in increased expression of FAS protein CTD PMID:18203686 PMID:20383341 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Faslg Fas ligand affects expression
increases expression
EXP
ISO
Nicotine affects the expression of FASLG mRNA
Nicotine results in increased expression of FASLG mRNA; Nicotine results in increased expression of FASLG protein
Nicotine results in increased expression of FASLG protein alternative form
CTD PMID:18203686 PMID:18247414 PMID:19896492 PMID:20383341 PMID:20426880 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
JBrowse link
G Fasn fatty acid synthase increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of FASN mRNA; Nicotine results in increased expression of FASN protein
Nicotine affects the expression of FASN mRNA
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]
CTD PMID:24368177 PMID:29155039 PMID:31622651 PMID:31972234 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO Nicotine results in increased expression of FAT1 mRNA CTD PMID:16949557 NCBI chr16:53,909,759...54,029,175
Ensembl chr16:53,909,556...54,028,609
JBrowse link
G Fat2 FAT atypical cadherin 2 increases expression ISO Nicotine results in increased expression of FAT2 mRNA CTD PMID:23825647 NCBI chr10:39,864,765...39,957,027
Ensembl chr10:39,864,766...39,956,902
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Nicotine results in increased expression of FBN1 mRNA CTD PMID:17456735 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283
JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FBXL12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:27,445,823...27,457,772
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Nicotine results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:28,720,670...28,725,237
Ensembl chr 3:28,720,778...28,725,235
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of FEZ1 mRNA
alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form]; Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
CTD PMID:12588870 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:44,733,300...44,784,097
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
decreases expression
increases secretion
ISO
EXP
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]
Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]
Nicotine results in decreased expression of FGF2 protein
CTD PMID:9503263 PMID:9832142 PMID:14732461 PMID:15465631 PMID:16365874 More... NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein] CTD PMID:36868510 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Nicotine results in increased expression of FLRT2 mRNA CTD PMID:23825647 NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:120,507,689...120,609,004
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO Nicotine results in decreased expression of FLT3 mRNA CTD PMID:18247414 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Nicotine CTD PMID:12504349 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
JBrowse link
G Fn1 fibronectin 1 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of FN1 mRNA
Nicotine results in increased expression of FN1 mRNA; Nicotine results in increased expression of FN1 protein
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Nicotine promotes the reaction [Quartz results in increased expression of FN1 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]
CTD PMID:18247414 PMID:18844224 PMID:33082140 PMID:36868510 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Folr1 folate receptor alpha increases expression ISO Nicotine results in increased expression of FOLR1 mRNA CTD PMID:19616087 NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
affects expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS protein
Nicotine results in increased phosphorylation of FOS protein
Nicotine deficiency affects the expression of FOS protein
Acetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein]
Nicotine results in decreased expression of FOS mRNA
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
CTD PMID:11425648 PMID:15857624 PMID:16251992 PMID:16690037 PMID:17003101 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP
Nicotine results in increased expression of FOSB mRNA
Nicotine results in increased expression of FOSB protein
CTD PMID:16949557 PMID:17324382 PMID:17456735 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein CTD PMID:12511591 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO Nicotine results in decreased expression of FOXP1 mRNA CTD PMID:21955143 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Nicotine results in decreased expression of FOXP3 protein CTD PMID:31629012 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894
JBrowse link
G Fpr1 formyl peptide receptor 1 increases expression EXP Nicotine results in increased expression of FPR1 protein CTD PMID:39824327 NCBI chr 1:67,417,991...67,429,813
Ensembl chr 1:67,421,313...67,422,520
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Nicotine results in decreased expression of SNL mRNA CTD PMID:18247414 NCBI chr12:16,710,601...16,723,734
Ensembl chr12:16,710,601...16,723,734
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Nicotine results in decreased expression of FSHB mRNA; Nicotine results in decreased expression of FSHB protein CTD PMID:20498001 PMID:28986172 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 increases expression ISO Nicotine results in increased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:95,414,556...95,418,645
Ensembl chr 1:95,414,557...95,418,591
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Nicotine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:95,405,071...95,414,407
Ensembl chr 1:95,405,225...95,414,345
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of FYN protein CTD PMID:17709503 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Nicotine results in decreased activity of G6PD protein CTD PMID:20498001 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144
JBrowse link
G Gab1 GRB2-associated binding protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA] CTD PMID:20230807 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Nicotine results in increased expression of GABRA3 mRNA CTD PMID:28339662 NCBI chr  X:155,301,979...155,543,870
Ensembl chr  X:155,303,928...155,543,863
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases expression EXP Nicotine results in increased expression of GABRA5 mRNA CTD PMID:28339662 NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:117,404,494...117,516,635
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Nicotine results in increased expression of GABRA6 mRNA CTD PMID:28339662 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:27,311,979...27,327,234
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Nicotine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions
decreases methylation
EXP Nicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 protein
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]
Nicotine results in decreased methylation of GAD1 promoter
CTD PMID:18312583 PMID:28555334 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Nicotine results in decreased expression of GAD2 mRNA CTD PMID:28555334 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression ISO Nicotine results in decreased expression of GAL mRNA CTD PMID:21955143 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Nicotine results in decreased expression of GALE mRNA CTD PMID:16949557 NCBI chr 5:153,477,420...153,481,926
Ensembl chr 5:153,478,325...153,481,922
JBrowse link
G Galk2 galactokinase 2 increases expression ISO Nicotine results in increased expression of GALK2 mRNA CTD PMID:17456735 NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:133,563,538...133,696,528
JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein] CTD PMID:23933227 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]
Nicotine results in increased expression of GATA2 mRNA; Nicotine results in increased expression of GATA2 protein
CTD PMID:18450646 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter] CTD PMID:24089524 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]
CTD PMID:20230807 PMID:24089524 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B increases expression ISO Nicotine results in increased expression of GATAD2B mRNA CTD PMID:33640489 NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:178,046,085...178,147,315
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Nicotine results in increased expression of GCH1 mRNA CTD PMID:16949557 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA] CTD PMID:20230807 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gcm1 glial cells missing transcription factor 1 decreases expression EXP Nicotine results in decreased expression of GCM1 mRNA; Nicotine results in decreased expression of GCM1 protein CTD PMID:24368670 NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:87,805,993...87,819,229
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Nicotine results in increased expression of GCNT2 mRNA
Nicotine results in decreased expression of GCNT2 mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989
JBrowse link
G Gdf1 growth differentiation factor 1 increases expression ISO Nicotine results in increased expression of GDF1 mRNA CTD PMID:18247414 NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,131,276...19,146,480
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Nicotine results in increased expression of GEM mRNA CTD PMID:17456735 NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
ISO Nicotine results in decreased expression of GFAP mRNA
Nicotine results in increased expression of GFAP mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Ggct gamma-glutamyl cyclotransferase increases splicing ISO Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:85,453,387...85,470,224
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
EXP Nicotine results in increased activity of GGT1 protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein]
CTD PMID:31857090 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050
JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GHITM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Nicotine results in increased expression of GJA1 mRNA; Nicotine results in increased expression of GJA1 protein CTD PMID:36720419 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Nicotine results in increased expression of GJA4 mRNA CTD PMID:28087314 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216
JBrowse link
G Gjc2 gap junction protein, gamma 2 increases expression ISO Nicotine results in increased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:44,462,203...44,470,924
Ensembl chr10:44,462,054...44,470,340
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO Nicotine results in increased expression of GLIPR1 mRNA CTD PMID:16949557 NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:49,373,581...49,384,640
JBrowse link
G Gm2a ganglioside GM2 activator increases expression
increases splicing
ISO Nicotine results in increased expression of GM2A mRNA
Nicotine results in increased splicing of GM2A mRNA alternative form
CTD PMID:23825647 NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:22,549,705...22,560,125
Ensembl chr15:22,547,034...22,560,308
JBrowse link
G Gnai2 G protein subunit alpha i2 increases splicing
multiple interactions
ISO Nicotine results in increased splicing of GNAI2 mRNA alternative form
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GNAI2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GNAI2 mRNA]
CTD PMID:20230807 PMID:23825647 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622
JBrowse link
G Gng10 G protein subunit gamma 10 increases expression ISO Nicotine results in increased expression of GNG10 mRNA CTD PMID:16949557 NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:78,651,167...78,658,059
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Nicotine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,977,681...32,983,121
Ensembl chr 4:32,977,664...32,984,438
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Nicotine results in decreased expression of GNRHR mRNA CTD PMID:28986172 NCBI chr14:22,211,666...22,229,654 JBrowse link
G Golga4 golgin A4 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] CTD PMID:16949557 NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603
JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:177,064,071...177,077,165
Ensembl chr 4:177,064,073...177,077,164
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA CTD PMID:28065790 NCBI chr10:89,085,323...89,105,665
Ensembl chr10:89,086,331...89,105,637
JBrowse link
G Gpatch2 G patch domain containing 2 increases splicing ISO Nicotine results in increased splicing of GPATCH2 mRNA alternative form CTD PMID:23825647 NCBI chr13:101,316,413...101,457,109
Ensembl chr13:101,316,413...101,457,109
JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Nicotine results in increased expression of GPNMB mRNA CTD PMID:23825647 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240
JBrowse link
G Gpr50 G protein-coupled receptor 50 increases expression
increases splicing
ISO Nicotine results in increased expression of GPR50 mRNA
Nicotine results in increased splicing of GPR50 mRNA alternative form
CTD PMID:23825647 NCBI chr  X:154,413,592...154,419,236
Ensembl chr  X:154,413,689...154,418,275
JBrowse link
G Gpr6 G protein-coupled receptor 6 increases expression ISO Nicotine results in increased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:46,072,480...46,075,251
Ensembl chr20:46,072,453...46,075,875
JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP Nicotine results in increased expression of GPR83 mRNA CTD PMID:27782041 NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:19,974,993...19,985,490
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Nicotine results in increased expression of GPR88 mRNA CTD PMID:21955143 NCBI chr 2:206,876,373...206,885,034
Ensembl chr 2:206,868,585...206,884,945
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 increases expression ISO Nicotine results in increased expression of GPRASP1 mRNA CTD PMID:17456735 NCBI chr  X:103,556,493...103,564,275
Ensembl chr  X:103,501,377...103,565,649
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B increases expression ISO Nicotine results in increased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:182,748,247...182,772,711
Ensembl chr 1:182,748,247...182,772,757
JBrowse link
G Gprc5c G protein-coupled receptor, class C, group 5, member C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPRC5C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPRC5C mRNA] CTD PMID:20230807 NCBI chr10:100,385,682...100,407,953
Ensembl chr10:100,383,631...100,426,962
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO
EXP
Nicotine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
Nicotine results in increased expression of GPT protein
nuciferine inhibits the reaction [Nicotine results in increased expression of GPT protein]
dexpanthenol inhibits the reaction [Nicotine results in increased expression of GPT protein]
CTD PMID:25698245 PMID:35411647 PMID:38229321 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of GPX1 mRNA
Nicotine results in increased expression of GPX1 protein
CTD PMID:16949557 PMID:18343235 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405
JBrowse link
G Gramd1b GRAM domain containing 1B increases expression ISO Nicotine results in increased expression of GRAMD1B mRNA CTD PMID:23825647 NCBI chr 8:49,551,642...49,790,965
Ensembl chr 8:49,556,332...49,791,052
JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 decreases methylation EXP Nicotine results in decreased methylation of GRID1 gene CTD PMID:32994467 NCBI chr16:10,145,018...10,894,184
Ensembl chr16:10,144,964...10,891,946
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GRID2 mRNA; [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:93,745,277...95,219,868
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression ISO Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Nicotine results in decreased expression of GRM1 mRNA CTD PMID:28339662 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443
JBrowse link
G Grm2 glutamate metabotropic receptor 2 affects expression EXP Nicotine affects the expression of GRM2 mRNA CTD PMID:28339662 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:116,158,810...116,171,857
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression ISO Nicotine results in increased expression of GRM5 mRNA CTD PMID:21955143 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649
JBrowse link
G Gsdma gasdermin A increases expression ISO Nicotine results in increased expression of GSDMA mRNA CTD PMID:23825647 NCBI chr10:84,110,590...84,135,804
Ensembl chr10:84,123,314...84,135,804
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein
Nicotine results in increased expression of GSK3A mRNA
Nicotine results in increased expression of and results in decreased phosphorylation of GSK3A protein
CTD PMID:12511591 PMID:31945395 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein
Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B protein
Nicotine results in increased expression of GSK3B mRNA
Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:12511591 PMID:31945395 PMID:33640489 PMID:35411647 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP
ISO
Nicotine results in decreased activity of GSR protein CTD PMID:19778253 PMID:20498001 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression
multiple interactions
increases expression
increases activity
EXP
ISO
Nicotine results in decreased expression of GSTA4 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTA4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 protein]
Nicotine results in increased expression of GSTA4 mRNA
Nicotine results in increased activity of GSTA4 protein
CTD PMID:9774145 PMID:20230807 PMID:23933227 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Nicotine results in decreased expression of GSTK1 mRNA CTD PMID:17997037 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO Nicotine results in decreased expression of GSTM2 mRNA CTD PMID:33640489 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Guca1a guanylate cyclase activator 1A decreases expression ISO Nicotine results in decreased expression of GUCA1A mRNA CTD PMID:16949557 NCBI chr 9:21,080,782...21,096,221
Ensembl chr 9:21,086,642...21,096,221
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079
JBrowse link
G H2az2 H2A.Z variant histone 2 decreases expression ISO Nicotine results in decreased expression of H2AZ2 mRNA CTD PMID:17456735 NCBI chr14:85,507,228...85,526,166
Ensembl chr14:85,507,228...85,526,207
Ensembl chr16:85,507,228...85,526,207
JBrowse link
G H2bc14 H2B clustered histone 14 increases expression ISO Nicotine results in increased expression of H2BC5 protein CTD PMID:35929799 NCBI chr17:47,488,627...47,489,008 JBrowse link
G H2bc4 H2B clustered histone 4 decreases expression ISO Nicotine results in decreased expression of H2BC4 mRNA CTD PMID:17456735 NCBI chr17:47,388,085...47,392,349
Ensembl chr17:47,404,375...47,419,020
JBrowse link
G H3c1 H3 clustered histone 1 increases expression ISO Nicotine results in increased expression of H3C1 protein CTD PMID:35929799 NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,795,396...41,797,281
Ensembl chr17:41,795,396...41,797,281
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 decreases expression EXP
ISO
Nicotine results in decreased expression of HAND1 mRNA; Nicotine results in decreased expression of HAND1 protein CTD PMID:24368670 PMID:31507073 NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nicotine results in increased expression of HAVCR1 protein CTD PMID:21511693 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,841,763...15,842,603
JBrowse link
G Hdac1 histone deacetylase 1 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HDAC1 mRNA
Nicotine results in increased expression of HDAC1 mRNA; Nicotine results in increased expression of HDAC1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]
CTD PMID:24709674 PMID:34245815 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
decreases expression
EXP
ISO
Nicotine results in increased expression of HDAC2 mRNA; Nicotine results in increased expression of HDAC2 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
Nicotine results in decreased expression of HDAC2 protein
CTD PMID:24709674 PMID:31507073 PMID:31846720 PMID:34245815 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311
JBrowse link
G Hdac4 histone deacetylase 4 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
CTD PMID:31846720 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Nicotine results in increased expression of HDAC7 mRNA CTD PMID:24709674 NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:130,803,013...130,841,017
JBrowse link
G Hddc2 HD domain containing 2 increases expression ISO Nicotine results in increased expression of HDDC2 mRNA CTD PMID:23825647 NCBI chr 1:28,100,669...28,133,008
Ensembl chr 1:28,083,521...28,132,977
JBrowse link
G Hells helicase, lymphoid specific multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] CTD PMID:20230807 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624
JBrowse link
G Hgf hepatocyte growth factor affects expression
decreases expression
multiple interactions
EXP
ISO
Nicotine affects the expression of HGF mRNA
Nicotine results in decreased expression of HGF protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA
CTD PMID:32512034 PMID:33091441 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of HIF1A protein
Nicotine results in decreased expression of HIF1A mRNA
resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]
CTD PMID:22687363 PMID:24793809 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]
Nicotine results in increased expression of HINT1 mRNA
CTD PMID:20230807 PMID:20514075 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HIPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HIPK1 mRNA] CTD PMID:20230807 NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:193,937,261...193,975,164
JBrowse link
G Hltf helicase-like transcription factor decreases expression ISO Nicotine results in decreased expression of HLTF mRNA CTD PMID:18247414 NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:104,478,772...104,538,818
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Nicotine results in decreased expression of HMGA1 mRNA CTD PMID:16949557 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
affects expression
ISO
EXP
Nicotine results in increased expression of HMGCR mRNA
Nicotine affects the expression of HMGCR mRNA
CTD PMID:23416264 PMID:31972234 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Nicotine results in increased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
affects expression
increases expression
multiple interactions
ISO
EXP
HMOX1 protein results in increased susceptibility to Nicotine
Nicotine affects the expression of HMOX1 mRNA
Nicotine results in increased expression of HMOX1 mRNA; Nicotine results in increased expression of HMOX1 protein
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]
CTD PMID:22954530 PMID:23933227 PMID:23942037 PMID:24095726 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 increases expression ISO Nicotine results in increased expression of HNRNPA3 mRNA CTD PMID:17456735 NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:80,985,969...80,996,043
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HNRNPC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:27,253,098...27,282,715
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 increases expression ISO Nicotine results in increased expression of HNRNPH2 mRNA CTD PMID:17456735 NCBI chr  X:102,074,175...102,080,115
Ensembl chr  X:102,074,179...102,081,025
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Nicotine results in decreased expression of HNRNPL mRNA CTD PMID:21955143 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Nicotine results in increased expression of HNRNPLL mRNA CTD PMID:17997037 NCBI chr 6:20,720,013...20,752,803
Ensembl chr 6:20,722,184...20,752,802
JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R increases expression ISO Nicotine results in increased expression of HNRNPR mRNA CTD PMID:17997037 NCBI chr 5:153,826,482...153,872,272
Ensembl chr 5:153,826,692...153,858,344
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Nicotine results in decreased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Nicotine results in increased expression of HOXB9 mRNA CTD PMID:23825647 NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,733,658...81,738,872
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 increases expression ISO Nicotine results in increased expression of HP1BP3 mRNA CTD PMID:16949557 NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:155,719,115...155,746,325
JBrowse link
G Hpca hippocalcin increases expression ISO Nicotine results in increased expression of HPCA mRNA CTD PMID:21955143 NCBI chr 5:146,739,978...146,750,961
Ensembl chr 5:146,739,978...146,749,983
JBrowse link
G Hpcal4 hippocalcin-like 4 increases expression ISO Nicotine results in increased expression of HPCAL4 mRNA CTD PMID:23825647 NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:140,739,635...140,751,530
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases activity
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]
Nicotine results in increased activity of HRAS protein
CTD PMID:15983034 PMID:20230807 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HSD11B1 mRNA
Nicotine affects the expression of HSD11B1 mRNA
ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
CTD PMID:21955143 PMID:22265867 PMID:26803847 PMID:31972234 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
affects expression
increases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of HSD11B2 mRNA; Nicotine results in decreased expression of HSD11B2 protein
Nicotine affects the expression of HSD11B2 mRNA
Nicotine results in increased expression of HSD11B2 mRNA; Nicotine results in increased expression of HSD11B2 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions
decreases expression
EXP
ISO
Taurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]
Nicotine results in decreased expression of HSD17B1 mRNA
Nicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 protein
CTD PMID:20498001 PMID:30959089 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression
EXP Nicotine results in decreased activity of HSD17B3 protein
Nicotine results in decreased expression of HSD17B3 mRNA; Nicotine results in decreased expression of HSD17B3 protein
CTD PMID:28986172 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases splicing ISO Nicotine results in increased splicing of HSD17B7 mRNA alternative form CTD PMID:23825647 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
decreases activity
EXP
ISO
Nicotine results in decreased expression of HSD3B1 mRNA; Nicotine results in decreased expression of HSD3B1 protein
Nicotine results in decreased activity of HSD3B1 protein
CTD PMID:28986172 PMID:30959089 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]
Nicotine results in increased expression of HSP90AA1 mRNA; Nicotine results in increased expression of HSP90AA1 protein
CTD PMID:12115584 PMID:20230807 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HSPA5
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:18477628 PMID:24201001 PMID:28082123 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of HTR1A protein
Nicotine results in increased expression of HTR1A protein
CTD PMID:21324836 PMID:30247698 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] CTD PMID:21316381 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein; Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]
Nicotine results in increased expression of HTR2A protein
CTD PMID:21316381 PMID:30247698 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Nicotine results in decreased expression of IBSP mRNA CTD PMID:29981921 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Nicotine results in increased expression of ICAM1 protein CTD PMID:12575837 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Nicotine results in decreased expression of ID1 mRNA CTD PMID:17997037 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685
JBrowse link
G Id2 inhibitor of DNA binding 2 increases splicing ISO Nicotine results in increased splicing of ID2 mRNA alternative form CTD PMID:23825647 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Nicotine results in decreased expression of ID3 mRNA CTD PMID:17456735 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression
increases expression
ISO Nicotine results in decreased expression of IDI1 mRNA
Nicotine results in increased expression of IDI1 mRNA
CTD PMID:16949557 PMID:17997037 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression
multiple interactions
ISO Nicotine results in increased expression of IFI27 mRNA
Nicotine inhibits the reaction [nickel chloride results in increased expression of IFI27 mRNA]
CTD PMID:23825647 PMID:37951547 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781
JBrowse link
G Ifi44 interferon-induced protein 44 increases expression ISO Nicotine results in increased expression of IFI44 mRNA CTD PMID:23825647 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Nicotine results in increased expression of IFI44L mRNA CTD PMID:23825647 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] CTD PMID:31154625 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IFITM1 mRNA CTD PMID:37951547 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression ISO Nicotine results in decreased expression of IFNAR1 mRNA CTD PMID:18247414 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein] CTD PMID:31154625 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487
JBrowse link
G Ifng interferon gamma multiple interactions ISO Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA] CTD PMID:24095726 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of IGF1 mRNA; Nicotine results in decreased expression of IGF1 protein
Nicotine affects the expression of IGF1 mRNA; Nicotine affects the expression of IGF1 protein
Nicotine results in increased expression of IGF1 mRNA
IGF1 protein inhibits the reaction [Nicotine results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Nicotine results in increased expression of BAX protein]; Nicotine results in decreased expression of and results in decreased secretion of IGF1 protein; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]
CTD PMID:20960268 PMID:22265867 PMID:29486207 PMID:31972234 PMID:39207236 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
increases expression
EXP Nicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R protein
Nicotine affects the expression of IGF1R mRNA
Nicotine results in increased expression of IGF1R mRNA
CTD PMID:20426880 PMID:20960268 PMID:22265867 PMID:31972234 PMID:39207236 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP Nicotine results in increased expression of IGF2 mRNA CTD PMID:29486207 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667
JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 increases expression ISO Nicotine results in increased expression of IGF2BP2 mRNA CTD PMID:17997037 NCBI chr11:92,378,908...92,478,893
Ensembl chr11:92,378,908...92,478,867
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Nicotine results in increased expression of IGFBP2 mRNA CTD PMID:23825647 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Nicotine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:133,947,717...133,963,154
Ensembl chr  X:133,947,429...133,962,962
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO Nicotine results in increased expression of IGSF3 mRNA CTD PMID:23825647 NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:191,500,045...191,588,249
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression EXP Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
decreases secretion
ISO Nicotine results in decreased expression of IL10 mRNA
Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Nicotine results in decreased secretion of IL10 protein
[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:18247414 PMID:21237301 PMID:29673796 PMID:31926917 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] CTD PMID:23199342 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
JBrowse link
G Il18 interleukin 18 increases secretion
increases expression
multiple interactions
ISO
EXP
Nicotine results in increased secretion of IL18 protein
Nicotine results in increased expression of IL18 protein
Nicotine results in increased expression of IL18 mRNA
CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]
CTD PMID:35131329 PMID:39098741 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Nicotine results in increased expression of and results in increased secretion of IL1B protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]
Nicotine results in increased expression of IL1B mRNA
Nicotine results in decreased expression of IL1B protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Nicotine results in increased expression of IL1B mRNA; Nicotine results in increased expression of IL1B protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:15976189 PMID:16254210 PMID:18082304 PMID:19673871 PMID:20943775 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions
increases expression
EXP methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]
Nicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 protein
CTD PMID:27180639 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin] CTD PMID:27180639 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Nicotine results in decreased susceptibility to IL2 protein CTD PMID:15231866 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il33 interleukin 33 increases secretion
multiple interactions
ISO Nicotine results in increased secretion of IL33 protein
[Nicotine co-treated with Quartz] results in increased expression of IL33 protein
Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of IL33 protein]
CTD PMID:29673796 PMID:36868510 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha decreases expression ISO Nicotine results in decreased expression of IL3RA mRNA CTD PMID:18247414 NCBI chr12:21,431,848...21,437,336
Ensembl chr12:21,431,848...21,437,250
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of IL4RA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] CTD PMID:20230807 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
decreases secretion
decreases expression
increases expression
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Nicotine results in increased expression of and results in increased secretion of IL6 protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]
Nicotine results in increased secretion of IL6 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA
Nicotine results in decreased secretion of IL6 protein
Nicotine results in decreased expression of IL6 mRNA; Nicotine results in decreased expression of IL6 protein
Nicotine results in increased expression of IL6 mRNA; Nicotine results in increased expression of IL6 protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]
CTD PMID:18082304 PMID:19673871 PMID:20943775 PMID:22093924 PMID:23199342 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Il7 interleukin 7 multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL7 protein CTD PMID:18082304 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389
JBrowse link
G Il9 interleukin 9 decreases expression ISO Nicotine results in decreased expression of IL9 mRNA CTD PMID:18247414 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,117,028...8,120,151
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 decreases expression ISO Nicotine results in decreased expression of INPPL1 mRNA CTD PMID:17456735 NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:165,595,063...165,609,503
JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression
ISO
EXP
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein]
CTD PMID:29155039 PMID:31857090 PMID:33091441 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Ins2 insulin 2 increases expression EXP Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Insig1 insulin induced gene 1 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of INSIG1 mRNA
Nicotine results in decreased expression of INSIG1 mRNA
CTD PMID:23416264 PMID:26776438 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778
JBrowse link
G Insr insulin receptor decreases expression EXP Nicotine results in decreased expression of INSR mRNA; Nicotine results in decreased expression of INSR protein CTD PMID:20960268 PMID:22265867 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825
JBrowse link
G Irf6 interferon regulatory factor 6 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IRF6 mRNA CTD PMID:37951547 NCBI chr13:107,200,876...107,220,083
Ensembl chr13:107,200,731...107,220,049
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA] CTD PMID:31154625 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023
JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of IRF8 mRNA
[nickel chloride co-treated with Nicotine] results in increased expression of IRF8 mRNA
CTD PMID:17456735 PMID:37951547 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Nicotine results in increased expression of IRF9 mRNA CTD PMID:33640489 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538
JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:31,384,803...31,388,241
Ensembl chr19:31,384,833...31,388,238
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA] CTD PMID:31154625 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of ISG20 mRNA CTD PMID:37951547 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401
JBrowse link
G Itga2b integrin subunit alpha 2b decreases expression ISO Nicotine results in decreased expression of ITGA2B mRNA; Nicotine results in decreased expression of ITGA2B protein CTD PMID:21385097 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Nicotine results in decreased expression of ITGAL mRNA CTD PMID:18247414 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Nicotine results in increased expression of ITGAV mRNA CTD PMID:17997037 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Nicotine results in decreased expression of ITGB1 protein CTD PMID:11338295 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269
JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Nicotine results in decreased expression of ITGB3 mRNA; Nicotine results in decreased expression of ITGB3 protein CTD PMID:21385097 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression EXP Nicotine results in increased expression of ITGB5 mRNA CTD PMID:20426880 NCBI chr11:80,333,588...80,449,373
Ensembl chr11:80,333,590...80,449,373
JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:54,955,549...54,978,455
Ensembl chr15:54,955,552...54,978,455
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B increases expression EXP Nicotine results in increased expression of ITPKB mRNA CTD PMID:11478936 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:94,601,167...94,696,179
JBrowse link
G Ivl involucrin decreases expression ISO Nicotine results in decreased expression of IVL protein CTD PMID:16011614 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578
JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Nicotine results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:148,147,229...148,151,915
JBrowse link
G Jak2 Janus kinase 2 increases response to substance
increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
JAK2 results in increased susceptibility to Nicotine
Nicotine results in increased phosphorylation of JAK2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of JAK2 protein]
Nicotine results in decreased expression of JAK2 mRNA
CTD PMID:20943775 PMID:29155039 PMID:34153408 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of JMJD6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of JMJD6 mRNA] CTD PMID:20230807 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Nicotine results in increased expression of JUN protein
Nicotine results in increased phosphorylation of JUN protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA]
CTD PMID:11592233 PMID:17003101 PMID:17021677 PMID:21511693 PMID:34890707 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Nicotine results in increased expression of JUNB mRNA
Nicotine results in decreased expression of JUNB mRNA
CTD PMID:17456735 PMID:17997037 PMID:18805435 PMID:21955143 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218
JBrowse link
G Kat6b lysine acetyltransferase 6B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KAT6B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KAT6B mRNA] CTD PMID:20230807 NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases expression ISO Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP Nicotine results in decreased expression of KCNK1 mRNA CTD PMID:11478936 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051
JBrowse link
G Kdm7a lysine demethylase 7A increases expression ISO Nicotine results in increased expression of KDM7A mRNA CTD PMID:16949557 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:68,871,677...68,931,506
JBrowse link
G Kdr kinase insert domain receptor increases expression
decreases expression
EXP Nicotine results in increased expression of KDR mRNA
Nicotine results in decreased expression of KDR protein
CTD PMID:32512034 PMID:33091441 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Kif21b kinesin family member 21B increases expression ISO Nicotine results in increased expression of KIF21B mRNA CTD PMID:23825647 NCBI chr13:50,127,842...50,177,822
Ensembl chr13:50,127,842...50,177,822
JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KIF3B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:162,218,621...162,258,191
Ensembl chr 3:162,218,682...162,258,581
JBrowse link
G Klf10 KLF transcription factor 10 decreases expression
increases expression
ISO Nicotine results in decreased expression of KLF10 mRNA
Nicotine results in increased expression of KLF10 mRNA
CTD PMID:17456735 PMID:17997037 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948
JBrowse link
G Klf11 KLF transcription factor 11 decreases expression ISO Nicotine results in decreased expression of KLF11 mRNA CTD PMID:18247414 NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:47,014,326...47,037,044
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Nicotine results in increased expression of KLF4 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592
JBrowse link
G Klk5 kallikrein related-peptidase 5 increases expression ISO Nicotine results in increased expression of KLK5 mRNA CTD PMID:23825647 NCBI chr 1:103,432,743...103,442,011
Ensembl chr 1:103,433,065...103,441,305
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] CTD PMID:12588870 NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:10,353,735...10,568,620
JBrowse link
G Kng1 kininogen 1 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of KNG1 protein alternative form
Capsaicin promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]; Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]
CTD PMID:7807204 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148
JBrowse link
G Krt15 keratin 15 increases expression ISO Nicotine results in increased expression of KRT15 mRNA CTD PMID:23825647 NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142
JBrowse link
G Krt80 keratin 80 increases expression ISO Nicotine results in increased expression of KRT80 mRNA CTD PMID:23825647 NCBI chr 7:134,341,951...134,363,872
Ensembl chr 7:134,341,956...134,364,211
JBrowse link
G Krt85 keratin 85 increases expression ISO Nicotine results in increased expression of KRT85 mRNA CTD PMID:23825647 NCBI chr 7:134,508,913...134,515,786
Ensembl chr 7:134,508,913...134,515,786
JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Nicotine results in increased expression of LAMB1 mRNA CTD PMID:16949557 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Nicotine results in decreased expression of LAMP2 protein CTD PMID:33010382 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675
JBrowse link
G Lce1b late cornified envelope 1B increases expression ISO Nicotine results in increased expression of LCE1B mRNA CTD PMID:23825647 NCBI chr 2:180,951,824...180,953,140 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of LCK protein CTD PMID:17709503 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 affects response to substance ISO LCP1 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr15:56,846,375...56,954,090
Ensembl chr15:56,847,433...56,954,092
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Nicotine results in increased expression of LDLR mRNA CTD PMID:23416264 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Ldlrad3 low density lipoprotein receptor class A domain containing 3 increases splicing ISO Nicotine results in increased splicing of LDLRAD3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:108,694,528...108,936,330
Ensembl chr 3:108,694,528...108,936,368
JBrowse link
G Lep leptin increases expression
decreases response to substance
EXP Nicotine results in increased expression of LEP protein
Nicotine results in decreased susceptibility to LEP protein
CTD PMID:23623838 PMID:29155039 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Nicotine results in increased expression of LEPR mRNA
Nicotine results in decreased expression of LEPR mRNA
CTD PMID:22265867 PMID:29155039 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
JBrowse link
G Lgals1 galectin 1 increases expression ISO Nicotine results in increased expression of LGALS1 mRNA CTD PMID:23825647 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases secretion
EXP
ISO
Nicotine results in decreased expression of LHB mRNA; Nicotine results in decreased expression of LHB protein
Nicotine results in increased secretion of LHB protein
CTD PMID:12893845 PMID:20498001 PMID:28986172 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO Nicotine results in increased expression of LIG4 mRNA CTD PMID:16949557 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:116,859,425...116,872,363
Ensembl chr 3:116,860,282...116,872,363
JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Nicotine results in decreased expression of LIPE mRNA CTD PMID:29155039 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
Nicotine results in increased expression of LITAF mRNA
CTD PMID:12588870 PMID:21955143 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930
JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO Nicotine results in decreased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:76,106,319...76,119,807
Ensembl chr  X:76,106,071...76,119,808
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Nicotine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 increases expression ISO Nicotine results in increased expression of LRRFIP1 mRNA CTD PMID:16949557 NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:99,039,614...99,167,779
JBrowse link
G Lrrtm4 leucine rich repeat transmembrane neuronal 4 increases methylation EXP Nicotine results in increased methylation of LRRTM4 gene CTD PMID:32994467 NCBI chr 4:114,103,783...114,894,696
Ensembl chr 4:114,103,870...114,109,726
JBrowse link
G Ltb lymphotoxin beta decreases expression ISO Nicotine results in decreased expression of LTB mRNA CTD PMID:18247414 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054
JBrowse link
G Ltf lactotransferrin decreases expression ISO Nicotine results in decreased expression of LTF mRNA CTD PMID:23825647 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA CTD PMID:28065790 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303
JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member decreases expression ISO Nicotine results in decreased expression of LYL1 mRNA CTD PMID:17456735 NCBI chr19:40,356,967...40,359,834
Ensembl chr19:40,354,819...40,359,834
JBrowse link
G Lysmd3 LysM domain containing 3 affects response to substance ISO LYSMD3 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr 2:13,669,465...13,675,622
Ensembl chr 2:13,669,429...13,678,643
JBrowse link
G Madd MAP-kinase activating death domain decreases expression ISO Nicotine results in decreased expression of MADD mRNA CTD PMID:18247414 NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:97,570,787...97,613,509
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression EXP Nicotine results in increased expression of MAP2K6 mRNA CTD PMID:20426880 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP2K7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in increased activity of MAPK1 protein
Nicotine results in increased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPK1 mRNA]
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Nicotine results in increased expression of MAPK1 protein modified form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with Ethanol] results in increased phosphorylation of MAPK1 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17459420 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression ISO Nicotine results in decreased expression of MAPK11 mRNA CTD PMID:17135361 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases expression ISO Nicotine results in decreased expression of MAPK13 mRNA CTD PMID:17135361 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK3 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
Nicotine results in decreased expression of MAPK3 protein
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA; Nicotine results in decreased expression of MAPK3 protein
Nicotine results in increased expression of MAPK3 protein modified form
Nicotine results in increased activity of MAPK3 protein
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17135361 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
increases expression
increases activity
ISO
EXP
Nicotine results in increased phosphorylation of MAPK8 protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
Nicotine results in increased expression of MAPK8 mRNA
Nicotine results in increased activity of MAPK8 protein
Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
CTD PMID:11592233 PMID:17021677 PMID:20426880 PMID:20727180 PMID:21511693 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Nicotine results in decreased expression of MAPK9 mRNA CTD PMID:26776438 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 increases expression ISO Nicotine results in increased expression of MAST2 mRNA CTD PMID:33640489 NCBI chr 5:135,013,006...135,152,195
Ensembl chr 5:135,012,058...135,152,161
JBrowse link
G Mbp myelin basic protein increases phosphorylation EXP Nicotine results in increased phosphorylation of MBP protein CTD PMID:15983034 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein]; [Nicotine results in increased phosphorylation of MCL1 protein] which results in increased expression of and results in increased stability of MCL1 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] CTD PMID:19903766 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 increases expression EXP Nicotine results in increased expression of MCMDC2 mRNA CTD PMID:27782041 NCBI chr 5:14,071,609...14,120,435
Ensembl chr 5:14,080,968...14,120,351
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 decreases expression ISO Nicotine results in decreased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:7,803,382...8,493,596
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of MDH2 protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of MDH2 protein]
CTD PMID:29972271 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791
JBrowse link
G Me1 malic enzyme 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA] CTD PMID:20230807 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275
JBrowse link
G Med24 mediator complex subunit 24 increases expression ISO Nicotine results in increased expression of MED24 mRNA CTD PMID:23825647 NCBI chr10:84,160,866...84,198,607
Ensembl chr10:84,160,866...84,186,379
JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Nicotine results in increased expression of MED28 mRNA CTD PMID:16949557 NCBI chr14:69,807,319...69,816,115
Ensembl chr14:69,807,319...69,816,115
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression EXP Nicotine affects the expression of MEF2C mRNA CTD PMID:20426880 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit increases expression ISO Nicotine results in increased expression of METTL3 mRNA CTD PMID:17456735 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487
JBrowse link
G Mgp matrix Gla protein multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein CTD PMID:19910445 NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859
JBrowse link
G Mir15b microRNA 15b increases methylation
decreases expression
ISO Nicotine results in increased methylation of MIR15B gene
Nicotine results in decreased expression of MIR15B mRNA
CTD PMID:33640489 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275
JBrowse link
G Mir98 microRNA 98 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of MIR98 mRNA
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of MIR98 mRNA]
CTD PMID:33082140 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:24,460,648...24,460,755
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO Nicotine results in decreased expression of MIRLET7B mRNA CTD PMID:33082140 NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:118,684,038...118,684,122
JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO Nicotine results in decreased expression of MIRLET7D mRNA CTD PMID:33082140 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,322,260...16,322,357
JBrowse link
G Mirlet7g microRNA let-7g decreases expression ISO Nicotine results in decreased expression of MIRLET7G mRNA CTD PMID:33082140 NCBI chr 8:115,701,020...115,701,107
Ensembl chr 8:115,701,007...115,701,115
JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO Nicotine results in decreased expression of MIRLET7I mRNA CTD PMID:33082140 NCBI chr 7:60,527,877...60,527,961 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
decreases expression
EXP
ISO
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]
[Nicotine co-treated with Quartz] results in increased expression of MKI67 protein
Nicotine results in increased expression of MKI67 protein
Nicotine results in decreased expression of MKI67 protein
CTD PMID:29501575 PMID:30959089 PMID:31678612 PMID:36868510 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
JBrowse link
G Mlph melanophilin increases expression ISO Nicotine results in increased expression of MLPH mRNA CTD PMID:23825647 NCBI chr 9:98,955,036...98,990,566
Ensembl chr 9:98,955,141...98,990,556
JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO Nicotine results in increased expression of MME mRNA CTD PMID:23825647 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
Nicotine results in increased expression of MMP1 mRNA; Nicotine results in increased expression of MMP1 protein
CTD PMID:17151781 PMID:18986645 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of MMP13 mRNA; Nicotine results in increased expression of MMP13 protein
NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]
Nicotine results in decreased expression of MMP13 mRNA
CTD PMID:17151781 PMID:34153408 PMID:39098741 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]
Nicotine results in decreased expression of MMP2 mRNA
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA
Nicotine results in decreased expression of MMP2 protein
Nicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 protein
CTD PMID:14569062 PMID:17151781 PMID:18986645 PMID:20448088 PMID:23825647 More... NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of MMP3 mRNA; Nicotine results in increased expression of MMP3 protein
CTD PMID:17151781 PMID:18986645 PMID:39098741 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression
affects response to substance
ISO CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 protein
MMP7 promoter SNP affects the susceptibility to Nicotine
CTD PMID:20061081 PMID:20230807 PMID:25847246 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of MMP9 mRNA; Nicotine results in increased expression of MMP9 protein
MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
Nicotine results in decreased expression of MMP9 protein
CTD PMID:14569062 PMID:20061081 PMID:20448088 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of MPO protein
Nicotine results in increased activity of MPO protein
Acetylcysteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; erdosteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; Nicotine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Vitamin E inhibits the reaction [Nicotine results in increased activity of MPO protein]
CTD PMID:15976189 PMID:17216608 PMID:23810507 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Nicotine results in decreased expression of MRM3 mRNA CTD PMID:17997037 NCBI chr10:61,594,155...61,623,659
Ensembl chr10:61,593,999...61,600,865
JBrowse link
G Mrpl10 mitochondrial ribosomal protein L10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MRPL10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL10 mRNA] CTD PMID:20230807 NCBI chr10:82,522,470...82,530,886
Ensembl chr10:82,522,297...82,530,873
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728
JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 decreases expression ISO Nicotine results in decreased expression of MRPL41 mRNA CTD PMID:17997037 NCBI chr 3:28,178,837...28,179,755
Ensembl chr 3:28,162,197...28,181,250
JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression ISO Nicotine results in increased expression of MRPL54 mRNA CTD PMID:17456735 NCBI chr 7:9,103,525...9,106,045
Ensembl chr 7:9,103,525...9,106,045
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:184,763,529...184,775,777
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Nicotine results in increased expression of MSMO1 mRNA CTD PMID:23416264 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445
JBrowse link
G Mst1 macrophage stimulating 1 decreases expression ISO Nicotine results in decreased expression of MST1 mRNA CTD PMID:18247414 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015
JBrowse link
G Msx1 msh homeobox 1 increases expression EXP Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 NCBI chr14:77,185,802...77,189,735
Ensembl chr14:77,185,802...77,189,735
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP Nicotine results in decreased expression of COX1 protein CTD PMID:28681937 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853
JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Nicotine results in increased expression of MT1E mRNA CTD PMID:23825647 NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein] CTD PMID:23933227 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080
JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MTCH1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:7,391,558...7,415,291
Ensembl chr20:7,391,565...7,415,042
JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:1,784,218...1,828,463
Ensembl chr14:1,783,627...1,828,414
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 increases expression ISO Nicotine results in increased expression of MTIF2 mRNA CTD PMID:16949557 NCBI chr14:107,465,719...107,486,663
Ensembl chr14:107,466,861...107,487,003
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
multiple interactions
increases phosphorylation
EXP
ISO
Nicotine results in decreased expression of MTOR mRNA
Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
Nicotine results in increased phosphorylation of MTOR protein
CTD PMID:26776438 PMID:30836163 PMID:31926917 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of MX1 mRNA CTD PMID:37951547 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO Nicotine results in decreased expression of MYBL2 mRNA CTD PMID:16949557 NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:172,116,550...172,153,221
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases activity
multiple interactions
increases expression
decreases expression
ISO Nicotine results in increased activity of MYC protein
EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]
Nicotine results in decreased expression of MYC mRNA
Nicotine results in decreased activity of and results in decreased expression of MYC protein
CTD PMID:17135361 PMID:17459420 PMID:30836163 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Nicotine results in increased expression of MYH7 protein CTD PMID:25280790 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194
JBrowse link
G Myl6 myosin light chain 6 decreases expression ISO Nicotine results in decreased expression of MYL6 mRNA CTD PMID:16949557 NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:1,495,747...1,498,344
JBrowse link
G Myo5b myosin Vb decreases expression ISO Nicotine results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:70,313,717...70,613,918
Ensembl chr18:70,311,990...70,613,918
JBrowse link
G Myo9a myosin IXA increases expression ISO Nicotine results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:69,044,885...69,245,231
JBrowse link
G Myof myoferlin increases splicing ISO Nicotine results in increased splicing of MYOF mRNA alternative form CTD PMID:23825647 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768
JBrowse link
G Mypn myopalladin decreases expression EXP Nicotine results in decreased expression of MYPN mRNA CTD PMID:27782041 NCBI chr20:25,435,554...25,521,149
Ensembl chr20:25,435,554...25,521,149
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions EXP Nicotine inhibits the reaction [Acetic Acid results in decreased expression of NAMPT protein] CTD PMID:23810507 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544
JBrowse link
G Nanog Nanog homeobox increases expression
multiple interactions
ISO Nicotine results in increased expression of NANOG mRNA; Nicotine results in increased expression of NANOG protein
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of NANOG protein; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]
CTD PMID:23219715 PMID:30259641 PMID:31507073 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061
JBrowse link
G Ncam1 neural cell adhesion molecule 1 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]
[nickel chloride co-treated with Nicotine] results in increased expression of NCAM1 mRNA
CTD PMID:23933227 PMID:37951547 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of NCF1 protein] CTD PMID:34171359 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Nicotine results in increased expression of NDUFA5 mRNA CTD PMID:16949557 NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 decreases expression EXP Nicotine results in decreased expression of NDUFAF2 mRNA CTD PMID:27782041 NCBI chr 2:41,269,141...41,380,895
Ensembl chr 2:41,269,141...41,380,763
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFB5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:117,447,035...117,461,590
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression EXP Nicotine results in decreased expression of NDUFB8 protein CTD PMID:28681937 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Nicotine results in increased expression of NEDD9 mRNA CTD PMID:17456735 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668
JBrowse link
G Nefm neurofilament medium chain increases expression ISO Nicotine results in increased expression of NEFM protein CTD PMID:20457658 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:46,535,517...46,541,163
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:177,618,314...177,747,380
JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases splicing ISO Nicotine results in increased splicing of NFE2L1 mRNA alternative form CTD PMID:23825647 NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
decreases expression
increases expression
ISO
EXP
Nicotine results in increased activity of NFKB1 protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of NFKB1 mRNA; Nicotine results in decreased expression of NFKB1 protein
Nicotine results in increased expression of NFKB1 mRNA
Vitamin K 3 inhibits the reaction [Nicotine results in increased activity of NFKB1 protein]
CTD PMID:16598845 PMID:17135361 PMID:27984197 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Aerosols co-treated with Nicotine] results in increased expression of NFKB2 mRNA CTD PMID:33469865 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
increases degradation
increases expression
ISO
EXP
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; NSC 74859 inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Nicotine results in increased phosphorylation of NFKBIA protein
Nicotine results in increased degradation of NFKBIA protein
Nicotine results in increased expression of NFKBIA mRNA
CTD PMID:17021677 PMID:17456735 PMID:20943775 PMID:34171359 PMID:34890707 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO Nicotine results in decreased expression of NFKBIE mRNA CTD PMID:18247414 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta decreases expression ISO Nicotine results in decreased expression of NFYB mRNA CTD PMID:18247414 NCBI chr 7:22,852,543...22,868,116
Ensembl chr 7:22,852,546...22,882,294
JBrowse link
G Ngb neuroglobin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NGB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA] CTD PMID:20230807 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786
JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of NGF mRNA
Nicotine promotes the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of NGF mRNA]
Nicotine results in increased expression of NGF mRNA; Nicotine results in increased expression of NGF protein
Nicotine results in increased expression of and results in increased secretion of NGF protein
CTD PMID:30076938 PMID:33082140 PMID:39505136 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Nicotine results in increased expression of NGFR mRNA CTD PMID:30076938 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305
JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO Nicotine results in decreased expression of NHERF2 mRNA CTD PMID:18247414 NCBI chr10:14,167,005...14,177,519
Ensembl chr10:14,167,005...14,177,593
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO Nicotine results in increased expression of NIBAN1 mRNA CTD PMID:23825647 NCBI chr13:66,224,219...66,377,728
Ensembl chr13:66,224,021...66,377,724
JBrowse link
G Nin ninein increases expression
multiple interactions
ISO Nicotine results in increased expression of NIN mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
CTD PMID:16949557 NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:94,263,206...94,363,610
JBrowse link
G Nkain3 Sodium/potassium transporting ATPase interacting 3 decreases methylation EXP Nicotine results in decreased methylation of NKAIN3 gene CTD PMID:35026373 NCBI chr 5:38,410,576...39,106,910
Ensembl chr 5:38,386,841...39,106,385
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO
EXP
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of NLRP3 mRNA]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of NLRP3 mRNA; Nicotine results in increased expression of NLRP3 protein
CTD PMID:35131329 PMID:39098741 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO Nicotine results in decreased expression of NME3 mRNA CTD PMID:18247414 NCBI chr10:14,421,922...14,422,878
Ensembl chr10:14,421,702...14,422,907
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 decreases expression ISO Nicotine results in decreased expression of NME6 mRNA CTD PMID:17997037 NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:118,711,036...118,718,288
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of NOS2 mRNA; Nicotine results in increased expression of NOS2 protein
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]
Nicotine results in decreased expression of NOS2 mRNA; Nicotine results in decreased expression of NOS2 protein
Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]
[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:16254210 PMID:16927020 PMID:17135361 PMID:18247414 PMID:19673871 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Nicotine results in increased expression of NOS3 mRNA CTD PMID:11166759 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Notch4 notch receptor 4 multiple interactions
decreases expression
EXP [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
Nicotine results in decreased expression of NOTCH4 protein
CTD PMID:20722969 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Nicotine results in increased expression of NOX4 protein CTD PMID:20685820 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
JBrowse link
G Npas3 neuronal PAS domain protein 3 decreases expression ISO Nicotine results in decreased expression of NPAS3 mRNA CTD PMID:23825647 NCBI chr 6:76,438,064...77,263,185
Ensembl chr 6:76,438,260...77,263,185
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:68,205,602...68,247,940
Ensembl chr13:68,205,603...68,247,999
JBrowse link
G Npy neuropeptide Y multiple interactions
decreases expression
increases expression
EXP Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA]
Nicotine results in decreased expression of NPY protein
Nicotine results in increased expression of NPY mRNA; Nicotine results in increased expression of NPY protein
CTD PMID:1907749 PMID:2233698 PMID:23623838 PMID:32512034 PMID:33091441 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
decreases expression
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]
Nicotine results in decreased expression of NR1H2 mRNA; Nicotine results in decreased expression of NR1H2 protein
CTD PMID:30036686 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
decreases expression
EXP
ISO
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]; Nicotine results in increased expression of and results in increased activity of NR1H3 protein
Nicotine results in decreased expression of NR1H3 mRNA; Nicotine results in decreased expression of NR1H3 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]
CTD PMID:24368177 PMID:30036686 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of NR3C1 mRNA
Nicotine results in decreased expression of NR3C1 protein
Nicotine results in increased expression of NR3C1 mRNA; Nicotine results in increased expression of NR3C1 protein
CTD PMID:22265867 PMID:22975262 PMID:31783125 PMID:31972234 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression EXP Nicotine results in decreased expression of NR3C2 mRNA CTD PMID:22975262 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
ISO Nicotine results in increased expression of NR4A1 mRNA
Nicotine results in decreased expression of NR4A1 mRNA
CTD PMID:17456735 PMID:21955143 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of NR5A1 mRNA; Nicotine results in decreased expression of NR5A1 protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]
CTD PMID:24709674 PMID:28986172 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Nicotine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,335,426...28,344,354
Ensembl chr17:28,334,616...28,344,354
JBrowse link
G Nrxn3 neurexin 3 increases expression
increases methylation
ISO
EXP
Nicotine results in increased expression of NRXN3 mRNA
Nicotine results in increased methylation of NRXN3 gene
CTD PMID:21955143 PMID:32994467 NCBI chr 6:113,372,667...115,004,073
Ensembl chr 6:113,443,524...115,002,540
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NSF mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621
JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression EXP Nicotine results in increased expression of NT5DC1 mRNA CTD PMID:27782041 NCBI chr20:39,660,707...39,763,647
Ensembl chr20:39,660,707...39,786,449
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Nicotine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:200,151,979...200,515,031
Ensembl chr 2:200,151,979...200,515,031
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of NTRK1 mRNA
Nicotine promotes the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]
CTD PMID:30076938 PMID:39505136 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of NTRK2 protein
[Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein]
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]
CTD PMID:16790237 PMID:36868510 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO Nicotine results in increased expression of NTSR1 mRNA CTD PMID:23825647 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:187,983,778...188,033,934
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Nicotine results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:32,075,002...32,091,491
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression
multiple interactions
ISO Nicotine results in increased expression of OAS1 mRNA
Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]
CTD PMID:23825647 PMID:31154625 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases activity
multiple interactions
EXP Nicotine results in decreased activity of OGDH protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of OGDH protein]
CTD PMID:29972271 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO OGG1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases expression ISO Nicotine results in increased expression of OGT mRNA CTD PMID:16949557 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:70,811,319...70,856,123
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO Nicotine results in decreased expression of OLFM4 mRNA CTD PMID:23825647 NCBI chr15:61,790,889...61,838,773
Ensembl chr15:61,671,271...61,838,764
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Nicotine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:249,840,539...249,858,423
Ensembl chr 1:249,840,539...249,858,190
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO [naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO Nicotine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 affects response to substance ISO OPRL1 protein affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of OR4D6 mRNA CTD PMID:28065790 NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:218,463,801...218,464,745
JBrowse link
G Orc2 origin recognition complex, subunit 2 increases expression ISO Nicotine results in increased expression of ORC2 mRNA CTD PMID:16949557 NCBI chr 9:67,496,097...67,532,548
Ensembl chr 9:67,496,825...67,526,649
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of P3H3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:159,332,514...159,348,428
Ensembl chr 4:159,332,434...159,348,004
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP Nicotine results in decreased expression of P4HB protein CTD PMID:28681937 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA] CTD PMID:20230807 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803
JBrowse link
G Pank3 pantothenate kinase 3 increases expression ISO Nicotine results in increased expression of PANK3 mRNA CTD PMID:16949557 NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,733,127...20,757,015
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA] CTD PMID:20230807 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
ISO
EXP
Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein]
CTD PMID:20457658 PMID:22743290 PMID:24095863 PMID:29972271 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases splicing ISO Nicotine results in increased splicing of PARP4 mRNA alternative form CTD PMID:23825647 NCBI chr15:34,806,203...34,908,492
Ensembl chr15:34,816,701...34,944,433
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:118,177,565...118,480,301
JBrowse link
G Pax3 paired box 3 decreases expression EXP Nicotine results in decreased expression of PAX3 mRNA CTD PMID:20339300 NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:87,016,999...87,124,141
JBrowse link
G Pax6 paired box 6 decreases expression EXP Nicotine results in decreased expression of PAX6 mRNA CTD PMID:28555334 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763
JBrowse link
G Pax8 paired box 8 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of PAX8 mRNA
Nicotine results in decreased expression of PAX8 mRNA
CTD PMID:23825647 PMID:26776438 NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:27,584,002...27,640,631
JBrowse link
G Pcf11 PCF11 cleavage and polyadenylation factor subunit increases expression ISO Nicotine results in increased expression of PCF11 mRNA CTD PMID:17456735 NCBI chr 1:156,109,724...156,136,950
Ensembl chr 1:156,109,724...156,136,435
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of PCNA protein
Nicotine results in decreased expression of PCNA protein
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein]
CTD PMID:18448488 PMID:20106947 PMID:30896085 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Nicotine results in decreased expression of PDE10A mRNA CTD PMID:21955143 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051
JBrowse link
G Pdgfa platelet derived growth factor subunit A affects expression EXP Nicotine affects the expression of PDGFA mRNA CTD PMID:20426880 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
increases expression
increases secretion
ISO
EXP
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA]; 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein] CTD PMID:16149045 PMID:16254210 PMID:32512034 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PDGFRB protein
Nicotine results in decreased phosphorylation of and results in decreased activity of PDGFRB protein
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein]
CTD PMID:16149045 PMID:20447445 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PDIA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO Nicotine results in increased expression of PDK1 mRNA CTD PMID:31945395 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 increases expression ISO Nicotine results in increased expression of PDK2 mRNA CTD PMID:31945395 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355
JBrowse link
G Pdlim2 PDZ and LIM domain 2 increases expression ISO Nicotine results in increased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958
JBrowse link
G Penk proenkephalin affects response to substance ISO PENK protein affects the susceptibility to Nicotine CTD PMID:15689546 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Nicotine results in increased expression of PER1 mRNA CTD PMID:17456735 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 decreases expression ISO Nicotine results in decreased expression of PES1 mRNA CTD PMID:17997037 NCBI chr14:83,074,346...83,090,726
Ensembl chr14:83,074,319...83,091,718
JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:28,288,210...28,341,198
Ensembl chr18:28,287,913...28,341,123
JBrowse link
G Pfn1 profilin 1 decreases expression EXP Nicotine results in decreased expression of PFN1 mRNA CTD PMID:11478936 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611
JBrowse link
G Pgf placental growth factor increases expression EXP Nicotine results in increased expression of PGF mRNA CTD PMID:32512034 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747
JBrowse link
G Pgr progesterone receptor decreases expression ISO Nicotine results in decreased expression of PGR mRNA CTD PMID:27552315 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
JBrowse link
G Phb1 prohibitin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB1 mRNA] CTD PMID:20230807 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233
JBrowse link
G Phf21a PHD finger protein 21A increases expression ISO Nicotine results in increased expression of PHF21A mRNA CTD PMID:16949557 NCBI chr 3:98,600,933...98,791,132
Ensembl chr 3:98,613,844...98,787,350
JBrowse link
G Phf3 PHD finger protein 3 increases expression ISO Nicotine results in increased expression of PHF3 mRNA CTD PMID:16949557 NCBI chr 9:40,559,929...40,632,096
Ensembl chr 9:40,559,929...40,632,056
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO Nicotine results in increased expression of PHGDH mRNA CTD PMID:23825647 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 increases expression ISO Nicotine results in increased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:53,900,338...53,949,518
JBrowse link
G Phldb3 pleckstrin homology-like domain, family B, member 3 decreases expression EXP Nicotine results in decreased expression of PHLDB3 mRNA CTD PMID:27782041 NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:89,328,819...89,347,436
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 affects response to substance ISO PHLPP gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr13:22,823,132...23,045,619
Ensembl chr13:22,823,132...23,045,619
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHTF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA]
Nicotine results in decreased expression of PHTF1 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 2:194,161,343...194,249,925
Ensembl chr 2:194,161,000...194,219,530
JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Nicotine results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:112,677,322...112,697,257
JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Nicotine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:33,672,832...33,687,747
Ensembl chr  X:33,674,923...33,687,636
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:76,876,894...76,879,420
Ensembl chr13:76,872,922...76,880,224
JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F increases expression ISO Nicotine results in increased expression of PIGF mRNA CTD PMID:16949557 NCBI chr 6:13,343,134...13,371,237
Ensembl chr 6:13,342,869...13,393,214
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO Nicotine results in increased expression of PIK3CA mRNA CTD PMID:16949557 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PIN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA] CTD PMID:20230807 NCBI chr 8:27,465,538...27,477,016 JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of PKLR mRNA CTD PMID:28065790 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
G Pkn2 protein kinase N2 increases expression ISO Nicotine results in increased expression of PKN2 mRNA CTD PMID:16949557 NCBI chr 2:234,454,001...234,559,369
Ensembl chr 2:234,454,001...234,594,649
JBrowse link
G Pla2g12a phospholipase A2, group XIIA decreases expression ISO Nicotine results in decreased expression of PLA2G12A mRNA CTD PMID:17997037 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964
JBrowse link
G Pla2g4a phospholipase A2 group 4A decreases expression EXP Nicotine results in decreased expression of PLA2G4A mRNA CTD PMID:26776438 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Plaa phospholipase A2, activating protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PLAA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PLAA mRNA] CTD PMID:20230807 NCBI chr 5:114,544,327...114,576,023
Ensembl chr 5:114,544,325...114,576,109
JBrowse link
G Plat plasminogen activator, tissue type affects expression
increases expression
multiple interactions
ISO Nicotine affects the expression of PLAT mRNA
Nicotine results in increased expression of PLAT mRNA; Nicotine results in increased expression of PLAT protein
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA
CTD PMID:11166759 PMID:17151781 PMID:18986645 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]
PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein]
CTD PMID:19690163 PMID:20061081 PMID:23825647 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]
Nicotine results in increased expression of PLAUR mRNA; Nicotine results in increased expression of PLAUR protein
CTD PMID:20061081 PMID:22261521 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Nicotine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:83,564,606...83,606,454
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Nicotine results in increased phosphorylation of and results in increased activity of PLCG1 protein CTD PMID:15138183 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050
JBrowse link
G Pld1 phospholipase D1 decreases expression ISO Nicotine results in decreased expression of PLD1 mRNA CTD PMID:18247414 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245
JBrowse link
G Pld2 phospholipase D2 increases expression ISO Nicotine results in increased expression of PLD2 mRNA CTD PMID:18247414 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 affects response to substance
decreases expression
ISO PLEKHG1 gene SNP affects the susceptibility to Nicotine
Nicotine results in decreased expression of PLEKHG1 mRNA
CTD PMID:18438686 PMID:21955143 NCBI chr 1:42,612,023...42,841,727
Ensembl chr 1:42,612,122...42,841,719
JBrowse link
G Plin2 perilipin 2 decreases expression ISO Nicotine results in decreased expression of PLIN2 protein CTD PMID:31783125 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Nicotine results in increased expression of PLK2 mRNA CTD PMID:17456735 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296
JBrowse link
G Pllp plasmolipin increases expression ISO Nicotine results in increased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,321,080...10,342,226
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Nicotine results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:25,313,070...25,323,631
Ensembl chr12:25,313,072...25,323,631
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PNMT mRNA
Nicotine results in increased expression of PNMT protein
imidacloprid promotes the reaction [Nicotine results in increased expression of PNMT protein]
CTD PMID:17498763 PMID:29246838 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,881,185...83,882,849
JBrowse link
G Pnoc prepronociceptin affects response to substance ISO PNOC protein alternative form affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr15:43,800,240...43,827,841
Ensembl chr15:43,800,246...43,827,470
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of PNPLA2 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein
CTD PMID:29155039 PMID:29617909 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359
JBrowse link
G Pnpla4 patatin like phospholipase domain containing 4 decreases expression ISO Nicotine results in decreased expression of PNPLA4 mRNA CTD PMID:16949557 NCBI chr  X:46,200,351...46,205,517
Ensembl chr  X:46,193,332...46,205,089
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:67,056,697...67,120,512
JBrowse link
G Pomc proopiomelanocortin affects response to substance
decreases expression
affects expression
multiple interactions
increases expression
ISO
EXP
POMC protein affects the susceptibility to Nicotine
Nicotine results in decreased expression of POMC protein
Nicotine affects the expression of POMC protein
POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]
Nicotine results in increased expression of POMC protein alternative form
CTD PMID:15689546 PMID:19376143 PMID:22975262 PMID:23623838 PMID:28555334 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO Nicotine results in decreased activity of PON1 protein
PON1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
CTD PMID:24478552 PMID:29747151 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Nicotine results in increased expression of PON2 mRNA CTD PMID:16949557 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996
JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO Nicotine results in decreased expression of POU2AF1 mRNA CTD PMID:18247414 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:60,436,844...60,445,176
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Nicotine results in increased expression of POU2F1 mRNA CTD PMID:18247414 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:80,663,714...80,796,356
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of POU5F1 mRNA; Nicotine results in increased expression of POU5F1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 PMID:23219715 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
JBrowse link
G Ppan peter pan homolog increases expression ISO Nicotine results in increased expression of PPAN mRNA CTD PMID:17456735 NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:27,700,152...27,704,128
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Nicotine results in decreased expression of PPARA mRNA CTD PMID:29155039 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Nicotine results in increased expression of PPARG mRNA
Nicotine results in decreased expression of PPARG protein
CTD PMID:31622651 PMID:33082140 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of PPARGC1A mRNA; Nicotine results in decreased expression of PPARGC1A protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein
CTD PMID:29155039 PMID:33091441 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PPM1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression ISO Nicotine results in increased expression of PPP2R3A mRNA CTD PMID:16949557 NCBI chr 8:110,582,479...110,720,516
Ensembl chr 8:110,583,743...110,677,482
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:78,382,849...78,406,037
Ensembl chr 6:78,382,855...78,406,201
JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta decreases expression ISO Nicotine results in decreased expression of PPP2R5D mRNA CTD PMID:17997037 NCBI chr 9:21,767,963...21,797,997
Ensembl chr 9:21,767,688...21,797,996
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO Nicotine results in decreased expression of PPP3R1 mRNA CTD PMID:21955143 NCBI chr14:95,758,333...95,808,015 JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions
decreases expression
ISO
EXP
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA
Nicotine results in decreased expression of PRDM16 mRNA
CTD PMID:33091441 NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:170,162,275...170,485,804
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRDX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PRDX3 mRNA] CTD PMID:20230807 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300
JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO Nicotine results in decreased expression of PRG4 mRNA CTD PMID:33640489 NCBI chr13:65,037,363...65,054,764
Ensembl chr13:65,037,363...65,054,508
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Nicotine results in increased expression of PRKAA2 mRNA CTD PMID:22265867 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRKAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA] CTD PMID:20230807 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression ISO Nicotine results in increased expression of PRKAR2B mRNA CTD PMID:18247414 NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:54,291,151...54,381,411
JBrowse link
G Prkca protein kinase C, alpha increases activity
increases expression
ISO
EXP
Nicotine results in increased activity of PRKCA protein
Nicotine results in increased expression of PRKCA mRNA
CTD PMID:12421819 PMID:20426880 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
JBrowse link
G Prkcb protein kinase C, beta affects localization ISO Nicotine affects the localization of PRKCB protein CTD PMID:17003101 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Nicotine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Nicotine results in increased expression of PRKCE mRNA CTD PMID:20426880 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288
JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO Nicotine results in decreased expression of PRKCSH mRNA CTD PMID:16949557 NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:28,810,889...28,822,503
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
ISO PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
Nicotine results in increased activity of PRKCZ protein
CTD PMID:17525161 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Nicotine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Prl prolactin increases secretion ISO Nicotine results in increased secretion of PRL protein CTD PMID:12893845 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Nicotine results in decreased expression of PROK1 protein CTD PMID:24368670 NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:197,537,068...197,547,550
JBrowse link
G Prom2 prominin 2 increases expression ISO Nicotine results in increased expression of PROM2 mRNA CTD PMID:23825647 NCBI chr 3:135,200,944...135,215,130
Ensembl chr 3:135,200,944...135,215,077
JBrowse link
G Prox1 prospero homeobox 1 increases expression ISO Nicotine results in increased expression of PROX1 mRNA CTD PMID:23825647 NCBI chr13:104,196,615...104,251,007
Ensembl chr13:104,200,378...104,250,975
JBrowse link
G Prpf38b pre-mRNA processing factor 38B increases expression ISO Nicotine results in increased expression of PRPF38B mRNA CTD PMID:16949557 NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:199,241,313...199,250,338
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 increases splicing ISO Nicotine results in increased splicing of PRPS1 mRNA alternative form CTD PMID:23825647 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:108,920,651...108,942,711
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Nicotine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:54,947,351...54,959,997
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO Nicotine results in increased expression of PRRC2C mRNA CTD PMID:16949557 NCBI chr13:77,537,226...77,606,926
Ensembl chr13:77,537,814...77,607,001
JBrowse link
G Prss1 serine protease 1 decreases expression ISO Nicotine results in decreased expression of PRSS1 mRNA CTD PMID:16949557 NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:71,331,246...71,334,452
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO Nicotine results in decreased expression of PSMB6 mRNA CTD PMID:18247414 NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA] CTD PMID:20230807 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:14,148,090...14,162,390
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 decreases expression ISO Nicotine results in decreased expression of PSMC4 mRNA CTD PMID:17456735 NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:92,476,690...92,485,060
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921
JBrowse link
G Psmg1 proteasome assembly chaperone 1 decreases expression ISO Nicotine results in decreased expression of PSMG1 mRNA CTD PMID:17997037 NCBI chr11:48,745,581...48,755,040
Ensembl chr11:48,745,581...48,755,040
JBrowse link
G Psmg2 proteasome assembly chaperone 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMG2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PSMG2 mRNA] CTD PMID:20230807 NCBI chr18:63,478,620...63,493,193 JBrowse link
G Ptafr platelet-activating factor receptor decreases expression
increases expression
ISO Nicotine results in decreased expression of PTAFR mRNA
Nicotine results in increased expression of PTAFR mRNA
CTD PMID:18247414 PMID:23825647 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression ISO Nicotine results in increased expression of PTBP2 mRNA CTD PMID:16949557 NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:210,497,706...210,558,291
JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO Nicotine results in decreased expression of PTGES mRNA; Nicotine results in decreased expression of PTGES protein CTD PMID:24380835 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases activity
ISO
EXP
[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of PTGS2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2]
Nicotine results in increased expression of PTGS2 mRNA; Nicotine results in increased expression of PTGS2 protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; ferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]
CTD PMID:16254210 PMID:17003101 PMID:17369603 PMID:17456735 PMID:18068289 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of PTK2 protein CTD PMID:30259641 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126
JBrowse link
G Ptx3 pentraxin 3 decreases expression ISO Nicotine results in decreased expression of PTX3 mRNA CTD PMID:18247414 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372
JBrowse link
G Pvalb parvalbumin decreases expression ISO Nicotine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PYCARD mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA]
Nicotine results in increased expression of PYCARD mRNA
CTD PMID:20230807 PMID:39098741 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
JBrowse link
G Qki QKI, KH domain containing RNA binding increases expression ISO Nicotine results in increased expression of QKI mRNA CTD PMID:17997037 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:52,935,382...53,047,337
JBrowse link
G Rab2a RAB2A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAB2 mRNA] CTD PMID:20230807 NCBI chr 5:26,473,424...26,537,441
Ensembl chr 5:26,473,548...26,538,488
JBrowse link
G Rab6a RAB6A, member RAS oncogene family decreases expression ISO Nicotine results in decreased expression of RAB6A mRNA CTD PMID:12588870 NCBI chr 1:164,370,033...164,422,324
Ensembl chr 1:164,369,861...164,417,763
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAB7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185
JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Nicotine results in increased expression of RAC2 mRNA CTD PMID:23825647 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:61,188,727...61,196,867
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression
multiple interactions
ISO Nicotine results in increased expression of RAD50 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD50 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100
JBrowse link
G Raet1e retinoic acid early transcript 1E increases expression ISO Nicotine results in increased expression of RAET1E mRNA CTD PMID:23825647 NCBI chr 1:3,474,487...3,476,431 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
affects localization
increases activity
ISO Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine affects the localization of RAF1 protein
Nicotine results in increased activity of RAF1 protein
CTD PMID:15574422 PMID:16862215 PMID:17459420 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
JBrowse link
G Ramp1 receptor activity modifying protein 1 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP1 protein CTD PMID:19910445 NCBI chr 9:99,213,031...99,263,696 JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP2 protein CTD PMID:19910445 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,688,703...86,691,231
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of RAMP3 mRNA
[Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP3 protein
CTD PMID:19910445 PMID:21955143 NCBI chr14:85,741,314...85,758,813
Ensembl chr14:85,755,211...85,758,818
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 increases expression EXP Nicotine results in increased expression of RAPGEF3 mRNA CTD PMID:11478936 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668
JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression ISO Nicotine results in decreased expression of RARG mRNA CTD PMID:18247414 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:135,246,427...135,268,889
JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:82,557,556...82,671,527
Ensembl chr16:82,557,428...82,672,984
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases phosphorylation
increases expression
decreases expression
ISO 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein]; Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine results in decreased expression of RB1 protein
CTD PMID:15574422 PMID:16011614 PMID:16601104 PMID:16862215 PMID:18448488 More... NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP4 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:146,922,611...146,959,501
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:46,464,389...46,494,244
Ensembl chr13:46,464,389...46,491,238
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]
Nicotine results in increased expression of RBBP6 mRNA
CTD PMID:12588870 PMID:16949557 NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852
JBrowse link
G Rbbp9 RB binding protein 9, serine hydrolase increases expression ISO Nicotine results in increased expression of RBBP9 mRNA CTD PMID:17997037 NCBI chr 3:152,378,426...152,392,370
Ensembl chr 3:152,378,699...152,385,489
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 decreases expression ISO Nicotine results in decreased expression of RBCK1 mRNA CTD PMID:17997037 NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:161,249,390...161,266,032
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 increases expression ISO Nicotine results in increased expression of RBFOX3 protein CTD PMID:20457658 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411
JBrowse link
G Rbm25 RNA binding motif protein 25 increases expression ISO Nicotine results in increased expression of RBM25 mRNA CTD PMID:16949557 NCBI chr 6:108,993,119...109,050,159
Ensembl chr 6:109,002,869...109,050,159
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
affects localization
decreases expression
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Nicotine affects the localization of and results in increased activity of RELA protein; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]
Nicotine affects the localization of RELA protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of RELA mRNA; Nicotine results in decreased expression of RELA protein
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Nicotine results in decreased expression of RELA protein]; Nicotine affects the localization of and results in increased activity of RELA protein
CTD PMID:16254210 PMID:17135361 PMID:18448488 PMID:23810507 PMID:27984197 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Reln reelin decreases expression EXP Nicotine results in decreased expression of RELN mRNA CTD PMID:28555334 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 decreases expression ISO Nicotine results in decreased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:31,903,972...31,908,451
Ensembl chr15:31,903,965...31,908,445
JBrowse link
G Retn resistin decreases expression EXP Nicotine results in decreased expression of RETN mRNA CTD PMID:32512034 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116
JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Nicotine results in decreased expression of RFXAP mRNA CTD PMID:12588870 NCBI chr 2:141,158,214...141,162,397
Ensembl chr 2:141,158,215...141,162,397
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Nicotine results in increased expression of RGS1 mRNA CTD PMID:18247414 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:58,568,844...58,573,187
JBrowse link
G Rgs13 regulator of G-protein signaling 13 decreases expression EXP Nicotine results in decreased expression of RGS13 mRNA CTD PMID:11478936 NCBI chr13:58,472,604...58,505,922
Ensembl chr13:58,472,604...58,505,922
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RGS2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA]
Nicotine results in increased expression of RGS2 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697
JBrowse link
G Rhob ras homolog family member B increases expression ISO Nicotine results in increased expression of RHOB mRNA CTD PMID:17997037 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772
JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA] CTD PMID:31154625 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995
JBrowse link
G Rlbp1 retinaldehyde binding protein 1 increases expression ISO Nicotine results in increased expression of RLBP1 mRNA CTD PMID:17997037 NCBI chr 1:142,718,262...142,731,621
Ensembl chr 1:142,718,262...142,731,621
JBrowse link
G Rlf RLF zinc finger increases expression ISO Nicotine results in increased expression of RLF mRNA CTD PMID:16949557 NCBI chr 5:139,996,782...140,052,419
Ensembl chr 5:139,996,782...140,052,419
JBrowse link
G Rnd3 Rho family GTPase 3 increases splicing ISO Nicotine results in increased splicing of RND3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536
JBrowse link
G Rnf145 ring finger protein 145 decreases expression ISO Nicotine results in decreased expression of RNF145 mRNA CTD PMID:17456735 NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,507,772...29,552,151
JBrowse link
G Rph3a rabphilin 3A increases expression ISO Nicotine results in increased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:41,203,004...41,279,536
Ensembl chr12:41,200,089...41,279,531
JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:54,109,692...54,112,822
Ensembl chr10:54,109,362...54,112,822
JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225
JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO Nicotine results in decreased expression of RPL7A mRNA CTD PMID:18247414 NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791
JBrowse link
G Rps24 ribosomal protein S24 increases splicing ISO Nicotine results in increased splicing of RPS24 mRNA alternative form CTD PMID:23825647 NCBI chr16:95,429...101,146
Ensembl chr16:96,484...101,144
JBrowse link
G Rps25 ribosomal protein s25 increases expression ISO Nicotine results in increased expression of RPS25 mRNA CTD PMID:18247414 NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:53,629,861...53,632,808
Ensembl chr 8:53,629,861...53,632,808
JBrowse link
G Rps27a ribosomal protein S27a multiple interactions
decreases expression
ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr14:107,486,664...107,488,941
Ensembl chr 5:138,465,088...138,466,080
Ensembl chr14:138,465,088...138,466,080
Ensembl chr 5:138,465,088...138,466,080
JBrowse link
G Rps5 ribosomal protein S5 decreases expression ISO Nicotine results in decreased expression of RPS5 mRNA CTD PMID:33640489 NCBI chr 1:82,610,965...82,615,262
Ensembl chr 1:82,610,965...82,615,262
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
ISO Cholesterol inhibits the reaction [Nicotine results in increased phosphorylation of RPS6 protein] CTD PMID:31629012 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of RPS6KB1 protein; dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]
Nicotine results in increased phosphorylation of RPS6KB1 protein
CTD PMID:30259641 PMID:31926917 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases expression EXP Nicotine results in decreased expression of RPS6KB2 mRNA CTD PMID:11478936 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:210,880,825...210,887,562
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 affects response to substance ISO RPTOR gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of RSAD2 mRNA CTD PMID:37951547 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320
JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:30,112,529...30,197,267
Ensembl chr 1:30,112,114...30,197,938
JBrowse link
G RT1-Bb RT1 class II, locus Bb multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DQB1 mRNA CTD PMID:37951547 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 multiple interactions ISO Nicotine promotes the reaction [nickel chloride results in increased expression of HLA-F mRNA] CTD PMID:37951547 NCBI chr20:3,407,880...3,484,130 JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRA mRNA CTD PMID:37951547 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRB1 mRNA CTD PMID:37951547 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO Nicotine results in decreased expression of RUNX1T1 mRNA CTD PMID:18247414 NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:31,984,855...32,132,855
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases expression
ISO
EXP
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]
Nicotine results in increased expression of RYR2 mRNA; Nicotine results in increased expression of RYR2 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]
CTD PMID:21113126 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Nicotine results in decreased expression of S100A10 mRNA CTD PMID:18247414 NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:181,904,261...181,913,103
JBrowse link
G S100a14 S100 calcium binding protein A14 increases expression ISO Nicotine results in increased expression of S100A14 mRNA CTD PMID:23825647 NCBI chr 2:178,305,976...178,308,004
Ensembl chr 2:178,306,025...178,307,999
JBrowse link
G S100a2 S100 calcium binding protein A2 increases expression ISO Nicotine results in increased expression of S100A2 mRNA CTD PMID:23825647 NCBI chr 2:178,374,659...178,375,903 JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Nicotine results in decreased expression of S100A6 mRNA CTD PMID:33640489 NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Nicotine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Nicotine results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689
JBrowse link
G Sap30l SAP30-like decreases expression ISO Nicotine results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:42,480,201...42,488,139
Ensembl chr10:42,480,201...42,488,139
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO Nicotine results in increased expression of SAR1B mRNA CTD PMID:17997037 NCBI chr10:36,525,365...36,555,009
Ensembl chr10:36,519,384...36,555,005
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Nicotine results in increased expression of SC5D mRNA CTD PMID:17456735 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277
JBrowse link
G Scaf11 SR-related CTD-associated factor 11 increases expression ISO Nicotine results in increased expression of SCAF11 mRNA CTD PMID:16949557 NCBI chr 7:129,450,872...129,503,280
Ensembl chr 7:129,417,955...129,503,280
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]
Nicotine results in decreased expression of SCARB1 mRNA; Nicotine results in decreased expression of SCARB1 protein
CTD PMID:30036686 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Nicotine results in increased expression of SCD1 mRNA
Nicotine results in increased expression of SCD mRNA
CTD PMID:17997037 PMID:23825647 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
JBrowse link
G Scg2 secretogranin II increases expression EXP Nicotine results in increased expression of SCG2 mRNA CTD PMID:1907749 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Nicotine results in increased expression of SDC4 mRNA CTD PMID:21955143 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670
JBrowse link
G Sec61g Sec61 translocon subunit gamma increases expression ISO Nicotine results in increased expression of SEC61G mRNA CTD PMID:16949557 NCBI chr14:95,113,083...95,119,458
Ensembl chr 9:48,798,504...48,798,710
Ensembl chr14:48,798,504...48,798,710
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SENP6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:89,868,115...89,951,803
Ensembl chr 8:89,868,867...89,948,062
JBrowse link
G Septin7 septin 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:31,995,005...32,059,072
JBrowse link
G Septin8 septin 8 decreases expression ISO Nicotine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504
JBrowse link
G Serinc3 serine incorporator 3 increases expression ISO Nicotine results in increased expression of SERINC3 mRNA CTD PMID:16949557 NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:172,721,321...172,740,765
JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Nicotine results in increased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166
JBrowse link
G Serpine1 serpin family E member 1 increases secretion
increases expression
EXP
ISO
Nicotine results in increased secretion of SERPINE1 protein
Nicotine results in increased expression of SERPINE1 mRNA
CTD PMID:11166759 PMID:21596853 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Nicotine results in decreased expression of SERPINF1 mRNA
Nicotine results in decreased expression of SERPINF1 mRNA; Nicotine results in decreased expression of SERPINF1 protein
CTD PMID:21955143 PMID:26536586 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression ISO Nicotine results in decreased expression of SERPINH1 mRNA CTD PMID:16949557 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976
JBrowse link
G Sertad4 SERTA domain containing 4 decreases expression ISO Nicotine results in decreased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:106,889,019...106,899,777
Ensembl chr13:106,889,019...106,900,309
JBrowse link
G Sf3b6 splicing factor 3B, subunit 6 increases expression ISO Nicotine results in increased expression of SF3B6 mRNA CTD PMID:16949557 NCBI chr 6:33,545,495...33,554,537
Ensembl chr 6:33,545,512...33,554,608
JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Nicotine results in increased expression of SFPQ mRNA
CTD PMID:17997037 PMID:20230807 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926
JBrowse link
G Sftpa1 surfactant protein A1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPA1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]
CTD PMID:9458815 NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,042,255...17,045,769
JBrowse link
G Sftpc surfactant protein C increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPC mRNA
[Nicotine co-treated with Quartz] results in increased expression of SFTPC protein; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]
CTD PMID:9458815 PMID:36868510 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Nicotine results in increased expression of SGK1 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Nicotine results in decreased expression of SGPP1 mRNA CTD PMID:17997037 NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:100,161,024...100,182,259
JBrowse link
G Sh2d2a SH2 domain containing 2A increases expression ISO Nicotine results in increased expression of SH2D2A mRNA CTD PMID:23825647 NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:175,609,874...175,616,685
JBrowse link
G Sh3d19 SH3 domain containing 19 increases splicing ISO Nicotine results in increased splicing of SH3D19 mRNA alternative form CTD PMID:23825647 NCBI chr 2:173,654,234...173,814,030
Ensembl chr 2:173,654,420...173,814,025
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Nicotine results in increased expression of SH3KBP1 mRNA CTD PMID:23825647 NCBI chr  X:38,686,530...39,031,658
Ensembl chr  X:38,686,530...39,031,393
JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO Nicotine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:153,524,324...153,537,571
Ensembl chr 2:153,527,571...153,537,161
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 protein; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of CXCL8 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]
resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA]
CTD PMID:22687363 PMID:23199342 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression ISO Nicotine results in decreased expression of SIVA1 mRNA CTD PMID:16949557 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790
JBrowse link
G Slbp stem-loop histone mRNA binding protein decreases expression
multiple interactions
ISO Nicotine results in decreased expression of SLBP mRNA; Nicotine results in decreased expression of SLBP protein
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; Roscovitine inhibits the reaction [Nicotine results in decreased expression of SLBP protein]
CTD PMID:35929799 NCBI chr14:81,295,479...81,306,446
Ensembl chr14:81,296,223...81,306,447
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO
EXP
Nicotine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 PMID:28555334 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498
JBrowse link
G Slc18a3 solute carrier family 18 member A3 multiple interactions EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of SLC18A3 protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of SLC18A3 protein] CTD PMID:20361958 PMID:22119111 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Nicotine results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of SLC1A1 protein
Tetradecanoylphorbol Acetate inhibits the reaction [Nicotine results in decreased activity of SLC1A1 protein]
CTD PMID:24355585 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
affects response to substance
ISO Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
SLC22A2 gene SNP affects the susceptibility to Nicotine
CTD PMID:23770354 PMID:25143296 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc25a48 solute carrier family 25, member 48 decreases expression ISO Nicotine results in decreased expression of SLC25A48 mRNA CTD PMID:23825647 NCBI chr17:8,113,134...8,172,376
Ensembl chr17:8,127,111...8,166,042
JBrowse link
G Slc35a1 solute carrier family 35 member A1 increases expression ISO Nicotine results in increased expression of SLC35A1 mRNA CTD PMID:16949557 NCBI chr 5:54,021,896...54,044,677
Ensembl chr 5:54,021,896...54,044,677
JBrowse link
G Slc37a2 solute carrier family 37 member 2 increases expression ISO Nicotine results in increased expression of SLC37A2 mRNA CTD PMID:23825647 NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:45,134,596...45,277,989
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO Nicotine results in increased expression of SLC39A6 mRNA CTD PMID:16949557 NCBI chr18:16,139,621...16,160,163
Ensembl chr18:16,135,008...16,160,163
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Nicotine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions EXP Nicotine affects the reaction [Hemicholinium 3 binds to SLC5A7 protein] CTD PMID:21633116 NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,922,697...7,953,509
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases methylation
decreases activity
ISO
EXP
Nicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]
Nicotine results in decreased expression of SLC6A3 mRNA; Nicotine results in decreased expression of SLC6A3 protein
Nicotine results in increased methylation of SLC6A3 promoter
Nicotine results in decreased activity of SLC6A3 protein
Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]; Mecamylamine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]
CTD PMID:17227438 PMID:23999947 PMID:31945395 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Nicotine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:56,718,849...56,737,702
Ensembl chr18:56,718,849...56,737,702
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Nicotine results in increased expression of SLC7A5 mRNA CTD PMID:23825647 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 increases expression ISO Nicotine results in increased expression of SLCO2A1 mRNA CTD PMID:23825647 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921
JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957
JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Nicotine results in decreased expression of SMAD2 mRNA; Nicotine results in decreased expression of SMAD2 protein CTD PMID:29660438 PMID:31299270 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein
Nicotine results in decreased expression of SMAD3 mRNA
CTD PMID:20230807 PMID:22691361 PMID:29660438 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324
JBrowse link
G Smad9 SMAD family member 9 increases expression ISO Nicotine results in increased expression of SMAD9 mRNA CTD PMID:18247414 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMPD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936
JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions
increases response to substance
ISO
EXP
Nicotine results in increased expression of SNAI1 mRNA; Nicotine results in increased expression of SNAI1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
SNAI1 results in increased susceptibility to Nicotine
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:23219715 PMID:34245815 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of SNAI2 mRNA
Nicotine results in decreased expression of SNAI2 mRNA
CTD PMID:20339300 PMID:23219715 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349
JBrowse link
G Snapc3 small nuclear RNA activating complex, polypeptide 3 increases expression ISO Nicotine results in increased expression of SNAPC3 mRNA CTD PMID:16949557 NCBI chr 5:102,863,867...102,890,573
Ensembl chr 5:102,863,854...102,893,499
JBrowse link
G Snca synuclein alpha increases expression ISO Nicotine results in increased expression of SNCA mRNA CTD PMID:18247414 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Sncg synuclein, gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SNCG mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCG mRNA] CTD PMID:20230807 NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,706,753...9,712,076
JBrowse link
G Snord8 small nucleolar RNA, C/D box 8 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of SNORD8 mRNA CTD PMID:28065790 NCBI chr15:27,391,331...27,391,440
Ensembl chr15:27,391,331...27,391,440
JBrowse link
G Snrk SNF related kinase decreases expression ISO Nicotine results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:130,657,204...130,711,461
Ensembl chr 8:130,657,266...130,711,457
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Nicotine results in increased expression of SOCS3 mRNA CTD PMID:29155039 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SOD1 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein
CTD PMID:16627626 PMID:29617909 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in decreased expression of SOD2 protein
SOD2 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of SOD2 protein]
Nicotine results in increased expression of SOD2 protein
CTD PMID:18343235 PMID:22687363 PMID:28681937 PMID:29617909 PMID:29747151 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] CTD PMID:16949557 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350
JBrowse link
G Sost sclerostin increases expression ISO Nicotine results in increased expression of SOST mRNA CTD PMID:33640489 NCBI chr10:87,412,722...87,415,766
Ensembl chr10:87,411,721...87,415,766
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A decreases expression ISO Nicotine results in decreased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:38,142,633...38,146,199
Ensembl chr10:38,144,782...38,147,171
JBrowse link
G Sox18 SRY-box transcription factor 18 decreases expression ISO Nicotine results in decreased expression of SOX18 mRNA CTD PMID:17456735 NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:189,163,002...189,164,802
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Nicotine results in decreased expression of SOX9 mRNA; Nicotine results in decreased expression of SOX9 protein CTD PMID:29660438 PMID:31299270 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein] CTD PMID:24089524 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513
JBrowse link
G Spag9 sperm associated antigen 9 increases expression ISO Nicotine results in increased expression of SPAG9 mRNA CTD PMID:16949557 NCBI chr10:79,440,311...79,574,709
Ensembl chr10:79,440,377...79,575,258
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SPP1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]
CTD PMID:11425648 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Sprr2d small proline-rich protein 2D increases expression ISO Nicotine results in increased expression of SPRR2D mRNA CTD PMID:23825647 NCBI chr 2:180,565,685...180,566,282
Ensembl chr 2:180,566,007...180,567,002
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 increases expression ISO Nicotine results in increased expression of SPTLC3 mRNA CTD PMID:23825647 NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:147,301,801...147,434,044
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]
Nicotine results in increased expression of SQSTM1 protein
CTD PMID:31926917 PMID:33010382 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions
ISO Nicotine results in increased phosphorylation of SRC protein
ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein]; Nicotine results in increased phosphorylation of and results in increased activity of SRC protein; RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
CTD PMID:14569062 PMID:16862215 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SREBF1 mRNA
Nicotine results in increased expression of SREBF1 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA
CTD PMID:18247414 PMID:29155039 PMID:29617909 PMID:31622651 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO Nicotine results in decreased expression of SRGAP2 mRNA CTD PMID:17997037 NCBI chr13:45,298,192...45,519,330
Ensembl chr13:45,298,192...45,519,330
JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:96,364,253...96,372,393
Ensembl chr13:96,364,298...96,373,257
JBrowse link
G Srpx2 sushi-repeat-containing protein, X-linked 2 increases expression ISO Nicotine results in increased expression of SRPX2 mRNA CTD PMID:23825647 NCBI chr  X:101,399,748...101,425,486
Ensembl chr  X:101,399,853...101,425,484
JBrowse link
G Sst somatostatin decreases expression ISO Nicotine results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 decreases expression ISO Nicotine results in decreased expression of ST8SIA3 mRNA CTD PMID:21955143 NCBI chr18:60,024,555...60,031,050
Ensembl chr18:60,024,236...60,032,473
JBrowse link
G Stac SH3 and cysteine rich domain increases expression ISO Nicotine results in increased expression of STAC mRNA CTD PMID:23825647 NCBI chr 8:120,409,165...120,531,394
Ensembl chr 8:120,409,165...120,531,320
JBrowse link
G Star steroidogenic acute regulatory protein increases methylation
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased methylation of STAR promoter
Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Taurine inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Taurine inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Nicotine results in decreased expression of STAR; Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]
CTD PMID:20498001 PMID:21971485 PMID:22265867 PMID:24709674 PMID:31846720 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA] CTD PMID:31154625 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO Nicotine results in decreased expression of STAT2 mRNA CTD PMID:18247414 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:1,287,024...1,303,459
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
affects expression
increases response to substance
increases activity
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Cisplatin results in decreased activity of STAT3 protein]; Nicotine inhibits the reaction [Paclitaxel results in decreased activity of STAT3 protein]; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; Nicotine results in increased phosphorylation of and results in increased activity of STAT3 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; U 0126 inhibits the reaction [Nicotine results in increased activity of STAT3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form; Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]
Nicotine affects the expression of STAT3 mRNA
STAT3 protein results in increased susceptibility to Nicotine
HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Quartz results in decreased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased phosphorylation of STAT3 protein]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
STAT3 results in increased susceptibility to Nicotine
CTD PMID:18448488 PMID:20106947 PMID:20943775 PMID:21606497 PMID:24095726 More... NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases phosphorylation
multiple interactions
ISO Nicotine results in decreased phosphorylation of STAT5 protein
Cholesterol inhibits the reaction [Nicotine results in decreased phosphorylation of STAT5 protein]
CTD PMID:31629012 PMID:31783125 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression ISO Nicotine results in increased expression of STAT5B mRNA CTD PMID:18805435 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO Nicotine results in increased expression of STAT6 mRNA CTD PMID:18805435 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Nicotine results in increased expression of STC2 mRNA CTD PMID:16949557 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447
JBrowse link
G Steap1 STEAP family member 1 increases expression ISO Nicotine results in increased expression of STEAP1 mRNA CTD PMID:23825647 NCBI chr 4:29,231,809...29,242,317
Ensembl chr 4:29,231,753...29,242,317
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of STIP1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STIP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654
JBrowse link
G Stk25 serine/threonine kinase 25 increases expression ISO Nicotine results in increased expression of STK25 mRNA CTD PMID:18247414 NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:101,609,221...101,621,359
JBrowse link
G Strip2 striatin interacting protein 2 decreases expression ISO Nicotine results in decreased expression of STRIP2 mRNA CTD PMID:21955143 NCBI chr 4:59,503,478...59,545,745
Ensembl chr 4:59,503,481...59,545,739
JBrowse link
G Stx4 syntaxin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STX4A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STX4A mRNA] CTD PMID:20230807 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774
JBrowse link
G Stxbp3 syntaxin binding protein 3 increases expression ISO Nicotine results in increased expression of STXBP3 mRNA CTD PMID:16949557 NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:199,130,725...199,173,823
JBrowse link
G Sub1 SUB1 regulator of transcription increases expression ISO Nicotine results in increased expression of SUB1 mRNA CTD PMID:17456735 NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:62,732,736...62,747,679
JBrowse link
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit decreases expression ISO Nicotine results in decreased expression of SUPT4H1 mRNA CTD PMID:18247414 NCBI chr10:73,036,560...73,042,821
Ensembl chr10:73,036,343...73,043,088
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO Nicotine results in decreased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721
JBrowse link
G Syngr2 synaptogyrin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SYNGR2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SYNGR2 mRNA] CTD PMID:20230807 NCBI chr10:103,528,599...103,533,167
Ensembl chr10:103,528,607...103,533,162
JBrowse link
G Synpo synaptopodin increases expression ISO Nicotine results in increased expression of SYNPO mRNA CTD PMID:23825647 NCBI chr18:56,326,369...56,347,359
Ensembl chr18:56,319,571...56,353,306
JBrowse link
G Syt3 synaptotagmin 3 increases methylation EXP Nicotine results in increased methylation of SYT3 gene CTD PMID:32994467 NCBI chr 1:104,017,341...104,032,046
Ensembl chr 1:104,017,379...104,032,045
JBrowse link
G Syt4 synaptotagmin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SYT4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SYT4 mRNA] CTD PMID:20230807 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Nicotine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:170,687,606...170,881,375
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases methylation EXP Nicotine results in decreased methylation of TAB1 gene CTD PMID:35026373 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:113,555,819...113,587,351
JBrowse link
G Tacr1 tachykinin receptor 1 decreases expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of TACR1 mRNA; Nicotine results in decreased expression of TACR1 protein
Nicotine results in increased expression of TACR1 mRNA; Nicotine results in increased expression of TACR1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]
CTD PMID:26524655 PMID:27329243 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492
JBrowse link
G Tada2b transcriptional adaptor 2B increases expression EXP Nicotine results in increased expression of TADA2B mRNA CTD PMID:27782041 NCBI chr14:78,503,939...78,523,715
Ensembl chr14:78,503,644...78,515,436
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Nicotine results in decreased expression of TAGLN2 mRNA CTD PMID:16949557 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330
JBrowse link
G Taok1 TAO kinase 1 increases expression ISO Nicotine results in increased expression of TAOK1 mRNA CTD PMID:16949557 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,871,198...62,957,595
JBrowse link
G Tbxa2r thromboxane A2 receptor increases activity EXP Nicotine results in increased activity of TBXA2R protein CTD PMID:21316381 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases splicing ISO Nicotine results in increased splicing of TENT4A mRNA alternative form CTD PMID:23825647 NCBI chr 1:35,594,380...35,627,836
Ensembl chr 1:35,594,380...35,627,836
JBrowse link
G Tex264 testis expressed 264, ER-phagy receptor decreases expression ISO Nicotine results in decreased expression of TEX264 mRNA CTD PMID:17997037 NCBI chr 8:116,174,517...116,201,578
Ensembl chr 8:116,174,518...116,201,667
JBrowse link
G Tf transferrin multiple interactions ISO [Nicotine co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein CTD PMID:36372912 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tfdp1 transcription factor Dp-1 multiple interactions
increases expression
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein]
Nicotine results in increased expression of TFDP1 mRNA
Nicotine results in decreased expression of TFDP1 mRNA
CTD PMID:17997037 PMID:18247414 PMID:20061081 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]
Nicotine results in increased expression of TFPI2 mRNA
CTD PMID:12588870 NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426
JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions
ISO Nicotine results in increased expression of TFRC mRNA
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]
CTD PMID:16949557 PMID:20230807 PMID:28065790 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
affects expression
increases expression
ISO
EXP
Nicotine results in decreased expression of TGFB1 mRNA
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Nicotine affects the expression of TGFB1 mRNA
Nicotine results in increased expression of TGFB1 mRNA
Nicotine results in increased expression of TGFB1 protein
Nicotine results in decreased expression of TGFB1 mRNA; Nicotine results in decreased expression of TGFB1 protein
CTD PMID:21237301 PMID:22691361 PMID:25280790 PMID:29660438 PMID:31299270 More... NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Nicotine results in decreased expression of TGFBR1 mRNA; Nicotine results in decreased expression of TGFBR1 protein CTD PMID:29660438 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression EXP Nicotine results in decreased expression of TGFBR2 mRNA CTD PMID:28555334 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of TH mRNA; Nicotine results in increased expression of TH protein
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; conotoxin AuIB inhibits the reaction [Nicotine results in increased expression of TH mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of TH mRNA]; ZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; ZM 241385 inhibits the reaction [Nicotine results in increased expression of TH mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TH mRNA; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
CTD PMID:17498763 PMID:19594327 PMID:20230807 PMID:23933227 PMID:28082123 More... NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Thoc1 THO complex subunit 1 increases expression ISO Nicotine results in increased expression of THOC1 mRNA CTD PMID:16949557 NCBI chr18:1,253,041...1,291,956
Ensembl chr18:1,256,637...1,292,630
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression
increases expression
multiple interactions
ISO
EXP
Nicotine affects the expression of TIMP1 mRNA
Nicotine results in increased expression of TIMP1 mRNA
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP1 mRNA
CTD PMID:18986645 PMID:34153408 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Nicotine results in increased expression of TIMP2 mRNA CTD PMID:34153408 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects expression
multiple interactions
ISO Nicotine affects the expression of TIMP3 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA
CTD PMID:18986645 PMID:20230807 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 multiple interactions
decreases expression
affects expression
ISO
EXP
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP4 mRNA
Nicotine results in decreased expression of TIMP4 protein
Nicotine affects the expression of TIMP4 mRNA
CTD PMID:18986645 PMID:28681937 NCBI chr 4:149,978,667...149,985,350
Ensembl chr 4:149,978,685...149,985,452
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression ISO Nicotine results in increased expression of TINAGL1 mRNA CTD PMID:23825647 NCBI chr 5:147,797,884...147,807,925
Ensembl chr 5:147,797,892...147,807,871
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Nicotine results in increased expression of TIPARP mRNA CTD PMID:17456735 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406
JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA] CTD PMID:20230807 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD PMID:18844224 PMID:20722969 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA]
[Aerosols co-treated with Nicotine] results in increased expression of TLR4 mRNA
CTD PMID:27984197 PMID:33469865 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO Nicotine results in increased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:30,781,452...31,058,888
Ensembl chr 7:30,897,991...31,058,889
JBrowse link
G Tmem125 transmembrane protein 125 increases expression ISO Nicotine results in increased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:137,348,545...137,349,949
Ensembl chr 5:137,345,202...137,351,952
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Nicotine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:41,520,595...41,693,938
Ensembl chr13:41,520,359...41,693,938
JBrowse link
G Tmem222 transmembrane protein 222 increases splicing ISO Nicotine results in increased splicing of TMEM222 mRNA alternative form CTD PMID:23825647 NCBI chr 5:150,749,746...150,763,031
Ensembl chr 5:150,749,748...150,767,278
JBrowse link
G Tmem41b transmembrane protein 41B increases expression ISO Nicotine results in increased expression of TMEM41B mRNA CTD PMID:16949557 NCBI chr 1:173,447,362...173,461,760
Ensembl chr 1:173,447,367...173,461,597
JBrowse link
G Tmem63a transmembrane protein 63a increases expression ISO Nicotine results in increased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:95,194,323...95,227,944
Ensembl chr13:95,195,234...95,228,302
JBrowse link
G Tmem97 transmembrane protein 97 increases expression ISO Nicotine results in increased expression of TMEM97 mRNA CTD PMID:17997037 NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,936,271...63,945,818
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
increases secretion
decreases expression
increases expression
increases degradation
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
Nicotine affects the expression of TNF mRNA
Nicotine results in increased secretion of TNF protein
Nicotine results in decreased expression of TNF protein
Nicotine results in increased expression of TNF mRNA; Nicotine results in increased expression of TNF protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; erdosteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TNF mRNA]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Nicotine results in increased expression of TNF protein]
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:15135227 PMID:16254210 PMID:17216608 PMID:20426880 PMID:21237301 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions
EXP Nicotine results in increased expression of TNFRSF11B mRNA
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]
CTD PMID:29981921 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression
decreases expression
EXP
ISO
Nicotine results in increased expression of TNFRSF1A mRNA
Nicotine results in decreased expression of TNFRSF1A mRNA
CTD PMID:18247414 PMID:20426880 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases expression
EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA] CTD PMID:29981921 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TNK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNK2 mRNA] CTD PMID:20230807 NCBI chr11:81,619,795...81,659,074
Ensembl chr11:81,619,796...81,659,074
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 increases expression ISO Nicotine results in increased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:56,847,837...56,886,302
Ensembl chr11:56,846,334...56,886,320
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 increases expression ISO Nicotine results in increased expression of TOPBP1 mRNA CTD PMID:16949557 NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:112,766,508...112,810,540
JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions
affects response to substance
affects expression
ISO
EXP
Nicotine results in decreased expression of TP53 mRNA; Nicotine results in decreased expression of TP53 protein
Nicotine results in increased expression of TRP53 mRNA; Nicotine results in increased expression of TRP53 protein
Nicotine results in decreased expression of TRP53 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA]
Nicotine results in increased expression of TP53 mRNA
TP53 protein affects the susceptibility to Nicotine
Nicotine affects the expression of TP53 mRNA
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of TP53 protein]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
Nicotine results in increased expression of TP53 protein
CTD PMID:10837795 PMID:15983034 PMID:16011614 PMID:16601104 PMID:18247414 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Nicotine] results in increased expression of TRP53INP1 mRNA CTD PMID:20230807 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA] CTD PMID:20230807 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639
JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPP2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPP2 mRNA] CTD PMID:20230807 NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:53,538,313...53,620,251
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Nicotine results in increased expression of TPR mRNA CTD PMID:16949557 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602
JBrowse link
G Tra2a transformer 2 alpha increases expression ISO Nicotine results in increased expression of TRA2A mRNA CTD PMID:16949557 NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:79,551,542...79,570,619
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 increases expression ISO Nicotine results in increased expression of TREM1 mRNA CTD PMID:23825647 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892
JBrowse link
G Trib2 tribbles pseudokinase 2 increases expression ISO Nicotine results in increased expression of TRIB2 mRNA CTD PMID:16949557 NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:44,274,762...44,299,094
JBrowse link
G Trim28 tripartite motif-containing 28 increases splicing ISO Nicotine results in increased splicing of TRIM28 mRNA alternative form CTD PMID:23825647 NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572
JBrowse link
G Trip11 thyroid hormone receptor interactor 11 increases expression ISO Nicotine results in increased expression of TRIP11 mRNA CTD PMID:16949557 NCBI chr 6:126,760,263...126,832,619
Ensembl chr 6:126,760,265...126,832,570
JBrowse link
G Trnp1 TMF1-regulated nuclear protein 1 increases expression ISO Nicotine results in increased expression of TRNP1 mRNA CTD PMID:23825647 NCBI chr 5:150,990,312...150,997,148
Ensembl chr 5:150,989,973...150,997,277
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects response to substance
increases expression
increases activity
EXP Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]
TRPV1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of TRPV1 mRNA; Nicotine results in increased expression of TRPV1 protein
Nicotine results in increased activity of TRPV1 protein
CTD PMID:19483072 PMID:26524655 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TSC22D1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TSC22D1 mRNA] CTD PMID:20230807 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322
JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression ISO Nicotine results in increased expression of TSHR mRNA CTD PMID:18247414 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Nicotine results in decreased expression of TUBA4A mRNA CTD PMID:16949557 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Nicotine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:2,004,836...2,012,281
Ensembl chr 9:2,004,840...2,012,286
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Nicotine results in decreased expression of TUBB mRNA CTD PMID:16949557 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression ISO Nicotine results in increased expression of TUT4 mRNA CTD PMID:16949557 NCBI chr 5:128,354,975...128,535,288
Ensembl chr 5:128,431,719...128,535,656
JBrowse link
G Twf2 twinfilin actin-binding protein 2 decreases expression ISO Nicotine results in decreased expression of TWF2 mRNA CTD PMID:17997037 NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:115,723,970...115,737,025
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of TWIST1 mRNA
Nicotine promotes the reaction [Quartz results in increased expression of TWIST1 protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of TWIST1 protein]
CTD PMID:23219715 PMID:36868510 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965
JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of TXN1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TXN1 protein]
CTD PMID:28082123 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO Nicotine results in increased expression of TXNDC9 mRNA CTD PMID:16949557 NCBI chr 9:47,707,628...47,717,761
Ensembl chr 9:47,707,231...47,880,085
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Nicotine results in increased expression of TXNIP mRNA CTD PMID:17456735 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases expression ISO Nicotine results in increased expression of U2SURP mRNA CTD PMID:16949557 NCBI chr 8:104,898,580...104,963,642
Ensembl chr 8:104,898,425...104,955,422
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of UBA2 protein
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901
JBrowse link
G Ubb ubiquitin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA] CTD PMID:20230807 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,727,701...47,750,335
JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA] CTD PMID:20230807 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of UBE2C mRNA
Nicotine results in decreased expression of UBE2C mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
CTD PMID:16949557 PMID:23825647 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UBE2D2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBE2D2 mRNA] CTD PMID:20230807 NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,638,527...27,683,074
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Nicotine results in decreased expression of UBE2I mRNA CTD PMID:18247414 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866
JBrowse link
G Ube3a ubiquitin protein ligase E3A multiple interactions
decreases expression
ISO Mecamylamine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]; Nicotine inhibits the reaction [alpha-cobratoxin results in decreased expression of UBE3A mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] CTD PMID:12588870 NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA] CTD PMID:20230807 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417
JBrowse link
G Ucp1 uncoupling protein 1 decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of UCP1 mRNA; Nicotine results in decreased expression of UCP1 protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein
CTD PMID:33091441 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420
JBrowse link
G Ufm1 ubiquitin-fold modifier 1 increases expression ISO Nicotine results in increased expression of UFM1 mRNA CTD PMID:16949557 NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:140,119,725...140,127,866
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO Nicotine results in increased expression of UGP2 mRNA CTD PMID:18247414 NCBI chr14:99,657,637...99,698,573
Ensembl chr14:99,657,639...99,698,002
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
decreases expression
ISO UGT1A4 protein results in increased glucuronidation of Nicotine
Nicotine results in decreased expression of UGT1A5 mRNA
CTD PMID:14570768 PMID:16141602 PMID:21955143 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 PMID:16141602 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Unc119 unc-119 lipid binding chaperone decreases expression ISO Nicotine results in decreased expression of UNC119 mRNA CTD PMID:16949557 NCBI chr10:63,735,927...63,741,404
Ensembl chr10:63,735,777...63,741,404
JBrowse link
G Unc45b unc-45 myosin chaperone B decreases expression EXP Nicotine results in decreased expression of UNC45B mRNA CTD PMID:27782041 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980
JBrowse link
G Unc5b unc-5 netrin receptor B increases expression ISO Nicotine results in increased expression of UNC5B mRNA CTD PMID:23825647 NCBI chr20:29,240,639...29,307,270
Ensembl chr20:29,240,650...29,307,270
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Nicotine results in increased expression of UPP1 mRNA CTD PMID:23825647 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:88,023,351...88,043,034
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP Nicotine results in decreased expression of UQCRC2 protein CTD PMID:28681937 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression ISO Nicotine results in decreased expression of UQCRFS1 mRNA CTD PMID:18247414 NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950
JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Nicotine results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:99,783,157...99,845,787
Ensembl chr 1:99,783,158...99,853,906
JBrowse link
G Uros uroporphyrinogen III synthase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UROS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UROS mRNA] CTD PMID:20230807 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:197,921,701...197,936,150
JBrowse link
G Vamp4 vesicle-associated membrane protein 4 increases expression ISO Nicotine results in increased expression of VAMP4 mRNA CTD PMID:17997037 NCBI chr13:77,453,135...77,475,909
Ensembl chr13:77,453,121...77,476,024
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of VCAM1 mRNA CTD PMID:11166759 PMID:16254210 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vcan versican increases expression ISO Nicotine results in increased expression of VCAN mRNA CTD PMID:23825647 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
decreases expression
increases secretion
affects response to substance
decreases secretion
ISO
EXP
Nicotine results in increased expression of VEGFA mRNA; Nicotine results in increased expression of VEGFA protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
Nicotine results in decreased expression of VEGFA protein
Nicotine results in increased secretion of VEGFA protein
Nicotine affects the susceptibility to VEGFA
Nicotine results in decreased secretion of VEGFA protein
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]
CTD PMID:14569062 PMID:16499655 PMID:20426880 PMID:20457658 PMID:21378373 More... NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of VIM mRNA
Nicotine promotes the reaction [Quartz results in increased expression of VIM protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of VIM protein]
Nicotine results in increased expression of VIM mRNA; Nicotine results in increased expression of VIM protein
CTD PMID:18247414 PMID:18844224 PMID:23219715 PMID:36868510 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Vps28 VPS28 subunit of ESCRT-I multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS28 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of VPS28 mRNA] CTD PMID:20230807 NCBI chr 7:110,222,638...110,226,486
Ensembl chr 7:110,222,638...110,225,569
JBrowse link
G Vps41 VPS41 subunit of HOPS complex multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS41 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of VPS41 mRNA] CTD PMID:20230807 NCBI chr17:50,758,732...50,923,129
Ensembl chr17:50,758,734...50,923,133
JBrowse link
G Vrk2 VRK serine/threonine kinase 2 decreases expression ISO Nicotine results in decreased expression of VRK2 mRNA CTD PMID:23825647 NCBI chr14:104,514,815...104,635,549
Ensembl chr14:104,514,100...104,720,933
JBrowse link
G Vwf von Willebrand factor increases expression
decreases expression
ISO Nicotine results in increased expression of VWF mRNA
Nicotine results in decreased expression of VWF mRNA
CTD PMID:11166759 PMID:17456735 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757
JBrowse link
G Wbp4 WW domain binding protein 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of WBP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of WBP4 mRNA] CTD PMID:20230807 NCBI chr15:61,271,774...61,299,740
Ensembl chr15:61,271,783...61,299,740
JBrowse link
G Wnt4 Wnt family member 4 multiple interactions
increases expression
ISO Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 protein]
Nicotine results in increased expression of WNT4 mRNA; Nicotine results in increased expression of WNT4 protein
CTD PMID:33640489 PMID:35411647 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128
JBrowse link
G Wnt7b Wnt family member 7B increases expression ISO Nicotine results in increased expression of WNT7B mRNA CTD PMID:23825647 NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:118,514,684...118,559,316
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of XAF1 mRNA CTD PMID:37951547 NCBI chr10:57,415,935...57,428,348
Ensembl chr10:57,415,658...57,428,349
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:18477628 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions
EXP Nicotine results in increased activity of XDH protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of XDH protein]
CTD PMID:31857090 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
increases expression
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of XIAP protein; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]
Nicotine results in increased expression of XIAP mRNA; Nicotine results in increased expression of XIAP protein
CTD PMID:16601104 PMID:18676776 PMID:20727180 PMID:21267677 PMID:30259641 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978
JBrowse link
G Xist X inactive specific transcript increases expression ISO Nicotine results in increased expression of XIST mRNA CTD PMID:16949557 NCBI chr  X:72,540,753...72,558,266 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO XRCC1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase increases expression ISO Nicotine results in increased expression of YES1 mRNA CTD PMID:16949557 NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:120,646,838...120,746,441
JBrowse link
G Yipf4 Yip1 domain family, member 4 decreases expression ISO Nicotine results in decreased expression of YIPF4 mRNA CTD PMID:17997037 NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:26,682,488...26,714,066
JBrowse link
G Zc3h7a zinc finger CCCH type containing 7 A increases splicing ISO Nicotine results in increased splicing of ZC3H7A mRNA alternative form CTD PMID:23825647 NCBI chr10:4,980,147...5,019,637
Ensembl chr10:4,980,161...5,019,636
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Nicotine results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:63,787,292...63,968,960
Ensembl chr 5:63,788,217...63,968,549
JBrowse link
G Zcchc9 zinc finger CCHC-type containing 9 increases expression ISO Nicotine results in increased expression of ZCCHC9 mRNA CTD PMID:16949557 NCBI chr 2:24,773,319...24,783,339
Ensembl chr 2:24,773,319...24,781,999
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Nicotine results in increased expression of ZEB1 mRNA CTD PMID:16949557 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745
JBrowse link
G Zfp146 zinc finger protein 146 increases expression ISO Nicotine results in increased expression of ZNF146 mRNA CTD PMID:16949557 NCBI chr 1:94,537,054...94,549,315
Ensembl chr 1:94,536,083...94,551,860
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases response to substance
increases expression
increases activity
ISO [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA; [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein; Bungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
ZFP36 protein results in increased susceptibility to Nicotine
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; tin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]
Nicotine results in increased expression of ZFP36 mRNA; Nicotine results in increased expression of ZFP36 protein
Nicotine results in increased activity of ZFP36 promoter
CTD PMID:21606497 PMID:22093924 PMID:24095726 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108
JBrowse link
G Zfp42 zinc finger protein 42 increases expression
multiple interactions
ISO Nicotine results in increased expression of ZFP42 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA]
CTD PMID:15749260 NCBI chr16:55,568,903...55,577,883
Ensembl chr16:55,568,093...55,578,170
Ensembl chr 4:55,568,093...55,578,170
JBrowse link
G Zfp605 zinc finger protein 605 increases expression ISO Nicotine results in increased expression of ZNF605 mRNA CTD PMID:16949557 NCBI chr12:52,202,487...52,234,782
Ensembl chr12:52,205,132...52,234,512
JBrowse link
G Zfr zinc finger RNA binding protein multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] CTD PMID:12588870 NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:62,864,338...62,929,133
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Nicotine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:100,785,282...100,797,716
Ensembl chr 8:100,787,789...100,792,427
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 increases expression ISO Nicotine results in increased expression of ZMYND8 mRNA CTD PMID:16949557 NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:174,948,537...175,061,571
JBrowse link
G Znrf1 zinc and ring finger 1 decreases expression ISO Nicotine results in decreased expression of ZNRF1 mRNA CTD PMID:17997037 NCBI chr19:56,403,816...56,490,901
Ensembl chr19:56,405,728...56,490,881
JBrowse link
alfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Alfentanil
CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]
CTD PMID:15557344 PMID:15731592 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects metabolic processing
ISO CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 PMID:15731592 PMID:17554244 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Alfentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity
ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein
CTD PMID:7053299 PMID:11160877 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Prl prolactin increases expression
increases secretion
ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein
CTD PMID:1867878 PMID:7265421 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
JBrowse link
apocynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP acetovanillone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; acetovanillone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] CTD PMID:18474546 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased expression of ACTA2 protein] CTD PMID:29760339 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Agt angiotensinogen multiple interactions
decreases activity
ISO
EXP
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein; acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
acetovanillone inhibits the reaction [AGT protein results in decreased export of Sodium]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Oxygen]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
acetovanillone results in decreased activity of AGT protein
CTD PMID:14597645 PMID:15502880 PMID:15677497 PMID:16531806 PMID:17224469 More... NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:30366073 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B1 mRNA] CTD PMID:30651350 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein] CTD PMID:26514923 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alb albumin multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in decreased expression of ALB protein] CTD PMID:29760339 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA] CTD PMID:24080574 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] CTD PMID:22288910 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]
CTD PMID:22431579 PMID:29859868 PMID:30366073 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]
CTD PMID:22431579 PMID:29859868 PMID:30366073 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein] CTD PMID:30366073 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Becn1 beclin 1 multiple interactions EXP acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein] CTD PMID:29859868 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA] CTD PMID:24080574 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
JBrowse link
G Casp1 caspase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form] CTD PMID:26079697 PMID:26901245 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased cleavage of CASP3 mRNA]
CTD PMID:20153346 PMID:22147442 PMID:22497828 PMID:24291008 PMID:26522475 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase multiple interactions EXP [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of CAT mRNA]; acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Pyrogallol results in increased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]] CTD PMID:21983654 PMID:24291008 PMID:29760339 PMID:32298299 PMID:35944648 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:22414048 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:16845898 PMID:19158351 PMID:22414048 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
CTD PMID:10495789 PMID:22414048 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] CTD PMID:22414048 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO acetovanillone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO acetovanillone inhibits the reaction [sodium arsenite results in decreased expression of CDH1 protein] CTD PMID:39201564 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdh3 cadherin 3 multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein] CTD PMID:21647593 NCBI chr19:51,303,414...51,353,900
Ensembl chr19:51,300,083...51,354,257
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein] CTD PMID:16531806 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:16531806 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:21538410 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] CTD PMID:22414048 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 PMID:22414048 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]
CTD PMID:23270704 PMID:29037473 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [sodium arsenite results in increased expression of NOX2 protein]
CTD PMID:19878672 PMID:23270704 PMID:24080574 PMID:30797899 PMID:39201564 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of CYCS protein] CTD PMID:36988283 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
G Des desmin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347
JBrowse link
G Dmd dystrophin multiple interactions ISO acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:51,070,273...53,437,835
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP
ISO
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]; acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]
acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
CTD PMID:17391658 PMID:20977430 PMID:22431579 PMID:24932781 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:23270704 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein] CTD PMID:26514923 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:23270704 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions ISO acetovanillone inhibits the reaction [arsenite results in increased expression of ERO1A protein] CTD PMID:37659621 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP acetovanillone inhibits the reaction [Gentamicins results in increased expression of FAS protein] CTD PMID:28116922 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]
acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]
CTD PMID:15086456 PMID:16632126 PMID:22245600 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of FSHB protein] CTD PMID:23270704 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein] CTD PMID:18063801 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein] CTD PMID:23270704 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:25042521 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191
JBrowse link
G Gna11 G protein subunit alpha 11 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of GNA11 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNA11 protein] CTD PMID:20691780 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,814,327...8,830,558
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of GNAQ protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein] CTD PMID:20691780 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]; acetovanillone inhibits the reaction [Pyrogallol results in increased activity of GPX1 protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:22431579 PMID:29037473 PMID:35944648 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP acetovanillone inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA] CTD PMID:21983654 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein] CTD PMID:30797899 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein] CTD PMID:30378427 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 increases expression EXP acetovanillone results in increased expression of GUCY1A1 protein CTD PMID:25217652 NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 increases expression EXP acetovanillone results in increased expression of GUCY1B1 protein CTD PMID:25217652 NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987
JBrowse link
G Gypa glycophorin A multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr19:44,354,669...44,370,304
Ensembl chr19:44,354,706...44,370,291
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP
ISO
acetovanillone results in increased expression of HIF1A protein
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:12595275 PMID:23144690 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] CTD PMID:26079697 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [mevastatin results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
acetovanillone results in decreased expression of HMOX1 mRNA
CTD PMID:19414066 PMID:20934533 PMID:21690482 PMID:24291008 PMID:26945724 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:117,114,633...117,117,793
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
acetovanillone results in decreased expression of ICAM1 protein
CTD PMID:10495789 PMID:19417757 PMID:19632255 PMID:20920494 PMID:22414048 More... NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
acetovanillone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]
CTD PMID:16307444 PMID:30366073 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il18 interleukin 18 multiple interactions ISO acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] CTD PMID:28539244 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO
EXP
acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA]; acetovanillone inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
acetovanillone inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]
acetovanillone results in decreased susceptibility to IL1B protein
acetovanillone inhibits the reaction [Ethanol results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
CTD PMID:18403674 PMID:19005069 PMID:19281832 PMID:21211511 PMID:21983654 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Pyrogallol results in increased expression of IL6 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:21983654 PMID:22414048 PMID:22472292 PMID:24631921 PMID:25042521 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:29760339 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]
CTD PMID:16357311 PMID:28202386 PMID:30797899 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of JUN mRNA]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of JUN protein] CTD PMID:22288910 PMID:36988283 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Lep leptin multiple interactions ISO acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]; acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein] CTD PMID:16380530 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lepr leptin receptor multiple interactions ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of LHB protein] CTD PMID:23270704 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lpo lactoperoxidase multiple interactions EXP acetovanillone inhibits the reaction [Pyrogallol results in increased activity of LPO protein] CTD PMID:35944648 NCBI chr10:73,104,170...73,124,683
Ensembl chr10:73,104,188...73,123,456
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased lipidation of MAP1LC3B protein] CTD PMID:29859868 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:16632126 PMID:20354174 PMID:21391979 PMID:22288910 PMID:23774252 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:16632126 PMID:20354174 PMID:21391979 PMID:22288910 PMID:23774252 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of MAPK8 mRNA]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of MAPK8 protein]
CTD PMID:20354174 PMID:21391979 PMID:24967690 PMID:26514923 PMID:36988283 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:21391979 PMID:24967690 PMID:26514923 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] CTD PMID:22414048 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MLKL protein] CTD PMID:30378427 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]; acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]
CTD PMID:23270704 PMID:23774252 PMID:26514923 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase decreases expression
multiple interactions
ISO
EXP
acetovanillone results in decreased expression of MPO protein
acetovanillone inhibits the reaction [Cisplatin results in increased activity of MPO protein]
CTD PMID:19417757 PMID:24291008 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:59,421,250...59,507,070
Ensembl chr16:59,421,057...59,507,070
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]
acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [Arsenic Trioxide affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [mevastatin results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [N-Methylaspartate affects the localization of NCF1 protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF1 mRNA]
CTD PMID:16380530 PMID:18424721 PMID:19281832 PMID:19878672 PMID:20299304 More... NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]
CTD PMID:16380530 PMID:24080574 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO acetovanillone inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein] CTD PMID:22564430 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:24291008 PMID:27983965 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; acetovanillone inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]
CTD PMID:16845898 PMID:17065336 PMID:28202386 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]
acetovanillone inhibits the reaction [sodium arsenite results in increased expression of NLRP3 protein]
CTD PMID:26901245 PMID:39201564 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
CTD PMID:21983654 PMID:26522475 PMID:28202386 PMID:30797899 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
ISO
EXP
acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein]
[Cadmium co-treated with acetovanillone] results in increased expression of NOS3 protein; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS3 mRNA]
acetovanillone results in increased expression of NOS3 protein
CTD PMID:19878672 PMID:21983654 PMID:23703608 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]
CTD PMID:26522475 PMID:29760339 PMID:30797899 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP
ISO
[acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX4 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of NOX4 protein]
CTD PMID:26522475 PMID:29760339 PMID:32298299 PMID:36988283 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
JBrowse link
G Noxa1 NADPH oxidase activator 1 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXA1 mRNA] CTD PMID:24080574 NCBI chr 3:28,293,643...28,309,828
Ensembl chr 3:28,293,658...28,304,022
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXO1 mRNA] CTD PMID:24080574 NCBI chr10:14,226,473...14,230,541
Ensembl chr10:14,228,205...14,230,541
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:70,993,622...71,011,585
Ensembl chr13:70,999,186...71,011,572
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA] CTD PMID:19878672 NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]
acetovanillone inhibits the reaction [arsenite results in increased oxidation of PARP1 protein]; acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]
CTD PMID:15502880 PMID:18509044 PMID:24932781 PMID:29111459 PMID:34798142 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP acetovanillone inhibits the reaction [Ozone results in increased expression of PCNA protein] CTD PMID:9517619 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB1 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein] CTD PMID:20691780 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB2 protein] CTD PMID:20691780 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP acetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes] CTD PMID:16053986 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of PRKCD protein]
CTD PMID:29859868 PMID:30366073 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP acetovanillone inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein] CTD PMID:18414395 PMID:21983654 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP
ISO
acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Pyrogallol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]
acetovanillone results in decreased expression of PTGS2 mRNA
CTD PMID:17244722 PMID:18414395 PMID:21983654 PMID:22288910 PMID:23415682 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806
JBrowse link
G Pvalb parvalbumin multiple interactions ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] CTD PMID:18063801 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of PYCARD protein] CTD PMID:26079697 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]
acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]
CTD PMID:19281832 PMID:19608869 PMID:20354174 PMID:23774252 PMID:26930420 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of RUNX2 mRNA] CTD PMID:24080574 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein] CTD PMID:21647593 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837
JBrowse link
G Sele selectin E multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SELE protein] CTD PMID:26901245 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:22414048 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 protein] CTD PMID:23270704 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460
JBrowse link
G Snca synuclein alpha multiple interactions EXP acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased phosphorylation of SNCA protein] CTD PMID:29859868 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:21983654 PMID:22431579 PMID:29037473 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]
CTD PMID:21983654 PMID:22431579 PMID:29037473 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP acetovanillone inhibits the reaction [Hydrogen Peroxide deficiency results in decreased expression of STAR protein]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein] CTD PMID:23270704 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD PMID:18322232 PMID:29859868 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased expression of TGFB1 protein] CTD PMID:29760339 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Th tyrosine hydroxylase decreases expression
multiple interactions
EXP acetovanillone results in decreased expression of TH mRNA
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]
CTD PMID:25217652 PMID:29859868 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]
acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
CTD PMID:20299304 PMID:21647593 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO
EXP
acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]; acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
acetovanillone results in decreased susceptibility to TNF protein
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:10495789 PMID:15795323 PMID:16632126 PMID:19608869 PMID:21211511 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein] CTD PMID:22431579 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions EXP Apocynin inhibits the reaction [hydrogen peroxide increases expression of Traf6 protein in rat neonatal cardiomyocytes] RGD PMID:27249171 RGD:155646134 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of VCAM1 protein] CTD PMID:19281832 PMID:19632255 PMID:26901245 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP
ISO
acetovanillone inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein] CTD PMID:39201564 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin multiple interactions ISO acetovanillone inhibits the reaction [sodium arsenite results in decreased expression of VIM protein] CTD PMID:39201564 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP acetovanillone inhibits the reaction [Cocaine results in increased activity of XDH protein] CTD PMID:17217956 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
JBrowse link
aprepitant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO Arsenic Trioxide promotes the reaction [Aprepitant results in increased expression of BAD mRNA] CTD PMID:30145367 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Arsenic Trioxide promotes the reaction [Aprepitant results in increased expression of BAX mRNA] CTD PMID:30145367 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of BCL2 mRNA CTD PMID:30145367 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in increased expression of BID mRNA CTD PMID:30145367 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Aprepitant results in decreased expression of BIRC2 mRNA
Arsenic Trioxide promotes the reaction [Aprepitant results in decreased expression of BIRC2 mRNA]
CTD PMID:30145367 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression
ISO Arsenic Trioxide promotes the reaction [Aprepitant results in decreased expression of BIRC3 mRNA] CTD PMID:30145367 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of BIRC5 mRNA CTD PMID:30145367 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Aprepitant results in increased activity of CASP3 protein
Aprepitant promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Arsenic Trioxide promotes the reaction [Aprepitant results in increased activity of CASP3 protein]
CTD PMID:30145367 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in increased expression of CDKN1A mRNA CTD PMID:30145367 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased expression of KLF4 protein]]; Aprepitant inhibits the reaction [Rotenone results in decreased expression of KLF4 protein] CTD PMID:37224993 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased phosphorylation of MAPK7 protein]]; Aprepitant inhibits the reaction [Rotenone results in decreased phosphorylation of MAPK7 protein] CTD PMID:37224993 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of MCL1 mRNA CTD PMID:30145367 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO aprepitant inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA] CTD PMID:18441096 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of MYC mRNA CTD PMID:30145367 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased expression of NFE2L2 protein]]; Aprepitant inhibits the reaction [Rotenone results in decreased expression of NFE2L2 protein] CTD PMID:37224993 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO Aprepitant results in decreased phosphorylation of NFKBIA protein
Arsenic Trioxide promotes the reaction [Aprepitant results in decreased phosphorylation of NFKBIA protein]
CTD PMID:30145367 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Pgr progesterone receptor multiple interactions ISO aprepitant binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
JBrowse link
G Snca synuclein alpha multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]]; Aprepitant inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein] CTD PMID:37224993 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein]]; Aprepitant inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein] CTD PMID:37224993 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO aprepitant inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA]; aprepitant inhibits the reaction [TAC1 protein results in increased expression of TACR1 mRNA] CTD PMID:18441096 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO aprepitant binds to and results in decreased activity of TACR1 protein
aprepitant inhibits the reaction [TAC1 protein results in increased expression of TACR1 mRNA]
CTD PMID:18441096 PMID:20623144 PMID:20718754 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Aprepitant inhibits the reaction [Rotenone results in decreased expression of TH protein]]; Aprepitant inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:37224993 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO aprepitant binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in increased expression of TP73 mRNA CTD PMID:30145367 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of XIAP mRNA CTD PMID:30145367 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978
JBrowse link
chloroprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO chloroprocaine results in increased expression of BAX protein
LINC00494 inhibits the reaction [chloroprocaine results in increased expression of BAX protein]
CTD PMID:37650745 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO chloroprocaine results in decreased expression of CCND1 protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of CCND1 protein]
CTD PMID:37650745 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Med19 mediator complex subunit 19 decreases expression
multiple interactions
ISO chloroprocaine results in decreased expression of MED19 mRNA; chloroprocaine results in decreased expression of MED19 protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of MED19 mRNA]; LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of MED19 protein]
CTD PMID:37650745 NCBI chr 3:90,168,829...90,179,351
Ensembl chr 3:90,168,829...90,179,351
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
ISO chloroprocaine results in decreased expression of PCNA protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of PCNA protein]
CTD PMID:37650745 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
JBrowse link
ecgonine methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase multiple interactions
increases chemical synthesis
increases abundance
ISO [BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of ecgonine methyl ester
BCHE protein mutant form results in increased chemical synthesis of ecgonine methyl ester
BCHE protein mutant form results in increased abundance of ecgonine methyl ester
CTD PMID:25814464 PMID:30080993 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Dipyrone analog results in decreased activity of PTGS1 protein; Dipyrone results in decreased activity of PTGS1 protein CTD PMID:12242329 PMID:16141368 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase decreases expression
increases methylation
EXP Nicotine results in decreased expression of AACS mRNA
Nicotine results in increased methylation of AACS promoter
CTD PMID:26776438 NCBI chr12:36,774,471...36,817,835
Ensembl chr12:36,774,471...36,822,543
JBrowse link
G Aatk apoptosis-associated tyrosine kinase increases expression ISO Nicotine results in increased expression of AATK mRNA CTD PMID:18247414 NCBI chr10:105,789,171...105,825,634
Ensembl chr10:105,785,469...105,825,618
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 protein
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]
CTD PMID:30036686 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of ABCG1 mRNA; Nicotine results in decreased expression of ABCG1 protein
Nicotine results in increased expression of ABCG1 protein
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]
CTD PMID:30036686 PMID:31629012 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Nicotine results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 increases expression ISO Nicotine results in increased expression of ABTB3 mRNA CTD PMID:21955143 PMID:23825647 NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA] CTD PMID:20230807 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Nicotine results in increased expression of ACACA mRNA CTD PMID:24368177 PMID:29155039 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Acan aggrecan decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of ACAN mRNA; Nicotine results in decreased expression of ACAN protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779
JBrowse link
G Ace angiotensin I converting enzyme increases expression ISO Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942
JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of ACHE protein
Nicotine results in increased activity of ACHE protein
Nicotine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
CTD PMID:20097188 PMID:21633116 PMID:23033686 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Nicotine results in decreased expression of ACOT13 mRNA CTD PMID:17997037 NCBI chr17:40,668,404...40,680,876
Ensembl chr17:40,668,316...40,680,876
JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Nicotine results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:53,233,948...53,251,959
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases splicing ISO Nicotine results in increased splicing of ACSL1 mRNA alternative form CTD PMID:23825647 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions
increases expression
ISO
EXP
Mecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]
Nicotine results in increased expression of ACSL6 mRNA
CTD PMID:22205969 NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,940,747...39,002,873
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of ACTA1 mRNA
Nicotine results in decreased expression of ACTA1 mRNA
CTD PMID:17997037 PMID:27782041 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Quartz results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Arginine results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 mRNA; Nicotine results in increased expression of ACTA2 protein
CTD PMID:33640489 PMID:34153408 PMID:36720419 PMID:36868510 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Actb actin, beta increases expression ISO Nicotine results in increased expression of ACTB mRNA CTD PMID:17997037 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:255,179,242...255,199,459
JBrowse link
G Actrt2 actin-related protein T2 decreases expression EXP Nicotine results in decreased expression of ACTRT2 mRNA CTD PMID:27782041 NCBI chr 5:170,518,470...170,519,870
Ensembl chr 5:170,518,165...170,521,164
JBrowse link
G Ada adenosine deaminase increases activity
multiple interactions
EXP Nicotine results in increased activity of ADA protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein]
CTD PMID:31857090 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Nicotine results in increased expression of ADAM19 mRNA CTD PMID:23825647 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:34,913,154...34,972,366
Ensembl chr19:34,914,322...34,936,743
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Nicotine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:204,059,218...204,102,869
Ensembl chr 1:204,059,367...204,102,869
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO Nicotine results in increased expression of ADGRG1 mRNA CTD PMID:23825647 NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:41,107,162...41,148,752
Ensembl chr19:41,109,117...41,148,896
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Nicotine results in increased expression of ADIPOR2 mRNA CTD PMID:22265867 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666
JBrowse link
G Adk adenosine kinase increases expression ISO Nicotine results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,912,544...3,295,745
JBrowse link
G Adm2 adrenomedullin 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of ADM2 protein CTD PMID:19910445 NCBI chr 7:122,272,808...122,274,594
Ensembl chr 7:122,272,808...122,274,594
JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA] CTD PMID:20230807 NCBI chr 3:177,310,258...177,340,379
Ensembl chr 3:177,310,258...177,336,188
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Nicotine results in decreased expression of ADORA2A mRNA CTD PMID:21955143 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
increases expression
ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB1 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB2 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein increases expression ISO Nicotine results in increased expression of ADTRP mRNA CTD PMID:23825647 NCBI chr17:23,113,578...23,199,616
Ensembl chr17:23,135,809...23,216,622
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Nicotine results in increased expression of AGTR1B mRNA CTD PMID:22728133 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression
affects expression
EXP Nicotine results in decreased expression of AGTR2 mRNA; Nicotine results in decreased expression of AGTR2 protein
Nicotine affects the expression of AGTR2 protein
CTD PMID:19429393 PMID:22691361 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Nicotine results in increased expression of AHR mRNA CTD PMID:34171359 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor decreases expression EXP Nicotine results in decreased expression of AHRR protein CTD PMID:35577041 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866
JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Nicotine results in increased expression of AK3 mRNA CTD PMID:17456735 NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183
JBrowse link
G Ak5 adenylate kinase 5 increases expression ISO Nicotine results in increased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:244,057,240...244,241,372
Ensembl chr 2:244,057,240...244,241,366
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of AKR1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases expression
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein
IGF1 protein inhibits the reaction [Nicotine results in decreased phosphorylation of AKT1 protein]
Nicotine results in increased expression of AKT1 mRNA
CTD PMID:12511591 PMID:15983034 PMID:20727180 PMID:24095863 PMID:30836163 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression
increases expression
EXP
ISO
Nicotine affects the expression of AKT2 mRNA
Nicotine results in increased expression of AKT2 mRNA
CTD PMID:31945395 PMID:31972234 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO Nicotine results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041
JBrowse link
G Alb albumin increases expression
decreases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of ALB protein
Nicotine results in decreased expression of ALB protein
dexpanthenol inhibits the reaction [Nicotine results in decreased expression of ALB protein]
CTD PMID:25662863 PMID:36720419 PMID:38229321 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity
multiple interactions
ISO Nicotine results in increased activity of ALDH1A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]
CTD PMID:20230807 PMID:23219715 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Nicotine results in increased expression of ALOX12 mRNA CTD PMID:16254210 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]
Nicotine results in increased expression of ALOX5 mRNA; Nicotine results in increased expression of ALOX5 protein
CTD PMID:14569062 PMID:20061081 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Nicotine results in decreased expression of ALPL mRNA CTD PMID:39207236 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO Nicotine results in increased expression of AMD1 mRNA CTD PMID:16949557 NCBI chr20:45,250,289...45,324,939
Ensembl chr20:45,250,289...45,265,982
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 decreases expression ISO Nicotine results in decreased expression of AMHR2 mRNA CTD PMID:18247414 NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:135,457,922...135,471,104
JBrowse link
G Angpt4 angiopoietin 4 increases expression ISO Nicotine results in increased expression of ANGPT4 mRNA CTD PMID:23825647 NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:160,880,728...160,913,921
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Nicotine results in decreased expression of ANGPTL4 mRNA CTD PMID:32512034 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681
JBrowse link
G Ano3 anoctamin 3 decreases expression ISO Nicotine results in decreased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:117,690,242...118,004,695
Ensembl chr 3:117,692,103...118,004,675
JBrowse link
G Anxa1 annexin A1 decreases expression
increases expression
EXP Nicotine results in decreased expression of ANXA1 mRNA
Nicotine results in increased expression of ANXA1 protein
CTD PMID:26776438 PMID:39824327 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase decreases expression ISO Nicotine results in decreased expression of APEH mRNA CTD PMID:16949557 NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:117,652,393...117,661,711
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
JBrowse link
G Api5 apoptosis inhibitor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of API5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of API5 mRNA] CTD PMID:20230807 NCBI chr 3:100,833,417...100,858,580
Ensembl chr 3:100,833,417...100,858,580
JBrowse link
G Apoe apolipoprotein E increases expression ISO Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
decreases expression
ISO
EXP
[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]
Nicotine results in decreased expression of APP protein alternative form
Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP protein
CTD PMID:16474004 PMID:16627626 PMID:17135361 PMID:29618714 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Nicotine results in increased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO Nicotine results in increased expression of ARC mRNA CTD PMID:23825647 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220
JBrowse link
G Arf1 ARF GTPase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:44,497,543...44,513,994 JBrowse link
G Arf3 ARF GTPase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF3 mRNA] CTD PMID:20230807 NCBI chr 7:131,765,039...131,792,075
Ensembl chr 7:131,750,672...131,770,123
JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Nicotine results in increased expression of ARGLU1 mRNA CTD PMID:16949557 NCBI chr16:87,455,097...87,479,148
Ensembl chr16:87,455,113...87,479,148
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA CTD PMID:28065790 NCBI chr 2:148,889,405...149,000,538
Ensembl chr 2:148,889,423...149,000,538
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 decreases expression ISO Nicotine results in decreased expression of ARHGEF7 mRNA CTD PMID:12588870 NCBI chr16:84,373,123...84,484,759
Ensembl chr16:84,373,123...84,484,597
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression ISO Nicotine results in decreased expression of ARID1A mRNA CTD PMID:17997037 NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:151,192,014...151,265,386
JBrowse link
G Arl15 ARF like GTPase 15 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA CTD PMID:28065790 NCBI chr 2:47,171,377...47,555,666
Ensembl chr 2:47,094,900...47,555,666
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression EXP Nicotine results in decreased expression of ARNT protein CTD PMID:35577041 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 decreases expression ISO Nicotine results in decreased expression of ARPP21 mRNA CTD PMID:21955143 NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:120,912,970...121,031,357
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:16862215 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859
JBrowse link
G Arvcf ARVCF, delta catenin family member decreases response to substance ISO ARVCF gene mutant form results in decreased susceptibility to Nicotine CTD PMID:38025780 NCBI chr11:96,092,451...96,150,144
Ensembl chr11:96,092,451...96,150,163
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP Nicotine results in decreased expression of ASCL1 mRNA CTD PMID:28555334 NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:23,790,360...23,798,231
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression EXP Nicotine results in decreased expression of ASCL2 mRNA CTD PMID:24368670 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856
JBrowse link
G Aspm assembly factor for spindle microtubules multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA] CTD PMID:20230807 NCBI chr13:53,625,584...53,674,489
Ensembl chr13:53,625,584...53,674,489
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Nicotine results in increased expression of ATF3 mRNA CTD PMID:17456735 PMID:24927667 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein] CTD PMID:18477628 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions
increases expression
ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 4:95,241,933...95,244,028
Ensembl chr 4:95,241,933...95,244,019
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nicotine results in decreased expression of ATP5F1A protein CTD PMID:28681937 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases splicing ISO Nicotine results in increased splicing of ATP5F1E mRNA alternative form CTD PMID:23825647 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP6V0A4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0A4 mRNA] CTD PMID:20230807 NCBI chr 4:67,727,145...67,809,092
Ensembl chr 4:67,727,145...67,809,092
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA] CTD PMID:20230807 NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:177,779,203...178,023,661
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718
JBrowse link
G Atrn attractin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:138,563,271...138,697,360
Ensembl chr 3:138,563,312...138,697,360
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression
decreases expression
ISO Nicotine results in increased expression of ATRX mRNA
Nicotine results in decreased expression of ATRX mRNA
CTD PMID:16949557 PMID:21955143 NCBI chr  X:74,916,548...75,062,880
Ensembl chr  X:74,916,548...75,062,880
JBrowse link
G Avp arginine vasopressin decreases expression
increases secretion
ISO
EXP
Nicotine results in decreased expression of AVP mRNA
Nicotine results in increased secretion of AVP protein alternative form
CTD PMID:3681699 PMID:17456735 PMID:28555334 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
JBrowse link
G Axin1 axin 1 multiple interactions ISO [Nicotine co-treated with nuciferine] results in increased expression of AXIN1 protein CTD PMID:25698245 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092
JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Nicotine results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:136,697,981...136,707,783
Ensembl chr 5:136,697,981...136,710,422
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
decreases phosphorylation
ISO
EXP
Nicotine results in decreased expression of BAD mRNA
Nicotine results in decreased phosphorylation of BAD protein
CTD PMID:18247414 PMID:20447445 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
JBrowse link
G Bap1 BRCA1 associated deubiquitinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA] CTD PMID:20230807 NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,452,974...6,461,952
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases phosphorylation
decreases expression
increases expression
multiple interactions
affects localization
ISO
EXP
Nicotine results in increased phosphorylation of BAX protein
Nicotine results in decreased expression of BAX protein
Nicotine results in increased expression of BAX protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of BAX protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]; IGF1 protein inhibits the reaction [Nicotine results in increased expression of BAX protein]
Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein
Nicotine affects the localization of BAX protein
Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein
3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; nuciferine inhibits the reaction [Nicotine results in decreased expression of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
CTD PMID:15831280 PMID:17135361 PMID:17525161 PMID:18203686 PMID:18676776 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Nicotine results in increased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:179,554,754...179,637,800
Ensembl chr 3:179,551,704...179,637,743
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression ISO Nicotine results in increased expression of BCL11B mRNA CTD PMID:21955143 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:132,598,968...132,691,301
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
increases phosphorylation
ISO
EXP
3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]; nuciferine inhibits the reaction [Nicotine results in increased expression of BCL2 protein]
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]
Nicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 protein
Nicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified form
CTD PMID:12421819 PMID:15831280 PMID:18448488 PMID:18676776 PMID:20061081 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Nicotine results in decreased expression of BCL2A1 mRNA CTD PMID:18247414 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of BCL2L1 mRNA
Nicotine results in decreased expression of BCL2L1 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of BCL2L1 mRNA]
CTD PMID:22687363 PMID:38229321 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bcl2l10 Bcl2-like 10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2L10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2L10 mRNA] CTD PMID:20230807 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:84,987,833...84,993,872
JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
multiple interactions
increases expression
affects expression
increases secretion
ISO
EXP
BDNF gene polymorphism affects the susceptibility to Nicotine
nicotine increases expression of Bdnf protein in striatum
[Nicotine co-treated with Quartz] results in increased expression of BDNF protein
Nicotine results in increased expression of BDNF mRNA
Nicotine affects the expression of BDNF mRNA
Nicotine results in increased secretion of BDNF protein
methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein]
CTD
RGD
PMID:9503263 PMID:9832142 PMID:16790237 PMID:17186223 PMID:20426880 More... RGD:598154614 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of BECN1 mRNA
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
CTD PMID:30605750 PMID:31926917 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of BGLAP
Nicotine results in decreased expression of BGLAP mRNA; Nicotine results in decreased expression of BGLAP protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
CTD PMID:19436947 PMID:29981921 PMID:39207236 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]
CTD PMID:20727180 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]
Nicotine results in increased expression of BIRC5 mRNA; Nicotine results in increased expression of BIRC5 protein
CTD PMID:16601104 PMID:19896492 PMID:20727180 PMID:21267677 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
multiple interactions
ISO Nicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 protein
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]
CTD PMID:23219715 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nicotine results in decreased expression of BMP4 mRNA CTD PMID:20339300 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA CTD PMID:33091441 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Nicotine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Nicotine results in decreased expression of BRAF mRNA; Nicotine results in decreased expression of BRAF protein CTD PMID:17135361 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO Nicotine results in decreased expression of BRCA1 mRNA
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]
CTD PMID:18247414 PMID:23907605 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763
JBrowse link
G Brd2 bromodomain containing 2 increases expression ISO Nicotine results in increased expression of BRD2 mRNA CTD PMID:33640489 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of BST2 mRNA CTD PMID:37951547 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO Nicotine results in decreased expression of BTF3 mRNA CTD PMID:18247414 NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Nicotine results in increased expression of BTG2 mRNA CTD PMID:17456735 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690
JBrowse link
G Btk Bruton tyrosine kinase decreases expression ISO Nicotine results in decreased expression of BTK mRNA CTD PMID:18247414 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:102,016,074...102,055,143
JBrowse link
G C1r complement C1r multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:159,098,918...159,109,714
JBrowse link
G C1s complement C1s multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736
JBrowse link
G C3ar1 complement C3a receptor 1 increases expression ISO Nicotine results in increased expression of C3AR1 mRNA CTD PMID:23825647 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO Nicotine results in decreased expression of C5AR1 mRNA CTD PMID:18247414 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C7 complement C7 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] CTD PMID:16949557 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Nicotine results in decreased expression of CAR3 mRNA CTD PMID:27782041 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression ISO Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F increases expression ISO Nicotine results in increased expression of CACNA1F mRNA CTD PMID:11756415 NCBI chr  X:17,539,992...17,568,308
Ensembl chr  X:17,539,920...17,568,308
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP Nicotine results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Nicotine results in increased expression of CACNA2D1 protein CTD PMID:11756415 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP Nicotine results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:93,152,558...93,165,246
Ensembl chr10:93,152,248...93,165,417
JBrowse link
G Cadm3 cell adhesion molecule 3 increases expression EXP Nicotine results in increased expression of CADM3 mRNA CTD PMID:27782041 NCBI chr13:88,317,124...88,349,718
Ensembl chr13:88,317,124...88,350,114
JBrowse link
G Calb1 calbindin 1 increases expression
multiple interactions
EXP Nicotine results in increased expression of CALB1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of CALB1 protein]
CTD PMID:11226671 NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of CALCRL protein CTD PMID:19910445 NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CALM1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381
JBrowse link
G Calr calreticulin increases expression ISO Nicotine results in increased expression of CALR mRNA CTD PMID:16949557 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO Nicotine results in increased expression of CAMK2A mRNA CTD PMID:21955143 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Nicotine results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Nicotine results in increased expression of CAMP mRNA CTD PMID:23825647 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:118,720,184...118,721,998
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Nicotine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:140,427,269...140,453,470
JBrowse link
G Capn10 calpain 10 increases expression ISO Nicotine results in increased expression of CAPN10 mRNA CTD PMID:17997037 NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:100,945,551...100,957,912
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 increases expression ISO Nicotine results in increased expression of CAPZA2 mRNA CTD PMID:16949557 NCBI chr 4:46,944,040...46,979,930
Ensembl chr 4:46,895,701...46,979,938
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP
ISO
Nicotine results in decreased expression of CARTPT protein
Nicotine results in decreased expression of CARTPT mRNA
CTD PMID:18247414 PMID:23623838 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO
EXP
CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein]; Nicotine results in increased expression of and results in increased cleavage of CASP1 protein
Nicotine results in increased expression of CASP1 mRNA
Nicotine results in increased expression of CASP1 protein
CTD PMID:16927020 PMID:35131329 PMID:39098741 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP12 mRNA]
Nicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]
CTD PMID:18477628 PMID:20230807 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
JBrowse link
G Casp14 caspase 14 increases expression ISO Nicotine results in increased expression of CASP14 mRNA CTD PMID:23825647 NCBI chr 7:11,577,315...11,583,987
Ensembl chr 7:11,580,339...11,583,171
JBrowse link
G Casp2 caspase 2 affects expression EXP Nicotine affects the expression of CASP2 mRNA CTD PMID:20426880 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
affects expression
decreases expression
decreases activity
ISO
EXP
geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Nicotine results in increased cleavage of CASP3 protein
Nicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative form
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein
Nicotine affects the expression of CASP3 mRNA
[Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
Nicotine results in decreased activity of CASP3 protein
CTD PMID:11701223 PMID:12115584 PMID:12218695 PMID:15831280 PMID:16237857 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 affects expression EXP Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
dexpanthenol inhibits the reaction [Nicotine results in increased expression of CASP9 protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein]
Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]
Nicotine results in decreased expression of CASP9 mRNA
CTD PMID:16949557 PMID:18676776 PMID:20230807 PMID:29972271 PMID:38229321 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP
ISO
[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
Nicotine results in increased activity of CAT protein
CTD PMID:10509436 PMID:10874619 PMID:10906423 PMID:11747978 PMID:15925865 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cav2 caveolin 2 decreases expression ISO Nicotine results in decreased expression of CAV2 mRNA CTD PMID:33640489 NCBI chr 4:46,582,681...46,590,058
Ensembl chr 4:46,582,096...46,591,425
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO Nicotine results in increased expression of CBL mRNA CTD PMID:18247414 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067
JBrowse link
G Cbln1 cerebellin 1 precursor increases expression ISO Nicotine results in increased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:35,782,151...35,785,960
Ensembl chr19:35,781,952...35,785,960
JBrowse link
G Cbx3 chromobox 3 increases expression ISO Nicotine results in increased expression of CBX3 mRNA CTD PMID:16949557 NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:81,876,649...81,889,911
JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:136,211,649...136,229,118
JBrowse link
G Ccdc136 coiled-coil domain containing 136 increases expression ISO Nicotine results in increased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:58,963,196...58,992,962
Ensembl chr 4:58,962,908...58,992,975
JBrowse link
G Ccdc159 coiled-coil domain containing 159 increases expression ISO Nicotine results in increased expression of CCDC159 mRNA CTD PMID:23825647 NCBI chr 8:28,733,988...28,742,646
Ensembl chr 8:28,725,003...28,744,890
JBrowse link
G Ccdc167 coiled-coil domain containing 167 increases expression ISO Nicotine results in increased expression of CCDC167 mRNA CTD PMID:23825647 NCBI chr20:7,768,425...7,783,181
Ensembl chr20:7,753,072...7,783,181
JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO Nicotine results in increased expression of CCDC88A mRNA CTD PMID:17456735 NCBI chr14:107,304,654...107,456,104
Ensembl chr14:107,305,199...107,453,285
JBrowse link
G Cck cholecystokinin decreases expression ISO Nicotine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein
Nicotine results in decreased secretion of CCL2 protein
Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
CTD PMID:15135227 PMID:15976189 PMID:22093924 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Nicotine results in increased expression of CCL5 mRNA CTD PMID:18247414 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Nicotine results in increased expression of CCN1 mRNA CTD PMID:17456735 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Nicotine results in increased expression of CCN2 protein CTD PMID:22691361 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Nicotine results in increased expression of CCN5 mRNA CTD PMID:23825647 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:172,910,681...172,922,062
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Nicotine results in increased expression of CCNA2 protein CTD PMID:18448488 PMID:20106947 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CCNB1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA]
CTD PMID:20106947 PMID:20230807 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases activity
ISO
EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]
Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein
Nicotine results in increased activity of CCND1 promoter
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]
Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein
CTD PMID:15574422 PMID:15983034 PMID:17135361 PMID:18448488 PMID:18805435 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]
Nicotine results in decreased expression of CCND2 protein
CTD PMID:15231866 PMID:20230807 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Nicotine results in increased expression of CCNG2 mRNA CTD PMID:23416264 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206
JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:171,699,689...171,711,231
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Nicotine results in decreased expression of CCR6 mRNA CTD PMID:18247414 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Nicotine results in increased expression of CCS protein CTD PMID:16627626 NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260
JBrowse link
G Cd151 CD151 molecule (Raph blood group) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD151 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CD151 mRNA] CTD PMID:20230807 NCBI chr 1:205,994,300...205,998,307
Ensembl chr 1:205,994,738...205,998,784
JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Nicotine results in decreased expression of CD4 mRNA CTD PMID:18247414 NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA] CTD PMID:20230807 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424
JBrowse link
G Cd46 CD46 molecule increases expression ISO Nicotine results in increased expression of CD46 mRNA CTD PMID:16949557 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Cd59b CD59b molecule increases expression ISO Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:110,914,091...110,935,310
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540
JBrowse link
G Cd86 CD86 molecule increases expression EXP Nicotine results in increased expression of CD86 mRNA CTD PMID:27782041 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361
JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA] CTD PMID:20230807 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] CTD PMID:16862215 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA] CTD PMID:20230807 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]
[Nicotine co-treated with Quartz] results in increased expression of CDH1 protein
Nicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 protein
CTD PMID:18844224 PMID:20061081 PMID:23219715 PMID:36868510 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO [Nicotine co-treated with Quartz] results in increased expression of CDH2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of CDH2 protein] CTD PMID:36868510 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CDK1 protein
CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]
CTD PMID:35929799 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO Nicotine results in increased expression of CDK13 mRNA CTD PMID:16949557 NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] CTD PMID:35929799 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
Nicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 protein
CTD PMID:15231866 PMID:17135361 PMID:18805435 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]
Nicotine results in increased expression of CDK6 mRNA
CTD PMID:16949557 PMID:18805435 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]
Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]
CTD PMID:16011614 PMID:16601104 PMID:18805435 PMID:20727180 PMID:30272249 More... NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Nicotine results in decreased expression of CDKN1B protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]; Nicotine results in increased expression of and results in increased stability of CDKN1B protein
CTD PMID:15231866 PMID:18805435 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]
Nicotine results in increased expression of CDKN2A mRNA; Nicotine results in increased expression of CDKN2A protein
CTD PMID:32473187 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases splicing ISO Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 NCBI chr14:8,126,678...8,187,243
Ensembl chr14:8,124,838...8,187,218
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
affects expression
increases expression
EXP
ISO
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein
Nicotine affects the expression of CEBPA mRNA
Nicotine results in increased expression of CEBPA mRNA
CTD PMID:29617909 PMID:31622651 PMID:31972234 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CEBPB mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA
CTD PMID:18805435 PMID:29617909 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression EXP Nicotine results in increased expression of CELF6 mRNA CTD PMID:27782041 NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:68,871,093...68,901,863
JBrowse link
G Cenpe centromere protein E increases expression ISO Nicotine results in increased expression of CENPE mRNA CTD PMID:16949557 NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:226,300,798...226,369,636
JBrowse link
G Cers6 ceramide synthase 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA CTD PMID:28065790 NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544
JBrowse link
G Cetn2 centrin 2 decreases expression ISO Nicotine results in decreased expression of CETN2 mRNA CTD PMID:17997037 NCBI chr  X:155,812,212...155,817,186
Ensembl chr  X:155,812,003...155,817,744
JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:13,817,760...13,837,502
Ensembl chr 2:13,824,803...13,837,502
JBrowse link
G Cfap43 cilia and flagella associated protein 43 decreases expression ISO Nicotine results in decreased expression of CFAP43 mRNA CTD PMID:23825647 NCBI chr 1:256,566,558...256,653,816
Ensembl chr 1:256,566,559...256,653,840
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression ISO Nicotine results in increased expression of CGA mRNA CTD PMID:23825647 NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:54,235,019...54,295,464
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression ISO Nicotine results in increased expression of CGREF1 mRNA CTD PMID:23825647 NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:31,151,795...31,163,800
JBrowse link
G Chat choline O-acetyltransferase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of CHAT protein
Nicotine results in increased activity of CHAT protein
Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]
CTD PMID:20361958 PMID:21633116 PMID:22119111 PMID:30247698 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Nicotine results in increased expression of CHD2 mRNA CTD PMID:16949557 NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:136,599,900...136,710,335
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667
JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression
ISO
EXP
CHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]
Nicotine results in increased expression of CHGA mRNA
CTD PMID:1907749 PMID:12799369 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:127,460,854...127,472,237
JBrowse link
G Chgb chromogranin B increases expression EXP Nicotine results in increased expression of CHGB mRNA; Nicotine results in increased expression of CHGB protein CTD PMID:1907749 NCBI chr 3:140,496,712...140,510,057
Ensembl chr 3:140,495,951...140,510,054
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions
affects binding
ISO PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein] CTD PMID:19690163 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:78,862,286...78,877,353
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit increases expression EXP Nicotine results in increased expression of CHRNA10 mRNA CTD PMID:30959089 PMID:31846720 NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:165,899,261...165,903,458
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit affects response to substance
multiple interactions
ISO
EXP
CHRNA2 gene mutant form affects the susceptibility to Nicotine
nicotine affects binding to Chrna2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina
nicotine affects binding competes with [Epibatidine binds to Chrna2 protein]
Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
CTD
RGD
PMID:9454827 PMID:19383498 PMID:16129735 PMID:15016836 RGD:2303195, RGD:2303194 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:44,517,862...44,534,144
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression
multiple interactions
increases activity
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA3 mRNA
nicotine affects binding [Epibatidine binds to Chrna3 protein]
Nicotine affects binding [Epibatidine binds to Chrna3 protein]
Nicotine results in increased activity of CHRNA3 protein
Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
Nicotine results in increased expression of CHRNA3 mRNA
CHRNA3 protein affects the susceptibility to Nicotine
CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
CTD
RGD
PMID:9454827 PMID:10336510 PMID:11600638 PMID:12628473 PMID:15275829 More... RGD:2303195, RGD:2303194 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
increases expression
multiple interactions
decreases expression
increases response to substance
affects response to substance
ISO
EXP
Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
nicotine increases expression of Chrna4 protein in prefrontal cortex, striatum and hippocampus
nicotine affects binding to Chrna4 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
nicotine affects binding to Chrna4 protein; nicotine competes with [Epibatidine binds to Chrna4 protein]
Nicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 protein
Nicotine results in decreased expression of CHRNA4 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CHRNA4 protein mutant form results in increased susceptibility to Nicotine
CHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to Nicotine
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD
RGD
PMID:7756618 PMID:9336329 PMID:9454827 PMID:10336510 PMID:10377228 More... RGD:598154614, RGD:2303195, RGD:2303194 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit increases response to substance
increases expression
affects response to substance
decreases expression
multiple interactions
ISO CHRNA5 gene polymorphism results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA
CHRNA5 gene polymorphism affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA; Nicotine results in increased expression of CHRNA5 protein
Nicotine results in decreased expression of CHRNA5 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]
CTD PMID:9495872 PMID:12628473 PMID:18450646 PMID:18519132 PMID:24793809 More... NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:64,265,879...64,294,233
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression
affects binding
multiple interactions
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA6 mRNA
nicotine binds to Chrna6 protein
nicotine inhibits the reaction [alpha-Conotoxin MII binds to Chrna6]; nicotine inhibits the reaction [epibatidine binds to Chrna6].
Nicotine results in increased expression of CHRNA6 mRNA
Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]
CHRNA6 gene polymorphism affects the susceptibility to Nicotine
CTD
RGD
PMID:10734154 PMID:12628473 PMID:17227438 PMID:29293602 PMID:30959089 More... RGD:8549526, RGD:8549526 NCBI chr16:71,400,615...71,407,315
Ensembl chr16:71,400,615...71,407,315
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
increases expression
affects binding
affects activity
increases activity
decreases expression
multiple interactions
affects response to substance
ISO
EXP
CHRNA7 protein mutant form results in increased susceptibility to Nicotine
nicotine increases expression of Chrna7 protein in prefrontal cortex and striatum
nicotine affects binding of the neuronal nicotinic acetylcholine receptor Chrna7 in rat hippocampal neurons
Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine affects the activity of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein
Nicotine results in decreased expression of CHRNA7 mRNA; Nicotine results in decreased expression of CHRNA7 protein
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Nicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein
[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine
CHRNA7 gene polymorphism affects the susceptibility to Nicotine; CHRNA7 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7; Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein; Nicotine results in increased activity of CHRNA7 protein mutant form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]; Nicotine binds to and results in increased activity of CHRNA7 protein; Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein; Pyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]
CTD
RGD
PMID:9336329 PMID:9495872 PMID:10082212 PMID:10216184 PMID:10942032 More... RGD:598154614, RGD:1600992 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit increases expression
multiple interactions
ISO Nicotine results in increased expression of CHRNA9 mRNA
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein
CTD PMID:29486207 PMID:30259641 PMID:30959089 PMID:31846720 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,588,948...42,595,669
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression
decreases expression
affects binding
affects response to substance
ISO
EXP
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
nicotine increases expression of Chrnb2 protein in prefrontal cortex, striatum and hippocampus
nicotine affects binding to Chrnb2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
nicotine affects binding to Chrnb2 protein; nicotine competes with [Epibatidine binds to Chrnb2 protein]
Nicotine results in increased expression of CHRNB2 mRNA
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in decreased expression of CHRNB2 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA; Nicotine results in increased expression of CHRNB2 protein
CHRNB2 protein affects the susceptibility to Nicotine
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD
RGD
PMID:7756618 PMID:9336329 PMID:10336510 PMID:10377228 PMID:10945867 More... RGD:598154614, RGD:2303195, RGD:2303194 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression
multiple interactions
EXP Nicotine results in increased expression of CHRNB3 mRNA
nicotine affects binding to Chrnb3 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina
CTD
RGD
PMID:30959089 PMID:16129735 RGD:2303195 NCBI chr16:71,411,847...71,454,225
Ensembl chr16:71,417,039...71,454,225
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions
increases expression
increases activity
affects response to substance
ISO
EXP
Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
Nicotine results in increased expression of CHRNB4 mRNA
Nicotine results in increased activity of CHRNB4 protein
Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CHRNB4 protein affects the susceptibility to Nicotine
CTD PMID:9454827 PMID:11600638 PMID:15275829 PMID:15615518 PMID:19483072 More... NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Nicotine results in decreased expression of CIAO1 mRNA CTD PMID:11478936 NCBI chr 3:134,913,639...134,919,244
Ensembl chr 3:134,913,172...134,979,255
JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CIB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CIB1 mRNA] CTD PMID:20230807 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:143,587,021...143,593,326
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Nicotine results in decreased expression of CIDEA mRNA CTD PMID:33091441 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Nicotine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:10,184,515...10,189,623 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CKMT1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:128,783,597...128,789,483
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression ISO Nicotine results in decreased expression of CKMT2 mRNA CTD PMID:16949557 NCBI chr 2:24,815,008...24,845,511
Ensembl chr 2:24,815,008...24,845,511
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO Nicotine results in decreased expression of CKS1B mRNA CTD PMID:18247414 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:177,130,777...177,135,365
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO Nicotine results in increased expression of CKS2 mRNA CTD PMID:16949557 NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CLCA2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLCA2 mRNA] CTD PMID:20230807 NCBI chr 2:236,655,419...236,682,669
Ensembl chr 2:236,639,545...236,685,129
JBrowse link
G Clcc1 chloride channel CLIC-like 1 increases expression ISO Nicotine results in increased expression of CLCC1 mRNA CTD PMID:16949557 NCBI chr 2:198,984,455...199,015,015
Ensembl chr 2:198,984,495...199,015,014
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Nicotine results in increased expression of CLCN3 mRNA CTD PMID:16949557 NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984
JBrowse link
G Cldn4 claudin 4 decreases expression
increases expression
ISO Nicotine results in decreased expression of CLDN4 protein
Nicotine results in increased expression of CLDN4 protein
CTD PMID:31783125 NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Nicotine results in decreased expression of CLIC1 mRNA CTD PMID:16949557 NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367
JBrowse link
G Clmp CXADR-like membrane protein increases expression ISO Nicotine results in increased expression of CLMP mRNA CTD PMID:23825647 NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:49,957,720...50,065,959
JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:165,314,128...165,377,627
Ensembl chr 5:165,314,309...165,377,625
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 decreases expression ISO Nicotine results in decreased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:32,382,171...32,385,288
Ensembl chr15:32,382,608...32,385,271
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:10,363,102...10,370,312
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance
increases expression
multiple interactions
ISO CNR1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CNR1 mRNA
[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine
CTD PMID:12384171 PMID:16416159 PMID:21955143 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
JBrowse link
G Cntn1 contactin 1 multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] CTD PMID:12588870 PMID:16949557 NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:125,142,696...125,440,391
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
increases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Nicotine promotes the reaction [Thioacetamide results in increased expression of COL1A1]
Nicotine results in decreased expression of COL1A1 mRNA; Nicotine results in decreased expression of COL1A1 protein
Nicotine results in increased expression of COL1A1 mRNA; Nicotine results in increased expression of COL1A1 protein
CTD PMID:20230807 PMID:28440100 PMID:33082140 PMID:33640489 PMID:34153408 More... NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP
ISO
Nicotine promotes the reaction [Arginine results in increased expression of COL1A2 protein]
Nicotine promotes the reaction [Quartz results in increased expression of COL1A2 protein]
CTD PMID:34153408 PMID:36868510 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of COL2A1 mRNA; Nicotine results in decreased expression of COL2A1 protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of COL3A1 mRNA
Nicotine promotes the reaction [Arginine results in increased expression of COL3A1 protein]
Nicotine results in increased expression of COL3A1 mRNA; Nicotine results in increased expression of COL3A1 protein
NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]
CTD PMID:33082140 PMID:34153408 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL6A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL6A1 mRNA] CTD PMID:20230807 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107
JBrowse link
G Cort cortistatin affects expression
decreases expression
EXP Nicotine affects the expression of CORT protein
Nicotine results in decreased expression of CORT protein
CTD PMID:22975262 PMID:26776438 PMID:28555334 NCBI chr 5:164,843,682...164,845,796 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of COX7A2L mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:16,936,795...16,950,798
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:18,577,145...18,579,170
Ensembl chr 2:18,577,149...18,579,170
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO Nicotine results in decreased expression of CRABP2 mRNA CTD PMID:16949557 NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:175,707,312...175,728,385
JBrowse link
G Crct1 cysteine-rich C-terminal 1 increases expression ISO Nicotine results in increased expression of CRCT1 mRNA CTD PMID:23825647 NCBI chr 2:181,329,392...181,330,877
Ensembl chr 2:181,329,392...181,330,877
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
increases phosphorylation
decreases expression
ISO
EXP
CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of CREB1 mRNA
Nicotine results in increased phosphorylation of CREB1 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]; Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nicotine results in decreased expression of CREB1 mRNA
CTD PMID:18247414 PMID:21113126 PMID:25847246 PMID:31945395 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Nicotine results in increased expression of CREB3 mRNA CTD PMID:31945395 NCBI chr 5:62,613,652...62,619,019
Ensembl chr 5:62,613,638...62,619,500
JBrowse link
G Creb5 cAMP responsive element binding protein 5 increases expression ISO Nicotine results in increased expression of CREB5 mRNA CTD PMID:31945395 NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:83,723,194...84,120,793
JBrowse link
G Crebbp CREB binding protein increases expression ISO Nicotine results in increased expression of CREBBP mRNA CTD PMID:31945395 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266
JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of CRH mRNA; Nicotine results in decreased expression of CRH protein
Nicotine results in increased expression of CRH protein
CTD PMID:21955143 PMID:22265867 PMID:23623838 PMID:28555334 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Nicotine results in decreased expression of CRYAB mRNA CTD PMID:21955143 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528
JBrowse link
G Cs citrate synthase multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA CTD PMID:33091441 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Nicotine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:115,332,128...115,346,596
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
ISO Nicotine results in increased expression of and results in increased secretion of CSF2 protein; Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 PMID:18082304 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Csn2 casein beta multiple interactions ISO Nicotine results in decreased expression of and results in decreased secretion of CSN2 protein CTD PMID:31783125 NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,601,824...20,609,060
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions
increases expression
ISO CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] CTD PMID:35929799 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CST3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of CTNNB1 mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
nuciferine inhibits the reaction [Nicotine results in increased expression of CTNNB1 protein]
Nicotine results in increased expression of CTNNB1 mRNA; Nicotine results in increased expression of CTNNB1 protein
CTD PMID:25698245 PMID:33640489 PMID:35411647 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] CTD PMID:20230807 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
JBrowse link
G Ctsh cathepsin H increases expression ISO Nicotine results in increased expression of CTSH mRNA CTD PMID:23825647 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CTSL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Nicotine results in decreased expression of CXCL2 mRNA CTD PMID:18247414 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion
increases expression
ISO Nicotine results in decreased expression of CXCL1 mRNA
Nicotine results in decreased secretion of CXCL1 protein
Nicotine results in increased expression of CXCL1 protein
CTD PMID:16254210 PMID:22093924 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression
increases expression
ISO Nicotine results in decreased expression of CXCR2 mRNA
Nicotine results in increased expression of CXCR2 mRNA
CTD PMID:18247414 PMID:20457658 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Nicotine results in increased expression of CXCR3 mRNA CTD PMID:20457658 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:70,883,958...70,886,871
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
increases expression
ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]
Nicotine results in increased expression of CXCR4 mRNA; Nicotine results in increased expression of CXCR4 protein
CTD PMID:20457658 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
increases secretion
affects localization
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]
Nicotine results in increased expression of CYCS protein
Nicotine results in increased secretion of CYCS protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein]
Nicotine affects the localization of CYCS protein
Nicotine results in decreased secretion of CYCS protein
CTD PMID:11701223 PMID:15985439 PMID:18203686 PMID:29972271 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
decreases activity
multiple interactions
ISO
EXP
Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein
Nicotine results in decreased activity of CYP11A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]
CTD PMID:20230807 PMID:21971485 PMID:22265867 PMID:24709674 PMID:28986172 More... NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Nicotine results in decreased expression of CYP11B1 mRNA CTD PMID:24709674 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO
EXP
Nicotine results in decreased expression of CYP17A1 mRNA
Nicotine results in decreased expression of CYP17A1 mRNA; Nicotine results in decreased expression of CYP17A1 protein
CTD PMID:24709674 PMID:27782041 PMID:28986172 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases activity
EXP
ISO
Nicotine results in decreased expression of CYP19A1 mRNA; Nicotine results in decreased expression of CYP19A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP19A1 protein]
Nicotine results in increased activity of CYP19A1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]
CTD PMID:30959089 PMID:32113805 PMID:35577041 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of CYP1A1 mRNA; Nicotine results in increased expression of CYP1A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1A1 protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SR 11302 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]
CTD PMID:11849738 PMID:22498344 PMID:34171359 PMID:35577041 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
decreases activity
ISO
EXP
Nicotine results in increased expression of CYP1A2 protein
Nicotine results in decreased expression of CYP1A2 mRNA
Nicotine results in decreased activity of CYP1A2 protein
CTD PMID:11849738 PMID:15916432 PMID:26463278 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of CYP1B1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1B1 protein]
CTD PMID:35577041 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Nicotine results in decreased expression of CYP26A1 mRNA; Nicotine results in decreased expression of CYP26A1 protein CTD PMID:21371177 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
increases hydroxylation
multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
Nicotine results in increased expression of CYP2A1 mRNA
CYP2A6 protein results in increased hydroxylation of Nicotine
Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]
Nicotine results in decreased activity of CYP2A13 protein
CYP2A13 protein results in increased metabolism of Nicotine
CTD PMID:12919726 PMID:22743290 PMID:22934830 PMID:27567546 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression EXP Nicotine results in increased expression of CYP2A2 mRNA CTD PMID:22934830 NCBI chr 1:91,391,492...91,417,158
Ensembl chr 1:91,391,502...91,417,158
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Nicotine results in increased expression of CYP2A3 mRNA CTD PMID:14972772 PMID:22934830 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
increases expression
EXP CYP2B1 protein results in increased metabolism of Nicotine
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP2B1 mRNA; [Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine; [Nicotine results in increased expression of CYP2B1 protein] which results in increased metabolism of Nicotine; Nicotine results in increased expression of and results in increased activity of CYP2B1 protein
Nicotine results in increased expression of CYP2B1 mRNA; Nicotine results in increased expression of CYP2B1 protein
CTD PMID:10799646 PMID:14972772 PMID:20599831 PMID:26463278 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing
affects oxidation
increases oxidation
multiple interactions
ISO CYP2B6 protein results in increased metabolism of Nicotine
CYP2B6 gene polymorphism affects the oxidation of Nicotine
CYP2B6 protein results in increased oxidation of Nicotine
CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine]
CTD PMID:12488541 PMID:18004205 PMID:30906561 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases expression
ISO Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]
Nicotine results in increased expression of CYP2D22 mRNA; Nicotine results in increased expression of CYP2D22 protein
CTD PMID:19594327 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nicotine results in increased expression of CYP2E1 protein CTD PMID:16434548 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP3A2 mRNA
[Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA
CTD PMID:12851153 PMID:26463278 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Nicotine results in increased expression of CYP4F3 mRNA CTD PMID:23825647 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] CTD PMID:17498763 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316
JBrowse link
G Dbi diazepam binding inhibitor increases expression ISO nicotine increases expression of Dbi mRNA and protein in cerebral cortex and cortical neurons. RGD PMID:11750077 RGD:408356485 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450
JBrowse link
G Dcaf16 DDB1 and CUL4 associated factor 16 increases expression ISO Nicotine results in increased expression of DCAF16 mRNA CTD PMID:16949557 NCBI chr14:69,662,173...69,662,557 JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Nicotine results in decreased expression of DDB1 mRNA CTD PMID:16949557 NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:216,677,810...216,703,596
JBrowse link
G Ddhd2 DDHD domain containing 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA CTD PMID:28065790 NCBI chr16:73,022,136...73,051,746
Ensembl chr16:73,022,193...73,051,745
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]
CTD PMID:11592233 PMID:28082123 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Nicotine results in increased expression of DDIT4 mRNA CTD PMID:17456735 PMID:23825647 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO Nicotine results in increased expression of DDX17 mRNA CTD PMID:16949557 NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747
JBrowse link
G Dedd death effector domain-containing decreases expression ISO Nicotine results in decreased expression of DEDD mRNA CTD PMID:18247414 NCBI chr13:86,286,341...86,301,789
Ensembl chr13:86,288,350...86,302,446
JBrowse link
G Defb23 defensin beta 23 decreases expression ISO Nicotine results in decreased expression of DEFB129 mRNA CTD PMID:23825647 NCBI chr 3:161,383,615...161,390,685
Ensembl chr 3:161,383,319...161,388,004
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO Nicotine results in decreased expression of DFFB mRNA CTD PMID:18247414 NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Nicotine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 NCBI chr 2:25,320,895...25,346,004 JBrowse link
G Dhps deoxyhypusine synthase decreases expression ISO Nicotine results in decreased expression of DHPS mRNA CTD PMID:16949557 NCBI chr19:39,987,328...39,991,418
Ensembl chr19:39,987,324...39,991,432
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Nicotine results in increased expression of DHRS3 mRNA CTD PMID:23825647 NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:162,031,386...162,065,653
JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Nicotine results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:149,006,089...149,044,191
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
decreases methylation
ISO
EXP
Nicotine results in decreased expression of DLG4 mRNA
Nicotine results in decreased methylation of DLG4 gene
CTD PMID:21955143 PMID:28555334 PMID:32994467 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJB9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal decreases expression ISO Nicotine results in decreased expression of DNASE2 mRNA CTD PMID:18247414 NCBI chr19:40,149,505...40,152,225
Ensembl chr19:40,149,505...40,152,225
JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Nicotine results in increased expression of DNM1L protein CTD PMID:21554491 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of DNMT1 mRNA
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]
CTD PMID:28555334 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
EXP
ISO
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in decreased expression of DRD1 mRNA
CTD PMID:1833784 PMID:21955143 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases response to substance
EXP [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine
DRD2 mRNA results in decreased susceptibility to Nicotine
CTD PMID:1833784 PMID:24239691 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd3 dopamine receptor D3 increases expression ISO Nicotine results in increased expression of DRD3 protein CTD PMID:31945395 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression ISO Nicotine results in decreased expression of DTYMK mRNA CTD PMID:16949557 NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:101,762,899...101,774,504
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Nicotine results in increased expression of DUSP1 mRNA CTD PMID:17456735 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Nicotine results in decreased expression of DUSP11 mRNA CTD PMID:17456735 NCBI chr 4:119,928,533...119,942,643
Ensembl chr 4:119,928,537...119,942,567
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Nicotine results in increased expression of DUSP6 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of DVL2 mRNA
Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 protein]
Nicotine results in increased expression of DVL2 mRNA; Nicotine results in increased expression of DVL2 protein
CTD PMID:16949557 PMID:33640489 PMID:35411647 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:55,222,056...55,231,506
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Nicotine results in increased expression of DYNC1LI2 mRNA CTD PMID:16949557 NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] CTD PMID:16601104 PMID:16862215 PMID:20061081 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563
JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions ISO Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087
JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834
JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression EXP Nicotine results in increased expression of EBF2 mRNA CTD PMID:35026373 NCBI chr15:45,610,949...45,809,828
Ensembl chr15:45,610,949...45,809,822
JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ECM1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 protein
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]
CTD PMID:33082140 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Nicotine results in decreased expression of EDNRA mRNA CTD PMID:18247414 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284
JBrowse link
G Ednrb endothelin receptor type B increases activity EXP Nicotine results in increased activity of EDNRB protein CTD PMID:21316381 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of EEF2 protein modified form
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Nicotine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798
JBrowse link
G Efna2 ephrin A2 increases expression ISO Nicotine results in increased expression of EFNA2 mRNA CTD PMID:23825647 NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:10,167,091...10,177,719
JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EFNB3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,773,282...54,797,651
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in decreased expression of EGFR mRNA
Nicotine results in increased phosphorylation of EGFR protein
AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein]
CTD PMID:11478936 PMID:14569062 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein
Nicotine results in decreased expression of EGR1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA]
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]
CTD PMID:17456735 PMID:17997037 PMID:20230807 PMID:21955143 PMID:22198237 More... NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Egr2 early growth response 2 increases expression ISO Nicotine results in increased expression of EGR2 mRNA CTD PMID:17456735 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748
JBrowse link
G Egr3 early growth response 3 decreases expression ISO Nicotine results in decreased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression ISO Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF2B4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF2B4 mRNA] CTD PMID:20230807 NCBI chr 6:30,903,148...30,908,803
Ensembl chr 6:30,903,219...30,908,800
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Nicotine results in increased phosphorylation of EIF2S1 protein CTD PMID:26803847 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]
EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]
CTD PMID:20230807 PMID:30836163 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105
JBrowse link
G Eif4e3 eukaryotic translation initiation factor 4E family member 3 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of EIF4E3 mRNA CTD PMID:37951547 NCBI chr 4:133,709,802...133,858,398
Ensembl chr 4:133,625,768...133,885,647
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]; Nicotine results in increased expression of and results in increased phosphorylation of EIF4EBP1 protein CTD PMID:12511591 PMID:30836163 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases phosphorylation
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249
JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Nicotine results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:148,217,395...148,234,595
JBrowse link
G Emcn endomucin increases expression ISO Nicotine results in increased expression of EMCN mRNA CTD PMID:17456735 NCBI chr 2:228,564,445...228,644,370
Ensembl chr 2:228,564,430...228,645,155
JBrowse link
G Eml4 EMAP like 4 multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Nicotine results in increased expression of EMP1 mRNA CTD PMID:23825647 NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Nicotine results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721
JBrowse link
G Eng endoglin decreases expression ISO Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Nicotine results in increased expression of ENTPD3 mRNA CTD PMID:23825647 NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:129,124,709...129,156,252
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO Nicotine results in decreased expression of EPHA3 mRNA CTD PMID:18247414 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425
JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Nicotine results in decreased expression of EPHB3 mRNA CTD PMID:18247414 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775
JBrowse link
G Epo erythropoietin increases expression ISO Nicotine results in increased expression of EPO mRNA CTD PMID:18247414 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ERP44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:67,312,098...67,406,444
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO Nicotine results in increased expression of ERRFI1 mRNA CTD PMID:17456735 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Nicotine results in decreased expression of ESR1 mRNA CTD PMID:27552315 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ETFA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ETFA mRNA] CTD PMID:20230807 NCBI chr 8:64,731,192...64,787,965
Ensembl chr 8:64,731,193...64,788,080
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Nicotine results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:102,988,499...103,002,659
JBrowse link
G Ezr ezrin multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]
Nicotine results in increased expression of EZR mRNA
CTD PMID:18247414 PMID:20230807 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573
JBrowse link
G F2 coagulation factor II, thrombin increases expression ISO Nicotine results in increased expression of F2 mRNA CTD PMID:18805435 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Nicotine results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:28,706,501...28,712,473
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Nicotine results in increased expression of F3 mRNA CTD PMID:17997037 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369
JBrowse link
G Fah fumarylacetoacetate hydrolase increases expression ISO Nicotine results in increased expression of FAH mRNA CTD PMID:23825647 NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:147,957,935...147,981,046
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO Nicotine results in decreased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:19,038,726...19,060,644
Ensembl chr15:19,038,616...19,065,219
JBrowse link
G Fam120a family with sequence similarity 120 member A decreases expression ISO Nicotine results in decreased expression of FAM120A mRNA CTD PMID:17997037 NCBI chr17:15,890,151...15,981,337
Ensembl chr17:15,890,605...15,981,332
JBrowse link
G Fam83f family with sequence similarity 83, member F increases expression ISO Nicotine results in increased expression of FAM83F mRNA CTD PMID:23825647 NCBI chr 7:114,091,356...114,120,640
Ensembl chr 7:114,091,335...114,120,638
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
Nicotine results in increased expression of FAS mRNA; Nicotine results in increased expression of FAS protein CTD PMID:18203686 PMID:20383341 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Faslg Fas ligand affects expression
increases expression
EXP
ISO
Nicotine affects the expression of FASLG mRNA
Nicotine results in increased expression of FASLG mRNA; Nicotine results in increased expression of FASLG protein
Nicotine results in increased expression of FASLG protein alternative form
CTD PMID:18203686 PMID:18247414 PMID:19896492 PMID:20383341 PMID:20426880 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
JBrowse link
G Fasn fatty acid synthase increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of FASN mRNA; Nicotine results in increased expression of FASN protein
Nicotine affects the expression of FASN mRNA
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]
CTD PMID:24368177 PMID:29155039 PMID:31622651 PMID:31972234 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO Nicotine results in increased expression of FAT1 mRNA CTD PMID:16949557 NCBI chr16:53,909,759...54,029,175
Ensembl chr16:53,909,556...54,028,609
JBrowse link
G Fat2 FAT atypical cadherin 2 increases expression ISO Nicotine results in increased expression of FAT2 mRNA CTD PMID:23825647 NCBI chr10:39,864,765...39,957,027
Ensembl chr10:39,864,766...39,956,902
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Nicotine results in increased expression of FBN1 mRNA CTD PMID:17456735 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283
JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FBXL12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:27,445,823...27,457,772
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Nicotine results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:28,720,670...28,725,237
Ensembl chr 3:28,720,778...28,725,235
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of FEZ1 mRNA
alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form]; Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
CTD PMID:12588870 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:44,733,300...44,784,097
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
decreases expression
increases secretion
ISO
EXP
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]
Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]
Nicotine results in decreased expression of FGF2 protein
CTD PMID:9503263 PMID:9832142 PMID:14732461 PMID:15465631 PMID:16365874 More... NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein] CTD PMID:36868510 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Nicotine results in increased expression of FLRT2 mRNA CTD PMID:23825647 NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:120,507,689...120,609,004
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO Nicotine results in decreased expression of FLT3 mRNA CTD PMID:18247414 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Nicotine CTD PMID:12504349 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of FN1 mRNA
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Nicotine promotes the reaction [Quartz results in increased expression of FN1 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]
Nicotine results in increased expression of FN1 mRNA; Nicotine results in increased expression of FN1 protein
CTD PMID:18247414 PMID:18844224 PMID:33082140 PMID:36868510 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Folr1 folate receptor alpha increases expression ISO Nicotine results in increased expression of FOLR1 mRNA CTD PMID:19616087 NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
affects expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS protein
Nicotine results in increased phosphorylation of FOS protein
Nicotine deficiency affects the expression of FOS protein
Acetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein]
Nicotine results in decreased expression of FOS mRNA
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
CTD PMID:11425648 PMID:15857624 PMID:16251992 PMID:16690037 PMID:17003101 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
increases expression
ISO
EXP
Nicotine results in increased expression of FOSB mRNA
nicotine increases expression of Fosb protein in nucleus accumbens and dentate gyrus of hippocampal formation
nicotine increases expression of FosB protein in nucleus accumbens and caudate-putamen
Nicotine results in increased expression of FOSB protein
CTD
RGD
PMID:16949557 PMID:17324382 PMID:17456735 PMID:17333132 PMID:17468183 RGD:407571683, RGD:401900124 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein CTD PMID:12511591 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO Nicotine results in decreased expression of FOXP1 mRNA CTD PMID:21955143 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Nicotine results in decreased expression of FOXP3 protein CTD PMID:31629012 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894
JBrowse link
G Fpr1 formyl peptide receptor 1 increases expression EXP Nicotine results in increased expression of FPR1 protein CTD PMID:39824327 NCBI chr 1:67,417,991...67,429,813
Ensembl chr 1:67,421,313...67,422,520
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Nicotine results in decreased expression of SNL mRNA CTD PMID:18247414 NCBI chr12:16,710,601...16,723,734
Ensembl chr12:16,710,601...16,723,734
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Nicotine results in decreased expression of FSHB mRNA; Nicotine results in decreased expression of FSHB protein CTD PMID:20498001 PMID:28986172 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 increases expression ISO Nicotine results in increased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:95,414,556...95,418,645
Ensembl chr 1:95,414,557...95,418,591
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Nicotine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:95,405,071...95,414,407
Ensembl chr 1:95,405,225...95,414,345
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of FYN protein CTD PMID:17709503 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Nicotine results in decreased activity of G6PD protein CTD PMID:20498001 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144
JBrowse link
G Gab1 GRB2-associated binding protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA] CTD PMID:20230807 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Nicotine results in increased expression of GABRA3 mRNA CTD PMID:28339662 NCBI chr  X:155,301,979...155,543,870
Ensembl chr  X:155,303,928...155,543,863
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases expression EXP Nicotine results in increased expression of GABRA5 mRNA CTD PMID:28339662 NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:117,404,494...117,516,635
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Nicotine results in increased expression of GABRA6 mRNA CTD PMID:28339662 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:27,311,979...27,327,234
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Nicotine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
decreases methylation
multiple interactions
EXP Nicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 protein
Nicotine results in decreased methylation of GAD1 promoter
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]
CTD PMID:18312583 PMID:28555334 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Nicotine results in decreased expression of GAD2 mRNA CTD PMID:28555334 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression ISO Nicotine results in decreased expression of GAL mRNA CTD PMID:21955143 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Nicotine results in decreased expression of GALE mRNA CTD PMID:16949557 NCBI chr 5:153,477,420...153,481,926
Ensembl chr 5:153,478,325...153,481,922
JBrowse link
G Galk2 galactokinase 2 increases expression ISO Nicotine results in increased expression of GALK2 mRNA CTD PMID:17456735 NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:133,563,538...133,696,528
JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein] CTD PMID:23933227 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]
Nicotine results in increased expression of GATA2 mRNA; Nicotine results in increased expression of GATA2 protein
CTD PMID:18450646 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter] CTD PMID:24089524 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]
CTD PMID:20230807 PMID:24089524 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B increases expression ISO Nicotine results in increased expression of GATAD2B mRNA CTD PMID:33640489 NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:178,046,085...178,147,315
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Nicotine results in increased expression of GCH1 mRNA CTD PMID:16949557 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA] CTD PMID:20230807 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gcm1 glial cells missing transcription factor 1 decreases expression EXP Nicotine results in decreased expression of GCM1 mRNA; Nicotine results in decreased expression of GCM1 protein CTD PMID:24368670 NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:87,805,993...87,819,229
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Nicotine results in increased expression of GCNT2 mRNA
Nicotine results in decreased expression of GCNT2 mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989
JBrowse link
G Gdf1 growth differentiation factor 1 increases expression ISO Nicotine results in increased expression of GDF1 mRNA CTD PMID:18247414 NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,131,276...19,146,480
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Nicotine results in increased expression of GEM mRNA CTD PMID:17456735 NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
ISO Nicotine results in decreased expression of GFAP mRNA
Nicotine results in increased expression of GFAP mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Ggct gamma-glutamyl cyclotransferase increases splicing ISO Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:85,453,387...85,470,224
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein] CTD PMID:31857090 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050
JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GHITM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Nicotine results in increased expression of GJA1 mRNA; Nicotine results in increased expression of GJA1 protein CTD PMID:36720419 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Nicotine results in increased expression of GJA4 mRNA CTD PMID:28087314 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216
JBrowse link
G Gjc2 gap junction protein, gamma 2 increases expression ISO Nicotine results in increased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:44,462,203...44,470,924
Ensembl chr10:44,462,054...44,470,340
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO Nicotine results in increased expression of GLIPR1 mRNA CTD PMID:16949557 NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:49,373,581...49,384,640
JBrowse link
G Gm2a ganglioside GM2 activator increases expression
increases splicing
ISO Nicotine results in increased expression of GM2A mRNA
Nicotine results in increased splicing of GM2A mRNA alternative form
CTD PMID:23825647 NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:22,549,705...22,560,125
Ensembl chr15:22,547,034...22,560,308
JBrowse link
G Gnai2 G protein subunit alpha i2 increases splicing
multiple interactions
ISO Nicotine results in increased splicing of GNAI2 mRNA alternative form
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GNAI2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GNAI2 mRNA]
CTD PMID:20230807 PMID:23825647 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622
JBrowse link
G Gng10 G protein subunit gamma 10 increases expression ISO Nicotine results in increased expression of GNG10 mRNA CTD PMID:16949557 NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:78,651,167...78,658,059
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Nicotine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,977,681...32,983,121
Ensembl chr 4:32,977,664...32,984,438
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Nicotine results in decreased expression of GNRHR mRNA CTD PMID:28986172 NCBI chr14:22,211,666...22,229,654 JBrowse link
G Golga4 golgin A4 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] CTD PMID:16949557 NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603
JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:177,064,071...177,077,165
Ensembl chr 4:177,064,073...177,077,164
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA CTD PMID:28065790 NCBI chr10:89,085,323...89,105,665
Ensembl chr10:89,086,331...89,105,637
JBrowse link
G Gpatch2 G patch domain containing 2 increases splicing ISO Nicotine results in increased splicing of GPATCH2 mRNA alternative form CTD PMID:23825647 NCBI chr13:101,316,413...101,457,109
Ensembl chr13:101,316,413...101,457,109
JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Nicotine results in increased expression of GPNMB mRNA CTD PMID:23825647 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240
JBrowse link
G Gpr50 G protein-coupled receptor 50 increases expression
increases splicing
ISO Nicotine results in increased expression of GPR50 mRNA
Nicotine results in increased splicing of GPR50 mRNA alternative form
CTD PMID:23825647 NCBI chr  X:154,413,592...154,419,236
Ensembl chr  X:154,413,689...154,418,275
JBrowse link
G Gpr6 G protein-coupled receptor 6 increases expression ISO Nicotine results in increased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:46,072,480...46,075,251
Ensembl chr20:46,072,453...46,075,875
JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP Nicotine results in increased expression of GPR83 mRNA CTD PMID:27782041 NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:19,974,993...19,985,490
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Nicotine results in increased expression of GPR88 mRNA CTD PMID:21955143 NCBI chr 2:206,876,373...206,885,034
Ensembl chr 2:206,868,585...206,884,945
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 increases expression ISO Nicotine results in increased expression of GPRASP1 mRNA CTD PMID:17456735 NCBI chr  X:103,556,493...103,564,275
Ensembl chr  X:103,501,377...103,565,649
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B increases expression ISO Nicotine results in increased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:182,748,247...182,772,711
Ensembl chr 1:182,748,247...182,772,757
JBrowse link
G Gprc5c G protein-coupled receptor, class C, group 5, member C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPRC5C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPRC5C mRNA] CTD PMID:20230807 NCBI chr10:100,385,682...100,407,953
Ensembl chr10:100,383,631...100,426,962
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO
EXP
Nicotine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
Nicotine results in increased expression of GPT protein
nuciferine inhibits the reaction [Nicotine results in increased expression of GPT protein]
dexpanthenol inhibits the reaction [Nicotine results in increased expression of GPT protein]
CTD PMID:25698245 PMID:35411647 PMID:38229321 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of GPX1 mRNA
Nicotine results in increased expression of GPX1 protein
CTD PMID:16949557 PMID:18343235 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405
JBrowse link
G Gramd1b GRAM domain containing 1B increases expression ISO Nicotine results in increased expression of GRAMD1B mRNA CTD PMID:23825647 NCBI chr 8:49,551,642...49,790,965
Ensembl chr 8:49,556,332...49,791,052
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Nicotine inhibits the reaction [Ethanol increases phosphorylation of Gria1 protein in the prefrontal cortex, central amygdaloid nucleus] RGD PMID:27796078 RGD:405649737 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 decreases methylation EXP Nicotine results in decreased methylation of GRID1 gene CTD PMID:32994467 NCBI chr16:10,145,018...10,894,184
Ensembl chr16:10,144,964...10,891,946
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GRID2 mRNA; [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:93,745,277...95,219,868
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression ISO Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Nicotine results in decreased expression of GRM1 mRNA CTD PMID:28339662 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443
JBrowse link
G Grm2 glutamate metabotropic receptor 2 affects expression EXP Nicotine affects the expression of GRM2 mRNA CTD PMID:28339662 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:116,158,810...116,171,857
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression ISO Nicotine results in increased expression of GRM5 mRNA CTD PMID:21955143 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649
JBrowse link
G Gsdma gasdermin A increases expression ISO Nicotine results in increased expression of GSDMA mRNA CTD PMID:23825647 NCBI chr10:84,110,590...84,135,804
Ensembl chr10:84,123,314...84,135,804
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein
Nicotine results in increased expression of and results in decreased phosphorylation of GSK3A protein
Nicotine results in increased expression of GSK3A mRNA
CTD PMID:12511591 PMID:31945395 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein
Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B protein
Nicotine results in increased expression of GSK3B mRNA
Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:12511591 PMID:31945395 PMID:33640489 PMID:35411647 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP
ISO
Nicotine results in decreased activity of GSR protein CTD PMID:19778253 PMID:20498001 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression
multiple interactions
increases expression
increases activity
EXP
ISO
Nicotine results in decreased expression of GSTA4 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTA4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 protein]
Nicotine results in increased expression of GSTA4 mRNA
Nicotine results in increased activity of GSTA4 protein
CTD PMID:9774145 PMID:20230807 PMID:23933227 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Nicotine results in decreased expression of GSTK1 mRNA CTD PMID:17997037 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO Nicotine results in decreased expression of GSTM2 mRNA CTD PMID:33640489 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Guca1a guanylate cyclase activator 1A decreases expression ISO Nicotine results in decreased expression of GUCA1A mRNA CTD PMID:16949557 NCBI chr 9:21,080,782...21,096,221
Ensembl chr 9:21,086,642...21,096,221
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079
JBrowse link
G H2az2 H2A.Z variant histone 2 decreases expression ISO Nicotine results in decreased expression of H2AZ2 mRNA CTD PMID:17456735 NCBI chr14:85,507,228...85,526,166
Ensembl chr14:85,507,228...85,526,207
Ensembl chr16:85,507,228...85,526,207
JBrowse link
G H2bc14 H2B clustered histone 14 increases expression ISO Nicotine results in increased expression of H2BC5 protein CTD PMID:35929799 NCBI chr17:47,488,627...47,489,008 JBrowse link
G H2bc4 H2B clustered histone 4 decreases expression ISO Nicotine results in decreased expression of H2BC4 mRNA CTD PMID:17456735 NCBI chr17:47,388,085...47,392,349
Ensembl chr17:47,404,375...47,419,020
JBrowse link
G H3c1 H3 clustered histone 1 increases expression ISO Nicotine results in increased expression of H3C1 protein CTD PMID:35929799 NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,795,396...41,797,281
Ensembl chr17:41,795,396...41,797,281
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 decreases expression EXP
ISO
Nicotine results in decreased expression of HAND1 mRNA; Nicotine results in decreased expression of HAND1 protein CTD PMID:24368670 PMID:31507073 NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nicotine results in increased expression of HAVCR1 protein CTD PMID:21511693 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,841,763...15,842,603
JBrowse link
G Hdac1 histone deacetylase 1 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HDAC1 mRNA
Nicotine results in increased expression of HDAC1 mRNA; Nicotine results in increased expression of HDAC1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]
CTD PMID:24709674 PMID:34245815 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
decreases expression
EXP
ISO
Nicotine results in increased expression of HDAC2 mRNA; Nicotine results in increased expression of HDAC2 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
Nicotine results in decreased expression of HDAC2 protein
CTD PMID:24709674 PMID:31507073 PMID:31846720 PMID:34245815 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311
JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions
increases expression
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
Nicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 protein
CTD PMID:31846720 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Nicotine results in increased expression of HDAC7 mRNA CTD PMID:24709674 NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:130,803,013...130,841,017
JBrowse link
G Hddc2 HD domain containing 2 increases expression ISO Nicotine results in increased expression of HDDC2 mRNA CTD PMID:23825647 NCBI chr 1:28,100,669...28,133,008
Ensembl chr 1:28,083,521...28,132,977
JBrowse link
G Hells helicase, lymphoid specific multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] CTD PMID:20230807 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624
JBrowse link
G Hgf hepatocyte growth factor affects expression
decreases expression
multiple interactions
EXP
ISO
Nicotine affects the expression of HGF mRNA
Nicotine results in decreased expression of HGF protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA
CTD PMID:32512034 PMID:33091441 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of HIF1A protein
Nicotine results in decreased expression of HIF1A mRNA
resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]
CTD PMID:22687363 PMID:24793809 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]
Nicotine results in increased expression of HINT1 mRNA
CTD PMID:20230807 PMID:20514075 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HIPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HIPK1 mRNA] CTD PMID:20230807 NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:193,937,261...193,975,164
JBrowse link
G Hltf helicase-like transcription factor decreases expression ISO Nicotine results in decreased expression of HLTF mRNA CTD PMID:18247414 NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:104,478,772...104,538,818
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Nicotine results in decreased expression of HMGA1 mRNA CTD PMID:16949557 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
affects expression
ISO
EXP
Nicotine results in increased expression of HMGCR mRNA
Nicotine affects the expression of HMGCR mRNA
CTD PMID:23416264 PMID:31972234 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Nicotine results in increased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
affects expression
increases expression
multiple interactions
ISO
EXP
HMOX1 protein results in increased susceptibility to Nicotine
Nicotine affects the expression of HMOX1 mRNA
Nicotine results in increased expression of HMOX1 mRNA; Nicotine results in increased expression of HMOX1 protein
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]
CTD PMID:22954530 PMID:23933227 PMID:23942037 PMID:24095726 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 increases expression ISO Nicotine results in increased expression of HNRNPA3 mRNA CTD PMID:17456735 NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:80,985,969...80,996,043
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HNRNPC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:27,253,098...27,282,715
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 increases expression ISO Nicotine results in increased expression of HNRNPH2 mRNA CTD PMID:17456735 NCBI chr  X:102,074,175...102,080,115
Ensembl chr  X:102,074,179...102,081,025
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Nicotine results in decreased expression of HNRNPL mRNA CTD PMID:21955143 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Nicotine results in increased expression of HNRNPLL mRNA CTD PMID:17997037 NCBI chr 6:20,720,013...20,752,803
Ensembl chr 6:20,722,184...20,752,802
JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R increases expression ISO Nicotine results in increased expression of HNRNPR mRNA CTD PMID:17997037 NCBI chr 5:153,826,482...153,872,272
Ensembl chr 5:153,826,692...153,858,344
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Nicotine results in decreased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Nicotine results in increased expression of HOXB9 mRNA CTD PMID:23825647 NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,733,658...81,738,872
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 increases expression ISO Nicotine results in increased expression of HP1BP3 mRNA CTD PMID:16949557 NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:155,719,115...155,746,325
JBrowse link
G Hpca hippocalcin increases expression ISO Nicotine results in increased expression of HPCA mRNA CTD PMID:21955143 NCBI chr 5:146,739,978...146,750,961
Ensembl chr 5:146,739,978...146,749,983
JBrowse link
G Hpcal4 hippocalcin-like 4 increases expression ISO Nicotine results in increased expression of HPCAL4 mRNA CTD PMID:23825647 NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:140,739,635...140,751,530
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases activity
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]
Nicotine results in increased activity of HRAS protein
CTD PMID:15983034 PMID:20230807 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HSD11B1 mRNA
Nicotine affects the expression of HSD11B1 mRNA
ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
CTD PMID:21955143 PMID:22265867 PMID:26803847 PMID:31972234 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
affects expression
increases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of HSD11B2 mRNA; Nicotine results in decreased expression of HSD11B2 protein
Nicotine affects the expression of HSD11B2 mRNA
Nicotine results in increased expression of HSD11B2 mRNA; Nicotine results in increased expression of HSD11B2 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions
decreases expression
EXP
ISO
Taurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]
Nicotine results in decreased expression of HSD17B1 mRNA
Nicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 protein
CTD PMID:20498001 PMID:30959089 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression
EXP Nicotine results in decreased activity of HSD17B3 protein
Nicotine results in decreased expression of HSD17B3 mRNA; Nicotine results in decreased expression of HSD17B3 protein
CTD PMID:28986172 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases splicing ISO Nicotine results in increased splicing of HSD17B7 mRNA alternative form CTD PMID:23825647 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity
decreases expression
EXP
ISO
Nicotine results in decreased activity of HSD3B1 protein
Nicotine results in decreased expression of HSD3B1 mRNA
Nicotine results in decreased expression of HSD3B1 mRNA; Nicotine results in decreased expression of HSD3B1 protein
CTD PMID:28986172 PMID:30959089 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]
Nicotine results in increased expression of HSP90AA1 mRNA; Nicotine results in increased expression of HSP90AA1 protein
CTD PMID:12115584 PMID:20230807 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HSPA5
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:18477628 PMID:24201001 PMID:28082123 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of HTR1A protein
Nicotine decreases expression of Htr1a protein in the diencephalon
Nicotine results in increased expression of HTR1A protein
CTD
RGD
PMID:21324836 PMID:30247698 PMID:22921986 RGD:405850243 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] CTD PMID:21316381 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein; Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]
Nicotine results in increased expression of HTR2A protein
CTD PMID:21316381 PMID:30247698 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Nicotine results in decreased expression of IBSP mRNA CTD PMID:29981921 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Nicotine results in increased expression of ICAM1 protein CTD PMID:12575837 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Nicotine results in decreased expression of ID1 mRNA CTD PMID:17997037 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685
JBrowse link
G Id2 inhibitor of DNA binding 2 increases splicing ISO Nicotine results in increased splicing of ID2 mRNA alternative form CTD PMID:23825647 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Nicotine results in decreased expression of ID3 mRNA CTD PMID:17456735 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression
increases expression
ISO Nicotine results in decreased expression of IDI1 mRNA
Nicotine results in increased expression of IDI1 mRNA
CTD PMID:16949557 PMID:17997037 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression
multiple interactions
ISO Nicotine results in increased expression of IFI27 mRNA
Nicotine inhibits the reaction [nickel chloride results in increased expression of IFI27 mRNA]
CTD PMID:23825647 PMID:37951547 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781
JBrowse link
G Ifi44 interferon-induced protein 44 increases expression ISO Nicotine results in increased expression of IFI44 mRNA CTD PMID:23825647 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Nicotine results in increased expression of IFI44L mRNA CTD PMID:23825647 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] CTD PMID:31154625 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IFITM1 mRNA CTD PMID:37951547 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression ISO Nicotine results in decreased expression of IFNAR1 mRNA CTD PMID:18247414 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein] CTD PMID:31154625 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487
JBrowse link
G Ifng interferon gamma multiple interactions ISO Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA] CTD PMID:24095726 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of IGF1 mRNA; Nicotine results in decreased expression of IGF1 protein
Nicotine affects the expression of IGF1 mRNA; Nicotine affects the expression of IGF1 protein
Nicotine results in increased expression of IGF1 mRNA
IGF1 protein inhibits the reaction [Nicotine results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Nicotine results in increased expression of BAX protein]; Nicotine results in decreased expression of and results in decreased secretion of IGF1 protein; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]
CTD PMID:20960268 PMID:22265867 PMID:29486207 PMID:31972234 PMID:39207236 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
increases expression
EXP Nicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R protein
Nicotine affects the expression of IGF1R mRNA
Nicotine results in increased expression of IGF1R mRNA
CTD PMID:20426880 PMID:20960268 PMID:22265867 PMID:31972234 PMID:39207236 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP Nicotine results in increased expression of IGF2 mRNA CTD PMID:29486207 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667
JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 increases expression ISO Nicotine results in increased expression of IGF2BP2 mRNA CTD PMID:17997037 NCBI chr11:92,378,908...92,478,893
Ensembl chr11:92,378,908...92,478,867
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Nicotine results in increased expression of IGFBP2 mRNA CTD PMID:23825647 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Nicotine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:133,947,717...133,963,154
Ensembl chr  X:133,947,429...133,962,962
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO Nicotine results in increased expression of IGSF3 mRNA CTD PMID:23825647 NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:191,500,045...191,588,249
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression EXP Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
decreases secretion
ISO Nicotine results in decreased expression of IL10 mRNA
Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Nicotine results in decreased secretion of IL10 protein
[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:18247414 PMID:21237301 PMID:29673796 PMID:31926917 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] CTD PMID:23199342 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
increases secretion
ISO
EXP
CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]
Nicotine results in increased expression of IL18 protein
Nicotine results in increased expression of IL18 mRNA
CTD PMID:35131329 PMID:39098741 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Nicotine results in increased expression of and results in increased secretion of IL1B protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]
Nicotine results in increased expression of IL1B mRNA
Nicotine results in decreased expression of IL1B protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Nicotine results in increased expression of IL1B mRNA; Nicotine results in increased expression of IL1B protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:15976189 PMID:16254210 PMID:18082304 PMID:19673871 PMID:20943775 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions
increases expression
EXP methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]
Nicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 protein
CTD PMID:27180639 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin] CTD PMID:27180639 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Nicotine results in decreased susceptibility to IL2 protein CTD PMID:15231866 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il33 interleukin 33 increases secretion
multiple interactions
ISO Nicotine results in increased secretion of IL33 protein
[Nicotine co-treated with Quartz] results in increased expression of IL33 protein
Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of IL33 protein]
CTD PMID:29673796 PMID:36868510 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha decreases expression ISO Nicotine results in decreased expression of IL3RA mRNA CTD PMID:18247414 NCBI chr12:21,431,848...21,437,336
Ensembl chr12:21,431,848...21,437,250
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of IL4RA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] CTD PMID:20230807 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
decreases secretion
decreases expression
increases expression
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Nicotine results in increased expression of and results in increased secretion of IL6 protein; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]
Nicotine results in increased secretion of IL6 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA
Nicotine results in decreased secretion of IL6 protein
Nicotine results in decreased expression of IL6 mRNA; Nicotine results in decreased expression of IL6 protein
Nicotine results in increased expression of IL6 mRNA; Nicotine results in increased expression of IL6 protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]
CTD PMID:18082304 PMID:19673871 PMID:20943775 PMID:22093924 PMID:23199342 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Il7 interleukin 7 multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL7 protein CTD PMID:18082304 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389
JBrowse link
G Il9 interleukin 9 decreases expression ISO Nicotine results in decreased expression of IL9 mRNA CTD PMID:18247414 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,117,028...8,120,151
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 decreases expression ISO Nicotine results in decreased expression of INPPL1 mRNA CTD PMID:17456735 NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:165,595,063...165,609,503
JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression
EXP
ISO
Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein]
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
CTD PMID:29155039 PMID:31857090 PMID:33091441 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Ins2 insulin 2 increases expression EXP Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Insig1 insulin induced gene 1 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of INSIG1 mRNA
Nicotine results in decreased expression of INSIG1 mRNA
CTD PMID:23416264 PMID:26776438 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778
JBrowse link
G Insr insulin receptor decreases expression EXP Nicotine results in decreased expression of INSR mRNA; Nicotine results in decreased expression of INSR protein CTD PMID:20960268 PMID:22265867 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825
JBrowse link
G Irf6 interferon regulatory factor 6 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IRF6 mRNA CTD PMID:37951547 NCBI chr13:107,200,876...107,220,083
Ensembl chr13:107,200,731...107,220,049
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA] CTD PMID:31154625 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023
JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of IRF8 mRNA
[nickel chloride co-treated with Nicotine] results in increased expression of IRF8 mRNA
CTD PMID:17456735 PMID:37951547 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Nicotine results in increased expression of IRF9 mRNA CTD PMID:33640489 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538
JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:31,384,803...31,388,241
Ensembl chr19:31,384,833...31,388,238
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA] CTD PMID:31154625 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of ISG20 mRNA CTD PMID:37951547 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401
JBrowse link
G Itga2b integrin subunit alpha 2b decreases expression ISO Nicotine results in decreased expression of ITGA2B mRNA; Nicotine results in decreased expression of ITGA2B protein CTD PMID:21385097 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Nicotine results in decreased expression of ITGAL mRNA CTD PMID:18247414 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Nicotine results in increased expression of ITGAV mRNA CTD PMID:17997037 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Nicotine results in decreased expression of ITGB1 protein CTD PMID:11338295 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269
JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Nicotine results in decreased expression of ITGB3 mRNA; Nicotine results in decreased expression of ITGB3 protein CTD PMID:21385097 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression EXP Nicotine results in increased expression of ITGB5 mRNA CTD PMID:20426880 NCBI chr11:80,333,588...80,449,373
Ensembl chr11:80,333,590...80,449,373
JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:54,955,549...54,978,455
Ensembl chr15:54,955,552...54,978,455
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B increases expression EXP Nicotine results in increased expression of ITPKB mRNA CTD PMID:11478936 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:94,601,167...94,696,179
JBrowse link
G Ivl involucrin decreases expression ISO Nicotine results in decreased expression of IVL protein CTD PMID:16011614 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578
JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Nicotine results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:148,147,229...148,151,915
JBrowse link
G Jak2 Janus kinase 2 increases response to substance
increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
JAK2 results in increased susceptibility to Nicotine
Nicotine results in increased phosphorylation of JAK2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of JAK2 protein]
Nicotine results in decreased expression of JAK2 mRNA
CTD PMID:20943775 PMID:29155039 PMID:34153408 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of JMJD6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of JMJD6 mRNA] CTD PMID:20230807 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Nicotine results in increased expression of JUN protein
Nicotine results in increased phosphorylation of JUN protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA]
CTD PMID:11592233 PMID:17003101 PMID:17021677 PMID:21511693 PMID:34890707 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Nicotine results in increased expression of JUNB mRNA
Nicotine results in decreased expression of JUNB mRNA
CTD PMID:17456735 PMID:17997037 PMID:18805435 PMID:21955143 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218
JBrowse link
G Kat6b lysine acetyltransferase 6B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KAT6B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KAT6B mRNA] CTD PMID:20230807 NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases expression ISO Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP Nicotine results in decreased expression of KCNK1 mRNA CTD PMID:11478936 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051
JBrowse link
G Kdm7a lysine demethylase 7A increases expression ISO Nicotine results in increased expression of KDM7A mRNA CTD PMID:16949557 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:68,871,677...68,931,506
JBrowse link
G Kdr kinase insert domain receptor increases expression
decreases expression
EXP Nicotine results in increased expression of KDR mRNA
Nicotine results in decreased expression of KDR protein
CTD PMID:32512034 PMID:33091441 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Kif21b kinesin family member 21B increases expression ISO Nicotine results in increased expression of KIF21B mRNA CTD PMID:23825647 NCBI chr13:50,127,842...50,177,822
Ensembl chr13:50,127,842...50,177,822
JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KIF3B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:162,218,621...162,258,191
Ensembl chr 3:162,218,682...162,258,581
JBrowse link
G Klf10 KLF transcription factor 10 decreases expression
increases expression
ISO Nicotine results in decreased expression of KLF10 mRNA
Nicotine results in increased expression of KLF10 mRNA
CTD PMID:17456735 PMID:17997037 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948
JBrowse link
G Klf11 KLF transcription factor 11 decreases expression ISO Nicotine results in decreased expression of KLF11 mRNA CTD PMID:18247414 NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:47,014,326...47,037,044
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Nicotine results in increased expression of KLF4 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592
JBrowse link
G Klk5 kallikrein related-peptidase 5 increases expression ISO Nicotine results in increased expression of KLK5 mRNA CTD PMID:23825647 NCBI chr 1:103,432,743...103,442,011
Ensembl chr 1:103,433,065...103,441,305
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] CTD PMID:12588870 NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:10,353,735...10,568,620
JBrowse link
G Kng1 kininogen 1 multiple interactions
decreases activity
EXP Capsaicin promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]; Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148
JBrowse link
G Krt15 keratin 15 increases expression ISO Nicotine results in increased expression of KRT15 mRNA CTD PMID:23825647 NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142
JBrowse link
G Krt80 keratin 80 increases expression ISO Nicotine results in increased expression of KRT80 mRNA CTD PMID:23825647 NCBI chr 7:134,341,951...134,363,872
Ensembl chr 7:134,341,956...134,364,211
JBrowse link
G Krt85 keratin 85 increases expression ISO Nicotine results in increased expression of KRT85 mRNA CTD PMID:23825647 NCBI chr 7:134,508,913...134,515,786
Ensembl chr 7:134,508,913...134,515,786
JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Nicotine results in increased expression of LAMB1 mRNA CTD PMID:16949557 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Nicotine results in decreased expression of LAMP2 protein CTD PMID:33010382 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675
JBrowse link
G Lce1b late cornified envelope 1B increases expression ISO Nicotine results in increased expression of LCE1B mRNA CTD PMID:23825647 NCBI chr 2:180,951,824...180,953,140 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of LCK protein CTD PMID:17709503 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 affects response to substance ISO LCP1 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr15:56,846,375...56,954,090
Ensembl chr15:56,847,433...56,954,092
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Nicotine results in increased expression of LDLR mRNA CTD PMID:23416264 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Ldlrad3 low density lipoprotein receptor class A domain containing 3 increases splicing ISO Nicotine results in increased splicing of LDLRAD3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:108,694,528...108,936,330
Ensembl chr 3:108,694,528...108,936,368
JBrowse link
G Lep leptin increases expression
decreases response to substance
EXP Nicotine results in increased expression of LEP protein
Nicotine results in decreased susceptibility to LEP protein
CTD PMID:23623838 PMID:29155039 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Nicotine results in increased expression of LEPR mRNA
Nicotine results in decreased expression of LEPR mRNA
CTD PMID:22265867 PMID:29155039 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
JBrowse link
G Lgals1 galectin 1 increases expression ISO Nicotine results in increased expression of LGALS1 mRNA CTD PMID:23825647 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases secretion
EXP
ISO
Nicotine results in decreased expression of LHB mRNA; Nicotine results in decreased expression of LHB protein
Nicotine results in increased secretion of LHB protein
CTD PMID:12893845 PMID:20498001 PMID:28986172 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO Nicotine results in increased expression of LIG4 mRNA CTD PMID:16949557 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:116,859,425...116,872,363
Ensembl chr 3:116,860,282...116,872,363
JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Nicotine results in decreased expression of LIPE mRNA CTD PMID:29155039 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
Nicotine results in increased expression of LITAF mRNA
CTD PMID:12588870 PMID:21955143 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930
JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO Nicotine results in decreased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:76,106,319...76,119,807
Ensembl chr  X:76,106,071...76,119,808
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Nicotine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 increases expression ISO Nicotine results in increased expression of LRRFIP1 mRNA CTD PMID:16949557 NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:99,039,614...99,167,779
JBrowse link
G Lrrtm4 leucine rich repeat transmembrane neuronal 4 increases methylation EXP Nicotine results in increased methylation of LRRTM4 gene CTD PMID:32994467 NCBI chr 4:114,103,783...114,894,696
Ensembl chr 4:114,103,870...114,109,726
JBrowse link
G Ltb lymphotoxin beta decreases expression ISO Nicotine results in decreased expression of LTB mRNA CTD PMID:18247414 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054
JBrowse link
G Ltf lactotransferrin decreases expression ISO Nicotine results in decreased expression of LTF mRNA CTD PMID:23825647 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA CTD PMID:28065790 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303
JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member decreases expression ISO Nicotine results in decreased expression of LYL1 mRNA CTD PMID:17456735 NCBI chr19:40,356,967...40,359,834
Ensembl chr19:40,354,819...40,359,834
JBrowse link
G Lysmd3 LysM domain containing 3 affects response to substance ISO LYSMD3 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr 2:13,669,465...13,675,622
Ensembl chr 2:13,669,429...13,678,643
JBrowse link
G Madd MAP-kinase activating death domain decreases expression ISO Nicotine results in decreased expression of MADD mRNA CTD PMID:18247414 NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:97,570,787...97,613,509
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression EXP Nicotine results in increased expression of MAP2K6 mRNA CTD PMID:20426880 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP2K7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in increased activity of MAPK1 protein
Nicotine results in increased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPK1 mRNA]
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Nicotine results in increased expression of MAPK1 protein modified form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with Ethanol] results in increased phosphorylation of MAPK1 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17459420 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression ISO Nicotine results in decreased expression of MAPK11 mRNA CTD PMID:17135361 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases expression ISO Nicotine results in decreased expression of MAPK13 mRNA CTD PMID:17135361 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK3 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
Nicotine results in decreased expression of MAPK3 protein
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA; Nicotine results in decreased expression of MAPK3 protein
Nicotine results in increased expression of MAPK3 protein modified form
Nicotine results in increased activity of MAPK3 protein
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17135361 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
increases expression
increases activity
ISO
EXP
Nicotine results in increased phosphorylation of MAPK8 protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
Nicotine results in increased expression of MAPK8 mRNA
Nicotine results in increased activity of MAPK8 protein
Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
CTD PMID:11592233 PMID:17021677 PMID:20426880 PMID:20727180 PMID:21511693 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Nicotine results in decreased expression of MAPK9 mRNA CTD PMID:26776438 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 increases expression ISO Nicotine results in increased expression of MAST2 mRNA CTD PMID:33640489 NCBI chr 5:135,013,006...135,152,195
Ensembl chr 5:135,012,058...135,152,161
JBrowse link
G Mbp myelin basic protein increases phosphorylation EXP Nicotine results in increased phosphorylation of MBP protein CTD PMID:15983034 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein]; [Nicotine results in increased phosphorylation of MCL1 protein] which results in increased expression of and results in increased stability of MCL1 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] CTD PMID:19903766 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 increases expression EXP Nicotine results in increased expression of MCMDC2 mRNA CTD PMID:27782041 NCBI chr 5:14,071,609...14,120,435
Ensembl chr 5:14,080,968...14,120,351
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 decreases expression ISO Nicotine results in decreased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:7,803,382...8,493,596
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of MDH2 protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of MDH2 protein]
CTD PMID:29972271 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791
JBrowse link
G Me1 malic enzyme 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA] CTD PMID:20230807 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275
JBrowse link
G Med24 mediator complex subunit 24 increases expression ISO Nicotine results in increased expression of MED24 mRNA CTD PMID:23825647 NCBI chr10:84,160,866...84,198,607
Ensembl chr10:84,160,866...84,186,379
JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Nicotine results in increased expression of MED28 mRNA CTD PMID:16949557 NCBI chr14:69,807,319...69,816,115
Ensembl chr14:69,807,319...69,816,115
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression EXP Nicotine affects the expression of MEF2C mRNA CTD PMID:20426880 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit increases expression ISO Nicotine results in increased expression of METTL3 mRNA CTD PMID:17456735 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487
JBrowse link
G Mgp matrix Gla protein multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein CTD PMID:19910445 NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859
JBrowse link
G Mir15b microRNA 15b decreases expression
increases methylation
ISO Nicotine results in decreased expression of MIR15B mRNA
Nicotine results in increased methylation of MIR15B gene
CTD PMID:33640489 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275
JBrowse link
G Mir98 microRNA 98 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of MIR98 mRNA
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of MIR98 mRNA]
CTD PMID:33082140 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:24,460,648...24,460,755
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO Nicotine results in decreased expression of MIRLET7B mRNA CTD PMID:33082140 NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:118,684,038...118,684,122
JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO Nicotine results in decreased expression of MIRLET7D mRNA CTD PMID:33082140 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,322,260...16,322,357
JBrowse link
G Mirlet7g microRNA let-7g decreases expression ISO Nicotine results in decreased expression of MIRLET7G mRNA CTD PMID:33082140 NCBI chr 8:115,701,020...115,701,107
Ensembl chr 8:115,701,007...115,701,115
JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO Nicotine results in decreased expression of MIRLET7I mRNA CTD PMID:33082140 NCBI chr 7:60,527,877...60,527,961 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
decreases expression
EXP
ISO
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]
[Nicotine co-treated with Quartz] results in increased expression of MKI67 protein
Nicotine results in increased expression of MKI67 protein
Nicotine results in decreased expression of MKI67 protein
CTD PMID:29501575 PMID:30959089 PMID:31678612 PMID:36868510 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
JBrowse link
G Mlph melanophilin increases expression ISO Nicotine results in increased expression of MLPH mRNA CTD PMID:23825647 NCBI chr 9:98,955,036...98,990,566
Ensembl chr 9:98,955,141...98,990,556
JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO Nicotine results in increased expression of MME mRNA CTD PMID:23825647 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
Nicotine results in increased expression of MMP1 mRNA; Nicotine results in increased expression of MMP1 protein
CTD PMID:17151781 PMID:18986645 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of MMP13 mRNA; Nicotine results in increased expression of MMP13 protein
NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]
Nicotine results in decreased expression of MMP13 mRNA
CTD PMID:17151781 PMID:34153408 PMID:39098741 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]
Nicotine results in decreased expression of MMP2 mRNA
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA
Nicotine results in decreased expression of MMP2 protein
Nicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 protein
CTD PMID:14569062 PMID:17151781 PMID:18986645 PMID:20448088 PMID:23825647 More... NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of MMP3 mRNA; Nicotine results in increased expression of MMP3 protein
CTD PMID:17151781 PMID:18986645 PMID:39098741 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression
affects response to substance
ISO CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 protein
MMP7 promoter SNP affects the susceptibility to Nicotine
CTD PMID:20061081 PMID:20230807 PMID:25847246 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of MMP9 mRNA; Nicotine results in increased expression of MMP9 protein
MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
Nicotine results in decreased expression of MMP9 protein
CTD PMID:14569062 PMID:20061081 PMID:20448088 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of MPO protein
Nicotine results in increased activity of MPO protein
Acetylcysteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; erdosteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; Nicotine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Vitamin E inhibits the reaction [Nicotine results in increased activity of MPO protein]
CTD PMID:15976189 PMID:17216608 PMID:23810507 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Nicotine results in decreased expression of MRM3 mRNA CTD PMID:17997037 NCBI chr10:61,594,155...61,623,659
Ensembl chr10:61,593,999...61,600,865
JBrowse link
G Mrpl10 mitochondrial ribosomal protein L10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MRPL10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL10 mRNA] CTD PMID:20230807 NCBI chr10:82,522,470...82,530,886
Ensembl chr10:82,522,297...82,530,873
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728
JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 decreases expression ISO Nicotine results in decreased expression of MRPL41 mRNA CTD PMID:17997037 NCBI chr 3:28,178,837...28,179,755
Ensembl chr 3:28,162,197...28,181,250
JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression ISO Nicotine results in increased expression of MRPL54 mRNA CTD PMID:17456735 NCBI chr 7:9,103,525...9,106,045
Ensembl chr 7:9,103,525...9,106,045
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:184,763,529...184,775,777
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Nicotine results in increased expression of MSMO1 mRNA CTD PMID:23416264 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445
JBrowse link
G Mst1 macrophage stimulating 1 decreases expression ISO Nicotine results in decreased expression of MST1 mRNA CTD PMID:18247414 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015
JBrowse link
G Msx1 msh homeobox 1 increases expression EXP Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 NCBI chr14:77,185,802...77,189,735
Ensembl chr14:77,185,802...77,189,735
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP Nicotine results in decreased expression of COX1 protein CTD PMID:28681937 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853
JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Nicotine results in increased expression of MT1E mRNA CTD PMID:23825647 NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO [Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein] CTD PMID:23933227 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080
JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MTCH1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:7,391,558...7,415,291
Ensembl chr20:7,391,565...7,415,042
JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:1,784,218...1,828,463
Ensembl chr14:1,783,627...1,828,414
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 increases expression ISO Nicotine results in increased expression of MTIF2 mRNA CTD PMID:16949557 NCBI chr14:107,465,719...107,486,663
Ensembl chr14:107,466,861...107,487,003
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
multiple interactions
increases phosphorylation
EXP
ISO
Nicotine results in decreased expression of MTOR mRNA
Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
Nicotine results in increased phosphorylation of MTOR protein
CTD PMID:26776438 PMID:30836163 PMID:31926917 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of MX1 mRNA CTD PMID:37951547 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO Nicotine results in decreased expression of MYBL2 mRNA CTD PMID:16949557 NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:172,116,550...172,153,221
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases activity
increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased activity of MYC protein
Nicotine results in increased expression of MYC protein
EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]
Nicotine results in decreased expression of MYC mRNA
Nicotine results in decreased activity of and results in decreased expression of MYC protein
CTD PMID:17135361 PMID:17459420 PMID:30836163 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Nicotine results in increased expression of MYH7 protein CTD PMID:25280790 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194
JBrowse link
G Myl6 myosin light chain 6 decreases expression ISO Nicotine results in decreased expression of MYL6 mRNA CTD PMID:16949557 NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:1,495,747...1,498,344
JBrowse link
G Myo5b myosin Vb decreases expression ISO Nicotine results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:70,313,717...70,613,918
Ensembl chr18:70,311,990...70,613,918
JBrowse link
G Myo9a myosin IXA increases expression ISO Nicotine results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:69,044,885...69,245,231
JBrowse link
G Myof myoferlin increases splicing ISO Nicotine results in increased splicing of MYOF mRNA alternative form CTD PMID:23825647 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768
JBrowse link
G Mypn myopalladin decreases expression EXP Nicotine results in decreased expression of MYPN mRNA CTD PMID:27782041 NCBI chr20:25,435,554...25,521,149
Ensembl chr20:25,435,554...25,521,149
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions EXP Nicotine inhibits the reaction [Acetic Acid results in decreased expression of NAMPT protein] CTD PMID:23810507 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544
JBrowse link
G Nanog Nanog homeobox increases expression
multiple interactions
ISO Nicotine results in increased expression of NANOG mRNA; Nicotine results in increased expression of NANOG protein
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of NANOG protein; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]
CTD PMID:23219715 PMID:30259641 PMID:31507073 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061
JBrowse link
G Ncam1 neural cell adhesion molecule 1 multiple interactions ISO [Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]
[nickel chloride co-treated with Nicotine] results in increased expression of NCAM1 mRNA
CTD PMID:23933227 PMID:37951547 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of NCF1 protein] CTD PMID:34171359 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Nicotine results in increased expression of NDUFA5 mRNA CTD PMID:16949557 NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 decreases expression EXP Nicotine results in decreased expression of NDUFAF2 mRNA CTD PMID:27782041 NCBI chr 2:41,269,141...41,380,895
Ensembl chr 2:41,269,141...41,380,763
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFB5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:117,447,035...117,461,590
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression EXP Nicotine results in decreased expression of NDUFB8 protein CTD PMID:28681937 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Nicotine results in increased expression of NEDD9 mRNA CTD PMID:17456735 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668
JBrowse link
G Nefm neurofilament medium chain increases expression ISO Nicotine results in increased expression of NEFM protein CTD PMID:20457658 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:46,535,517...46,541,163
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:177,618,314...177,747,380
JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases splicing ISO Nicotine results in increased splicing of NFE2L1 mRNA alternative form CTD PMID:23825647 NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
decreases expression
increases expression
ISO
EXP
Nicotine results in increased activity of NFKB1 protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of NFKB1 mRNA; Nicotine results in decreased expression of NFKB1 protein
Nicotine results in increased expression of NFKB1 mRNA
Vitamin K 3 inhibits the reaction [Nicotine results in increased activity of NFKB1 protein]
CTD PMID:16598845 PMID:17135361 PMID:27984197 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Aerosols co-treated with Nicotine] results in increased expression of NFKB2 mRNA CTD PMID:33469865 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
increases degradation
increases expression
ISO
EXP
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; NSC 74859 inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Nicotine results in increased phosphorylation of NFKBIA protein
Nicotine results in increased degradation of NFKBIA protein
Nicotine results in increased expression of NFKBIA mRNA
CTD PMID:17021677 PMID:17456735 PMID:20943775 PMID:34171359 PMID:34890707 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO Nicotine results in decreased expression of NFKBIE mRNA CTD PMID:18247414 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta decreases expression ISO Nicotine results in decreased expression of NFYB mRNA CTD PMID:18247414 NCBI chr 7:22,852,543...22,868,116
Ensembl chr 7:22,852,546...22,882,294
JBrowse link
G Ngb neuroglobin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NGB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA] CTD PMID:20230807 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786
JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of NGF mRNA
Nicotine promotes the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]
Nicotine results in increased expression of NGF mRNA; Nicotine results in increased expression of NGF protein
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of NGF mRNA]
Nicotine results in increased expression of and results in increased secretion of NGF protein
CTD PMID:30076938 PMID:33082140 PMID:39505136 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Nicotine results in increased expression of NGFR mRNA CTD PMID:30076938 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305
JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO Nicotine results in decreased expression of NHERF2 mRNA CTD PMID:18247414 NCBI chr10:14,167,005...14,177,519
Ensembl chr10:14,167,005...14,177,593
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO Nicotine results in increased expression of NIBAN1 mRNA CTD PMID:23825647 NCBI chr13:66,224,219...66,377,728
Ensembl chr13:66,224,021...66,377,724
JBrowse link
G Nin ninein increases expression
multiple interactions
ISO Nicotine results in increased expression of NIN mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
CTD PMID:16949557 NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:94,263,206...94,363,610
JBrowse link
G Nkain3 Sodium/potassium transporting ATPase interacting 3 decreases methylation EXP Nicotine results in decreased methylation of NKAIN3 gene CTD PMID:35026373 NCBI chr 5:38,410,576...39,106,910
Ensembl chr 5:38,386,841...39,106,385
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of NLRP3 mRNA; Nicotine results in increased expression of NLRP3 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of NLRP3 mRNA]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
CTD PMID:35131329 PMID:39098741 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO Nicotine results in decreased expression of NME3 mRNA CTD PMID:18247414 NCBI chr10:14,421,922...14,422,878
Ensembl chr10:14,421,702...14,422,907
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 decreases expression ISO Nicotine results in decreased expression of NME6 mRNA CTD PMID:17997037 NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:118,711,036...118,718,288
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of NOS2 mRNA; Nicotine results in increased expression of NOS2 protein
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]
Nicotine results in decreased expression of NOS2 mRNA; Nicotine results in decreased expression of NOS2 protein
Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]
[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:16254210 PMID:16927020 PMID:17135361 PMID:18247414 PMID:19673871 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Nicotine results in increased expression of NOS3 mRNA CTD PMID:11166759 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Notch4 notch receptor 4 multiple interactions
decreases expression
EXP [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
Nicotine results in decreased expression of NOTCH4 protein
CTD PMID:20722969 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Nicotine results in increased expression of NOX4 protein CTD PMID:20685820 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
JBrowse link
G Npas3 neuronal PAS domain protein 3 decreases expression ISO Nicotine results in decreased expression of NPAS3 mRNA CTD PMID:23825647 NCBI chr 6:76,438,064...77,263,185
Ensembl chr 6:76,438,260...77,263,185
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:68,205,602...68,247,940
Ensembl chr13:68,205,603...68,247,999
JBrowse link
G Npy neuropeptide Y multiple interactions
decreases expression
increases expression
EXP Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA]
Nicotine results in decreased expression of NPY protein
Nicotine results in increased expression of NPY mRNA; Nicotine results in increased expression of NPY protein
CTD PMID:1907749 PMID:2233698 PMID:23623838 PMID:32512034 PMID:33091441 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
decreases expression
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]
Nicotine results in decreased expression of NR1H2 mRNA; Nicotine results in decreased expression of NR1H2 protein
CTD PMID:30036686 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
decreases expression
EXP
ISO
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]; Nicotine results in increased expression of and results in increased activity of NR1H3 protein
Nicotine results in decreased expression of NR1H3 mRNA; Nicotine results in decreased expression of NR1H3 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]
CTD PMID:24368177 PMID:30036686 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of NR3C1 mRNA
Nicotine results in decreased expression of NR3C1 protein
Nicotine results in increased expression of NR3C1 mRNA; Nicotine results in increased expression of NR3C1 protein
CTD PMID:22265867 PMID:22975262 PMID:31783125 PMID:31972234 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression EXP Nicotine results in decreased expression of NR3C2 mRNA CTD PMID:22975262 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
ISO Nicotine results in increased expression of NR4A1 mRNA
Nicotine results in decreased expression of NR4A1 mRNA
CTD PMID:17456735 PMID:21955143 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of NR5A1 mRNA; Nicotine results in decreased expression of NR5A1 protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]
CTD PMID:24709674 PMID:28986172 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Nicotine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,335,426...28,344,354
Ensembl chr17:28,334,616...28,344,354
JBrowse link
G Nrxn3 neurexin 3 increases expression
increases methylation
ISO
EXP
Nicotine results in increased expression of NRXN3 mRNA
Nicotine results in increased methylation of NRXN3 gene
CTD PMID:21955143 PMID:32994467 NCBI chr 6:113,372,667...115,004,073
Ensembl chr 6:113,443,524...115,002,540
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NSF mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621
JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression EXP Nicotine results in increased expression of NT5DC1 mRNA CTD PMID:27782041 NCBI chr20:39,660,707...39,763,647
Ensembl chr20:39,660,707...39,786,449
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Nicotine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:200,151,979...200,515,031
Ensembl chr 2:200,151,979...200,515,031
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of NTRK1 mRNA
Nicotine promotes the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]
CTD PMID:30076938 PMID:39505136 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of NTRK2 protein
[Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein]
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]
CTD PMID:16790237 PMID:36868510 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO Nicotine results in increased expression of NTSR1 mRNA CTD PMID:23825647 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:187,983,778...188,033,934
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Nicotine results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:32,075,002...32,091,491
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression
multiple interactions
ISO Nicotine results in increased expression of OAS1 mRNA
Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]
CTD PMID:23825647 PMID:31154625 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases activity
multiple interactions
EXP Nicotine results in decreased activity of OGDH protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of OGDH protein]
CTD PMID:29972271 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO OGG1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases expression ISO Nicotine results in increased expression of OGT mRNA CTD PMID:16949557 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:70,811,319...70,856,123
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO Nicotine results in decreased expression of OLFM4 mRNA CTD PMID:23825647 NCBI chr15:61,790,889...61,838,773
Ensembl chr15:61,671,271...61,838,764
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Nicotine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:249,840,539...249,858,423
Ensembl chr 1:249,840,539...249,858,190
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO [naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO Nicotine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 affects response to substance ISO OPRL1 protein affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of OR4D6 mRNA CTD PMID:28065790 NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:218,463,801...218,464,745
JBrowse link
G Orc2 origin recognition complex, subunit 2 increases expression ISO Nicotine results in increased expression of ORC2 mRNA CTD PMID:16949557 NCBI chr 9:67,496,097...67,532,548
Ensembl chr 9:67,496,825...67,526,649
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of P3H3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:159,332,514...159,348,428
Ensembl chr 4:159,332,434...159,348,004
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP Nicotine results in decreased expression of P4HB protein CTD PMID:28681937 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA] CTD PMID:20230807 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803
JBrowse link
G Pank3 pantothenate kinase 3 increases expression ISO Nicotine results in increased expression of PANK3 mRNA CTD PMID:16949557 NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,733,127...20,757,015
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA] CTD PMID:20230807 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
ISO
EXP
Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]
Nicotine results in decreased expression of PARP1 protein
Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein]
CTD PMID:20457658 PMID:22743290 PMID:24095863 PMID:29972271 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases splicing ISO Nicotine results in increased splicing of PARP4 mRNA alternative form CTD PMID:23825647 NCBI chr15:34,806,203...34,908,492
Ensembl chr15:34,816,701...34,944,433
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:118,177,565...118,480,301
JBrowse link
G Pax3 paired box 3 decreases expression EXP Nicotine results in decreased expression of PAX3 mRNA CTD PMID:20339300 NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:87,016,999...87,124,141
JBrowse link
G Pax6 paired box 6 decreases expression EXP Nicotine results in decreased expression of PAX6 mRNA CTD PMID:28555334 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763
JBrowse link
G Pax8 paired box 8 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of PAX8 mRNA
Nicotine results in decreased expression of PAX8 mRNA
CTD PMID:23825647 PMID:26776438 NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:27,584,002...27,640,631
JBrowse link
G Pcf11 PCF11 cleavage and polyadenylation factor subunit increases expression ISO Nicotine results in increased expression of PCF11 mRNA CTD PMID:17456735 NCBI chr 1:156,109,724...156,136,950
Ensembl chr 1:156,109,724...156,136,435
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of PCNA protein
Nicotine results in decreased expression of PCNA protein
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein]
CTD PMID:18448488 PMID:20106947 PMID:30896085 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Nicotine results in decreased expression of PDE10A mRNA CTD PMID:21955143 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051
JBrowse link
G Pdgfa platelet derived growth factor subunit A affects expression EXP Nicotine affects the expression of PDGFA mRNA CTD PMID:20426880 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
increases expression
increases secretion
ISO
EXP
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA]; 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein] CTD PMID:16149045 PMID:16254210 PMID:32512034 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PDGFRB protein
Nicotine results in decreased phosphorylation of and results in decreased activity of PDGFRB protein
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein]
CTD PMID:16149045 PMID:20447445 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PDIA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO Nicotine results in increased expression of PDK1 mRNA CTD PMID:31945395 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 increases expression ISO Nicotine results in increased expression of PDK2 mRNA CTD PMID:31945395 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355
JBrowse link
G Pdlim2 PDZ and LIM domain 2 increases expression ISO Nicotine results in increased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958
JBrowse link
G Pdyn prodynorphin increases expression
decreases expression
EXP chronic nicotine treatment increases pdyn mRNA in caudate-putamen and prefrontal cortex
chronic nicotine treatment decreases pdyn mRNA in nucleus accumbens
RGD PMID:27430399 PMID:27430399 RGD:616926599, RGD:616926599 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Penk proenkephalin affects response to substance ISO PENK protein affects the susceptibility to Nicotine CTD PMID:15689546 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Nicotine results in increased expression of PER1 mRNA CTD PMID:17456735 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 decreases expression ISO Nicotine results in decreased expression of PES1 mRNA CTD PMID:17997037 NCBI chr14:83,074,346...83,090,726
Ensembl chr14:83,074,319...83,091,718
JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:28,288,210...28,341,198
Ensembl chr18:28,287,913...28,341,123
JBrowse link
G Pfn1 profilin 1 decreases expression EXP Nicotine results in decreased expression of PFN1 mRNA CTD PMID:11478936 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611
JBrowse link
G Pgf placental growth factor increases expression EXP Nicotine results in increased expression of PGF mRNA CTD PMID:32512034 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747
JBrowse link
G Pgr progesterone receptor decreases expression ISO Nicotine results in decreased expression of PGR mRNA CTD PMID:27552315 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
JBrowse link
G Phb1 prohibitin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB1 mRNA] CTD PMID:20230807 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233
JBrowse link
G Phf21a PHD finger protein 21A increases expression ISO Nicotine results in increased expression of PHF21A mRNA CTD PMID:16949557 NCBI chr 3:98,600,933...98,791,132
Ensembl chr 3:98,613,844...98,787,350
JBrowse link
G Phf3 PHD finger protein 3 increases expression ISO Nicotine results in increased expression of PHF3 mRNA CTD PMID:16949557 NCBI chr 9:40,559,929...40,632,096
Ensembl chr 9:40,559,929...40,632,056
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO Nicotine results in increased expression of PHGDH mRNA CTD PMID:23825647 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 increases expression ISO Nicotine results in increased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:53,900,338...53,949,518
JBrowse link
G Phldb3 pleckstrin homology-like domain, family B, member 3 decreases expression EXP Nicotine results in decreased expression of PHLDB3 mRNA CTD PMID:27782041 NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:89,328,819...89,347,436
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 affects response to substance ISO PHLPP gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr13:22,823,132...23,045,619
Ensembl chr13:22,823,132...23,045,619
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHTF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA]
Nicotine results in decreased expression of PHTF1 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 2:194,161,343...194,249,925
Ensembl chr 2:194,161,000...194,219,530
JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Nicotine results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:112,677,322...112,697,257
JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Nicotine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:33,672,832...33,687,747
Ensembl chr  X:33,674,923...33,687,636
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:76,876,894...76,879,420
Ensembl chr13:76,872,922...76,880,224
JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F increases expression ISO Nicotine results in increased expression of PIGF mRNA CTD PMID:16949557 NCBI chr 6:13,343,134...13,371,237
Ensembl chr 6:13,342,869...13,393,214
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO Nicotine results in increased expression of PIK3CA mRNA CTD PMID:16949557 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PIN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA] CTD PMID:20230807 NCBI chr 8:27,465,538...27,477,016 JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of PKLR mRNA CTD PMID:28065790 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
G Pkn2 protein kinase N2 increases expression ISO Nicotine results in increased expression of PKN2 mRNA CTD PMID:16949557 NCBI chr 2:234,454,001...234,559,369
Ensembl chr 2:234,454,001...234,594,649
JBrowse link
G Pla2g12a phospholipase A2, group XIIA decreases expression ISO Nicotine results in decreased expression of PLA2G12A mRNA CTD PMID:17997037 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964
JBrowse link
G Pla2g4a phospholipase A2 group 4A decreases expression EXP Nicotine results in decreased expression of PLA2G4A mRNA CTD PMID:26776438 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Plaa phospholipase A2, activating protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PLAA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PLAA mRNA] CTD PMID:20230807 NCBI chr 5:114,544,327...114,576,023
Ensembl chr 5:114,544,325...114,576,109
JBrowse link
G Plat plasminogen activator, tissue type affects expression
increases expression
multiple interactions
ISO Nicotine affects the expression of PLAT mRNA
Nicotine results in increased expression of PLAT mRNA; Nicotine results in increased expression of PLAT protein
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA
CTD PMID:11166759 PMID:17151781 PMID:18986645 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]
PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein]
CTD PMID:19690163 PMID:20061081 PMID:23825647 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]
Nicotine results in increased expression of PLAUR mRNA; Nicotine results in increased expression of PLAUR protein
CTD PMID:20061081 PMID:22261521 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Nicotine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:83,564,606...83,606,454
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Nicotine results in increased phosphorylation of and results in increased activity of PLCG1 protein CTD PMID:15138183 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050
JBrowse link
G Pld1 phospholipase D1 decreases expression ISO Nicotine results in decreased expression of PLD1 mRNA CTD PMID:18247414 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245
JBrowse link
G Pld2 phospholipase D2 increases expression ISO Nicotine results in increased expression of PLD2 mRNA CTD PMID:18247414 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 affects response to substance
decreases expression
ISO PLEKHG1 gene SNP affects the susceptibility to Nicotine
Nicotine results in decreased expression of PLEKHG1 mRNA
CTD PMID:18438686 PMID:21955143 NCBI chr 1:42,612,023...42,841,727
Ensembl chr 1:42,612,122...42,841,719
JBrowse link
G Plin2 perilipin 2 decreases expression ISO Nicotine results in decreased expression of PLIN2 protein CTD PMID:31783125 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Nicotine results in increased expression of PLK2 mRNA CTD PMID:17456735 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296
JBrowse link
G Pllp plasmolipin increases expression ISO Nicotine results in increased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,321,080...10,342,226
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Nicotine results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:25,313,070...25,323,631
Ensembl chr12:25,313,072...25,323,631
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PNMT mRNA
Nicotine results in increased expression of PNMT protein
imidacloprid promotes the reaction [Nicotine results in increased expression of PNMT protein]
CTD PMID:17498763 PMID:29246838 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,881,185...83,882,849
JBrowse link
G Pnoc prepronociceptin affects response to substance
increases expression
ISO
EXP
PNOC protein alternative form affects the susceptibility to Nicotine
chronic nicotine treatment increases pnoc mRNA in ventral midbrain and prefrontal cortex
CTD
RGD
PMID:19371589 PMID:27430399 RGD:616926599 NCBI chr15:43,800,240...43,827,841
Ensembl chr15:43,800,246...43,827,470
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of PNPLA2 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein
CTD PMID:29155039 PMID:29617909 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359
JBrowse link
G Pnpla4 patatin like phospholipase domain containing 4 decreases expression ISO Nicotine results in decreased expression of PNPLA4 mRNA CTD PMID:16949557 NCBI chr  X:46,200,351...46,205,517
Ensembl chr  X:46,193,332...46,205,089
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:67,056,697...67,120,512
JBrowse link
G Pomc proopiomelanocortin affects response to substance
decreases expression
affects expression
multiple interactions
increases expression
ISO
EXP
POMC protein affects the susceptibility to Nicotine
Nicotine results in decreased expression of POMC protein
Nicotine affects the expression of POMC protein
POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]
Nicotine results in increased expression of POMC protein alternative form
CTD PMID:15689546 PMID:19376143 PMID:22975262 PMID:23623838 PMID:28555334 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO Nicotine results in decreased activity of PON1 protein
PON1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
CTD PMID:24478552 PMID:29747151 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Nicotine results in increased expression of PON2 mRNA CTD PMID:16949557 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996
JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO Nicotine results in decreased expression of POU2AF1 mRNA CTD PMID:18247414 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:60,436,844...60,445,176
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Nicotine results in increased expression of POU2F1 mRNA CTD PMID:18247414 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:80,663,714...80,796,356
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of POU5F1 mRNA; Nicotine results in increased expression of POU5F1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 PMID:23219715 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
JBrowse link
G Ppan peter pan homolog increases expression ISO Nicotine results in increased expression of PPAN mRNA CTD PMID:17456735 NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:27,700,152...27,704,128
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Nicotine results in decreased expression of PPARA mRNA CTD PMID:29155039 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Nicotine results in increased expression of PPARG mRNA
Nicotine results in decreased expression of PPARG protein
CTD PMID:31622651 PMID:33082140 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of PPARGC1A mRNA; Nicotine results in decreased expression of PPARGC1A protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein
CTD PMID:29155039 PMID:33091441 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PPM1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression ISO Nicotine results in increased expression of PPP2R3A mRNA CTD PMID:16949557 NCBI chr 8:110,582,479...110,720,516
Ensembl chr 8:110,583,743...110,677,482
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:78,382,849...78,406,037
Ensembl chr 6:78,382,855...78,406,201
JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta decreases expression ISO Nicotine results in decreased expression of PPP2R5D mRNA CTD PMID:17997037 NCBI chr 9:21,767,963...21,797,997
Ensembl chr 9:21,767,688...21,797,996
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO Nicotine results in decreased expression of PPP3R1 mRNA CTD PMID:21955143 NCBI chr14:95,758,333...95,808,015 JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions
decreases expression
ISO
EXP
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA
Nicotine results in decreased expression of PRDM16 mRNA
CTD PMID:33091441 NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:170,162,275...170,485,804
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRDX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PRDX3 mRNA] CTD PMID:20230807 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300
JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO Nicotine results in decreased expression of PRG4 mRNA CTD PMID:33640489 NCBI chr13:65,037,363...65,054,764
Ensembl chr13:65,037,363...65,054,508
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Nicotine results in increased expression of PRKAA2 mRNA CTD PMID:22265867 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRKAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA] CTD PMID:20230807 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression ISO Nicotine results in increased expression of PRKAR2B mRNA CTD PMID:18247414 NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:54,291,151...54,381,411
JBrowse link
G Prkca protein kinase C, alpha increases activity
increases expression
ISO
EXP
Nicotine results in increased activity of PRKCA protein
Nicotine results in increased expression of PRKCA mRNA
CTD PMID:12421819 PMID:20426880 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
JBrowse link
G Prkcb protein kinase C, beta affects localization ISO Nicotine affects the localization of PRKCB protein CTD PMID:17003101 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Nicotine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Nicotine results in increased expression of PRKCE mRNA CTD PMID:20426880 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288
JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO Nicotine results in decreased expression of PRKCSH mRNA CTD PMID:16949557 NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:28,810,889...28,822,503
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
ISO PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
Nicotine results in increased activity of PRKCZ protein
CTD PMID:17525161 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Nicotine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Prl prolactin increases secretion ISO Nicotine results in increased secretion of PRL protein CTD PMID:12893845 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Nicotine results in decreased expression of PROK1 protein CTD PMID:24368670 NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:197,537,068...197,547,550
JBrowse link
G Prom2 prominin 2 increases expression ISO Nicotine results in increased expression of PROM2 mRNA CTD PMID:23825647 NCBI chr 3:135,200,944...135,215,130
Ensembl chr 3:135,200,944...135,215,077
JBrowse link
G Prox1 prospero homeobox 1 increases expression ISO Nicotine results in increased expression of PROX1 mRNA CTD PMID:23825647 NCBI chr13:104,196,615...104,251,007
Ensembl chr13:104,200,378...104,250,975
JBrowse link
G Prpf38b pre-mRNA processing factor 38B increases expression ISO Nicotine results in increased expression of PRPF38B mRNA CTD PMID:16949557 NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:199,241,313...199,250,338
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 increases splicing ISO Nicotine results in increased splicing of PRPS1 mRNA alternative form CTD PMID:23825647 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:108,920,651...108,942,711
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Nicotine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:54,947,351...54,959,997
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO Nicotine results in increased expression of PRRC2C mRNA CTD PMID:16949557 NCBI chr13:77,537,226...77,606,926
Ensembl chr13:77,537,814...77,607,001
JBrowse link
G Prss1 serine protease 1 decreases expression ISO Nicotine results in decreased expression of PRSS1 mRNA CTD PMID:16949557 NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:71,331,246...71,334,452
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO Nicotine results in decreased expression of PSMB6 mRNA CTD PMID:18247414 NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA] CTD PMID:20230807 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:14,148,090...14,162,390
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 decreases expression ISO Nicotine results in decreased expression of PSMC4 mRNA CTD PMID:17456735 NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:92,476,690...92,485,060
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921
JBrowse link
G Psmg1 proteasome assembly chaperone 1 decreases expression ISO Nicotine results in decreased expression of PSMG1 mRNA CTD PMID:17997037 NCBI chr11:48,745,581...48,755,040
Ensembl chr11:48,745,581...48,755,040
JBrowse link
G Psmg2 proteasome assembly chaperone 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMG2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PSMG2 mRNA] CTD PMID:20230807 NCBI chr18:63,478,620...63,493,193 JBrowse link
G Ptafr platelet-activating factor receptor decreases expression
increases expression
ISO Nicotine results in decreased expression of PTAFR mRNA
Nicotine results in increased expression of PTAFR mRNA
CTD PMID:18247414 PMID:23825647 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression ISO Nicotine results in increased expression of PTBP2 mRNA CTD PMID:16949557 NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:210,497,706...210,558,291
JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO Nicotine results in decreased expression of PTGES mRNA; Nicotine results in decreased expression of PTGES protein CTD PMID:24380835 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases activity
ISO
EXP
[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of PTGS2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2]
Nicotine results in increased expression of PTGS2 mRNA; Nicotine results in increased expression of PTGS2 protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; ferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]
CTD PMID:16254210 PMID:17003101 PMID:17369603 PMID:17456735 PMID:18068289 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of PTK2 protein CTD PMID:30259641 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126
JBrowse link
G Ptx3 pentraxin 3 decreases expression ISO Nicotine results in decreased expression of PTX3 mRNA CTD PMID:18247414 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372
JBrowse link
G Pvalb parvalbumin decreases expression ISO Nicotine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PYCARD mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA]
Nicotine results in increased expression of PYCARD mRNA
CTD PMID:20230807 PMID:39098741 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
JBrowse link
G Qki QKI, KH domain containing RNA binding increases expression ISO Nicotine results in increased expression of QKI mRNA CTD PMID:17997037 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:52,935,382...53,047,337
JBrowse link
G Rab2a RAB2A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAB2 mRNA] CTD PMID:20230807 NCBI chr 5:26,473,424...26,537,441
Ensembl chr 5:26,473,548...26,538,488
JBrowse link
G Rab6a RAB6A, member RAS oncogene family decreases expression ISO Nicotine results in decreased expression of RAB6A mRNA CTD PMID:12588870 NCBI chr 1:164,370,033...164,422,324
Ensembl chr 1:164,369,861...164,417,763
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAB7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185
JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Nicotine results in increased expression of RAC2 mRNA CTD PMID:23825647 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:61,188,727...61,196,867
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression
multiple interactions
ISO Nicotine results in increased expression of RAD50 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD50 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100
JBrowse link
G Raet1e retinoic acid early transcript 1E increases expression ISO Nicotine results in increased expression of RAET1E mRNA CTD PMID:23825647 NCBI chr 1:3,474,487...3,476,431 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
affects localization
increases activity
ISO Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine affects the localization of RAF1 protein
Nicotine results in increased activity of RAF1 protein
CTD PMID:15574422 PMID:16862215 PMID:17459420 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
JBrowse link
G Ramp1 receptor activity modifying protein 1 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP1 protein CTD PMID:19910445 NCBI chr 9:99,213,031...99,263,696 JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP2 protein CTD PMID:19910445 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,688,703...86,691,231
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of RAMP3 mRNA
[Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP3 protein
CTD PMID:19910445 PMID:21955143 NCBI chr14:85,741,314...85,758,813
Ensembl chr14:85,755,211...85,758,818
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 increases expression EXP Nicotine results in increased expression of RAPGEF3 mRNA CTD PMID:11478936 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668
JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression ISO Nicotine results in decreased expression of RARG mRNA CTD PMID:18247414 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:135,246,427...135,268,889
JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:82,557,556...82,671,527
Ensembl chr16:82,557,428...82,672,984
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases phosphorylation
increases expression
decreases expression
ISO 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein]; Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine results in decreased expression of RB1 protein
CTD PMID:15574422 PMID:16011614 PMID:16601104 PMID:16862215 PMID:18448488 More... NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP4 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:146,922,611...146,959,501
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:46,464,389...46,494,244
Ensembl chr13:46,464,389...46,491,238
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]
Nicotine results in increased expression of RBBP6 mRNA
CTD PMID:12588870 PMID:16949557 NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852
JBrowse link
G Rbbp9 RB binding protein 9, serine hydrolase increases expression ISO Nicotine results in increased expression of RBBP9 mRNA CTD PMID:17997037 NCBI chr 3:152,378,426...152,392,370
Ensembl chr 3:152,378,699...152,385,489
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 decreases expression ISO Nicotine results in decreased expression of RBCK1 mRNA CTD PMID:17997037 NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:161,249,390...161,266,032
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 increases expression ISO Nicotine results in increased expression of RBFOX3 protein CTD PMID:20457658 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411
JBrowse link
G Rbm25 RNA binding motif protein 25 increases expression ISO Nicotine results in increased expression of RBM25 mRNA CTD PMID:16949557 NCBI chr 6:108,993,119...109,050,159
Ensembl chr 6:109,002,869...109,050,159
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
affects localization
decreases expression
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Nicotine affects the localization of and results in increased activity of RELA protein; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]
Nicotine affects the localization of RELA protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of RELA mRNA; Nicotine results in decreased expression of RELA protein
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Nicotine results in decreased expression of RELA protein]; Nicotine affects the localization of and results in increased activity of RELA protein
CTD PMID:16254210 PMID:17135361 PMID:18448488 PMID:23810507 PMID:27984197 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Reln reelin decreases expression EXP Nicotine results in decreased expression of RELN mRNA CTD PMID:28555334 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 decreases expression ISO Nicotine results in decreased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:31,903,972...31,908,451
Ensembl chr15:31,903,965...31,908,445
JBrowse link
G Retn resistin decreases expression EXP Nicotine results in decreased expression of RETN mRNA CTD PMID:32512034 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116
JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Nicotine results in decreased expression of RFXAP mRNA CTD PMID:12588870 NCBI chr 2:141,158,214...141,162,397
Ensembl chr 2:141,158,215...141,162,397
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Nicotine results in increased expression of RGS1 mRNA CTD PMID:18247414 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:58,568,844...58,573,187
JBrowse link
G Rgs13 regulator of G-protein signaling 13 decreases expression EXP Nicotine results in decreased expression of RGS13 mRNA CTD PMID:11478936 NCBI chr13:58,472,604...58,505,922
Ensembl chr13:58,472,604...58,505,922
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RGS2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA]
Nicotine results in increased expression of RGS2 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697
JBrowse link
G Rhob ras homolog family member B increases expression ISO Nicotine results in increased expression of RHOB mRNA CTD PMID:17997037 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772
JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA] CTD PMID:31154625 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995
JBrowse link
G Rlbp1 retinaldehyde binding protein 1 increases expression ISO Nicotine results in increased expression of RLBP1 mRNA CTD PMID:17997037 NCBI chr 1:142,718,262...142,731,621
Ensembl chr 1:142,718,262...142,731,621
JBrowse link
G Rlf RLF zinc finger increases expression ISO Nicotine results in increased expression of RLF mRNA CTD PMID:16949557 NCBI chr 5:139,996,782...140,052,419
Ensembl chr 5:139,996,782...140,052,419
JBrowse link
G Rnd3 Rho family GTPase 3 increases splicing ISO Nicotine results in increased splicing of RND3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536
JBrowse link
G Rnf145 ring finger protein 145 decreases expression ISO Nicotine results in decreased expression of RNF145 mRNA CTD PMID:17456735 NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,507,772...29,552,151
JBrowse link
G Rph3a rabphilin 3A increases expression ISO Nicotine results in increased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:41,203,004...41,279,536
Ensembl chr12:41,200,089...41,279,531
JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:54,109,692...54,112,822
Ensembl chr10:54,109,362...54,112,822
JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225
JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO Nicotine results in decreased expression of RPL7A mRNA CTD PMID:18247414 NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791
JBrowse link
G Rps24 ribosomal protein S24 increases splicing ISO Nicotine results in increased splicing of RPS24 mRNA alternative form CTD PMID:23825647 NCBI chr16:95,429...101,146
Ensembl chr16:96,484...101,144
JBrowse link
G Rps25 ribosomal protein s25 increases expression ISO Nicotine results in increased expression of RPS25 mRNA CTD PMID:18247414 NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:53,629,861...53,632,808
Ensembl chr 8:53,629,861...53,632,808
JBrowse link
G Rps27a ribosomal protein S27a multiple interactions
decreases expression
ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr14:107,486,664...107,488,941
Ensembl chr 5:138,465,088...138,466,080
Ensembl chr14:138,465,088...138,466,080
Ensembl chr 5:138,465,088...138,466,080
JBrowse link
G Rps5 ribosomal protein S5 decreases expression ISO Nicotine results in decreased expression of RPS5 mRNA CTD PMID:33640489 NCBI chr 1:82,610,965...82,615,262
Ensembl chr 1:82,610,965...82,615,262
JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation
multiple interactions
ISO Nicotine results in increased phosphorylation of RPS6 protein
Cholesterol inhibits the reaction [Nicotine results in increased phosphorylation of RPS6 protein]
CTD PMID:31629012 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of RPS6KB1 protein; dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]
Nicotine results in increased phosphorylation of RPS6KB1 protein
CTD PMID:30259641 PMID:31926917 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases expression EXP Nicotine results in decreased expression of RPS6KB2 mRNA CTD PMID:11478936 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:210,880,825...210,887,562
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 affects response to substance ISO RPTOR gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of RSAD2 mRNA CTD PMID:37951547 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320
JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:30,112,529...30,197,267
Ensembl chr 1:30,112,114...30,197,938
JBrowse link
G RT1-Bb RT1 class II, locus Bb multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DQB1 mRNA CTD PMID:37951547 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 multiple interactions ISO Nicotine promotes the reaction [nickel chloride results in increased expression of HLA-F mRNA] CTD PMID:37951547 NCBI chr20:3,407,880...3,484,130 JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRA mRNA CTD PMID:37951547 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRB1 mRNA CTD PMID:37951547 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO Nicotine results in decreased expression of RUNX1T1 mRNA CTD PMID:18247414 NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:31,984,855...32,132,855
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases expression
ISO
EXP
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]
Nicotine results in increased expression of RYR2 mRNA; Nicotine results in increased expression of RYR2 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]
CTD PMID:21113126 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Nicotine results in decreased expression of S100A10 mRNA CTD PMID:18247414 NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:181,904,261...181,913,103
JBrowse link
G S100a14 S100 calcium binding protein A14 increases expression ISO Nicotine results in increased expression of S100A14 mRNA CTD PMID:23825647 NCBI chr 2:178,305,976...178,308,004
Ensembl chr 2:178,306,025...178,307,999
JBrowse link
G S100a2 S100 calcium binding protein A2 increases expression ISO Nicotine results in increased expression of S100A2 mRNA CTD PMID:23825647 NCBI chr 2:178,374,659...178,375,903 JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Nicotine results in decreased expression of S100A6 mRNA CTD PMID:33640489 NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Nicotine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Nicotine results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689
JBrowse link
G Sap30l SAP30-like decreases expression ISO Nicotine results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:42,480,201...42,488,139
Ensembl chr10:42,480,201...42,488,139
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO Nicotine results in increased expression of SAR1B mRNA CTD PMID:17997037 NCBI chr10:36,525,365...36,555,009
Ensembl chr10:36,519,384...36,555,005
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Nicotine results in increased expression of SC5D mRNA CTD PMID:17456735 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277
JBrowse link
G Scaf11 SR-related CTD-associated factor 11 increases expression ISO Nicotine results in increased expression of SCAF11 mRNA CTD PMID:16949557 NCBI chr 7:129,450,872...129,503,280
Ensembl chr 7:129,417,955...129,503,280
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of SCARB1 mRNA; Nicotine results in decreased expression of SCARB1 protein
GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]
CTD PMID:30036686 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Nicotine results in increased expression of SCD1 mRNA
Nicotine results in increased expression of SCD mRNA
CTD PMID:17997037 PMID:23825647 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
JBrowse link
G Scg2 secretogranin II increases expression EXP Nicotine results in increased expression of SCG2 mRNA CTD PMID:1907749 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Nicotine results in increased expression of SDC4 mRNA CTD PMID:21955143 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670
JBrowse link
G Sec61g Sec61 translocon subunit gamma increases expression ISO Nicotine results in increased expression of SEC61G mRNA CTD PMID:16949557 NCBI chr14:95,113,083...95,119,458
Ensembl chr 9:48,798,504...48,798,710
Ensembl chr14:48,798,504...48,798,710
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SENP6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:89,868,115...89,951,803
Ensembl chr 8:89,868,867...89,948,062
JBrowse link
G Septin7 septin 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:31,995,005...32,059,072
JBrowse link
G Septin8 septin 8 decreases expression ISO Nicotine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504
JBrowse link
G Serinc3 serine incorporator 3 increases expression ISO Nicotine results in increased expression of SERINC3 mRNA CTD PMID:16949557 NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:172,721,321...172,740,765
JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Nicotine results in increased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166
JBrowse link
G Serpine1 serpin family E member 1 increases secretion
increases expression
EXP
ISO
Nicotine results in increased secretion of SERPINE1 protein
Nicotine results in increased expression of SERPINE1 mRNA
CTD PMID:11166759 PMID:21596853 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Nicotine results in decreased expression of SERPINF1 mRNA
Nicotine results in decreased expression of SERPINF1 mRNA; Nicotine results in decreased expression of SERPINF1 protein
CTD PMID:21955143 PMID:26536586 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression ISO Nicotine results in decreased expression of SERPINH1 mRNA CTD PMID:16949557 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976
JBrowse link
G Sertad4 SERTA domain containing 4 decreases expression ISO Nicotine results in decreased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:106,889,019...106,899,777
Ensembl chr13:106,889,019...106,900,309
JBrowse link
G Sf3b6 splicing factor 3B, subunit 6 increases expression ISO Nicotine results in increased expression of SF3B6 mRNA CTD PMID:16949557 NCBI chr 6:33,545,495...33,554,537
Ensembl chr 6:33,545,512...33,554,608
JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Nicotine results in increased expression of SFPQ mRNA
CTD PMID:17997037 PMID:20230807 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926
JBrowse link
G Sftpa1 surfactant protein A1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPA1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]
CTD PMID:9458815 NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,042,255...17,045,769
JBrowse link
G Sftpc surfactant protein C increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPC mRNA
[Nicotine co-treated with Quartz] results in increased expression of SFTPC protein; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]
CTD PMID:9458815 PMID:36868510 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Nicotine results in increased expression of SGK1 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Nicotine results in decreased expression of SGPP1 mRNA CTD PMID:17997037 NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:100,161,024...100,182,259
JBrowse link
G Sh2d2a SH2 domain containing 2A increases expression ISO Nicotine results in increased expression of SH2D2A mRNA CTD PMID:23825647 NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:175,609,874...175,616,685
JBrowse link
G Sh3d19 SH3 domain containing 19 increases splicing ISO Nicotine results in increased splicing of SH3D19 mRNA alternative form CTD PMID:23825647 NCBI chr 2:173,654,234...173,814,030
Ensembl chr 2:173,654,420...173,814,025
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Nicotine results in increased expression of SH3KBP1 mRNA CTD PMID:23825647 NCBI chr  X:38,686,530...39,031,658
Ensembl chr  X:38,686,530...39,031,393
JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO Nicotine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:153,524,324...153,537,571
Ensembl chr 2:153,527,571...153,537,161
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 protein; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of CXCL8 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]
resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA]
CTD PMID:22687363 PMID:23199342 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression ISO Nicotine results in decreased expression of SIVA1 mRNA CTD PMID:16949557 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790
JBrowse link
G Slbp stem-loop histone mRNA binding protein multiple interactions
decreases expression
ISO 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; Roscovitine inhibits the reaction [Nicotine results in decreased expression of SLBP protein]
Nicotine results in decreased expression of SLBP mRNA; Nicotine results in decreased expression of SLBP protein
CTD PMID:35929799 NCBI chr14:81,295,479...81,306,446
Ensembl chr14:81,296,223...81,306,447
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO
EXP
Nicotine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 PMID:28555334 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498
JBrowse link
G Slc18a3 solute carrier family 18 member A3 multiple interactions EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of SLC18A3 protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of SLC18A3 protein] CTD PMID:20361958 PMID:22119111 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Nicotine results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of SLC1A1 protein
Tetradecanoylphorbol Acetate inhibits the reaction [Nicotine results in decreased activity of SLC1A1 protein]
CTD PMID:24355585 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression
multiple interactions
ISO
EXP
nicotine decreases expression of Slc1a2 mRNA and protein in striatum
[nicotine cotreated with sucrose] decreases expression of Slc1a2 protein in nucleus accumbens
RGD PMID:33242460 PMID:29753887 RGD:598154614, RGD:616363027 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
affects response to substance
ISO Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
SLC22A2 gene SNP affects the susceptibility to Nicotine
CTD PMID:23770354 PMID:25143296 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc25a48 solute carrier family 25, member 48 decreases expression ISO Nicotine results in decreased expression of SLC25A48 mRNA CTD PMID:23825647 NCBI chr17:8,113,134...8,172,376
Ensembl chr17:8,127,111...8,166,042
JBrowse link
G Slc35a1 solute carrier family 35 member A1 increases expression ISO Nicotine results in increased expression of SLC35A1 mRNA CTD PMID:16949557 NCBI chr 5:54,021,896...54,044,677
Ensembl chr 5:54,021,896...54,044,677
JBrowse link
G Slc37a2 solute carrier family 37 member 2 increases expression ISO Nicotine results in increased expression of SLC37A2 mRNA CTD PMID:23825647 NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:45,134,596...45,277,989
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO Nicotine results in increased expression of SLC39A6 mRNA CTD PMID:16949557 NCBI chr18:16,139,621...16,160,163
Ensembl chr18:16,135,008...16,160,163
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Nicotine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions EXP Nicotine affects the reaction [Hemicholinium 3 binds to SLC5A7 protein] CTD PMID:21633116 NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,922,697...7,953,509
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases methylation
decreases activity
ISO
EXP
Nicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]
Nicotine results in decreased expression of SLC6A3 mRNA; Nicotine results in decreased expression of SLC6A3 protein
Nicotine results in increased methylation of SLC6A3 promoter
Nicotine results in decreased activity of SLC6A3 protein
Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]; Mecamylamine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]
CTD PMID:17227438 PMID:23999947 PMID:31945395 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Nicotine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:56,718,849...56,737,702
Ensembl chr18:56,718,849...56,737,702
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO nicotine decreases expression of Slc7a11 mRNA and protein in striatum and hippocampus RGD PMID:33242460 RGD:598154614 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Nicotine results in increased expression of SLC7A5 mRNA CTD PMID:23825647 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 increases expression ISO Nicotine results in increased expression of SLCO2A1 mRNA CTD PMID:23825647 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921
JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957
JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Nicotine results in decreased expression of SMAD2 mRNA; Nicotine results in decreased expression of SMAD2 protein CTD PMID:29660438 PMID:31299270 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Nicotine results in decreased expression of SMAD3 mRNA
Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein
CTD PMID:20230807 PMID:22691361 PMID:29660438 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324
JBrowse link
G Smad9 SMAD family member 9 increases expression ISO Nicotine results in increased expression of SMAD9 mRNA CTD PMID:18247414 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMPD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936
JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions
increases response to substance
ISO
EXP
Nicotine results in increased expression of SNAI1 mRNA; Nicotine results in increased expression of SNAI1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
SNAI1 results in increased susceptibility to Nicotine
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:23219715 PMID:34245815 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of SNAI2 mRNA
Nicotine results in decreased expression of SNAI2 mRNA
CTD PMID:20339300 PMID:23219715 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349
JBrowse link
G Snapc3 small nuclear RNA activating complex, polypeptide 3 increases expression ISO Nicotine results in increased expression of SNAPC3 mRNA CTD PMID:16949557 NCBI chr 5:102,863,867...102,890,573
Ensembl chr 5:102,863,854...102,893,499
JBrowse link
G Snca synuclein alpha increases expression ISO Nicotine results in increased expression of SNCA mRNA CTD PMID:18247414 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Sncg synuclein, gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SNCG mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCG mRNA] CTD PMID:20230807 NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,706,753...9,712,076
JBrowse link
G Snord8 small nucleolar RNA, C/D box 8 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of SNORD8 mRNA CTD PMID:28065790 NCBI chr15:27,391,331...27,391,440
Ensembl chr15:27,391,331...27,391,440
JBrowse link
G Snrk SNF related kinase decreases expression ISO Nicotine results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:130,657,204...130,711,461
Ensembl chr 8:130,657,266...130,711,457
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Nicotine results in increased expression of SOCS3 mRNA CTD PMID:29155039 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SOD1 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein
CTD PMID:16627626 PMID:29617909 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in decreased expression of SOD2 protein
SOD2 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of SOD2 protein]
Nicotine results in increased expression of SOD2 protein
CTD PMID:18343235 PMID:22687363 PMID:28681937 PMID:29617909 PMID:29747151 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] CTD PMID:16949557 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350
JBrowse link
G Sost sclerostin increases expression ISO Nicotine results in increased expression of SOST mRNA CTD PMID:33640489 NCBI chr10:87,412,722...87,415,766
Ensembl chr10:87,411,721...87,415,766
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A decreases expression ISO Nicotine results in decreased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:38,142,633...38,146,199
Ensembl chr10:38,144,782...38,147,171
JBrowse link
G Sox18 SRY-box transcription factor 18 decreases expression ISO Nicotine results in decreased expression of SOX18 mRNA CTD PMID:17456735 NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:189,163,002...189,164,802
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Nicotine results in decreased expression of SOX9 mRNA; Nicotine results in decreased expression of SOX9 protein CTD PMID:29660438 PMID:31299270 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein] CTD PMID:24089524 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513
JBrowse link
G Spag9 sperm associated antigen 9 increases expression ISO Nicotine results in increased expression of SPAG9 mRNA CTD PMID:16949557 NCBI chr10:79,440,311...79,574,709
Ensembl chr10:79,440,377...79,575,258
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SPP1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]
CTD PMID:11425648 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Sprr2d small proline-rich protein 2D increases expression ISO Nicotine results in increased expression of SPRR2D mRNA CTD PMID:23825647 NCBI chr 2:180,565,685...180,566,282
Ensembl chr 2:180,566,007...180,567,002
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 increases expression ISO Nicotine results in increased expression of SPTLC3 mRNA CTD PMID:23825647 NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:147,301,801...147,434,044
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]
Nicotine results in increased expression of SQSTM1 protein
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]
CTD PMID:31926917 PMID:33010382 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein]; Nicotine results in increased phosphorylation of and results in increased activity of SRC protein; RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] CTD PMID:14569062 PMID:16862215 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SREBF1 mRNA
Nicotine results in increased expression of SREBF1 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA
CTD PMID:18247414 PMID:29155039 PMID:29617909 PMID:31622651 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO Nicotine results in decreased expression of SRGAP2 mRNA CTD PMID:17997037 NCBI chr13:45,298,192...45,519,330
Ensembl chr13:45,298,192...45,519,330
JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:96,364,253...96,372,393
Ensembl chr13:96,364,298...96,373,257
JBrowse link
G Srpx2 sushi-repeat-containing protein, X-linked 2 increases expression ISO Nicotine results in increased expression of SRPX2 mRNA CTD PMID:23825647 NCBI chr  X:101,399,748...101,425,486
Ensembl chr  X:101,399,853...101,425,484
JBrowse link
G Sst somatostatin decreases expression ISO Nicotine results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 decreases expression ISO Nicotine results in decreased expression of ST8SIA3 mRNA CTD PMID:21955143 NCBI chr18:60,024,555...60,031,050
Ensembl chr18:60,024,236...60,032,473
JBrowse link
G Stac SH3 and cysteine rich domain increases expression ISO Nicotine results in increased expression of STAC mRNA CTD PMID:23825647 NCBI chr 8:120,409,165...120,531,394
Ensembl chr 8:120,409,165...120,531,320
JBrowse link
G Star steroidogenic acute regulatory protein increases methylation
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased methylation of STAR promoter
LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
Taurine inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Taurine inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Nicotine results in decreased expression of STAR; Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]
CTD PMID:20498001 PMID:21971485 PMID:22265867 PMID:24709674 PMID:31846720 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA] CTD PMID:31154625 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO Nicotine results in decreased expression of STAT2 mRNA CTD PMID:18247414 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:1,287,024...1,303,459
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
affects expression
increases response to substance
increases activity
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Cisplatin results in decreased activity of STAT3 protein]; Nicotine inhibits the reaction [Paclitaxel results in decreased activity of STAT3 protein]; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; Nicotine results in increased phosphorylation of and results in increased activity of STAT3 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; U 0126 inhibits the reaction [Nicotine results in increased activity of STAT3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form; Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]
Nicotine affects the expression of STAT3 mRNA
STAT3 protein results in increased susceptibility to Nicotine
HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Quartz results in decreased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased phosphorylation of STAT3 protein]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
STAT3 results in increased susceptibility to Nicotine
CTD PMID:18448488 PMID:20106947 PMID:20943775 PMID:21606497 PMID:24095726 More... NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation
ISO Cholesterol inhibits the reaction [Nicotine results in decreased phosphorylation of STAT5 protein] CTD PMID:31629012 PMID:31783125 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression ISO Nicotine results in increased expression of STAT5B mRNA CTD PMID:18805435 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO Nicotine results in increased expression of STAT6 mRNA CTD PMID:18805435 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Nicotine results in increased expression of STC2 mRNA CTD PMID:16949557 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447
JBrowse link
G Steap1 STEAP family member 1 increases expression ISO Nicotine results in increased expression of STEAP1 mRNA CTD PMID:23825647 NCBI chr 4:29,231,809...29,242,317
Ensembl chr 4:29,231,753...29,242,317
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of STIP1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STIP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654
JBrowse link
G Stk25 serine/threonine kinase 25 increases expression ISO Nicotine results in increased expression of STK25 mRNA CTD PMID:18247414 NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:101,609,221...101,621,359
JBrowse link
G Strip2 striatin interacting protein 2 decreases expression ISO Nicotine results in decreased expression of STRIP2 mRNA CTD PMID:21955143 NCBI chr 4:59,503,478...59,545,745
Ensembl chr 4:59,503,481...59,545,739
JBrowse link
G Stx4 syntaxin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STX4A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STX4A mRNA] CTD PMID:20230807 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774
JBrowse link
G Stxbp3 syntaxin binding protein 3 increases expression ISO Nicotine results in increased expression of STXBP3 mRNA CTD PMID:16949557 NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:199,130,725...199,173,823
JBrowse link
G Sub1 SUB1 regulator of transcription increases expression ISO Nicotine results in increased expression of SUB1 mRNA CTD PMID:17456735 NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:62,732,736...62,747,679
JBrowse link
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit decreases expression ISO Nicotine results in decreased expression of SUPT4H1 mRNA CTD PMID:18247414 NCBI chr10:73,036,560...73,042,821
Ensembl chr10:73,036,343...73,043,088
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO Nicotine results in decreased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721
JBrowse link
G Syngr2 synaptogyrin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SYNGR2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SYNGR2 mRNA] CTD PMID:20230807 NCBI chr10:103,528,599...103,533,167
Ensembl chr10:103,528,607...103,533,162
JBrowse link
G Synpo synaptopodin increases expression ISO Nicotine results in increased expression of SYNPO mRNA CTD PMID:23825647 NCBI chr18:56,326,369...56,347,359
Ensembl chr18:56,319,571...56,353,306
JBrowse link
G Syt3 synaptotagmin 3 increases methylation EXP Nicotine results in increased methylation of SYT3 gene CTD PMID:32994467 NCBI chr 1:104,017,341...104,032,046
Ensembl chr 1:104,017,379...104,032,045
JBrowse link
G Syt4 synaptotagmin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SYT4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SYT4 mRNA] CTD PMID:20230807 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Nicotine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:170,687,606...170,881,375
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases methylation EXP Nicotine results in decreased methylation of TAB1 gene CTD PMID:35026373 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:113,555,819...113,587,351
JBrowse link
G Tacr1 tachykinin receptor 1 decreases expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of TACR1 mRNA; Nicotine results in decreased expression of TACR1 protein
Nicotine results in increased expression of TACR1 mRNA; Nicotine results in increased expression of TACR1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]
CTD PMID:26524655 PMID:27329243 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492
JBrowse link
G Tada2b transcriptional adaptor 2B increases expression EXP Nicotine results in increased expression of TADA2B mRNA CTD PMID:27782041 NCBI chr14:78,503,939...78,523,715
Ensembl chr14:78,503,644...78,515,436
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Nicotine results in decreased expression of TAGLN2 mRNA CTD PMID:16949557 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330
JBrowse link
G Taok1 TAO kinase 1 increases expression ISO Nicotine results in increased expression of TAOK1 mRNA CTD PMID:16949557 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,871,198...62,957,595
JBrowse link
G Tbxa2r thromboxane A2 receptor increases activity EXP Nicotine results in increased activity of TBXA2R protein CTD PMID:21316381 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases splicing ISO Nicotine results in increased splicing of TENT4A mRNA alternative form CTD PMID:23825647 NCBI chr 1:35,594,380...35,627,836
Ensembl chr 1:35,594,380...35,627,836
JBrowse link
G Tex264 testis expressed 264, ER-phagy receptor decreases expression ISO Nicotine results in decreased expression of TEX264 mRNA CTD PMID:17997037 NCBI chr 8:116,174,517...116,201,578
Ensembl chr 8:116,174,518...116,201,667
JBrowse link
G Tf transferrin multiple interactions ISO [Nicotine co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein CTD PMID:36372912 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tfdp1 transcription factor Dp-1 multiple interactions
increases expression
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein]
Nicotine results in increased expression of TFDP1 mRNA
Nicotine results in decreased expression of TFDP1 mRNA
CTD PMID:17997037 PMID:18247414 PMID:20061081 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]
Nicotine results in increased expression of TFPI2 mRNA
CTD PMID:12588870 NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426
JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions
ISO Nicotine results in increased expression of TFRC mRNA
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]
CTD PMID:16949557 PMID:20230807 PMID:28065790 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
increases expression
affects expression
ISO
EXP
Nicotine results in decreased expression of TGFB1 mRNA
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Nicotine results in increased expression of TGFB1 mRNA
Nicotine affects the expression of TGFB1 mRNA
Nicotine results in decreased expression of TGFB1 mRNA; Nicotine results in decreased expression of TGFB1 protein
Nicotine results in increased expression of TGFB1 protein
CTD PMID:21237301 PMID:22691361 PMID:25280790 PMID:29660438 PMID:31299270 More... NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Nicotine results in decreased expression of TGFBR1 mRNA; Nicotine results in decreased expression of TGFBR1 protein CTD PMID:29660438 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression EXP Nicotine results in decreased expression of TGFBR2 mRNA CTD PMID:28555334 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of TH mRNA; Nicotine results in increased expression of TH protein
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; conotoxin AuIB inhibits the reaction [Nicotine results in increased expression of TH mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of TH mRNA]; ZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; ZM 241385 inhibits the reaction [Nicotine results in increased expression of TH mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TH mRNA; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
CTD PMID:17498763 PMID:19594327 PMID:20230807 PMID:23933227 PMID:28082123 More... NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Thoc1 THO complex subunit 1 increases expression ISO Nicotine results in increased expression of THOC1 mRNA CTD PMID:16949557 NCBI chr18:1,253,041...1,291,956
Ensembl chr18:1,256,637...1,292,630
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression
increases expression
multiple interactions
ISO
EXP
Nicotine affects the expression of TIMP1 mRNA
Nicotine results in increased expression of TIMP1 mRNA
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP1 mRNA
CTD PMID:18986645 PMID:34153408 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Nicotine results in increased expression of TIMP2 mRNA CTD PMID:34153408 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects expression
multiple interactions
ISO Nicotine affects the expression of TIMP3 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA
CTD PMID:18986645 PMID:20230807 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 multiple interactions
decreases expression
affects expression
ISO
EXP
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP4 mRNA
Nicotine results in decreased expression of TIMP4 protein
Nicotine affects the expression of TIMP4 mRNA
CTD PMID:18986645 PMID:28681937 NCBI chr 4:149,978,667...149,985,350
Ensembl chr 4:149,978,685...149,985,452
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression ISO Nicotine results in increased expression of TINAGL1 mRNA CTD PMID:23825647 NCBI chr 5:147,797,884...147,807,925
Ensembl chr 5:147,797,892...147,807,871
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Nicotine results in increased expression of TIPARP mRNA CTD PMID:17456735 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406
JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA] CTD PMID:20230807 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD PMID:18844224 PMID:20722969 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA]
[Aerosols co-treated with Nicotine] results in increased expression of TLR4 mRNA
CTD PMID:27984197 PMID:33469865 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO Nicotine results in increased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:30,781,452...31,058,888
Ensembl chr 7:30,897,991...31,058,889
JBrowse link
G Tmem125 transmembrane protein 125 increases expression ISO Nicotine results in increased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:137,348,545...137,349,949
Ensembl chr 5:137,345,202...137,351,952
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Nicotine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:41,520,595...41,693,938
Ensembl chr13:41,520,359...41,693,938
JBrowse link
G Tmem222 transmembrane protein 222 increases splicing ISO Nicotine results in increased splicing of TMEM222 mRNA alternative form CTD PMID:23825647 NCBI chr 5:150,749,746...150,763,031
Ensembl chr 5:150,749,748...150,767,278
JBrowse link
G Tmem41b transmembrane protein 41B increases expression ISO Nicotine results in increased expression of TMEM41B mRNA CTD PMID:16949557 NCBI chr 1:173,447,362...173,461,760
Ensembl chr 1:173,447,367...173,461,597
JBrowse link
G Tmem63a transmembrane protein 63a increases expression ISO Nicotine results in increased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:95,194,323...95,227,944
Ensembl chr13:95,195,234...95,228,302
JBrowse link
G Tmem97 transmembrane protein 97 increases expression ISO Nicotine results in increased expression of TMEM97 mRNA CTD PMID:17997037 NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,936,271...63,945,818
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
increases secretion
decreases expression
increases expression
increases degradation
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
Nicotine affects the expression of TNF mRNA
Nicotine results in increased secretion of TNF protein
Nicotine results in decreased expression of TNF protein
Nicotine results in increased expression of TNF mRNA; Nicotine results in increased expression of TNF protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; erdosteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TNF mRNA]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Nicotine results in increased expression of TNF protein]
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:15135227 PMID:16254210 PMID:17216608 PMID:20426880 PMID:21237301 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions
EXP Nicotine results in increased expression of TNFRSF11B mRNA
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]
CTD PMID:29981921 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression
decreases expression
EXP
ISO
Nicotine results in increased expression of TNFRSF1A mRNA
Nicotine results in decreased expression of TNFRSF1A mRNA
CTD PMID:18247414 PMID:20426880 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of TNFSF11 mRNA
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA]
CTD PMID:29981921 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TNK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNK2 mRNA] CTD PMID:20230807 NCBI chr11:81,619,795...81,659,074
Ensembl chr11:81,619,796...81,659,074
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 increases expression ISO Nicotine results in increased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:56,847,837...56,886,302
Ensembl chr11:56,846,334...56,886,320
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 increases expression ISO Nicotine results in increased expression of TOPBP1 mRNA CTD PMID:16949557 NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:112,766,508...112,810,540
JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions
affects response to substance
affects expression
ISO
EXP
Nicotine results in decreased expression of TP53 mRNA; Nicotine results in decreased expression of TP53 protein
Nicotine results in increased expression of TRP53 mRNA; Nicotine results in increased expression of TRP53 protein
Nicotine results in decreased expression of TRP53 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA]
Nicotine results in increased expression of TP53 mRNA
TP53 protein affects the susceptibility to Nicotine
Nicotine affects the expression of TP53 mRNA
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of TP53 protein]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
Nicotine results in increased expression of TP53 protein
CTD PMID:10837795 PMID:15983034 PMID:16011614 PMID:16601104 PMID:18247414 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Nicotine] results in increased expression of TRP53INP1 mRNA CTD PMID:20230807 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA] CTD PMID:20230807 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639
JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPP2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPP2 mRNA] CTD PMID:20230807 NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:53,538,313...53,620,251
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Nicotine results in increased expression of TPR mRNA CTD PMID:16949557 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602
JBrowse link
G Tra2a transformer 2 alpha increases expression ISO Nicotine results in increased expression of TRA2A mRNA CTD PMID:16949557 NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:79,551,542...79,570,619
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 increases expression ISO Nicotine results in increased expression of TREM1 mRNA CTD PMID:23825647 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892
JBrowse link
G Trib2 tribbles pseudokinase 2 increases expression ISO Nicotine results in increased expression of TRIB2 mRNA CTD PMID:16949557 NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:44,274,762...44,299,094
JBrowse link
G Trim28 tripartite motif-containing 28 increases splicing ISO Nicotine results in increased splicing of TRIM28 mRNA alternative form CTD PMID:23825647 NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572
JBrowse link
G Trip11 thyroid hormone receptor interactor 11 increases expression ISO Nicotine results in increased expression of TRIP11 mRNA CTD PMID:16949557 NCBI chr 6:126,760,263...126,832,619
Ensembl chr 6:126,760,265...126,832,570
JBrowse link
G Trnp1 TMF1-regulated nuclear protein 1 increases expression ISO Nicotine results in increased expression of TRNP1 mRNA CTD PMID:23825647 NCBI chr 5:150,990,312...150,997,148
Ensembl chr 5:150,989,973...150,997,277
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects response to substance
increases expression
increases activity
EXP Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]
TRPV1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of TRPV1 mRNA; Nicotine results in increased expression of TRPV1 protein
Nicotine results in increased activity of TRPV1 protein
CTD PMID:19483072 PMID:26524655 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TSC22D1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TSC22D1 mRNA] CTD PMID:20230807 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322
JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression ISO Nicotine results in increased expression of TSHR mRNA CTD PMID:18247414 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Nicotine results in decreased expression of TUBA4A mRNA CTD PMID:16949557 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Nicotine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:2,004,836...2,012,281
Ensembl chr 9:2,004,840...2,012,286
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Nicotine results in decreased expression of TUBB mRNA CTD PMID:16949557 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression ISO Nicotine results in increased expression of TUT4 mRNA CTD PMID:16949557 NCBI chr 5:128,354,975...128,535,288
Ensembl chr 5:128,431,719...128,535,656
JBrowse link
G Twf2 twinfilin actin-binding protein 2 decreases expression ISO Nicotine results in decreased expression of TWF2 mRNA CTD PMID:17997037 NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:115,723,970...115,737,025
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of TWIST1 mRNA
Nicotine promotes the reaction [Quartz results in increased expression of TWIST1 protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of TWIST1 protein]
CTD PMID:23219715 PMID:36868510 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965
JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of TXN1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TXN1 protein]
CTD PMID:28082123 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO Nicotine results in increased expression of TXNDC9 mRNA CTD PMID:16949557 NCBI chr 9:47,707,628...47,717,761
Ensembl chr 9:47,707,231...47,880,085
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Nicotine results in increased expression of TXNIP mRNA CTD PMID:17456735 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases expression ISO Nicotine results in increased expression of U2SURP mRNA CTD PMID:16949557 NCBI chr 8:104,898,580...104,963,642
Ensembl chr 8:104,898,425...104,955,422
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of UBA2 protein
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901
JBrowse link
G Ubb ubiquitin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA] CTD PMID:20230807 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,727,701...47,750,335
JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA] CTD PMID:20230807 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of UBE2C mRNA
Nicotine results in decreased expression of UBE2C mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
CTD PMID:16949557 PMID:23825647 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UBE2D2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBE2D2 mRNA] CTD PMID:20230807 NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,638,527...27,683,074
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Nicotine results in decreased expression of UBE2I mRNA CTD PMID:18247414 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866
JBrowse link
G Ube3a ubiquitin protein ligase E3A multiple interactions
decreases expression
ISO Mecamylamine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]; Nicotine inhibits the reaction [alpha-cobratoxin results in decreased expression of UBE3A mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] CTD PMID:12588870 NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA] CTD PMID:20230807 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417
JBrowse link
G Ucp1 uncoupling protein 1 decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of UCP1 mRNA; Nicotine results in decreased expression of UCP1 protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein
CTD PMID:33091441 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420
JBrowse link
G Ufm1 ubiquitin-fold modifier 1 increases expression ISO Nicotine results in increased expression of UFM1 mRNA CTD PMID:16949557 NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:140,119,725...140,127,866
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO Nicotine results in increased expression of UGP2 mRNA CTD PMID:18247414 NCBI chr14:99,657,637...99,698,573
Ensembl chr14:99,657,639...99,698,002
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
decreases expression
ISO UGT1A4 protein results in increased glucuronidation of Nicotine
Nicotine results in decreased expression of UGT1A5 mRNA
CTD PMID:14570768 PMID:16141602 PMID:21955143 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 PMID:16141602 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Unc119 unc-119 lipid binding chaperone decreases expression ISO Nicotine results in decreased expression of UNC119 mRNA CTD PMID:16949557 NCBI chr10:63,735,927...63,741,404
Ensembl chr10:63,735,777...63,741,404
JBrowse link
G Unc45b unc-45 myosin chaperone B decreases expression EXP Nicotine results in decreased expression of UNC45B mRNA CTD PMID:27782041 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980
JBrowse link
G Unc5b unc-5 netrin receptor B increases expression ISO Nicotine results in increased expression of UNC5B mRNA CTD PMID:23825647 NCBI chr20:29,240,639...29,307,270
Ensembl chr20:29,240,650...29,307,270
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Nicotine results in increased expression of UPP1 mRNA CTD PMID:23825647 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:88,023,351...88,043,034
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP Nicotine results in decreased expression of UQCRC2 protein CTD PMID:28681937 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression ISO Nicotine results in decreased expression of UQCRFS1 mRNA CTD PMID:18247414 NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950
JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Nicotine results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:99,783,157...99,845,787
Ensembl chr 1:99,783,158...99,853,906
JBrowse link
G Uros uroporphyrinogen III synthase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UROS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UROS mRNA] CTD PMID:20230807 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:197,921,701...197,936,150
JBrowse link
G Vamp4 vesicle-associated membrane protein 4 increases expression ISO Nicotine results in increased expression of VAMP4 mRNA CTD PMID:17997037 NCBI chr13:77,453,135...77,475,909
Ensembl chr13:77,453,121...77,476,024
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of VCAM1 mRNA CTD PMID:11166759 PMID:16254210 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vcan versican increases expression ISO Nicotine results in increased expression of VCAN mRNA CTD PMID:23825647 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression
multiple interactions
increases secretion
affects response to substance
decreases secretion
ISO
EXP
Nicotine results in increased expression of VEGFA mRNA; Nicotine results in increased expression of VEGFA protein
Nicotine results in decreased expression of VEGFA protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
Nicotine results in increased secretion of VEGFA protein
Nicotine affects the susceptibility to VEGFA
Nicotine results in decreased secretion of VEGFA protein
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]
CTD PMID:14569062 PMID:16499655 PMID:20426880 PMID:20457658 PMID:21378373 More... NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of VIM mRNA
Nicotine promotes the reaction [Quartz results in increased expression of VIM protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of VIM protein]
Nicotine results in increased expression of VIM mRNA; Nicotine results in increased expression of VIM protein
CTD PMID:18247414 PMID:18844224 PMID:23219715 PMID:36868510 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Vps28 VPS28 subunit of ESCRT-I multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS28 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of VPS28 mRNA] CTD PMID:20230807 NCBI chr 7:110,222,638...110,226,486
Ensembl chr 7:110,222,638...110,225,569
JBrowse link
G Vps41 VPS41 subunit of HOPS complex multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS41 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of VPS41 mRNA] CTD PMID:20230807 NCBI chr17:50,758,732...50,923,129
Ensembl chr17:50,758,734...50,923,133
JBrowse link
G Vrk2 VRK serine/threonine kinase 2 decreases expression ISO Nicotine results in decreased expression of VRK2 mRNA CTD PMID:23825647 NCBI chr14:104,514,815...104,635,549
Ensembl chr14:104,514,100...104,720,933
JBrowse link
G Vwf von Willebrand factor increases expression
decreases expression
ISO Nicotine results in increased expression of VWF mRNA
Nicotine results in decreased expression of VWF mRNA
CTD PMID:11166759 PMID:17456735 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757
JBrowse link
G Wbp4 WW domain binding protein 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of WBP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of WBP4 mRNA] CTD PMID:20230807 NCBI chr15:61,271,774...61,299,740
Ensembl chr15:61,271,783...61,299,740
JBrowse link
G Wnt4 Wnt family member 4 increases expression
multiple interactions
ISO Nicotine results in increased expression of WNT4 mRNA; Nicotine results in increased expression of WNT4 protein
Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 protein]
CTD PMID:33640489 PMID:35411647 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128
JBrowse link
G Wnt7b Wnt family member 7B increases expression ISO Nicotine results in increased expression of WNT7B mRNA CTD PMID:23825647 NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:118,514,684...118,559,316
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of XAF1 mRNA CTD PMID:37951547 NCBI chr10:57,415,935...57,428,348
Ensembl chr10:57,415,658...57,428,349
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:18477628 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of XDH protein] CTD PMID:31857090 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
increases expression
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of XIAP protein; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]
Nicotine results in increased expression of XIAP mRNA; Nicotine results in increased expression of XIAP protein
CTD PMID:16601104 PMID:18676776 PMID:20727180 PMID:21267677 PMID:30259641 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978
JBrowse link
G Xist X inactive specific transcript increases expression ISO Nicotine results in increased expression of XIST mRNA CTD PMID:16949557 NCBI chr  X:72,540,753...72,558,266 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO XRCC1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase increases expression ISO Nicotine results in increased expression of YES1 mRNA CTD PMID:16949557 NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:120,646,838...120,746,441
JBrowse link
G Yipf4 Yip1 domain family, member 4 decreases expression ISO Nicotine results in decreased expression of YIPF4 mRNA CTD PMID:17997037 NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:26,682,488...26,714,066
JBrowse link
G Zc3h7a zinc finger CCCH type containing 7 A increases splicing ISO Nicotine results in increased splicing of ZC3H7A mRNA alternative form CTD PMID:23825647 NCBI chr10:4,980,147...5,019,637
Ensembl chr10:4,980,161...5,019,636
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Nicotine results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:63,787,292...63,968,960
Ensembl chr 5:63,788,217...63,968,549
JBrowse link
G Zcchc9 zinc finger CCHC-type containing 9 increases expression ISO Nicotine results in increased expression of ZCCHC9 mRNA CTD PMID:16949557 NCBI chr 2:24,773,319...24,783,339
Ensembl chr 2:24,773,319...24,781,999
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Nicotine results in increased expression of ZEB1 mRNA CTD PMID:16949557 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745
JBrowse link
G Zfp146 zinc finger protein 146 increases expression ISO Nicotine results in increased expression of ZNF146 mRNA CTD PMID:16949557 NCBI chr 1:94,537,054...94,549,315
Ensembl chr 1:94,536,083...94,551,860
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases response to substance
increases expression
increases activity
ISO [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA; [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein; Bungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
ZFP36 protein results in increased susceptibility to Nicotine
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; tin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]
Nicotine results in increased expression of ZFP36 mRNA; Nicotine results in increased expression of ZFP36 protein
Nicotine results in increased activity of ZFP36 promoter
CTD PMID:21606497 PMID:22093924 PMID:24095726 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108
JBrowse link
G Zfp42 zinc finger protein 42 multiple interactions
increases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] CTD PMID:15749260 NCBI chr16:55,568,903...55,577,883
Ensembl chr16:55,568,093...55,578,170
Ensembl chr 4:55,568,093...55,578,170
JBrowse link
G Zfp605 zinc finger protein 605 increases expression ISO Nicotine results in increased expression of ZNF605 mRNA CTD PMID:16949557 NCBI chr12:52,202,487...52,234,782
Ensembl chr12:52,205,132...52,234,512
JBrowse link
G Zfr zinc finger RNA binding protein multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] CTD PMID:12588870 NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:62,864,338...62,929,133
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Nicotine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:100,785,282...100,797,716
Ensembl chr 8:100,787,789...100,792,427
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 increases expression ISO Nicotine results in increased expression of ZMYND8 mRNA CTD PMID:16949557 NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:174,948,537...175,061,571
JBrowse link
G Znrf1 zinc and ring finger 1 decreases expression ISO Nicotine results in decreased expression of ZNRF1 mRNA CTD PMID:17997037 NCBI chr19:56,403,816...56,490,901
Ensembl chr19:56,405,728...56,490,881
JBrowse link
O-propanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases abundance
multiple interactions
ISO APP protein mutant form results in increased abundance of propionylcarnitine
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of propionylcarnitine]
[APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in decreased abundance of propionylcarnitine
CTD PMID:39172838 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Mapt microtubule-associated protein tau decreases abundance
multiple interactions
ISO MAPT protein mutant form results in decreased abundance of propionylcarnitine
PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of propionylcarnitine]
CTD PMID:39172838 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in decreased abundance of propionylcarnitine CTD PMID:39172838 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189
JBrowse link
parthenolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO parthenolide results in decreased expression of ABCB1 protein CTD PMID:37683593 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions ISO parthenolide binds to and results in increased activity of ADIPOR2 protein CTD PMID:23691032 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666
JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of AMH mRNA] CTD PMID:37949423 NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867
JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO parthenolide results in decreased expression of ATF4 protein CTD PMID:36477977 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO parthenolide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of ATG7 protein] CTD PMID:37858773 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO parthenolide results in increased expression of BAK1 protein CTD PMID:16024633 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO parthenolide results in increased expression of BAX protein CTD PMID:16024633 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 protein]
parthenolide results in decreased expression of BCL2 mRNA; parthenolide results in decreased expression of BCL2 protein
CTD PMID:20154269 PMID:21928377 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to parthenolide CTD PMID:16024633 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO parthenolide results in increased cleavage of BID protein CTD PMID:16024633 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
JBrowse link
G C5 complement C5 multiple interactions ISO parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468
JBrowse link
G Casp3 caspase 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA] CTD PMID:30259999 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein CTD PMID:20154269 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Cat catalase multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of CAT mRNA] CTD PMID:37949423 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
CTD PMID:15728586 PMID:22748497 PMID:23958496 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein]
parthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 protein
CTD PMID:21928377 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292
JBrowse link
G Cfb complement factor B decreases expression ISO parthenolide results in decreased expression of CFB mRNA CTD PMID:16921510 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO parthenolide results in increased expression of CTNNB1 protein CTD PMID:37683593 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]
parthenolide results in increased expression of CXCL1 mRNA
CTD PMID:17320037 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Dazl deleted in azoospermia-like multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of DAZL mRNA] CTD PMID:37949423 NCBI chr 9:18,193,363...18,210,100
Ensembl chr 9:18,193,363...18,210,100
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO parthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA]
parthenolide results in increased expression of DDIT3 mRNA; parthenolide results in increased expression of DDIT3 protein
CTD PMID:11360202 PMID:36477977 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO parthenolide results in decreased expression of EIF2AK2 protein CTD PMID:36477977 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:21,952,631...21,977,116
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression ISO parthenolide results in decreased expression of EIF2AK3 protein CTD PMID:36477977 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO parthenolide results in decreased expression of ERO1A protein CTD PMID:36477977 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO parthenolide results in decreased expression of FAS mRNA CTD PMID:16024633 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Faslg Fas ligand decreases expression ISO parthenolide results in decreased expression of FASLG mRNA CTD PMID:16024633 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] CTD PMID:16921510 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 multiple interactions ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of FLT3 mRNA] CTD PMID:21928377 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GPX2 mRNA] CTD PMID:37949423 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862
JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression ISO parthenolide affects the expression of GPX4 protein CTD PMID:36591540 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased activity of GSR protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSR mRNA] CTD PMID:37949423 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSTA5 mRNA] CTD PMID:37949423 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein CTD PMID:21669866 NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:95,702,392...95,938,501
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO parthenolide results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO parthenolide inhibits the reaction [resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [resveratrol results in increased expression of ICAM1 mRNA] CTD PMID:22748497 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Ifna1 interferon, alpha 1 decreases expression ISO parthenolide results in decreased expression of IFNA1 mRNA CTD PMID:16921510 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911
JBrowse link
G Il12b interleukin 12B decreases expression ISO parthenolide results in decreased expression of IL12B mRNA CTD PMID:16921510 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO parthenolide results in decreased expression of IL1A mRNA CTD PMID:16921510 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein] CTD PMID:24444433 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL6 protein]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of IL6 mRNA]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]
CTD PMID:22748497 PMID:23958496 PMID:24444433 PMID:30259999 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO parthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA] CTD PMID:12574384 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO parthenolide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of MAP1LC3B protein] CTD PMID:37858773 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO
EXP
parthenolide results in increased expression of MAPK8 mRNA
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]
parthenolide results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD PMID:16921510 PMID:30259999 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO parthenolide results in increased expression of MAPK9 mRNA CTD PMID:16921510 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter] CTD PMID:20093109 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects localization
multiple interactions
ISO parthenolide affects the localization of NCOR2 protein
SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]
CTD PMID:21928377 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
CTD PMID:16921510 PMID:18463201 PMID:30259999 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide inhibits the reaction [bisphenol A results in increased expression of NFKBIA mRNA]
CTD PMID:18413660 PMID:18463201 PMID:19303104 PMID:38701888 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in increased expression of NOS2 protein]; parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] CTD PMID:30259999 PMID:37949423 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO parthenolide results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15728586 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases phosphorylation ISO parthenolide results in increased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein CTD PMID:21669866 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA]
CTD PMID:19095747 PMID:19303104 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity
ISO
EXP
parthenolide affects the localization of RELA protein
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein modified form]
parthenolide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of RELA mRNA]; parthenolide inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]
parthenolide results in decreased activity of RELA protein
[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]; parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; SC-203048 promotes the reaction [parthenolide affects the localization of RELA protein]
CTD PMID:16921510 PMID:18413660 PMID:18463201 PMID:19095747 PMID:19284563 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rtkn rhotekin multiple interactions ISO parthenolide inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates] CTD PMID:15480428 NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:117,198,647...117,215,660
JBrowse link
G Sele selectin E decreases expression ISO parthenolide results in decreased expression of SELE mRNA CTD PMID:16921510 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
JBrowse link
G Selp selectin P decreases expression ISO parthenolide results in decreased expression of SELP mRNA CTD PMID:16921510 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO parthenolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of SOD1 mRNA] CTD PMID:37949423 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sts steroid sulfatase multiple interactions ISO parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:46,102,548...46,111,104
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein CTD PMID:21669866 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969
JBrowse link
G Tjp1 tight junction protein 1 increases expression ISO parthenolide results in increased expression of TJP1 protein CTD PMID:37683593 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
G Tlr5 toll-like receptor 5 decreases expression ISO parthenolide results in decreased expression of TLR5 mRNA CTD PMID:16921510 NCBI chr13:97,166,430...97,190,642
Ensembl chr13:97,166,405...97,192,525
JBrowse link
G Tlr6 toll-like receptor 6 decreases expression ISO parthenolide results in decreased expression of TLR6 mRNA CTD PMID:16921510 NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,698,751...43,740,462
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of TNF mRNA]]; parthenolide inhibits the reaction [Resveratrol results in increased expression of TNF mRNA]; parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
parthenolide results in decreased activity of TNF protein
CTD PMID:19303104 PMID:20093109 PMID:22748497 PMID:30259999 PMID:38701888 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 increases expression ISO parthenolide results in increased expression of TP53 protein CTD PMID:16024633 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO parthenolide results in increased expression of TRADD mRNA CTD PMID:16921510 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]
parthenolide results in decreased expression of TRAF1 mRNA; parthenolide results in decreased expression of TRAF1 protein
CTD PMID:16921510 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA]
parthenolide results in decreased expression of TRAF2 mRNA; parthenolide results in decreased expression of TRAF2 protein
CTD PMID:16921510 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO parthenolide inhibits the reaction [Glupearl 19S results in increased expression of TSLP mRNA] CTD PMID:32493875 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression
multiple interactions
ISO parthenolide results in decreased expression of VCAM1 mRNA
parthenolide inhibits the reaction [bisphenol A results in increased expression of VCAM1 mRNA]
CTD PMID:16921510 PMID:38701888 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] CTD PMID:16921510 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700009N14Rikl RIKEN cDNA 1700009N14 gene like increases expression EXP Phenacetin results in increased expression of 1700009N14RIKL mRNA CTD PMID:17698508 NCBI chr 5:59,252,092...59,253,468
Ensembl chr 5:59,251,970...59,265,163
JBrowse link
G Aadac arylacetamide deacetylase increases hydrolysis ISO
EXP
AADAC protein results in increased hydrolysis of Phenacetin CTD PMID:22207054 NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525
JBrowse link
G Ahsp alpha hemoglobin stabilizing protein increases expression EXP Phenacetin results in increased expression of AHSP mRNA CTD PMID:17082564 NCBI chr 1:192,310,306...192,315,943
Ensembl chr 1:192,310,244...192,315,942
JBrowse link
G Akap10 A-kinase anchoring protein 10 increases expression EXP Phenacetin results in increased expression of AKAP10 mRNA CTD PMID:17082564 NCBI chr10:47,044,819...47,108,153
Ensembl chr10:47,044,819...47,108,203
JBrowse link
G Akr1b15 aldo-keto reductase family 1 member B15 increases expression EXP Phenacetin results in increased expression of AKR1B8 mRNA CTD PMID:17698508 NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP Phenacetin results in increased expression of ALAS2 mRNA CTD PMID:17082564 NCBI chr  X:22,890,650...22,914,046
Ensembl chr  X:22,890,689...22,914,043
JBrowse link
G Cd7 Cd7 molecule decreases expression EXP Phenacetin results in decreased expression of CD7 mRNA CTD PMID:17698508 NCBI chr10:106,802,373...106,805,269
Ensembl chr10:106,802,383...106,805,294
JBrowse link
G Cd8a CD8 subunit alpha decreases expression EXP Phenacetin results in decreased expression of CD8A mRNA CTD PMID:17698508 NCBI chr 4:104,924,116...104,928,353
Ensembl chr 4:104,900,833...104,928,358
JBrowse link
G Ceacam4 CEA cell adhesion molecule 4 increases expression EXP Phenacetin results in increased expression of CEACAM10 mRNA CTD PMID:17082564 NCBI chr 1:89,504,555...89,510,831
Ensembl chr 1:89,504,555...89,510,831
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Phenacetin results in increased expression of CHCHD6 mRNA CTD PMID:17698508 NCBI chr 4:123,360,729...123,581,429
Ensembl chr 4:123,349,187...123,581,421
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP Phenacetin results in increased expression of CREG1 mRNA CTD PMID:17698508 NCBI chr13:80,552,779...80,565,272
Ensembl chr13:80,549,933...80,565,272
JBrowse link
G Ctsb cathepsin B increases expression EXP Phenacetin results in increased expression of CTSB mRNA CTD PMID:17698508 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
JBrowse link
G Ctsd cathepsin D increases expression EXP Phenacetin results in increased expression of CTSD mRNA CTD PMID:17698508 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing
multiple interactions
increases metabolic processing
EXP
ISO
CYP1A1 protein affects the metabolism of Phenacetin
[CYP1A1 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen
CTD PMID:15231049 PMID:15879494 PMID:32198085 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
increases oxidation
decreases ethylation
affects metabolic processing
increases expression
increases activity
ISO
EXP
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [CYP1A2 protein results in decreased ethylation of Phenacetin]; 2-aminofluorene inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; 4-amino-2-phenoxymethanesulfonanilide promotes the reaction [CYP1A2 protein results in increased oxidation of Phenacetin]; 8-phenyltheophylline inhibits the reaction [CYP1A2 protein results in decreased ethylation of Phenacetin]; [5-bromotryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-chlorotryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-fluorotryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-methyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [7-methyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Amiodarone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [indopan analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [indopan results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Methoxydimethyltryptamines analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [N,N-diisopropyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; [Tryptamines analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; CYP1A2 protein results in increased oxidation of and results in decreased ethylation of Phenacetin; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; O(6)-benzylguanine inhibits the reaction [CYP1A2 protein affects the metabolism of Phenacetin]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; Oleanolic Acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; zileuton inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
CYP1A2 protein results in increased oxidation of Phenacetin; CYP1A2 protein results in increased oxidation of Phenacetin analog
[CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; Norfloxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
Phenacetin results in increased expression of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; Phenacetin inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]
Phenacetin results in increased activity of CYP1A2 protein
CTD PMID:1567206 PMID:3577206 PMID:8020169 PMID:8905919 PMID:9195021 More... NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 affects metabolic processing EXP CYP2A2 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr 1:91,391,492...91,417,158
Ensembl chr 1:91,391,502...91,417,158
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects metabolic processing EXP CYP2C13 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP Phenacetin results in decreased expression of CYP2C22 mRNA CTD PMID:17082564 NCBI chr 1:248,941,143...248,980,767
Ensembl chr 1:248,904,062...248,971,182
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing
decreases ethylation
EXP CYP2C6 protein affects the metabolism of Phenacetin
CYP2C6 protein results in decreased ethylation of Phenacetin
CTD PMID:11911841 PMID:15231049 PMID:15879494 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects metabolic processing EXP CYP2D1 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:115,789,023...115,793,479
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 affects metabolic processing EXP CYP2D26 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing EXP CYP3A2 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of Phenacetin CTD PMID:15879494 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases ethylation ISO CYP46A1 protein results in decreased ethylation of Phenacetin CTD PMID:14640697 NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:133,011,989...133,041,971
JBrowse link
G Emb embigin increases expression EXP Phenacetin results in increased expression of EMB mRNA CTD PMID:17082564 NCBI chr 2:50,803,468...50,858,001
Ensembl chr 2:50,801,973...50,862,920
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP Phenacetin results in increased expression of FABP4 mRNA CTD PMID:17698508 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP Phenacetin results in increased expression of FABP5 mRNA CTD PMID:17698508 NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127
JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression EXP Phenacetin results in increased expression of FCGR2B mRNA CTD PMID:17082564 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517
JBrowse link
G Flg filaggrin increases expression EXP Phenacetin results in increased expression of FLG mRNA CTD PMID:17082564 NCBI chr 2:181,583,801...181,596,464
Ensembl chr 2:181,583,808...181,595,968
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Phenacetin results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G Frem2 FRAS1 related extracellular matrix 2 decreases expression EXP Phenacetin results in decreased expression of FREM2 mRNA CTD PMID:17082564 NCBI chr 2:139,753,055...139,891,046
Ensembl chr 2:139,753,055...139,891,046
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP Phenacetin results in increased expression of FTL1 mRNA CTD PMID:17698508 NCBI chr 1:105,072,858...105,074,705
Ensembl chr  X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915
JBrowse link
G G0s2 G0/G1switch 2 decreases expression EXP Phenacetin results in decreased expression of G0S2 mRNA CTD PMID:17082564 NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293
JBrowse link
G Gcgr glucagon receptor increases expression EXP Phenacetin results in increased expression of GCGR mRNA CTD PMID:17698508 NCBI chr10:106,306,803...106,314,970
Ensembl chr10:106,306,559...106,314,969
JBrowse link
G Gfra1 GDNF family receptor alpha 1 increases expression EXP Phenacetin results in increased expression of GFRA1 mRNA CTD PMID:17698508 NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Phenacetin results in increased expression of GPNMB mRNA CTD PMID:17082564 PMID:17698508 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240
JBrowse link
G Gzmk granzyme K decreases expression EXP Phenacetin results in decreased expression of GZMK mRNA CTD PMID:17698508 NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression EXP Phenacetin results in increased expression of HBA-A1 mRNA CTD PMID:17082564 NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,841,763...15,842,603
JBrowse link
G Hbe2 hemoglobin, epsilon 2 increases expression EXP Phenacetin results in increased expression of HBE2 mRNA CTD PMID:17082564 NCBI chr 1:167,691,174...167,692,802
Ensembl chr 1:167,683,760...167,706,139
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Phenacetin results in increased expression of HMOX1 mRNA; Phenacetin results in increased expression of HMOX1 protein CTD PMID:17082564 PMID:17698508 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Phenacetin results in decreased expression of IGF1 mRNA CTD PMID:23142791 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Phenacetin results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
JBrowse link
G Klre1 killer cell lectin like receptor E1 decreases expression EXP Phenacetin results in decreased expression of KLRE1 mRNA CTD PMID:17698508 NCBI chr 4:164,719,307...164,727,664
Ensembl chr 4:164,719,604...164,727,664
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Phenacetin results in increased expression of LAMC2 mRNA CTD PMID:23142791 NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Phenacetin results in increased expression of LBP mRNA CTD PMID:17082564 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518
JBrowse link
G Lgals3 galectin 3 increases expression EXP Phenacetin results in increased expression of LGALS3 mRNA CTD PMID:17082564 PMID:17698508 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737
JBrowse link
G Lgmn legumain increases expression EXP Phenacetin results in increased expression of LGMN mRNA CTD PMID:17698508 NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:127,308,913...127,347,328
JBrowse link
G Mt1a metallothionein 1A increases expression EXP Phenacetin results in increased expression of MT1A mRNA CTD PMID:17082564 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200
JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression EXP Phenacetin results in decreased expression of NCK2 mRNA CTD PMID:17082564 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:53,231,381...53,332,394
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Phenacetin results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Npy neuropeptide Y increases expression EXP Phenacetin results in increased expression of NPY mRNA CTD PMID:17082564 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Phenacetin results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP Phenacetin results in increased expression of ORC1 mRNA CTD PMID:17698508 NCBI chr 5:128,552,975...128,581,943
Ensembl chr 5:128,552,991...128,577,071
JBrowse link
G Pepd peptidase D decreases activity ISO Phenacetin results in decreased activity of PEPD protein CTD PMID:16991207 NCBI chr 1:96,673,624...96,818,197
Ensembl chr 1:96,673,607...96,818,190
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression EXP Phenacetin results in increased expression of PLSCR1 mRNA CTD PMID:17082564 NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:101,664,056...101,684,614
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression EXP Phenacetin results in increased expression of PSMD6 mRNA CTD PMID:17082564 NCBI chr15:13,532,675...13,542,682
Ensembl chr15:13,532,675...13,542,682
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Phenacetin analog results in decreased activity of PTGS1 protein; Phenacetin results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression EXP Phenacetin results in increased expression of PTPMT1 mRNA CTD PMID:17698508 NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:97,345,752...97,355,254
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Phenacetin results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680
JBrowse link
G Rhd Rh blood group, D antigen increases expression EXP Phenacetin results in increased expression of RHD mRNA CTD PMID:17082564 NCBI chr 5:152,371,160...152,405,396
Ensembl chr 5:152,371,200...152,405,395
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression EXP Phenacetin results in increased expression of RIPK3 mRNA CTD PMID:17082564 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression EXP Phenacetin results in decreased expression of RT1-BB mRNA CTD PMID:17698508 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Phenacetin results in increased expression of S100A8 mRNA CTD PMID:17082564 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Phenacetin results in increased expression of S100A9 mRNA CTD PMID:17082564 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870
JBrowse link
G Serpina3n serpin family A member 3N increases expression EXP Phenacetin results in increased expression of SERPINA3N mRNA CTD PMID:17698508 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Phenacetin results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Phenacetin results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Phenacetin results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression EXP Phenacetin results in increased expression of SLC39A14 mRNA CTD PMID:17082564 NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229
JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression EXP Phenacetin results in increased expression of SLC40A1 mRNA CTD PMID:17082564 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Phenacetin results in increased expression of SPINK1 mRNA CTD PMID:17082564 NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545
JBrowse link
G Spmip7 sperm microtubule inner protein 7 increases expression EXP Phenacetin results in increased expression of SPMIP7 mRNA CTD PMID:17698508 NCBI chr14:90,244,087...90,299,294
Ensembl chr14:90,244,289...90,299,293
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 decreases expression EXP Phenacetin results in decreased expression of TNFRSF17 mRNA CTD PMID:17698508 NCBI chr10:4,808,023...4,813,857 JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Phenacetin results in increased expression of TRIB3 mRNA CTD PMID:17082564 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases response to substance EXP UGT1A1 gene mutant form results in increased susceptibility to Phenacetin CTD PMID:6776978 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Phenacetin results in increased expression of VCAM1 mRNA CTD PMID:17082564 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases response to substance ISO XPA gene mutant form results in increased susceptibility to Phenacetin CTD PMID:16464479 NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 decreases expression EXP Phenacetin results in decreased expression of ZBTB44 mRNA CTD PMID:17082564 NCBI chr 8:37,724,237...37,782,220
Ensembl chr 8:37,724,250...37,776,691
JBrowse link
phenylbutazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Phenylbutazone results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Phenylbutazone inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15489888 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Phenylbutazone inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases activity
multiple interactions
ISO Phenylbutazone results in increased expression of CYP3A4 mRNA
Phenylbutazone results in increased activity of CYP3A4 protein
NR3C1 protein promotes the reaction [Phenylbutazone results in increased expression of CYP3A4 mRNA]
CTD PMID:9512926 PMID:10219967 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenylbutazone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Phenylbutazone results in increased expression of HAVCR1 mRNA CTD PMID:23142791 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
JBrowse link
G Krt14 keratin 14 increases expression EXP Phenylbutazone results in increased expression of KRT14 mRNA CTD PMID:23142791 NCBI chr10:85,638,182...85,642,450 JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Phenylbutazone results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Phenylbutazone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Phenylbutazone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Phenylbutazone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:15489888 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein promotes the reaction [Phenylbutazone results in increased expression of CYP3A4 mRNA] CTD PMID:10219967 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Phenylbutazone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15489888 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Phenylbutazone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Phenylbutazone inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15489888 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Phenylbutazone results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392
JBrowse link
G Sell selectin L affects expression ISO Phenylbutazone affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Phenylbutazone results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Phenylbutazone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Phenylbutazone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Phenylbutazone inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Phenylbutazone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Phenylbutazone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Phenylbutazone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Phenylbutazone inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Phenylbutazone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
[Phenylbutazone co-treated with Lipopolysaccharides] results in increased secretion of TNF protein
CTD PMID:10328874 PMID:15489888 PMID:17328244 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Phenylbutazone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol] CTD PMID:23126256 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO Phenylbutazone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Diethylstilbestrol] CTD PMID:23126256 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
procaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of AKT1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]
CTD PMID:32061592 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Procaine results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Procaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
JBrowse link
G Capn1 calpain 1 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein] CTD PMID:26998625 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445
JBrowse link
G Capn2 calpain 2 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein] CTD PMID:26998625 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 PMID:26998625 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein] CTD PMID:26998625 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions
ISO Procaine results in decreased expression of CDH5 protein
HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]
CTD PMID:32061592 NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Procaine CTD PMID:9300133 PMID:15475733 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Procaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
ISO [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin] CTD PMID:32061592 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein CTD PMID:26998625 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of ITPR1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]
CTD PMID:32061592 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]
CTD PMID:32061592 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]
CTD PMID:32061592 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Procaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]
CTD PMID:32061592 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Procaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA] CTD PMID:33476690 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP Rosmarinic Acid results in decreased expression of ACTA2 protein
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:28789951 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 decreases expression
multiple interactions
ISO Rosmarinic Acid results in decreased expression of ADAM17 protein
[Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]
CTD PMID:23774263 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein] CTD PMID:33476690 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of AGER mRNA] CTD PMID:39848458 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Rosmarinic Acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] CTD PMID:21526214 PMID:23548128 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of ATF4 mRNA] CTD PMID:39848458 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Rosmarinic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of BAX mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of BAX protein]
CTD PMID:21526214 PMID:39848458 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Rosmarinic Acid inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2 protein]
CTD PMID:21526214 PMID:39848458 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2L1 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2L1 protein] CTD PMID:39848458 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Malathion results in increased expression of BIRC5 protein] CTD PMID:34262720 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP1 protein] CTD PMID:21526214 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO
EXP
Rosmarinic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Rosmarinic Acid results in increased expression of CASP3 mRNA
Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of CASP3 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
CTD PMID:20966113 PMID:21526214 PMID:23548128 PMID:28815802 PMID:36863647 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 increases expression
increases activity
ISO Rosmarinic Acid results in increased expression of CASP8 mRNA
Rosmarinic Acid results in increased activity of CASP8 protein
CTD PMID:36863647 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP9 protein] CTD PMID:21526214 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases activity
multiple interactions
increases expression
ISO Rosmarinic Acid results in increased activity of CAT protein
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]
Rosmarinic Acid results in increased expression of CAT mRNA
CTD PMID:31610155 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression
EXP Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
Rosmarinic Acid results in decreased expression of CCN2 mRNA
CTD PMID:28789951 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] CTD PMID:28789951 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cd68 Cd68 molecule decreases expression EXP Rosmarinic Acid results in decreased expression of CD68 protein CTD PMID:28789951 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Rosmarinic Acid results in decreased expression of COL1A1 mRNA
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
CTD PMID:27235791 PMID:28789951 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression
EXP Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]
Rosmarinic Acid results in decreased expression of COL3A1 mRNA
CTD PMID:28789951 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Crp C-reactive protein affects expression
multiple interactions
EXP Rosmarinic Acid affects the expression of CRP protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of CRP protein]
CTD PMID:28744220 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
multiple interactions
ISO Rosmarinic Acid results in decreased expression of CXCL1 mRNA
Rosmarinic Acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; Rosmarinic Acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]
CTD PMID:12684091 PMID:26804033 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Des desmin multiple interactions EXP Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein] CTD PMID:28789951 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Rosmarinic Acid results in decreased expression of DNMT1 protein CTD PMID:21078381 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of EIF2AK3 mRNA] CTD PMID:39848458 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of EIF2S1 mRNA] CTD PMID:39848458 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA] CTD PMID:33476690 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA] CTD PMID:33476690 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Rosmarinic Acid results in decreased expression of FN1 mRNA CTD PMID:26804033 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Rosmarinic Acid results in decreased expression of FOS protein CTD PMID:28789951 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity
multiple interactions
EXP Rosmarinic Acid results in decreased activity of GPT protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased activity of GPT protein]
CTD PMID:25455894 PMID:39848458 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO Rosmarinic Acid results in increased expression of GPX1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]
CTD PMID:31610155 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gsto1 glutathione S-transferase omega 1 multiple interactions
increases expression
ISO Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]
Rosmarinic Acid results in increased expression of GSTO1 mRNA
CTD PMID:31610155 NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of HAVCR1 protein] CTD PMID:39848458 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects expression
ISO Rosmarinic Acid promotes the reaction [Lipopolysaccharides results in decreased expression of HIF1A protein]
Rosmarinic Acid affects the expression of HIF1A protein
CTD PMID:38103880 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression EXP Rosmarinic Acid results in decreased expression of HMGB1 protein CTD PMID:28789951 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Rosmarinic Acid results in increased expression of HMOX1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]
CTD PMID:31610155 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA] CTD PMID:33476690 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA] CTD PMID:33476690 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of IL1B protein]
Rosmarinic Acid results in decreased expression of IL1B mRNA; Rosmarinic Acid results in decreased expression of IL1B protein
Rosmarinic Acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; Rosmarinic Acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Rosmarinic Acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]
CTD PMID:12684091 PMID:23548128 PMID:23774263 PMID:25455894 PMID:28789951 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases expression
affects expression
ISO
EXP
Rosmarinic Acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
Rosmarinic Acid results in decreased expression of IL6 protein
Rosmarinic Acid results in decreased expression of IL6 mRNA
Rosmarinic Acid results in increased expression of IL6 mRNA
Rosmarinic Acid affects the expression of IL6 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of IL6 protein]
CTD PMID:23548128 PMID:26804033 PMID:28744220 PMID:28789951 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP Rosmarinic Acid results in decreased phosphorylation of JUN protein CTD PMID:28789951 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 decreases activity ISO Rosmarinic Acid results in decreased activity of KCNU1 protein CTD PMID:30009954 NCBI chr16:72,844,692...72,932,216
Ensembl chr16:72,844,712...72,932,334
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression
multiple interactions
ISO Rosmarinic Acid results in decreased expression of KEAP1 protein
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]
CTD PMID:31610155 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions EXP Rosmarinic Acid inhibits the reaction [Malathion results in increased expression of KIT protein] CTD PMID:34262720 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Rosmarinic Acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631
JBrowse link
G Maob monoamine oxidase B decreases activity ISO Rosmarinic Acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP Rosmarinic Acid results in decreased phosphorylation of MAP3K7 protein CTD PMID:28789951 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Rosmarinic Acid results in decreased phosphorylation of MAPK1 protein CTD PMID:28789951 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Rosmarinic Acid results in decreased phosphorylation of MAPK3 protein CTD PMID:28789951 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP Rosmarinic Acid results in decreased phosphorylation of MAPK8 protein CTD PMID:28789951 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation EXP Rosmarinic Acid results in decreased phosphorylation of MAPK9 protein CTD PMID:28789951 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Rosmarinic Acid results in decreased expression of MMP2 mRNA; Rosmarinic Acid results in decreased expression of MMP2 protein CTD PMID:28789951 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Rosmarinic Acid results in decreased expression of MMP9 mRNA; Rosmarinic Acid results in decreased expression of MMP9 protein CTD PMID:28789951 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase decreases expression EXP Rosmarinic Acid results in decreased expression of MPO protein CTD PMID:28789951 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression EXP Rosmarinic Acid results in decreased expression of MYD88 protein CTD PMID:28789951 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO Rosmarinic Acid results in increased expression of NFE2L2 mRNA; Rosmarinic Acid results in increased expression of NFE2L2 protein
[lead acetate results in increased abundance of Lead] inhibits the reaction [Rosmarinic Acid results in increased expression of NFE2L2 protein]; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; Rosmarinic Acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]
CTD PMID:31610155 PMID:33476690 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of NFKB1 mRNA] CTD PMID:39848458 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA
Rosmarinic Acid inhibits the reaction [Cisplatin results in increased degradation of NFKBIA protein]
CTD PMID:21526214 PMID:33476690 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression
multiple interactions
ISO
EXP
Rosmarinic Acid results in decreased expression of NLRP3 mRNA
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of NLRP3 mRNA]
CTD PMID:36863647 PMID:39848458 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression
decreases expression
EXP
ISO
Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
Rosmarinic Acid affects the expression of NOS2 protein
Rosmarinic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Rosmarinic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Rosmarinic Acid results in decreased expression of NOS2 protein
CTD PMID:25455894 PMID:28815802 PMID:38103880 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP Rosmarinic Acid results in decreased expression of NOS3 protein CTD PMID:25455894 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of NPHS1 protein] CTD PMID:39848458 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]
Rosmarinic Acid results in increased expression of NQO1 mRNA
CTD PMID:31610155 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP Rosmarinic Acid results in increased expression of OGG1 mRNA CTD PMID:18996367 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase decreases activity ISO Rosmarinic Acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of PARP1 mRNA] CTD PMID:39848458 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA] CTD PMID:33476690 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA] CTD PMID:33476690 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
EXP
ISO
Rosmarinic Acid affects the expression of PPARG mRNA; Rosmarinic Acid affects the expression of PPARG protein
Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of PPARG protein]
CTD PMID:28744220 PMID:33476690 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA] CTD PMID:33476690 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
G Procr protein C receptor affects localization
multiple interactions
ISO Rosmarinic Acid affects the localization of PROCR protein
Rosmarinic Acid results in decreased cleavage of and results in decreased secretion of PROCR protein
[Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; Rosmarinic Acid results in decreased cleavage of and results in decreased secretion of PROCR protein
CTD PMID:23774263 NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989
JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions
affects expression
ISO Rosmarinic Acid promotes the reaction [Lipopolysaccharides results in increased expression of RACK1 protein]
Rosmarinic Acid affects the expression of RACK1 protein
CTD PMID:38103880 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects expression
decreases phosphorylation
affects localization
EXP
ISO
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of RELA protein]
Rosmarinic Acid inhibits the reaction [Cisplatin affects the localization of RELA protein]
Rosmarinic Acid affects the expression of RELA mRNA; Rosmarinic Acid affects the expression of RELA protein
Rosmarinic Acid results in decreased phosphorylation of RELA protein
Rosmarinic Acid affects the localization of RELA protein
CTD PMID:21526214 PMID:25455894 PMID:28744220 PMID:28789951 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Rosmarinic Acid results in decreased expression of SERPINE1 mRNA CTD PMID:26804033 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Sftpb surfactant protein B multiple interactions EXP Rosmarinic Acid inhibits the reaction [Malathion results in decreased expression of SFTPB protein] CTD PMID:34262720 NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:105,917,578...105,927,646
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]
Rosmarinic Acid results in increased expression of SOD1 mRNA
CTD PMID:31610155 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]
Rosmarinic Acid results in increased expression of SOD2 mRNA
CTD PMID:31610155 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA] CTD PMID:33476690 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Tf transferrin multiple interactions ISO [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
EXP
ISO
Rosmarinic Acid results in decreased expression of TGFB1 protein
[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD PMID:28789951 PMID:33476690 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP Rosmarinic Acid results in decreased expression of TLR4 protein CTD PMID:28789951 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions
decreases expression
EXP
ISO
Rosmarinic Acid affects the expression of TNF protein
Rosmarinic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rosmarinic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Rosmarinic Acid results in decreased expression of TNF mRNA; Rosmarinic Acid results in decreased expression of TNF protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of TNF mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of TNF protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]
[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
CTD PMID:23774263 PMID:25455894 PMID:28744220 PMID:28789951 PMID:28815802 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420
JBrowse link
G Vim vimentin multiple interactions EXP Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:28789951 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
suprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Suprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Suprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Suprofen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
JBrowse link
suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase L/R decreases activity EXP suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 decreases activity ISO zardaverine results in decreased activity of AKR1D1 protein CTD PMID:39988211 NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540
JBrowse link
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link

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  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            peripheral nervous system drug 1368
              (S)-nicotine + 1164
              4-(methylamino)antipyrine 0
              4-aminoantipyrine 0
              O-propanoyl-L-carnitine + 3
              O-propanoylcarnitine + 3
              acetosyringone 0
              alfentanil 4
              alpha-methyl-L-dopa 6
              apocynin 141
              aprepitant 25
              chloroprocaine + 4
              chloroprocaine hydrochloride 0
              ecgonine methyl ester 1
              metamizole 0
              metamizole sodium 7
              nicotine 1164
              parthenolide 82
              phenacetin 80
              phenylbutazone 20
              procaine 18
              propyphenazone 0
              rosmarinic acid + 88
              suprofen 3
              suxibuzone 1
              zardaverine 4
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