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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clavulanic acid
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Accession:CHEBI:48947 term browser browse the term
Definition:Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.
Synonyms:related_synonym: (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID;   (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid;   Clavulanate;   Clavulansaeure;   Formula=C8H9NO5;   InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1;   InChIKey=HZZVJAQRINQKSD-PBFISZAISA-N;   MM 14151;   SMILES=[H][C@@]12CC(=O)N1[C@@H](C(O)=O)\\C(O2)=C\\CO;   acide clavulanique;   acido clavulanico;   acidum clavulanicum;   antibiotic MM 14151;   clavulonic acid
 alt_id: CHEBI:3736;   CHEBI:43442
 xref: Beilstein:787059;   CAS:58001-44-8;   DrugBank:DB00766;   Drug_Central:669;   HMDB:HMDB0014904;   KEGG:C06662;   KEGG:D07711;   KNApSAcK:C00018091
 xref_mesh: MESH:D019818
 xref: PDBeChem:J01;   PMID:11092620;   PMID:12413541;   PMID:18450406;   PMID:19394358;   PMID:25047044;   PMID:25477926;   PMID:25763134;   PMID:25844706;   PMID:25998949;   PMID:27731424;   PMID:9131470;   Patent:DE2517316;   Reaxys:787059;   VSDB:1930;   Wikipedia:Clavulanic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:487869


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clavulanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions		 ISO Clavulanic Acid results in decreased expression of ABCB11 mRNA
Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]		 CTD PMID:34767876 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO Clavulanic Acid results in decreased expression of ABCB4 mRNA CTD PMID:34767876 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Clavulanic Acid results in increased expression of ABCC2 mRNA CTD PMID:34767876 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression
multiple interactions		 ISO Clavulanic Acid results in decreased expression of ABCG5 mRNA
Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; GW 4064 inhibits the reaction [Clavulanic Acid results in decreased expression of ABCG5 mRNA]		 CTD PMID:34767876 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Clavulanic Acid results in increased expression of AKR1B10 mRNA CTD PMID:34767876 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Clavulanic Acid results in decreased expression of CYP27A1 mRNA CTD PMID:34767876 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Clavulanic Acid results in decreased expression of CYP7A1 mRNA CTD PMID:34767876 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Clavulanic Acid results in decreased expression of CYP8B1 mRNA CTD PMID:34767876 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ereg epiregulin increases expression
decreases expression		 ISO Clavulanic Acid results in increased expression of EREG mRNA
Clavulanic Acid results in decreased expression of EREG mRNA		 CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression ISO Clavulanic Acid results in increased expression of FGF19 mRNA CTD PMID:34767876 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Clavulanic Acid results in increased expression of G6PD mRNA CTD PMID:34767876 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Clavulanic Acid results in increased expression of GCLC mRNA CTD PMID:34767876 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Clavulanic Acid results in increased expression of GCLM mRNA CTD PMID:34767876 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Clavulanic Acid results in increased expression of GPX2 mRNA CTD PMID:34767876 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Clavulanic Acid results in increased expression of GSR mRNA CTD PMID:34767876 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Clavulanic Acid results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Clavulanic Acid results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 increases expression
decreases expression		 ISO Clavulanic Acid results in increased expression of IL24 mRNA
Clavulanic Acid results in decreased expression of IL24 mRNA		 CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Lss lanosterol synthase decreases expression ISO Clavulanic Acid results in decreased expression of LSS mRNA CTD PMID:34767876 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Clavulanic Acid results in increased expression of ME1 mRNA CTD PMID:34767876 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Clavulanic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mvk mevalonate kinase decreases expression ISO Clavulanic Acid results in decreased expression of MVK mRNA CTD PMID:34767876 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clavulanic Acid results in increased expression of NR0B2 mRNA CTD PMID:34767876 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Clavulanic Acid results in decreased expression of SCD mRNA CTD PMID:34767876 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Clavulanic Acid results in decreased expression of SLC10A1 mRNA CTD PMID:34767876 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc51a solute carrier family 51 member A decreases expression
multiple interactions		 ISO Clavulanic Acid results in decreased expression of SLC51A mRNA
Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of SLC51A mRNA]		 CTD PMID:34767876 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
increases expression		 ISO Clavulanic Acid results in decreased expression of SLC7A11 mRNA
Clavulanic Acid results in increased expression of SLC7A11 mRNA		 CTD PMID:32816093 PMID:34767876 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Clavulanic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Clavulanic Acid results in decreased expression of SREBF1 mRNA CTD PMID:34767876 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tkt transketolase increases expression ISO Clavulanic Acid results in increased expression of TKT mRNA CTD PMID:34767876 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Clavulanic Acid results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Clavulanic Acid results in increased expression of TXNRD1 mRNA CTD PMID:34767876 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        antimicrobial agent 18251
          antibacterial agent 16372
            antibacterial drug 7397
              clavulanic acid 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              lactam 8389
                                                beta-lactam 831
                                                  oxapenam 32
                                                    clavulanic acid 32
paths to the root