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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-(hydroxymethyl)glutathione
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Accession:CHEBI:48926 term browser browse the term
Definition:An S-substituted glutathione that is glutathione in which the mercapto hydrogen has been replaced by a hydroxymethyl group.
Synonyms:related_synonym: Formula=C11H19N3O7S;   InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1;   InChIKey=PIUSLWSYOYFRFR-BQBZGAKWSA-N;   L-gamma-glutamyl-S-(hydroxymethyl)-L-cysteinylglycine;   S-hydroxymethylglutathione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSCO)C(=O)NCC(O)=O)C(O)=O
 alt_id: CHEBI:34963;   CHEBI:40619
 xref: CAS:32260-87-0;   KEGG:C14180
 xref_mesh: MESH:C029469
 xref: PDBeChem:AHE
 cyclic_relationship: is_conjugate_acid_of CHEBI:58758



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S-(hydroxymethyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation
multiple interactions
ISO ADH5 protein results in increased oxidation of S-hydroxymethylglutathione
Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione]
CTD PMID:23220590 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      chemical role 19507
        antioxidant 16171
          glutathione 387
            glutathione derivative 58
              S-substituted glutathione 6
                S-(hydroxymethyl)glutathione 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              peptide 11432
                                                oligopeptide 1348
                                                  tripeptide 986
                                                    glutathione 387
                                                      glutathione derivative 58
                                                        S-substituted glutathione 6
                                                          S-(hydroxymethyl)glutathione 1
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