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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzoimidazothiazole
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Accession:CHEBI:48904 term browser browse the term
Synonyms:related_synonym: benzoimidazothiazoles


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quizartinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of AKT1 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein] CTD PMID:25053825 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of BCL2 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of BCL2 protein] CTD PMID:25053825 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in increased expression of BCL2L11 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased expression of BCL2L11 protein] CTD PMID:25053825 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage 		ISO quizartinib affects the reaction [RGFP966 results in increased cleavage of CASP3 protein]; quizartinib promotes the reaction [romidepsin results in increased cleavage of CASP3 protein]; RGFP966 affects the reaction [quizartinib results in increased cleavage of CASP3 protein]; romidepsin promotes the reaction [quizartinib results in increased cleavage of CASP3 protein] CTD PMID:34665271 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK4 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK6 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein] CTD PMID:25053825 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in increased expression of CDKN1A protein]; quizartinib inhibits the reaction [RGFP966 results in increased expression of CDKN1A protein]; quizartinib inhibits the reaction [romidepsin results in increased expression of CDKN1A protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein]
quizartinib results in decreased expression of CDKN1A protein 		CTD PMID:25053825 PMID:34665271 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression
multiple interactions 		ISO quizartinib results in decreased expression of CHEK1 protein
quizartinib promotes the reaction [RGFP966 results in decreased expression of CHEK1 protein]; quizartinib results in decreased expression of and results in increased phosphorylation of CHEK1 protein; RGFP966 promotes the reaction [quizartinib results in decreased expression of CHEK1 protein]; romidepsin promotes the reaction [quizartinib results in decreased expression of and results in increased phosphorylation of CHEK1 protein] 		CTD PMID:34665271 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Ctsa cathepsin A multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSA protein CTD PMID:30821613 NCBI chr 3:173,988,443...173,994,320
Ensembl chr 3:173,988,460...173,995,539 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein CTD PMID:30821613 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSD protein CTD PMID:30821613 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein; [quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein; aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein] CTD PMID:30821613 NCBI chr  X:12,152,346...12,165,983
Ensembl chr  X:12,152,346...12,165,983 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein; [quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein; aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein] CTD PMID:30821613 NCBI chr10:54,883,093...54,888,602
Ensembl chr10:54,883,093...54,888,602 		JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein; [quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein; aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein] CTD PMID:30821613 NCBI chr12:27,719,527...27,736,350
Ensembl chr12:27,719,321...27,736,346 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 multiple interactions
decreases phosphorylation 		ISO quizartinib affects the reaction [RGFP966 results in decreased expression of and results in decreased phosphorylation of FLT3 protein alternative form]; quizartinib promotes the reaction [romidepsin results in decreased phosphorylation of FLT3 protein alternative form]; RGFP966 affects the reaction [quizartinib results in decreased phosphorylation of FLT3 protein alternative form]; romidepsin promotes the reaction [quizartinib results in decreased phosphorylation of FLT3 protein alternative form] CTD PMID:34665271 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation 		ISO quizartinib affects the reaction [RGFP966 results in increased phosphorylation of H2AX protein]; quizartinib promotes the reaction [romidepsin results in increased phosphorylation of H2AX protein]; RGFP966 affects the reaction [quizartinib results in increased phosphorylation of H2AX protein]; romidepsin promotes the reaction [quizartinib results in increased phosphorylation of H2AX protein] CTD PMID:34665271 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G H3f4 H3.4 histone, cluster member multiple interactions ISO quizartinib promotes the reaction [romidepsin results in increased acetylation of H3-4 protein] CTD PMID:34665271 NCBI chr10:44,240,282...44,240,842 JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 multiple interactions ISO quizartinib inhibits the reaction [(+)-JQ1 compound results in increased expression of HEXIM1 protein] CTD PMID:25053825 NCBI chr10:88,562,889...88,565,001
Ensembl chr10:88,560,519...88,580,000 		JBrowse link
G Hist1h4m histone cluster 1, H4m multiple interactions ISO quizartinib promotes the reaction [RGFP966 results in increased acetylation of H4C1 protein] CTD PMID:34665271 NCBI chr17:47,393,764...47,394,168
Ensembl chr17:47,393,603...47,453,972
Ensembl chr17:47,393,603...47,453,972
Ensembl chr 4:47,393,603...47,453,972
Ensembl chr17:47,393,603...47,453,972
Ensembl chr17:47,393,603...47,453,972 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein] CTD PMID:30821613 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HSPA8 protein alternative form CTD PMID:30821613 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein alternative form; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein] CTD PMID:30821613 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of MAPK1 protein]; quizartinib affects the reaction [RGFP966 results in decreased phosphorylation of MAPK1 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK1 protein]; quizartinib promotes the reaction [romidepsin results in decreased phosphorylation of MAPK1 protein]; RGFP966 affects the reaction [quizartinib results in decreased phosphorylation of MAPK1 protein]; romidepsin promotes the reaction [quizartinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:25053825 PMID:34665271 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of MAPK3 protein]; quizartinib affects the reaction [RGFP966 results in decreased phosphorylation of MAPK3 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK3 protein]; quizartinib promotes the reaction [romidepsin results in decreased phosphorylation of MAPK3 protein]; RGFP966 affects the reaction [quizartinib results in decreased phosphorylation of MAPK3 protein]; romidepsin promotes the reaction [quizartinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:25053825 PMID:34665271 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of MYC protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:25053825 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein] CTD PMID:30821613 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in increased cleavage of PARP1 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:25053825 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rad51 RAD51 recombinase decreases expression
multiple interactions 		ISO quizartinib results in decreased expression of RAD51 protein
quizartinib promotes the reaction [romidepsin results in decreased expression of RAD51 protein]; romidepsin promotes the reaction [quizartinib results in decreased expression of RAD51 protein] 		CTD PMID:34665271 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469 		JBrowse link
G Rpa2 replication protein A2 multiple interactions
increases phosphorylation 		ISO quizartinib affects the reaction [RGFP966 results in increased phosphorylation of RPA2 protein]; RGFP966 affects the reaction [quizartinib results in increased phosphorylation of RPA2 protein] CTD PMID:34665271 NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:150,260,723...150,271,546 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5A protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein] CTD PMID:25053825 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions
decreases phosphorylation 		ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5B protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein] CTD PMID:25053825 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Tp53 tumor protein p53 decreases expression
multiple interactions 		ISO quizartinib results in decreased expression of TP53 protein
RGFP966 promotes the reaction [quizartinib results in decreased expression of TP53 protein]; romidepsin promotes the reaction [quizartinib results in decreased expression of TP53 protein] 		CTD PMID:34665271 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tyms thymidylate synthetase decreases expression ISO quizartinib results in decreased expression of TYMS protein CTD PMID:34665271 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions
decreases expression 		ISO quizartinib promotes the reaction [RGFP966 results in decreased expression of WEE1 protein]; quizartinib promotes the reaction [romidepsin results in decreased expression of WEE1 protein]; RGFP966 promotes the reaction [quizartinib results in decreased expression of WEE1 protein]; romidepsin promotes the reaction [quizartinib results in decreased expression of WEE1 protein] CTD PMID:34665271 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              organonitrogen compound 19403
                organonitrogen heterocyclic compound 18546
                  benzoimidazothiazole 34
                    2-p-tolyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole 0
                    quizartinib 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterotricyclic compound 16078
                                      benzoimidazothiazole 34
                                        2-p-tolyl-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole 0
                                        quizartinib 34
paths to the root