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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridoindole
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Accession:CHEBI:48888 term browser browse the term
Synonyms:related_synonym: pyridoindoles


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2-Amino-3-methyl-9H-pyrido[2,3-b]indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP
ISO		 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA; 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein
lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein]		 CTD PMID:8902619 PMID:27644595 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 EXP
ISO		 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA; 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein
lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]
CYP1A2 protein results in increased activity of and results in increased hydroxylation of 2-amino-3-methyl-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole		 CTD PMID:8902619 PMID:14729582 PMID:27644595 PMID:28160022 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Ddc dopa decarboxylase decreases activity ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in decreased activity of DDC protein CTD PMID:2243617 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Nat2 N-acetyltransferase 2 increases activity
multiple interactions		 ISO NAT2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole
NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole		 CTD PMID:14729582 PMID:28160022 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity		 ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3-methyl-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A2 protein		 CTD PMID:30189235 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SULT1A1 protein results in increased activity of and results in increased sulfation of 2-amino-3-methyl-9H-pyrido(2,3-b)indole; SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole CTD PMID:14729582 PMID:28160022 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases activity ISO SULT1B1 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole CTD PMID:14729582 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A increases activity ISO SULT1C2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole CTD PMID:14729582 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
2-Amino-9H-pyrido[2,3-b]indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO 2-amino-9H-pyrido(2,3-b)indole results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP
ISO		 CYP1A1 protein results in increased metabolism of and results in increased activity of 2-amino-9H-pyrido(2,3-b)indole
2-amino-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA		 CTD PMID:1913651 PMID:27644595 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO
EXP		 [CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]; [furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 2-amino-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole
2-amino-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA		 CTD PMID:1913651 PMID:19243127 PMID:23898916 PMID:27644595 PMID:28160022 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-9H-pyrido(2,3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene] CTD PMID:19243127 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
affects response to substance		 ISO [CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole
NAT2 gene polymorphism affects the susceptibility to 2-amino-9H-pyrido(2,3-b)indole		 CTD PMID:19243127 PMID:28160022 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR gene mutant form results in decreased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole CTD PMID:26583703 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO 2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A2 protein
2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity		 ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein] CTD PMID:28629854 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole CTD PMID:28160022 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
3-Amino-1-methyl-5H-pyrido[4,3-b]indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alb albumin multiple interactions ISO MPO protein promotes the reaction [3-amino-1-methyl-5H-pyrido(4,3-b)indole binds to ALB protein] CTD PMID:6254679 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of CYP1A1 mRNA CTD PMID:27644595 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects response to substance
multiple interactions
increases expression
affects metabolic processing
increases activity		 ISO CYP1A2 protein affects the susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole
CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of CYP1A2 mRNA
CYP1A2 protein affects the metabolism of 3-amino-1-methyl-5H-pyrido(4,3-b)indole
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased activity of CYP1A2 protein		 CTD PMID:2655891 PMID:12744663 PMID:19140158 PMID:27644595 PMID:28160022 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Ddc dopa decarboxylase decreases activity ISO
EXP		 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of DDC protein CTD PMID:2243617 PMID:2904812 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased mutagenesis of HPRT1 gene CTD PMID:2335011 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein CTD PMID:3404091 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO MPO protein promotes the reaction [3-amino-1-methyl-5H-pyrido(4,3-b)indole binds to ALB protein] CTD PMID:6254679 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO NAT2 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole CTD PMID:28160022 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity		 ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin anthraquinone results in increased activity of POR protein]
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of POR protein		 CTD PMID:12744663 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions		 ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A1 protein
3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium]		 CTD PMID:30189235 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A2 protein
3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]		 CTD PMID:30189235 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity		 ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A3 protein		 CTD PMID:30189235 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions		 ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A8 protein
3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]		 CTD PMID:28629854 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A1 protein CTD PMID:30189235 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A2 protein CTD PMID:30189235 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole CTD PMID:28160022 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Th tyrosine hydroxylase decreases activity EXP 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TH protein CTD PMID:2904812 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tph1 tryptophan hydroxylase 1 decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TPH1 protein CTD PMID:1989631 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
annomontine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO annomontine results in increased expression of AHR mRNA CTD PMID:20449727 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO annomontine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO annomontine results in increased expression of CYP1A1 mRNA CTD PMID:20449727 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
beta-carboline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO norharman inhibits the reaction [Lipids metabolite results in increased activity of AHR protein]
norharman results in increased activity of AHR protein		 CTD PMID:27020609 PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression		 ISO norharman results in increased cleavage of CASP3 protein
norharman results in increased expression of CASP3 mRNA		 CTD PMID:35985368 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO norharman results in increased expression of CASP7 mRNA CTD PMID:35985368 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases expression ISO norharman results in increased expression of CASP9 mRNA CTD PMID:35985368 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity ISO norharman results in decreased activity of CAT protein CTD PMID:35985368 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO CYP1A1 protein affects the metabolism of [norharman co-treated with aniline]
norharman results in increased expression of CYP1A1 mRNA; norharman results in increased expression of CYP1A1 protein		 CTD PMID:15279827 PMID:28336214 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO norharman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity		 ISO norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
norharman results in decreased activity of MAOB protein		 CTD PMID:21554916 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO norharman results in increased expression of NFE2L2 protein CTD PMID:35985368 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO norharman results in increased expression of NQO1 mRNA CTD PMID:35985368 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO norharman results in increased cleavage of PARP1 protein CTD PMID:35985368 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A1 protein
norharman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A2 protein
norharman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A3 protein
norharman inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO norharman metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Evodiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of ABCB1 protein] CTD PMID:15710601 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO evodiamine inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]
evodiamine inhibits the reaction [INS1 results in increased phosphorylation of AKT1 protein]		 CTD PMID:15710601 PMID:17884939 PMID:20005289 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases cleavage		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased cleavage of BCL2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2 protein] CTD PMID:15710601 PMID:20005289 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15710601 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] CTD PMID:15710601 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15710601 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15710601 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:15710601 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased activity of and results in increased cleavage of CASP3 protein]; EUK-134 inhibits the reaction [evodiamine results in increased cleavage of CASP3 protein]; evodiamine results in increased activity of and results in increased cleavage of CASP3 protein; Rotenone inhibits the reaction [evodiamine results in increased cleavage of CASP3 protein] CTD PMID:20005289 PMID:34808100 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15710601 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15710601 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15710601 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO EUK-134 inhibits the reaction [evodiamine results in increased expression of DDIT3 protein] CTD PMID:34808100 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions
increases phosphorylation		 ISO Rotenone inhibits the reaction [evodiamine results in increased phosphorylation of DNM1L protein] CTD PMID:34808100 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation		 ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein] CTD PMID:19854188 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression
multiple interactions		 ISO evodiamine results in decreased expression of EIF2AK3 protein
EUK-134 inhibits the reaction [evodiamine results in decreased expression of EIF2AK3 protein]		 CTD PMID:34808100 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [evodiamine results in increased expression of FASLG protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased expression of FASLG protein]; wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] CTD PMID:20005289 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15710601 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein] CTD PMID:15710601 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO evodiamine inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of RELA protein] CTD PMID:15710601 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO evodiamine inhibits the reaction [INS1 results in increased phosphorylation of AKT1 protein] CTD PMID:17884939 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein] CTD PMID:17884939 PMID:19854188 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein] CTD PMID:17884939 PMID:19854188 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of MAPK8 protein modified form]
evodiamine inhibits the reaction [Bortezomib results in increased phosphorylation of MAPK8 protein]		 CTD PMID:23774672 PMID:38010754 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of MAPK9 protein modified form] CTD PMID:23774672 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15710601 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:15710601 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO evodiamine inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15710601 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein; wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:15710601 PMID:20005289 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17109845 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO EUK-134 inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein]; evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; Rotenone inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein] CTD PMID:15710601 PMID:34808100 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases phosphorylation		 ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein] CTD PMID:19854188 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO evodiamine results in decreased expression of PPARG CTD PMID:17884939 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases phosphorylation		 ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein] CTD PMID:19854188 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15710601 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO evodiamine inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of RELA protein]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; evodiamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; evodiamine inhibits the reaction [TNF protein affects the localization of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15710601 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO evodiamine inhibits the reaction [TNF protein affects the localization of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of CHUK protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of MYC protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein]; evodiamine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:15710601 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:15710601 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Harmaline results in increased expression of CDH1 protein CTD PMID:35963316 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein		 CTD PMID:22037238 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Eng endoglin decreases expression
multiple interactions		 ISO Harmaline results in decreased expression of ENG mRNA
Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA]		 CTD PMID:35963316 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Ifng interferon gamma increases secretion ISO Harmaline results in increased secretion of IFNG protein CTD PMID:35963316 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 affects secretion
multiple interactions		 ISO Harmaline affects the secretion of IL4 protein
Doxorubicin affects the reaction [Harmaline results in decreased secretion of IL4 protein]		 CTD PMID:35963316 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression		 ISO Doxorubicin promotes the reaction [Harmaline results in decreased expression of KDR mRNA] CTD PMID:35963316 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP
ISO		 Harmaline results in decreased activity of MAOA protein CTD PMID:15178694 PMID:24373881 PMID:28302559 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Harmaline results in decreased expression of MKI67 protein CTD PMID:35963316 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Harmaline results in decreased expression of MMP2 protein CTD PMID:35963316 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO Doxorubicin promotes the reaction [Harmaline results in decreased expression of PTGS2 mRNA] CTD PMID:35963316 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO Doxorubicin promotes the reaction [Harmaline results in decreased expression of VEGFA mRNA]
Harmaline results in decreased expression of VEGFA mRNA; Harmaline results in decreased expression of VEGFA protein		 CTD PMID:35963316 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity
increases expression		 ISO harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA		 CTD PMID:27590872 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity		 ISO [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein		 CTD PMID:22037238 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression		 ISO harman results in increased cleavage of CASP3 protein
harman results in increased expression of CASP3 mRNA		 CTD PMID:35985368 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO harman results in increased expression of CASP7 mRNA CTD PMID:35985368 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases expression ISO harman results in increased expression of CASP9 mRNA CTD PMID:35985368 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity ISO harman results in decreased activity of CAT protein CTD PMID:35985368 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 ISO
EXP		 AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein		 CTD PMID:20732341 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO harman results in increased expression of HMOX1 mRNA CTD PMID:35985368 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO harman results in increased expression of NFE2L2 protein CTD PMID:35985368 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO harman results in increased expression of NQO1 mRNA CTD PMID:35985368 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO harman results in increased cleavage of PARP1 protein CTD PMID:35985368 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity		 ISO harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein		 CTD PMID:30189235 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO harman results in decreased activity of SLC22A2 protein
harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Harmine results in decreased activity of ACHE protein CTD PMID:34078836 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Axin2 axin 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP harmine decreases expression of camk2d protein after myocardial infarction in rat heart left ventricle RGD PMID:26067684 RGD:11097969 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation EXP Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B decreases expression ISO Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions
increases phosphorylation		 ISO AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter] CTD PMID:27805061 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions
increases expression		 ISO Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein		 CTD PMID:27805061 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein		 CTD PMID:22001777 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A multiple interactions
decreases expression
affects binding
decreases activity		 ISO
EXP		 Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
harmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein		 CTD
RGD		 PMID:21573099 PMID:25751815 PMID:26067684 RGD:11097969 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 increases expression ISO Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mafa MAF bZIP transcription factor A increases expression ISO Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr 7:107,432,292...107,435,084
Ensembl chr 7:107,433,605...107,434,690 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP
ISO		 Harmine results in decreased activity of MAOA protein CTD PMID:24373881 PMID:28302559 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 affects localization ISO Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 affects localization ISO Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 affects localization ISO Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 affects localization ISO Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pln phospholamban increases expression EXP harmine increases expression of Pln protein after myocardial infarction in rat heart left ventricle RGD PMID:26067684 RGD:11097969 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein		 CTD PMID:20519739 PMID:27805061 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO Harmine results in increased expression of PPARGC1A protein
Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]		 CTD PMID:27805061 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prdm16 PR/SET domain 16 increases expression
multiple interactions		 ISO Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]		 CTD PMID:27805061 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions		 ISO Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]		 CTD PMID:27805061 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
harmol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO harmol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [harmol results in decreased stability of CYP1A1 protein]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
harmol results in decreased activity of CYP1A1 protein		 CTD PMID:22001777 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions EXP
ISO		 Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol] CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
Rutecarpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases localization
increases expression
multiple interactions
affects binding		 ISO
EXP		 rutecarpine results in increased localization of AHR protein
rutecarpine results in increased expression of AHR mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased localization of AHR protein]; AHR affects the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; rutecarpine promotes the reaction [AHR protein binds to CYP1A1 promoter]; W 7 inhibits the reaction [rutecarpine results in increased localization of AHR protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine binds to AHR protein]; rutecarpine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; W 7 inhibits the reaction [rutecarpine binds to AHR protein]		 CTD PMID:19853001 PMID:20449727 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO rutecarpine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO rutecarpine results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO rutecarpine results in decreased expression of BMPR1B mRNA CTD PMID:25633564 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 decreases expression ISO rutecarpine results in decreased expression of BMPR2 mRNA CTD PMID:25633564 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I increases phosphorylation ISO rutecarpine results in increased phosphorylation of CAMK1 protein CTD PMID:19853001 NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; rutecarpine inhibits the reaction [Glucose results in increased activity of CASP3 protein]; rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]] CTD PMID:28025122 PMID:36928891 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
affects binding		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; AHR affects the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; capsazepine inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; capsazepine inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; rutecarpine promotes the reaction [AHR protein binds to CYP1A1 promoter]; rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein; W 7 inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; W 7 inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine binds to CYP1A1 promoter]; W 7 inhibits the reaction [rutecarpine binds to CYP1A1 promoter]		 CTD PMID:19853001 PMID:20449727 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases activity		 EXP
ISO		 rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]
rutecarpine analog binds to and results in decreased activity of CYP1A2 protein; rutecarpine binds to and results in decreased activity of CYP1A2 protein
rutecarpine results in increased activity of CYP1A2 protein		 CTD PMID:12852960 PMID:15720787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO rutecarpine analog binds to and results in decreased activity of CYP1B1 protein CTD PMID:12852960 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO rutecarpine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] CTD PMID:28025122 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression		 ISO rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
rutecarpine results in decreased expression of HAMP mRNA		 CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO rutecarpine results in decreased expression of HJV mRNA CTD PMID:25633564 NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B protein]]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B protein] CTD PMID:36928891 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 protein]]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 protein]; rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 PMID:36928891 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]]; rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein] CTD PMID:36928891 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO rutecarpine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17109845 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein] CTD PMID:28025122 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein]]; rutecarpine inhibits the reaction [Glucose results in increased expression of TNF mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein] CTD PMID:36928891 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
tubastatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule decreases expression ISO tubastatin A results in decreased expression of CD274 protein CTD PMID:26775640 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions
decreases activity		 ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HDAC6 protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of HDAC6 protein]
tubastatin A results in decreased activity of HDAC6 protein		 CTD PMID:26775640 PMID:34910997 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of MYC protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of MYC protein] CTD PMID:34910997 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO tubastatin A inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:22367689 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO tubastatin A affects the reaction [PDK1 protein affects the abundance of Cyclic AMP] CTD PMID:28887310 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO tubastatin A results in increased expression of PTEN mRNA
[bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with tubastatin A] results in increased expression of PTEN mRNA		 CTD PMID:34910997 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO tubastatin A results in decreased phosphorylation of STAT3 protein CTD PMID:26775640 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  pyridoindole 136
                    (14E)-11-Hydroxy-14-(1H-imidazol-5-ylmethylidene)-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                    14-epi-isochaetominine C 0
                    2,11-dimethoxy-9-(2-methylbut-3-en-2-yl)-14-propan-2-yl-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                    2-Amino-3-methyl-9H-pyrido[2,3-b]indole 10
                    2-Amino-9H-pyrido[2,3-b]indole 10
                    2-amino-9-ethyl-3-pyrido[2,3-b]indolecarboxylic acid ethyl ester 0
                    3-Amino-1-methyl-5H-pyrido[4,3-b]indole 20
                    5H-Pyrido[4,3-b]indole 0
                    9H-Pyrido[2,3-b]indole 0
                    Aniquinazoline D 0
                    Commnesin 470 0
                    Communesin A 0
                    Communesin B 0
                    Communesin C 0
                    Communesin D 0
                    Communesin E 0
                    Communesin F 0
                    Communesin G 0
                    Communesin H 0
                    Communesin I 0
                    Communesin J 0
                    Communesin K 0
                    Epi-neoxaline 0
                    Isochaetominine 0
                    Isochaetominine A 0
                    Isochaetominine B 0
                    Isochaetominine C 0
                    Isopropylchaetominine 0
                    Meleagrin C 0
                    Meleagrin D 0
                    Meleagrin E 0
                    Mescengricin 0
                    Neosartin C 0
                    Neoxaline 0
                    Sphecoline A 0
                    Sphecoline E 0
                    Sphecoline F 0
                    Sphecoline G 0
                    Trp-P-1 0
                    Versiquinazoline H 0
                    Versiquinazoline J 0
                    Versiquinazoline K 0
                    Versiquinazoline Q 0
                    alosetron + 0
                    beta-carbolines + 117
                    intoplicine 0
                    latrepirdine 0
                    pyridoindolecarboxamide + 0
                    tubastatin A 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      pyridoindole 136
                                        (14E)-11-Hydroxy-14-(1H-imidazol-5-ylmethylidene)-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                                        14-epi-isochaetominine C 0
                                        2,11-dimethoxy-9-(2-methylbut-3-en-2-yl)-14-propan-2-yl-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                                        2-Amino-3-methyl-9H-pyrido[2,3-b]indole 10
                                        2-Amino-9H-pyrido[2,3-b]indole 10
                                        2-amino-9-ethyl-3-pyrido[2,3-b]indolecarboxylic acid ethyl ester 0
                                        3-Amino-1-methyl-5H-pyrido[4,3-b]indole 20
                                        5H-Pyrido[4,3-b]indole 0
                                        9H-Pyrido[2,3-b]indole 0
                                        Aniquinazoline D 0
                                        Commnesin 470 0
                                        Communesin A 0
                                        Communesin B 0
                                        Communesin C 0
                                        Communesin D 0
                                        Communesin E 0
                                        Communesin F 0
                                        Communesin G 0
                                        Communesin H 0
                                        Communesin I 0
                                        Communesin J 0
                                        Communesin K 0
                                        Epi-neoxaline 0
                                        Isochaetominine 0
                                        Isochaetominine A 0
                                        Isochaetominine B 0
                                        Isochaetominine C 0
                                        Isopropylchaetominine 0
                                        Meleagrin C 0
                                        Meleagrin D 0
                                        Meleagrin E 0
                                        Mescengricin 0
                                        Neosartin C 0
                                        Neoxaline 0
                                        Sphecoline A 0
                                        Sphecoline E 0
                                        Sphecoline F 0
                                        Sphecoline G 0
                                        Trp-P-1 0
                                        Versiquinazoline H 0
                                        Versiquinazoline J 0
                                        Versiquinazoline K 0
                                        Versiquinazoline Q 0
                                        alosetron + 0
                                        beta-carbolines + 117
                                        intoplicine 0
                                        latrepirdine 0
                                        pyridoindolecarboxamide + 0
                                        tubastatin A 7
paths to the root