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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridoindole
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Accession:CHEBI:48888 term browser browse the term
Synonyms:related_synonym: pyridoindoles


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2-Amino-3-methyl-9H-pyrido[2,3-b]indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions 		EXP
ISO 		2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA; 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein
lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein] 		CTD PMID:8902619 PMID:27644595 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions 		EXP
ISO 		2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA; 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein
lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]
CYP1A2 protein results in increased activity of and results in increased hydroxylation of 2-amino-3-methyl-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole 		CTD PMID:8902619 PMID:14729582 PMID:27644595 PMID:28160022 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Ddc dopa decarboxylase decreases activity ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in decreased activity of DDC protein CTD PMID:2243617 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Nat2 N-acetyltransferase 2 increases activity
multiple interactions 		ISO NAT2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole
NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole 		CTD PMID:14729582 PMID:28160022 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity 		ISO 2-amino-3-methyl-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3-methyl-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A2 protein 		CTD PMID:30189235 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SULT1A1 protein results in increased activity of and results in increased sulfation of 2-amino-3-methyl-9H-pyrido(2,3-b)indole; SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole CTD PMID:14729582 PMID:28160022 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases activity ISO SULT1B1 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole CTD PMID:14729582 NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,771,868...20,785,549 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A increases activity ISO SULT1C2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole CTD PMID:14729582 NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132 		JBrowse link
2-Amino-9H-pyrido[2,3-b]indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO 2-amino-9H-pyrido(2,3-b)indole results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		EXP
ISO 		CYP1A1 protein results in increased metabolism of and results in increased activity of 2-amino-9H-pyrido(2,3-b)indole
2-amino-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA 		CTD PMID:1913651 PMID:27644595 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression 		ISO
EXP 		[CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]; [furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 2-amino-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased activity of 2-amino-9H-pyrido(2,3-b)indole; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole
2-amino-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA 		CTD PMID:1913651 PMID:19243127 PMID:23898916 PMID:27644595 PMID:28160022 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-9H-pyrido(2,3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene] CTD PMID:19243127 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:137,655,680...137,687,712 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
affects response to substance 		ISO [CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole
NAT2 gene polymorphism affects the susceptibility to 2-amino-9H-pyrido(2,3-b)indole 		CTD PMID:19243127 PMID:28160022 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR gene mutant form results in decreased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole CTD PMID:26583703 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions 		ISO 2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A2 protein
2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] 		CTD PMID:30189235 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity 		ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein] CTD PMID:28629854 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole CTD PMID:28160022 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
3-Amino-1-methyl-5H-pyrido[4,3-b]indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of AHR protein CTD PMID:27644595 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Alb albumin multiple interactions ISO MPO protein promotes the reaction [3-amino-1-methyl-5H-pyrido(4,3-b)indole binds to ALB protein] CTD PMID:6254679 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of CYP1A1 mRNA CTD PMID:27644595 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects response to substance
multiple interactions
increases expression
affects metabolic processing
increases activity 		ISO CYP1A2 protein affects the susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole
CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of CYP1A2 mRNA
CYP1A2 protein affects the metabolism of 3-amino-1-methyl-5H-pyrido(4,3-b)indole
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased activity of CYP1A2 protein 		CTD PMID:2655891 PMID:12744663 PMID:19140158 PMID:27644595 PMID:28160022 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Ddc dopa decarboxylase decreases activity ISO
EXP 		3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of DDC protein CTD PMID:2243617 PMID:2904812 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased mutagenesis of HPRT1 gene CTD PMID:2335011 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:137,655,680...137,687,712 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein CTD PMID:3404091 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO MPO protein promotes the reaction [3-amino-1-methyl-5H-pyrido(4,3-b)indole binds to ALB protein] CTD PMID:6254679 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO NAT2 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole CTD PMID:28160022 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity 		ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin anthraquinone results in increased activity of POR protein]
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of POR protein 		CTD PMID:12744663 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions 		ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A1 protein
3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] 		CTD PMID:30189235 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions 		ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A2 protein
3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium] 		CTD PMID:30189235 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity 		ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A3 protein 		CTD PMID:30189235 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions 		ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A8 protein
3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein] 		CTD PMID:28629854 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A1 protein CTD PMID:30189235 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A2 protein CTD PMID:30189235 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO SULT1A1 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole CTD PMID:28160022 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Th tyrosine hydroxylase decreases activity EXP 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TH protein CTD PMID:2904812 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Tph1 tryptophan hydroxylase 1 decreases activity ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TPH1 protein CTD PMID:1989631 NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:106,085,953...106,312,484 		JBrowse link
annomontine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO annomontine results in increased expression of AHR mRNA CTD PMID:20449727 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO annomontine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO annomontine results in increased expression of CYP1A1 mRNA CTD PMID:20449727 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
beta-carboline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity 		ISO norharman inhibits the reaction [Lipids metabolite results in increased activity of AHR protein]
norharman results in increased activity of AHR protein 		CTD PMID:27020609 PMID:28336214 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression 		ISO norharman results in increased cleavage of CASP3 protein
norharman results in increased expression of CASP3 mRNA 		CTD PMID:35985368 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases expression ISO norharman results in increased expression of CASP7 mRNA CTD PMID:35985368 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases expression ISO norharman results in increased expression of CASP9 mRNA CTD PMID:35985368 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase decreases activity ISO norharman results in decreased activity of CAT protein CTD PMID:35985368 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		ISO CYP1A1 protein affects the metabolism of [norharman co-treated with aniline]
norharman results in increased expression of CYP1A1 mRNA; norharman results in increased expression of CYP1A1 protein 		CTD PMID:15279827 PMID:28336214 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO norharman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity 		ISO norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
norharman results in decreased activity of MAOB protein 		CTD PMID:21554916 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO norharman results in increased expression of NFE2L2 protein CTD PMID:35985368 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO norharman results in increased expression of NQO1 mRNA CTD PMID:35985368 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO norharman results in increased cleavage of PARP1 protein CTD PMID:35985368 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions 		ISO norharman results in decreased activity of SLC22A1 protein
norharman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] 		CTD PMID:30189235 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions 		ISO norharman results in decreased activity of SLC22A2 protein
norharman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] 		CTD PMID:30189235 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions 		ISO norharman results in decreased activity of SLC22A3 protein
norharman inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] 		CTD PMID:30189235 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO norharman metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Evodiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aarsd1 alanyl-tRNA synthetase domain containing 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of AARSD1 protein] CTD PMID:35362542 NCBI chr10:86,840,874...86,854,077
Ensembl chr10:86,840,874...86,849,734 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of ABCB1 protein] CTD PMID:15710601 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO evodiamine inhibits the reaction [Dietary Fats results in decreased expression of ABCG1 mRNA]; evodiamine inhibits the reaction [Dietary Fats results in decreased expression of ABCG1 protein] CTD PMID:34902249 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO evodiamine inhibits the reaction [Dietary Fats results in increased expression of ABCG8 protein] CTD PMID:34902249 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Abraxas2 abraxas 2, BRISC complex subunit multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ABRAXAS2 protein] CTD PMID:35362542 NCBI chr 1:197,077,177...197,102,753
Ensembl chr 1:197,077,158...197,102,757 		JBrowse link
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ACAP2 protein] CTD PMID:35362542 NCBI chr11:83,043,442...83,159,105
Ensembl chr11:83,043,511...83,159,107 		JBrowse link
G Acp6 acid phosphatase 6, lysophosphatidic multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ACP6 protein] CTD PMID:35362542 NCBI chr 2:187,400,786...187,421,877
Ensembl chr 2:187,349,186...187,422,743 		JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ACSM3 protein] CTD PMID:35362542 NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ACSS2 protein] CTD PMID:35362542 NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO 		evodiamine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:28303407 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Actb actin, beta decreases expression ISO evodiamine results in decreased expression of ACTB mRNA CTD PMID:32057900 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242 		JBrowse link
G Actg1 actin, gamma 1 increases expression ISO evodiamine results in increased expression of ACTG1 mRNA CTD PMID:32057900 NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ADAM10 protein] CTD PMID:35362542 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600 		JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of AIP protein] CTD PMID:35362542 NCBI chr 1:210,837,473...210,848,691
Ensembl chr 1:210,836,755...210,848,634 		JBrowse link
G Akap12 A-kinase anchoring protein 12 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of AKAP12 protein] CTD PMID:35362542 NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:43,199,008...43,225,557 		JBrowse link
G Akap8 A-kinase anchoring protein 8 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of AKAP8 protein] CTD PMID:35362542 NCBI chr 7:11,966,769...11,983,056
Ensembl chr 7:11,966,772...11,982,900 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
decreases phosphorylation 		ISO
EXP 		evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; evodiamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]
evodiamine results in decreased expression of AKT1 mRNA
evodiamine inhibits the reaction [INS1 results in increased phosphorylation of AKT1 protein]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] 		CTD PMID:15710601 PMID:17884939 PMID:20005289 PMID:28303407 PMID:34401976 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ALDOC protein] CTD PMID:35362542 NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133 		JBrowse link
G Amot angiomotin decreases expression ISO evodiamine results in decreased expression of AMOT mRNA CTD PMID:32057900 NCBI chr  X:113,778,990...113,837,846
Ensembl chr  X:113,781,526...113,837,482 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of AMPD3 protein] CTD PMID:35362542 NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:174,294,867...174,364,608 		JBrowse link
G Ano10 anoctamin 10 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ANO10 protein] CTD PMID:35362542 NCBI chr 8:130,719,177...130,838,243
Ensembl chr 8:130,718,755...130,877,636 		JBrowse link
G Ap3m1 adaptor related protein complex 3 subunit mu 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of AP3M1 protein] CTD PMID:35362542 NCBI chr15:3,285,591...3,314,139
Ensembl chr15:3,295,444...3,313,104 		JBrowse link
G Apc APC regulator of WNT signaling pathway affects response to substance
multiple interactions 		ISO APC protein mutant form affects the susceptibility to evodiamine
[APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL15 protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL17A protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL1B protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL2 protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL22 protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL6 protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of S100A9 protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of TNF protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the phosphorylation of NFKBIA protein; [APC protein mutant form affects the susceptibility to evodiamine] which affects the phosphorylation of RELA protein 		CTD PMID:35362542 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of APOE protein] CTD PMID:35362542 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of APPL2 protein] CTD PMID:35362542 NCBI chr 7:22,019,480...22,072,386
Ensembl chr 7:22,022,963...22,072,385 		JBrowse link
G Ar androgen receptor multiple interactions ISO evodiamine inhibits the reaction [Dihydrotestosterone promotes the reaction [SRC protein binds to AR protein]] CTD PMID:34713388 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Arfgap2 ARF GTPase activating protein 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ARFGAP2 protein] CTD PMID:35362542 NCBI chr 3:97,692,105...97,704,246
Ensembl chr 3:97,692,110...97,704,247 		JBrowse link
G Arl3 ARF like GTPase 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ARL3 protein] CTD PMID:35362542 NCBI chr 1:255,342,078...255,388,087
Ensembl chr 1:255,342,076...255,388,279 		JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ARPC5 protein] CTD PMID:35362542 NCBI chr13:67,454,379...67,463,288
Ensembl chr13:67,437,027...67,463,283 		JBrowse link
G Atp5mf ATP synthase membrane subunit f multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ATP5MF protein] CTD PMID:35362542 NCBI chr12:14,535,435...14,542,007
Ensembl chr12:14,522,832...14,542,709 		JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ATP6V0C protein] CTD PMID:35362542 NCBI chr10:13,700,764...13,707,147
Ensembl chr10:13,700,764...13,706,245 		JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ATP6V0D1 protein] CTD PMID:35362542 NCBI chr19:50,313,268...50,357,248
Ensembl chr19:50,313,273...50,357,395 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ATP6V1F protein] CTD PMID:35362542 NCBI chr 4:59,033,020...59,035,980 JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO evodiamine results in increased expression of AXL mRNA CTD PMID:32057900 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009 		JBrowse link
G B3gnt7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of B3GNT7 protein] CTD PMID:35362542 NCBI chr 9:94,404,197...94,408,148
Ensembl chr 9:94,404,135...94,408,147 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO evodiamine results in increased expression of BAD protein CTD PMID:32425601 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Banf1 barrier to autointegration nuclear assembly factor 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of BANF1 protein] CTD PMID:35362542 NCBI chr 1:212,101,523...212,103,568
Ensembl chr 1:212,101,523...212,103,552 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of BAX protein]; 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [evodiamine results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of BAX protein]
evodiamine results in increased expression of BAX mRNA; evodiamine results in increased expression of BAX protein 		CTD PMID:32057900 PMID:32425601 PMID:34824590 PMID:35899176 PMID:38878560 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases cleavage 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased cleavage of BCL2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of BCL2 protein]
evodiamine results in decreased expression of BCL2 mRNA; evodiamine results in decreased expression of BCL2 protein 		CTD PMID:15710601 PMID:20005289 PMID:32057900 PMID:32183146 PMID:32425601 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15710601 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of BCL2L1 protein] CTD PMID:15710601 PMID:32183146 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO evodiamine results in increased expression of BDNF mRNA CTD PMID:38878560 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Becn1 beclin 1 increases expression ISO evodiamine results in increased expression of BECN1 mRNA; evodiamine results in increased expression of BECN1 protein CTD PMID:34824590 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15710601 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15710601 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of BIRC5 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of BIRC5 protein]
evodiamine results in decreased expression of BIRC5 mRNA; evodiamine results in decreased expression of BIRC5 protein 		CTD PMID:15710601 PMID:32057900 PMID:32183146 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of BPNT2 protein] CTD PMID:35362542 NCBI chr 5:22,573,241...22,600,126
Ensembl chr 5:22,570,165...22,600,126 		JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of BRK1 protein] CTD PMID:35362542 NCBI chr 4:148,306,436...148,321,668
Ensembl chr 4:148,306,398...148,321,984 		JBrowse link
G C3 complement C3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of C3 protein] CTD PMID:35362542 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Ca1 carbonic anhydrase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CAR1 protein] CTD PMID:35362542 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of CALCA mRNA]; evodiamine inhibits the reaction [Imiquimod results in increased expression of CALCA protein] CTD PMID:38948922 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of CASK protein] CTD PMID:35362542 NCBI chr  X:11,572,328...11,915,831
Ensembl chr  X:11,572,636...11,911,948 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP evodiamine inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of CASP1 protein] CTD PMID:37555854 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage 		ISO [HGF protein co-treated with evodiamine] results in increased cleavage of CASP3 protein; [tetramethylpyrazine co-treated with evodiamine] results in increased activity of CASP3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased activity of and results in increased cleavage of CASP3 protein]; EUK-134 inhibits the reaction [evodiamine results in increased cleavage of CASP3 protein]; evodiamine results in increased activity of and results in increased cleavage of CASP3 protein; evodiamine results in increased expression of and results in increased cleavage of CASP3 protein; Rotenone inhibits the reaction [evodiamine results in increased cleavage of CASP3 protein]
evodiamine results in increased expression of CASP3 mRNA; evodiamine results in increased expression of CASP3 protein 		CTD PMID:20005289 PMID:32057900 PMID:32183146 PMID:32425601 PMID:34808100 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases expression ISO evodiamine results in increased expression of CASP8 mRNA; evodiamine results in increased expression of CASP8 protein CTD PMID:34824590 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO evodiamine results in increased cleavage of CASP9 protein CTD PMID:35899176 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression 		EXP
ISO 		evodiamine inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
evodiamine results in decreased expression of CCN2 protein
XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of CCN2 protein] 		CTD PMID:28303407 PMID:32057900 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO evodiamine results in increased expression of CCNB1 protein CTD PMID:35899176 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression 		ISO evodiamine inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
evodiamine results in decreased expression of CCND1 protein
evodiamine results in increased expression of CCND1 mRNA 		CTD PMID:15710601 PMID:32183146 PMID:32425601 PMID:38878560 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO evodiamine results in decreased expression of CCNE2 mRNA CTD PMID:32057900 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Cd274 CD274 molecule decreases expression
multiple interactions 		ISO evodiamine results in decreased expression of CD274 mRNA; evodiamine results in decreased expression of CD274 protein
evodiamine inhibits the reaction [IFNG protein results in increased expression of CD274 mRNA]; evodiamine inhibits the reaction [Lactic Acid results in increased expression of CD274 mRNA]; evodiamine inhibits the reaction [Lactic Acid results in increased expression of CD274 protein] 		CTD PMID:33208183 PMID:37611839 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Cd34 CD34 molecule multiple interactions ISO evodiamine inhibits the reaction [TGFB1 protein results in decreased expression of CD34 protein] CTD PMID:28303407 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CD68 protein] CTD PMID:35362542 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cd74 CD74 molecule multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CD74 protein] CTD PMID:35362542 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Cdc25c cell division cycle 25C decreases phosphorylation ISO evodiamine results in decreased phosphorylation of CDC25C protein CTD PMID:35899176 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO evodiamine results in increased expression of CDH1 protein CTD PMID:32425601 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO evodiamine results in decreased expression of CDH2 protein CTD PMID:32425601 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases phosphorylation ISO evodiamine results in increased phosphorylation of CDK1 protein CTD PMID:35899176 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cds2 CDP-diacylglycerol synthase 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CDS2 protein] CTD PMID:35362542 NCBI chr 3:139,967,870...140,006,459
Ensembl chr 3:139,967,742...140,009,201 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15710601 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Chga chromogranin A multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CHGA protein] CTD PMID:35362542 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:127,460,854...127,472,237 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of CHORDC1 protein] CTD PMID:35362542 NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696 		JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CHP1 protein] CTD PMID:35362542 NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:126,989,579...127,042,443 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15710601 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of CISD1 protein] CTD PMID:35362542 NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042 		JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of CLPP protein] CTD PMID:35362542 NCBI chr 9:1,917,305...1,924,706
Ensembl chr 9:1,918,682...1,924,705 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP evodiamine inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 protein] CTD PMID:28303407 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP evodiamine inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein] CTD PMID:28303407 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Col4a4 collagen type IV alpha 4 chain decreases expression ISO evodiamine results in decreased expression of COL4A4 mRNA CTD PMID:38878560 NCBI chr 9:91,281,324...91,323,577
Ensembl chr 9:91,203,670...91,323,577 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of COL6A1 protein] CTD PMID:35362542 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of COL6A2 protein] CTD PMID:35362542 NCBI chr20:12,021,182...12,048,932
Ensembl chr20:12,021,265...12,057,042 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of COL6A3 protein] CTD PMID:35362542 NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:98,809,171...98,886,990 		JBrowse link
G Colgalt1 collagen beta(1-O)galactosyltransferase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of COLGALT1 protein] CTD PMID:35362542 NCBI chr16:18,353,779...18,366,087
Ensembl chr16:18,353,570...18,366,086 		JBrowse link
G Copz1 COPI coat complex subunit zeta 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of COPZ1 protein] CTD PMID:35362542 NCBI chr 7:136,287,696...136,314,131
Ensembl chr 7:136,288,032...136,314,135 		JBrowse link
G Coq6 coenzyme Q6 monooxygenase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of COQ6 protein] CTD PMID:35362542 NCBI chr 6:109,738,934...109,750,315
Ensembl chr 6:109,738,951...109,750,310 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of COX17 protein] CTD PMID:35362542 NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of COX7A2 protein] CTD PMID:35362542 NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:55,514,261...55,514,512
Ensembl chr 8:55,514,261...55,514,512 		JBrowse link
G Cpne1 copine 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CPNE1 protein] CTD PMID:35362542 NCBI chr 3:165,047,615...165,089,994 JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of CSNK1A1 protein] CTD PMID:35362542 NCBI chr18:57,285,156...57,320,540
Ensembl chr18:57,287,412...57,320,538 		JBrowse link
G Csnk1d casein kinase 1, delta increases expression ISO evodiamine results in increased expression of CSNK1D mRNA CTD PMID:32057900 NCBI chr10:106,713,497...106,754,953
Ensembl chr10:106,694,279...106,754,953 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of CTH protein] CTD PMID:35362542 NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO evodiamine results in decreased expression of CTNNB1 protein CTD PMID:32425601 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsc cathepsin C multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CTSC protein] CTD PMID:35362542 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082 		JBrowse link
G Cygb cytoglobin multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of CYGB protein] CTD PMID:35362542 NCBI chr10:102,376,506...102,386,272
Ensembl chr10:102,376,507...102,386,272 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO evodiamine analog results in increased expression of CYP1B1 mRNA; evodiamine results in increased expression of CYP1B1 mRNA CTD PMID:34955744 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Dapk3 death-associated protein kinase 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of DAPK3 protein] CTD PMID:35362542 NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272 		JBrowse link
G Dctn3 dynactin subunit 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of DCTN3 protein] CTD PMID:35362542 NCBI chr 5:61,676,950...61,684,958
Ensembl chr 5:61,676,950...61,684,903 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		ISO EUK-134 inhibits the reaction [evodiamine results in increased expression of DDIT3 protein] CTD PMID:34808100 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddx23 DEAD-box helicase 23 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of DDX23 protein] CTD PMID:35362542 NCBI chr 7:131,676,636...131,693,917
Ensembl chr 7:131,676,636...131,689,074 		JBrowse link
G Dhdh dihydrodiol dehydrogenase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of DHDH protein] CTD PMID:35362542 NCBI chr 1:105,088,108...105,102,560
Ensembl chr 1:105,090,309...105,101,567 		JBrowse link
G Dhodh dihydroorotate dehydrogenase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of DHODH protein] CTD PMID:35362542 NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496 		JBrowse link
G Diaph1 diaphanous-related formin 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of DIAPH1 protein] CTD PMID:35362542 NCBI chr18:29,920,889...30,020,280
Ensembl chr18:29,920,889...30,020,280 		JBrowse link
G Diaph2 diaphanous-related formin 2 decreases expression ISO evodiamine results in decreased expression of DIAPH2 mRNA CTD PMID:32057900 NCBI chr  X:96,700,535...97,528,080
Ensembl chr  X:96,700,726...97,528,080 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of DNAJB4 protein] CTD PMID:35362542 NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions
increases phosphorylation 		ISO Rotenone inhibits the reaction [evodiamine results in increased phosphorylation of DNM1L protein] CTD PMID:34808100 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420 		JBrowse link
G Dock1 dedicator of cyto-kinesis 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of DOCK1 protein] CTD PMID:35362542 NCBI chr 1:198,897,021...199,413,636
Ensembl chr 1:198,897,045...199,413,627 		JBrowse link
G Ecpas Ecm29 proteasome adaptor and scaffold multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ECPAS protein] CTD PMID:35362542 NCBI chr 5:78,398,449...78,509,077
Ensembl chr 5:78,398,718...78,512,908 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO evodiamine results in decreased expression of EFNA1 mRNA CTD PMID:38878560 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [EGF protein results in increased expression of XIAP protein]
evodiamine results in decreased expression of EGF mRNA; evodiamine results in decreased expression of EGF protein 		CTD PMID:34824590 PMID:39334374 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
increases phosphorylation 		ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein]
evodiamine results in decreased expression of EGFR mRNA; evodiamine results in decreased expression of EGFR protein 		CTD PMID:19854188 PMID:34824590 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression
multiple interactions 		ISO evodiamine results in decreased expression of EIF2AK3 protein
EUK-134 inhibits the reaction [evodiamine results in decreased expression of EIF2AK3 protein] 		CTD PMID:34808100 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of EIF2B5 protein] CTD PMID:35362542 NCBI chr11:93,898,814...93,909,431
Ensembl chr11:93,898,814...93,908,800 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B decreases expression ISO evodiamine results in decreased expression of EIF4B mRNA CTD PMID:38878560 NCBI chr 7:135,085,259...135,107,054
Ensembl chr 7:135,085,066...135,107,064 		JBrowse link
G Eno2 enolase 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ENO2 protein] CTD PMID:35362542 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220 		JBrowse link
G Epha2 Eph receptor A2 increases expression ISO evodiamine results in increased expression of EPHA2 mRNA CTD PMID:38878560 NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO evodiamine results in decreased expression of ERBB2 protein CTD PMID:39334374 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ERMP1 protein] CTD PMID:35362542 NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:236,801,466...236,839,197 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ERO1A protein] CTD PMID:35362542 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of ESR2 mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of ESR2 protein; [evodiamine co-treated with tetramethylpyrazine] results in increased methylation of ESR2 promoter; [tetramethylpyrazine co-treated with evodiamine] inhibits the reaction [POU5F1 protein binds to ESR2 promoter] CTD PMID:39486648 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F11r F11 receptor multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of F11R protein] CTD PMID:35362542 NCBI chr13:86,406,229...86,429,819
Ensembl chr13:86,406,218...86,429,816 		JBrowse link
G Fabp5 fatty acid binding protein 5 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of FABP5 protein] CTD PMID:35362542 NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127 		JBrowse link
G Fam136a family with sequence similarity 136, member A multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of FAM136A protein] CTD PMID:35362542 NCBI chr 4:120,362,563...120,368,479
Ensembl chr 4:120,362,561...120,368,479 		JBrowse link
G Fam234a family with sequence similarity 234, member A multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of FAM234A protein] CTD PMID:35362542 NCBI chr10:15,736,741...15,768,043
Ensembl chr10:15,736,742...15,749,835 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [evodiamine results in increased expression of FASLG protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased expression of FASLG protein]; wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] CTD PMID:20005289 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO evodiamine results in increased expression of FAT1 mRNA CTD PMID:32057900 NCBI chr16:53,909,759...54,029,175
Ensembl chr16:53,909,556...54,028,609 		JBrowse link
G Fblim1 filamin binding LIM protein 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of FBLIM1 protein] CTD PMID:35362542 NCBI chr 5:159,167,004...159,198,578
Ensembl chr 5:159,167,004...159,196,853 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of FBN1 protein] CTD PMID:35362542 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283 		JBrowse link
G Fdx1 ferredoxin 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of FDX1 protein] CTD PMID:35362542 NCBI chr 8:61,164,839...61,183,645
Ensembl chr 8:61,164,839...61,183,583 		JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of FGA protein] CTD PMID:35362542 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO evodiamine results in increased expression of FGF1 mRNA CTD PMID:32057900 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO evodiamine results in decreased expression of FGFR2 mRNA CTD PMID:38878560 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO evodiamine results in increased expression of FGFR3 mRNA CTD PMID:31835579 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209 		JBrowse link
G Fjx1 four-jointed box kinase 1 decreases expression ISO evodiamine results in decreased expression of FJX1 mRNA CTD PMID:32057900 NCBI chr 3:109,229,223...109,231,324
Ensembl chr 3:109,227,170...109,232,479 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP evodiamine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:28303407 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP evodiamine inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA] CTD PMID:32147481 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of FUCA1 protein] CTD PMID:35362542 NCBI chr 5:153,436,262...153,453,512
Ensembl chr 5:153,436,248...153,453,511 		JBrowse link
G Fzd9 frizzled class receptor 9 increases expression ISO evodiamine results in increased expression of FZD9 mRNA CTD PMID:31835579 NCBI chr12:27,063,640...27,065,954
Ensembl chr12:27,063,415...27,074,485 		JBrowse link
G Galk1 galactokinase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GALK1 protein] CTD PMID:35362542 NCBI chr10:101,742,067...101,746,244
Ensembl chr10:101,735,061...101,746,258 		JBrowse link
G Galnt1 polypeptide N-acetylgalactosaminyltransferase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GALNT1 protein] CTD PMID:35362542 NCBI chr18:15,763,697...15,843,598
Ensembl chr18:15,764,277...15,843,588 		JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of GALNT3 protein] CTD PMID:35362542 NCBI chr 3:71,150,559...71,187,321
Ensembl chr 3:71,150,571...71,174,323 		JBrowse link
G Gbp4 guanylate binding protein 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of GBP4 protein] CTD PMID:35362542 NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:233,978,486...233,992,120 		JBrowse link
G Gbp7 guanylate binding protein 7 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of GBP7 protein] CTD PMID:35362542 NCBI chr 2:233,948,774...233,970,532
Ensembl chr 2:233,948,677...233,970,526 		JBrowse link
G Gda guanine deaminase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of GDA protein] CTD PMID:35362542 NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348 		JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GDPD1 protein] CTD PMID:35362542 NCBI chr10:72,318,716...72,381,143
Ensembl chr10:72,337,778...72,381,120 		JBrowse link
G Ggh gamma-glutamyl hydrolase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GGH protein] CTD PMID:35362542 NCBI chr 5:38,326,747...38,349,655
Ensembl chr 5:38,326,594...38,349,647 		JBrowse link
G Gipc2 GIPC PDZ domain containing family, member 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GIPC2 protein] CTD PMID:35362542 NCBI chr 2:243,690,742...243,770,199
Ensembl chr 2:243,690,748...243,770,199 		JBrowse link
G Gli1 GLI family zinc finger 1 increases expression ISO evodiamine results in increased expression of GLI1 mRNA CTD PMID:31835579 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540 		JBrowse link
G Glrx5 glutaredoxin 5 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GLRX5 protein] CTD PMID:35362542 NCBI chr 6:129,752,902...129,763,278
Ensembl chr 6:129,752,840...129,763,278 		JBrowse link
G Gmpr guanosine monophosphate reductase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GMPR protein] CTD PMID:35362542 NCBI chr17:19,357,992...19,395,807
Ensembl chr17:19,357,992...19,431,655 		JBrowse link
G Gnao1 G protein subunit alpha o1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GNAO1 protein] CTD PMID:35362542 NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,040,788...11,198,437 		JBrowse link
G Gng12 G protein subunit gamma 12 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of GNG12 protein] CTD PMID:35362542 NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476 		JBrowse link
G Golga3 golgin A3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GOLGA3 protein] CTD PMID:35362542 NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226 		JBrowse link
G Golga4 golgin A4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GOLGA4 protein] CTD PMID:35362542 NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603 		JBrowse link
G Gpc5 glypican 5 increases expression ISO evodiamine results in increased expression of GPC5 mRNA CTD PMID:32057900 NCBI chr15:98,614,499...100,051,285
Ensembl chr15:98,646,340...100,051,514 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:34218553 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GPX2 protein] CTD PMID:35362542 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions 		ISO evodiamine results in decreased expression of GPX4 protein
evodiamine inhibits the reaction [Lactic Acid results in increased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [evodiamine results in decreased expression of GPX4 protein] 		CTD PMID:37611839 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP evodiamine inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of GRIA1 protein] CTD PMID:32147481 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression ISO evodiamine results in increased expression of GSK3B protein CTD PMID:32425601 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GSTK1 protein] CTD PMID:35362542 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GSTM3 protein] CTD PMID:35362542 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Guk1 guanylate kinase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GUK1 protein] CTD PMID:35362542 NCBI chr10:44,471,075...44,488,332
Ensembl chr10:44,471,085...44,479,355 		JBrowse link
G Gyg1 glycogenin 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of GYG1 protein] CTD PMID:35362542 NCBI chr 2:104,540,927...104,583,038
Ensembl chr 2:104,540,533...104,582,818 		JBrowse link
G H1f1 H1.1 linker histone, cluster member multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of H1F1 protein] CTD PMID:35362542 NCBI chr17:41,762,278...41,794,876 JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [tetramethylpyrazine co-treated with evodiamine] results in increased expression of H2AX protein CTD PMID:39486648 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of H6PD protein] CTD PMID:35362542 NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125 		JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of HCLS1 protein] CTD PMID:35362542 NCBI chr11:77,322,873...77,346,333
Ensembl chr11:77,322,873...77,346,387 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 affects expression ISO evodiamine affects the expression of HES1 mRNA CTD PMID:31835579 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 increases expression ISO evodiamine results in increased expression of HES5 mRNA CTD PMID:31835579 NCBI chr 5:170,804,511...170,807,988
Ensembl chr 5:170,803,940...170,806,021 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [HGF protein co-treated with evodiamine] results in increased cleavage of CASP3 protein; [HGF protein co-treated with evodiamine] results in increased cleavage of PARP1 protein; evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of and affects the localization of STAT3 protein]; evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]; evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of SRC protein]; HGF protein affects the reaction [evodiamine results in decreased expression of BCL2L1 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of BIRC5 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of MMP9 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of PTGS2 protein]; MET protein affects the reaction [evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of SRC protein]]; MET protein affects the reaction [evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:32183146 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [Lactic Acid results in increased expression of HIF1A protein]
evodiamine results in decreased expression of HIF1A protein 		CTD PMID:37611839 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hint2 histidine triad nucleotide binding protein 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of HINT2 protein] CTD PMID:35362542 NCBI chr 5:62,700,383...62,702,638
Ensembl chr 5:62,700,384...62,702,915 		JBrowse link
G Hmgb3 high mobility group box 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of HMGB3 protein] CTD PMID:35362542 NCBI chr  X:154,341,106...154,346,087
Ensembl chr  X:154,340,935...154,346,097 		JBrowse link
G Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of HNRNPUL1 protein] CTD PMID:35362542 NCBI chr 1:90,356,182...90,391,923
Ensembl chr 1:90,356,182...90,390,370 		JBrowse link
G Hp haptoglobin multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of HP protein] CTD PMID:35362542 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO evodiamine results in increased expression of HSP90AA1 mRNA CTD PMID:38878560 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO evodiamine results in increased expression of HSP90AB1 mRNA CTD PMID:38878560 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15710601 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions ISO evodiamine inhibits the reaction [IFNG protein results in increased expression of CD274 mRNA] CTD PMID:33208183 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of IGF2R protein] CTD PMID:35362542 NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of IGFBP7 protein] CTD PMID:35362542 NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620 		JBrowse link
G Ik IK cytokine multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of IK protein] CTD PMID:35362542 NCBI chr18:28,632,025...28,646,829
Ensembl chr18:28,631,616...28,653,463 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein] CTD PMID:15710601 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il15 interleukin 15 multiple interactions ISO [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL15 protein CTD PMID:35362542 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL17A protein; evodiamine inhibits the reaction [Imiquimod results in increased expression of IL17A protein] CTD PMID:35362542 PMID:38948922 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP evodiamine inhibits the reaction [Uric Acid results in increased expression of IL18 protein] CTD PMID:37555854 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of IL1B mRNA; evodiamine inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of RELA protein]
evodiamine inhibits the reaction [Uric Acid results in increased expression of IL1B protein]
[APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL1B protein; evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] 		CTD PMID:15710601 PMID:34218553 PMID:34401976 PMID:35362542 PMID:37555854 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of IL1RN protein] CTD PMID:35362542 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL2 protein; evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of IL2 protein] CTD PMID:35362542 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of IL23A protein] CTD PMID:38948922 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of IL6 mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased secretion of IL6 protein; evodiamine inhibits the reaction [IL6 protein affects the localization of STAT3 protein]; evodiamine inhibits the reaction [IL6 protein results in increased phosphorylation of RELA protein]; evodiamine inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
[APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of IL6 protein; evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein] 		CTD PMID:33277208 PMID:34218553 PMID:35362542 PMID:39486648 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO evodiamine inhibits the reaction [INS1 results in increased phosphorylation of AKT1 protein] CTD PMID:17884939 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ITIH4 protein] CTD PMID:35362542 NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160 		JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of KDM1A protein] CTD PMID:35362542 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:154,065,543...154,121,775 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO evodiamine inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:34713388 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of LAMP2 protein] CTD PMID:35362542 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:121,922,187...122,087,675 		JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of LAMTOR2 protein] CTD PMID:35362542 NCBI chr 2:176,306,353...176,310,617
Ensembl chr 2:176,306,280...176,310,730 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression
multiple interactions 		ISO evodiamine results in increased expression of LATS1 mRNA
evodiamine results in increased expression of and results in increased phosphorylation of LATS1 protein; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of and results in increased phosphorylation of LATS1 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of LATS1 mRNA] 		CTD PMID:32057900 NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 affects expression ISO evodiamine affects the expression of LEF1 mRNA CTD PMID:31835579 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Lgmn legumain multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of LGMN protein] CTD PMID:35362542 NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:127,308,913...127,347,328 		JBrowse link
G Lrp5 LDL receptor related protein 5 decreases expression ISO evodiamine results in decreased expression of LRP5 mRNA CTD PMID:31835579 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of LRPAP1 protein] CTD PMID:35362542 NCBI chr14:79,876,002...79,888,011
Ensembl chr14:79,875,708...79,890,034 		JBrowse link
G Lsm3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of LSM3 protein] CTD PMID:35362542 NCBI chr 4:125,578,185...125,584,429
Ensembl chr 4:125,578,185...125,584,429 		JBrowse link
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of LSM4 protein] CTD PMID:35362542 NCBI chr16:18,789,466...18,795,164
Ensembl chr16:18,789,467...18,794,886 		JBrowse link
G Luc7l3 LUC7 pre-mRNA splicing factor like 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of LUC7L3 protein] CTD PMID:35362542 NCBI chr10:79,737,457...79,773,478
Ensembl chr10:79,736,853...79,773,429 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MACF1 protein] CTD PMID:35362542 NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:140,908,837...141,233,890 		JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MAN1A protein] CTD PMID:35362542 NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,745,165...33,928,584 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation 		ISO
EXP 		chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]
evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
evodiamine results in decreased phosphorylation of MAPK1 protein
evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; evodiamine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein 		CTD PMID:17884939 PMID:19854188 PMID:28303407 PMID:34401976 PMID:39334374 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MAPK13 protein] CTD PMID:35362542 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation 		ISO
EXP 		chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]
evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; evodiamine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
evodiamine results in decreased phosphorylation of MAPK3 protein 		CTD PMID:17884939 PMID:19854188 PMID:28303407 PMID:34401976 PMID:39334374 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression 		ISO
EXP 		1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of MAPK8 protein modified form]
evodiamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
evodiamine inhibits the reaction [Bortezomib results in increased phosphorylation of MAPK8 protein] 		CTD PMID:23774672 PMID:34401976 PMID:38010754 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression 		ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of MAPK9 protein modified form] CTD PMID:23774672 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MCM3 protein] CTD PMID:35362542 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746 		JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MECR protein] CTD PMID:35362542 NCBI chr 5:149,313,765...149,339,964
Ensembl chr 5:149,313,774...149,342,825 		JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO evodiamine results in decreased expression of MEIS1 mRNA CTD PMID:32057900 NCBI chr14:97,356,949...97,499,646
Ensembl chr14:97,322,748...97,495,083 		JBrowse link
G Memo1 mediator of cell motility 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MEMO1 protein] CTD PMID:35362542 NCBI chr 6:26,895,497...26,986,248
Ensembl chr 6:26,896,290...26,986,442 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression
multiple interactions 		ISO evodiamine results in increased expression of MET mRNA
evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]; MET protein affects the reaction [evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of SRC protein]]; MET protein affects the reaction [evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of STAT3 protein]] 		CTD PMID:32183146 PMID:38878560 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mgat4c MGAT4 family, member C multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MGAT4C protein] CTD PMID:35362542 NCBI chr 7:38,596,117...39,361,103
Ensembl chr 7:38,596,065...39,362,078 		JBrowse link
G Micu2 mitochondrial calcium uptake 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MICU2 protein] CTD PMID:35362542 NCBI chr15:36,180,413...36,262,429
Ensembl chr15:36,170,832...36,262,686 		JBrowse link
G Mien1 migration and invasion enhancer 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MIEN1 protein] CTD PMID:35362542 NCBI chr10:83,931,485...83,932,778
Ensembl chr10:83,930,955...83,932,778 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression 		ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of MKI67 protein
evodiamine results in decreased expression of MKI67 protein 		CTD PMID:37611839 PMID:39486648 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO evodiamine results in decreased expression of MMP2 protein CTD PMID:32425601 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO evodiamine results in decreased expression of MMP7 protein CTD PMID:32425601 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of MMP9 protein] CTD PMID:15710601 PMID:32183146 PMID:32425601 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mob4 MOB family member 4, phocein multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MOB4 protein] CTD PMID:35362542 NCBI chr 9:64,111,170...64,135,740
Ensembl chr 9:64,111,718...64,135,779 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO evodiamine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:34401976 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MPST protein] CTD PMID:35362542 NCBI chr 7:111,836,079...111,843,651
Ensembl chr 7:111,835,587...111,843,650 		JBrowse link
G Mrpl22 mitochondrial ribosomal protein L22 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MRPL22 protein] CTD PMID:35362542 NCBI chr10:42,843,165...42,856,243
Ensembl chr10:42,843,222...42,856,227 		JBrowse link
G Msrb3 methionine sulfoxide reductase B3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MSRB3 protein] CTD PMID:35362542 NCBI chr 7:58,188,827...58,311,459
Ensembl chr 7:57,968,124...58,311,116 		JBrowse link
G Mst1 macrophage stimulating 1 increases expression
multiple interactions 		ISO evodiamine results in increased expression of MST1 mRNA; evodiamine results in increased expression of MST1 protein
XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of MST1 mRNA]; XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of MST1 protein] 		CTD PMID:32057900 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ND1 protein] CTD PMID:35362542 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685 		JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ND4 protein] CTD PMID:35362542 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,145...11,522 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO evodiamine results in decreased expression of MTOR mRNA; evodiamine results in decreased expression of MTOR protein CTD PMID:34824590 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO evodiamine results in decreased expression of MUC1 mRNA; evodiamine results in decreased expression of MUC1 protein alternative form CTD PMID:33208183 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MVD protein] CTD PMID:35362542 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression 		ISO evodiamine inhibits the reaction [TNF protein results in increased expression of MYC protein]
evodiamine results in increased expression of MYC mRNA
evodiamine results in decreased expression of MYC mRNA; evodiamine results in decreased expression of MYC protein 		CTD PMID:15710601 PMID:32057900 PMID:32425601 PMID:38878560 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of MYD88 protein] CTD PMID:35362542 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Myl4 myosin, light chain 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MYL4 protein] CTD PMID:35362542 NCBI chr10:89,949,733...89,985,308
Ensembl chr10:89,949,404...89,985,308 		JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of MZB1 protein] CTD PMID:35362542 NCBI chr18:27,513,087...27,515,148
Ensembl chr18:27,513,089...27,515,182 		JBrowse link
G Nagk N-acetylglucosamine kinase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of NAGK protein] CTD PMID:35362542 NCBI chr 4:117,838,761...117,846,304
Ensembl chr 4:117,838,826...117,847,836 		JBrowse link
G Nanog Nanog homeobox increases expression ISO evodiamine results in increased expression of NANOG mRNA CTD PMID:31835579 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Napg NSF attachment protein gamma multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of NAPG protein] CTD PMID:35362542 NCBI chr18:58,710,702...58,729,450
Ensembl chr18:58,708,655...58,729,450 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor decreases expression ISO evodiamine results in decreased expression of NF2 mRNA CTD PMID:32057900 NCBI chr14:83,850,894...83,934,263
Ensembl chr14:83,850,894...83,934,151 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO evodiamine inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15710601 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein; wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
[APC protein mutant form affects the susceptibility to evodiamine] which affects the phosphorylation of NFKBIA protein; evodiamine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein] 		CTD PMID:15710601 PMID:20005289 PMID:35362542 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of NGF mRNA]; evodiamine inhibits the reaction [Imiquimod results in increased expression of NGF protein] CTD PMID:38948922 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nipsnap1 nipsnap homolog 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of NIPSNAP1 protein] CTD PMID:35362542 NCBI chr14:83,957,714...83,981,579
Ensembl chr14:83,957,702...83,981,576 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP evodiamine inhibits the reaction [Uric Acid results in increased expression of NLRP3 protein] CTD PMID:37555854 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of NME1 protein] CTD PMID:35362542 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17109845 PMID:34401976 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Notch1 notch receptor 1 decreases expression ISO evodiamine results in decreased expression of NOTCH1 mRNA CTD PMID:31835579 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Nup133 nucleoporin 133 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of NUP133 protein] CTD PMID:35362542 NCBI chr19:68,789,065...68,838,692
Ensembl chr19:68,789,065...68,838,692 		JBrowse link
G Nup93 nucleoporin 93 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of NUP93 protein] CTD PMID:35362542 NCBI chr19:10,690,154...10,793,937
Ensembl chr19:10,687,115...10,793,380 		JBrowse link
G Nxn nucleoredoxin multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of NXN protein] CTD PMID:35362542 NCBI chr10:61,607,557...61,745,807
Ensembl chr10:61,607,568...61,745,807 		JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of OTC protein] CTD PMID:35362542 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Palm paralemmin multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PALM protein] CTD PMID:35362542 NCBI chr 7:10,537,252...10,563,346
Ensembl chr 7:10,537,277...10,563,007 		JBrowse link
G Pals1 protein associated with LIN7 1, MAGUK p55 family member increases expression ISO evodiamine results in increased expression of MPP5 mRNA CTD PMID:32057900 NCBI chr 6:103,327,965...103,384,543
Ensembl chr 6:103,281,154...103,387,209 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
increases cleavage 		ISO [HGF protein co-treated with evodiamine] results in increased cleavage of PARP1 protein; EUK-134 inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein]; evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; Rotenone inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein]
evodiamine results in increased expression of PARP1 protein 		CTD PMID:15710601 PMID:32183146 PMID:32425601 PMID:33208183 PMID:34808100 More... NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PARP9 protein] CTD PMID:35362542 NCBI chr11:78,286,282...78,320,409
Ensembl chr11:78,286,287...78,320,608 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PCK1 protein] CTD PMID:35362542 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO evodiamine results in decreased expression of PCNA protein CTD PMID:32425601 PMID:39334374 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PDCD4 protein] CTD PMID:35362542 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189 		JBrowse link
G Pdlim4 PDZ and LIM domain 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PDLIM4 protein] CTD PMID:35362542 NCBI chr10:38,699,444...38,713,696
Ensembl chr10:38,699,444...38,713,659 		JBrowse link
G Pds5a PDS5 cohesin associated factor A multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PDS5A protein] CTD PMID:35362542 NCBI chr14:42,905,734...43,004,740
Ensembl chr14:42,905,328...43,004,740 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PEA15A protein] CTD PMID:35362542 NCBI chr13:87,190,189...87,199,811
Ensembl chr13:87,187,295...87,199,859 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO evodiamine inhibits the reaction [TGFB1 protein results in decreased expression of PECAM1 protein] CTD PMID:28303407 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pfdn2 prefoldin subunit 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PFDN2 protein] CTD PMID:35362542 NCBI chr13:86,305,037...86,323,008 JBrowse link
G Pfdn6 prefoldin subunit 6 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PFDN6 protein] CTD PMID:35362542 NCBI chr20:4,947,844...4,949,318
Ensembl chr20:4,947,844...4,949,318 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PGRMC1 protein] CTD PMID:35362542 NCBI chr  X:120,698,610...120,706,805
Ensembl chr  X:120,698,610...120,706,805 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO evodiamine results in decreased phosphorylation of PIK3R1 protein CTD PMID:34824590 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pla2g4c phospholipase A2 group IVC multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PLA2G4C protein] CTD PMID:35362542 NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:83,382,068...83,410,037 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases phosphorylation 		ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein] CTD PMID:19854188 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcg2 phospholipase C, gamma 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PLCG2 protein] CTD PMID:35362542 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684 		JBrowse link
G Plekho2 pleckstrin homology domain containing O2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PLEKHO2 protein] CTD PMID:35362542 NCBI chr 8:74,973,578...75,000,532
Ensembl chr 8:74,974,740...75,000,430 		JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PNPT1 protein] CTD PMID:35362542 NCBI chr14:107,078,486...107,109,628
Ensembl chr14:107,078,469...107,109,628 		JBrowse link
G Polr2h RNA polymerase II, I and III subunit H multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of POLR2H protein] CTD PMID:35362542 NCBI chr11:93,696,423...93,701,902
Ensembl chr10:105,353,444...105,354,241
Ensembl chr11:105,353,444...105,354,241 		JBrowse link
G Potef-ps1 POTE ankyrin domain family, member F, pseudogene 1 increases expression ISO evodiamine results in increased expression of POTEF mRNA CTD PMID:32057900 NCBI chr18:23,900,710...24,602,964 JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of POU5F1 protein; [tetramethylpyrazine co-treated with evodiamine] inhibits the reaction [POU5F1 protein binds to ESR2 promoter] CTD PMID:39486648 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions 		ISO evodiamine results in decreased expression of PPARG
evodiamine inhibits the reaction [Dietary Fats results in decreased expression of PPARG protein] 		CTD PMID:17884939 PMID:34902249 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppic peptidylprolyl isomerase C multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PPIC protein] CTD PMID:35362542 NCBI chr18:49,040,690...49,053,296
Ensembl chr18:49,040,692...49,053,466 		JBrowse link
G Ppih peptidylprolyl isomerase H multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PPIH protein] CTD PMID:35362542 NCBI chr 5:138,191,624...138,209,625
Ensembl chr 5:138,191,624...138,209,580 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PPP1R1B protein] CTD PMID:35362542 NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063 		JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PPP2R5D protein] CTD PMID:35362542 NCBI chr 9:21,767,963...21,797,997
Ensembl chr 9:21,767,688...21,797,996 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PRKAA2 protein] CTD PMID:35362542 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases phosphorylation 		ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein] CTD PMID:19854188 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PRKG1 protein] CTD PMID:35362542 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005 		JBrowse link
G Prom1 prominin 1 decreases expression ISO evodiamine results in decreased expression of PROM1 mRNA CTD PMID:31835579 NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002 		JBrowse link
G Prorsd1 prolyl-tRNA synthetase associated domain containing 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of PRORSD1 protein] CTD PMID:35362542 NCBI chr14:107,458,910...107,461,179
Ensembl chr14:107,458,857...107,461,205 		JBrowse link
G Prpf4 pre-mRNA splicing tri-snRNP complex factor PRPF4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of PRPF4 protein] CTD PMID:35362542 NCBI chr 5:80,875,511...80,889,501
Ensembl chr 5:80,875,498...80,889,497 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO evodiamine results in increased expression of PTEN mRNA; evodiamine results in increased expression of PTEN protein CTD PMID:34824590 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions ISO [evodiamine co-treated with tetramethylpyrazine] results in decreased expression of PTGER3 mRNA CTD PMID:39486648 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; HGF protein affects the reaction [evodiamine results in decreased expression of PTGS2 protein]
evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] 		CTD PMID:15710601 PMID:32183146 PMID:34401976 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP evodiamine inhibits the reaction [Uric Acid results in increased expression of PYCARD protein] CTD PMID:37555854 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rab1b RAB1B, member RAS oncogene family multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of RAB1B protein] CTD PMID:35362542 NCBI chr 1:211,835,133...211,843,408
Ensembl chr 1:211,835,073...211,843,337
Ensembl chr  X:211,835,073...211,843,337 		JBrowse link
G Rab32 RAB32, member RAS oncogene family multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RAB32 protein] CTD PMID:35362542 NCBI chr 1:6,766,448...6,781,258
Ensembl chr 1:6,766,455...6,781,258 		JBrowse link
G Rab4b RAB4B, member RAS oncogene family multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RAB4B protein] CTD PMID:35362542 NCBI chr 1:91,589,047...91,600,426
Ensembl chr 1:91,589,047...91,600,337 		JBrowse link
G Ranbp3 RAN binding protein 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of RANBP3 protein] CTD PMID:35362542 NCBI chr 9:1,594,344...1,631,587
Ensembl chr 9:1,594,346...1,631,587 		JBrowse link
G Rbm47 RNA binding motif protein 47 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of RBM47 protein] CTD PMID:35362542 NCBI chr14:42,407,226...42,545,304
Ensembl chr14:42,466,335...42,543,163 		JBrowse link
G Rbpms RNA binding protein, mRNA processing factor multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RBPMS protein] CTD PMID:35362542 NCBI chr16:64,942,159...65,098,504
Ensembl chr16:64,942,530...65,098,503 		JBrowse link
G Rcn3 reticulocalbin 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RCN3 protein] CTD PMID:35362542 NCBI chr 1:104,700,969...104,710,228
Ensembl chr 1:104,700,545...104,710,249 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation 		ISO evodiamine inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of RELA protein]; evodiamine inhibits the reaction [IL6 protein results in increased phosphorylation of RELA protein]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; evodiamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; evodiamine inhibits the reaction [TNF protein affects the localization of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of RELA protein]; evodiamine results in decreased phosphorylation of and affects the localization of RELA protein
evodiamine results in decreased phosphorylation of RELA protein
[APC protein mutant form affects the susceptibility to evodiamine] which affects the phosphorylation of RELA protein; evodiamine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] 		CTD PMID:15710601 PMID:33277208 PMID:34401976 PMID:35362542 PMID:35899176 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rer1 retention in endoplasmic reticulum sorting receptor 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of RER1 protein] CTD PMID:35362542 NCBI chr 5:170,916,643...170,929,073
Ensembl chr 5:170,916,905...170,928,980 		JBrowse link
G Rexo2 RNA exonuclease 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of REXO2 protein] CTD PMID:35362542 NCBI chr 8:57,708,420...57,720,142
Ensembl chr 8:57,707,558...57,720,142 		JBrowse link
G Rgs10 regulator of G-protein signaling 10 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RGS10 protein] CTD PMID:35362542 NCBI chr 1:192,376,772...192,422,640
Ensembl chr 1:192,376,774...192,418,904 		JBrowse link
G Rnasel ribonuclease L multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RNASEL protein] CTD PMID:35362542 NCBI chr13:68,446,641...68,460,804
Ensembl chr13:68,446,882...68,459,557 		JBrowse link
G Rpl13a ribosomal protein L13A decreases expression ISO evodiamine results in decreased expression of RPL13A mRNA CTD PMID:32057900 NCBI chr 1:104,746,223...104,748,975
Ensembl chr 1:104,746,223...104,748,914 		JBrowse link
G Rps15 ribosomal protein S15 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of RPS15 protein] CTD PMID:35362542 NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:10,066,677...10,068,123 		JBrowse link
G Rps21-ps1 ribosomal protein S21, pseudogene 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of RPS21 protein] CTD PMID:35362542 NCBI chr 5:158,670,141...158,670,484
Ensembl chr 5:158,670,116...158,670,490 		JBrowse link
G RT1-Ba RT1 class II, locus Ba multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of H2-AA protein] CTD PMID:35362542 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of S100A4 protein] CTD PMID:35362542 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of S100A9 protein; evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of S100A9 protein]; evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of S100A9 protein] CTD PMID:35362542 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870 		JBrowse link
G Sav1 salvador family WW domain containing protein 1 increases expression ISO evodiamine results in increased expression of SAV1 mRNA CTD PMID:32057900 NCBI chr 6:94,214,514...94,236,354
Ensembl chr 6:94,214,517...94,235,945 		JBrowse link
G Scd stearoyl-CoA desaturase affects expression ISO evodiamine affects the expression of SCD mRNA CTD PMID:31835579 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Scrib scribble planar cell polarity protein increases expression ISO evodiamine results in increased expression of SCRIB mRNA CTD PMID:32057900 NCBI chr 7:109,640,034...109,663,354
Ensembl chr 7:109,640,034...109,663,022 		JBrowse link
G Sema3a semaphorin 3A multiple interactions
increases expression 		ISO evodiamine inhibits the reaction [Lactic Acid results in decreased expression of SEMA3A mRNA]; evodiamine inhibits the reaction [Lactic Acid results in decreased expression of SEMA3A protein]; ferrostatin-1 inhibits the reaction [evodiamine results in increased expression of SEMA3A protein] CTD PMID:37611839 NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:22,245,322...22,535,774 		JBrowse link
G Sf1 splicing factor 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SF1 protein] CTD PMID:35362542 NCBI chr 1:213,090,256...213,112,688
Ensembl chr 1:213,099,260...213,113,590 		JBrowse link
G Sgcd sarcoglycan, delta multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SGCD protein] CTD PMID:35362542 NCBI chr10:31,847,713...32,829,554
Ensembl chr10:31,781,748...32,419,064 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SHMT1 protein] CTD PMID:35362542 NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,960,434...45,997,326 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT2 protein] CTD PMID:35362542 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499 		JBrowse link
G Skic3 SKI3 subunit of superkiller complex multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SKIC3 protein] CTD PMID:35362542 NCBI chr 2:7,363,417...7,526,351
Ensembl chr 2:7,363,535...7,483,496 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SLC12A2 protein] CTD PMID:35362542 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470 		JBrowse link
G Slc22a18 solute carrier family 22, member 18 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SLC22A18 protein] CTD PMID:35362542 NCBI chr 1:208,100,032...208,124,382
Ensembl chr 1:208,101,136...208,124,380 		JBrowse link
G Slc25a13 solute carrier family 25 member 13 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SLC25A13 protein] CTD PMID:35362542 NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:35,145,721...35,328,360 		JBrowse link
G Slc30a7 solute carrier family 30 member 7 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SLC30A7 protein] CTD PMID:35362542 NCBI chr 2:206,544,800...206,607,087
Ensembl chr 2:206,544,800...206,607,043 		JBrowse link
G Slc35a1 solute carrier family 35 member A1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SLC35A1 protein] CTD PMID:35362542 NCBI chr 5:54,021,896...54,044,677
Ensembl chr 5:54,021,896...54,044,677 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SLC4A7 protein] CTD PMID:35362542 NCBI chr15:13,015,854...13,095,485
Ensembl chr15:13,015,854...13,095,292 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO
EXP 		evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:28303407 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP
ISO 		evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD3 protein] CTD PMID:28303407 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP
ISO 		evodiamine inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]
evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SMAD4 protein] 		CTD PMID:28303407 PMID:35362542 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SMARCB1 protein] CTD PMID:35362542 NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055 		JBrowse link
G Smarce1 SWI/SNF related BAF chromatin remodeling complex subunit E1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SMARCE1 protein] CTD PMID:35362542 NCBI chr10:84,655,468...84,678,259
Ensembl chr10:84,655,468...84,676,185 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO evodiamine results in increased expression of SMO mRNA CTD PMID:31835579 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SMPD3 protein] CTD PMID:35362542 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SMPDL3A protein] CTD PMID:35362542 NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO evodiamine results in decreased expression of SNAI1 protein CTD PMID:32425601 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SNRPF protein] CTD PMID:35362542 NCBI chr 7:30,017,460...30,024,162
Ensembl chr 7:30,017,460...30,024,162 		JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of SNRPG protein] CTD PMID:35362542 NCBI chr 4:120,369,676...120,377,263
Ensembl chr 4:120,369,685...120,377,261
Ensembl chr  X:120,369,685...120,377,261 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SPINK1 protein] CTD PMID:35362542 NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases expression
multiple interactions 		ISO evodiamine results in decreased expression of SRC protein
evodiamine inhibits the reaction [Dihydrotestosterone promotes the reaction [SRC protein binds to AR protein]]; evodiamine inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of SRC protein]; evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of SRC protein]; MET protein affects the reaction [evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of SRC protein]] 		CTD PMID:32183146 PMID:34713388 PMID:39334374 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SRRM2 protein] CTD PMID:35362542 NCBI chr10:13,320,059...13,353,337
Ensembl chr10:13,320,059...13,353,337 		JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SRSF11 protein] CTD PMID:35362542 NCBI chr 2:249,733,464...249,760,296
Ensembl chr 2:249,733,464...249,760,499 		JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ST3GAL6 protein] CTD PMID:35362542 NCBI chr11:55,530,120...55,590,950
Ensembl chr11:55,530,248...55,598,720 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of STAT1 protein] CTD PMID:35362542 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions 		ISO evodiamine results in decreased phosphorylation of STAT3 protein
evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of and affects the localization of STAT3 protein]; evodiamine inhibits the reaction [IL6 protein affects the localization of STAT3 protein]; evodiamine inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; MET protein affects the reaction [evodiamine inhibits the reaction [HGF protein results in increased phosphorylation of STAT3 protein]] 		CTD PMID:32183146 PMID:33277208 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stk3 serine/threonine kinase 3 decreases expression
multiple interactions
increases expression 		ISO evodiamine results in decreased expression of STK3 mRNA
XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of STK3 mRNA]
evodiamine results in increased expression of STK3 protein 		CTD PMID:32057900 NCBI chr 7:67,938,341...68,208,472
Ensembl chr 7:67,938,378...68,208,508 		JBrowse link
G Sun1 Sad1 and UNC84 domain containing 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SUN1 protein] CTD PMID:35362542 NCBI chr12:20,510,230...20,555,123
Ensembl chr12:20,490,861...20,555,240 		JBrowse link
G Susd2 sushi domain containing 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SUSD2 protein] CTD PMID:35362542 NCBI chr20:13,016,960...13,024,264
Ensembl chr20:13,016,907...13,024,264 		JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SYNE2 protein] CTD PMID:35362542 NCBI chr 6:100,272,729...100,586,364
Ensembl chr 6:100,272,729...100,583,723 		JBrowse link
G Syvn1 synoviolin 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of SYVN1 protein] CTD PMID:35362542 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of TAC1 mRNA]; evodiamine inhibits the reaction [Imiquimod results in increased expression of TAC1 protein] CTD PMID:38948922 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Taok1 TAO kinase 1 increases expression ISO evodiamine results in increased expression of TAOK1 mRNA CTD PMID:32057900 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,871,198...62,957,595 		JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO evodiamine results in decreased expression of TAOK3 mRNA CTD PMID:32057900 NCBI chr12:44,973,180...45,134,439
Ensembl chr12:44,973,180...45,134,439 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of TAP1 protein] CTD PMID:35362542 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810 		JBrowse link
G Tbl2 transducin (beta)-like 2 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TBL2 protein] CTD PMID:35362542 NCBI chr12:27,154,150...27,168,446
Ensembl chr12:27,154,150...27,168,446 		JBrowse link
G Tead1 TEA domain transcription factor 1 increases expression ISO evodiamine results in increased expression of TEAD1 mRNA CTD PMID:32057900 NCBI chr 1:176,227,175...176,445,122
Ensembl chr 1:176,227,175...176,438,198 		JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO evodiamine results in increased expression of TGFA mRNA CTD PMID:38878560 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression 		ISO
EXP 		evodiamine inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]; evodiamine inhibits the reaction [TGFB1 protein results in decreased expression of CD34 protein]; evodiamine inhibits the reaction [TGFB1 protein results in decreased expression of PECAM1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD2 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD3 protein]
evodiamine results in increased expression of TGFB1 mRNA
evodiamine inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD2 protein]; evodiamine inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD3 protein] 		CTD PMID:28303407 PMID:32057900 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgm3 transglutaminase 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TGM3 protein] CTD PMID:35362542 NCBI chr 3:137,681,809...137,717,219
Ensembl chr 3:137,681,809...137,717,219 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO evodiamine results in increased expression of THBS1 mRNA CTD PMID:38878560 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein] CTD PMID:35362542 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tmem30b transmembrane protein 30B multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TMEM30B protein] CTD PMID:35362542 NCBI chr 6:97,987,471...97,990,546
Ensembl chr 6:97,987,130...97,991,170 		JBrowse link
G Tmsb10 thymosin, beta 10 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of TMSB10 protein] CTD PMID:35362542 NCBI chr 4:106,568,080...106,569,210 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		[evodiamine co-treated with tetramethylpyrazine] results in decreased expression of TNF mRNA; [evodiamine co-treated with tetramethylpyrazine] results in decreased secretion of TNF protein; evodiamine inhibits the reaction [TNF protein affects the localization of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of CHUK protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of MYC protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein]; evodiamine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]
[APC protein mutant form affects the susceptibility to evodiamine] which affects the expression of TNF protein; evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; evodiamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; evodiamine inhibits the reaction [Imiquimod results in increased expression of TNF protein]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
evodiamine inhibits the reaction [Uric Acid results in increased expression of TNF protein] 		CTD PMID:15710601 PMID:34218553 PMID:34401976 PMID:35362542 PMID:37555854 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tomm5 translocase of outer mitochondrial membrane 5 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of TOMM5 protein] CTD PMID:35362542 NCBI chr 5:64,158,026...64,160,857 JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO evodiamine binds to and results in decreased activity of TOP1 protein CTD PMID:26207989 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		ISO evodiamine results in increased expression of TP53 protein
XMU-MP-1 inhibits the reaction [evodiamine results in increased expression of TP53 protein] 		CTD PMID:32057900 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO evodiamine results in decreased expression of TP63 mRNA CTD PMID:32057900 NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases expression 		ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of TRPV1 mRNA]; evodiamine inhibits the reaction [Imiquimod results in increased expression of TRPV1 protein]
evodiamine results in increased expression of TRPV1 mRNA; evodiamine results in increased expression of TRPV1 protein 		CTD PMID:38878560 PMID:38948922 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of TRPV3 mRNA]; evodiamine inhibits the reaction [Imiquimod results in increased expression of TRPV3 protein] CTD PMID:38948922 NCBI chr10:58,382,054...58,413,657
Ensembl chr10:58,382,054...58,411,800 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions ISO evodiamine inhibits the reaction [Imiquimod results in increased expression of TRPV4 mRNA]; evodiamine inhibits the reaction [Imiquimod results in increased expression of TRPV4 protein] CTD PMID:38948922 NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143 		JBrowse link
G Tsfm Ts translation elongation factor, mitochondrial multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TSFM protein] CTD PMID:35362542 NCBI chr 7:64,714,330...64,750,106
Ensembl chr 7:64,714,036...64,750,171 		JBrowse link
G Tshz1 teashirt zinc finger homeobox 1 decreases expression ISO evodiamine results in decreased expression of TSHZ1 mRNA CTD PMID:32057900 NCBI chr18:79,651,256...79,727,662
Ensembl chr18:79,651,256...79,727,662 		JBrowse link
G Twist2 twist family bHLH transcription factor 2 increases expression ISO evodiamine results in increased expression of TWIST2 mRNA CTD PMID:31835579 NCBI chr 9:99,822,242...99,866,722
Ensembl chr 9:99,818,962...99,920,270 		JBrowse link
G Txndc9 thioredoxin domain containing 9 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of TXNDC9 protein] CTD PMID:35362542 NCBI chr 9:47,707,628...47,717,761
Ensembl chr 9:47,707,231...47,880,085 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions EXP evodiamine inhibits the reaction [Uric Acid results in increased expression of TXNIP protein] CTD PMID:37555854 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of UBA7 protein] CTD PMID:35362542 NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:117,543,957...117,556,142 		JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of UBE2D3 protein] CTD PMID:35362542 NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:226,540,531...226,573,144 		JBrowse link
G Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of UBLCP1 protein] CTD PMID:35362542 NCBI chr10:29,447,081...29,462,446
Ensembl chr10:29,447,081...29,462,386 		JBrowse link
G Ubtf upstream binding transcription factor multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of UBTF protein] CTD PMID:35362542 NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,758,346...87,773,088 		JBrowse link
G Upp1 uridine phosphorylase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of UPP1 protein] CTD PMID:35362542 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:88,023,351...88,043,034 		JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of UROD protein] CTD PMID:35362542 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:135,701,296...135,705,380 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression 		ISO evodiamine results in increased expression of VEGFA mRNA
evodiamine results in decreased expression of VEGFA protein 		CTD PMID:32183146 PMID:38878560 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vim vimentin multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
evodiamine results in decreased expression of VIM protein 		CTD PMID:28303407 PMID:32425601 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of VPS26C protein] CTD PMID:35362542 NCBI chr11:47,283,764...47,311,105
Ensembl chr11:47,262,071...47,311,045 		JBrowse link
G Wasl WASP like actin nucleation promoting factor multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of WASL protein] CTD PMID:35362542 NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:54,049,082...54,097,570 		JBrowse link
G Wdr5 WD repeat domain 5 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of WDR5 protein] CTD PMID:35362542 NCBI chr 3:31,233,048...31,254,730
Ensembl chr 3:31,235,222...31,254,727 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of XDH protein] CTD PMID:35362542 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression 		ISO evodiamine inhibits the reaction [EGF protein results in increased expression of XIAP protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein]
evodiamine results in decreased expression of XIAP protein 		CTD PMID:15710601 PMID:39334374 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
G Xpnpep1 X-prolyl aminopeptidase 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of XPNPEP1 protein] CTD PMID:35362542 NCBI chr 1:262,006,761...262,057,479
Ensembl chr 1:262,006,761...262,092,425 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression
multiple interactions 		ISO evodiamine results in decreased expression of YAP1 mRNA; evodiamine results in decreased expression of YAP1 protein
evodiamine results in increased phosphorylation of and affects the localization of YAP1 protein; XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of YAP1 mRNA]; XMU-MP-1 inhibits the reaction [evodiamine results in decreased expression of YAP1 protein]; XMU-MP-1 inhibits the reaction [evodiamine results in increased phosphorylation of YAP1 protein] 		CTD PMID:32057900 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma increases expression ISO evodiamine results in increased expression of YWHAG mRNA CTD PMID:38878560 NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO evodiamine results in increased expression of YWHAQ mRNA CTD PMID:32057900 NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO evodiamine results in increased expression of YWHAZ mRNA CTD PMID:32057900 PMID:38878560 NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:69,826,404...69,849,007 		JBrowse link
G Zbp1 Z-DNA binding protein 1 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ZBP1 protein] CTD PMID:35362542 NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:182,411,665...182,422,839 		JBrowse link
G Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 increases expression ISO evodiamine results in increased expression of ZDHHC18 mRNA CTD PMID:32057900 NCBI chr 5:151,105,303...151,143,843
Ensembl chr 5:151,105,201...151,143,769 		JBrowse link
G Zfp422 zinc finger protein 422 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ZFP422 protein] CTD PMID:35362542 NCBI chr 4:151,558,254...151,565,730
Ensembl chr 4:151,556,738...151,566,152 		JBrowse link
G Zg16 zymogen granule protein 16 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in decreased expression of ZG16 protein] CTD PMID:35362542 NCBI chr 1:191,088,248...191,090,605
Ensembl chr 1:191,088,248...191,090,605 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 multiple interactions ISO evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of ZMPSTE24 protein] CTD PMID:35362542 NCBI chr 5:139,912,395...139,945,532
Ensembl chr 5:139,913,671...139,945,532 		JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Harmaline affects the reaction [Epinephrine results in increased activity of ADRB1 protein] CTD PMID:30155694 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Harmaline inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein] CTD PMID:30155694 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Harmaline results in increased expression of CDH1 protein CTD PMID:35963316 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability 		ISO [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein 		CTD PMID:22037238 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Eng endoglin decreases expression
multiple interactions 		ISO Harmaline results in decreased expression of ENG mRNA
Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA] 		CTD PMID:35963316 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Ifng interferon gamma increases secretion ISO Harmaline results in increased secretion of IFNG protein CTD PMID:35963316 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 affects secretion
multiple interactions 		ISO Harmaline affects the secretion of IL4 protein
Doxorubicin affects the reaction [Harmaline results in decreased secretion of IL4 protein] 		CTD PMID:35963316 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression 		ISO Doxorubicin promotes the reaction [Harmaline results in decreased expression of KDR mRNA] CTD PMID:35963316 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP
ISO 		Harmaline results in decreased activity of MAOA protein CTD PMID:15178694 PMID:24373881 PMID:28302559 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Harmaline results in decreased expression of MKI67 protein CTD PMID:35963316 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Harmaline results in decreased expression of MMP2 protein CTD PMID:35963316 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression 		ISO Doxorubicin promotes the reaction [Harmaline results in decreased expression of PTGS2 mRNA] CTD PMID:35963316 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression 		ISO Doxorubicin promotes the reaction [Harmaline results in decreased expression of VEGFA mRNA]
Harmaline results in decreased expression of VEGFA mRNA; Harmaline results in decreased expression of VEGFA protein 		CTD PMID:35963316 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity
increases expression 		ISO harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA 		CTD PMID:27590872 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity 		ISO [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein 		CTD PMID:22037238 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression 		ISO harman results in increased cleavage of CASP3 protein
harman results in increased expression of CASP3 mRNA 		CTD PMID:35985368 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases expression ISO harman results in increased expression of CASP7 mRNA CTD PMID:35985368 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases expression ISO harman results in increased expression of CASP9 mRNA CTD PMID:35985368 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase decreases activity ISO harman results in decreased activity of CAT protein CTD PMID:35985368 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity 		ISO
EXP 		AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein 		CTD PMID:20732341 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO harman results in increased expression of HMOX1 mRNA CTD PMID:35985368 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO harman results in increased expression of NFE2L2 protein CTD PMID:35985368 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO harman results in increased expression of NQO1 mRNA CTD PMID:35985368 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO harman results in increased cleavage of PARP1 protein CTD PMID:35985368 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity 		ISO harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein 		CTD PMID:30189235 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions 		ISO harman results in decreased activity of SLC22A2 protein
harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] 		CTD PMID:30189235 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions 		ISO harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP 		CTD PMID:19725810 NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981 		JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Harmine results in decreased activity of ACHE protein CTD PMID:34078836 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Harmine affects the reaction [Epinephrine results in increased activity of ADRB1 protein] CTD PMID:30155694 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Harmine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein] CTD PMID:30155694 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Axin2 axin 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP harmine decreases expression of camk2d protein after myocardial infarction in rat heart left ventricle RGD PMID:26067684 RGD:11097969 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation EXP Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B decreases expression ISO Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions
increases phosphorylation 		ISO AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter] CTD PMID:27805061 NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions
increases expression 		ISO Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein 		CTD PMID:27805061 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein 		CTD PMID:22001777 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A multiple interactions
decreases expression
affects binding
decreases activity 		ISO
EXP 		Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
harmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein 		CTD
RGD		 PMID:21573099 PMID:25751815 PMID:26067684 RGD:11097969 NCBI chr11:47,360,824...47,479,033
Ensembl chr11:47,360,850...47,479,033 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087 		JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 increases expression ISO Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Mafa MAF bZIP transcription factor A increases expression ISO Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:109,313,121...109,315,760 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP
ISO 		Harmine results in decreased activity of MAOA protein CTD PMID:24373881 PMID:28302559 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 affects localization ISO Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 affects localization ISO Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:177,618,314...177,747,380 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 affects localization ISO Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 affects localization ISO Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582 		JBrowse link
G Nkx6-1 NK6 homeobox 1 increases expression ISO Harmine results in increased expression of NKX6.1 mRNA; Harmine results in increased expression of NKX6.1 protein CTD PMID:25751815 NCBI chr14:8,274,238...8,281,171
Ensembl chr14:8,274,238...8,281,163 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156 		JBrowse link
G Pln phospholamban increases expression EXP harmine increases expression of Pln protein after myocardial infarction in rat heart left ventricle RGD PMID:26067684 RGD:11097969 NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression 		ISO [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein 		CTD PMID:20519739 PMID:27805061 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions 		ISO Harmine results in increased expression of PPARGC1A protein
Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA] 		CTD PMID:27805061 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prdm16 PR/SET domain 16 increases expression
multiple interactions 		ISO Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA] 		CTD PMID:27805061 NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:170,162,275...170,485,804 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions 		ISO Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA] 		CTD PMID:27805061 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,533,734...44,577,919 		JBrowse link
harmol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO harmol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [harmol results in decreased stability of CYP1A1 protein]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
harmol results in decreased activity of CYP1A1 protein 		CTD PMID:22001777 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions EXP
ISO 		Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol] CTD PMID:11181495 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
Rutecarpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO rutecarpine results in decreased expression of ACTA2 mRNA CTD PMID:34955744 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ada adenosine deaminase decreases expression ISO rutecarpine results in decreased expression of ADA mRNA CTD PMID:34955744 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
increases expression
multiple interactions
affects binding 		ISO
EXP 		rutecarpine results in increased localization of AHR protein
rutecarpine results in increased expression of AHR mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased localization of AHR protein]; AHR affects the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; rutecarpine promotes the reaction [AHR protein binds to CYP1A1 promoter]; W 7 inhibits the reaction [rutecarpine results in increased localization of AHR protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine binds to AHR protein]; rutecarpine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; W 7 inhibits the reaction [rutecarpine binds to AHR protein] 		CTD PMID:19853001 PMID:20449727 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO rutecarpine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866 		JBrowse link
G Amotl2 angiomotin like 2 decreases expression ISO rutecarpine results in decreased expression of AMOTL2 mRNA CTD PMID:34955744 NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:112,181,863...112,198,030 		JBrowse link
G Angpt1 angiopoietin 1 decreases expression ISO rutecarpine results in decreased expression of ANGPT1 mRNA CTD PMID:34955744 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Anln anillin, actin binding protein decreases expression ISO rutecarpine results in decreased expression of ANLN mRNA CTD PMID:34955744 NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:29,134,222...29,197,513 		JBrowse link
G Arhgef39 Rho guanine nucleotide exchange factor 39 decreases expression ISO rutecarpine results in decreased expression of ARHGEF39 mRNA CTD PMID:34955744 NCBI chr 5:62,548,300...62,551,870
Ensembl chr 5:62,548,303...62,551,870 		JBrowse link
G Astn2 astrotactin 2 decreases expression ISO rutecarpine results in decreased expression of ASTN2 mRNA CTD PMID:34955744 NCBI chr 5:83,772,988...84,759,439
Ensembl chr 5:83,773,633...84,759,485 		JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO rutecarpine results in increased expression of BEX4 mRNA CTD PMID:34955744 NCBI chr  X:103,923,609...103,925,041
Ensembl chr  X:103,923,338...103,925,496 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO rutecarpine results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,742,875...9,786,861 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO rutecarpine results in decreased expression of BMPR1B mRNA CTD PMID:25633564 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:233,211,525...233,544,311 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 decreases expression ISO rutecarpine results in decreased expression of BMPR2 mRNA CTD PMID:25633564 NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:68,685,988...68,801,350 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I increases phosphorylation ISO rutecarpine results in increased phosphorylation of CAMK1 protein CTD PMID:19853001 NCBI chr 4:148,036,843...148,047,675
Ensembl chr 4:148,036,824...148,047,245 		JBrowse link
G Card10 caspase recruitment domain family, member 10 increases expression ISO rutecarpine results in increased expression of CARD10 mRNA CTD PMID:34955744 NCBI chr 7:112,210,944...112,252,044
Ensembl chr 7:112,210,776...112,239,806 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; rutecarpine inhibits the reaction [Glucose results in increased activity of CASP3 protein]; rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]] CTD PMID:28025122 PMID:36928891 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO rutecarpine results in increased expression of CCL20 mRNA CTD PMID:34955744 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO rutecarpine results in decreased expression of CCN2 mRNA CTD PMID:34955744 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Cd24 CD24 molecule decreases expression ISO rutecarpine results in decreased expression of CD24 mRNA CTD PMID:34955744 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO rutecarpine results in decreased expression of CDK1 mRNA CTD PMID:34955744 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 increases expression ISO rutecarpine results in increased expression of CEMIP2 mRNA CTD PMID:34955744 NCBI chr 1:228,756,826...228,834,313
Ensembl chr 1:228,757,466...228,832,906 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO rutecarpine results in decreased expression of COL1A1 mRNA CTD PMID:34955744 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO rutecarpine results in decreased expression of COL1A2 mRNA CTD PMID:34955744 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Coro1a coronin 1A decreases expression ISO rutecarpine results in decreased expression of CORO1A mRNA CTD PMID:34955744 NCBI chr 1:190,726,129...190,731,133
Ensembl chr 1:190,726,130...190,731,102 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
affects binding 		ISO
EXP 		1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; AHR affects the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; capsazepine inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; capsazepine inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; rutecarpine promotes the reaction [AHR protein binds to CYP1A1 promoter]; rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein; W 7 inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; W 7 inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine binds to CYP1A1 promoter]; W 7 inhibits the reaction [rutecarpine binds to CYP1A1 promoter] 		CTD PMID:19853001 PMID:20449727 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases activity 		EXP
ISO 		rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]
rutecarpine analog binds to and results in decreased activity of CYP1A2 protein; rutecarpine binds to and results in decreased activity of CYP1A2 protein
rutecarpine results in increased activity of CYP1A2 protein 		CTD PMID:12852960 PMID:15720787 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression 		ISO rutecarpine analog binds to and results in decreased activity of CYP1B1 protein
rutecarpine results in increased expression of CYP1B1 mRNA 		CTD PMID:12852960 PMID:34955744 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Dcc DCC netrin 1 receptor decreases expression ISO rutecarpine results in decreased expression of DCC mRNA CTD PMID:34955744 NCBI chr18:67,144,272...68,248,159
Ensembl chr18:67,149,179...68,247,541 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 decreases expression ISO rutecarpine results in decreased expression of WDR63 mRNA CTD PMID:34955744 NCBI chr 2:237,608,202...237,666,465
Ensembl chr 2:237,604,068...237,666,465 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 decreases expression ISO rutecarpine results in decreased expression of EFEMP1 mRNA CTD PMID:34955744 NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808 		JBrowse link
G Epha2 Eph receptor A2 decreases expression ISO rutecarpine results in decreased expression of EPHA2 mRNA CTD PMID:34955744 NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO rutecarpine results in increased expression of F3 mRNA CTD PMID:34955744 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO rutecarpine results in decreased expression of FAM83D mRNA CTD PMID:34955744 NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:167,841,791...167,861,061 		JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO rutecarpine results in decreased expression of FBXO5 mRNA CTD PMID:34955744 NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:44,601,412...44,607,781 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 decreases expression ISO rutecarpine results in decreased expression of FERMT1 mRNA CTD PMID:34955744 NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:140,624,434...140,666,419 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO rutecarpine results in increased expression of FGF2 mRNA CTD PMID:34955744 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fgf7 fibroblast growth factor 7 decreases expression ISO rutecarpine results in decreased expression of FGF7 mRNA CTD PMID:34955744 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328 		JBrowse link
G Foxg1 forkhead box G1 decreases expression ISO rutecarpine results in decreased expression of FOXG1 mRNA CTD PMID:34955744 NCBI chr 6:72,401,582...72,404,392
Ensembl chr 6:72,394,239...72,427,392 		JBrowse link
G Frmd5 FERM domain containing 5 decreases expression ISO rutecarpine results in decreased expression of FRMD5 mRNA CTD PMID:34955744 NCBI chr 3:128,945,812...129,217,134
Ensembl chr 3:128,927,671...129,217,074 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO rutecarpine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:143,757,389...143,770,430
Ensembl chr 1:143,757,391...143,773,497 		JBrowse link
G Gpnmb glycoprotein nmb decreases expression ISO rutecarpine results in decreased expression of GPNMB mRNA CTD PMID:34955744 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] CTD PMID:28025122 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO rutecarpine results in increased expression of GREM1 mRNA CTD PMID:34955744 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 decreases expression ISO rutecarpine results in decreased expression of GTSE1 mRNA CTD PMID:34955744 NCBI chr 7:118,829,793...118,846,662
Ensembl chr 7:118,829,903...118,846,661 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression 		ISO rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
rutecarpine results in decreased expression of HAMP mRNA 		CTD PMID:25633564 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Has2 hyaluronan synthase 2 increases expression ISO rutecarpine results in increased expression of HAS2 mRNA CTD PMID:34955744 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535 		JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO rutecarpine results in decreased expression of HJV mRNA CTD PMID:25633564 NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:186,754,811...186,758,867 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO rutecarpine results in increased expression of HSPA5 mRNA CTD PMID:34955744 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO rutecarpine results in increased expression of ICAM1 mRNA CTD PMID:34955744 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO rutecarpine results in decreased expression of ID1 mRNA CTD PMID:34955744 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO rutecarpine results in increased expression of IGFBP3 mRNA CTD PMID:34955744 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO rutecarpine results in decreased expression of IGFBP5 mRNA CTD PMID:34955744 NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B protein]]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B protein]
rutecarpine results in increased expression of IL1B mRNA 		CTD PMID:34955744 PMID:36928891 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il24 interleukin 24 increases expression ISO rutecarpine results in increased expression of IL24 mRNA CTD PMID:34955744 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 protein]]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 protein]; rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 PMID:36928891 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irs2 insulin receptor substrate 2 increases expression ISO rutecarpine results in increased expression of IRS2 mRNA CTD PMID:34955744 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543 		JBrowse link
G Itga11 integrin subunit alpha 11 increases expression ISO rutecarpine results in increased expression of ITGA11 mRNA CTD PMID:34955744 NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137 		JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO rutecarpine results in increased expression of ITGA2 mRNA CTD PMID:34955744 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Itgb3 integrin subunit beta 3 increases expression ISO rutecarpine results in increased expression of ITGB3 mRNA CTD PMID:34955744 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Itgb8 integrin subunit beta 8 increases expression ISO rutecarpine results in increased expression of ITGB8 mRNA CTD PMID:34955744 NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:146,165,484...146,351,245 		JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 decreases expression ISO rutecarpine results in decreased expression of KANK1 mRNA CTD PMID:34955744 NCBI chr 1:232,381,720...232,500,834
Ensembl chr 1:232,445,658...232,500,839 		JBrowse link
G Lama4 laminin subunit alpha 4 decreases expression ISO rutecarpine results in decreased expression of LAMA4 mRNA CTD PMID:34955744 NCBI chr20:43,946,898...44,087,972
Ensembl chr20:43,946,898...44,087,972 		JBrowse link
G Lpxn leupaxin increases expression ISO rutecarpine results in increased expression of LPXN mRNA CTD PMID:34955744 NCBI chr 1:219,353,319...219,387,743
Ensembl chr 1:219,353,708...219,387,742 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]]; rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein] CTD PMID:36928891 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Matn2 matrilin 2 decreases expression ISO rutecarpine results in decreased expression of MATN2 mRNA CTD PMID:34955744 NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:67,380,168...67,530,153 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO rutecarpine results in increased expression of MMP1 mRNA CTD PMID:34955744 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp14 matrix metallopeptidase 14 increases expression ISO rutecarpine results in increased expression of MMP14 mRNA CTD PMID:34955744 NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893 		JBrowse link
G Mylk myosin light chain kinase decreases expression ISO rutecarpine results in decreased expression of MYLK mRNA CTD PMID:34955744 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO rutecarpine results in increased expression of NFE2L2 mRNA CTD PMID:34955744 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO rutecarpine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17109845 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein] CTD PMID:28025122 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression ISO rutecarpine results in decreased expression of NR2F1 mRNA CTD PMID:34955744 NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO rutecarpine results in decreased expression of NR4A2 mRNA CTD PMID:34955744 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769 		JBrowse link
G Ntn4 netrin 4 increases expression ISO rutecarpine results in increased expression of NTN4 mRNA CTD PMID:34955744 NCBI chr 7:30,073,637...30,187,407
Ensembl chr 7:30,073,333...30,188,309 		JBrowse link
G Ntng1 netrin G1 decreases expression ISO rutecarpine results in decreased expression of NTNG1 mRNA CTD PMID:34955744 NCBI chr 2:200,151,979...200,515,031
Ensembl chr 2:200,151,979...200,515,031 		JBrowse link
G Plk2 polo-like kinase 2 decreases expression ISO rutecarpine results in decreased expression of PLK2 mRNA CTD PMID:34955744 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO rutecarpine results in decreased expression of PPARGC1A mRNA CTD PMID:34955744 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prag1 PEAK1 related kinase activating pseudokinase 1 decreases expression ISO rutecarpine results in decreased expression of PRAG1 mRNA CTD PMID:34955744 NCBI chr16:62,791,249...62,844,532
Ensembl chr16:62,786,329...62,844,532 		JBrowse link
G Prr5l proline rich 5 like decreases expression ISO rutecarpine results in decreased expression of PRR5L mRNA CTD PMID:34955744 NCBI chr 3:108,458,107...108,628,552
Ensembl chr 3:108,458,633...108,537,763 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO rutecarpine results in increased expression of PTGS2 mRNA CTD PMID:34955744 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptn pleiotrophin decreases expression ISO rutecarpine results in decreased expression of PTN mRNA CTD PMID:34955744 NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482 		JBrowse link
G Scg2 secretogranin II decreases expression ISO rutecarpine results in decreased expression of SCG2 mRNA CTD PMID:34955744 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598 		JBrowse link
G Sdc1 syndecan 1 decreases expression ISO rutecarpine results in decreased expression of SDC1 mRNA CTD PMID:34955744 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 increases expression ISO rutecarpine results in increased expression of SFRP2 mRNA CTD PMID:34955744 NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:171,387,385...171,395,079 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO rutecarpine results in increased expression of SLC3A2 mRNA CTD PMID:34955744 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO rutecarpine results in increased expression of SLC7A11 mRNA CTD PMID:34955744 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO rutecarpine results in increased expression of SLC7A5 mRNA CTD PMID:34955744 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 increases expression ISO rutecarpine results in increased expression of SPRY2 mRNA CTD PMID:34955744 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:89,103,731...89,115,074 		JBrowse link
G Srgap3 SLIT-ROBO Rho GTPase activating protein 3 increases expression ISO rutecarpine results in increased expression of SRGAP3 mRNA CTD PMID:34955744 NCBI chr 4:147,391,082...147,626,407
Ensembl chr 4:147,395,880...147,625,713 		JBrowse link
G Srpx2 sushi-repeat-containing protein, X-linked 2 decreases expression ISO rutecarpine results in decreased expression of SRPX2 mRNA CTD PMID:34955744 NCBI chr  X:101,399,748...101,425,486
Ensembl chr  X:101,399,853...101,425,484 		JBrowse link
G Ssh1 slingshot protein phosphatase 1 increases expression ISO rutecarpine results in increased expression of SSH1 mRNA CTD PMID:34955744 NCBI chr12:48,281,756...48,343,812
Ensembl chr12:48,281,756...48,343,812 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO rutecarpine results in increased expression of THBS1 mRNA CTD PMID:34955744 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 decreases expression ISO rutecarpine results in decreased expression of TMEFF2 mRNA CTD PMID:34955744 NCBI chr 9:57,937,873...58,225,372
Ensembl chr 9:57,937,873...58,225,372 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO rutecarpine results in decreased expression of TMSB4X mRNA CTD PMID:34955744 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:30,761,612...30,763,613 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion 		ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein]]; rutecarpine inhibits the reaction [Glucose results in increased expression of TNF mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein]
rutecarpine results in decreased secretion of TNF protein 		CTD PMID:36928891 PMID:38041080 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO rutecarpine results in decreased expression of VCAM1 mRNA CTD PMID:34955744 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO rutecarpine results in increased expression of WNT5A mRNA CTD PMID:34955744 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860 		JBrowse link
G Wnt5b Wnt family member 5B decreases expression ISO rutecarpine results in decreased expression of WNT5B mRNA CTD PMID:34955744 NCBI chr 4:154,281,852...154,406,081
Ensembl chr 4:154,281,852...154,405,681 		JBrowse link
G Wwc1 WW and C2 domain containing 1 decreases expression ISO rutecarpine results in decreased expression of WWC1 mRNA CTD PMID:34955744 NCBI chr10:20,804,173...20,958,437
Ensembl chr10:20,799,237...20,958,437 		JBrowse link
tubastatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule decreases expression ISO tubastatin A results in decreased expression of CD274 protein CTD PMID:26775640 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions
decreases activity 		ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HDAC6 protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of HDAC6 protein]
tubastatin A results in decreased activity of HDAC6 protein 		CTD PMID:26775640 PMID:34910997 NCBI chr  X:17,222,538...17,244,373
Ensembl chr  X:17,222,856...17,244,370 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of MYC protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of MYC protein] CTD PMID:34910997 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO tubastatin A inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:22367689 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO tubastatin A affects the reaction [PDK1 protein affects the abundance of Cyclic AMP] CTD PMID:28887310 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions 		ISO tubastatin A results in increased expression of PTEN mRNA
[bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with tubastatin A] results in increased expression of PTEN mRNA 		CTD PMID:34910997 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO tubastatin A results in decreased phosphorylation of STAT3 protein CTD PMID:26775640 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              organonitrogen compound 19403
                organonitrogen heterocyclic compound 18546
                  pyridoindole 550
                    (14E)-11-Hydroxy-14-(1H-imidazol-5-ylmethylidene)-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                    14-epi-isochaetominine C 0
                    2,11-dimethoxy-9-(2-methylbut-3-en-2-yl)-14-propan-2-yl-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                    2-Amino-3-methyl-9H-pyrido[2,3-b]indole 10
                    2-Amino-9H-pyrido[2,3-b]indole 10
                    2-amino-9-ethyl-3-pyrido[2,3-b]indolecarboxylic acid ethyl ester 0
                    3-Amino-1-methyl-5H-pyrido[4,3-b]indole 20
                    5H-Pyrido[4,3-b]indole 0
                    9H-Pyrido[2,3-b]indole 0
                    Aniquinazoline D 0
                    Commnesin 470 0
                    Communesin A 0
                    Communesin B 0
                    Communesin C 0
                    Communesin D 0
                    Communesin E 0
                    Communesin F 0
                    Communesin G 0
                    Communesin H 0
                    Communesin I 0
                    Communesin J 0
                    Communesin K 0
                    Epi-neoxaline 0
                    Isochaetominine 0
                    Isochaetominine A 0
                    Isochaetominine B 0
                    Isochaetominine C 0
                    Isopropylchaetominine 0
                    Meleagrin C 0
                    Meleagrin D 0
                    Meleagrin E 0
                    Mescengricin 0
                    Neosartin C 0
                    Neoxaline 0
                    Sphecoline A 0
                    Sphecoline E 0
                    Sphecoline F 0
                    Sphecoline G 0
                    Trp-P-1 0
                    Versiquinazoline H 0
                    Versiquinazoline J 0
                    Versiquinazoline K 0
                    Versiquinazoline Q 0
                    alosetron + 0
                    beta-carbolines + 536
                    intoplicine 0
                    latrepirdine 0
                    pyridoindolecarboxamide + 0
                    tubastatin A 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterotricyclic compound 16078
                                      pyridoindole 550
                                        (14E)-11-Hydroxy-14-(1H-imidazol-5-ylmethylidene)-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                                        14-epi-isochaetominine C 0
                                        2,11-dimethoxy-9-(2-methylbut-3-en-2-yl)-14-propan-2-yl-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7,10-tetraene-12,15-dione 0
                                        2-Amino-3-methyl-9H-pyrido[2,3-b]indole 10
                                        2-Amino-9H-pyrido[2,3-b]indole 10
                                        2-amino-9-ethyl-3-pyrido[2,3-b]indolecarboxylic acid ethyl ester 0
                                        3-Amino-1-methyl-5H-pyrido[4,3-b]indole 20
                                        5H-Pyrido[4,3-b]indole 0
                                        9H-Pyrido[2,3-b]indole 0
                                        Aniquinazoline D 0
                                        Commnesin 470 0
                                        Communesin A 0
                                        Communesin B 0
                                        Communesin C 0
                                        Communesin D 0
                                        Communesin E 0
                                        Communesin F 0
                                        Communesin G 0
                                        Communesin H 0
                                        Communesin I 0
                                        Communesin J 0
                                        Communesin K 0
                                        Epi-neoxaline 0
                                        Isochaetominine 0
                                        Isochaetominine A 0
                                        Isochaetominine B 0
                                        Isochaetominine C 0
                                        Isopropylchaetominine 0
                                        Meleagrin C 0
                                        Meleagrin D 0
                                        Meleagrin E 0
                                        Mescengricin 0
                                        Neosartin C 0
                                        Neoxaline 0
                                        Sphecoline A 0
                                        Sphecoline E 0
                                        Sphecoline F 0
                                        Sphecoline G 0
                                        Trp-P-1 0
                                        Versiquinazoline H 0
                                        Versiquinazoline J 0
                                        Versiquinazoline K 0
                                        Versiquinazoline Q 0
                                        alosetron + 0
                                        beta-carbolines + 536
                                        intoplicine 0
                                        latrepirdine 0
                                        pyridoindolecarboxamide + 0
                                        tubastatin A 7
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