muscarinic antagonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	muscarinic antagonist	go back to main search page
Accession:	CHEBI:48876	browse the term
Definition:	A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
Synonyms:	related_synonym:	Antimuskarinika; Antimuskarinikum; agente antimuscarinico; agentes antimuscarinicos; agents antimuscariniques; antimuscarinic agents; antimuscarinicos; muscarinic acetylcholine receptor antagonist; muscarinic antagonists

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Rat (1580) Mouse (1561) Human (1575) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (1580)

(R,R)-tramadol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

Tramadol results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

decreases activity

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148

G

caspase 3

affects activity
multiple interactions
increases expression
decreases activity

Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression
multiple interactions

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase B

decreases expression
multiple interactions

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing

CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

desmin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699

G

dopamine receptor D2

increases expression

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases expression

Tramadol results in increased expression of DRD3 protein

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596

G

gap junction protein, alpha 1

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

5-hydroxytryptamine receptor 2A

increases activity
increases expression
multiple interactions

Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928

G

interferon gamma

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

lactate dehydrogenase A

decreases expression

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:64,546,225...64,579,893

G

opioid receptor, delta 1

affects binding
multiple interactions

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding
multiple interactions

Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding
multiple interactions

Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409

G

pyruvate dehydrogenase kinase 3

increases expression

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:62,480,535...62,547,371
Ensembl chr X:58,486,554...58,553,557

G

prodynorphin

decreases expression

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 2 member 4

multiple interactions

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 47 member 1

multiple interactions

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases expression
multiple interactions

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

tumor necrosis factor

multiple interactions
increases expression

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580

G

vimentin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

4-DAMP methiodide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 3

affects binding

4-DAMP methiodide inhibits response to acetylcholine in rat aortic rings

RGD

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

4-DAMP(1+)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD40 molecule

multiple interactions

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

cholinergic receptor, muscarinic 1

multiple interactions

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]

PMID:9846649 PMID:11306684

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 5

multiple interactions

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

citrate synthase

decreases activity

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421

G

dynamin 1-like

increases phosphorylation

4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased phosphorylation of DNM1L protein

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482

G

fission, mitochondrial 1

increases expression

4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased expression of FIS1 protein

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [oxotremorine M results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

mitofusin 1

decreases expression

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN1 protein

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

decreases expression

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN2 protein

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342

G

OPA1, mitochondrial dynamin like GTPase

decreases expression

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of OPA1 protein

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109

atropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065

G

acetylcholinesterase

multiple interactions

Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651

G

adenylate cyclase 5

increases response to substance

ADCY5 protein results in increased susceptibility to Atropine

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974

G

aquaporin 5

multiple interactions

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:130,721,748...130,726,209

G

BCL2 associated X, apoptosis regulator

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCAR1 scaffold protein, Cas family member

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

butyrylcholinesterase

multiple interactions

[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX

PMID:17963125 PMID:22981459

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148

G

bradykinin receptor B2

multiple interactions

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497

G

bone morphogenetic protein 6

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr13:69,125,048...69,613,795
Ensembl chr13:66,581,920...66,894,450

G

calcitonin-related polypeptide alpha

affects activity

Atropine affects the activity of CALCA protein

PMID:7906887 PMID:10075105

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105

G

caspase 3

increases expression

Atropine results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 5

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

cyclin A1

increases expression
multiple interactions

Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:139,201,074...139,243,157

G

cyclin D3

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

increases expression
multiple interactions

Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632

G

CD40 molecule

multiple interactions

Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

cell division cycle 20

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 6

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011

G

cyclin-dependent kinase 1

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

carboxylesterase 1D

multiple interactions

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035

G

cholinergic receptor, muscarinic 1

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]

PMID:16439611 PMID:18316702 PMID:31830555

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

Atropine binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein

PMID:15140916 PMID:20708676 PMID:31830555

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions
affects binding

[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]

PMID:15733544 PMID:21791372

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:15733544 PMID:21791372

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cAMP responsive element binding protein 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

multiple interactions

Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein

PMID:12039681 PMID:12906840

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919

G

catenin beta 1

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 3

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511

G

dishevelled segment polarity protein 2

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]

NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820

G

endothelin 1

multiple interactions

EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 2

multiple interactions

atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells]

RGD

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor receptor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562

G

ezrin

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EZR protein]

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II, thrombin

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:26,868,404...26,885,870

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

ghrelin and obestatin prepropeptide

multiple interactions

Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621

G

glycine receptor, alpha 1

multiple interactions

Atropine binds to and results in decreased activity of GLRA1 protein

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:39,629,459...39,727,162

G

glutamate metabotropic receptor 4

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,481,124...5,572,821

G

intercellular adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:39,945,351...40,109,124

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of KIT protein]

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652

G

lactotransferrin

multiple interactions

Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795

G

mitogen activated protein kinase 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

minichromosome maintenance complex component 4

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

increases expression
multiple interactions

Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:39,826,763...39,851,960

G

neurofilament heavy chain

affects expression

Atropine affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351

G

NLR family, pyrin domain containing 3

increases expression

Atropine results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]

PMID:15610444 PMID:16944022

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 4

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,160,445...4,184,465

G

natriuretic peptide A

affects activity

Atropine affects the activity of NPPA protein modified form

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

opioid related nociceptin receptor 1

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:168,834,003...168,839,920

G

proliferating cell nuclear antigen

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

prepronociceptin

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr15:43,800,240...43,827,841
Ensembl chr15:39,624,641...39,651,867

G

proopiomelanocortin

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]

PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783

G

paxillin

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]

NCBI chr12:46,721,546...46,768,706
Ensembl chr12:41,060,791...41,107,931

G

Rac family small GTPase 3

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]

NCBI chr10:106,002,808...106,005,243
Ensembl chr10:105,993,087...106,005,260

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein]

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746

G

solute carrier family 22 member 1

multiple interactions

Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16263091 PMID:21641380

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

PMID:16263091 PMID:21599003 PMID:23770354

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

increases uptake
multiple interactions

SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 4

multiple interactions

Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 47 member 1

multiple interactions

Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

secretory leukocyte peptidase inhibitor

increases expression

Atropine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

suppressor of cytokine signaling 3

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787

G

sialophorin

increases response to substance

SPN protein results in increased susceptibility to Atropine

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628

G

tyrosine aminotransferase

multiple interactions

[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:37,947,112...37,958,031

G

transforming growth factor, beta 1

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

trio Rho guanine nucleotide exchange factor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]

NCBI chr 2:80,235,485...80,531,824
Ensembl chr 2:78,505,070...78,803,135

G

transient receptor potential cation channel, subfamily A, member 1

decreases response to substance

TRPA1 gene mutant form results in decreased susceptibility to Atropine

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570

G

thyroid stimulating hormone subunit beta

multiple interactions

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559

G

translocator protein

multiple interactions

[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450

G

vascular cell adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

benzatropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Benztropine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

acyl-CoA thioesterase 2

increases expression

Benztropine results in increased expression of ACOT2 protein

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245

G

actin, beta-like 2

increases expression

Benztropine results in increased expression of ACTBL2 protein

NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:42,858,020...42,860,767

G

actin related protein 1A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of ACTR1A protein

NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495

G

actin related protein 3

decreases expression

Benztropine results in decreased expression of ACTR3 protein

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124

G

adenylosuccinate lyase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of ADSL protein

NCBI chr 7:114,359,440...114,383,618
Ensembl chr 7:112,479,271...112,503,760

G

alkylglycerone phosphate synthase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of AGPS protein

NCBI chr 3:81,154,599...81,253,099
Ensembl chr 3:60,747,323...60,845,830

G

adenylate kinase 1

decreases expression

Benztropine results in decreased expression of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041

G

annexin A1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

decreases expression

Benztropine results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

decreases expression

Benztropine results in decreased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,097,109...39,156,433

G

annexin A7

increases expression

Benztropine results in increased expression of ANXA7 protein

NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,821,845...3,849,385

G

acidic residue methyltransferase 1

increases expression

Benztropine results in increased expression of ARMT1 protein

NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

Benztropine results in decreased expression of ASNS protein

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423

G

aspartate-beta-hydroxylase

increases expression

Benztropine results in increased expression of ASPH protein

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:22,603,486...22,813,876

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Benztropine results in increased expression of ATP2A3 protein

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit gamma

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of ATP5F1C protein

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:68,423,909...68,608,367

G

ATPase H+ transporting V1 subunit B2

decreases expression

Benztropine results in decreased expression of ATP6V1B2 protein

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:20,617,518...20,641,745

G

ataxin 10

increases expression

Benztropine results in increased expression of ATXN10 protein

NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:116,441,613...116,565,087

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of BAZ1B protein

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BCAR1 scaffold protein, Cas family member

decreases expression

Benztropine results in decreased expression of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

bridge-like lipid transfer protein family member 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of BLTP1 protein

NCBI chr 2:119,708,114...119,924,697
Ensembl chr 2:119,708,209...119,924,695

G

bone morphogenetic protein 6

increases expression

Benztropine results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365

G

bromodomain containing 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of BRD2 protein

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388

G

basigin

decreases expression

Benztropine results in decreased expression of BSG protein

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:9,993,170...10,000,387

G

caldesmon 1

decreases expression
multiple interactions

Benztropine results in decreased expression of CALD1 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of CALD1 protein

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:63,265,942...63,446,932

G

calumenin

decreases expression

Benztropine results in decreased expression of CALU protein

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of CAMK2D protein

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178

G

cell cycle associated protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CAPRIN1 protein

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:90,153,620...90,230,502

G

caspase 8 associated protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CASP8AP2 protein

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

chromobox 5

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of CBX5 protein

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

cell division cycle and apoptosis regulator 1

increases expression

Benztropine results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 121

increases expression

Benztropine results in increased expression of CCDC121 protein

NCBI chr 6:24,970,845...24,973,451
Ensembl chr 6:24,970,833...24,973,478

G

chaperonin containing TCP1 subunit 6A

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein

NCBI chr12:32,508,842...32,519,072
Ensembl chr12:26,872,574...26,883,337

G

chaperonin containing TCP1 subunit 7

decreases expression

Benztropine results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580

G

chaperonin containing TCP1 subunit 8

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

Cd276 molecule

decreases expression

Benztropine results in decreased expression of CD276 protein

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

centromere protein V

increases expression

Benztropine results in increased expression of CENPV protein

NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,214,490...47,228,761

G

chromodomain helicase DNA binding protein 4

decreases expression

Benztropine results in decreased expression of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:157,899,391...157,931,541

G

creatine kinase B

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of CKB protein

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315

G

2',3'-cyclic nucleotide 3' phosphodiesterase

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of CNP protein
Benztropine results in decreased expression of CNP protein

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:85,511,160...85,517,720

G

collagen type XIV alpha 1 chain

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of COL14A1 protein

NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:86,722,094...86,937,214

G

collagen type V alpha 2 chain

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of COL5A2 protein

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:47,448,736...47,598,154

G

COP9 signalosome subunit 4

decreases expression

Benztropine results in decreased expression of COPS4 protein

NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887

G

coronin 1B

decreases expression

Benztropine results in decreased expression of CORO1B protein

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:201,443,014...201,448,416

G

coronin 7

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CORO7 protein

NCBI chr10:10,880,299...10,941,001
Ensembl chr10:10,885,196...10,941,001

G

copine 3

decreases expression

Benztropine results in decreased expression of CPNE3 protein

NCBI chr 5:37,811,566...37,860,840
Ensembl chr 5:33,016,307...33,063,934

G

cleavage and polyadenylation specific factor 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CPSF3 protein

NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128

G

cartilage associated protein

increases expression

Benztropine results in increased expression of CRTAP protein

NCBI chr 8:122,926,117...122,945,843
Ensembl chr 8:114,047,933...114,067,631

G

crystallin zeta

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CRYZ protein

NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:243,552,119...243,579,758

G

cold shock domain containing E1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CSDE1 protein

NCBI chr 2:193,234,546...193,271,301
Ensembl chr 2:190,554,980...190,582,784

G

cleavage stimulation factor subunit 2

decreases expression

Benztropine results in decreased expression of CSTF2 protein

NCBI chr X:101,546,809...101,572,760
Ensembl chr X:97,253,586...97,279,476

G

C-terminal binding protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CTBP1 protein

NCBI chr14:81,679,956...81,707,331
Ensembl chr14:77,455,696...77,482,821

G

cullin 2

increases expression

Benztropine results in increased expression of CUL2 protein

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

cullin 4B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of CUL4B protein

NCBI chr X:122,154,332...122,192,299
Ensembl chr X:117,287,484...117,326,688

G

aspartyl-tRNA synthetase 2 (mitochondrial)

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of DARS2 protein

NCBI chr13:75,842,078...75,870,319
Ensembl chr13:73,308,726...73,336,934

G

DAZ associated protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of DAZAP1 protein

NCBI chr 7:10,074,342...10,098,810
Ensembl chr 7:9,424,178...9,538,818

G

dynactin subunit 2

increases expression

Benztropine results in increased expression of DCTN2 protein

NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543

G

DEAD-box helicase 17

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX17 protein

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 3, X-linked

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX3X protein

NCBI chr X:12,152,346...12,165,983
Ensembl chr X:9,479,532...9,493,168

G

DiGeorge syndrome critical region gene 6

decreases expression

Benztropine results in decreased expression of DGCR6 protein

NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823

G

24-dehydrocholesterol reductase

increases expression

Benztropine results in increased expression of DHCR24 protein

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137

G

DEAH-box helicase 8

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DHX8 protein

NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137

G

dihydrolipoamide S-acetyltransferase

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of DLAT protein
Benztropine results in increased expression of DLAT protein

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

discs large MAGUK scaffold protein 2

increases expression

Benztropine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:144,451,472...146,499,475

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

Benztropine results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407

G

dipeptidylpeptidase 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of DPP3 protein

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:202,204,693...202,228,541

G

dihydropyrimidinase-like 2

decreases expression

Benztropine results in decreased expression of DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:41,005,551...41,111,829

G

dihydropyrimidinase-like 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of DPYSL3 protein

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,377,181...35,480,157

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

Benztropine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:114,376,662...114,410,934

G

EBNA1 binding protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EBNA1BP2 protein

NCBI chr 5:137,433,534...137,438,100
Ensembl chr 5:132,148,143...132,153,267

G

eukaryotic translation elongation factor 1 gamma

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EEF1G protein

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:205,860,698...205,872,382

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

Benztropine results in increased expression of EIF2S3 protein

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:58,917,490...58,940,686

G

eukaryotic translation initiation factor 3, subunit B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3B protein

NCBI chr12:19,310,308...19,334,768
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3C protein

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit H

decreases expression

Benztropine results in decreased expression of EIF3H protein

NCBI chr 7:84,980,891...85,064,284
Ensembl chr 7:83,091,039...83,174,451

G

eukaryotic translation initiation factor 3, subunit L

increases expression
multiple interactions

Benztropine results in increased expression of EIF3L protein
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3L protein

NCBI chr 7:112,522,222...112,544,063
Ensembl chr 7:110,627,107...110,663,614

G

eukaryotic translation initiation factor 5

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5 protein

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

eukaryotic translation initiation factor 5B

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein
Benztropine results in increased expression of EIF5B protein

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:40,222,898...40,277,482

G

eukaryotic translation initiation factor 6

decreases expression

Benztropine results in decreased expression of EIF6 protein

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:144,325,036...144,331,401

G

enolase 1

decreases expression

Benztropine results in decreased expression of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

Eph receptor B3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:79,840,668...79,859,370

G

Epsin 1

decreases expression

Benztropine results in decreased expression of EPN1 protein

NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

Benztropine results in decreased expression of EPS8 protein

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:170,388,378...170,486,873

G

ERH, mRNA splicing and mitosis factor

increases expression

Benztropine results in increased expression of ERH protein

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:100,280,930...100,291,210

G

ER lipid raft associated 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of ERLIN2 protein

NCBI chr16:71,720,486...71,736,999
Ensembl chr16:65,018,532...65,033,671

G

EWS RNA-binding protein 1

decreases expression

Benztropine results in decreased expression of EWSR1 protein

NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544

G

exosome component 9

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of EXOSC9 protein

NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051

G

ezrin

decreases expression

Benztropine results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 3

increases expression

Benztropine results in increased expression of FABP3 protein

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718

G

farnesyl diphosphate synthase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of FDPS protein

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776

G

flotillin 2

increases expression

Benztropine results in increased expression of FLOT2 protein

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:62,920,665...62,947,756

G

Fms related receptor tyrosine kinase 1

decreases expression

Benztropine results in decreased expression of FLT1 protein

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626

G

FYVE and coiled-coil domain autophagy adaptor 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of FYCO1 protein

NCBI chr 8:132,289,538...132,356,810
Ensembl chr 8:123,412,112...123,479,021

G

G3BP stress granule assembly factor 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of G3BP2 protein

NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548

G

glucose-6-phosphate dehydrogenase

decreases expression

Benztropine results in decreased expression of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801

G

polypeptide N-acetylgalactosaminyltransferase 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GALNT2 protein

NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:30,865,889...30,891,125

G

GATA zinc finger domain containing 2B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GATAD2B protein

NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:175,749,433...175,825,542

G

guanine deaminase

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GDA protein

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:218,906,815...218,982,416

G

glutamine fructose-6-phosphate transaminase 1

decreases expression

Benztropine results in decreased expression of GFPT1 protein

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:119,496,714...119,546,471

G

gamma-glutamyl cyclotransferase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GGCT protein

NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:84,123,118...84,129,277

G

glutaredoxin 3

increases expression

Benztropine results in increased expression of GLRX3 protein

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010

G

glutaminase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GLS protein

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900

G

G protein subunit alpha 12

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GNA12 protein

NCBI chr12:18,919,629...19,000,185
Ensembl chr12:13,805,698...13,886,255

G

golgin A4

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GOLGA4 protein

NCBI chr 8:118,208,200...118,285,003

G

golgin B1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GOLGB1 protein

NCBI chr11:77,348,573...77,406,165
Ensembl chr11:63,843,986...63,900,770

G

glutamic-oxaloacetic transaminase 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of GOT2 protein

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glucose-6-phosphate isomerase

increases expression

Benztropine results in increased expression of GPI protein

NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:86,828,216...86,856,086

G

G patch domain and KOW motifs

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GPKOW protein

NCBI chr X:17,463,521...17,478,298
Ensembl chr X:14,791,610...14,806,384

G

general transcription factor IIE subunit 1

decreases expression

Benztropine results in decreased expression of GTF2E1 protein

NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942

G

general transcription factor IIF subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GTF2F1 protein

NCBI chr 9:1,931,033...1,940,197
Ensembl chr 9:1,843,901...1,853,423

G

GTP binding protein 4

increases expression

Benztropine results in increased expression of GTPBP4 protein

NCBI chr17:65,997,472...66,019,530
Ensembl chr17:61,308,014...61,418,009

G

glycogen synthase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein

NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292

G

H2A clustered histone 20

increases expression

Benztropine results in increased expression of H2AC20 protein

NCBI chr 2:186,468,748...186,469,226

G

H2A.J histone

increases expression

Benztropine results in increased expression of H2AJ protein

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:169,675,752...169,677,006

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

Benztropine results in increased expression of HACD3 protein

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:65,501,240...65,538,507

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Benztropine results in increased expression of HADHB protein

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:26,153,578...26,184,869

G

histidyl-tRNA synthetase 1

increases expression

Benztropine results in increased expression of HARS1 protein

NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,381,655...28,398,740

G

histone acetyltransferase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of HAT1 protein

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

host cell factor C1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HCFC1 protein

NCBI chr X:156,839,100...156,864,132
Ensembl chr X:151,687,779...151,712,638

G

hemicentin 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HMCN2 protein

NCBI chr 3:14,588,353...14,738,320
Ensembl chr 3:14,588,662...14,738,025

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

Benztropine results in decreased expression of HNRNPD protein

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,615,479...9,633,786

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of HNRNPK protein

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,262,998...6,274,997

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HPS3 protein

NCBI chr 2:104,413,618...104,455,091
Ensembl chr 2:102,484,574...102,526,047

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

Benztropine results in increased expression of HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952

G

heat shock protein 90 beta family member 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of HSP90B1 protein

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Benztropine results in decreased expression of IDI1 protein

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357

G

interleukin 1 alpha

decreases expression

Benztropine results in decreased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

Benztropine results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Benztropine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487

G

junctional adhesion molecule 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:25,507,057...25,569,355

G

Jupiter microtubule associated homolog 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of JPT2 protein

NCBI chr10:14,467,652...14,487,769
Ensembl chr10:13,963,137...13,983,170

G

lysyl-tRNA synthetase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of KARS1 protein

NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Benztropine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

potassium channel tetramerization domain containing 12

decreases expression

Benztropine results in decreased expression of KCTD12 protein

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:79,801,191...79,806,282

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

Benztropine results in decreased expression of KHDRBS1 protein

NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:142,063,570...142,089,180

G

kinesin family member 5C

decreases expression

Benztropine results in decreased expression of KIF5C protein

NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:34,032,105...34,182,413

G

kelch domain containing 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of KLHDC2 protein

NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187

G

kelch-like family member 41

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of KLHL41 protein

NCBI chr 3:74,842,118...74,855,244
Ensembl chr 3:54,434,234...54,449,222

G

karyopherin subunit alpha 4

increases expression

Benztropine results in increased expression of KPNA4 protein

NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081

G

kinectin 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in increased expression of KTN1 protein
Benztropine results in decreased expression of KTN1 protein

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:20,914,642...21,002,578

G

lactamase, beta 2

increases expression

Benztropine results in increased expression of LACTB2 protein

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:5,569,067...5,596,429

G

laminin subunit beta 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of LAMB1 protein

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit gamma 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of LAMC1 protein

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:65,374,372...65,501,492

G

LIM domain and actin binding 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of LIMA1 protein

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:130,901,717...131,001,473

G

lipase A, lysosomal acid type

increases expression

Benztropine results in increased expression of LIPA protein

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633

G

leiomodin 2

increases expression

Benztropine results in increased expression of LMOD2 protein

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

lanosterol synthase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of LSS protein

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,092,774...12,118,762

G

leukotriene A4 hydrolase

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of LTA4H protein

NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600

G

LUC7-like

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of LUC7L protein

NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,273,348...15,303,112

G

MAGE family member A9

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9 protein

NCBI chr X:142,619,282...142,624,654
Ensembl chr X:142,619,395...142,624,653

G

MAGE family member D2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGED2 protein

NCBI chr X:23,160,928...23,364,994
Ensembl chr X:19,733,597...19,740,477

G

microtubule-associated protein 1S

increases expression

Benztropine results in increased expression of MAP1S protein

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,517,574...18,527,988

G

microtubule-associated protein 4

decreases expression

Benztropine results in decreased expression of MAP4 protein

NCBI chr 8:118,800,393...118,942,805
Ensembl chr 8:109,925,575...110,064,362

G

microtubule-associated protein, RP/EB family, member 1

decreases expression

Benztropine results in decreased expression of MAPRE1 protein

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:142,212,955...142,246,983

G

MARCKS-like 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein

NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817

G

methionine adenosyltransferase 2 non-catalytic beta subunit

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of MAT2B protein

NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777

G

membrane bound O-acyltransferase domain containing 7

decreases expression

Benztropine results in decreased expression of MBOAT7 protein

NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538

G

malate dehydrogenase 1

decreases expression

Benztropine results in decreased expression of MDH1 protein

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Benztropine results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

methionyl aminopeptidase 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of METAP2 protein

NCBI chr 7:30,299,433...30,327,477
Ensembl chr 7:28,411,608...28,440,434

G

macrophage migration inhibitory factor

increases expression

Benztropine results in increased expression of MIF protein

NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

metadherin

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of MTDH protein

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:65,306,400...65,364,413

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of MTHFD1L protein

NCBI chr 1:42,849,424...43,038,313
Ensembl chr 1:40,444,008...40,632,905

G

myosin heavy chain 3

increases expression

Benztropine results in increased expression of MYH3 protein

NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992

G

N-acetyltransferase 10

decreases expression

Benztropine results in decreased expression of NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:90,111,645...90,149,927

G

nuclear cap binding protein subunit 1

decreases expression

Benztropine results in decreased expression of NCBP1 protein

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:60,415,982...60,449,089

G

nectin cell adhesion molecule 2

decreases expression

Benztropine results in decreased expression of NECTIN2 protein

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:79,372,119...79,407,360

G

nicotinamide N-methyltransferase

increases expression

Benztropine results in increased expression of NNMT protein

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:48,933,598...48,946,655

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

Benztropine results in increased expression of NOC2L protein

NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:166,820,161...166,831,949

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

Benztropine results in decreased expression of NSF protein

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

NSFL1 cofactor

decreases expression

Benztropine results in decreased expression of NSFL1C protein

NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870

G

nuclear mitotic apparatus protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of NUMA1 protein

NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855

G

nucleoporin 153

increases expression

Benztropine results in increased expression of NUP153 protein

NCBI chr17:18,178,434...18,231,109
Ensembl chr17:17,972,217...18,024,876

G

nucleoporin 50

increases expression

Benztropine results in increased expression of NUP50 protein

NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905

G

nucleoporin 54

decreases expression

Benztropine results in decreased expression of NUP54 protein

NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028

G

nucleoporin 93

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of NUP93 protein

NCBI chr19:10,684,214...10,788,009
Ensembl chr19:10,682,075...10,788,026

G

nuclear RNA export factor 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of NXF1 protein

NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636

G

ornithine aminotransferase

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of OAT protein

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682

G

oxoglutarate dehydrogenase

decreases expression

Benztropine results in decreased expression of OGDH protein

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479

G

Obg-like ATPase 1

increases expression

Benztropine results in increased expression of OLA1 protein

NCBI chr 3:78,374,440...78,493,401
Ensembl chr 3:57,966,896...58,084,480

G

prolyl 4-hydroxylase subunit beta

decreases expression

Benztropine results in decreased expression of P4HB protein

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:105,836,982...105,848,500

G

proliferation-associated 2G4

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PA2G4 protein

NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:983,971...992,331

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 protein

NCBI chr10:60,031,441...60,090,259
Ensembl chr10:59,534,117...59,591,808

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

decreases expression

Benztropine results in decreased expression of PAG1 protein

NCBI chr 2:93,842,747...93,984,314
Ensembl chr 2:92,057,216...92,069,849

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein
Benztropine results in decreased expression of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

pyruvate carboxylase

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380

G

poly(rC) binding protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PCBP1 protein

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:118,972,661...118,976,500

G

poly(rC) binding protein 2

decreases expression

Benztropine results in decreased expression of PCBP2 protein

NCBI chr 7:135,483,702...135,508,254
Ensembl chr 7:133,605,573...133,629,863

G

protocadherin gamma subfamily A, 2

decreases expression

Benztropine results in decreased expression of PCDHGA2 protein

NCBI chr18:29,493,954...29,667,865
Ensembl chr18:29,493,954...29,667,868

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

decreases expression

Benztropine results in decreased expression of PCMT1 protein

NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201

G

PEST proteolytic signal containing nuclear protein

increases expression

Benztropine results in increased expression of PCNP protein

NCBI chr11:58,061,885...58,076,436
Ensembl chr11:44,592,742...44,607,348

G

phosducin-like 3

decreases expression

Benztropine results in decreased expression of PDCL3 protein

NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735

G

protein disulfide isomerase family A, member 3

decreases expression

Benztropine results in decreased expression of PDIA3 protein

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236

G

protein disulfide isomerase family A, member 6

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PDIA6 protein

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613

G

PDZ and LIM domain 5

decreases expression

Benztropine results in decreased expression of PDLIM5 protein

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:230,952,248...231,120,275

G

phosphatidylethanolamine binding protein 1

decreases expression

Benztropine results in decreased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:39,302,840...39,307,862

G

profilin 1

increases expression

Benztropine results in increased expression of PFN1 protein

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631

G

phosphoglycerate kinase 1

decreases expression

Benztropine results in decreased expression of PGK1 protein

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:71,271,440...71,287,418

G

phosphoglucomutase 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PGM3 protein

NCBI chr 8:87,518,317...87,536,021
Ensembl chr 8:87,517,701...87,536,022

G

PHD finger protein 14

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PHF14 protein

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,009,264...40,195,885

G

phosphoglycerate dehydrogenase

decreases expression

Benztropine results in decreased expression of PHGDH protein

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944

G

phosphotyrosine interaction domain containing 1

increases expression

Benztropine results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:85,284,335...85,503,044

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PIN1 protein

NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785

G

peptidase, mitochondrial processing subunit alpha

increases expression

Benztropine results in increased expression of PMPCA protein

NCBI chr 3:29,605,823...29,614,936
Ensembl chr 3:9,207,717...9,216,844

G

PNMA family member 1

increases expression

Benztropine results in increased expression of PNMA1 protein

NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567

G

PNMA family member 8A

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PNMA8A protein

NCBI chr 1:77,629,272...77,643,156
Ensembl chr 1:77,639,423...77,642,082

G

paraoxonase 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PON3 protein

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:33,349,168...33,383,855

G

inorganic pyrophosphatase 1

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of PPA1 protein
Benztropine results in increased expression of PPA1 protein

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

decreases expression

Benztropine results in decreased expression of PPM1F protein

NCBI chr11:97,568,627...97,598,613
Ensembl chr11:84,064,420...84,094,340

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of PPP1R12A protein

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:43,482,803...43,593,425

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PPP1R14B protein

NCBI chr 1:213,594,416...213,596,527
Ensembl chr 1:204,163,299...204,167,319
Ensembl chr12:204,163,299...204,167,319

G

protein phosphatase 3 catalytic subunit alpha

increases expression

Benztropine results in increased expression of PPP3CA protein

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PRKAR2A protein

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:109,395,833...109,455,628

G

PRKCSH beta subunit of glucosidase II

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of PRKCSH protein

NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:20,534,880...20,546,492

G

protein arginine methyltransferase 1

decreases expression

Benztropine results in decreased expression of PRMT1 protein

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:95,458,850...95,468,345

G

pre-mRNA processing factor 6

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of PRPF6 protein

NCBI chr 3:189,084,465...189,148,705
Ensembl chr 3:168,704,299...168,774,991

G

proteasome 20S subunit alpha 1

decreases expression

Benztropine results in decreased expression of PSMA1 protein

NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit beta 7

decreases expression

Benztropine results in decreased expression of PSMB7 protein

NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:22,354,698...22,417,937

G

proteasome 26S subunit, ATPase 1

decreases expression

Benztropine results in decreased expression of PSMC1 protein

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123

G

proteasome 26S subunit, ATPase 3

increases expression

Benztropine results in increased expression of PSMC3 protein

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, non-ATPase 7

increases expression

Benztropine results in increased expression of PSMD7 protein

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:35,494,316...35,501,588

G

Pentatricopeptide repeat domain 3

increases expression
multiple interactions

Benztropine results in increased expression of PTCD3 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of PTCD3 protein

NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538

G

prostaglandin-endoperoxide synthase 2

decreases expression

Benztropine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 7

decreases expression

Benztropine results in decreased expression of PTK7 protein

NCBI chr 9:21,849,756...21,916,077
Ensembl chr 9:14,351,202...14,418,494

G

poly-U binding splicing factor 60

decreases expression

Benztropine results in decreased expression of PUF60 protein

NCBI chr 7:109,663,490...109,674,443
Ensembl chr 7:107,782,770...107,794,531

G

PWP2, small subunit processome component

increases expression

Benztropine results in increased expression of PWP2 protein

NCBI chr20:10,498,998...10,512,631
Ensembl chr20:10,499,363...10,513,640

G

pyrroline-5-carboxylate reductase 1

increases expression

Benztropine results in increased expression of PYCR1 protein

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:105,917,680...105,922,549

G

quinoid dihydropteridine reductase

decreases expression

Benztropine results in decreased expression of QDPR protein

NCBI chr14:69,882,776...69,896,378
Ensembl chr14:65,670,131...65,683,854

G

receptor for activated C kinase 1

decreases expression

Benztropine results in decreased expression of RACK1 protein

NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,169,169...33,174,975

G

RNA binding motif protein 15

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of RBM15 protein

NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703

G

RIC8 guanine nucleotide exchange factor A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of RIC8A protein

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:195,935,349...195,941,467

G

ribosomal protein L10A

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL10A protein

NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L19

increases expression

Benztropine results in increased expression of RPL19 protein

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,019,257...83,052,112

G

ribosomal protein L24

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL24 protein

NCBI chr11:58,122,997...58,128,405
Ensembl chr11:44,653,937...44,659,370

G

ribosomal protein L30

increases expression

Benztropine results in increased expression of RPL30 protein

NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363
Ensembl chr 1:65,645,991...65,651,363

G

ribosomal protein L7A

decreases expression

Benztropine results in decreased expression of RPL7A protein

NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:10,239,001...10,241,716
Ensembl chr18:10,239,001...10,241,716

G

ribosomal protein lateral stalk subunit P1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPLP1 protein

NCBI chr 8:71,289,539...71,290,872
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein S12

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS12 protein

NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:21,680,852...21,683,014

G

ribosomal protein S18

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS18 protein

NCBI chr20:4,931,427...4,935,538
Ensembl chr20:4,931,768...4,938,315

G

ribosomal protein S27

increases expression

Benztropine results in increased expression of RPS27 protein

NCBI chr 2:177,963,499...177,964,708
Ensembl chr 2:175,665,853...175,666,964
Ensembl chr12:175,665,853...175,666,964

G

ribosomal protein S27a

increases expression

Benztropine results in increased expression of RPS27A protein

NCBI chr14:107,486,664...107,488,941
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S3

decreases expression

Benztropine results in decreased expression of RPS3 protein

NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:153,777,472...153,783,680

G

RuvB-like AAA ATPase 2

increases expression

Benztropine results in increased expression of RUVBL2 protein

NCBI chr 1:105,038,487...105,051,851
Ensembl chr 1:95,901,701...95,915,342

G

SUMO1 activating enzyme subunit 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SAE1 protein

NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986

G

seryl-tRNA synthetase 1

decreases expression

Benztropine results in decreased expression of SARS1 protein

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:196,065,430...196,081,277

G

SATB homeobox 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SATB2 protein

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:58,350,246...58,530,707

G

saccharopine dehydrogenase (putative)

decreases expression

Benztropine results in decreased expression of SCCPDH protein

NCBI chr13:91,400,120...91,421,875
Ensembl chr13:91,400,190...91,422,222

G

syndecan binding protein

decreases expression

Benztropine results in decreased expression of SDCBP protein

NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:19,489,961...19,527,572

G

Sec23 homolog A, COPII coat complex component

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SEC23A protein

NCBI chr 6:82,393,699...82,442,594
Ensembl chr 6:76,658,427...76,706,035

G

SEC61 translocon subunit beta

increases expression

Benztropine results in increased expression of SEC61B protein

NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:61,773,594...61,781,804

G

SEC63 homolog, protein translocation regulator

increases expression

Benztropine results in increased expression of SEC63 protein

NCBI chr20:47,827,291...47,896,248
Ensembl chr20:46,245,101...46,314,055

G

Serpine1 mRNA binding protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SERBP1 protein

NCBI chr 4:97,731,200...97,748,438
Ensembl chr 4:96,401,477...96,421,813

G

serpin family B member 3A

increases expression

Benztropine results in increased expression of SERPINB4 protein

NCBI chr13:23,755,690...23,766,188
Ensembl chr13:23,236,972...23,246,985

G

splicing factor 1

decreases expression

Benztropine results in decreased expression of SF1 protein

NCBI chr 1:213,090,256...213,112,688
Ensembl chr 1:203,670,018...203,684,330

G

splicing factor 3b, subunit 3

decreases expression

Benztropine results in decreased expression of SF3B3 protein

NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245

G

sarcoglycan, alpha

decreases expression

Benztropine results in decreased expression of SGCA protein

NCBI chr10:80,397,158...80,416,165
Ensembl chr10:79,908,738...79,922,813

G

SH3 and PX domains 2B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SH3PXD2B protein

NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170

G

serine hydroxymethyltransferase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SHMT1 protein

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820

G

solute carrier family 22 member 2

multiple interactions

Benztropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 25 member 5, pseudogene 11

increases expression

Benztropine results in increased expression of SLC25A6 protein

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:68,571,300...68,572,199

G

solute carrier family 2 member 1

decreases expression

Benztropine results in decreased expression of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 38, member 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SLC38A2 protein

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 3 member 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of SLC3A2 protein

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 6 member 3

multiple interactions

Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413

G

secretory leukocyte peptidase inhibitor

increases expression

Benztropine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

Benztropine results in decreased expression of SMARCB1 protein

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,741,477...12,763,620

G

structural maintenance of chromosomes 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SMC3 protein

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:252,601,753...252,644,522

G

SMU1, DNA replication regulator and spliceosomal factor

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SMU1 protein

NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300

G

small nuclear ribonucleoprotein U5 subunit 200

multiple interactions
increases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of SNRNP200 protein
Benztropine results in increased expression of SNRNP200 protein

NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182

G

small nuclear ribonucleoprotein polypeptide A

increases expression

Benztropine results in increased expression of SNRPA protein

NCBI chr 1:91,609,419...91,618,119
Ensembl chr 1:82,481,770...82,490,538

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

Benztropine results in increased expression of SNRPD2 protein

NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:78,798,377...78,803,351
Ensembl chr20:78,798,377...78,803,351

G

splicing regulatory glutamic acid and lysine rich protein 1

decreases expression

Benztropine results in decreased expression of SREK1 protein

NCBI chr 2:34,849,548...34,885,120
Ensembl chr 2:34,852,458...34,884,972

G

serine and arginine rich splicing factor 5

increases expression

Benztropine results in increased expression of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:100,605,456...100,610,177

G

signal transducer and activator of transcription 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

stromal interaction molecule 1

decreases expression

Benztropine results in decreased expression of STIM1 protein

NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:156,656,013...156,818,363

G

stress-induced phosphoprotein 1

decreases expression

Benztropine results in decreased expression of STIP1 protein

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476

G

serine/threonine kinase receptor associated protein

decreases expression

Benztropine results in decreased expression of STRAP protein

NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:170,646,001...170,660,828

G

STIP1 homology and U-box containing protein 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of STUB1 protein

NCBI chr10:15,355,278...15,357,559
Ensembl chr10:14,850,765...14,853,046

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

Benztropine results in decreased expression of SUCLG1 protein

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:105,308,039...105,337,600

G

small ubiquitin-like modifier 2

decreases expression

Benztropine results in decreased expression of SUMO2 protein

NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513
Ensembl chr 5:100,686,797...100,784,513

G

Sad1 and UNC84 domain containing 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of SUN1 protein

NCBI chr12:20,510,230...20,555,123
Ensembl chr12:15,396,381...15,441,571

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

Benztropine results in decreased expression of SYNCRIP protein

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:89,402,866...89,435,515

G

transgelin 2

decreases expression

Benztropine results in decreased expression of TAGLN2 protein

NCBI chr13:87,499,350...87,506,328
Ensembl chr13:84,967,009...84,973,972

G

tubulin folding cofactor B

decreases expression

Benztropine results in decreased expression of TBCB protein

NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:85,477,640...85,483,488

G

TRPM8 channel-associated factor 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of TCAF1 protein
Benztropine results in decreased expression of TCAF1 protein

NCBI chr 4:72,589,710...72,639,304
Ensembl chr 4:71,591,200...71,613,309

G

trans-golgi network protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of TGOLN2 protein

NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:104,663,353...104,671,164

G

talin 2

decreases expression

Benztropine results in decreased expression of TLN2 protein

NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219

G

thymopoietin

decreases expression

Benztropine results in decreased expression of TMPO protein

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:25,586,725...25,667,727

G

tankyrase 1 binding protein 1

multiple interactions
decreases expression

[Cuprizone co-treated with Benztropine] results in decreased expression of TNKS1BP1 protein
Benztropine results in decreased expression of TNKS1BP1 protein

NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038

G

translocase of outer mitochondrial membrane 34

decreases expression
multiple interactions

Benztropine results in decreased expression of TOMM34 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TOMM34 protein

NCBI chr 3:173,148,737...173,165,689
Ensembl chr 3:152,729,349...152,746,373

G

DNA topoisomerase I mitochondrial

increases expression

Benztropine results in increased expression of TOP1MT protein

NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:107,342,527...107,366,049

G

tropomyosin 2

decreases expression

Benztropine results in decreased expression of TPM2 protein

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

tropomyosin 3

decreases expression

Benztropine results in decreased expression of TPM3 protein

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013

G

translocated promoter region, nuclear basket protein

decreases expression

Benztropine results in decreased expression of TPR protein

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:62,424,312...62,487,496

G

tripartite motif-containing 28

decreases expression
multiple interactions

Benztropine results in decreased expression of TRIM28 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TRIM28 protein

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:73,652,709...73,659,380

G

tetraspanin 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of TSPAN3 protein

NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880

G

tetratricopeptide repeat domain 21A

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of TTC21A protein

NCBI chr 8:128,544,684...128,580,464
Ensembl chr 8:119,666,933...119,702,456

G

tweety family member 2

increases expression

Benztropine results in increased expression of TTYH2 protein

NCBI chr10:100,208,129...100,252,505
Ensembl chr10:99,709,007...99,753,444

G

tweety family member 3

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of TTYH3 protein

NCBI chr12:19,110,973...19,139,379
Ensembl chr12:13,997,045...14,025,459

G

tubulin, beta 5 class I

increases expression

Benztropine results in increased expression of TUBB protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940

G

twinfilin actin-binding protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of TWF2 protein

NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:106,845,253...106,858,298

G

taxilin alpha

decreases expression

Benztropine results in decreased expression of TXLNA protein

NCBI chr 5:147,253,694...147,269,410
Ensembl chr 5:141,969,346...141,984,583

G

thymidylate synthetase

increases expression

Benztropine results in increased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536

G

U2 small nuclear RNA auxiliary factor 2

decreases expression

Benztropine results in decreased expression of U2AF2 protein

NCBI chr 1:77,789,752...77,807,307
Ensembl chr 1:68,760,924...68,778,492

G

ubiquitin-like modifier activating enzyme 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of UBA2 protein

NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:86,775,244...86,802,682

G

ubiquitin associated protein 2-like

decreases expression

Benztropine results in decreased expression of UBAP2L protein

NCBI chr 2:177,736,378...177,791,746
Ensembl chr 2:175,438,703...175,493,998

G

ubiquitin C

increases expression

Benztropine results in increased expression of UBC protein

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925

G

ubiquilin 2

decreases expression

Benztropine results in decreased expression of UBQLN2 protein

NCBI chr X:21,228,809...21,232,228
Ensembl chr X:17,853,114...17,856,505

G

ubiquitin C-terminal hydrolase L1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of UCHL1 protein

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590

G

ubiquitin C-terminal hydrolase L3

decreases expression

Benztropine results in decreased expression of UCHL3 protein

NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
Ensembl chr 3:78,485,315...78,527,355

G

UDP-glucose 6-dehydrogenase

decreases expression

Benztropine results in decreased expression of UGDH protein

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354

G

unc-45 myosin chaperone B

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of UNC45B protein

NCBI chr10:67,845,464...67,873,143
Ensembl chr10:67,845,462...67,873,389

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of UQCRC2 protein

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453

G

USO1 vesicle transport factor

decreases expression

Benztropine results in decreased expression of USO1 protein

NCBI chr14:16,150,921...16,216,389
Ensembl chr14:15,866,638...15,932,171

G

ubiquitin specific peptidase 10

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of USP10 protein

NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897

G

ubiquitin specific peptidase 14

increases expression

Benztropine results in increased expression of USP14 protein

NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519

G

UTP18 small subunit processome component

increases expression

Benztropine results in increased expression of UTP18 protein

NCBI chr10:79,308,785...79,336,241
Ensembl chr10:78,811,880...78,839,627

G

vasodilator-stimulated phosphoprotein

decreases expression

Benztropine results in decreased expression of VASP protein

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:78,910,011...78,925,061

G

tryptophanyl-tRNA synthetase 1

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of WARS1 protein

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat domain 12

decreases expression

Benztropine results in decreased expression of WDR12 protein

NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:61,475,517...61,502,469

G

xin actin-binding repeat containing 2

decreases expression

Benztropine results in decreased expression of XIRP2 protein

NCBI chr 3:72,534,175...72,621,056
Ensembl chr 3:51,870,092...52,213,091

G

exportin 7

multiple interactions

[Cuprizone co-treated with Benztropine] results in increased expression of XPO7 protein

NCBI chr15:45,742,053...45,828,050
Ensembl chr15:45,742,053...45,828,050

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

increases expression

Benztropine results in increased expression of YWHAQ protein

NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:40,935,949...40,966,273

G

zinc finger and BTB domain containing 42

multiple interactions

[Cuprizone co-treated with Benztropine] results in decreased expression of ZBTB42 protein

NCBI chr 6:137,559,622...137,561,750
Ensembl chr 6:131,738,356...131,742,685

G

zinc finger RNA binding protein

decreases expression

Benztropine results in decreased expression of ZFR protein

NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:61,137,611...61,200,322

G

zinc finger with KRAB and SCAN domains 7

decreases expression

Benztropine results in decreased expression of ZKSCAN7 protein

NCBI chr 8:131,379,514...131,397,065
Ensembl chr 8:122,502,218...122,519,600

biperiden

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Biperiden results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

bone morphogenetic protein 6

increases expression

Biperiden results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365

G

cholinergic receptor, muscarinic 1

multiple interactions

Biperiden binds to and results in decreased activity of CHRM1 protein

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

epiregulin

increases expression

Biperiden results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,027,287...17,041,062

G

interleukin 1 alpha

increases expression

Biperiden results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Biperiden results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Biperiden results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Biperiden results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

phosphotyrosine interaction domain containing 1

increases expression

Biperiden results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:85,284,335...85,503,044

G

solute carrier family 7 member 11

increases expression

Biperiden results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

butylscopolamine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

carbinoxamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

carbinoxamine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

cinnarizine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

Cinnarizine results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

dopamine receptor D2

affects binding
multiple interactions

Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]

PMID:7503767 PMID:11180191

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

parkin RBR E3 ubiquitin protein ligase

decreases response to substance

PRKN results in decreased susceptibility to Cinnarizine

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555

clemastine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Clemastine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

histamine receptor H 1

multiple interactions

Clemastine binds to and results in decreased activity of HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Clemastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

clozapine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of AARS1 protein

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

decreases activity

Clozapine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein

PMID:9111066 PMID:16810505

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily E member 1

increases expression

Clozapine results in increased expression of ABCE1 protein

NCBI chr19:45,109,880...45,134,819
Ensembl chr19:28,205,555...28,230,489

G

ATP binding cassette subfamily G member 1

increases expression

Clozapine results in increased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions

Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409

G

actin binding LIM protein family, member 2

increases expression

Clozapine results in increased expression of ABLIM2 mRNA

NCBI chr14:79,090,046...79,214,986
Ensembl chr14:74,866,281...74,990,334

G

acetyl-CoA acetyltransferase 2

increases expression

Clozapine results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA thioesterase 2

increases expression

Clozapine results in increased expression of ACOT2 protein

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 7

decreases expression

Clozapine results in decreased expression of ACOT7 protein

NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA oxidase 1

multiple interactions

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232

G

actin, beta

decreases expression

Clozapine results in decreased expression of ACTB protein

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877

G

actin, beta-like 2

increases expression

Clozapine results in increased expression of ACTBL2 protein

NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:42,858,020...42,860,767

G

actin related protein 3

decreases expression

Clozapine results in decreased expression of ACTR3 protein

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124

G

actin related protein 5

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein

NCBI chr 3:147,282,461...147,295,870
Ensembl chr 3:147,282,624...147,296,110

G

ADAM metallopeptidase domain 1a

decreases expression

Clozapine results in decreased expression of ADAM1A mRNA

NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

adenylate cyclase 5

affects response to substance
multiple interactions

ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin, C1Q and collagen domain containing

decreases expression
increases expression
multiple interactions

Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]

PMID:17933447 PMID:18162013 PMID:20564506

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

adenosine A2a receptor

decreases expression

Clozapine results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 1A

multiple interactions

Clozapine binds to and results in decreased activity of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500

G

1-acylglycerol-3-phosphate O-acyltransferase 1

decreases expression

Clozapine results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278

G

angiotensinogen

multiple interactions

Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

Clozapine results in increased expression of AIMP1 protein

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 1

decreases expression

Clozapine results in decreased expression of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041

G

AKT serine/threonine kinase 1

increases expression
decreases expression
increases phosphorylation

Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein

PMID:15860345 PMID:19440698

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

increases expression

Clozapine results in increased expression of AKT2 mRNA

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817

G

albumin

multiple interactions
affects binding

Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Clozapine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

increases expression

Clozapine results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate B

increases expression
decreases expression

Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein

PMID:34122009 PMID:36482696

NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA

PMID:15860345 PMID:16465460

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066

G

alkaline phosphatase, placental

multiple interactions

Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:87,765,860...87,768,606

G

Aly/REF export factor

decreases expression

Clozapine results in decreased expression of ALYREF protein

NCBI chr10:106,369,750...106,373,395
Ensembl chr10:105,871,306...105,875,069

G

annexin A1

decreases expression

Clozapine results in decreased expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

decreases expression

Clozapine results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

decreases expression

Clozapine results in decreased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,097,109...39,156,433

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Clozapine results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 2 subunit beta 1

increases expression

Clozapine results in increased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

adaptor related protein complex 3 subunit beta 1

increases expression

Clozapine results in increased expression of AP3B1 protein

NCBI chr 2:27,331,241...27,535,683
Ensembl chr 2:25,600,040...25,800,935

G

apolipoprotein A5

affects response to substance

APOA5 gene polymorphism affects the susceptibility to Clozapine

NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein D

increases expression

Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein

PMID:11158250 PMID:14647396 PMID:17266109

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

increases expression

Clozapine results in increased expression of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

decreases expression

Clozapine results in decreased expression of ARC mRNA

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378

G

Cdc42 guanine nucleotide exchange factor 9

decreases expression

Clozapine results in decreased expression of ARHGEF9 mRNA

NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513

G

ARF like GTPase 8A

decreases expression

Clozapine results in decreased expression of ARL8A protein

NCBI chr13:49,137,632...49,146,633
Ensembl chr13:46,585,845...46,594,851

G

acidic residue methyltransferase 1

increases expression

Clozapine results in increased expression of ARMT1 protein

NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302

G

actin related protein 2/3 complex, subunit 4

affects expression

Clozapine affects the expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:146,522,176...146,532,785

G

N-acylsphingosine amidohydrolase 1

increases expression

Clozapine results in increased expression of ASAH1 mRNA

PMID:15342952 PMID:17175557

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein

PMID:15342952 PMID:17175557 PMID:36482696

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423

G

aspartate-beta-hydroxylase

increases expression

Clozapine results in increased expression of ASPH protein

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:22,603,486...22,813,876

G

argininosuccinate synthase 1

increases expression

Clozapine results in increased expression of ASS1 protein

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903

G

ATPase family, AAA domain containing 3A

decreases expression

Clozapine results in decreased expression of ATAD3A protein

NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:166,350,304...166,370,482

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Clozapine results in increased expression of ATP2A3 protein

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit beta

decreases expression

Clozapine results in decreased expression of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Clozapine results in increased expression of ATP5PB protein

NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:193,424,047...193,435,418

G

ATPase H+ transporting V1 subunit A

decreases expression

Clozapine results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B1

decreases expression

Clozapine results in decreased expression of ATP6V1B1 protein

NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475

G

ATPase H+ transporting V1 subunit B2

decreases expression

Clozapine results in decreased expression of ATP6V1B2 protein

PMID:19441803 PMID:34122009

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:20,617,518...20,641,745

G

ataxin 10

increases expression

Clozapine results in increased expression of ATXN10 protein

NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:116,441,613...116,565,087

G

axin 2

decreases expression

Clozapine results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

beta-secretase 2

increases expression

Clozapine results in increased expression of BACE2 protein

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
decreases expression

Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein

PMID:16160616 PMID:17069804

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BCAR1 scaffold protein, Cas family member

decreases expression

Clozapine results in decreased expression of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2, apoptosis regulator

increases expression

Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 14

decreases expression

Clozapine results in decreased expression of BCL2L14 protein

NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086

G

brain-derived neurotrophic factor

decreases expression
increases expression

Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein

PMID:11488957 PMID:12478621 PMID:17442489

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

Bet1 golgi vesicular membrane trafficking protein-like

decreases expression

Clozapine results in decreased expression of BET1L mRNA

NCBI chr 1:205,361,041...205,365,036
Ensembl chr 1:195,931,411...195,935,040

G

BCL2-interacting killer

multiple interactions
increases expression

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296

G

bromodomain PHD finger transcription factor

decreases expression

Clozapine results in decreased expression of BPTF mRNA

NCBI chr10:92,480,007...92,582,485
Ensembl chr10:91,982,758...92,082,769

G

basic leucine zipper and W2 domains 1

increases expression

Clozapine results in increased expression of BZW1 protein

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

calcium voltage-gated channel subunit alpha1 A

decreases expression

Clozapine results in decreased expression of CACNA1A mRNA

PMID:14647396 PMID:16715494

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225

G

calcium binding and coiled coil domain 1

increases expression

Clozapine results in increased expression of CALCOCO1 protein

NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:133,834,707...133,849,422

G

calmodulin 2

increases expression

Clozapine results in increased expression of CALM2 mRNA

NCBI chr 6:12,845,170...12,857,830
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calreticulin

decreases expression

Clozapine results in decreased expression of CALR protein

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

calumenin

decreases expression

Clozapine results in decreased expression of CALU protein

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression
increases expression

Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein

PMID:15860345 PMID:17266109 PMID:19289156

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

Clozapine results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Clozapine results in decreased expression of CAMK2D mRNA

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase IV

increases expression
decreases expression

Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein

PMID:15860345 PMID:19289156

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

Clozapine results in decreased expression of CAMKK1 protein

NCBI chr10:58,135,872...58,159,023
Ensembl chr10:57,637,391...57,660,498

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

Clozapine results in decreased expression of CAMKK2 protein

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279

G

calnexin

decreases expression

Clozapine results in decreased expression of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821

G

cysteinyl-tRNA synthetase 1

increases expression

Clozapine results in increased expression of CARS1 protein

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:198,753,691...198,795,941

G

CART prepropeptide

decreases expression

Clozapine results in decreased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713

G

caspase 1

increases activity

Clozapine results in increased activity of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
multiple interactions

Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]

PMID:22700542 PMID:24709159

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle and apoptosis regulator 1

increases expression

Clozapine results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 47

increases expression
multiple interactions

Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein

NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881

G

cholecystokinin

multiple interactions
increases expression

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA

PMID:10974607 PMID:16567023

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

increases expression

Clozapine results in increased expression of CCKBR mRNA

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 1

decreases expression

Clozapine results in decreased expression of CCL1 mRNA

NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,128,331...67,131,159

G

cyclin D1

decreases expression

Clozapine results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

increases expression

Clozapine results in increased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371

G

cyclin L1

increases expression

Clozapine results in increased expression of CCNL1 mRNA

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

chaperonin containing TCP1 subunit 7

decreases expression

Clozapine results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580

G

Cd276 molecule

decreases expression

Clozapine results in decreased expression of CD276 protein

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

Cd63 molecule

increases expression

Clozapine results in increased expression of CD63 protein

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

increases expression

Clozapine results in increased expression of CDIPT protein

NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:181,583,141...181,587,408

G

cyclin-dependent kinase 4

increases expression

Clozapine results in increased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

increases expression

Clozapine results in increased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Clozapine results in increased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein V

increases expression

Clozapine results in increased expression of CENPV protein

NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,214,490...47,228,761

G

cilia and flagella associated protein 210

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein

NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607

G

coiled-coil-helix-coiled-coil-helix domain containing 2

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein

NCBI chr12:32,464,847...32,470,871
Ensembl chr12:26,828,736...26,834,755

G

chromodomain helicase DNA binding protein 4

decreases expression

Clozapine results in decreased expression of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:157,899,391...157,931,541

G

chromogranin A

decreases expression
increases expression

Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA

NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398

G

cell adhesion molecule L1-like

decreases expression

Clozapine results in decreased expression of CHL1 mRNA

NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:136,291,463...136,503,265

G

chimerin 1

decreases expression

Clozapine results in decreased expression of CHN1 mRNA

NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:58,510,536...58,676,490

G

cysteine and histidine rich domain containing 1

increases expression

Clozapine results in increased expression of CHORDC1 protein

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cholinergic receptor, muscarinic 1

affects binding
increases expression
multiple interactions

Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]

PMID:11997696 PMID:16983399 PMID:18806925

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cytoskeleton-associated protein 4

increases expression

Clozapine results in increased expression of CKAP4 protein

NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914

G

chloride intracellular channel 1

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein

NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,761,461...3,773,712

G

chloride intracellular channel 4

increases expression

Clozapine results in increased expression of CLIC4 protein

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:147,453,712...147,513,452

G

clock circadian regulator

affects response to substance

CLOCK gene SNP affects the susceptibility to Clozapine

NCBI chr14:32,262,747...32,346,872
Ensembl chr14:31,908,566...31,990,400

G

clathrin, light chain A

decreases expression

Clozapine results in decreased expression of CLTA mRNA

NCBI chr 5:63,022,046...63,059,223
Ensembl chr 5:58,245,442...58,263,472

G

clathrin, light chain B

decreases expression

Clozapine results in decreased expression of CLTB mRNA

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,001,513...10,019,169

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression
increases expression

Clozapine results in decreased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein
Clozapine results in increased expression of CNP mRNA

PMID:17266109 PMID:34122009

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:85,511,160...85,517,720

G

coilin

increases expression

Clozapine results in increased expression of COIL mRNA

NCBI chr10:74,286,279...74,307,597
Ensembl chr10:73,789,488...73,810,393

G

collagen type V alpha 2 chain

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:47,448,736...47,598,154

G

catechol-O-methyltransferase

multiple interactions
affects response to substance
increases response to substance

[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine

PMID:15190105 PMID:17123785

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

COP9 signalosome subunit 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein

NCBI chr10:45,117,664...45,151,868
Ensembl chr10:44,618,115...44,641,597

G

coronin 1B

decreases expression

Clozapine results in decreased expression of CORO1B protein

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:201,443,014...201,448,416

G

complexin 2

decreases expression

Clozapine results in decreased expression of CPLX2 mRNA

NCBI chr17:10,224,673...10,297,974
Ensembl chr17:10,222,347...10,293,855

G

carboxypeptidase N subunit 1

increases expression

Clozapine results in increased expression of CPN1 mRNA

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

copine 1

decreases expression

Clozapine results in decreased expression of CPNE1 protein

NCBI chr 3:165,047,615...165,089,994
Ensembl chr 3:144,588,995...144,598,636

G

carnitine palmitoyltransferase 2

multiple interactions

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

decreases expression

Clozapine results in decreased expression of CRH mRNA

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone binding protein

decreases expression

Clozapine results in decreased expression of CRHBP mRNA

NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:26,692,403...26,704,710

G

C-reactive protein

increases expression

Clozapine results in increased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 3

multiple interactions

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 2 alpha 1

decreases expression

Clozapine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:140,709,991...140,756,696

G

cystatin C

increases expression

Clozapine results in increased expression of CST3 mRNA

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822

G

cleavage stimulation factor subunit 1

decreases expression

Clozapine results in decreased expression of CSTF1 protein

NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300

G

cleavage stimulation factor subunit 2

decreases expression

Clozapine results in decreased expression of CSTF2 protein

NCBI chr X:101,546,809...101,572,760
Ensembl chr X:97,253,586...97,279,476

G

C-terminal binding protein 1

increases expression

Clozapine results in increased expression of CTBP1 protein

NCBI chr14:81,679,956...81,707,331
Ensembl chr14:77,455,696...77,482,821

G

catenin beta 1

increases expression
multiple interactions

Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

chymotrypsin-like

increases expression

Clozapine results in increased expression of CTRL mRNA

NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626

G

cathepsin K

increases expression

Clozapine results in increased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550

G

cortactin

increases expression

Clozapine results in increased expression of CTTN protein

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:199,599,710...199,635,164

G

cullin 2

increases expression

Clozapine results in increased expression of CUL2 protein

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

cullin 3

increases expression

Clozapine results in increased expression of CUL3 protein

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462

G

C-X-C motif chemokine ligand 1

decreases expression
decreases secretion
multiple interactions
increases secretion

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]

PMID:17346280 PMID:34935985 PMID:36482696

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases secretion

Clozapine results in decreased secretion of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

decreases expression
decreases secretion

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein

PMID:17346280 PMID:36482696

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511

G

similar to human chromosome X open reading frame 49

increases expression

Clozapine results in increased expression of CXORF49 protein

NCBI chr X:66,911,430...66,915,407
Ensembl chr X:66,911,431...66,915,293

G

cytochrome b5 type B

increases expression

Clozapine results in increased expression of CYB5B mRNA

NCBI chr19:51,972,611...52,006,477
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b5 reductase 1

increases expression

Clozapine results in increased expression of CYB5R1 protein

NCBI chr13:48,401,061...48,407,466
Ensembl chr13:45,849,091...45,855,458

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases metabolic processing

Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Clozapine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Clozapine

PMID:18493746 PMID:18809730 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing

CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine

PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases metabolic processing
decreases activity

CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein

PMID:18809730 PMID:33814510

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases metabolic processing

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing

CYP2C8 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
increases metabolic processing
multiple interactions

CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine

PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases metabolic processing

CYP2J2 protein results in increased metabolism of Clozapine

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
affects metabolic processing
multiple interactions

CYP3A4 protein results in increased metabolism of Clozapine
CYP3A4 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

CYP3A5 protein results in increased metabolism of Clozapine

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

DAB adaptor protein 1

increases expression

Clozapine results in increased expression of DAB1 mRNA

NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:119,140,533...119,510,552

G

DAB adaptor protein 2

increases expression

Clozapine results in increased expression of DAB2 protein

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476

G

diacylglycerol lipase, beta

increases expression

Clozapine results in increased expression of DAGLB protein

NCBI chr12:16,173,345...16,215,777
Ensembl chr12:11,059,732...11,102,154

G

DDB1 and CUL4 associated factor 6

decreases expression

Clozapine results in decreased expression of DCAF6 mRNA

NCBI chr13:80,159,282...80,260,510
Ensembl chr13:77,626,307...77,727,512

G

doublecortin-like kinase 1

increases expression

Clozapine results in increased expression of DCLK1 mRNA

PMID:15860345 PMID:18797397

NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:139,417,163...139,710,956

G

dopa decarboxylase

multiple interactions
increases expression

Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208

G

DEAD-box helicase 46

increases expression

Clozapine results in increased expression of DDX46 protein

NCBI chr17:8,947,237...8,993,705
Ensembl chr17:8,944,454...8,988,439

G

DENN domain containing 10

increases expression

Clozapine results in increased expression of DENND10 mRNA

NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455

G

DEPP autophagy regulator 1

increases expression

Clozapine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:149,910,779...149,914,542

G

DiGeorge syndrome critical region gene 6

decreases expression

Clozapine results in decreased expression of DGCR6 protein

NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823

G

diacylglycerol kinase, alpha

decreases expression

Clozapine results in decreased expression of DGKA mRNA

NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,148,735...1,175,110

G

24-dehydrocholesterol reductase

increases expression

Clozapine results in increased expression of DHCR24 protein

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

increases expression

Clozapine results in increased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:199,015,081...199,031,055

G

DExH-box helicase 30

increases expression

Clozapine results in increased expression of DHX30 protein

NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:110,064,752...110,097,381

G

DEAH-box helicase 38

decreases expression

Clozapine results in decreased expression of DHX38 protein

NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140

G

DISC1 scaffold protein

decreases response to substance
affects response to substance

DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine

NCBI chr19:69,911,548...70,120,970
Ensembl chr19:53,014,616...53,219,778

G

dihydrolipoamide S-acetyltransferase

decreases expression
increases expression

Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein

PMID:15860345 PMID:34122009

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

discs large MAGUK scaffold protein 2

increases expression

Clozapine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:144,451,472...146,499,475

G

dihydrolipoamide S-succinyltransferase

decreases expression

Clozapine results in decreased expression of DLST protein

NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:104,758,631...104,783,296

G

dynein, axonemal, heavy chain 11

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein

NCBI chr 6:144,982,130...145,298,523
Ensembl chr 6:138,839,177...139,155,536

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

Clozapine results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407

G

double PHD fingers 1

affects expression

Clozapine affects the expression of DPF1 mRNA

NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:84,602,336...84,615,950

G

dipeptidylpeptidase 3

multiple interactions

[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:202,204,693...202,228,541

G

dihydropyrimidinase-like 3

decreases expression

Clozapine results in decreased expression of DPYSL3 protein

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,377,181...35,480,157

G

dihydropyrimidinase-like 4

decreases expression

Clozapine results in decreased expression of DPYSL4 protein

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:193,883,106...193,898,914

G

down-regulator of transcription 1

decreases expression

Clozapine results in decreased expression of DR1 protein

NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,458,223...1,469,638

G

dopamine receptor D1

affects binding
decreases expression
affects response to substance

Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance

[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More...

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

affects response to substance
multiple interactions
decreases response to substance

DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine

PMID:15579174 PMID:20029384

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

affects binding
multiple interactions
affects response to substance

Clozapine binds to DRD4 protein
Clozapine binds to Drd4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine

CTD
RGD

PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:196,396,366...196,399,553

G

dystrophin related protein 2

increases expression

Clozapine results in increased expression of DRP2 mRNA alternative form

NCBI chr X:101,900,743...101,951,403
Ensembl chr X:97,607,719...97,655,684

G

dystrobrevin binding protein 1

increases response to substance
affects response to substance

DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine

NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661

G

dual specificity phosphatase 1

decreases expression

Clozapine results in decreased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

dual specificity phosphatase 6

decreases expression

Clozapine results in decreased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185

G

dishevelled segment polarity protein 3

increases expression
multiple interactions

Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]

NCBI chr11:93,869,834...93,887,013
Ensembl chr11:80,366,117...80,382,462

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

Clozapine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:114,376,662...114,410,934

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

Clozapine results in decreased expression of DYNC1LI2 protein