muscarinic antagonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	muscarinic antagonist	go back to main search page
Accession:	CHEBI:48876	browse the term
Definition:	A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
Synonyms:	related_synonym:	Antimuskarinika; Antimuskarinikum; agente antimuscarinico; agentes antimuscarinicos; agents antimuscariniques; antimuscarinic agents; antimuscarinicos; muscarinic acetylcholine receptor antagonist; muscarinic antagonists

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Rat (1592 ) Mouse (1567 ) Human (1582 ) Chinchilla (0 ) Bonobo (0 ) Dog (2 ) Squirrel (0 ) Pig (3 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (1592)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

EXP

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

advanced glycosylation end product-specific receptor

increases expression
multiple interactions

EXP

Tramadol results in increased expression of AGER mRNA
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of AGER mRNA]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

EXP

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

activating transcription factor 4

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of ATF4 mRNA]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

EXP

Tramadol results in increased expression of BAX mRNA; Tramadol results in increased expression of BAX protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of BAX mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of BAX protein]

PMID:25550769 PMID:39848458

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

decreases activity

EXP

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of BCL2 mRNA; Tramadol results in decreased expression of BCL2 protein
Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2L1 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2L1 protein]
Tramadol results in decreased expression of BCL2L1 mRNA; Tramadol results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

affects activity
multiple interactions
increases expression
decreases activity

ISO
EXP

Tramadol affects the activity of CASP3 protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of CASP3 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of CASP3 protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in increased expression of CASP3 mRNA; Tramadol results in increased expression of CASP3 protein
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080 PMID:39848458

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

creatine kinase B

decreases expression
multiple interactions

ISO
EXP

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

ISO

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing

ISO

CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

desmin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

dopamine receptor D2

increases expression

EXP

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

increases expression

EXP

Tramadol results in increased expression of DRD3 protein

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

EXP

Tramadol results in increased expression of EIF2AK3 mRNA
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of EIF2AK3 mRNA]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of EIF2S1 mRNA]

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

gap junction protein, alpha 1

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases expression

EXP

Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

EXP

Tramadol results in increased activity of GPT protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080 PMID:39848458

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

hepatitis A virus cellular receptor 1

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

5-hydroxytryptamine receptor 2A

increases activity
increases expression
multiple interactions

EXP

Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

interferon gamma

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

increases expression
multiple interactions

EXP

Tramadol results in increased expression of IL1B mRNA; Tramadol results in increased expression of IL1B protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

lactate dehydrogenase A

decreases expression

ISO

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

ISO

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of NFKB1 mRNA]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NLR family, pyrin domain containing 3

increases expression
multiple interactions

EXP

Tramadol results in increased expression of NLRP3 mRNA
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of NLRP3 mRNA]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NPHS1 adhesion molecule, nephrin

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of NPHS1 protein
Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of NPHS1 protein]

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521

G

opioid receptor, delta 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

poly (ADP-ribose) polymerase 1

increases expression
multiple interactions

EXP

Tramadol results in increased expression of PARP1 mRNA
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of PARP1 mRNA]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate dehydrogenase kinase 3

increases expression

ISO

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:62,480,535...62,547,371
Ensembl chr X:62,480,535...62,547,371

G

prodynorphin

decreases expression

EXP

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

solute carrier family 2 member 4

multiple interactions

EXP

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 47 member 1

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

superoxide dismutase 1

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

EXP

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

secreted phosphoprotein 1

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

tumor necrosis factor

multiple interactions
increases expression

EXP

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of TNF mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]
Tramadol results in increased expression of TNF mRNA; Tramadol results in increased expression of TNF protein

PMID:17377112 PMID:31618080 PMID:33645892 PMID:39848458

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin I3, cardiac type

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

vimentin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

4-DAMP methiodide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 3

affects binding

IDA

4-DAMP methiodide inhibits response to acetylcholine in rat aortic rings

RGD

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD40 molecule

multiple interactions

ISO

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

cholinergic receptor, muscarinic 1

multiple interactions

ISO

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions

ISO

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]

PMID:9846649 PMID:11306684

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor, muscarinic 5

multiple interactions

ISO

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

citrate synthase

decreases activity

EXP

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

dynamin 1-like

increases phosphorylation

EXP

4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased phosphorylation of DNM1L protein

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

fission, mitochondrial 1

increases expression

EXP

4-diphenylacetoxy-1,1-dimethylpiperidinium results in increased expression of FIS1 protein

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [oxotremorine M results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

mitofusin 1

decreases expression

EXP

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN1 protein

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

mitofusin 2

decreases expression

EXP

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN2 protein

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

OPA1, mitochondrial dynamin like GTPase

decreases expression

EXP

4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of OPA1 protein

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

acetylcholinesterase

multiple interactions

ISO
EXP

Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adenylate cyclase 5

increases response to substance

ISO

ADCY5 protein results in increased susceptibility to Atropine

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

albumin

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in decreased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aquaporin 5

multiple interactions

ISO

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCAR1 scaffold protein, Cas family member

multiple interactions

ISO

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

butyrylcholinesterase

multiple interactions

EXP
ISO

[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX-agent

PMID:17963125 PMID:22981459

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

bradykinin receptor B2

multiple interactions

ISO

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

bone morphogenetic protein 6

multiple interactions

EXP

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

EXP

Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983

G

calcitonin-related polypeptide alpha

affects activity

EXP

Atropine affects the activity of CALCA protein

PMID:7906887 PMID:10075105

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

caspase 3

increases expression
multiple interactions

EXP

Atropine results in increased expression of CASP3 mRNA
Atropine inhibits the reaction [Dichlorvos results in increased expression of CASP3 mRNA]

PMID:19815060 PMID:39733793

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 5

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin A1

increases expression
multiple interactions

ISO

Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin D3

multiple interactions

ISO

[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin E1

increases expression
multiple interactions

ISO

Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin E2

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

CD40 molecule

multiple interactions

ISO

Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

cell division cycle 20

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 6

multiple interactions

ISO

[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:84,360,381...84,374,241

G

cyclin-dependent kinase 1

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

carboxylesterase 1D

multiple interactions

ISO

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

cholinergic receptor, muscarinic 1

multiple interactions
decreases activity

ISO

Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]

PMID:16439611 PMID:18316702 PMID:31830555

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

Atropine binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions
decreases activity

ISO

Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein

PMID:15140916 PMID:20708676 PMID:31830555

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor, muscarinic 4

multiple interactions
affects binding

ISO

[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

cholinergic receptor, muscarinic 5

multiple interactions

ISO

Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

ISO
EXP

Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]

PMID:15733544 PMID:21791372

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

ISO
EXP

Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:15733544 PMID:21791372

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

cAMP responsive element binding protein 1

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

corticotropin releasing hormone

multiple interactions

EXP
ISO

Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein

PMID:12039681 PMID:12906840

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

catenin beta 1

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

dishevelled segment polarity protein 2

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]

NCBI chr10:55,222,245...55,231,506
Ensembl chr10:55,222,056...55,231,506

G

endothelin 1

multiple interactions

ISO

EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

eukaryotic translation elongation factor 2

multiple interactions

ISO

atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells]

RGD

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544

G

epidermal growth factor receptor

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions

EXP

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

multiple interactions

EXP

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

ezrin

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of EZR protein]

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

coagulation factor II, thrombin

multiple interactions

ISO

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

coagulation factor II (thrombin) receptor

multiple interactions

ISO

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

EXP
ISO

Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

ghrelin and obestatin prepropeptide

multiple interactions

EXP

Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

glycine receptor, alpha 1

multiple interactions

ISO

Atropine binds to and results in decreased activity of GLRA1 protein

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:40,130,121...40,227,815

G

glutamic--pyruvic transaminase

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutamate metabotropic receptor 4

multiple interactions

ISO

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,482,977...5,574,668

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in decreased activity of HMGCR protein]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

intercellular adhesion molecule 1

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 10

multiple interactions

EXP

Atropine inhibits the reaction [Dichlorvos results in decreased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

ISO

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of KIT protein]

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

lactotransferrin

multiple interactions

ISO

Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189

G

mitogen activated protein kinase 1

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

minichromosome maintenance complex component 4

multiple interactions
increases expression

ISO

[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:98,762,634...98,776,536

G

minichromosome maintenance complex component 6

increases expression
multiple interactions

ISO

Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467

G

neurofilament heavy chain

affects expression

EXP

Atropine affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

NLR family, pyrin domain containing 3

increases expression

ISO

Atropine results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions

EXP

Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]

PMID:15610444 PMID:16944022

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

notch receptor 4

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072

G

natriuretic peptide A

affects activity

EXP

Atropine affects the activity of NPPA protein modified form

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

opioid related nociceptin receptor 1

multiple interactions

EXP

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426

G

proliferating cell nuclear antigen

multiple interactions

ISO

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

prepronociceptin

multiple interactions

EXP

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr15:43,800,240...43,827,841
Ensembl chr15:43,800,246...43,827,470

G

proopiomelanocortin

multiple interactions

EXP

Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]

PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

multiple interactions

ISO

Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

paxillin

multiple interactions

ISO

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]

NCBI chr12:46,721,546...46,768,706
Ensembl chr12:46,721,546...46,768,697

G

Rac family small GTPase 3

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]

NCBI chr10:106,501,133...106,503,569
Ensembl chr10:106,501,135...106,503,569

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]; Atropine inhibits the reaction [Dichlorvos results in increased expression of RELA mRNA]

PMID:21971501 PMID:39733793

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ras homolog family member A

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein]

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

solute carrier family 22 member 1

multiple interactions

ISO

Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16263091 PMID:21641380

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

PMID:16263091 PMID:21599003 PMID:23770354

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

increases uptake
multiple interactions

ISO

SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 4

multiple interactions

ISO

Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,634,098...38,679,920

G

solute carrier family 47 member 1

multiple interactions

ISO

Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Atropine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

suppressor of cytokine signaling 3

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

sialophorin

increases response to substance

ISO

SPN protein results in increased susceptibility to Atropine

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852

G

tyrosine aminotransferase

multiple interactions

EXP

[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

transforming growth factor, beta 1

multiple interactions

EXP

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

ISO

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

trio Rho guanine nucleotide exchange factor

multiple interactions

ISO

Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]

NCBI chr 2:80,235,485...80,531,824
Ensembl chr 2:80,235,485...80,531,612

G

transient receptor potential cation channel, subfamily A, member 1

decreases response to substance

ISO

TRPA1 gene mutant form results in decreased susceptibility to Atropine

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325

G

thyroid stimulating hormone subunit beta

multiple interactions

EXP

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

translocator protein

multiple interactions

EXP

[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460

G

vascular cell adhesion molecule 1

multiple interactions

ISO

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Benztropine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

acyl-CoA thioesterase 2

increases expression

ISO

Benztropine results in increased expression of ACOT2 protein

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

actin, beta-like 2

increases expression

ISO

Benztropine results in increased expression of ACTBL2 protein

NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:44,591,391...44,594,138

G

actin related protein 1A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of ACTR1A protein

NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:255,179,242...255,199,459

G

actin related protein 3

decreases expression

ISO

Benztropine results in decreased expression of ACTR3 protein

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

adenylosuccinate lyase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of ADSL protein

NCBI chr 7:114,359,440...114,383,618
Ensembl chr 7:114,359,440...114,384,872

G

alkylglycerone phosphate synthase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of AGPS protein

NCBI chr 3:81,154,599...81,253,099
Ensembl chr 3:81,154,604...81,258,277

G

adenylate kinase 1

decreases expression

ISO

Benztropine results in decreased expression of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

annexin A1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A5

decreases expression

ISO

Benztropine results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

annexin A6

decreases expression

ISO

Benztropine results in decreased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359

G

annexin A7

increases expression

ISO

Benztropine results in increased expression of ANXA7 protein

NCBI chr15:3,869,180...3,897,827
Ensembl chr15:3,870,974...3,898,891

G

acidic residue methyltransferase 1

increases expression

ISO

Benztropine results in increased expression of DCPH1 protein

NCBI chr 1:43,299,916...43,323,675
Ensembl chr 1:43,299,826...43,323,670

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

ISO

Benztropine results in decreased expression of ASNS protein

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartate-beta-hydroxylase

increases expression

ISO

Benztropine results in increased expression of ASPH protein

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:27,398,949...27,611,215

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

ISO

Benztropine results in increased expression of ATP2A3 protein

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:58,079,852...58,111,278

G

ATP synthase F1 subunit gamma

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of ATP5F1C protein

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATPase H+ transporting V1 subunit B2

decreases expression

ISO

Benztropine results in decreased expression of ATP6V1B2 protein

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ataxin 10

increases expression

ISO

Benztropine results in increased expression of ATXN10 protein

NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:118,319,490...118,445,636

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of BAZ1B protein

NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511

G

BCAR1 scaffold protein, Cas family member

decreases expression

ISO

Benztropine results in decreased expression of BCAR1 protein

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

bridge-like lipid transfer protein family member 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of BLTP1 protein

NCBI chr 2:121,636,181...121,852,802
Ensembl chr 2:121,636,323...121,852,802

G

bone morphogenetic protein 6

increases expression

ISO

Benztropine results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

bromodomain containing 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of BRD2 protein

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290

G

basigin

decreases expression

ISO

Benztropine results in decreased expression of BSG protein

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005

G

caldesmon 1

decreases expression
multiple interactions

ISO

Benztropine results in decreased expression of CALD1 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of CALD1 protein

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

calumenin

decreases expression

ISO

Benztropine results in decreased expression of CALU protein

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of CAMK2D protein

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

cell cycle associated protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CAPRIN1 protein

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

caspase 8 associated protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CASP8AP2 protein

NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632

G

chromobox 5

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of CBX5 protein

NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:136,211,649...136,229,118

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

Benztropine results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 121

increases expression

ISO

Benztropine results in increased expression of CCDC121 protein

NCBI chr 6:30,690,831...30,693,437
Ensembl chr 6:30,690,831...30,693,437

G

chaperonin containing TCP1 subunit 6A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein

NCBI chr12:32,508,842...32,519,072
Ensembl chr12:32,508,675...32,519,119

G

chaperonin containing TCP1 subunit 7

decreases expression

ISO

Benztropine results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

chaperonin containing TCP1 subunit 8

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein

NCBI chr11:40,196,619...40,208,328
Ensembl chr11:40,196,619...40,208,328

G

Cd276 molecule

decreases expression

ISO

Benztropine results in decreased expression of CD276 protein

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

centromere protein V

increases expression

ISO

Benztropine results in increased expression of CENPV protein

NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,713,778...47,727,679

G

chromodomain helicase DNA binding protein 4

decreases expression

ISO

Benztropine results in decreased expression of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

creatine kinase B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of CKB protein

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

2',3'-cyclic nucleotide 3' phosphodiesterase

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CNP protein
Benztropine results in decreased expression of CNP protein

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

collagen type XIV alpha 1 chain

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of COL14A1 protein

NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:88,611,828...88,826,938

G

collagen type V alpha 2 chain

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of COL5A2 protein

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

COP9 signalosome subunit 4

decreases expression

ISO

Benztropine results in decreased expression of COPS4 protein

NCBI chr14:9,382,897...9,413,216
Ensembl chr14:9,382,900...9,413,107

G

coronin 1B

decreases expression

ISO

Benztropine results in decreased expression of CORO1B protein

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:210,871,841...210,877,876

G

coronin 7

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CORO7 protein

NCBI chr10:11,386,683...11,447,422
Ensembl chr10:11,391,613...11,447,866

G

copine 3

decreases expression

ISO

Benztropine results in decreased expression of CPNE3 protein

NCBI chr 5:37,811,566...37,860,840
Ensembl chr 5:37,811,566...37,861,062

G

cleavage and polyadenylation specific factor 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CPSF3 protein

NCBI chr 6:46,564,855...46,592,776
Ensembl chr 6:46,564,735...46,594,136

G

cartilage associated protein

increases expression

ISO

Benztropine results in increased expression of CRTAP protein

NCBI chr 8:122,926,117...122,945,843
Ensembl chr 8:122,926,117...122,945,843

G

crystallin zeta

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CRYZ protein

NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:246,211,156...246,239,470

G

cold shock domain containing E1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CSDE1 protein

NCBI chr 2:193,234,546...193,271,301
Ensembl chr 2:193,243,526...193,271,301

G

cleavage stimulation factor subunit 2

decreases expression

ISO

Benztropine results in decreased expression of CSTF2 protein

NCBI chr X:101,546,809...101,572,760
Ensembl chr X:101,546,819...101,572,764

G

C-terminal binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CTBP1 protein

NCBI chr14:81,679,956...81,707,331
Ensembl chr14:81,679,765...81,707,554

G

cullin 2

increases expression

ISO

Benztropine results in increased expression of CUL2 protein

NCBI chr17:58,864,274...58,905,447
Ensembl chr17:58,864,274...58,905,132

G

cullin 4B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of CUL4B protein

NCBI chr X:122,154,332...122,192,299
Ensembl chr X:122,154,332...122,192,299

G

aspartyl-tRNA synthetase 2 (mitochondrial)

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of DARS2 protein

NCBI chr13:75,842,078...75,870,319
Ensembl chr13:75,836,565...75,869,904

G

DAZ associated protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of DAZAP1 protein

NCBI chr 7:10,074,342...10,098,810
Ensembl chr 7:10,074,849...10,095,599

G

dynactin subunit 2

increases expression

ISO

Benztropine results in increased expression of DCTN2 protein

NCBI chr 7:64,977,338...64,992,875
Ensembl chr 7:64,977,363...64,992,873

G

DEAD-box helicase 17

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX17 protein

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747

G

DEAD-box helicase 3, X-linked

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DDX3X protein

NCBI chr X:12,152,346...12,165,983
Ensembl chr X:12,152,346...12,165,983

G

DiGeorge syndrome critical region gene 6

decreases expression

ISO

Benztropine results in decreased expression of DGCR6 protein

NCBI chr11:96,432,024...96,442,766
Ensembl chr11:96,432,024...96,437,255

G

24-dehydrocholesterol reductase

increases expression

ISO

Benztropine results in increased expression of DHCR24 protein

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

DEAH-box helicase 8

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DHX8 protein

NCBI chr10:87,167,861...87,204,426
Ensembl chr10:87,168,062...87,205,875

G

dihydrolipoamide S-acetyltransferase

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DLAT protein
Benztropine results in increased expression of DLAT protein

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

discs large MAGUK scaffold protein 2

increases expression

ISO

Benztropine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

ISO

Benztropine results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

dipeptidylpeptidase 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of DPP3 protein

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:211,634,068...211,658,310

G

dihydropyrimidinase-like 2

decreases expression

ISO

Benztropine results in decreased expression of DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065

G

dihydropyrimidinase-like 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of DPYSL3 protein

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

ISO

Benztropine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167

G

EBNA1 binding protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EBNA1BP2 protein

NCBI chr 5:137,433,534...137,438,100
Ensembl chr 5:137,433,226...137,438,637

G

eukaryotic translation elongation factor 1 gamma

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EEF1G protein

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

ISO

Benztropine results in increased expression of EIF2S3 protein

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:62,910,293...62,934,489

G

eukaryotic translation initiation factor 3, subunit B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3B protein

NCBI chr12:19,310,308...19,334,768
Ensembl chr12:19,310,311...19,334,939

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3C protein

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 3, subunit H

decreases expression

ISO

Benztropine results in decreased expression of EIF3H protein

NCBI chr 7:84,980,891...85,064,284
Ensembl chr 7:84,980,891...85,071,546

G

eukaryotic translation initiation factor 3, subunit L

increases expression
multiple interactions

ISO

Benztropine results in increased expression of EIF3L protein
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3L protein

NCBI chr 7:112,522,222...112,544,063
Ensembl chr 7:112,507,831...112,544,062

G

eukaryotic translation initiation factor 5

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5 protein

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

eukaryotic translation initiation factor 5B

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein
Benztropine results in increased expression of EIF5B protein

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583

G

eukaryotic translation initiation factor 6

decreases expression

ISO

Benztropine results in decreased expression of EIF6 protein

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

enolase 1

decreases expression

ISO

Benztropine results in decreased expression of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

Eph receptor B3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775

G

Epsin 1

decreases expression

ISO

Benztropine results in decreased expression of EPN1 protein

NCBI chr 1:77,771,335...77,789,411
Ensembl chr 1:77,771,335...77,789,411

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

ISO

Benztropine results in decreased expression of EPS8 protein

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:172,119,497...172,218,160

G

ERH, mRNA splicing and mitosis factor

increases expression

ISO

Benztropine results in increased expression of ERH protein

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623

G

ER lipid raft associated 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of ERLIN2 protein

NCBI chr16:71,720,486...71,736,999
Ensembl chr16:71,721,364...71,736,503

G

EWS RNA-binding protein 1

decreases expression

ISO

Benztropine results in decreased expression of EWSR1 protein

NCBI chr14:84,179,413...84,208,149
Ensembl chr14:84,179,618...84,208,095

G

exosome component 9

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of EXOSC9 protein

NCBI chr 2:121,344,154...121,355,110
Ensembl chr 2:121,344,175...121,374,232

G

ezrin

decreases expression

ISO

Benztropine results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

fatty acid binding protein 3

increases expression

ISO

Benztropine results in increased expression of FABP3 protein

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

farnesyl diphosphate synthase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of FDPS protein

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

flotillin 2

increases expression

ISO

Benztropine results in increased expression of FLOT2 protein

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:63,423,806...63,445,810

G

Fms related receptor tyrosine kinase 1

decreases expression

ISO

Benztropine results in decreased expression of FLT1 protein

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

FYVE and coiled-coil domain autophagy adaptor 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of FYCO1 protein

NCBI chr 8:132,289,538...132,356,810
Ensembl chr 8:132,289,539...132,356,451

G

G3BP stress granule assembly factor 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of G3BP2 protein

NCBI chr14:16,216,684...16,304,828
Ensembl chr14:16,248,744...16,304,823

G

glucose-6-phosphate dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

polypeptide N-acetylgalactosaminyltransferase 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GALNT2 protein

NCBI chr19:69,110,657...69,222,237
Ensembl chr19:69,110,657...69,222,237

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

GATA zinc finger domain containing 2B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GATAD2B protein

NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:178,046,085...178,147,315

G

guanine deaminase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GDA protein

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

glutamine fructose-6-phosphate transaminase 1

decreases expression

ISO

Benztropine results in decreased expression of GFPT1 protein

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799

G

gamma-glutamyl cyclotransferase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GGCT protein

NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:85,453,387...85,470,224

G

glutaredoxin 3

increases expression

ISO

Benztropine results in increased expression of GLRX3 protein

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glutaminase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GLS protein

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861

G

G protein subunit alpha 12

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GNA12 protein

NCBI chr12:18,919,629...19,000,185
Ensembl chr12:18,919,629...19,000,185

G

golgin A4

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GOLGA4 protein

NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603

G

golgin B1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GOLGB1 protein

NCBI chr11:77,348,573...77,406,165
Ensembl chr11:77,348,961...77,406,006

G

glutamic-oxaloacetic transaminase 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of GOT2 protein

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111

G

glucose-6-phosphate isomerase

increases expression

ISO

Benztropine results in increased expression of GPI protein

NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261

G

G patch domain and KOW motifs

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GPKOW protein

NCBI chr X:17,463,521...17,478,298
Ensembl chr X:17,463,525...17,478,298

G

general transcription factor IIE subunit 1

decreases expression

ISO

Benztropine results in decreased expression of GTF2E1 protein

NCBI chr11:76,687,382...76,720,253
Ensembl chr11:76,687,772...76,720,784

G

general transcription factor IIF subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GTF2F1 protein

NCBI chr 9:1,931,033...1,940,197
Ensembl chr 9:1,930,055...1,940,197

G

GTP binding protein 4

increases expression

ISO

Benztropine results in increased expression of GTPBP4 protein

NCBI chr17:65,997,472...66,019,530
Ensembl chr17:66,276,566...66,289,637

G

glycogen synthase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein

NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:105,051,961...105,072,419

G

H2A clustered histone 20

increases expression

ISO

Benztropine results in increased expression of H2AC20 protein

NCBI chr 2:186,468,748...186,469,226

G

H2A.J histone

increases expression

ISO

Benztropine results in increased expression of H2AJ protein

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

ISO

Benztropine results in increased expression of HACD3 protein

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

ISO

Benztropine results in increased expression of HADHB protein

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

histidyl-tRNA synthetase 1

increases expression

ISO

Benztropine results in increased expression of HARS1 protein

NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,655,671...28,672,712

G

histone acetyltransferase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of HAT1 protein

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

host cell factor C1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HCFC1 protein

NCBI chr X:156,839,100...156,864,132
Ensembl chr X:156,839,100...156,863,813

G

hemicentin 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HMCN2 protein

NCBI chr 3:34,986,246...35,136,047
Ensembl chr 3:34,986,263...35,136,106

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

ISO

Benztropine results in decreased expression of HNRNPD protein

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of HNRNPK protein

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HPS3 protein

NCBI chr 2:104,413,618...104,455,091
Ensembl chr 2:104,413,417...104,455,091

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

ISO

Benztropine results in increased expression of HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

heat shock protein 90 beta family member 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of HSP90B1 protein

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Benztropine results in decreased expression of IDI1 protein

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

interleukin 1 alpha

decreases expression

ISO

Benztropine results in decreased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

decreases expression

ISO

Benztropine results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

Benztropine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

junctional adhesion molecule 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

Jupiter microtubule associated homolog 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of JPT2 protein

NCBI chr10:14,467,652...14,487,769
Ensembl chr10:14,467,661...14,535,664

G

lysyl-tRNA synthetase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of KARS1 protein

NCBI chr19:56,867,096...56,886,151
Ensembl chr19:56,867,096...56,886,073

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Benztropine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium channel tetramerization domain containing 12

decreases expression

ISO

Benztropine results in decreased expression of KCTD12 protein

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

ISO

Benztropine results in decreased expression of KHDRBS1 protein

NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448

G

kinesin family member 5C

decreases expression

ISO

Benztropine results in decreased expression of KIF5C protein

NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813

G

kelch domain containing 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of KLHDC2 protein

NCBI chr 6:93,512,981...93,552,809
Ensembl chr 6:93,513,017...93,577,762

G

kelch-like family member 41

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of KLHL41 protein

NCBI chr 3:74,842,118...74,855,244

G

karyopherin subunit alpha 4

increases expression

ISO

Benztropine results in increased expression of KPNA4 protein

NCBI chr 2:155,635,679...155,691,056
Ensembl chr 2:155,634,247...155,691,053

G

kinectin 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of KTN1 protein
Benztropine results in decreased expression of KTN1 protein

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:23,394,315...23,482,263

G

lactamase, beta 2

increases expression

ISO

Benztropine results in increased expression of LACTB2 protein

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:10,352,154...10,379,255

G

laminin subunit beta 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of LAMB1 protein

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760

G

laminin subunit gamma 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of LAMC1 protein

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986

G

LIM domain and actin binding 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of LIMA1 protein

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:132,780,556...132,880,386

G

lipase A, lysosomal acid type

increases expression

ISO

Benztropine results in increased expression of LIPA protein

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740

G

leiomodin 2

increases expression

ISO

Benztropine results in increased expression of LMOD2 protein

NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:54,032,974...54,040,666

G

lanosterol synthase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of LSS protein

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

leukotriene A4 hydrolase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of LTA4H protein

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641

G

LUC7 pre-mRNA splicing factor like 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of LUC7L protein

NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,777,829...15,817,940

G

MAGE family member A9

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9 protein

NCBI chr X:147,655,721...147,661,093
Ensembl chr X:147,655,721...147,661,093

G

MAGE family member D2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MAGED2 protein

NCBI chr X:23,160,928...23,364,994
Ensembl chr X:23,160,931...23,169,104

G

microtubule-associated protein 1S

increases expression

ISO

Benztropine results in increased expression of MAP1S protein

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,551,573...18,562,141

G

microtubule-associated protein 4

decreases expression

ISO

Benztropine results in decreased expression of MAP4 protein

NCBI chr 8:118,800,393...118,942,805
Ensembl chr 8:118,804,022...118,942,805

G

microtubule-associated protein, RP/EB family, member 1

decreases expression

ISO

Benztropine results in decreased expression of MAPRE1 protein

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:162,673,195...162,711,210

G

MARCKS-like 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:147,134,514...147,138,417

G

methionine adenosyltransferase 2 non-catalytic beta subunit

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of MAT2B protein

NCBI chr10:25,609,202...25,626,694
Ensembl chr10:25,609,204...25,625,176

G

membrane bound O-acyltransferase domain containing 7

decreases expression

ISO

Benztropine results in decreased expression of MBOAT7 protein

NCBI chr 1:74,440,618...74,454,896
Ensembl chr 1:74,439,660...74,454,894

G

malate dehydrogenase 1

decreases expression

ISO

Benztropine results in decreased expression of MDH1 protein

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Benztropine results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

methionyl aminopeptidase 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of METAP2 protein

NCBI chr 7:30,299,433...30,327,477
Ensembl chr 7:30,299,433...30,327,521

G

macrophage migration inhibitory factor

increases expression

ISO

Benztropine results in increased expression of MIF protein

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

metadherin

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of MTDH protein

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of MTHFD1L protein

NCBI chr 1:42,849,424...43,038,313
Ensembl chr 1:42,849,374...43,038,309

G

myosin heavy chain 3

increases expression

ISO

Benztropine results in increased expression of MYH3 protein

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000

G

N-acetyltransferase 10

decreases expression

ISO

Benztropine results in decreased expression of NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:110,566,582...110,604,836

G

nuclear cap binding protein subunit 1

decreases expression

ISO

Benztropine results in decreased expression of NCBP1 protein

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

nectin cell adhesion molecule 2

decreases expression

ISO

Benztropine results in decreased expression of NECTIN2 protein

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305

G

nicotinamide N-methyltransferase

increases expression

ISO

Benztropine results in increased expression of NNMT protein

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

ISO

Benztropine results in increased expression of NOC2L protein

NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:172,101,223...172,114,162

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

ISO

Benztropine results in decreased expression of NSF protein

NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621

G

NSFL1 cofactor

decreases expression

ISO

Benztropine results in decreased expression of NSFL1C protein

NCBI chr 3:160,438,708...160,463,261
Ensembl chr 3:160,438,708...160,463,228

G

nuclear mitotic apparatus protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of NUMA1 protein

NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848

G

nucleoporin 153

increases expression

ISO

Benztropine results in increased expression of NUP153 protein

NCBI chr17:18,178,434...18,231,109
Ensembl chr17:18,178,456...18,231,109

G

nucleoporin 50

increases expression

ISO

Benztropine results in increased expression of NUP50 protein

NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:117,925,716...117,946,959

G

nucleoporin 54

decreases expression

ISO

Benztropine results in decreased expression of NUP54 protein

NCBI chr14:15,901,936...15,920,335
Ensembl chr14:15,901,991...15,920,334

G

nucleoporin 93

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of NUP93 protein

NCBI chr19:10,690,154...10,793,937
Ensembl chr19:10,687,115...10,793,380

G

nuclear RNA export factor 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of NXF1 protein

NCBI chr 1:215,084,563...215,097,756
Ensembl chr 1:215,084,099...215,097,756

G

ornithine aminotransferase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of OAT protein

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

oxoglutarate dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of OGDH protein

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

Obg-like ATPase 1

increases expression

ISO

Benztropine results in increased expression of OLA1 protein

NCBI chr 3:78,374,440...78,493,401
Ensembl chr 3:78,374,441...78,492,012

G

prolyl 4-hydroxylase subunit beta

decreases expression

ISO

Benztropine results in decreased expression of P4HB protein

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

proliferation-associated 2G4

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PA2G4 protein

NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:1,569,327...1,576,802

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 protein

NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

decreases expression

ISO

Benztropine results in decreased expression of PAG1 protein

NCBI chr 2:93,842,747...93,984,314
Ensembl chr 2:93,964,594...93,977,227

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein
Benztropine results in decreased expression of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate carboxylase

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

poly(rC) binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PCBP1 protein

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111

G

poly(rC) binding protein 2

decreases expression

ISO

Benztropine results in decreased expression of PCBP2 protein

NCBI chr 7:135,483,702...135,508,254
Ensembl chr 7:135,483,856...135,509,412

G

protocadherin gamma subfamily A, 2

decreases expression

ISO

Benztropine results in decreased expression of PCDHGA2 protein

NCBI chr18:29,745,189...29,919,095

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

decreases expression

ISO

Benztropine results in decreased expression of PCMT1 protein

NCBI chr 1:3,932,161...3,980,751
Ensembl chr 1:3,932,161...3,964,848

G

PEST proteolytic signal containing nuclear protein

increases expression

ISO

Benztropine results in increased expression of PCNP protein

NCBI chr11:58,061,885...58,076,436
Ensembl chr11:58,061,570...58,076,436

G

phosducin-like 3

decreases expression

ISO

Benztropine results in decreased expression of PDCL3 protein

NCBI chr 9:48,730,083...48,738,554
Ensembl chr 9:48,723,767...48,739,529

G

protein disulfide isomerase family A, member 3

decreases expression

ISO

Benztropine results in decreased expression of PDIA3 protein

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 6

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PDIA6 protein

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

PDZ and LIM domain 5

decreases expression

ISO

Benztropine results in decreased expression of PDLIM5 protein

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

phosphatidylethanolamine binding protein 1

decreases expression

ISO

Benztropine results in decreased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

profilin 1

increases expression

ISO

Benztropine results in increased expression of PFN1 protein

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

phosphoglycerate kinase 1

decreases expression

ISO

Benztropine results in decreased expression of PGK1 protein

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

phosphoglucomutase 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PGM3 protein

NCBI chr 8:96,398,331...96,416,045
Ensembl chr 8:96,398,269...96,416,021

G

PHD finger protein 14

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PHF14 protein

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043

G

phosphoglycerate dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of PHGDH protein

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Benztropine results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PIN1 protein

NCBI chr 8:27,465,538...27,477,016

G

peptidase, mitochondrial processing subunit alpha

increases expression

ISO

Benztropine results in increased expression of PMPCA protein

NCBI chr 3:29,605,823...29,614,936
Ensembl chr 3:29,604,232...29,614,935

G

PNMA family member 1

increases expression

ISO

Benztropine results in increased expression of PNMA1 protein

NCBI chr 6:109,513,382...109,515,167
Ensembl chr 6:109,507,773...109,515,451

G

PNMA family member 8A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PNMA8A protein

NCBI chr 1:86,763,475...86,771,117
Ensembl chr 1:86,756,168...86,815,182

G

paraoxonase 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PON3 protein

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

inorganic pyrophosphatase 1

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PPA1 protein
Benztropine results in increased expression of PPA1 protein

NCBI chr20:30,132,088...30,160,492
Ensembl chr20:30,133,504...30,160,489

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

decreases expression

ISO

Benztropine results in decreased expression of PPM1F protein

NCBI chr11:97,568,627...97,598,613
Ensembl chr11:97,568,625...97,598,545

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PPP1R12A protein

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PPP1R14B protein

NCBI chr 1:213,594,416...213,596,527
Ensembl chr12:21,088,517...21,101,431
Ensembl chr 1:21,088,517...21,101,431

G

protein phosphatase 3 catalytic subunit alpha

increases expression

ISO

Benztropine results in increased expression of PPP3CA protein

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PRKAR2A protein

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330

G

PRKCSH beta subunit of glucosidase II

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of PRKCSH protein

NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:28,810,889...28,822,503

G

protein arginine methyltransferase 1

decreases expression

ISO

Benztropine results in decreased expression of PRMT1 protein

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827

G

pre-mRNA processing factor 6

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of PRPF6 protein

NCBI chr 3:189,084,465...189,148,705
Ensembl chr 3:189,081,794...189,152,786

G

proteasome 20S subunit alpha 1

decreases expression

ISO

Benztropine results in decreased expression of PSMA1 protein

NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:177,875,353...177,887,949

G

proteasome 20S subunit beta 7

decreases expression

ISO

Benztropine results in decreased expression of PSMB7 protein

NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:42,767,501...42,827,601

G

proteasome 26S subunit, ATPase 1

decreases expression

ISO

Benztropine results in decreased expression of PSMC1 protein

NCBI chr 6:125,122,497...125,134,859
Ensembl chr 6:125,122,490...125,134,858

G

proteasome 26S subunit, ATPase 3

increases expression

ISO

Benztropine results in increased expression of PSMC3 protein

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, non-ATPase 7

increases expression

ISO

Benztropine results in increased expression of PSMD7 protein

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871

G

Pentatricopeptide repeat domain 3

increases expression
multiple interactions

ISO

Benztropine results in increased expression of PTCD3 protein
[Cuprizone co-treated with Benztropine] results in decreased expression of PTCD3 protein

NCBI chr 4:105,480,699...105,508,007
Ensembl chr 4:105,480,709...105,513,276

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Benztropine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 7

decreases expression

ISO

Benztropine results in decreased expression of PTK7 protein

NCBI chr 9:21,849,756...21,916,077
Ensembl chr 9:21,849,801...21,916,078

G

poly-U binding splicing factor 60

decreases expression

ISO

Benztropine results in decreased expression of PUF60 protein

NCBI chr 7:109,663,490...109,674,443
Ensembl chr 7:109,663,490...109,674,724

G

PWP2, small subunit processome component

increases expression

ISO

Benztropine results in increased expression of PWP2 protein

NCBI chr20:10,498,998...10,512,631
Ensembl chr20:10,499,013...10,513,309

G

pyrroline-5-carboxylate reductase 1

increases expression

ISO

Benztropine results in increased expression of PYCR1 protein

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

quinoid dihydropteridine reductase

decreases expression

ISO

Benztropine results in decreased expression of QDPR protein

NCBI chr14:69,882,776...69,896,378
Ensembl chr14:69,882,612...69,896,379

G

receptor for activated C kinase 1

decreases expression

ISO

Benztropine results in decreased expression of RACK1 protein

NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948

G

RNA binding motif protein 15

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of RBM15 protein

NCBI chr 2:197,634,174...197,642,697
Ensembl chr 2:197,583,002...197,643,037

G

RIC8 guanine nucleotide exchange factor A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of RIC8A protein

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102

G

ribosomal protein L10A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL10A protein

NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,390,179...6,393,091

G

ribosomal protein L19

increases expression

ISO

Benztropine results in increased expression of RPL19 protein

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352

G

ribosomal protein L24

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPL24 protein

NCBI chr11:58,122,997...58,128,405
Ensembl chr11:58,122,997...58,128,405

G

ribosomal protein L30

increases expression

ISO

Benztropine results in increased expression of RPL30 protein

NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:67,465,332...67,536,555

G

ribosomal protein L7A

decreases expression

ISO

Benztropine results in decreased expression of RPL7A protein

NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791

G

ribosomal protein lateral stalk subunit P1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPLP1 protein

NCBI chr 8:71,289,539...71,290,872
Ensembl chr 8:71,289,535...71,290,872

G

ribosomal protein S12

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS12 protein

NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:23,500,073...23,502,235

G

ribosomal protein S18

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of RPS18 protein

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein S27

increases expression

ISO

Benztropine results in increased expression of RPS27 protein

NCBI chr 2:177,963,499...177,964,708
Ensembl chr 2:177,963,496...177,964,607
Ensembl chr12:177,963,496...177,964,607

G

ribosomal protein S27a

increases expression

ISO

Benztropine results in increased expression of RPS27A protein

NCBI chr14:107,486,664...107,488,941
Ensembl chr 5:138,465,088...138,466,080
Ensembl chr14:138,465,088...138,466,080
Ensembl chr 5:138,465,088...138,466,080

G

ribosomal protein S3

decreases expression

ISO

Benztropine results in decreased expression of RPS3 protein

NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:163,189,842...163,195,776

G

RuvB-like AAA ATPase 2

increases expression

ISO

Benztropine results in increased expression of RUVBL2 protein

NCBI chr 1:105,038,487...105,051,851
Ensembl chr 1:105,038,174...105,051,720

G

SUMO1 activating enzyme subunit 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SAE1 protein

NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:86,159,114...86,215,089

G

seryl-tRNA synthetase 1

decreases expression

ISO

Benztropine results in decreased expression of SARS1 protein

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365

G

SATB homeobox 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SATB2 protein

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:65,844,570...66,021,238

G

saccharopine dehydrogenase (putative)

decreases expression

ISO

Benztropine results in decreased expression of SCCPDH protein

NCBI chr13:93,932,086...93,953,840
Ensembl chr13:93,912,395...93,954,192

G

syndecan binding protein

decreases expression

ISO

Benztropine results in decreased expression of SDCBP protein

NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:24,245,033...24,326,197

G

Sec23 homolog A, COPII coat complex component

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SEC23A protein

NCBI chr 6:82,393,699...82,442,594
Ensembl chr 6:82,394,863...82,440,904

G

SEC61 translocon subunit beta

increases expression

ISO

Benztropine results in increased expression of SEC61B protein

NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028

G

SEC63 homolog, protein translocation regulator

increases expression

ISO

Benztropine results in increased expression of SEC63 protein

NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248

G

Serpine1 mRNA binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SERBP1 protein

NCBI chr 4:97,731,200...97,748,438
Ensembl chr 4:97,731,277...97,751,518

G

serpin family B member 3A

increases expression

ISO

Benztropine results in increased expression of SERPINB4 protein

NCBI chr13:23,755,690...23,766,188
Ensembl chr13:23,756,118...23,766,341

G

splicing factor 1

decreases expression

ISO

Benztropine results in decreased expression of SF1 protein

NCBI chr 1:213,090,256...213,112,688
Ensembl chr 1:213,099,260...213,113,590

G

splicing factor 3b, subunit 3

decreases expression

ISO

Benztropine results in decreased expression of SF3B3 protein

NCBI chr19:55,692,124...55,729,640
Ensembl chr19:55,692,126...55,729,621

G

sarcoglycan, alpha

decreases expression

ISO

Benztropine results in decreased expression of SGCA protein

NCBI chr10:80,397,158...80,416,165
Ensembl chr10:80,405,566...80,419,616

G

SH3 and PX domains 2B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SH3PXD2B protein

NCBI chr10:17,422,906...17,538,977
Ensembl chr10:17,422,947...17,512,854

G

serine hydroxymethyltransferase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SHMT1 protein

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,960,434...45,997,326

G

solute carrier family 22 member 2

multiple interactions

ISO

Benztropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 25 member 5, pseudogene 11

increases expression

ISO

Benztropine results in increased expression of SLC25A6 protein

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597

G

solute carrier family 2 member 1

decreases expression

ISO

Benztropine results in decreased expression of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 38, member 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SLC38A2 protein

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 3 member 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of SLC3A2 protein

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 3

multiple interactions

ISO

Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Benztropine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

ISO

Benztropine results in decreased expression of SMARCB1 protein

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055

G

structural maintenance of chromosomes 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SMC3 protein

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825

G

SMU1, DNA replication regulator and spliceosomal factor

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SMU1 protein

NCBI chr 5:60,652,680...60,671,251
Ensembl chr 5:60,652,680...60,671,251

G

small nuclear ribonucleoprotein U5 subunit 200

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SNRNP200 protein
Benztropine results in increased expression of SNRNP200 protein

NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500

G

small nuclear ribonucleoprotein polypeptide A

increases expression

ISO

Benztropine results in increased expression of SNRPA protein

NCBI chr 1:91,609,419...91,618,119
Ensembl chr 1:91,609,420...91,618,042

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

ISO

Benztropine results in increased expression of SNRPD2 protein

NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:87,926,048...87,933,339
Ensembl chr20:87,926,048...87,933,339

G

splicing regulatory glutamic acid and lysine rich protein 1

decreases expression

ISO

Benztropine results in decreased expression of SREK1 protein

NCBI chr 2:36,583,412...36,618,978
Ensembl chr 2:36,583,412...36,619,001

G

serine and arginine rich splicing factor 5

increases expression

ISO

Benztropine results in increased expression of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

signal transducer and activator of transcription 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stromal interaction molecule 1

decreases expression

ISO

Benztropine results in decreased expression of STIM1 protein

NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:166,067,962...166,233,108

G

stress-induced phosphoprotein 1

decreases expression

ISO

Benztropine results in decreased expression of STIP1 protein

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

serine/threonine kinase receptor associated protein

decreases expression

ISO

Benztropine results in decreased expression of STRAP protein

NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:172,377,305...172,392,436

G

STIP1 homology and U-box containing protein 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of STUB1 protein

NCBI chr10:15,355,278...15,357,559
Ensembl chr10:15,355,279...15,357,559

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

ISO

Benztropine results in decreased expression of SUCLG1 protein

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

small ubiquitin-like modifier 2

decreases expression

ISO

Benztropine results in decreased expression of SUMO2 protein

NCBI chr10:101,270,899...101,283,458
Ensembl chr10:101,270,900...101,283,938
Ensembl chr 5:101,270,900...101,283,938

G

Sad1 and UNC84 domain containing 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of SUN1 protein

NCBI chr12:20,510,230...20,555,123
Ensembl chr12:20,490,861...20,555,240

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

ISO

Benztropine results in decreased expression of SYNCRIP protein

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

transgelin 2

decreases expression

ISO

Benztropine results in decreased expression of TAGLN2 protein

NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330

G

tubulin folding cofactor B

decreases expression

ISO

Benztropine results in decreased expression of TBCB protein

NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:94,605,101...94,610,949

G

TRPM8 channel-associated factor 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TCAF1 protein
Benztropine results in decreased expression of TCAF1 protein

NCBI chr 4:72,589,710...72,639,304
Ensembl chr 4:72,589,710...72,639,475

G

trans-golgi network protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TGOLN2 protein

NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:106,221,509...106,229,262

G

talin 2

decreases expression

ISO

Benztropine results in decreased expression of TLN2 protein

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361

G

thymopoietin

decreases expression

ISO

Benztropine results in decreased expression of TMPO protein

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

tankyrase 1 binding protein 1

multiple interactions
decreases expression

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TNKS1BP1 protein
Benztropine results in decreased expression of TNKS1BP1 protein

NCBI chr 3:90,542,006...90,566,720
Ensembl chr 3:90,542,033...90,566,713

G

translocase of outer mitochondrial membrane 34

decreases expression
multiple interactions

ISO

Benztropine results in decreased expression of TOMM34 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TOMM34 protein

NCBI chr 3:173,148,737...173,165,689
Ensembl chr 3:173,145,279...173,165,814

G

DNA topoisomerase I mitochondrial

increases expression

ISO

Benztropine results in increased expression of TOP1MT protein

NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799

G

tropomyosin 2

decreases expression

ISO

Benztropine results in decreased expression of TPM2 protein

NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726

G

tropomyosin 3

decreases expression

ISO

Benztropine results in decreased expression of TPM3 protein

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

translocated promoter region, nuclear basket protein

decreases expression

ISO

Benztropine results in decreased expression of TPR protein

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602

G

tripartite motif-containing 28

decreases expression
multiple interactions

ISO

Benztropine results in decreased expression of TRIM28 protein
[Cuprizone co-treated with Benztropine] results in increased expression of TRIM28 protein

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tetraspanin 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of TSPAN3 protein

NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844

G

tetratricopeptide repeat domain 21A

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of TTC21A protein

NCBI chr 8:128,544,684...128,580,464
Ensembl chr 8:128,544,734...128,580,086

G

tweety family member 2

increases expression

ISO

Benztropine results in increased expression of TTYH2 protein

NCBI chr10:100,208,129...100,252,505
Ensembl chr10:100,207,860...100,253,521

G

tweety family member 3

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TTYH3 protein

NCBI chr12:19,110,973...19,139,379
Ensembl chr12:19,110,824...19,139,371

G

tubulin, beta 5 class I

increases expression

ISO

Benztropine results in increased expression of TUBB protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

twinfilin actin-binding protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of TWF2 protein

NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:115,723,970...115,737,025

G

taxilin alpha

decreases expression

ISO

Benztropine results in decreased expression of TXLNA protein

NCBI chr 5:147,253,694...147,269,410
Ensembl chr 5:147,255,649...147,269,273

G

thymidylate synthetase

increases expression

ISO

Benztropine results in increased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

U2 small nuclear RNA auxiliary factor 2

decreases expression

ISO

Benztropine results in decreased expression of U2AF2 protein

NCBI chr 1:77,789,752...77,807,307
Ensembl chr 1:77,789,752...77,807,413

G

ubiquitin-like modifier activating enzyme 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of UBA2 protein

NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901

G

ubiquitin associated protein 2-like

decreases expression

ISO

Benztropine results in decreased expression of UBAP2L protein

NCBI chr 2:177,736,378...177,791,746
Ensembl chr 2:177,736,696...177,791,646

G

ubiquitin C

increases expression

ISO

Benztropine results in increased expression of UBC protein

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275

G

ubiquilin 2

decreases expression

ISO

Benztropine results in decreased expression of UBQLN2 protein

NCBI chr X:21,228,809...21,232,228
Ensembl chr X:21,229,197...21,232,268

G

ubiquitin C-terminal hydrolase L1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of UCHL1 protein

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

ubiquitin C-terminal hydrolase L3

decreases expression

ISO

Benztropine results in decreased expression of UCHL3 protein

NCBI chr15:84,888,847...84,942,095
Ensembl chr15:84,899,806...84,942,095
Ensembl chr 3:84,899,806...84,942,095

G

UDP-glucose 6-dehydrogenase

decreases expression

ISO

Benztropine results in decreased expression of UGDH protein

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629

G

unc-45 myosin chaperone B

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of UNC45B protein

NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of UQCRC2 protein

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946

G

USO1 vesicle transport factor

decreases expression

ISO

Benztropine results in decreased expression of USO1 protein

NCBI chr14:16,150,921...16,216,389
Ensembl chr14:16,150,923...16,216,389

G

ubiquitin specific peptidase 10

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of USP10 protein

NCBI chr19:64,881,255...64,923,522
Ensembl chr19:64,881,315...64,923,519

G

ubiquitin specific peptidase 14

increases expression

ISO

Benztropine results in increased expression of USP14 protein

NCBI chr18:1,292,745...1,330,867
Ensembl chr18:1,292,745...1,330,336

G

UTP18 small subunit processome component

increases expression

ISO

Benztropine results in increased expression of UTP18 protein

NCBI chr10:79,308,785...79,336,241
Ensembl chr10:79,308,787...79,336,197

G

vasodilator-stimulated phosphoprotein

decreases expression

ISO

Benztropine results in decreased expression of VASP protein

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

G

tryptophanyl-tRNA synthetase 1

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of WARS1 protein

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WD repeat domain 12

decreases expression

ISO

Benztropine results in decreased expression of WDR12 protein

NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811

G

xin actin-binding repeat containing 2

decreases expression

ISO

Benztropine results in decreased expression of XIRP2 protein

NCBI chr 3:72,534,175...72,621,056
Ensembl chr 3:72,534,146...72,621,056

G

exportin 7

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in increased expression of XPO7 protein

NCBI chr15:52,151,743...52,237,729
Ensembl chr15:52,151,743...52,237,729

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

increases expression

ISO

Benztropine results in increased expression of YWHAQ protein

NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875

G

zinc finger and BTB domain containing 42

multiple interactions

ISO

[Cuprizone co-treated with Benztropine] results in decreased expression of ZBTB42 protein

NCBI chr 6:137,559,622...137,561,750
Ensembl chr 6:137,555,304...137,570,261

G

zinc finger RNA binding protein

decreases expression

ISO

Benztropine results in decreased expression of ZFR protein

NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:62,864,338...62,929,133

G

zinc finger with KRAB and SCAN domains 7

decreases expression

ISO

Benztropine results in decreased expression of ZKSCAN7 protein

NCBI chr 8:131,379,514...131,397,065
Ensembl chr 8:131,378,013...131,397,065

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Biperiden results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

bone morphogenetic protein 6

increases expression

ISO

Biperiden results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

cholinergic receptor, muscarinic 1

multiple interactions

EXP

Biperiden binds to and results in decreased activity of CHRM1 protein

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

epiregulin

increases expression

ISO

Biperiden results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

interleukin 1 alpha

increases expression

ISO

Biperiden results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression

ISO

Biperiden results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

Biperiden results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Biperiden results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Biperiden results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

solute carrier family 7 member 11

increases expression

ISO

Biperiden results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

butylscopolamine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

ISO

Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

carbinoxamine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

solute carrier family 22 member 2

multiple interactions

ISO

carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Cinnarizine results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

dopamine receptor D2

affects binding
multiple interactions

ISO
EXP

Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]

PMID:7503767 PMID:11180191

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

parkin RBR E3 ubiquitin protein ligase

decreases response to substance

ISO

PRKN results in decreased susceptibility to Cinnarizine

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Clemastine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

histamine receptor H 1

multiple interactions

ISO

Clemastine binds to and results in decreased activity of HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Clemastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

ISO

Clozapine results in increased expression of AARS1 protein

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Clozapine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

EXP
ISO

Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein

PMID:9111066 PMID:16810505

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

EXP

Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter]

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Clozapine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 3

decreases activity

ISO

Clozapine results in decreased activity of ABCC3 protein

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

decreases activity

ISO

Clozapine results in decreased activity of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily E member 1

increases expression

ISO

Clozapine results in increased expression of ABCE1 protein

NCBI chr19:45,109,880...45,134,819
Ensembl chr19:45,109,906...45,134,819

G

ATP binding cassette subfamily G member 1

increases expression

ISO

Clozapine results in increased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ATP binding cassette subfamily G member 2

multiple interactions

ISO

Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

actin binding LIM protein family, member 2

increases expression

ISO

Clozapine results in increased expression of ABLIM2 mRNA

NCBI chr14:79,090,046...79,214,986
Ensembl chr14:79,090,923...79,214,972

G

acetyl-CoA acetyltransferase 2

increases expression

ISO

Clozapine results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

acyl-CoA thioesterase 2

increases expression

ISO

Clozapine results in increased expression of ACOT2 protein

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

acyl-CoA thioesterase 7

decreases expression

ISO

Clozapine results in decreased expression of ACOT7 protein

NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:167,968,895...168,062,033

G

acyl-CoA oxidase 1

multiple interactions

EXP

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

actin, beta

decreases expression

ISO

Clozapine results in decreased expression of ACTB protein

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

actin, beta-like 2

increases expression

ISO

Clozapine results in increased expression of ACTBL2 protein

NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:44,591,391...44,594,138

G

actin related protein 3

decreases expression

ISO

Clozapine results in decreased expression of ACTR3 protein

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

actin related protein 5

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein

NCBI chr 3:167,702,299...167,715,736
Ensembl chr 3:167,702,482...167,715,730

G

ADAM metallopeptidase domain 1a

decreases expression

EXP

Clozapine results in decreased expression of ADAM1A mRNA

NCBI chr12:40,674,460...40,680,988
Ensembl chr12:40,676,918...40,684,619

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein

NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:61,759,987...62,054,716

G

adenylate cyclase 5

affects response to substance
multiple interactions

ISO

ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232

G

adiponectin, C1Q and collagen domain containing

decreases expression
increases expression
multiple interactions

ISO
EXP

Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]

PMID:17933447 PMID:18162013 PMID:20564506

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adenosine A2a receptor

decreases expression

ISO

Clozapine results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adrenoceptor alpha 1A

multiple interactions

EXP

Clozapine binds to and results in decreased activity of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

1-acylglycerol-3-phosphate O-acyltransferase 1

decreases expression

ISO

Clozapine results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,140,565...4,149,531
Ensembl chr20:4,140,565...4,150,445

G

angiotensinogen

multiple interactions

ISO

Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

ISO

Clozapine results in increased expression of AIMP1 protein

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994

G

adenylate kinase 1

decreases expression

ISO

Clozapine results in decreased expression of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

AKT serine/threonine kinase 1

increases expression
decreases expression
increases phosphorylation

ISO
EXP

Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein

PMID:15860345 PMID:19440698

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

increases expression

EXP

Clozapine results in increased expression of AKT2 mRNA

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

albumin

multiple interactions
affects binding

EXP
ISO

Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 1 family, member A1

increases expression

ISO

Clozapine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldolase, fructose-bisphosphate A

increases expression

EXP

Clozapine results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

aldolase, fructose-bisphosphate B

increases expression
decreases expression

ISO

Clozapine results in increased expression of ALDOB protein
Clozapine results in decreased expression of ALDOB protein

PMID:34122009 PMID:36482696

NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:68,684,542...68,716,740

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA

PMID:15860345 PMID:16465460

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133

G

alkaline phosphatase, placental

multiple interactions

ISO

Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]

NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451

G

Aly/REF export factor

decreases expression

ISO

Clozapine results in decreased expression of ALYREF protein

NCBI chr10:106,369,750...106,373,395
Ensembl chr10:106,369,750...106,373,395

G

annexin A1

decreases expression

ISO

Clozapine results in decreased expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A5

decreases expression

ISO

Clozapine results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

annexin A6

decreases expression

ISO

Clozapine results in decreased expression of ANXA6 protein

NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

ISO

Clozapine results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483

G

adaptor related protein complex 2 subunit beta 1

increases expression

EXP

Clozapine results in increased expression of AP2B1 mRNA

NCBI chr10:68,596,925...68,702,547
Ensembl chr10:68,597,093...68,702,539

G

adaptor related protein complex 3 subunit beta 1

increases expression

ISO

Clozapine results in increased expression of AP3B1 protein

NCBI chr 2:27,331,241...27,535,683
Ensembl chr 2:27,334,900...27,537,702

G

apolipoprotein A5

affects response to substance

EXP

APOA5 gene polymorphism affects the susceptibility to Clozapine

NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:55,456,899...55,460,507

G

apolipoprotein D

increases expression

ISO

Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein

PMID:11158250 PMID:14647396 PMID:17266109

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

amyloid beta precursor protein

increases expression

ISO

Clozapine results in increased expression of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

activity-regulated cytoskeleton-associated protein

decreases expression

EXP

Clozapine results in decreased expression of ARC mRNA

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

Cdc42 guanine nucleotide exchange factor 9

decreases expression

ISO

Clozapine results in decreased expression of ARHGEF9 mRNA

NCBI chr X:63,929,168...64,087,267
Ensembl chr X:63,929,176...64,087,104

G

ARF like GTPase 8A

decreases expression

ISO

Clozapine results in decreased expression of ARL8A protein

NCBI chr13:49,137,632...49,146,633
Ensembl chr13:49,137,632...49,146,633

G

acidic residue methyltransferase 1

increases expression

ISO

Clozapine results in increased expression of DCPH1 protein

NCBI chr 1:43,299,916...43,323,675
Ensembl chr 1:43,299,826...43,323,670

G

actin related protein 2/3 complex, subunit 4

affects expression

ISO

Clozapine affects the expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:148,077,240...148,088,428

G

N-acylsphingosine amidohydrolase 1

increases expression

ISO

Clozapine results in increased expression of ASAH1 mRNA

PMID:15342952 PMID:17175557

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein

PMID:15342952 PMID:17175557 PMID:36482696

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartate-beta-hydroxylase

increases expression

ISO

Clozapine results in increased expression of ASPH protein

NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:27,398,949...27,611,215

G

argininosuccinate synthase 1

increases expression

ISO

Clozapine results in increased expression of ASS1 protein

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

ATPase family, AAA domain containing 3A

decreases expression

ISO

Clozapine results in decreased expression of ATAD3A protein

NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:171,632,547...171,652,725

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

ISO

Clozapine results in increased expression of ATP2A3 protein

NCBI chr10:58,079,710...58,111,279
Ensembl chr10:58,079,852...58,111,278

G

ATP synthase F1 subunit beta

decreases expression

EXP

Clozapine results in decreased expression of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

ISO

Clozapine results in increased expression of ATP5PB protein

NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387

G

ATPase H+ transporting V1 subunit A

decreases expression

ISO

Clozapine results in decreased expression of ATP6V1A protein

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit B1

decreases expression

ISO

Clozapine results in decreased expression of ATP6V1B1 protein

NCBI chr 4:117,781,444...117,800,103
Ensembl chr 4:117,781,444...117,800,103

G

ATPase H+ transporting V1 subunit B2

decreases expression

EXP
ISO

Clozapine results in decreased expression of ATP6V1B2 protein

PMID:19441803 PMID:34122009

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ataxin 10

increases expression

ISO

Clozapine results in increased expression of ATXN10 protein

NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:118,319,490...118,445,636

G

axin 2

decreases expression

EXP

Clozapine results in decreased expression of AXIN2 mRNA

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575

G

beta-secretase 2

increases expression

ISO

Clozapine results in increased expression of BACE2 protein

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:50,176,621...50,259,008

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
decreases expression

ISO
EXP

Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein

PMID:16160616 PMID:17069804

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bromodomain adjacent to zinc finger domain, 1B

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein

NCBI chr12:27,068,541...27,126,511
Ensembl chr12:27,068,541...27,126,511

G

BCAR1 scaffold protein, Cas family member

decreases expression

ISO

Clozapine results in decreased expression of BCAR1 protein

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

BCL2, apoptosis regulator

increases expression

EXP

Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 14

decreases expression

ISO

Clozapine results in decreased expression of BCL2L14 protein

NCBI chr 4:168,948,919...168,989,450
Ensembl chr 4:168,948,946...168,990,079

G

brain-derived neurotrophic factor

decreases expression
increases expression

EXP

Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein

PMID:11488957 PMID:12478621 PMID:17442489

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

Bet1 golgi vesicular membrane trafficking protein-like

decreases expression

EXP

Clozapine results in decreased expression of BET1L mRNA

NCBI chr 1:205,361,041...205,365,036
Ensembl chr 1:205,361,041...205,364,706

G

BCL2-interacting killer

multiple interactions
increases expression

ISO

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

bromodomain PHD finger transcription factor

decreases expression

ISO

Clozapine results in decreased expression of BPTF mRNA

NCBI chr10:92,480,007...92,582,485
Ensembl chr10:92,480,007...92,582,413

G

basic leucine zipper and W2 domains 1

increases expression

ISO

Clozapine results in increased expression of BZW1 protein

NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684

G

calcium voltage-gated channel subunit alpha1 A

decreases expression

ISO
EXP

Clozapine results in decreased expression of CACNA1A mRNA

PMID:14647396 PMID:16715494

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599

G

calcium binding and coiled coil domain 1

increases expression

ISO

Clozapine results in increased expression of CALCOCO1 protein

NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:135,713,208...135,727,928

G

calmodulin 2

increases expression

EXP

Clozapine results in increased expression of CALM2 mRNA

NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657

G

calreticulin

decreases expression

ISO

Clozapine results in decreased expression of CALR protein

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

calumenin

decreases expression

ISO

Clozapine results in decreased expression of CALU protein

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein

PMID:15860345 PMID:17266109 PMID:19289156

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

EXP

Clozapine results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

EXP

Clozapine results in decreased expression of CAMK2D mRNA

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

calcium/calmodulin-dependent protein kinase IV

increases expression
decreases expression

EXP

Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein

PMID:15860345 PMID:19289156

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193

G

calcium/calmodulin-dependent protein kinase kinase 1

decreases expression

EXP

Clozapine results in decreased expression of CAMKK1 protein

NCBI chr10:58,135,872...58,159,023
Ensembl chr10:58,135,915...58,159,010

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

EXP

Clozapine results in decreased expression of CAMKK2 protein

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964

G

calnexin

decreases expression

ISO

Clozapine results in decreased expression of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

cysteinyl-tRNA synthetase 1

increases expression

ISO

Clozapine results in increased expression of CARS1 protein

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

CART prepropeptide

decreases expression

EXP

Clozapine results in decreased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712

G

caspase 1

increases activity

ISO

Clozapine results in increased activity of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

increases activity
multiple interactions

ISO
EXP

Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]

PMID:22700542 PMID:24709159

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity
multiple interactions

ISO

Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

catalase

multiple interactions

ISO

Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

Clozapine results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 47

increases expression
multiple interactions

ISO

Clozapine results in increased expression of CCDC47 protein
[Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein

NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,630,106...91,648,626

G

cholecystokinin

multiple interactions
increases expression

EXP

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA

PMID:10974607 PMID:16567023

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686

G

cholecystokinin B receptor

increases expression

ISO

Clozapine results in increased expression of CCKBR mRNA

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745

G

C-C motif chemokine ligand 1

decreases expression

ISO

Clozapine results in decreased expression of CCL1 mRNA

NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790

G

cyclin D1

decreases expression

EXP

Clozapine results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D3

increases expression

EXP

Clozapine results in increased expression of CCND3 mRNA

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin L1

increases expression

EXP

Clozapine results in increased expression of CCNL1 mRNA

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468

G

chaperonin containing TCP1 subunit 7

decreases expression

ISO

Clozapine results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

Cd276 molecule

decreases expression

ISO

Clozapine results in decreased expression of CD276 protein

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

Cd63 molecule

increases expression

ISO

Clozapine results in increased expression of CD63 protein

NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,922,169...1,924,938

G

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

increases expression

ISO

Clozapine results in increased expression of CDIPT protein

NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:191,013,463...191,017,971

G

cyclin-dependent kinase 4

increases expression

EXP

Clozapine results in increased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 5

increases expression

EXP

Clozapine results in increased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

ISO

Clozapine results in increased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

ISO

Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

centromere protein V

increases expression

ISO

Clozapine results in increased expression of CENPV protein

NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,713,778...47,727,679

G

cilia and flagella associated protein 210

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein

NCBI chr 3:74,928,368...74,962,508
Ensembl chr 3:74,927,880...74,962,497

G

coiled-coil-helix-coiled-coil-helix domain containing 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein

NCBI chr12:32,464,847...32,470,871
Ensembl chr12:32,464,824...32,470,871

G

chromodomain helicase DNA binding protein 4

decreases expression

ISO

Clozapine results in decreased expression of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

chromogranin A

decreases expression
increases expression

EXP

Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA

NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:127,460,854...127,472,237

G

cell adhesion molecule L1-like

decreases expression

ISO

Clozapine results in decreased expression of CHL1 mRNA

NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:137,847,895...138,062,077

G

chimerin 1

decreases expression

ISO

Clozapine results in decreased expression of CHN1 mRNA

NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:78,917,329...79,084,197

G

cysteine and histidine rich domain containing 1

increases expression

ISO

Clozapine results in increased expression of CHORDC1 protein

NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696

G

cholinergic receptor, muscarinic 1

affects binding
increases expression
multiple interactions

ISO
EXP

Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]

PMID:11997696 PMID:16983399 PMID:18806925

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cytoskeleton-associated protein 4

increases expression

ISO

Clozapine results in increased expression of CKAP4 protein

NCBI chr 7:21,118,527...21,126,624
Ensembl chr 7:21,118,085...21,126,624

G

chloride intracellular channel 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein

NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,769,527...3,778,367

G

chloride intracellular channel 4

increases expression

ISO

Clozapine results in increased expression of CLIC4 protein

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

clock circadian regulator

affects response to substance

ISO

CLOCK gene SNP affects the susceptibility to Clozapine

NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872

G

clathrin, light chain A

decreases expression

EXP

Clozapine results in decreased expression of CLTA mRNA

NCBI chr 5:63,022,046...63,059,223
Ensembl chr 5:63,041,184...63,059,215

G

clathrin, light chain B

decreases expression

EXP

Clozapine results in decreased expression of CLTB mRNA

NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,006,656...10,024,915

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases expression
increases expression

ISO

Clozapine results in decreased expression of CNP mRNA
Clozapine results in decreased expression of CNP protein
Clozapine results in increased expression of CNP mRNA

PMID:17266109 PMID:34122009

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

coilin

increases expression

EXP

Clozapine results in increased expression of COIL mRNA

NCBI chr10:74,286,279...74,307,597
Ensembl chr10:74,286,840...74,307,595

G

collagen type V alpha 2 chain

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

catechol-O-methyltransferase

multiple interactions
affects response to substance
increases response to substance

EXP
ISO

[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine

PMID:15190105 PMID:17123785

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COP9 signalosome subunit 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein

NCBI chr10:45,117,664...45,151,868
Ensembl chr10:45,117,657...45,152,074

G

coronin 1B

decreases expression

ISO

Clozapine results in decreased expression of CORO1B protein

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:210,871,841...210,877,876

G

complexin 2

decreases expression

ISO

Clozapine results in decreased expression of CPLX2 mRNA

NCBI chr17:10,224,673...10,297,974
Ensembl chr17:10,228,449...10,297,467

G

carboxypeptidase N subunit 1

increases expression

EXP

Clozapine results in increased expression of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

copine 1

decreases expression

ISO

Clozapine results in decreased expression of CPNE1 protein

NCBI chr 3:165,047,615...165,089,994

G

carnitine palmitoyltransferase 2

multiple interactions

EXP

[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

ISO

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

corticotropin releasing hormone

decreases expression

ISO

Clozapine results in decreased expression of CRH mRNA

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

corticotropin releasing hormone binding protein

decreases expression

EXP

Clozapine results in decreased expression of CRHBP mRNA

NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:28,427,139...28,439,446

G

C-reactive protein

increases expression

ISO

Clozapine results in increased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

colony stimulating factor 3

multiple interactions

ISO

CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

casein kinase 2 alpha 1

decreases expression

EXP

Clozapine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

cystatin C

increases expression

ISO

Clozapine results in increased expression of CST3 mRNA

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

cleavage stimulation factor subunit 1

decreases expression

ISO

Clozapine results in decreased expression of CSTF1 protein

NCBI chr 3:181,562,953...181,574,727
Ensembl chr 3:181,562,955...181,574,727

G

cleavage stimulation factor subunit 2

decreases expression

ISO

Clozapine results in decreased expression of CSTF2 protein

NCBI chr X:101,546,809...101,572,760
Ensembl chr X:101,546,819...101,572,764

G

C-terminal binding protein 1

increases expression

ISO

Clozapine results in increased expression of CTBP1 protein

NCBI chr14:81,679,956...81,707,331
Ensembl chr14:81,679,765...81,707,554

G

catenin beta 1

increases expression
multiple interactions

EXP

Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

chymotrypsin-like

increases expression

EXP

Clozapine results in increased expression of CTRL mRNA

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979

G

cathepsin K

increases expression

EXP

Clozapine results in increased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cortactin

increases expression

ISO

Clozapine results in increased expression of CTTN protein

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211

G

cullin 2

increases expression

ISO

Clozapine results in increased expression of CUL2 protein

NCBI chr17:58,864,274...58,905,447
Ensembl chr17:58,864,274...58,905,132

G

cullin 3

increases expression

ISO

Clozapine results in increased expression of CUL3 protein

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427

G

C-X-C motif chemokine ligand 1

decreases expression
decreases secretion
multiple interactions
increases secretion

ISO
EXP

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein]

PMID:17346280 PMID:34935985 PMID:36482696

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

decreases secretion

ISO

Clozapine results in decreased secretion of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 3

decreases expression
decreases secretion

ISO

Clozapine results in decreased expression of CXCL1 mRNA
Clozapine results in decreased secretion of CXCL1 protein

PMID:17346280 PMID:36482696

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

similar to human chromosome X open reading frame 49

increases expression

ISO

Clozapine results in increased expression of CXORF49 protein

NCBI chr X:70,951,401...70,955,380
Ensembl chr X:70,951,410...70,955,378

G

cytochrome b5 type B

increases expression

EXP

Clozapine results in increased expression of CYB5B mRNA

NCBI chr19:51,972,611...52,006,477
Ensembl chr19:51,972,547...52,026,980

G

cytochrome b5 reductase 1

increases expression

ISO

Clozapine results in increased expression of CYB5R1 protein

NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases metabolic processing

EXP
ISO

Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Clozapine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Clozapine

PMID:18493746 PMID:18809730 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing

ISO
EXP

CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine

PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases metabolic processing
decreases activity

ISO

CYP1B1 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP1B1 protein

PMID:18809730 PMID:33814510

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases metabolic processing

ISO

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing

ISO

CYP2C8 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
increases metabolic processing
multiple interactions

ISO

CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine

PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases metabolic processing

ISO

CYP2J2 protein results in increased metabolism of Clozapine

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
decreases activity
affects metabolic processing
multiple interactions

ISO

CYP3A4 protein results in increased metabolism of Clozapine
Clozapine results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

ISO

CYP3A5 protein results in increased metabolism of Clozapine

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

DAB adaptor protein 1

increases expression

EXP

Clozapine results in increased expression of DAB1 mRNA

NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584

G

DAB adaptor protein 2

increases expression

ISO

Clozapine results in increased expression of DAB2 protein

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888

G

diacylglycerol lipase, beta

increases expression

ISO

Clozapine results in increased expression of DAGLB protein

NCBI chr12:16,173,345...16,215,777
Ensembl chr12:16,173,345...16,215,758

G

DDB1 and CUL4 associated factor 6

decreases expression

ISO

Clozapine results in decreased expression of DCAF6 mRNA

NCBI chr13:80,159,282...80,260,510
Ensembl chr13:80,159,321...80,260,510

G

doublecortin-like kinase 1

increases expression

ISO
EXP

Clozapine results in increased expression of DCLK1 mRNA

PMID:15860345 PMID:18797397

NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090

G

dopa decarboxylase

multiple interactions
increases expression

ISO

Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

DEAD-box helicase 46

increases expression

ISO

Clozapine results in increased expression of DDX46 protein

NCBI chr17:8,947,237...8,993,705
Ensembl chr17:8,947,237...8,990,247

G

DENN domain containing 10

increases expression

EXP

Clozapine results in increased expression of DENND10 mRNA

NCBI chr 1:269,937,023...269,960,506
Ensembl chr 1:269,936,895...269,962,853

G

DEPP autophagy regulator 1

increases expression

ISO

Clozapine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233

G

DiGeorge syndrome critical region gene 6

decreases expression

ISO

Clozapine results in decreased expression of DGCR6 protein

NCBI chr11:96,432,024...96,442,766
Ensembl chr11:96,432,024...96,437,255

G

diacylglycerol kinase, alpha

decreases expression

EXP

Clozapine results in decreased expression of DGKA mRNA

NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569

G

24-dehydrocholesterol reductase

increases expression

ISO

Clozapine results in increased expression of DHCR24 protein

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

7-dehydrocholesterol reductase

increases expression

ISO

Clozapine results in increased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

DExH-box helicase 30

increases expression

ISO

Clozapine results in increased expression of DHX30 protein

NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:118,943,187...118,975,592

G

DEAH-box helicase 38

decreases expression

ISO

Clozapine results in decreased expression of DHX38 protein

NCBI chr19:54,422,418...54,439,434
Ensembl chr19:54,422,418...54,439,423

G

DISC1 scaffold protein

decreases response to substance
affects response to substance

ISO

DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine

NCBI chr19:69,911,548...70,120,970
Ensembl chr19:69,911,976...70,120,970

G

dihydrolipoamide S-acetyltransferase

decreases expression
increases expression

EXP
ISO

Clozapine results in decreased expression of DLAT mRNA
Clozapine results in increased expression of DLAT protein

PMID:15860345 PMID:34122009

NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818

G

discs large MAGUK scaffold protein 2

increases expression

ISO

Clozapine results in increased expression of DLG2 protein

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

dihydrolipoamide S-succinyltransferase

decreases expression

ISO

Clozapine results in decreased expression of DLST protein

NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357

G

dynein, axonemal, heavy chain 11

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein

NCBI chr 6:144,982,130...145,298,523
Ensembl chr 6:144,973,797...145,298,692

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

ISO

Clozapine results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

double PHD fingers 1

affects expression

ISO

Clozapine affects the expression of DPF1 mRNA

NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:93,726,970...93,743,425

G

dipeptidylpeptidase 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:211,634,068...211,658,310

G

dihydropyrimidinase-like 3

decreases expression

ISO

Clozapine results in decreased expression of DPYSL3 protein

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

dihydropyrimidinase-like 4

decreases expression

ISO

Clozapine results in decreased expression of DPYSL4 protein

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523

G

down-regulator of transcription 1

decreases expression

ISO

Clozapine results in decreased expression of DR1 protein

NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,603,204...1,614,556

G

dopamine receptor D1

affects binding
decreases expression
affects response to substance

ISO
EXP

Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance

ISO
EXP

[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine

PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 More...

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

affects response to substance
multiple interactions
decreases response to substance

ISO

DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine

PMID:15579174 PMID:20029384

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

dopamine receptor D4

affects binding
multiple interactions
affects response to substance

ISO
EXP

Clozapine binds to DRD4 protein
Clozapine binds to Drd4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine

CTD
RGD

PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458

G

dystrophin related protein 2

increases expression

EXP

Clozapine results in increased expression of DRP2 mRNA alternative form

NCBI chr X:101,900,743...101,951,403
Ensembl chr X:101,901,011...101,951,403

G

dystrobrevin binding protein 1

increases response to substance
affects response to substance

ISO

DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine

NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,891,337...19,984,418

G

dual specificity phosphatase 1

decreases expression

EXP

Clozapine results in decreased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 6

decreases expression

EXP

Clozapine results in decreased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

dishevelled segment polarity protein 3

increases expression
multiple interactions

EXP

Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]

NCBI chr11:93,869,834...93,887,013
Ensembl chr11:93,869,834...93,886,903

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

ISO

Clozapine results in decreased expression of DYNC1LI1 protein

NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

ISO

Clozapine results in decreased expression of DYNC1LI2 protein

NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107

G

enhancer of mRNA decapping 4

increases expression

ISO

Clozapine results in increased expression of EDC4 protein

NCBI chr19:50,683,924...50,695,916
Ensembl chr19:50,683,897...50,697,620

G

eukaryotic translation elongation factor 1 alpha 2

increases expression

ISO

Clozapine results in increased expression of EEF1A2 protein

NCBI chr 3:188,643,455...188,652,633
Ensembl chr 3:188,643,458...188,677,712

G

eukaryotic translation elongation factor 1 delta

decreases expression

ISO

Clozapine results in decreased expression of EEF1D protein

NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:109,462,646...109,489,531

G

early growth response 1

decreases expression

EXP

Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein

PMID:17028028 PMID:18208916

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

affects expression
decreases expression

ISO
EXP

Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein

PMID:17028028 PMID:19401217

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

early growth response 3

affects response to substance

ISO

EGR3 protein affects the susceptibility to Clozapine

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

ISO

Clozapine results in increased expression of EIF2S3 protein

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:62,910,293...62,934,489

G

eukaryotic translation initiation factor 3, subunit C

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 3, subunit J

increases expression

ISO

Clozapine results in increased expression of EIF3J protein

NCBI chr 3:129,438,715...129,460,953
Ensembl chr 3:129,438,722...129,462,246

G

eukaryotic translation initiation factor 3, subunit M

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein

NCBI chr 3:111,879,589...111,897,193
Ensembl chr 3:111,870,925...111,897,193

G

eukaryotic translation initiation factor 4A3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein

NCBI chr10:105,047,567...105,057,561
Ensembl chr10:105,047,568...105,058,207

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 5B

increases expression

ISO

Clozapine results in increased expression of EIF5B protein

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583

G

eukaryotic translation initiation factor 6

decreases expression

ISO

Clozapine results in decreased expression of EIF6 protein

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:164,785,163...164,791,525

G

ETS transcription factor ELK1

decreases phosphorylation

ISO

Clozapine results in decreased phosphorylation of ELK1 protein

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

enolase 1

increases expression

EXP

Clozapine results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

enolase 3

increases expression

ISO

Clozapine results in increased expression of ENO3 protein

NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,866,101...55,874,540

G

Eph receptor A7

increases expression

ISO

Clozapine results in increased expression of EPHA7 mRNA

NCBI chr 5:47,771,776...47,925,189
Ensembl chr 5:47,771,865...47,925,058

G

Eph receptor B3

increases expression

ISO

Clozapine results in increased expression of EPHB3 protein

NCBI chr11:93,345,098...93,363,775
Ensembl chr11:93,345,098...93,363,775

G

endoplasmic reticulum aminopeptidase 1

decreases expression

ISO

Clozapine results in decreased expression of ERAP1 protein

NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:5,666,436...5,740,056

G

erb-b2 receptor tyrosine kinase 2

affects phosphorylation

EXP

Clozapine affects the phosphorylation of ERBB2 protein

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

EXP

Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein

NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772

G

ERH, mRNA splicing and mitosis factor

increases expression

ISO

Clozapine results in increased expression of ERH protein

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623

G

endoplasmic reticulum protein 44

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein

NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:67,312,098...67,406,444

G

EWS RNA-binding protein 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein

NCBI chr14:84,179,413...84,208,149
Ensembl chr14:84,179,618...84,208,095

G

exosome component 4

increases expression

ISO

Clozapine results in increased expression of EXOSC4 protein

NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:109,928,498...109,931,820

G

ezrin

decreases expression

ISO

Clozapine results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

fatty acid binding protein 1

increases expression

ISO

Clozapine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

FANCD2 and FANCI associated nuclease 1

increases expression

ISO

Clozapine results in increased expression of FAN1 protein

NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:127,330,016...127,356,400

G

phenylalanyl-tRNA synthetase subunit alpha

increases expression

ISO

Clozapine results in increased expression of FARSA protein

NCBI chr19:40,196,255...40,205,830
Ensembl chr19:40,173,716...40,205,823

G

phenylalanyl-tRNA synthetase subunit beta

increases expression

ISO

Clozapine results in increased expression of FARSB protein

NCBI chr 9:87,336,321...87,395,546
Ensembl chr 9:87,336,326...87,395,505

G

Fas cell surface death receptor

multiple interactions

ISO

[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions

ISO

[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

increases expression

ISO

Clozapine results in increased expression of FASN mRNA

PMID:16027736 PMID:17052361

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

farnesyl diphosphate synthase

increases expression

ISO

Clozapine results in increased expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

flap structure-specific endonuclease 1

increases expression

ISO

Clozapine results in increased expression of FEN1 protein

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016

G

fibroblast growth factor 2

increases expression

EXP

Clozapine results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibrinogen-like 1

increases expression

ISO

Clozapine results in increased expression of FGL1 protein

NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429

G

formin homology 2 domain containing 1

decreases expression

ISO

Clozapine results in decreased expression of FHOD1 protein

NCBI chr19:50,116,415...50,135,868
Ensembl chr19:50,116,415...50,135,330

G

FKBP prolyl isomerase 8

decreases expression

ISO

Clozapine results in decreased expression of FKBP8 protein

NCBI chr16:18,929,581...18,936,621
Ensembl chr16:18,929,582...18,936,543

G

flotillin 2

increases expression

ISO

Clozapine results in increased expression of FLOT2 protein

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:63,423,806...63,445,810

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

ISO

FMO1 protein results in increased metabolism of Clozapine

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

flavin containing dimethylaniline monoxygenase 3

increases metabolic processing

ISO

FMO3 protein results in increased metabolism of Clozapine

PMID:18809730 PMID:27320963

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256

G

fibronectin type III domain containing 4

increases expression

ISO

Clozapine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

EXP
ISO

Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine results in increased expression of FOS protein
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein

PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
decreases expression

ISO
EXP

Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA

PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

FOS like 1, AP-1 transcription factor subunit

increases expression

EXP

Clozapine results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

increases expression

EXP

Clozapine results in increased expression of FOSL2 mRNA

PMID:12093589 PMID:12243769

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box P2

increases expression

ISO

Clozapine results in increased expression of FOXP2 mRNA

NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696

G

follistatin-like 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein

NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126

G

far upstream element binding protein 1

increases expression

ISO

Clozapine results in increased expression of FUBP1 protein

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:243,819,218...243,846,428

G

glucose-6-phosphate dehydrogenase

decreases expression

ISO

Clozapine results in decreased expression of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GABA type A receptor associated protein like 2

increases expression

ISO

Clozapine results in increased expression of GABARAPL2 protein

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660

G

gamma-aminobutyric acid type B receptor subunit 1

decreases expression

ISO

Clozapine results in decreased expression of GABBR1 mRNA

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

ISO

Clozapine results in increased expression of GABRA1 mRNA

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit beta 3

increases expression

EXP

Clozapine results in increased expression of GABRB3 mRNA

NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:117,431,842...117,836,725

G

glutamate decarboxylase 1

increases expression
decreases methylation
multiple interactions

ISO
EXP

Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]

PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

glutamate decarboxylase 2

increases expression

ISO
EXP

Clozapine results in increased expression of GAD2 mRNA

PMID:17266109 PMID:18923069

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

EXP
ISO

Clozapine results in increased expression of GAPDH mRNA
Clozapine results in increased expression of GAPDH protein

PMID:15860345 PMID:34122009

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

increases expression

ISO

Clozapine results in increased expression of GART protein

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

glycine amidinotransferase

increases expression

ISO

Clozapine results in increased expression of GATM protein

NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355

G

GRIP and coiled-coil domain containing 2

decreases expression

ISO

Clozapine results in decreased expression of GCC2 protein

NCBI chr20:26,788,472...26,836,728
Ensembl chr20:26,790,516...26,836,726

G

growth differentiation factor 15

increases expression

ISO

Clozapine results in increased expression of GDF15 protein

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

ISO

Clozapine results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606

G

glial fibrillary acidic protein

decreases expression
increases expression

EXP

Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA

PMID:18585900 PMID:19441803

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

growth hormone inducible transmembrane protein

increases expression

ISO

Clozapine results in increased expression of GHITM protein

NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123

G

GTPase, IMAP family member 5

decreases expression

EXP

Clozapine results in decreased expression of GIMAP5 mRNA

NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:79,024,304...79,039,030

G

gastric inhibitory polypeptide

increases expression

EXP

Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein

NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216

G

gap junction protein, alpha 1

increases expression

EXP

Clozapine results in increased expression of GJA1 protein

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glucagon-like peptide 1 receptor

multiple interactions
decreases expression

EXP

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]

NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654

G

glutaredoxin 3

increases expression

ISO

Clozapine results in increased expression of GLRX3 protein

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glutamate-ammonia ligase

decreases expression

ISO

Clozapine results in decreased expression of GLUL protein

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

G protein subunit alpha 12

decreases expression
increases expression

EXP
ISO

Clozapine results in decreased expression of GNA12 mRNA
Clozapine results in increased expression of GNA12 protein

PMID:15860345 PMID:34122009

NCBI chr12:18,919,629...19,000,185
Ensembl chr12:18,919,629...19,000,185

G

G protein subunit alpha i1

decreases expression

EXP

Clozapine results in decreased expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha i2

decreases expression

EXP

Clozapine results in decreased expression of GNAI2 mRNA

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

G protein subunit alpha i3

decreases expression

EXP

Clozapine results in decreased expression of GNAI3 mRNA

NCBI chr 2:198,430,920...198,468,874

G

GNAS complex locus

decreases expression
multiple interactions
increases expression

EXP
ISO

Clozapine results in decreased expression of GNAS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein
Clozapine results in increased expression of GNAS protein

PMID:15860345 PMID:34122009

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536

G

G protein subunit beta 3

decreases response to substance
increases expression
affects response to substance
increases response to substance

ISO
EXP

GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine

PMID:16139171 PMID:16141801 PMID:18855531

NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:159,325,742...159,331,445

G

golgin A3

increases expression

ISO

Clozapine results in increased expression of GOLGA3 protein

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226

G

golgin B1

increases expression

ISO

Clozapine results in increased expression of GOLGB1 protein

NCBI chr11:77,348,573...77,406,165
Ensembl chr11:77,348,961...77,406,006

G

glutamic-oxaloacetic transaminase 2

increases expression
multiple interactions

EXP
ISO

Clozapine results in increased expression of GOT2 mRNA
[Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein

PMID:15860345 PMID:34122009

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111

G

glycerol-3-phosphate dehydrogenase 2

decreases expression

ISO

Clozapine results in decreased expression of GPD2 protein

NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593

G

glucose-6-phosphate isomerase

increases expression

ISO

Clozapine results in increased expression of GPI protein

NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:95,965,396...95,993,261

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases expression

ISO

Clozapine results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

EXP

Clozapine results in increased expression of GRIK2 mRNA

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202

G

glutamate ionotropic receptor kainate type subunit 5

affects expression
decreases expression

ISO
EXP

Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA

PMID:14647396 PMID:18923069

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:89,733,741...89,794,962

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA

PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

EXP

Clozapine results in decreased expression of GRIN2A mRNA

PMID:12608697 PMID:18923069

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

EXP

Clozapine results in decreased expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

EXP

Clozapine results in decreased expression of GRIN2C mRNA

NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409

G

G protein-coupled receptor kinase 6

decreases expression

EXP

Clozapine results in decreased expression of GRK6 mRNA

NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954

G

glycogen synthase kinase 3 alpha

increases expression
multiple interactions

EXP

Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]

NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593

G

glycogen synthase kinase 3 beta

increases phosphorylation
increases expression
multiple interactions

ISO
EXP

Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]

PMID:16144542 PMID:19359144 PMID:19440698

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione S-transferase alpha 1

decreases activity
increases glutathionylation

ISO

GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase mu 1

decreases activity
increases expression
increases glutathionylation

ISO
EXP

GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine

PMID:15860345 PMID:20849150

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

decreases expression

EXP

Clozapine results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

decreases activity
affects metabolic processing
increases glutathionylation
affects binding

ISO

Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein

PMID:20849150 PMID:21639118 PMID:24185126

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

H1.2 linker histone, cluster member

increases expression

ISO

Clozapine results in increased expression of H1-2 protein

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

H2A clustered histone 18

increases expression

ISO

Clozapine results in increased expression of H2AC18 mRNA

NCBI chr 2:186,497,271...186,497,865

G

H2A clustered histone 20

increases expression

ISO

Clozapine results in increased expression of H2AC20 protein

NCBI chr 2:186,468,748...186,469,226

G

H2A.J histone

increases expression

ISO

Clozapine results in increased expression of H2AJ protein

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

ISO

Clozapine results in decreased expression of HAAO protein

NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:16,598,087...16,617,356

G

3-hydroxyacyl-CoA dehydratase 3

increases expression

ISO

Clozapine results in increased expression of HACD3 protein

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:74,396,442...74,433,700

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

ISO

Clozapine results in increased expression of HADHB protein

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

histidyl-tRNA synthetase 1

increases expression

ISO

Clozapine results in increased expression of HARS1 protein

NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,655,671...28,672,712

G

histone acetyltransferase 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

hematopoietic cell specific Lyn substrate 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein

NCBI chr11:77,322,873...77,346,333
Ensembl chr11:77,322,873...77,346,387

G

HDGF like 2

increases expression

ISO

Clozapine results in increased expression of HDGFRP2 protein

NCBI chr 9:996,687...1,016,352
Ensembl chr 9:996,758...1,016,735

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

ISO

Clozapine results in increased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

high mobility group box 2

increases expression

ISO

Clozapine results in increased expression of HMGB2 protein

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases expression
increases activity

ISO

[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

Clozapine results in increased expression of HMGCS1 mRNA

PMID:16027736 PMID:17052361

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

heme oxygenase 1

increases expression

ISO

Clozapine results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

ISO

Clozapine results in decreased expression of HNRNPD protein

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066

G

heterogeneous nuclear ribonucleoprotein H2

decreases expression

ISO

Clozapine results in decreased expression of HNRNPH2 protein

NCBI chr X:102,074,175...102,080,115
Ensembl chr X:102,074,179...102,081,025

G

homer scaffold protein 1

increases expression
multiple interactions

EXP

Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]

PMID:12464447 PMID:15860345

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

hippocalcin-like 1

decreases expression

EXP

Clozapine results in decreased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

hippocalcin-like 4

affects expression

EXP

Clozapine affects the expression of HPCAL4 mRNA

NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:140,739,635...140,751,530

G

hepsin

increases expression

ISO

Clozapine results in increased expression of HPN mRNA

NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199

G

histamine receptor H 1

affects binding

ISO

Clozapine binds to HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H3

multiple interactions

EXP

Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]

RGD

NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

ISO

Clozapine results in decreased expression of HSD17B10 protein

NCBI chr X:24,568,551...24,571,012
Ensembl chr X:24,568,551...24,574,681

G

hydroxysteroid (17-beta) dehydrogenase 12

increases expression

ISO

Clozapine results in increased expression of HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938

G

heat shock protein family A (Hsp70) member 9

decreases expression

ISO

Clozapine results in decreased expression of HSPA9 protein

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

5-hydroxytryptamine receptor 1A

multiple interactions
affects binding

ISO
EXP

Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein

PMID:9723970 PMID:15482641

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 1D

decreases expression

EXP

Clozapine results in decreased expression of HTR1D mRNA

NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:153,939,516...153,960,012

G

5-hydroxytryptamine receptor 2A

increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression

ISO
EXP

HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA

PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 More...

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 2C

affects binding
decreases expression
affects response to substance

ISO
EXP

Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine

PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 More...

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

5-hydroxytryptamine receptor 3A

multiple interactions
affects response to substance

ISO

Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine

PMID:19696922 PMID:20168265

NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884

G

5-hydroxytryptamine receptor 6

multiple interactions
affects binding

ISO

Clozapine binds to and results in decreased activity of HTR6 protein
[Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein
Clozapine binds to HTR6 protein

PMID:11406289 PMID:16983399 PMID:34122009

NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

ISO

Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

PMID:14578406 PMID:20827463

NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230

G

inhibitor of DNA binding 2

increases expression

EXP

Clozapine results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Clozapine results in decreased expression of IDI1 protein

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

interferon gamma

affects expression
decreases expression

ISO

Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 1

increases expression

ISO

Clozapine results in increased expression of IFNGR1 protein

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437

G

insulin-like growth factor 1

decreases expression

ISO

Clozapine results in decreased expression of IGF1 protein

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein 1

increases expression

ISO

Clozapine results in increased expression of IGFBP1 protein

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

interleukin 10

decreases expression

EXP

Clozapine results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

increases secretion
multiple interactions

EXP

Clozapine results in increased secretion of IL1B protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2 receptor subunit alpha

increases secretion

ISO

Clozapine results in increased secretion of IL2RA protein

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 5

affects expression

ISO

Clozapine affects the expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

ILK associated serine/threonine phosphatase

decreases expression

EXP

Clozapine results in decreased expression of ILKAP mRNA

NCBI chr 9:99,413,981...99,436,262
Ensembl chr 9:99,413,978...99,436,418

G

inhibin subunit alpha

decreases expression

EXP

Clozapine results in decreased expression of INHA mRNA

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009

G

inhibin subunit beta E

increases expression

ISO

Clozapine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

insulin 2

affects secretion
increases expression

ISO

Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein

PMID:11769361 PMID:16601995

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

integrin subunit alpha 6

increases expression

ISO

Clozapine results in increased expression of ITGA6 protein

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

Janus kinase 1

increases expression

ISO

Clozapine results in increased expression of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 2

multiple interactions

EXP

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

EXP

Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA

PMID:12093589 PMID:15860345 PMID:18208916

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Clozapine results in increased expression of JUNB mRNA

PMID:12093589 PMID:19695244

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Clozapine results in decreased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

potassium voltage-gated channel subfamily A member 1

increases expression

ISO

Clozapine results in increased expression of KCNA1 mRNA

NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

ISO

Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel interacting protein 3

decreases expression
increases expression

ISO

Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216

G

potassium two pore domain channel subfamily K member 2

decreases expression

ISO

Clozapine results in decreased expression of KCNK2 mRNA

NCBI chr13:103,297,387...103,494,686
Ensembl chr13:103,297,393...103,494,686

G

potassium channel tetramerization domain containing 12

decreases expression

ISO

Clozapine results in decreased expression of KCTD12 protein

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

kinase insert domain receptor

increases expression

ISO

Clozapine results in increased expression of KDR protein

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

ISO

Clozapine results in decreased expression of KHDRBS1 protein

NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448

G

kinesin family member 13B

increases expression

ISO

Clozapine results in increased expression of KIF13B protein

NCBI chr15:43,084,059...43,241,719
Ensembl chr15:43,080,910...43,241,719

G

kinesin family member 5C

decreases expression

ISO

Clozapine results in decreased expression of KIF5C protein

NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:54,441,310...54,594,813

G

kizuna centrosomal protein

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein

NCBI chr 3:154,730,873...154,838,410
Ensembl chr 3:154,730,634...154,838,410

G

kelch domain containing 2

decreases expression

ISO

Clozapine results in decreased expression of KLHDC2 protein

NCBI chr 6:93,512,981...93,552,809
Ensembl chr 6:93,513,017...93,577,762

G

lysine methyltransferase 2A

increases expression
decreases expression
multiple interactions

ISO

Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]

PMID:14647396 PMID:17942719

NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317

G

karyopherin subunit alpha 4

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein
Clozapine results in increased expression of KPNA4 protein

NCBI chr 2:155,635,679...155,691,056
Ensembl chr 2:155,634,247...155,691,053

G

kringle containing transmembrane protein 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein

NCBI chr14:84,295,931...84,361,534
Ensembl chr14:84,297,700...84,361,614

G

lactamase, beta 2

increases expression

ISO

Clozapine results in increased expression of LACTB2 protein

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:10,352,154...10,379,255

G

lysosomal-associated membrane protein 1

increases expression

ISO

Clozapine results in increased expression of LAMP1 protein

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

increases expression

ISO

Clozapine results in increased expression of LAMTOR3 mRNA

NCBI chr 2:229,084,795...229,097,028
Ensembl chr 2:229,084,858...229,099,383

G

La ribonucleoprotein 7, transcriptional regulator

increases expression

ISO

Clozapine results in increased expression of LARP7 protein

NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:218,672,208...218,687,308

G

lipocalin 1

decreases expression

ISO

Clozapine results in decreased expression of LCN1 protein

NCBI chr 3:29,930,943...29,935,418

G

lactate dehydrogenase B

increases expression

EXP

Clozapine results in increased expression of LDHB mRNA

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

low density lipoprotein receptor

increases expression
multiple interactions

ISO

Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]

PMID:17052361 PMID:20564506

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

liver enriched antimicrobial peptide 2

increases expression

ISO

Clozapine results in increased expression of LEAP2 mRNA

NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073

G

LEM domain nuclear envelope protein 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein

NCBI chr20:5,284,275...5,298,281
Ensembl chr20:5,284,275...5,298,328

G

leptin

affects response to substance
increases expression

ISO
EXP

LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein

PMID:16402076 PMID:17502770

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

galectin 8

increases expression

ISO

Clozapine results in increased expression of LGALS8 protein

NCBI chr17:62,716,368...62,744,272
Ensembl chr17:62,719,828...62,744,482

G

lipase A, lysosomal acid type

increases expression

ISO

Clozapine results in increased expression of LIPA protein

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740

G

leiomodin 2

increases expression

ISO

Clozapine results in increased expression of LMOD2 protein

NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:54,032,974...54,040,666

G

lipoprotein lipase

decreases expression
increases expression

ISO

Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA

PMID:17266109 PMID:19682446

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LDL receptor related protein 10

increases expression

ISO

Clozapine results in increased expression of LRP10 protein

NCBI chr15:31,891,358...31,897,530
Ensembl chr15:31,891,362...31,897,528

G

leucine-rich pentatricopeptide repeat containing

increases expression

ISO

Clozapine results in increased expression of LRPPRC protein

NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:15,612,655...15,695,116

G

leucine-rich repeat kinase 2

increases expression

ISO

Clozapine results in increased expression of LRRK2 protein

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239

G

lanosterol synthase

increases expression
multiple interactions

ISO

Clozapine results in increased expression of LSS mRNA
[Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein

PMID:15342952 PMID:17175557 PMID:34122009

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

leukotriene A4 hydrolase

decreases expression

ISO

Clozapine results in decreased expression of LTA4H protein

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641

G

magnesium transporter 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein

NCBI chr X:75,104,040...75,145,247
Ensembl chr X:75,106,172...75,145,365

G

mal, T-cell differentiation protein

decreases expression

ISO

Clozapine results in decreased expression of MAL mRNA

PMID:17266109 PMID:18797397

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

monoamine oxidase B

increases expression

ISO

Clozapine results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 1A

increases expression
decreases expression

EXP
ISO

Clozapine results in increased expression of MAP1A mRNA
Clozapine results in decreased expression of MAP1A protein

PMID:15860345 PMID:34122009

NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:128,716,940...128,740,159

G

microtubule-associated protein 1B

decreases expression

ISO

Clozapine results in decreased expression of MAP1B protein

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094

G

microtubule-associated protein 1 light chain 3 beta

increases lipidation
multiple interactions

ISO

Clozapine results in increased lipidation of MAP1LC3B protein
[Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 1S

increases expression

ISO

Clozapine results in increased expression of MAP1S protein

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,551,573...18,562,141

G

mitogen activated protein kinase kinase 1

decreases expression

EXP

Clozapine results in decreased expression of MAP2K1 mRNA

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

increases expression
decreases expression

ISO
EXP

Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA

PMID:14647396 PMID:15860345

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase kinase 5

decreases expression

EXP

Clozapine results in decreased expression of MAP2K5 mRNA

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373

G

mitogen-activated protein kinase kinase kinase 1

increases expression

EXP

Clozapine results in increased expression of MAP3K1 mRNA

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen activated protein kinase kinase kinase 12

increases expression

EXP

Clozapine results in increased expression of MAP3K12 mRNA

NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:135,508,790...135,515,137

G

mitogen activated protein kinase 1

multiple interactions
decreases expression
decreases phosphorylation

ISO
EXP

Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased expression of MAPK1 mRNA
Clozapine results in decreased phosphorylation of MAPK1 protein

PMID:12871586 PMID:15860345

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 14

affects expression

EXP

Clozapine affects the expression of MAPK14 mRNA

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

ISO

Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 6

affects expression

EXP

Clozapine affects the expression of MAPK6 mRNA

NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236

G

mitogen-activated protein kinase 8 interacting protein 1

increases expression

ISO

Clozapine results in increased expression of MAPK8IP1 mRNA

NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:98,810,541...98,828,368

G

mitogen-activated protein kinase 9

affects expression

EXP

Clozapine affects the expression of MAPK9 mRNA

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microtubule-associated protein, RP/EB family, member 1

decreases expression
multiple interactions

ISO

Clozapine results in decreased expression of MAPRE1 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:162,673,195...162,711,210

G

MAS1 proto-oncogene, G protein-coupled receptor

decreases expression

EXP

Clozapine results in decreased expression of MAS1 mRNA

NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561

G

methionine adenosyltransferase 2A

decreases expression

ISO

Clozapine results in decreased expression of MAT2A protein

NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645

G

methionine adenosyltransferase 2 non-catalytic beta subunit

decreases expression

ISO

Clozapine results in decreased expression of MAT2B protein

NCBI chr10:25,609,202...25,626,694
Ensembl chr10:25,609,204...25,625,176

G

myelin basic protein

increases expression

ISO

Clozapine results in increased expression of MBP mRNA

PMID:17266109 PMID:17346280

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

melanocortin 1 receptor

increases expression

ISO

Clozapine results in increased expression of MC1R mRNA

NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877

G

mediator of DNA damage checkpoint 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein

NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,900,308...2,914,960

G

malate dehydrogenase 1

decreases expression

ISO

Clozapine results in decreased expression of MDH1 protein

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

mitofusin 2

decreases expression
multiple interactions

EXP

Clozapine results in decreased expression of MFN2 protein
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

mixed lineage kinase domain like pseudokinase

increases expression

ISO

Clozapine results in increased expression of MLKL protein

NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858

G

matrix metallopeptidase 10

decreases expression

ISO

Clozapine results in decreased expression of MMP10 mRNA

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

matrix metallopeptidase 14

increases expression

ISO

Clozapine results in increased expression of MMP14 protein

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 7

decreases expression

ISO

Clozapine results in decreased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

myelin-associated oligodendrocyte basic protein

increases expression

ISO

Clozapine results in increased expression of MOBP mRNA

PMID:15542763 PMID:17266109

NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:128,747,232...128,777,936

G

myeloperoxidase

affects response to substance
increases activity
multiple interactions
increases oxidation

ISO

MPO protein affects the susceptibility to Clozapine
Clozapine results in increased activity of MPO protein
Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid]
MPO protein results in increased oxidation of Clozapine

PMID:24588327 PMID:35575633

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

MAGUK p55 scaffold protein 3

decreases expression

ISO

Clozapine results in decreased expression of MPP3 mRNA

NCBI chr10:87,445,905...87,475,461
Ensembl chr10:87,445,905...87,474,811

G

major histocompatibility complex, class I-related

affects expression

ISO

Clozapine affects the expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

metastasis associated 1 family, member 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein

NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062

G

metadherin

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584

G

methylenetetrahydrofolate reductase

affects response to substance

ISO

MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

myeloid-associated differentiation marker

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein

NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:74,775,698...74,789,710

G

MYB binding protein 1a

increases expression

ISO

Clozapine results in increased expression of MYBBP1A protein

NCBI chr10:57,555,458...57,565,819
Ensembl chr10:57,555,452...57,566,041

G

myosin heavy chain 10

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein

NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036

G

myosin heavy chain 3

increases expression

ISO

Clozapine results in increased expression of MYH3 protein

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000

G

myosin, light chain 1

increases expression

ISO

Clozapine results in increased expression of MYL1 protein

Ensembl chr 9:75,887,227...75,907,971

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

decreases expression

ISO

Clozapine results in decreased expression of NAA10 protein

NCBI chr X:156,807,378...156,812,632
Ensembl chr X:156,807,378...156,812,574

G

nucleosome assembly protein 1-like 4

increases expression

ISO

Clozapine results in increased expression of NAP1L4 protein

NCBI chr 1:208,139,105...208,175,597
Ensembl chr 1:208,139,113...208,174,569

G

N-acetyltransferase 10

decreases expression

ISO

Clozapine results in decreased expression of NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:110,566,582...110,604,836

G

neurocan

decreases expression

ISO

Clozapine results in decreased expression of NCAN mRNA

NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371

G

non-SMC condensin I complex, subunit G

increases expression

ISO

Clozapine results in increased expression of NCAPG protein

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445

G

non-SMC condensin I complex, subunit H

decreases expression

ISO

Clozapine results in decreased expression of NCAPH protein

PMID:34122009 PMID:36482696

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502

G

nuclear cap binding protein subunit 1

decreases expression

ISO

Clozapine results in decreased expression of NCBP1 protein

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

nucleolin

increases expression

ISO

Clozapine results in increased expression of NCL mRNA

NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083

G

nuclear receptor coactivator 4

increases expression

ISO

Clozapine results in increased expression of NCOA4 protein

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

EXP

Clozapine results in increased expression of NDUFV2 mRNA

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

nectin cell adhesion molecule 2

decreases expression

ISO

Clozapine results in decreased expression of NECTIN2 protein

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

ISO

Clozapine results in decreased expression of NEDD4 mRNA

NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633

G

nestin

decreases expression

ISO

Clozapine results in decreased expression of NES protein

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

NFE2 like bZIP transcription factor 2

affects response to substance

ISO

NFE2L2 protein affects the susceptibility to Clozapine

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

decreases expression

EXP

Clozapine results in decreased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nerve growth factor receptor

decreases expression

ISO
EXP

Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA

PMID:12111809 PMID:14598305 PMID:16513140

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

nucleolar protein interacting with the FHA domain of MKI67

decreases expression

ISO

Clozapine results in decreased expression of NIFK protein

NCBI chr13:31,946,119...31,955,950
Ensembl chr13:31,946,108...31,959,561

G

nicotinamide N-methyltransferase

increases expression

ISO

Clozapine results in increased expression of NNMT protein

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174

G

nicotinamide nucleotide transhydrogenase

decreases expression

ISO

Clozapine results in decreased expression of NNT protein

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:53,144,160...53,237,310

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

ISO

Clozapine results in increased expression of NOC2L protein

NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:172,101,223...172,114,162

G

Nodal modulator 1

increases expression

ISO

Clozapine results in increased expression of NOMO3 protein

NCBI chr 1:105,641,867...105,692,708
Ensembl chr 1:105,641,879...105,692,707

G

NOP53 ribosome biogenesis factor

affects expression

ISO

Clozapine affects the expression of NOP53 mRNA

NCBI chr 1:85,757,271...85,765,089
Ensembl chr 1:85,756,586...85,765,089

G

notch receptor 2

increases expression

ISO

Clozapine results in increased expression of NOTCH2 protein

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823

G

NPL4 homolog, ubiquitin recognition factor

decreases expression

ISO

Clozapine results in decreased expression of NPLOC4 protein

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264

G

neuroplastin

increases expression

ISO

Clozapine results in increased expression of NPTN mRNA

NCBI chr 8:67,892,678...67,959,231
Ensembl chr 8:67,892,702...67,959,236

G

neuronal pentraxin 2

decreases expression

EXP

Clozapine results in decreased expression of NPTX2 mRNA

NCBI chr12:15,151,136...15,162,045
Ensembl chr12:15,151,136...15,162,045

G

neuropeptide Y

decreases expression

EXP

Clozapine results in decreased expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

affects response to substance
increases reduction
multiple interactions

ISO

NQO2 gene SNP affects the susceptibility to Clozapine
NQO2 protein results in increased reduction of Clozapine metabolite
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]

PMID:14617031 PMID:29281794

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 0, group B, member 2

increases expression

ISO

Clozapine results in increased expression of NR0B2 mRNA

PMID:15342952 PMID:17175557

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

ISO

Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

increases expression
decreases expression

EXP

Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA

PMID:10987852 PMID:11564422 PMID:19695244

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

increases expression

ISO

Clozapine results in increased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

neuregulin 1

increases expression
affects expression
affects response to substance

ISO
EXP

Clozapine results in increased expression of NRG1 mRNA
Clozapine affects the expression of NRG1 protein
NRG1 protein affects the susceptibility to Clozapine

PMID:15706234 PMID:18184445 PMID:19502011

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

ISO

Clozapine results in decreased expression of NSF protein

NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621

G

netrin G2

increases expression

EXP

Clozapine results in increased expression of NTNG2 mRNA

NCBI chr 3:32,889,856...32,949,032
Ensembl chr 3:32,890,575...32,943,821

G

neurotensin

increases expression

EXP

Clozapine results in increased expression of NTS mRNA

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

G

nuclear mitotic apparatus protein 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein

NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848

G

NUMB-like, endocytic adaptor protein

decreases expression

ISO

Clozapine results in decreased expression of NUMBL mRNA

NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424

G

nucleoporin 160

increases expression

ISO

Clozapine results in increased expression of NUP160 protein

NCBI chr 3:97,120,723...97,183,227
Ensembl chr 3:97,121,628...97,180,720

G

nucleoporin 50

increases expression

ISO

Clozapine results in increased expression of NUP50 protein

NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:117,925,716...117,946,959

G

nucleoporin 54

decreases expression

ISO

Clozapine results in decreased expression of NUP54 protein

NCBI chr14:15,901,936...15,920,335
Ensembl chr14:15,901,991...15,920,334

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

Clozapine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

oxysterol binding protein-like 8

increases expression

ISO

Clozapine results in increased expression of OSBPL8 mRNA

NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151

G

oxytocin/neurophysin I prepropeptide

affects response to substance

ISO

OXT protein affects the susceptibility to Clozapine

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594

G

paralemmin A kinase anchor protein

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein

NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656

G

pantothenate kinase 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein

NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,733,127...20,757,015

G

Parkinsonism associated deglycase

increases expression

ISO

Clozapine results in increased expression of PARK7 mRNA

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

poly(rC) binding protein 1

increases expression

ISO

Clozapine results in increased expression of PCBP1 protein

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

decreases expression

ISO

Clozapine results in decreased expression of PCK2 protein

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

piccolo (presynaptic cytomatrix protein)

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein

NCBI chr 4:20,646,604...21,005,171
Ensembl chr 4:20,646,604...21,005,111

G

pericentriolar material 1

decreases expression

ISO

Clozapine results in decreased expression of PCM1 mRNA

NCBI chr16:57,711,833...57,808,842
Ensembl chr16:57,711,833...57,808,599

G

PEST proteolytic signal containing nuclear protein

increases expression

ISO

Clozapine results in increased expression of PCNP protein

NCBI chr11:58,061,885...58,076,436
Ensembl chr11:58,061,570...58,076,436

G

proprotein convertase subtilisin/kexin type 1 inhibitor

affects expression

ISO

Clozapine affects the expression of PCSK1N mRNA

NCBI chr X:17,251,963...17,255,405
Ensembl chr X:17,251,965...17,257,360

G

programmed cell death 11

increases expression

ISO

Clozapine results in increased expression of PDCD11 protein

NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336

G

phosphodiesterase 10A

increases expression

ISO
EXP

Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein

PMID:17266109 PMID:18222493

NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051

G

phosphodiesterase 1B

increases expression

ISO

Clozapine results in increased expression of PDE1B mRNA

NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033

G

phosphodiesterase 4A

decreases expression

EXP

Clozapine results in decreased expression of PDE4A protein

NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924

G

phosphodiesterase 4B

decreases expression
increases expression

EXP

Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein

PMID:18222493 PMID:20222156

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

protein disulfide isomerase family A, member 3

decreases expression

ISO

Clozapine results in decreased expression of PDIA3 protein

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 4

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein

NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191

G

PDZ and LIM domain 5

decreases expression

ISO

Clozapine results in decreased expression of PDLIM5 protein

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

phosphatidylethanolamine binding protein 1

decreases expression

ISO

Clozapine results in decreased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

proenkephalin

decreases expression
increases expression

EXP

Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA

PMID:1635659 PMID:12887421

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705

G

prefoldin subunit 5

increases expression

ISO

Clozapine results in increased expression of PFDN5 mRNA

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099

G

phosphofructokinase, platelet

increases expression

EXP

Clozapine results in increased expression of PFKP mRNA

NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752

G

PGAM family member 5, mitochondrial serine/threonine protein phosphatase

decreases expression

ISO

Clozapine results in decreased expression of PGAM5 protein

NCBI chr12:52,069,023...52,076,131
Ensembl chr12:52,069,103...52,076,131

G

phosphoglycerate kinase 1

increases expression

EXP

Clozapine results in increased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

progesterone receptor membrane component 1

multiple interactions

EXP

PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein]

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

phosphatase and actin regulator 1

increases expression

ISO

Clozapine results in increased expression of PHACTR1 mRNA

NCBI chr17:21,769,006...22,246,227
Ensembl chr17:21,768,662...22,244,586

G

PHD finger protein 14

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

EXP

Clozapine results in decreased expression of PIK3R3 mRNA

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762

G

phosphatidylinositol transfer protein, beta

increases expression

ISO

Clozapine results in increased expression of PITPNB protein

NCBI chr12:50,909,140...50,958,193
Ensembl chr12:50,909,143...50,958,140

G

cAMP-dependent protein kinase inhibitor beta

decreases expression

EXP

Clozapine results in decreased expression of PKIB mRNA

NCBI chr20:37,511,564...37,608,607
Ensembl chr20:37,512,822...37,608,401

G

pyruvate kinase M1/2

increases expression

EXP

Clozapine results in increased expression of PKM mRNA

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase C beta 1

increases expression

ISO

Clozapine results in increased expression of PLCB1 mRNA

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

proteolipid protein 1

decreases expression
increases expression

ISO

Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA

PMID:17266109 PMID:18797397

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:104,975,780...104,993,314

G

plastin 3

decreases expression

ISO

Clozapine results in decreased expression of PLS3 protein

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

PNMA family member 1

increases expression

ISO

Clozapine results in increased expression of PNMA1 protein

NCBI chr 6:109,513,382...109,515,167
Ensembl chr 6:109,507,773...109,515,451

G

paraoxonase 3

increases expression

ISO

Clozapine results in increased expression of PON3 protein

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

inorganic pyrophosphatase 1

increases expression

ISO

Clozapine results in increased expression of PPA1 protein

NCBI chr20:30,132,088...30,160,492
Ensembl chr20:30,133,504...30,160,489

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

decreases expression

EXP

Clozapine results in decreased expression of PPM1A mRNA

NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

decreases expression

EXP

Clozapine results in decreased expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756

G

protein phosphatase 1 catalytic subunit beta

decreases expression

EXP

Clozapine results in decreased expression of PPP1CB mRNA

NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924

G

protein phosphatase 1 catalytic subunit gamma

decreases expression

EXP

Clozapine results in decreased expression of PPP1CC mRNA

NCBI chr12:40,043,822...40,061,301
Ensembl chr12:40,043,822...40,061,341

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

decreases expression

ISO

Clozapine results in decreased expression of PPP1R14B protein

NCBI chr 1:213,594,416...213,596,527
Ensembl chr12:21,088,517...21,101,431
Ensembl chr 1:21,088,517...21,101,431

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

decreases expression

EXP

Clozapine results in decreased expression of PPP1R1A mRNA

NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:136,523,604...136,540,683

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions
increases phosphorylation

ISO

Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein

PMID:11880652 PMID:12871586

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

decreases expression

EXP

Clozapine results in decreased expression of PPP1R2 mRNA

NCBI chr11:82,977,634...82,999,426
Ensembl chr11:82,977,515...83,001,083

G

protein phosphatase 1, regulatory subunit 9B

increases expression

EXP

Clozapine results in increased expression of PPP1R9B protein

NCBI chr10:80,434,888...80,450,919
Ensembl chr10:80,434,900...80,450,919

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

EXP

Clozapine results in decreased expression of PPP2CA mRNA

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 2 catalytic subunit beta

decreases expression

EXP

Clozapine results in decreased expression of PPP2CB mRNA

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

EXP

Clozapine results in increased expression of PPP2R1A mRNA

NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242

G

protein phosphatase 2, regulatory subunit B, alpha

decreases expression

EXP

Clozapine results in decreased expression of PPP2R2A mRNA

NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405

G

protein phosphatase 3 catalytic subunit alpha

multiple interactions
increases expression
decreases expression

EXP

[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein

PMID:12437575 PMID:16033416

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

protein phosphatase 4, regulatory subunit 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein

NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844

G

protein phosphatase 5, catalytic subunit

affects expression

ISO

Clozapine affects the expression of PPP5C mRNA

NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950

G

peroxiredoxin 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

protein kinase cAMP-activated catalytic subunit alpha

increases expression

EXP

Clozapine results in increased expression of PRKACA mRNA

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

protein kinase cAMP-activated catalytic subunit beta

decreases expression
increases expression

EXP

Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA

PMID:11907174 PMID:15860345

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase cAMP-dependent type II regulatory subunit alpha

multiple interactions
decreases expression

EXP
ISO

Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
[Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein

PMID:11907174 PMID:34122009

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330

G

protein kinase cAMP-dependent type II regulatory subunit beta

decreases expression
multiple interactions

EXP

Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]

PMID:11907174 PMID:15860345

NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:54,291,151...54,381,411

G

protein kinase C, beta

affects expression
increases expression

EXP

Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA

PMID:15860345 PMID:15967061

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, epsilon

increases expression

EXP

Clozapine results in increased expression of PRKCE mRNA

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, zeta

increases expression

EXP

Clozapine results in increased expression of PRKCZ mRNA

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

prolactin

increases secretion
increases expression
multiple interactions

ISO
EXP

Clozapine results in increased secretion of PRL protein
Clozapine analog results in increased expression of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein

PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protein arginine methyltransferase 1

decreases expression

ISO

Clozapine results in decreased expression of PRMT1 protein

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827

G

protein C, inactivator of coagulation factors Va and VIIIa

increases expression

ISO

Clozapine results in increased expression of PROC protein

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

pre-mRNA processing factor 38B

decreases expression

ISO

Clozapine results in decreased expression of PRPF38B mRNA

NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:199,241,313...199,250,338

G

pre-mRNA processing factor 6

decreases expression
multiple interactions

ISO

Clozapine results in decreased expression of PRPF6 protein
[Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein

NCBI chr 3:189,084,465...189,148,705
Ensembl chr 3:189,081,794...189,152,786

G

proline-rich coiled-coil 2A

decreases expression

ISO

Clozapine results in decreased expression of PRRC2A mRNA

NCBI chr20:3,660,981...3,686,715
Ensembl chr20:3,663,400...3,678,778

G

proteasome 20S subunit beta 5

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein

NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379

G

proteasome 20S subunit beta 7

decreases expression

ISO

Clozapine results in decreased expression of PSMB7 protein

NCBI chr 3:42,767,500...42,827,470
Ensembl chr 3:42,767,501...42,827,601

G

proteasome 26S subunit, ATPase 3

increases expression

ISO

Clozapine results in increased expression of PSMC3 protein

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 5

increases expression

ISO

Clozapine results in increased expression of PSMC5 protein

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 14

increases expression

ISO

Clozapine results in increased expression of PSMD14 protein

NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665

G

proteasome 26S subunit, non-ATPase 7

increases expression

ISO

Clozapine results in increased expression of PSMD7 protein

NCBI chr19:52,404,032...52,411,316
Ensembl chr19:52,404,032...52,417,871

G

Pentatricopeptide repeat domain 3

increases expression

ISO

Clozapine results in increased expression of PTCD3 protein

NCBI chr 4:105,480,699...105,508,007
Ensembl chr 4:105,480,709...105,513,276

G

prostaglandin D2 synthase

decreases expression
increases expression

ISO

Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA

PMID:15542763 PMID:17266109

NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978

G

protein tyrosine kinase 2

increases expression

ISO

Clozapine results in increased expression of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

prothymosin alpha

increases expression

ISO

Clozapine results in increased expression of PTMA protein

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276

G

parathymosin

increases expression

ISO

Clozapine results in increased expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212

G

parvalbumin

multiple interactions

EXP

Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]

NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446

G

PWP2, small subunit processome component

increases expression

ISO

Clozapine results in increased expression of PWP2 protein

NCBI chr20:10,498,998...10,512,631
Ensembl chr20:10,499,013...10,513,309

G

pyrroline-5-carboxylate reductase 1

increases expression

ISO

Clozapine results in increased expression of PYCR1 protein

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

quinoid dihydropteridine reductase

decreases expression

ISO

Clozapine results in decreased expression of QDPR protein

NCBI chr14:69,882,776...69,896,378
Ensembl chr14:69,882,612...69,896,379

G

RAB12, member RAS oncogene family

decreases expression

EXP

Clozapine results in decreased expression of RAB12 mRNA

NCBI chr 9:113,927,119...113,953,722
Ensembl chr 9:113,927,119...113,953,695

G

Rac family small GTPase 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

receptor for activated C kinase 1

decreases expression

ISO

Clozapine results in decreased expression of RACK1 protein

NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948

G

RALY RNA binding protein-like

increases expression

ISO

Clozapine results in increased expression of RALYL protein

NCBI chr 2:89,390,212...90,181,681
Ensembl chr 2:89,390,129...90,181,624

G

RAN, member RAS oncogene family

decreases expression

ISO

Clozapine results in decreased expression of RAN protein

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317

G

Rap1 GTPase-GDP dissociation stimulator 1

increases expression

ISO

Clozapine results in increased expression of RAP1GDS1 protein

NCBI chr 2:230,173,713...230,318,555
Ensembl chr 2:230,173,713...230,318,538

G

Rap guanine nucleotide exchange factor 4

decreases expression

ISO

Clozapine results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression

EXP

Clozapine affects the expression of RASGRF1 mRNA

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

RB binding protein 4, chromatin remodeling factor

decreases expression

ISO

Clozapine results in decreased expression of RBBP4 protein

NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:146,922,611...146,959,501

G

RELA proto-oncogene, NF-kB subunit

decreases expression

EXP

Clozapine results in decreased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

reelin

decreases expression
multiple interactions
decreases methylation

ISO
EXP

Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased expression of RELN protein
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]

PMID:17266109 PMID:18757738 PMID:19359144

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

replication factor C subunit 5

increases expression

ISO

Clozapine results in increased expression of RFC5 protein

NCBI chr12:44,868,322...44,877,879
Ensembl chr12:44,862,329...44,878,151

G

regulator of G-protein signaling 4

increases expression

EXP
ISO

Clozapine results in increased expression of RGS4 mRNA

PMID:15860345 PMID:17266109

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

regulator of G-protein signaling 7

multiple interactions
increases expression

EXP

[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA

NCBI chr13:89,511,492...89,941,082
Ensembl chr13:89,511,150...89,940,987

G

regulator of G-protein signaling 8

increases expression

EXP

Clozapine results in increased expression of RGS8 mRNA

NCBI chr13:68,355,078...68,399,412
Ensembl chr13:68,355,157...68,399,412

G

ras homolog family member B

increases expression

ISO

Clozapine results in increased expression of RHOB protein

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

RIC8 guanine nucleotide exchange factor A

decreases expression

ISO

Clozapine results in decreased expression of RIC8A protein

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:205,363,882...205,371,102

G

ring finger protein 13

increases expression

ISO

Clozapine results in increased expression of RNF13 protein

NCBI chr 2:144,076,526...144,211,520
Ensembl chr 2:144,077,916...144,211,798

G

ring finger protein 20

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein

NCBI chr 5:68,771,507...68,797,240
Ensembl chr 5:68,771,535...68,797,240

G

RAR-related orphan receptor B

decreases expression

EXP

Clozapine results in decreased expression of RORB mRNA

NCBI chr 1:225,790,216...225,970,973
Ensembl chr 1:225,790,216...225,970,973

G

replication protein A1

decreases expression

ISO

Clozapine results in decreased expression of RPA1 protein

NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,647,185...60,698,279

G

ribosomal protein L11

increases expression

ISO

Clozapine results in increased expression of RPL11 protein

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal protein L19

increases expression

ISO

Clozapine results in increased expression of RPL19 protein

NCBI chr10:83,514,509...83,522,352
Ensembl chr10:83,515,464...83,522,352

G

ribosomal protein L30

increases expression

ISO

Clozapine results in increased expression of RPL30 protein

NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:67,465,332...67,536,555

G

ribosomal protein L5

increases expression

ISO

Clozapine results in increased expression of RPL5 protein

NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225

G

ribosomal protein lateral stalk subunit P0 like 1

decreases expression

ISO

Clozapine results in decreased expression of RPLP0P6 protein

NCBI chr 2:194,609,881...194,611,022
Ensembl chr 2:194,609,950...194,611,022

G

ribosomal protein lateral stalk subunit P2

increases expression

ISO

Clozapine results in increased expression of RPLP2 mRNA

NCBI chr 1:205,975,598...205,978,192
Ensembl chr 1:205,975,894...205,978,191

G

ribophorin II

decreases expression

ISO

Clozapine results in decreased expression of RPN2 protein

NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922

G

ribosomal protein S10

increases expression

ISO

Clozapine results in increased expression of RPS10 mRNA

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S11

decreases expression

ISO

Clozapine results in decreased expression of RPS11 protein

NCBI chr 1:104,742,153...104,744,261
Ensembl chr 1:104,742,155...104,744,337

G

ribosomal protein S3

decreases expression

ISO

Clozapine results in decreased expression of RPS3 protein

NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:163,189,842...163,195,776

G

ribosome binding protein 1

decreases expression

ISO

Clozapine results in decreased expression of RRBP1 protein

NCBI chr 3:151,768,386...151,830,255
Ensembl chr 3:151,768,386...151,830,255

G

remodeling and spacing factor 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein

NCBI chr 1:161,303,596...161,426,326
Ensembl chr 1:161,303,660...161,420,290

G

ring finger and SPRY domain containing 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein

NCBI chr19:10,358,423...10,408,988
Ensembl chr19:10,359,795...10,407,076

G

RT1 class Ia, locus A2

increases expression

ISO

Clozapine results in increased expression of HLA-E protein

NCBI chr20:4,872,720...4,876,425

G

RNA 2',3'-cyclic phosphate and 5'-OH ligase

increases expression

ISO

Clozapine results in increased expression of RTCB protein

NCBI chr 7:19,795,393...19,814,875
Ensembl chr 7:19,795,393...19,814,875

G

reticulon 4

increases expression

ISO

Clozapine results in increased expression of RTN4 mRNA

NCBI chr14:107,651,001...107,698,610
Ensembl chr14:107,650,732...107,698,611

G

retinoid X receptor gamma

decreases expression

EXP

Clozapine results in decreased expression of RXRG mRNA alternative form

NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095

G

S100 calcium binding protein A9

decreases expression

ISO

Clozapine results in decreased expression of S100A9 mRNA

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

scaffold attachment factor B

increases expression

ISO

Clozapine results in increased expression of SAFB protein

NCBI chr 9:1,504,657...1,525,545
Ensembl chr 9:1,504,456...1,525,781

G

seryl-tRNA synthetase 1

decreases expression

ISO

Clozapine results in decreased expression of SARS1 protein

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365

G

SATB homeobox 2

increases expression

ISO

Clozapine results in increased expression of SATB2 protein

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:65,844,570...66,021,238

G

sterol-C5-desaturase

increases expression

ISO

Clozapine results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

stearoyl-CoA desaturase

increases expression

ISO

Clozapine results in increased expression of SCD mRNA

PMID:16027736 PMID:17052361

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

syndecan binding protein

decreases expression
increases expression

ISO

Clozapine results in decreased expression of SDCBP protein
Clozapine results in increased expression of SDCBP protein

PMID:34122009 PMID:36482696

NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:24,245,033...24,326,197

G

secretory blood group 1

decreases expression
increases expression

EXP

Clozapine results in decreased expression of SEC1 mRNA
Clozapine results in increased expression of SEC1 mRNA

NCBI chr 1:105,287,093...105,301,588
Ensembl chr 1:105,287,443...105,301,793

G

SEC31 homolog A, COPII coat complex component

increases expression

ISO

Clozapine results in increased expression of SEC31A protein

NCBI chr14:9,518,655...9,573,579
Ensembl chr14:9,518,648...9,573,585

G

SEC61 translocon subunit beta

increases expression

ISO

Clozapine results in increased expression of SEC61B protein

NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028

G

SEC63 homolog, protein translocation regulator

increases expression

ISO

Clozapine results in increased expression of SEC63 protein

NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248

G

septin 14

decreases expression

ISO

Clozapine results in decreased expression of SEPTIN14 protein

NCBI chr12:32,610,600...32,641,391
Ensembl chr12:32,611,434...32,641,391

G

serine incorporator 1

increases expression

ISO

Clozapine results in increased expression of SERINC1 protein

NCBI chr20:37,396,497...37,415,433
Ensembl chr20:37,396,497...37,443,124

G

serpin family A member 3N

increases expression

ISO

Clozapine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family E member 2

increases expression

EXP

Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202

G

Set nuclear proto-oncogene

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of SET protein

NCBI chr 3:33,732,319...33,743,433

G

senataxin

increases expression

ISO

Clozapine results in increased expression of SETX protein

NCBI chr 3:32,825,771...32,878,740
Ensembl chr 3:32,828,412...32,878,740

G

splicing factor 3b, subunit 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein

NCBI chr19:55,692,124...55,729,640
Ensembl chr19:55,692,126...55,729,621

G

splicing factor proline and glutamine rich

decreases expression

ISO

Clozapine results in decreased expression of SFPQ protein

NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926

G

sideroflexin 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

serum/glucocorticoid regulated kinase 1

increases expression

ISO
EXP

Clozapine results in increased expression of SGK1 mRNA

PMID:17266109 PMID:18208916

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

SH3 domain containing GRB2 like 1, endophilin A2

increases expression

ISO

Clozapine results in increased expression of SH3GL1 protein

NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890

G

SH3 domain-containing kinase-binding protein 1

increases expression

ISO

Clozapine results in increased expression of SH3KBP1 protein

NCBI chr X:38,686,530...39,031,658
Ensembl chr X:38,686,530...39,031,393

G

SH3 and PX domains 2B

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein

NCBI chr10:17,422,906...17,538,977
Ensembl chr10:17,422,947...17,512,854

G

SIM bHLH transcription factor 2

decreases expression

ISO

Clozapine results in decreased expression of SIM2 protein

NCBI chr11:46,883,859...46,923,305
Ensembl chr11:46,883,859...46,923,305

G

sirtuin 2

increases expression

ISO

Clozapine results in increased expression of SIRT2 protein

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499

G

S-phase kinase-associated protein 1

decreases expression

ISO

Clozapine results in decreased expression of SKP1 protein

NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,903,078...36,918,308

G

solute carrier family 17 member 6

increases expression

ISO

Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein

PMID:17266109 PMID:18155072

NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498

G

solute carrier family 17 member 7

increases expression

ISO

Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 18 member A2

increases expression

EXP

Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 1

decreases expression

EXP

Clozapine results in decreased expression of SLC1A1 mRNA

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469

G

solute carrier family 1 member 2

decreases activity
decreases expression

EXP

Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein

PMID:11443521 PMID:12873733

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 22 member 2

multiple interactions

ISO

Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

ISO

Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 25 member 13

increases expression

ISO

Clozapine results in increased expression of SLC25A13 protein

NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:35,145,721...35,328,360

G

solute carrier family 25 member 24

increases expression

ISO

Clozapine results in increased expression of SLC25A24 protein

NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:199,449,345...199,487,290

G

solute carrier family 25 member 5, pseudogene 11

increases expression

ISO

Clozapine results in increased expression of SLC25A6 protein

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597

G

solute carrier family 2 member 3

decreases expression

ISO

Clozapine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 39 member 7

increases expression

ISO

Clozapine results in increased expression of SLC39A7 mRNA

NCBI chr20:4,824,967...4,828,431
Ensembl chr20:4,824,688...4,828,430

G

solute carrier family 3 member 2

increases expression

ISO

Clozapine results in increased expression of SLC3A2 protein

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 2

decreases expression

EXP

Clozapine results in decreased expression of SLC6A2 mRNA

NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348

G

solute carrier family 6 member 3

affects response to substance

ISO

SLC6A3 5' UTR affects the susceptibility to Clozapine

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

multiple interactions
increases expression
affects response to substance

ISO
EXP

[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4
SLC6A4 protein affects the susceptibility to Clozapine

PMID:12007678 PMID:20452607

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier organic anion transporter family member 1B2

decreases activity

ISO

Clozapine results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

ISO

Clozapine results in decreased expression of SMARCB1 protein

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055

G

SWI/SNF related BAF chromatin remodeling complex subunit C2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein

NCBI chr 7:1,466,223...1,494,627
Ensembl chr 7:1,466,454...1,494,626

G

structural maintenance of chromosomes 2

decreases expression

ISO

Clozapine results in decreased expression of SMC2 protein

NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:71,602,308...71,648,632

G

structural maintenance of chromosomes 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SMC3 protein

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:262,607,080...262,649,825

G

synaptosome associated protein 25

increases expression
affects response to substance

EXP
ISO

Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine

PMID:15823421 PMID:15860345

NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448

G

small nuclear ribonucleoprotein U5 subunit 200

increases expression

ISO

Clozapine results in increased expression of SNRNP200 protein

NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:134,882,173...134,911,500

G

small nuclear ribonucleoprotein polypeptides B and B1

increases expression

ISO

Clozapine results in increased expression of SNRPB protein

NCBI chr 3:137,824,870...137,832,479
Ensembl chr 3:137,824,683...137,832,515

G

small nuclear ribonucleoprotein D2 polypeptide

increases expression

ISO

Clozapine results in increased expression of SNRPD2 mRNA

NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:87,926,048...87,933,339
Ensembl chr20:87,926,048...87,933,339

G

sorting nexin 1

decreases expression

ISO

Clozapine results in decreased expression of SNX1 protein

NCBI chr 8:75,515,780...75,565,487
Ensembl chr 8:75,525,181...75,565,561

G

sorting nexin 6

increases expression

ISO

Clozapine results in increased expression of SNX6 protein

NCBI chr 6:77,966,141...78,009,343
Ensembl chr 6:77,965,819...78,051,290

G

superoxide dismutase 1

increases expression
decreases expression
multiple interactions

EXP
ISO

Clozapine results in increased expression of SOD1 mRNA
Clozapine results in decreased expression of SOD1 protein
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]

PMID:12111809 PMID:12752374 PMID:16564057 PMID:34122009

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

decreases expression

EXP

Clozapine results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

increases expression

EXP

Clozapine results in increased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression
increases expression

EXP

Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

secreted phosphoprotein 1

decreases expression

ISO

Clozapine results in decreased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

serine palmitoyltransferase, long chain base subunit 1

decreases expression

ISO

Clozapine results in decreased expression of SPTLC1 protein

NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234

G

sequestosome 1

increases expression

ISO

Clozapine results in increased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sterol regulatory element binding transcription factor 1

increases expression
multiple interactions

ISO

Clozapine results in increased expression of SREBF1 mRNA
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]

PMID:17052361 PMID:19682446 PMID:20564506

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sterol regulatory element binding transcription factor 2

multiple interactions
increases expression

ISO

Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

serine/arginine repetitive matrix 2

decreases expression

ISO

Clozapine results in decreased expression of SRRM2 protein

NCBI chr10:13,320,059...13,353,337
Ensembl chr10:13,320,059...13,353,337

G

serine and arginine rich splicing factor 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of SRSF2 protein

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

serine and arginine rich splicing factor 5

multiple interactions
increases expression

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of SRSF5 protein
Clozapine results in increased expression of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

serine and arginine rich splicing factor 7

decreases expression

ISO

Clozapine results in decreased expression of SRSF7 protein

NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212

G

signal sequence receptor subunit 3

decreases expression

ISO

Clozapine results in decreased expression of SSR3 protein

NCBI chr 2:151,915,101...151,935,162
Ensembl chr 2:151,906,149...151,935,170

G

somatostatin

multiple interactions

EXP

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823

G

stromal interaction molecule 1

decreases expression

ISO

Clozapine results in decreased expression of STIM1 protein

NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:166,067,962...166,233,108

G

stress-induced phosphoprotein 1

decreases expression

ISO

Clozapine results in decreased expression of STIP1 protein

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

serine/threonine kinase receptor associated protein

decreases expression

ISO

Clozapine results in decreased expression of STRAP protein

NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:172,377,305...172,392,436

G

striatin 4

increases expression

ISO

Clozapine results in increased expression of STRN4 mRNA

NCBI chr 1:86,614,193...86,639,959
Ensembl chr 1:86,610,210...86,639,955

G

syntaxin 1A

increases expression

EXP

Clozapine results in increased expression of STX1A mRNA

NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471

G

syntaxin 1B

increases expression

EXP

Clozapine results in increased expression of STX1B mRNA

NCBI chr 1:191,846,016...191,864,878
Ensembl chr 1:191,833,743...191,871,633

G

syntaxin 4

increases expression

EXP

Clozapine results in increased expression of STX4 mRNA

NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774

G

syntaxin 8

affects expression

EXP

Clozapine affects the expression of STX8 mRNA

NCBI chr10:53,154,572...53,393,912
Ensembl chr10:53,153,523...53,429,541

G

syntaxin binding protein 1

affects expression

EXP

Clozapine affects the expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058

G

succinate-CoA ligase ADP-forming subunit beta

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of SUCLA2 protein

NCBI chr15:55,161,894...55,215,031
Ensembl chr15:55,161,868...55,215,029

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

ISO

Clozapine results in decreased expression of SUCLG1 protein

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

SPT3 homolog, SAGA and STAGA complex component

increases expression

EXP

Clozapine results in increased expression of SUPT3H mRNA

NCBI chr 9:23,375,889...23,704,229
Ensembl chr 9:23,376,136...23,704,466

G

synapsin II

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA

PMID:15860345 PMID:17266109

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

ISO

Clozapine results in decreased expression of SYNCRIP protein

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

synaptotagmin 11

increases expression

EXP

Clozapine results in increased expression of SYT11 mRNA

NCBI chr 2:176,503,845...176,530,354
Ensembl chr 2:176,503,845...176,529,775

G

synaptotagmin 2

increases expression

ISO

Clozapine results in increased expression of SYT2 mRNA

NCBI chr13:48,639,634...48,749,814
Ensembl chr13:48,639,934...48,749,812

G

synaptotagmin 4

increases expression

EXP

Clozapine results in increased expression of SYT4 mRNA

NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815

G

synaptotagmin 5

decreases expression

EXP

Clozapine results in decreased expression of SYT5 mRNA

NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:78,320,034...78,327,746

G

tachykinin, precursor 1

decreases expression

ISO
EXP

Clozapine results in decreased expression of TAC1 mRNA

PMID:10974607 PMID:17266109

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

transgelin

decreases expression

ISO

Clozapine results in decreased expression of TAGLN mRNA

PMID:15342952 PMID:17175557

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

transgelin 2

decreases expression

ISO

Clozapine results in decreased expression of TAGLN2 protein

NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330

G

TAO kinase 2

increases expression

ISO

Clozapine results in increased expression of TAOK2 protein

NCBI chr 1:190,906,236...190,925,359
Ensembl chr 1:190,906,239...190,925,140

G

TatD DNase domain containing 1

increases expression

ISO

Clozapine results in increased expression of TATDN1 mRNA

NCBI chr 7:92,339,452...92,370,445
Ensembl chr 7:92,330,554...92,370,400

G

TBC1 domain family, member 15

increases expression

ISO

Clozapine results in increased expression of TBC1D15 protein

NCBI chr 7:52,690,770...52,746,309
Ensembl chr 7:52,690,770...52,746,303

G

TBC1 domain family member 8B

increases expression

ISO

Clozapine results in increased expression of TBC1D8B protein

NCBI chr X:108,107,796...108,195,744
Ensembl chr X:108,107,769...108,195,732

G

tubulin folding cofactor B

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TBCB protein

NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:94,605,101...94,610,949

G

transducin (beta)-like 3

increases expression

ISO

Clozapine results in increased expression of TBL3 protein

NCBI chr10:14,230,660...14,235,873
Ensembl chr10:14,230,661...14,235,873

G

TRPM8 channel-associated factor 1

decreases expression

ISO

Clozapine results in decreased expression of TCAF1 protein

NCBI chr 4:72,589,710...72,639,304
Ensembl chr 4:72,589,710...72,639,475

G

testin LIM domain protein

decreases expression

ISO

Clozapine results in decreased expression of TES protein

NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:46,331,257...46,369,780

G

trans-golgi network protein 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TGOLN2 protein

NCBI chr 4:106,221,503...106,229,360
Ensembl chr 4:106,221,509...106,229,262

G

tyrosine hydroxylase

decreases activity
multiple interactions
increases expression
decreases expression
increases activity

EXP
ISO

Clozapine results in decreased activity of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
Clozapine results in increased expression of TH protein
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine

PMID:12645084 PMID:15983997 PMID:16402076 PMID:16415089 PMID:17028028

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

thyroid hormone receptor alpha

decreases expression
increases expression

EXP

Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor associated protein 3

decreases expression

ISO

Clozapine results in decreased expression of THRAP3 protein

NCBI chr 5:143,729,821...143,772,105
Ensembl chr 5:143,730,596...143,771,983

G

thyroid hormone receptor beta

decreases expression

EXP

Clozapine results in decreased expression of THRB mRNA alternative form

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

talin 2

decreases expression

ISO

Clozapine results in decreased expression of TLN2 protein

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361

G

transmembrane 9 superfamily member 2

decreases expression

ISO

Clozapine results in decreased expression of TM9SF2 protein

NCBI chr15:105,606,082...105,660,715
Ensembl chr15:105,606,118...105,660,714

G

transmembrane p24 trafficking protein 10

decreases expression

ISO

Clozapine results in decreased expression of TMED10 protein

NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:110,722,889...110,757,777

G

transmembrane protein 109

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of TMEM109 protein

NCBI chr 1:216,944,516...216,955,091
Ensembl chr 1:216,944,519...216,955,138

G

thymopoietin

decreases expression

ISO

Clozapine results in decreased expression of TMPO protein

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937

G

tumor necrosis factor

affects response to substance
increases secretion
multiple interactions
increases expression

ISO
EXP

TNF protein affects the susceptibility to Clozapine
Clozapine results in increased secretion of TNF protein
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein]
Clozapine results in increased expression of TNF protein

PMID:20521320 PMID:24709159 PMID:34935985

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 15

decreases expression

ISO

Clozapine results in decreased expression of TNFSF15 mRNA

NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:82,150,376...82,171,882

G

TRAF2 and NCK interacting kinase

decreases expression

ISO

Clozapine results in decreased expression of TNIK mRNA

NCBI chr 2:113,112,937...113,511,341
Ensembl chr 2:113,112,938...113,511,339

G

DNA topoisomerase I mitochondrial

increases expression

ISO

Clozapine results in increased expression of TOP1MT protein

NCBI chr 7:109,223,269...109,248,855
Ensembl chr 7:109,139,527...109,246,799

G

tumor protein p53

increases expression
multiple interactions

ISO

Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

triosephosphate isomerase 1

increases expression

EXP

Clozapine results in increased expression of TPI1 mRNA

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

tropomyosin 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TPM2 protein

NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726

G

tropomyosin 3

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TPM3 protein

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

tropomyosin 4

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TPM4 protein

NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494

G

translocated promoter region, nuclear basket protein

decreases expression

ISO

Clozapine results in decreased expression of TPR protein

NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602

G

transformer 2 beta

decreases expression

ISO

Clozapine results in decreased expression of TRA2B protein

NCBI chr11:92,293,403...92,311,651
Ensembl chr11:92,293,410...92,311,781

G

tripartite motif-containing 2

decreases expression

ISO

Clozapine results in decreased expression of TRIM2 mRNA

NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:171,798,660...171,913,468

G

tripartite motif-containing 28

decreases expression

ISO

Clozapine results in decreased expression of TRIM28 protein

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tetraspanin 3

decreases expression
increases expression

ISO

Clozapine results in decreased expression of TSPAN3 protein
Clozapine results in increased expression of TSPAN3 protein

PMID:34122009 PMID:36482696

NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844

G

tau tubulin kinase 1

increases expression

ISO

Clozapine results in increased expression of TTBK1 protein

NCBI chr 9:21,990,973...22,035,961
Ensembl chr 9:21,990,973...22,035,961

G

transthyretin

decreases expression
increases expression

ISO
EXP

Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein

PMID:15927202 PMID:17266109

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

tweety family member 2

increases expression

ISO

Clozapine results in increased expression of TTYH2 protein

NCBI chr10:100,208,129...100,252,505
Ensembl chr10:100,207,860...100,253,521

G

tubulin, alpha-like 3

increases expression

ISO

Clozapine results in increased expression of TUBAL3 protein

NCBI chr17:71,233,194...71,245,297
Ensembl chr17:71,232,851...71,245,337

G

tubulin, beta 4B class IVb

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of TUBB4B protein

NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719

G

tubulin, beta 5 class I

increases expression

ISO

Clozapine results in increased expression of TUBB protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

tubulin, beta 6 class V

decreases expression

ISO

Clozapine results in decreased expression of TUBB6 protein

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

increases expression

ISO

Clozapine results in increased expression of UAP1L1 protein

NCBI chr 3:28,570,854...28,579,766
Ensembl chr 3:28,573,358...28,578,630

G

ubiquitin-like modifier activating enzyme 2

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in increased expression of UBA2 protein

NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901

G

ubiquitin A-52 residue ribosomal protein fusion product 1

increases expression

ISO

Clozapine results in increased expression of UBA52 mRNA

NCBI chr16:18,952,583...18,954,780

G

ubiquitin-conjugating enzyme E2R 2

affects expression

ISO

Clozapine affects the expression of UBE2R2 mRNA

NCBI chr 5:61,082,552...61,141,099
Ensembl chr 5:61,082,552...61,141,452

G

upstream binding transcription factor

decreases expression

ISO

Clozapine results in decreased expression of UBTF protein

NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,758,346...87,773,088

G

UDP glucuronosyltransferase family 1 member A1

increases expression

ISO

Clozapine results in increased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases glucuronidation

ISO

UGT1A4 protein SNP results in increased glucuronidation of Clozapine

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

unc-13 homolog A

decreases expression

EXP

Clozapine results in decreased expression of UNC13A mRNA

NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899

G

unc-45 myosin chaperone B

increases expression

ISO

Clozapine results in increased expression of UNC45B protein

NCBI chr10:68,343,011...68,370,683
Ensembl chr10:68,343,014...68,370,980

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

ISO

Clozapine affects the expression of UQCR11 mRNA

NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047

G

ubiquitin specific peptidase 34

increases expression

ISO

Clozapine results in increased expression of USP34 protein

NCBI chr14:101,487,110...101,677,519
Ensembl chr14:101,487,153...101,678,632

G

ubiquitin specific peptidase 5

increases expression

ISO

Clozapine results in increased expression of USP5 protein

NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:159,305,938...159,320,956

G

UTP18 small subunit processome component

increases expression

ISO

Clozapine results in increased expression of UTP18 protein

NCBI chr10:79,308,785...79,336,241
Ensembl chr10:79,308,787...79,336,197

G

vesicle-associated membrane protein 1

increases expression

EXP

Clozapine results in increased expression of VAMP1 mRNA

NCBI chr 4:159,698,894...159,705,582
Ensembl chr 4:159,698,629...159,713,608

G

vesicle-associated membrane protein 2

increases expression

EXP

Clozapine results in increased expression of VAMP2 mRNA

NCBI chr10:54,292,423...54,296,657
Ensembl chr10:54,292,806...54,296,654

G

VAMP associated protein A

increases expression

ISO

Clozapine results in increased expression of VAPA protein

NCBI chr 9:112,624,791...112,654,731
Ensembl chr 9:112,624,794...112,654,731

G

VAMP associated protein B and C

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of VAPB protein

NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619

G

vinculin

increases expression

ISO

Clozapine results in increased expression of VCL protein

NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163

G

voltage-dependent anion channel 1

decreases expression

ISO

Clozapine results in decreased expression of VDAC1 protein

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

visinin-like 1

decreases expression

EXP

Clozapine results in decreased expression of VSNL1 mRNA

NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:39,757,722...39,878,556

G

tryptophanyl-tRNA synthetase 1

multiple interactions

ISO

[Cuprizone co-treated with Clozapine] results in decreased expression of WARS1 protein

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WW domain binding protein 1-like

decreases expression

ISO

Clozapine results in decreased expression of WBP1L mRNA

NCBI chr 1:255,413,701...255,470,026
Ensembl chr 1:255,413,524...255,470,026

G

WD repeat domain 12

decreases expression

ISO

Clozapine results in decreased expression of WDR12 protein

NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:68,969,547...68,996,811

G

WD repeat domain, phosphoinositide interacting 1

increases expression

ISO

Clozapine results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

ISO

Clozapine results in decreased expression of YWHAB mRNA

NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

increases expression

ISO

Clozapine results in increased expression of YWHAQ protein

NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875

G

zinc finger CCCH-type containing, antiviral 1

decreases expression

ISO

Clozapine results in decreased expression of ZC3HAV1 protein

NCBI chr 4:67,979,055...68,029,353
Ensembl chr 4:67,979,055...68,029,353

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

darifenacin binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions

ISO

darifenacin binds to and results in decreased activity of CHRM3 protein

PMID:11488427 PMID:15140916

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

darifenacin results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

dibenzheptropine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

ISO

Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

ISO

Dimenhydrinate results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

solute carrier family 22 member 2

multiple interactions

ISO

Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

diphenhydramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy related 5

affects response to substance

ISO

ATG5 protein affects the susceptibility to Diphenhydramine

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

butyrylcholinesterase

multiple interactions
decreases activity

ISO

Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

bone morphogenetic protein 6

decreases expression

ISO

Diphenhydramine results in decreased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

epiregulin

decreases expression

ISO

Diphenhydramine results in decreased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

coagulation factor III, tissue factor

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

G protein subunit alpha i1

increases response to substance

ISO

GNAI1 results in increased susceptibility to Diphenhydramine

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

G protein subunit alpha i2

increases response to substance

ISO

GNAI2 results in increased susceptibility to Diphenhydramine

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

histamine receptor H 1

multiple interactions

ISO
EXP

Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin

PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 More...

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

interleukin 1 beta

increases expression
decreases expression

ISO

Diphenhydramine results in increased expression of IL1B mRNA
Diphenhydramine results in decreased expression of IL1B mRNA

PMID:28138970 PMID:32816093

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

decreases expression

ISO

Diphenhydramine results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 6

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen-activated protein kinase 8

increases activity

ISO

Diphenhydramine results in increased activity of MAPK8

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

[Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

phospholipase A2 group 4A

multiple interactions

ISO

Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Diphenhydramine results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 22 member 1

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:16263091 PMID:21599003

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions

ISO

Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 5

multiple interactions

ISO

Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 7 member 11

decreases expression

ISO

Diphenhydramine results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Diphenhydramine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

methoctramine tetrahydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 1

multiple interactions

ISO

methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 4

multiple interactions

ISO

methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

cholinergic receptor, muscarinic 5

multiple interactions

ISO

methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

mitogen activated protein kinase 1

increases phosphorylation

EXP

methoctramine analog results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

EXP

methoctramine analog results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 1

multiple interactions

EXP

methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

multiple interactions

EXP

methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

ornithine decarboxylase 1

decreases activity

ISO

methoctramine analog results in decreased activity of ODC1 protein; methoctramine results in decreased activity of ODC1 protein

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

spermidine/spermine N1-acetyl transferase 1

increases activity

ISO

methoctramine analog results in increased activity of SAT1 protein; methoctramine results in increased activity of SAT1 protein

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

tumor protein p53

increases expression

EXP

methoctramine analog results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

methixene results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

Bcl2-like 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions

ISO

NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 2

decreases secretion

ISO

NSC 23766 results in decreased secretion of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

decreases secretion

ISO

NSC 23766 results in decreased secretion of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

decreases secretion

ISO

NSC 23766 results in decreased secretion of CCL4 protein

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

cellular communication network factor 2

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

Cd47 molecule

multiple interactions

ISO

NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]

NCBI chr11:64,374,816...64,438,763
Ensembl chr11:64,377,926...64,438,272

G

cell division cycle 42

multiple interactions

ISO

NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627

G

DNA-damage inducible transcript 3

affects expression

ISO

NSC 23766 affects the expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

Fms related receptor tyrosine kinase 3

affects response to substance

ISO

FLT3 protein affects the susceptibility to NSC 23766

NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581

G

glutathione peroxidase 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

H2A.X variant histone

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hepatocyte growth factor

decreases secretion

ISO

NSC 23766 results in decreased secretion of HGF protein

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

heme oxygenase 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

intercellular adhesion molecule 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]

PMID:19632255 PMID:22166487

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 1 beta

multiple interactions

ISO

NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]

PMID:21511011 PMID:31018152

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

mitogen-activated protein kinase kinase kinase 11

multiple interactions

ISO

NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein]

NCBI chr 1:212,404,685...212,417,986
Ensembl chr 1:212,403,680...212,417,983

G

mitofusin 2

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA]

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

matrix metallopeptidase 1

multiple interactions
decreases secretion

ISO

NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]
NSC 23766 results in decreased secretion of MMP1 protein

PMID:18625914 PMID:36009428

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 3

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

myeloperoxidase

multiple interactions

ISO

NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nucleophosmin 1

affects response to substance

ISO

NPM1 protein affects the susceptibility to NSC 23766

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

natriuretic peptide A

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [sodium arsenite results in increased expression of PECAM1 protein]

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

PPARG coactivator 1 alpha

multiple interactions

ISO

NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

Rac family small GTPase 1

multiple interactions
decreases activity

ISO

NSC 23766 inhibits the reaction [sodium arsenite results in increased activity of RAC1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]
NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of RAC1 protein]
NSC 23766 results in decreased activity of RAC1 protein

PMID:19349368 PMID:21511011 PMID:22166487 PMID:28710503 PMID:31018152

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Rac family small GTPase 2

multiple interactions

ISO

NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased activity of RAC2 protein]

NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267

G

ras homolog family member B

multiple interactions

ISO

NSC 23766 inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB mRNA]

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

serpin family E member 1

decreases secretion

ISO

NSC 23766 results in decreased secretion of SERPINE1 protein

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

signal-regulatory protein alpha

multiple interactions

ISO

NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; NSC 23766 inhibits the reaction [[CD47 protein binds to SIRPA protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]

NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:137,273,042...137,311,279

G

tumor necrosis factor

multiple interactions
decreases secretion

ISO

NSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
NSC 23766 results in decreased secretion of TNF protein

PMID:21511011 PMID:36009428

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vascular cell adhesion molecule 1

multiple interactions

ISO

NSC 23766 inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

affects phosphorylation

ISO

olanzapine affects the phosphorylation of A1BG protein

NCBI chr 7:94,383,333...94,387,922
Ensembl chr 7:94,383,333...94,387,496

G

alpha-2-macroglobulin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of A2M protein

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

olanzapine results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

decreases activity
multiple interactions

ISO
EXP

olanzapine results in decreased activity of ABCB1 protein
[[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which affects the abundance of Olanzapine; [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which results in increased uptake of Olanzapine; [ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] results in increased abundance of and results in decreased uptake of Olanzapine

PMID:16810505 PMID:34610281

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

multiple interactions

EXP

[[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which affects the abundance of Olanzapine; [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which results in increased uptake of Olanzapine; [ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] results in increased abundance of and results in decreased uptake of Olanzapine

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily G member 2

multiple interactions

ISO

olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

acetyl-CoA carboxylase alpha

decreases expression
multiple interactions

ISO

Olanzapine results in decreased expression of ACACA mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA oxidase 1

multiple interactions

EXP

[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

ADCYAP receptor type I

affects expression

ISO

olanzapine affects the expression of ADCYAP1R1 mRNA

NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:85,924,100...85,972,973

G

adiponectin, C1Q and collagen domain containing

increases expression
decreases expression
multiple interactions

ISO

olanzapine results in increased expression of ADIPOQ mRNA
Olanzapine results in decreased expression of ADIPOQ protein
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]

PMID:17651982 PMID:32652086

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

afamin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of AFM protein

NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,815,194...17,848,039

G

agouti related neuropeptide

increases expression
multiple interactions

EXP
ISO

olanzapine results in increased expression of AGRP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]

PMID:21695181 PMID:32652086

NCBI chr19:50,357,899...50,396,758
Ensembl chr19:50,357,905...50,358,698

G

AKT serine/threonine kinase 1

increases expression
decreases expression
multiple interactions
increases response to substance
increases phosphorylation

ISO

Olanzapine results in increased expression of AKT1 mRNA; Olanzapine results in increased expression of AKT1 protein
Olanzapine results in decreased expression of AKT1 mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
AKT1 gene SNP results in increased susceptibility to olanzapine
olanzapine results in increased phosphorylation of AKT1 protein

PMID:19440698 PMID:21187413 PMID:32652086

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

apolipoprotein A1

increases phosphorylation

ISO

olanzapine results in increased phosphorylation of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein A4

affects phosphorylation

ISO

olanzapine affects the phosphorylation of APOA4 protein

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein B

increases phosphorylation

ISO

olanzapine results in increased phosphorylation of APOB protein

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein C3

affects response to substance

EXP

APOC3 gene polymorphism affects the susceptibility to olanzapine

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

apolipoprotein H

affects phosphorylation

ISO

olanzapine affects the phosphorylation of APOH protein

NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127

G

amyloid beta precursor protein

multiple interactions

EXP

olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]; olanzapine inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 4

affects response to substance
increases response to substance

ISO

AQP4 gene polymorphism affects the susceptibility to olanzapine
AQP4 protein results in increased susceptibility to olanzapine

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

olanzapine results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
increases expression

EXP

olanzapine inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]
olanzapine results in increased expression of BCL2 mRNA; olanzapine results in increased expression of BCL2 protein

PMID:15126120 PMID:15276877

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

increases expression

EXP
ISO

olanzapine results in increased expression of BDNF mRNA; olanzapine results in increased expression of BDNF protein
Olanzapine results in increased expression of BDNF mRNA; Olanzapine results in increased expression of BDNF protein

PMID:12478621 PMID:17442489 PMID:29182611

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

BCL2-interacting killer

increases expression

ISO

olanzapine results in increased expression of BIK mRNA

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

complement C3

affects phosphorylation

ISO

olanzapine affects the phosphorylation of C3 protein

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

complement C4A (Rodgers blood group)

decreases phosphorylation

ISO

olanzapine results in decreased phosphorylation of C4A protein

NCBI chr20:4,010,306...4,024,707

G

complement C4B

affects phosphorylation

ISO

olanzapine affects the phosphorylation of C4B protein

NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289

G

complement C5

affects phosphorylation

ISO

olanzapine affects the phosphorylation of C5 protein

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

complement C6

affects phosphorylation

ISO

olanzapine affects the phosphorylation of C6 protein

NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120

G

complement C9

affects phosphorylation

ISO

olanzapine affects the phosphorylation of C9 protein

NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:57,300,427...57,348,752

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

EXP

olanzapine results in decreased expression of and results in decreased phosphorylation of CAMK2A protein

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

catalase

multiple interactions

EXP

olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

complement factor B

affects phosphorylation

ISO

olanzapine affects the phosphorylation of CFB protein

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

complement factor H

decreases phosphorylation

ISO

olanzapine results in decreased phosphorylation of CFH protein

NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532

G

cholinergic receptor, muscarinic 1

affects binding

ISO

olanzapine binds to CHRM1 protein

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

clusterin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of CLU protein

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

collagen type I alpha 1 chain

decreases phosphorylation

ISO

olanzapine results in decreased phosphorylation of COL1A1 protein

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

catechol-O-methyltransferase

increases expression

EXP

olanzapine results in increased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

ceruloplasmin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of CP protein

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

carnitine palmitoyltransferase 2

multiple interactions

EXP

[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of CPT2 mRNA; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

cAMP responsive element binding protein 1

multiple interactions

EXP

[Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

citrate synthase

increases activity
multiple interactions

EXP

Olanzapine results in increased activity of CS protein
[Olanzapine co-treated with Fluoxetine] results in increased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

catenin beta 1

decreases expression
increases expression
multiple interactions

ISO

olanzapine results in decreased expression of CTNNB1 mRNA
Olanzapine results in increased expression of CTNNB1 mRNA
Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]

PMID:18797397 PMID:31563592

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
multiple interactions

ISO

CYP1A2 protein affects the metabolism of olanzapine
Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]

PMID:15545309 PMID:15883149

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

Olanzapine results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DAB adaptor protein 1

decreases expression

EXP

olanzapine results in decreased expression of DAB1 protein

NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584

G

doublecortin-like kinase 1

increases expression

ISO

olanzapine results in increased expression of DCLK1 mRNA

NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090

G

dopamine receptor D1

affects binding

ISO

olanzapine binds to DRD1 protein

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

increases response to substance
affects binding
multiple interactions
decreases activity
affects activity

ISO
EXP

DRD2 gene SNP results in increased susceptibility to olanzapine; DRD2 intron SNP results in increased susceptibility to olanzapine
olanzapine binds to DRD2 protein
olanzapine promotes the reaction [Dopamine binds to DRD2 protein]
olanzapine results in decreased activity of DRD2 protein
olanzapine affects the activity of DRD2 protein

PMID:10482380 PMID:10831489 PMID:11198054 PMID:15716360 PMID:20361897 More...

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

multiple interactions

ISO

DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

coagulation factor II, thrombin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

fatty acid binding protein 1

increases expression

ISO

Olanzapine results in increased expression of FABP1 mRNA

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

fatty acid synthase

increases expression

ISO

olanzapine results in increased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibroblast growth factor 2

multiple interactions

EXP

[Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibronectin 1

affects phosphorylation

ISO

olanzapine affects the phosphorylation of FN1 protein

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

[Fluoxetine co-treated with olanzapine] results in decreased expression of FOS protein

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

EXP

olanzapine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein]

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

glutamate decarboxylase 1

decreases expression

EXP

olanzapine results in decreased expression of GAD1 mRNA; olanzapine results in decreased expression of GAD1 protein

PMID:14519413 PMID:19359144

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

glutamate decarboxylase 2

decreases expression

EXP

olanzapine results in decreased expression of GAD2 protein

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

GC, vitamin D binding protein

affects phosphorylation

ISO

olanzapine affects the phosphorylation of GC protein

NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673

G

glutamate-cysteine ligase, catalytic subunit

increases expression

ISO

Olanzapine results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glial fibrillary acidic protein

multiple interactions
increases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

ghrelin and obestatin prepropeptide

multiple interactions
increases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein]

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

growth hormone secretagogue receptor

increases expression
multiple interactions

ISO

Olanzapine results in increased expression of GHSR mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]

NCBI chr 2:112,196,158...112,201,666
Ensembl chr 2:112,196,767...112,201,181

G

glutamic--pyruvic transaminase

multiple interactions
increases expression

ISO

Dietary Fats promotes the reaction [Olanzapine results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutamate ionotropic receptor AMPA type subunit 2

increases expression

EXP

olanzapine results in increased expression of GRIA2 mRNA

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

EXP

olanzapine results in increased expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:125,103,782...125,369,679

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions
decreases expression

ISO

olanzapine results in increased phosphorylation of GSK3B protein
Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Olanzapine results in decreased expression of GSK3B mRNA

PMID:19440698 PMID:31563592

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
decreases expression
multiple interactions

ISO
EXP

olanzapine results in increased expression of HMGCR mRNA
olanzapine results in decreased expression of HMGCR mRNA
1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]

PMID:17052361 PMID:23226405

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

olanzapine results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

heme oxygenase 1

increases expression

ISO

Olanzapine results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hemopexin

affects phosphorylation

ISO

olanzapine affects the phosphorylation of HPX protein

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

histidine-rich glycoprotein

affects phosphorylation

ISO

olanzapine affects the phosphorylation of HRG protein

NCBI chr11:91,559,087...91,573,982
Ensembl chr11:91,559,091...91,573,982

G

histamine receptor H 1

affects binding
multiple interactions

ISO

olanzapine binds to HRH1 protein
HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]

PMID:16983399 PMID:20021991 PMID:24389121

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

5-hydroxytryptamine receptor 2A

multiple interactions
affects binding
decreases activity

ISO
EXP

olanzapine binds to and results in decreased activity of HTR2A protein
olanzapine binds to HTR2A protein
olanzapine results in decreased activity of HTR2A protein
[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; olanzapine binds to and results in decreased activity of HTR2A protein

PMID:16983399 PMID:18976543 PMID:19304867 PMID:20521326 PMID:24389121

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

5-hydroxytryptamine receptor 2C

increases response to substance
affects binding
affects response to substance

ISO

HTR2C gene polymorphism results in increased susceptibility to olanzapine
olanzapine binds to HTR2C protein
HTR2C gene polymorphism affects the susceptibility to Olanzapine; HTR2C gene SNP affects the susceptibility to Olanzapine; HTR2C protein affects the susceptibility to Olanzapine

PMID:15666332 PMID:16983399 PMID:19142110 PMID:19434072 PMID:24389121

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

5-hydroxytryptamine receptor 6

affects binding

ISO

olanzapine binds to HTR6 protein

NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147

G

interleukin 10

increases expression
decreases expression
multiple interactions

ISO

Olanzapine results in increased expression of IL10 mRNA
Olanzapine results in decreased expression of IL10 protein
Lithium inhibits the reaction [Olanzapine results in decreased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions
increases expression

ISO

Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B protein]
Olanzapine results in increased expression of IL1B mRNA; Olanzapine results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Olanzapine results in increased expression of IL6 mRNA; Olanzapine results in increased expression of IL6 protein

PMID:30695037 PMID:32652086

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 2

increases secretion
increases expression

ISO

olanzapine results in increased secretion of INS protein
olanzapine results in increased expression of INS protein

PMID:11769361 PMID:11927762 PMID:16601995 PMID:19512971

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

inter-alpha-trypsin inhibitor heavy chain 2

affects phosphorylation

ISO

olanzapine affects the phosphorylation of ITIH2 protein

NCBI chr17:73,285,281...73,321,555
Ensembl chr17:73,285,270...73,321,547

G

inter-alpha-trypsin inhibitor heavy chain 4

affects phosphorylation

ISO

olanzapine affects the phosphorylation of ITIH4 protein

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160

G

Janus kinase 2

multiple interactions
increases activity

EXP

[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein
olanzapine results in increased activity of JAK2 protein

PMID:18976543 PMID:19304867

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

potassium voltage-gated channel subfamily A member 1

increases expression

ISO

olanzapine results in increased expression of KCNA1 mRNA

NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

decreases expression

ISO

olanzapine results in decreased expression of KCNAB1 mRNA

NCBI chr 2:151,446,975...151,913,636
Ensembl chr 2:151,446,947...151,913,636

G

potassium voltage-gated channel subfamily H member 2

decreases activity
multiple interactions

ISO

olanzapine results in decreased activity of KCNH2 protein
olanzapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:16494862 PMID:21158687

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel interacting protein 3

decreases expression

ISO

olanzapine results in decreased expression of KCNIP3 mRNA; olanzapine results in decreased expression of KCNIP3 protein

NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:135,132,119...135,196,216

G

kinesin light chain 1

decreases expression

ISO

olanzapine results in decreased expression of KLC1 mRNA

NCBI chr 6:136,644,592...136,690,399
Ensembl chr 6:136,644,307...136,689,760

G

kininogen 1

affects phosphorylation

ISO

Olanzapine affects the phosphorylation of KNG1 protein

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148

G

low density lipoprotein receptor

increases expression
multiple interactions

ISO

olanzapine results in increased expression of LDLR mRNA
olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]

PMID:17052361 PMID:17651982

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

leptin

increases expression
multiple interactions

ISO

olanzapine results in increased expression of LEP protein
Olanzapine results in increased expression of LEP protein
capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein]

PMID:11927762 PMID:19512971 PMID:32652086

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

mal, T-cell differentiation protein

decreases expression

ISO

olanzapine results in decreased expression of MAL mRNA

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

monoamine oxidase A

increases expression

EXP

olanzapine results in increased expression of MAOA mRNA

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

increases expression

EXP

olanzapine results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 2

increases expression

EXP

olanzapine results in increased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

marker of proliferation Ki-67

increases expression

EXP

Olanzapine results in increased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

methylenetetrahydrofolate reductase

affects response to substance

ISO

MTHFR gene polymorphism affects the susceptibility to olanzapine; MTHFR protein affects the susceptibility to olanzapine

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

neurocan

decreases expression

ISO

olanzapine results in decreased expression of NCAN mRNA

NCBI chr16:19,335,907...19,362,371
Ensembl chr16:19,335,907...19,362,371

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

ISO

olanzapine results in decreased expression of NEDD4 mRNA; olanzapine results in decreased expression of NEDD4 protein

NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633

G

NFE2 like bZIP transcription factor 2

decreases expression

ISO

Olanzapine results in decreased expression of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

neuroplastin

increases expression

ISO

olanzapine results in increased expression of NPTN mRNA

NCBI chr 8:67,892,678...67,959,231
Ensembl chr 8:67,892,702...67,959,236

G

neuropeptide Y

decreases expression
increases expression
multiple interactions

EXP
ISO

olanzapine results in decreased expression of NPY mRNA
Olanzapine results in increased expression of NPY mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]
olanzapine results in increased expression of NPY protein

PMID:16516965 PMID:21695181 PMID:32652086

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

NUMB-like, endocytic adaptor protein

decreases expression

ISO

olanzapine results in decreased expression of NUMBL mRNA

NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424

G

phosphodiesterase 1A

increases expression

EXP

olanzapine results in increased expression of PDE1A mRNA

NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212

G

phosphodiesterase 8B

increases expression

EXP

olanzapine results in increased expression of PDE8B mRNA

NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions
decreases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

placenta associated 8

affects phosphorylation

ISO

olanzapine affects the phosphorylation of C15 protein

NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572

G

proteolipid protein 1

decreases expression

ISO

olanzapine results in decreased expression of PLP1 mRNA

NCBI chr X:104,933,921...104,993,317
Ensembl chr X:104,975,780...104,993,314

G

patatin-like phospholipase domain containing 2

affects expression

EXP

olanzapine affects the expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

proopiomelanocortin

decreases expression
multiple interactions

EXP
ISO

olanzapine results in decreased expression of POMC protein
Olanzapine results in decreased expression of POMC mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]

PMID:21695181 PMID:32652086

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

olanzapine results in increased expression of PPARG protein alternative form

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

decreases expression
multiple interactions

EXP

olanzapine results in decreased expression of PPARGC1A mRNA
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein kinase AMP-activated non-catalytic subunit gamma 2

increases expression
multiple interactions

ISO

Olanzapine results in increased expression of PRKAG2 mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]

NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,744,588...10,985,939

G

prolactin

multiple interactions
increases expression
increases secretion

ISO
EXP

[olanzapine co-treated with Fluoxetine] results in increased expression of PRL protein
Olanzapine results in increased expression of PRL protein
Bromocriptine inhibits the reaction [Olanzapine results in increased expression of PRL protein]
olanzapine results in increased secretion of PRL protein
olanzapine results in increased expression of PRL protein

PMID:9090331 PMID:9265911 PMID:9376336 PMID:10831029 PMID:11048906 More...

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prolactin receptor

increases expression

EXP

Olanzapine results in increased expression of PRLR mRNA; Olanzapine results in increased expression of PRLR protein

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

proline-rich coiled-coil 2A

decreases expression

ISO

olanzapine results in decreased expression of PRRC2A mRNA

NCBI chr20:3,660,981...3,686,715
Ensembl chr20:3,663,400...3,678,778

G

Rap guanine nucleotide exchange factor 4

decreases expression

ISO

olanzapine results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

reelin

increases expression

EXP

olanzapine results in increased expression of RELN mRNA; olanzapine results in increased expression of RELN protein

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

regulator of G-protein signaling 7

multiple interactions
increases expression

EXP

[[Olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 protein]; Olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; Olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]
olanzapine results in increased expression of RGS7 mRNA; olanzapine results in increased expression of RGS7 protein

PMID:18976543 PMID:19304867

NCBI chr13:89,511,492...89,941,082
Ensembl chr13:89,511,150...89,940,987

G

reticulon 4

decreases expression

ISO

olanzapine results in decreased expression of RTN4 mRNA

NCBI chr14:107,651,001...107,698,610
Ensembl chr14:107,650,732...107,698,611

G

S100 calcium binding protein A9

decreases expression

ISO

olanzapine results in decreased expression of S100A9 mRNA

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

sterol-C5-desaturase

increases expression

ISO

olanzapine results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

serpin family A member 3N

increases phosphorylation

ISO

Olanzapine results in increased phosphorylation of SERPINA3 protein

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family G member 1

affects phosphorylation

ISO

olanzapine affects the phosphorylation of SERPING1 protein

NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717

G

serpin family I member 1

decreases expression

ISO

olanzapine results in decreased expression of SERPINI1 mRNA

NCBI chr 2:162,645,209...162,731,737
Ensembl chr 2:162,645,350...162,731,740

G

sex hormone binding globulin

decreases expression

ISO

olanzapine results in decreased expression of SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

solute carrier family 22 member 2

multiple interactions

ISO

olanzapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

decreases expression
multiple interactions

ISO

Olanzapine results in decreased expression of SLC22A5 mRNA; Olanzapine results in decreased expression of SLC22A5 protein
Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 27 member 2

increases expression

ISO

Olanzapine results in increased expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 27 member 5

increases expression

ISO

Olanzapine results in increased expression of SLC27A5 mRNA

NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358

G

solute carrier family 2 member 4

increases expression

ISO

olanzapine results in increased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 7 member 11

decreases expression

ISO

Olanzapine results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

synaptosome associated protein 25

affects response to substance

ISO

SNAP25 gene SNP affects the susceptibility to olanzapine

NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448

G

superoxide dismutase 1

multiple interactions
decreases activity
increases expression

EXP
ISO

olanzapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; olanzapine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]
Olanzapine results in decreased activity of SOD1 protein
Dietary Fats promotes the reaction [Olanzapine results in decreased activity of SOD1 protein]
olanzapine results in increased expression of SOD1 mRNA

PMID:12752374 PMID:12868070 PMID:16564057 PMID:37019375

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

ISO

olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]; olanzapine results in increased activity of and results in increased expression of SREBF1 protein
olanzapine results in increased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sterol regulatory element binding transcription factor 2

multiple interactions

ISO
EXP

olanzapine results in increased cleavage of and results in increased activity of SREBF2 protein
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA

PMID:17052361 PMID:23226405

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

signal transducer and activator of transcription 3

multiple interactions

EXP

olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

synaptophysin-like 1

decreases expression

ISO

Olanzapine results in decreased expression of SYPL1 mRNA

NCBI chr 6:55,292,555...55,311,519
Ensembl chr 6:55,292,567...55,314,714

G

tyrosine hydroxylase

multiple interactions

EXP

olanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

multiple interactions
increases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Dietary Fats promotes the reaction [Olanzapine results in increased expression of TNF protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein]
Olanzapine results in increased expression of TNF mRNA; Olanzapine results in increased expression of TNF protein

PMID:30695037 PMID:32652086 PMID:37019375

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases expression

ISO

olanzapine results in increased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions
increases expression

ISO

capsazepine inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

transient receptor potential cation channel, subfamily V, member 3

multiple interactions
increases expression

ISO

Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA]

NCBI chr10:58,382,054...58,413,657
Ensembl chr10:58,382,054...58,411,800

G

transthyretin

increases expression

EXP

olanzapine results in increased expression of TTR mRNA

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

uncoupling protein 1

multiple interactions

EXP

[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of UCP1 mRNA

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

vasoactive intestinal peptide receptor 2

affects expression

ISO

olanzapine affects the expression of VIPR2 mRNA

NCBI chr 6:143,139,672...143,213,609
Ensembl chr 6:143,144,523...143,213,609

G

very low density lipoprotein receptor

increases expression

EXP

olanzapine results in increased expression of VLDLR protein

NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein like 1

affects expression

EXP

Orphenadrine affects the expression of A1BGL1 mRNA

NCBI chr 7:94,204,333...94,208,057
Ensembl chr 7:94,203,965...94,207,346

G

alpha-2-macroglobulin

affects expression

EXP

Orphenadrine affects the expression of A2M mRNA

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

ATP-binding cassette, sub-family B member 1B

affects expression

EXP

Orphenadrine affects the expression of ABCB1B mRNA

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily C member 2

multiple interactions

EXP

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

affects expression

EXP

Orphenadrine affects the expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily D member 2

affects expression

EXP

Orphenadrine affects the expression of ABCD2 mRNA

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202

G

actin binding LIM protein family, member 3

affects expression

EXP

Orphenadrine affects the expression of ABLIM3 mRNA

NCBI chr18:57,527,917...57,646,936
Ensembl chr18:57,527,917...57,646,710

G

angiotensin converting enzyme 2

affects expression

EXP

Orphenadrine affects the expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

alkaline ceramidase 3

affects expression

EXP

Orphenadrine affects the expression of ACER3 mRNA

NCBI chr 1:161,915,397...162,017,802
Ensembl chr 1:161,915,397...162,017,912

G

acyl-CoA synthetase long-chain family member 5

affects expression

EXP

Orphenadrine affects the expression of ACSL5 mRNA

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943

G

acyl-CoA synthetase medium-chain family member 3

affects expression

EXP

Orphenadrine affects the expression of ACSM3 mRNA

NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437

G

adhesion G protein-coupled receptor G2

affects expression

EXP

Orphenadrine affects the expression of ADGRG2 mRNA

NCBI chr X:38,106,067...38,231,286
Ensembl chr X:38,106,067...38,231,331

G

adhesion G protein-coupled receptor V1

affects expression

EXP

Orphenadrine affects the expression of ADGRV1 mRNA

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:13,067,150...13,647,372

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

EXP

Orphenadrine affects the expression of ADH4 mRNA

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

adenosine A1 receptor

affects expression

EXP

Orphenadrine affects the expression of ADORA1 mRNA

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190

G

adenosine A2a receptor

affects expression

EXP

Orphenadrine affects the expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adrenoceptor beta 2

affects expression

EXP

Orphenadrine affects the expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

ajuba LIM protein

affects expression

EXP

Orphenadrine affects the expression of JUB mRNA

NCBI chr15:31,989,796...32,000,042
Ensembl chr15:31,989,799...32,000,042

G

aldo-keto reductase family 7 member A3

affects expression

EXP

Orphenadrine affects the expression of AKR7A3 mRNA

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

aldehyde dehydrogenase 1 family, member A1

affects expression

EXP

Orphenadrine affects the expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

alkaline phosphatase, biomineralization associated

affects expression

EXP

Orphenadrine affects the expression of ALPL mRNA

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

ALS2 C-terminal like

affects expression

EXP

Orphenadrine affects the expression of ALS2CL mRNA

NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:119,743,248...119,762,843

G

adhesion molecule with Ig like domain 3

affects expression

EXP

Orphenadrine affects the expression of AMIGO3 mRNA

NCBI chr 8:117,620,499...117,622,025
Ensembl chr 8:117,616,629...117,626,577

G

angiomotin like 2

affects expression

EXP

Orphenadrine affects the expression of AMOTL2 mRNA

NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:112,181,863...112,198,030

G

angiopoietin-like 4

affects expression

EXP

Orphenadrine affects the expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

angiopoietin-like 6

affects expression

EXP

Orphenadrine affects the expression of ANGPTL6 mRNA

NCBI chr 8:27,689,804...27,696,172
Ensembl chr 8:27,689,806...27,696,111

G

ankyrin repeat domain 9

affects expression

EXP

Orphenadrine affects the expression of ANKRD9 mRNA

NCBI chr 6:135,827,355...135,830,002
Ensembl chr 6:135,775,869...135,837,893

G

anoctamin 1

affects expression

EXP

Orphenadrine affects the expression of ANO1 mRNA

NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:209,180,755...209,329,550

G

annexin A5

affects expression

EXP

Orphenadrine affects the expression of ANXA5 mRNA

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

amyloid beta precursor protein

affects expression

EXP

Orphenadrine affects the expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 9

affects expression

EXP

Orphenadrine affects the expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

Rho GTPase activating protein 10

affects expression

EXP

Orphenadrine affects the expression of ARHGAP10 mRNA

NCBI chr19:47,352,783...47,614,532
Ensembl chr19:47,352,276...47,614,531

G

Rho GTPase activating protein 22

affects expression

EXP

Orphenadrine affects the expression of ARHGAP22 mRNA

NCBI chr16:8,480,222...8,637,823
Ensembl chr16:8,479,956...8,637,822

G

Rho guanine nucleotide exchange factor 10

affects expression

EXP

Orphenadrine affects the expression of ARHGEF10 mRNA

NCBI chr16:81,349,429...81,440,439
Ensembl chr16:81,349,429...81,440,054

G

Rho guanine nucleotide exchange factor 15

affects expression

EXP

Orphenadrine affects the expression of ARHGEF15 mRNA

NCBI chr10:54,149,372...54,162,128
Ensembl chr10:54,149,372...54,162,128

G

armadillo repeat containing, X-linked 1

affects expression

EXP

Orphenadrine affects the expression of ARMCX1 mRNA

NCBI chr X:102,192,225...102,196,130
Ensembl chr X:102,192,015...102,199,115

G

arrestin domain containing 2

affects expression

EXP

Orphenadrine affects the expression of ARRDC2 mRNA

NCBI chr16:18,635,883...18,640,019
Ensembl chr16:18,635,883...18,640,158

G

activating transcription factor 3

affects expression

EXP

Orphenadrine affects the expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

ATPase plasma membrane Ca2+ transporting 2

affects expression

EXP

Orphenadrine affects the expression of ATP2B2 mRNA

NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:148,450,207...148,696,239

G

attractin like 1

affects expression

EXP

Orphenadrine affects the expression of ATRNL1 mRNA

NCBI chr 1:266,676,051...267,216,847
Ensembl chr 1:266,675,852...267,216,842

G

antizyme inhibitor 2

affects expression

EXP

Orphenadrine affects the expression of AZIN2 mRNA

NCBI chr 5:146,568,187...146,594,777
Ensembl chr 5:146,565,437...146,594,777

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

affects expression

EXP

Orphenadrine affects the expression of B3GNT9 mRNA

NCBI chr19:50,039,649...50,042,206
Ensembl chr19:50,030,866...50,043,339

G

beta-1,4-galactosyltransferase 6

affects expression

EXP

Orphenadrine affects the expression of B4GALT6 mRNA

NCBI chr18:12,233,350...12,290,204
Ensembl chr18:12,233,351...12,290,204

G

BMP and activin membrane-bound inhibitor

affects expression

EXP

Orphenadrine affects the expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247

G

Bcl-2 binding component 3

affects expression

EXP

Orphenadrine affects the expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL6, transcription repressor

affects expression

EXP

Orphenadrine affects the expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

beta-carotene oxygenase 2

affects expression

EXP

Orphenadrine affects the expression of BCO2 mRNA

NCBI chr 8:59,778,571...59,803,597
Ensembl chr 8:59,778,575...59,799,168

G

basic helix-loop-helix family, member a15

affects expression

EXP

Orphenadrine affects the expression of BHLHA15 mRNA

NCBI chr12:15,534,123...15,538,299
Ensembl chr12:15,534,123...15,538,515

G

BicC family RNA binding protein 1

affects expression

EXP

Orphenadrine affects the expression of BICC1 mRNA

NCBI chr20:17,448,745...17,685,887
Ensembl chr20:17,448,765...17,685,885

G

bone morphogenetic protein 4

affects expression

EXP

Orphenadrine affects the expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172

G

BTB domain containing 7

affects expression

EXP

Orphenadrine affects the expression of BTBD7 mRNA

NCBI chr 6:127,685,185...127,774,947
Ensembl chr 6:127,688,421...127,737,222

G

similar to human chromosome 11 open reading frame 24

affects expression

EXP

Orphenadrine affects the expression of C1H11ORF24 mRNA

NCBI chr 1:210,374,426...210,383,191
Ensembl chr 1:210,374,543...210,383,566

G

C1q and TNF related 2

affects expression

EXP

Orphenadrine affects the expression of C1QTNF2 mRNA

NCBI chr10:28,443,326...28,460,400
Ensembl chr10:28,443,425...28,460,395

G

similar to human chromosome 15 open reading frame 39

affects expression

EXP

Orphenadrine affects the expression of C8H15ORF39 mRNA

NCBI chr 8:66,542,269...66,551,835
Ensembl chr 8:66,542,269...66,554,782

G

carbonic anhydrase 1

affects expression

EXP

Orphenadrine affects the expression of CA1 mRNA

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

carbonic anhydrase 3

affects expression

EXP

Orphenadrine affects the expression of CA3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

calcitonin receptor like receptor

affects expression

EXP

Orphenadrine affects the expression of CALCRL mRNA

NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350

G

carbonic anhydrase 2

affects expression

EXP

Orphenadrine affects the expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase recruitment domain family, member 19

affects expression

EXP

Orphenadrine affects the expression of CARD19 mRNA

NCBI chr17:15,638,973...15,651,720
Ensembl chr17:15,639,012...15,651,720

G

caspase 2

affects expression

EXP

Orphenadrine affects the expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

Cbl proto-oncogene C

affects expression

EXP

Orphenadrine affects the expression of CBLC mRNA

NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:88,567,932...88,584,709

G

chromobox 4

affects expression

EXP

Orphenadrine affects the expression of CBX4 mRNA

NCBI chr10:104,835,685...104,841,727
Ensembl chr10:104,835,685...104,841,727

G

coiled-coil domain containing 68

affects expression

EXP

Orphenadrine affects the expression of CCDC68 mRNA

NCBI chr18:65,817,232...65,859,529
Ensembl chr18:65,786,926...65,859,526

G

cellular communication network factor 1

affects expression

EXP

Orphenadrine affects the expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cyclin D1

multiple interactions

EXP

Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

affects expression

EXP

Orphenadrine affects the expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

CD24 molecule

affects expression

EXP

Orphenadrine affects the expression of CD24 mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

Cd276 molecule

affects expression

EXP

Orphenadrine affects the expression of CD276 mRNA

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

CD36 molecule

affects expression

EXP

Orphenadrine affects the expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

CDC42 effector protein 1

affects expression

EXP

Orphenadrine affects the expression of CDC42EP1 mRNA

NCBI chr 7:112,275,759...112,283,665
Ensembl chr 7:112,275,792...112,283,664

G

cadherin 3

affects expression

EXP

Orphenadrine affects the expression of CDH3 mRNA

NCBI chr19:51,303,414...51,353,900
Ensembl chr19:51,300,083...51,354,257

G

cerebellar degeneration-related protein 2

affects expression

EXP

Orphenadrine affects the expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:184,934,129...184,968,863

G

carboxylesterase 2H

affects expression

EXP

Orphenadrine affects the expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

cilia and flagella associated protein 68

affects expression

EXP

Orphenadrine affects the expression of CFAP68 mRNA

NCBI chr 8:60,004,034...60,009,782
Ensembl chr 8:60,004,034...60,009,667

G

cell growth regulator with EF hand domain 1

affects expression

EXP

Orphenadrine affects the expression of CGREF1 mRNA

NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:31,151,795...31,163,800

G

charged multivesicular body protein 4C

affects expression

EXP

Orphenadrine affects the expression of CHMP4C mRNA

NCBI chr 2:93,299,152...93,336,075
Ensembl chr 2:93,299,157...93,360,850

G

cell death-inducing DFFA-like effector a

affects expression

EXP

Orphenadrine affects the expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

cytokine inducible SH2-containing protein

affects expression

EXP

Orphenadrine affects the expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

cardiotrophin-like cytokine factor 1

affects expression

EXP

Orphenadrine affects the expression of CLCF1 mRNA

NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:210,937,255...210,947,064

G

claudin 23

affects expression

EXP

Orphenadrine affects the expression of CLDN23 mRNA

NCBI chr16:63,117,045...63,118,769
Ensembl chr16:63,116,781...63,118,957

G

carnosine dipeptidase 1

affects expression

EXP

Orphenadrine affects the expression of CNDP1 mRNA

NCBI chr18:80,254,499...80,305,845
Ensembl chr18:80,255,784...80,282,643

G

collagen type IV alpha 3 chain

affects expression

EXP

Orphenadrine affects the expression of COL4A3 mRNA

NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:91,323,990...91,453,077

G

carnitine palmitoyltransferase 1B

affects expression

EXP

Orphenadrine affects the expression of CPT1B mRNA

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036

G

carnitine O-acetyltransferase

affects expression

EXP

Orphenadrine affects the expression of CRAT mRNA

NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099

G

cytokine receptor-like factor 2

affects expression

EXP

Orphenadrine affects the expression of CRLF2 mRNA

NCBI chr14:118,932...123,632
Ensembl chr14:115,497...123,631

G

crystallin, alpha B

affects expression

EXP

Orphenadrine affects the expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

crystallin, lambda 1

affects expression

EXP

Orphenadrine affects the expression of CRYL1 mRNA

NCBI chr15:35,542,628...35,661,563
Ensembl chr15:35,542,628...35,661,563

G

CUB and Sushi multiple domains 1

affects expression

EXP

Orphenadrine affects the expression of CSMD1 mRNA

NCBI chr16:78,920,549...80,520,710
Ensembl chr16:78,921,002...80,519,944

G

cysteine and serine rich nuclear protein 1

affects expression

EXP

Orphenadrine affects the expression of CSRNP1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:128,582,365...128,588,469

G

cystatin 9-like

affects expression

EXP

Orphenadrine affects the expression of CST9L mRNA

NCBI chr 3:156,741,232...156,744,045
Ensembl chr 3:156,741,232...156,744,045

G

CTP synthase 1

affects expression

EXP

Orphenadrine affects the expression of CTPS1 mRNA

NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:139,410,249...139,440,465

G

chymotrypsinogen B1

affects expression

EXP

Orphenadrine affects the expression of CTRB mRNA

NCBI chr19:56,562,220...56,566,978
Ensembl chr19:56,562,220...56,566,978

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
affects expression

EXP

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA
Orphenadrine affects the expression of CYP1A1 mRNA

PMID:23665939 PMID:23665940

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO
EXP

Orphenadrine inhibits the reaction [CYP1A2 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP1A2 protein
Orphenadrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

PMID:9241656 PMID:18493746

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 15

affects expression

EXP

Orphenadrine affects the expression of CYP2B15 mRNA

NCBI chr 1:91,221,865...91,234,169
Ensembl chr 1:91,221,865...91,234,169

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression
multiple interactions

EXP

Orphenadrine affects the expression of CYP2B2 mRNA
[Orphenadrine co-treated with Phenobarbital] affects the expression of CYP2B2 mRNA

PMID:23665939 PMID:23665940

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases activity

ISO

Orphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP2B6 protein

PMID:9241656 PMID:12464242 PMID:15306208

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily c, polypeptide 12

affects expression

EXP

Orphenadrine affects the expression of CYP2C12 mRNA

NCBI chr 1:248,619,887...248,681,945
Ensembl chr 1:248,619,882...248,677,042

G

cytochrome P450, family 2, subfamily c, polypeptide 24

affects expression

EXP

Orphenadrine affects the expression of CYP2C24 mRNA

NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

ISO

Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 62

affects expression

EXP

Orphenadrine affects the expression of CYP3A62 mRNA

NCBI chr12:21,511,763...21,547,598
Ensembl chr12:21,471,542...21,547,598

G

cytochrome P450, family 4, subfamily a, polypeptide 1

affects expression

EXP

Orphenadrine affects the expression of CYP4A1 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

EXP

Orphenadrine affects the expression of CYP4A8 mRNA

NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:133,938,883...133,970,226

G

cytochrome P450, family 4, subfamily b, polypeptide 1

affects expression

EXP

Orphenadrine affects the expression of CYP4B1 mRNA

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

cytochrome P450, family 4, subfamily f, polypeptide 37

affects expression

EXP

Orphenadrine affects the expression of CYP4F37 mRNA

NCBI chr 7:12,223,085...12,262,381
Ensembl chr 7:12,224,798...12,245,536

G

cytochrome P450, family 4, subfamily f, polypeptide 5

affects expression

EXP

Orphenadrine affects the expression of CYP4F5 mRNA

NCBI chr 7:12,194,567...12,209,495
Ensembl chr 7:12,195,022...12,209,965

G

cytochrome P450 family 7 subfamily A member 1

affects expression

EXP

Orphenadrine affects the expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 8 subfamily B member 1

affects expression

EXP

Orphenadrine affects the expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

cysteine-rich transmembrane module containing 1

affects expression

EXP

Orphenadrine affects the expression of CYSTM1 mRNA

NCBI chr18:28,219,861...28,287,574
Ensembl chr18:28,220,004...28,287,574

G

cysteine and tyrosine rich 1

affects expression

EXP

Orphenadrine affects the expression of CYYR1 mRNA

NCBI chr11:38,044,003...38,150,391
Ensembl chr11:38,001,699...38,164,473

G

dishevelled-binding antagonist of beta-catenin 2

affects expression

EXP

Orphenadrine affects the expression of DACT2 mRNA

NCBI chr 1:63,854,182...63,864,153
Ensembl chr 1:63,854,182...63,864,255

G

defensin beta 36

affects expression

EXP

Orphenadrine affects the expression of DEFB36 mRNA

NCBI chr 3:161,538,276...161,547,107
Ensembl chr 3:161,538,178...161,548,694

G

disco-interacting protein 2 homolog A

affects expression

EXP

Orphenadrine affects the expression of DIP2A mRNA

NCBI chr20:12,284,037...12,373,519
Ensembl chr20:12,284,038...12,370,532

G

delta like canonical Notch ligand 1

affects expression

EXP

Orphenadrine affects the expression of DLL1 mRNA

NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:64,985,161...64,993,276

G

dynein heavy chain domain 1

affects expression

EXP

Orphenadrine affects the expression of DNHD1 mRNA

NCBI chr 1:169,402,615...169,486,684
Ensembl chr 1:169,394,884...169,487,646

G

dipeptidyl peptidase like 6

affects expression

EXP

Orphenadrine affects the expression of DPP6 mRNA

NCBI chr 4:8,323,220...9,242,694
Ensembl chr 4:8,324,843...9,242,209

G

developmental pluripotency associated 3 like 2

affects expression

EXP

Orphenadrine affects the expression of DPPA3L2 mRNA

NCBI chr17:2,890,838...2,892,855

G

DNA-damage regulated autophagy modulator 1

affects expression

EXP

Orphenadrine affects the expression of DRAM1 mRNA

NCBI chr 7:24,630,233...24,665,270
Ensembl chr 7:24,630,238...24,664,354

G

dual specificity phosphatase 1

affects expression

EXP

Orphenadrine affects the expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 10

affects expression

EXP

Orphenadrine affects the expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

dual specificity phosphatase 13B

affects expression

EXP

Orphenadrine affects the expression of DUSP13B mRNA

NCBI chr15:2,616,761...2,624,434
Ensembl chr15:2,609,049...2,624,887

G

dual specificity phosphatase 16

affects expression

EXP

Orphenadrine affects the expression of DUSP16 mRNA

NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:169,278,118...169,361,508

G

dual specificity phosphatase 8

affects expression

EXP

Orphenadrine affects the expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:206,598,942...206,612,441

G

estrogen-induced osteoclastogenesis regulator 1

affects expression

EXP

Orphenadrine affects the expression of EEIG1 mRNA

NCBI chr 3:36,220,170...36,252,377
Ensembl chr 3:36,211,730...36,252,378

G

EEIG family member 2

affects expression

EXP

Orphenadrine affects the expression of EEIG2 mRNA

NCBI chr 2:199,296,582...199,351,449
Ensembl chr 2:199,296,582...199,351,449

G

EGF containing fibulin extracellular matrix protein 1

affects expression

EXP

Orphenadrine affects the expression of EFEMP1 mRNA

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808

G

egl-9 family hypoxia-inducible factor 3

affects expression

EXP

Orphenadrine affects the expression of EGLN3 mRNA

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015

G

early growth response 1

affects expression

EXP

Orphenadrine affects the expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

elastin microfibril interfacer 1

affects expression

EXP

Orphenadrine affects the expression of EMILIN1 mRNA

NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:31,175,919...31,183,657

G

Eph receptor A2

affects expression

EXP

Orphenadrine affects the expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234

G

EPH receptor B4

affects expression

EXP

Orphenadrine affects the expression of EPHB4 mRNA

NCBI chr12:24,963,174...24,988,473
Ensembl chr12:24,963,174...24,988,388

G

ERI1 exoribonuclease family member 2

affects expression

EXP

Orphenadrine affects the expression of ERI2 mRNA

NCBI chr 1:183,551,919...183,600,134
Ensembl chr 1:183,573,357...183,600,185

G

coagulation factor VIII

affects expression

EXP

Orphenadrine affects the expression of F8 mRNA

NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683

G

family with sequence similarity 89, member A

affects expression

EXP

Orphenadrine affects the expression of FAM89A mRNA

NCBI chr19:69,607,391...69,620,019
Ensembl chr19:69,607,391...69,620,019

G

F-box protein 27

affects expression

EXP

Orphenadrine affects the expression of FBXO27 mRNA

NCBI chr 1:93,092,900...93,115,312
Ensembl chr 1:93,093,024...93,122,181

G

fer-1-like family member 5

affects expression

EXP

Orphenadrine affects the expression of FER1L5 mRNA

NCBI chr 9:46,101,798...46,156,483
Ensembl chr 9:46,103,760...46,156,479

G

FYVE, RhoGEF and PH domain containing 5

affects expression

EXP

Orphenadrine affects the expression of FGD5 mRNA

NCBI chr 4:126,054,201...126,151,698
Ensembl chr 4:126,054,210...126,151,697

G

Fms related receptor tyrosine kinase 1

affects expression

EXP

Orphenadrine affects the expression of FLT1 mRNA

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

Fms related receptor tyrosine kinase 4

affects expression

EXP

Orphenadrine affects the expression of FLT4 mRNA

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645

G

flavin containing dimethylaniline monoxygenase 1

affects expression

EXP

Orphenadrine affects the expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

fibronectin type III domain containing 5

affects expression

EXP

Orphenadrine affects the expression of FNDC5 mRNA

NCBI chr 5:146,765,951...146,775,611
Ensembl chr 5:146,751,416...146,778,540

G

follistatin

affects expression

EXP

Orphenadrine affects the expression of FST mRNA

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:47,856,345...47,863,491

G

growth arrest and DNA-damage-inducible, gamma

affects expression

EXP

Orphenadrine affects the expression of GADD45G mRNA

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369

G

growth differentiation factor 11

affects expression

EXP

Orphenadrine affects the expression of GDF11 mRNA

NCBI chr 7:1,896,229...1,909,147
Ensembl chr 7:1,896,229...1,905,222

G

gamma-glutamyltransferase 1

affects expression

EXP

Orphenadrine affects the expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

GIMAP family P-loop NTPase domain containing 1

affects expression

EXP

Orphenadrine affects the expression of GIMD1 mRNA

NCBI chr 2:223,777,876...223,812,582
Ensembl chr 2:223,777,889...223,812,576

G

GIPC PDZ domain containing family, member 2

affects expression

EXP

Orphenadrine affects the expression of GIPC2 mRNA

NCBI chr 2:243,690,742...243,770,199
Ensembl chr 2:243,690,748...243,770,199

G

Gem-interacting protein

affects expression

EXP

Orphenadrine affects the expression of GMIP mRNA

NCBI chr16:19,634,630...19,648,916
Ensembl chr16:19,634,630...19,647,933

G

G protein subunit alpha 14

affects expression

EXP

Orphenadrine affects the expression of GNA14 mRNA

NCBI chr 1:223,141,802...223,324,210
Ensembl chr 1:223,141,802...223,324,210

G

G protein subunit alpha i1

affects expression

EXP

Orphenadrine affects the expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198

G

glycerol-3-phosphate acyltransferase 3

affects expression

EXP

Orphenadrine affects the expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552

G

G protein-coupled receptor 17

affects expression

EXP

Orphenadrine affects the expression of GPR17 mRNA

NCBI chr18:23,850,460...23,857,381
Ensembl chr18:23,850,107...23,857,702

G

glutathione peroxidase 2

affects expression
multiple interactions

EXP

Orphenadrine affects the expression of GPX2 mRNA
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA

PMID:23665939 PMID:23665940

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutamate ionotropic receptor AMPA type subunit 3

affects expression

EXP

Orphenadrine affects the expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:125,103,782...125,369,679

G

glutamate ionotropic receptor kainate type subunit 5

affects expression

EXP

Orphenadrine affects the expression of GRIK5 mRNA

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:89,733,741...89,794,962

G

Gse1 coiled-coil protein

affects expression

EXP

Orphenadrine affects the expression of GSE1 mRNA

NCBI chr19:65,182,678...65,538,183
Ensembl chr19:65,446,263...65,538,176

G

glutathione S-transferase mu 4

affects expression

EXP

Orphenadrine affects the expression of GSTM4 mRNA

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638

G

glutathione S-transferase, mu 5

multiple interactions
affects expression

EXP

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA
Orphenadrine affects the expression of GSTM3 mRNA

PMID:23665939 PMID:23665940

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase pi 1

affects expression

EXP

Orphenadrine affects the expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

histidine ammonia lyase

affects expression

EXP

Orphenadrine affects the expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

heme binding protein 2

affects expression

EXP

Orphenadrine affects the expression of HEBP2 mRNA

NCBI chr 1:15,014,729...15,021,523
Ensembl chr 1:15,014,729...15,021,523

G

hes family bHLH transcription factor 1

affects expression

EXP

Orphenadrine affects the expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hepatocyte growth factor

affects expression

EXP

Orphenadrine affects the expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

HID1 domain containing

affects expression

EXP

Orphenadrine affects the expression of HID1 mRNA

NCBI chr10:101,088,526...101,109,011
Ensembl chr10:101,088,526...101,109,011

G

heat shock protein family A (Hsp70) member 1A

affects expression

EXP

Orphenadrine affects the expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

affects expression

EXP

Orphenadrine affects the expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

hyccin PI4KA lipid kinase complex subunit 1

affects expression

EXP

Orphenadrine affects the expression of HYCC1 mRNA

NCBI chr 4:12,024,692...12,131,504
Ensembl chr 4:12,024,739...12,131,501

G

inhibitor of DNA binding 1

affects expression

EXP

Orphenadrine affects the expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 3

affects expression

EXP

Orphenadrine affects the expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

indoleamine 2,3-dioxygenase 2

affects expression

EXP

Orphenadrine affects the expression of IDO2 mRNA

NCBI chr16:74,161,761...74,200,651
Ensembl chr16:74,161,774...74,200,650

G

immediate early response 5

affects expression

EXP

Orphenadrine affects the expression of IER5 mRNA

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:69,820,451...69,822,543

G

insulin-like growth factor binding protein 1

affects expression

EXP

Orphenadrine affects the expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

Indian hedgehog signaling molecule

affects expression

EXP

Orphenadrine affects the expression of IHH mRNA

NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects expression

EXP

Orphenadrine affects the expression of IKBKG mRNA

NCBI chr X:157,358,279...157,397,563
Ensembl chr X:157,367,639...157,392,757

G

interleukin 17 receptor B

affects expression

EXP

Orphenadrine affects the expression of IL17RB mRNA

NCBI chr16:5,186,961...5,200,657
Ensembl chr16:5,186,961...5,200,694

G

interleukin 33

affects expression

EXP

Orphenadrine affects the expression of IL33 mRNA

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901

G

inverted formin 2

affects expression

EXP

Orphenadrine affects the expression of INF2 mRNA

NCBI chr 6:137,470,259...137,497,039
Ensembl chr 6:137,470,286...137,497,039

G

inositol hexakisphosphate kinase 2

affects expression

EXP

Orphenadrine affects the expression of IP6K2 mRNA

NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:118,362,795...118,388,667

G

interferon regulatory factor 7

affects expression

EXP

Orphenadrine affects the expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

iroquois homeobox 1

affects expression

EXP

Orphenadrine affects the expression of IRX1 mRNA

NCBI chr 1:33,123,122...33,128,951
Ensembl chr 1:33,123,122...33,128,951

G

ISG15 ubiquitin-like modifier

affects expression

EXP

Orphenadrine affects the expression of ISG15 mRNA

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656

G

integrin subunit beta 3

affects expression

EXP

Orphenadrine affects the expression of ITGB3 mRNA

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

EXP

Orphenadrine affects the expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

affects expression

EXP

Orphenadrine affects the expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

type I keratin KA11

affects expression

EXP

Orphenadrine affects the expression of KA11 mRNA

NCBI chr10:85,661,820...85,667,785
Ensembl chr10:85,638,182...85,664,898

G

KN motif and ankyrin repeat domains 2

affects expression

EXP

Orphenadrine affects the expression of KANK2 mRNA

NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:28,587,770...28,616,993

G

potassium inwardly-rectifying channel, subfamily J, member 15

affects expression

EXP

Orphenadrine affects the expression of KCNJ15 mRNA

NCBI chr11:48,046,953...48,091,285
Ensembl chr11:48,035,655...48,092,457

G

potassium two pore domain channel subfamily K member 5

affects expression

EXP

Orphenadrine affects the expression of KCNK5 mRNA

NCBI chr15:4,171,625...4,213,896
Ensembl chr15:4,171,610...4,213,897

G

KLF transcription factor 10

affects expression

EXP

Orphenadrine affects the expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

kelch-like family member 21

affects expression

EXP

Orphenadrine affects the expression of KLHL21 mRNA

NCBI chr 5:167,797,621...167,806,276
Ensembl chr 5:167,797,591...167,806,276

G

kynurenine 3-monooxygenase

affects expression

EXP

Orphenadrine affects the expression of KMO mRNA

NCBI chr13:90,089,340...90,121,108
Ensembl chr13:90,089,463...90,125,151

G

keratin 10

affects expression

EXP

Orphenadrine affects the expression of KRT10 mRNA

NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,834,840...84,839,160

G

keratin 8

affects expression

EXP

Orphenadrine affects the expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

lymphocyte activating 3

affects expression

EXP

Orphenadrine affects the expression of LAG3 mRNA

NCBI chr 4:159,398,930...159,407,001
Ensembl chr 4:159,398,932...159,406,669

G

leucine, glutamate and lysine rich 1

affects expression

EXP

Orphenadrine affects the expression of LEKR1 mRNA

NCBI chr 2:152,195,003...152,376,389
Ensembl chr 2:152,201,182...152,370,542

G

galectin 2

affects expression

EXP

Orphenadrine affects the expression of LGALS2 mRNA

NCBI chr 7:112,283,630...112,290,228
Ensembl chr 7:112,282,822...112,285,392

G

LIM homeobox 8

affects expression

EXP

Orphenadrine affects the expression of LHX8 mRNA

NCBI chr 2:245,904,712...245,929,376
Ensembl chr 2:245,904,712...245,929,376

G

leukocyte immunoglobulin like receptor B4

affects expression

EXP

Orphenadrine affects the expression of LILRB4 mRNA

NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:78,847,685...78,853,326

G

lin-7 homolog A, crumbs cell polarity complex component

affects expression

EXP

Orphenadrine affects the expression of LIN7A mRNA

NCBI chr 7:44,473,568...44,629,074
Ensembl chr 7:44,473,347...44,625,208

G

leiomodin 2

affects expression

EXP

Orphenadrine affects the expression of LMOD2 mRNA

NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:54,032,974...54,040,666

G

lysyl oxidase-like 4

affects expression

EXP

Orphenadrine affects the expression of LOXL4 mRNA

NCBI chr 1:251,345,445...251,365,640
Ensembl chr 1:251,347,238...251,365,577

G

lysophosphatidylcholine acyltransferase 4

affects expression

EXP

Orphenadrine affects the expression of LPCAT4 mRNA

NCBI chr 3:119,499,128...119,507,275
Ensembl chr 3:119,499,128...119,507,362

G

lipin 2

affects expression

EXP

Orphenadrine affects the expression of LPIN2 mRNA

NCBI chr 9:118,529,988...118,604,796
Ensembl chr 9:118,529,943...118,604,796

G

lipoprotein lipase

affects expression

EXP

Orphenadrine affects the expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine rich repeat neuronal 4

affects expression

EXP

Orphenadrine affects the expression of LRRN4 mRNA

NCBI chr 3:140,592,303...140,603,986
Ensembl chr 3:140,592,076...140,605,574

G

leukotriene C4 synthase

affects expression

EXP

Orphenadrine affects the expression of LTC4S mRNA

NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768

G

MAF bZIP transcription factor B

affects expression

EXP

Orphenadrine affects the expression of MAFB mRNA

NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975

G

MAGE family member E1

affects expression

EXP

Orphenadrine affects the expression of MAGEE1 mRNA

NCBI chr X:74,254,848...74,258,395
Ensembl chr X:74,254,958...74,258,371

G

microtubule-associated protein 1S

affects expression

EXP

Orphenadrine affects the expression of MAP1S mRNA

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,551,573...18,562,141

G

mitogen activated protein kinase kinase kinase kinase 2

affects expression

EXP

Orphenadrine affects the expression of MAP4K2 mRNA

NCBI chr 1:213,074,360...213,090,042
Ensembl chr 1:213,074,377...213,096,987

G

mitogen-activated protein kinase kinase kinase kinase 4

affects expression

EXP

Orphenadrine affects the expression of MAP4K4 mRNA

NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:49,696,700...49,822,353

G

mitogen-activated protein kinase 12

affects expression

EXP

Orphenadrine affects the expression of MAPK12 mRNA

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

matrilin 4

affects expression

EXP

Orphenadrine affects the expression of MATN4 mRNA

NCBI chr 3:173,539,966...173,554,984
Ensembl chr 3:173,539,966...173,554,984

G

melanoma cell adhesion molecule

affects expression

EXP

Orphenadrine affects the expression of MCAM mRNA

NCBI chr 8:53,376,225...53,384,407
Ensembl chr 8:53,376,197...53,384,406

G

methionyl aminopeptidase type 1D (mitochondrial)

affects expression

EXP

Orphenadrine affects the expression of METAP1D mRNA

NCBI chr 3:76,687,149...76,759,681
Ensembl chr 3:76,687,171...76,759,655

G

mex-3 RNA binding family member B

affects expression

EXP

Orphenadrine affects the expression of MEX3B mRNA

NCBI chr 1:146,264,319...146,268,554
Ensembl chr 1:146,264,318...146,268,543

G

mex-3 RNA binding family member D

affects expression

EXP

Orphenadrine affects the expression of MEX3D mRNA

NCBI chr 7:9,976,253...9,983,383
Ensembl chr 7:9,976,253...9,983,383

G

milk fat globule EGF and factor V/VIII domain containing

affects expression

EXP

Orphenadrine affects the expression of MFGE8 mRNA

NCBI chr 1:142,474,027...142,489,431
Ensembl chr 1:142,474,028...142,489,431

G

midline 1

affects expression

EXP

Orphenadrine affects the expression of MID1 mRNA

NCBI chr X:27,678,248...28,053,049
Ensembl chr X:27,681,867...27,906,105

G

MID1 interacting protein 1

affects expression

EXP

Orphenadrine affects the expression of MID1IP1 mRNA

NCBI chr X:14,733,539...14,735,859
Ensembl chr X:14,732,830...14,739,079

G

midnolin

affects expression

EXP

Orphenadrine affects the expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:10,200,306...10,207,203

G

MAPK interacting serine/threonine kinase 2

affects expression

EXP

Orphenadrine affects the expression of MKNK2 mRNA

NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,690,421...9,701,529

G

MLX interacting protein

affects expression

EXP

Orphenadrine affects the expression of MLXIP mRNA

NCBI chr12:38,789,404...38,853,059
Ensembl chr12:38,789,404...38,853,059

G

monocyte to macrophage differentiation-associated

affects expression

EXP

Orphenadrine affects the expression of MMD mRNA

NCBI chr10:75,570,366...75,598,610
Ensembl chr10:75,570,397...75,598,609

G

matrix metallopeptidase 12

affects expression

EXP

Orphenadrine affects the expression of MMP12 mRNA

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478

G

matrix metallopeptidase 15

affects expression

EXP

Orphenadrine affects the expression of MMP15 mRNA

NCBI chr19:9,669,506...9,691,000
Ensembl chr19:9,669,506...9,691,000

G

muscle RAS oncogene homolog

affects expression

EXP

Orphenadrine affects the expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911

G

maestro heat-like repeat family member 2A

affects expression

EXP

Orphenadrine affects the expression of MROH2A mRNA

NCBI chr 9:96,262,307...96,309,036
Ensembl chr 9:96,262,271...96,301,635

G

macrophage stimulating 1 receptor

affects expression

EXP

Orphenadrine affects the expression of MST1R mRNA

NCBI chr 8:117,471,928...117,491,059
Ensembl chr 8:117,475,968...117,490,515

G

myotubularin related protein 7

affects expression

EXP

Orphenadrine affects the expression of MTMR7 mRNA

NCBI chr16:58,344,755...58,435,682
Ensembl chr16:58,344,767...58,436,615

G

MTSS I-BAR domain containing 2

affects expression

EXP

Orphenadrine affects the expression of MTSS2 mRNA

NCBI chr19:55,602,180...55,623,955
Ensembl chr19:55,602,498...55,623,950

G

MX dynamin like GTPase 2

affects expression

EXP

Orphenadrine affects the expression of MX2 mRNA

NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478

G

myosin binding protein H

affects expression

EXP

Orphenadrine affects the expression of MYBPH mRNA

NCBI chr13:48,205,162...48,212,928
Ensembl chr13:48,205,269...48,212,928

G

Myb-related transcription factor, partner of profilin

affects expression

EXP

Orphenadrine affects the expression of MYPOP mRNA

NCBI chr 1:87,767,747...87,778,602

G

myelin regulatory factor

affects expression

EXP

Orphenadrine affects the expression of MYRF mRNA

NCBI chr 1:216,279,057...216,311,155
Ensembl chr 1:216,279,057...216,311,178

G

N-acetyltransferase 8 (GCN5-related) family member 2

affects expression

EXP

Orphenadrine affects the expression of NAT8F2 mRNA

NCBI chr 4:119,877,449...119,880,685
Ensembl chr 4:119,877,465...119,890,291

G

non-SMC condensin I complex, subunit H

affects expression

EXP

Orphenadrine affects the expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:134,825,271...134,852,502

G

nuclear receptor coactivator 7

affects expression

EXP

Orphenadrine affects the expression of NCOA7 mRNA

NCBI chr 1:28,674,614...28,835,891
Ensembl chr 1:28,675,426...28,835,886

G

neurofilament heavy chain

affects expression

EXP

Orphenadrine affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

neuralized E3 ubiquitin protein ligase 3

affects expression

EXP

Orphenadrine affects the expression of NEURL3 mRNA

NCBI chr 9:45,990,373...45,998,470
Ensembl chr 9:45,990,375...45,998,535

G

NFKB inhibitor zeta

affects expression

EXP

Orphenadrine affects the expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767

G

NHS like 3

affects expression

EXP

Orphenadrine affects the expression of NHSL3 mRNA

NCBI chr 5:146,848,747...146,877,504
Ensembl chr 5:146,848,747...146,877,504

G

ninjurin 2

affects expression

EXP

Orphenadrine affects the expression of NINJ2 mRNA

NCBI chr 4:154,978,660...155,080,860
Ensembl chr 4:155,073,295...155,080,860

G

NIPA-like domain containing 2

affects expression

EXP

Orphenadrine affects the expression of NIPAL2 mRNA

NCBI chr 7:67,659,628...67,771,105
Ensembl chr 7:67,659,628...67,769,959

G

NLR family, CARD domain containing 4

affects expression

EXP

Orphenadrine affects the expression of NLRC4 mRNA

NCBI chr 6:26,743,658...26,771,783
Ensembl chr 6:26,743,698...26,770,563

G

nocturnin

affects expression

EXP

Orphenadrine affects the expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282

G

nitric oxide synthase 1 adaptor protein

affects expression

EXP

Orphenadrine affects the expression of NOS1AP mRNA

NCBI chr13:85,080,558...85,353,741
Ensembl chr13:85,063,350...85,353,741

G

nitric oxide synthase 3

affects expression

EXP

Orphenadrine affects the expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

neuropeptide Y

affects expression

EXP

Orphenadrine affects the expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

nuclear receptor subfamily 1, group D, member 1

affects expression

EXP

Orphenadrine affects the expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

neuronal regeneration related protein

affects expression

EXP

Orphenadrine affects the expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

neuregulin 1

affects expression

EXP

Orphenadrine affects the expression of NRG1 mRNA

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neurexin 1

affects expression

EXP

Orphenadrine affects the expression of NRXN1 mRNA

NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:8,935,523...10,077,374

G

nuclear protein 1, transcriptional regulator

affects expression

EXP

Orphenadrine affects the expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

ornithine aminotransferase

affects expression

EXP

Orphenadrine affects the expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

osteoglycin

affects expression

EXP

Orphenadrine affects the expression of OGN mRNA

NCBI chr17:15,238,500...15,259,167
Ensembl chr17:15,238,500...15,259,252

G

olfactory receptor 1198

affects expression

EXP

Orphenadrine affects the expression of OLR1198 mRNA

NCBI chr 8:45,764,097...45,765,026
Ensembl chr 8:45,764,097...45,765,026

G

olfactory receptor 1428

affects expression

EXP

Orphenadrine affects the expression of OLR1428 mRNA

NCBI chr10:43,447,769...43,448,716
Ensembl chr10:43,447,769...43,448,716

G

olfactory receptor 1451

affects expression

EXP

Orphenadrine affects the expression of OLR1451 mRNA

NCBI chr10:43,928,730...43,929,659
Ensembl chr10:43,928,730...43,929,659

G

osteomodulin

affects expression

EXP

Orphenadrine affects the expression of OMD mRNA

NCBI chr17:15,266,646...15,274,870
Ensembl chr17:15,266,646...15,274,870

G

olfactory receptor family 2 subfamily N member 1L

affects expression

EXP

Orphenadrine affects the expression of OR2N1L mRNA

NCBI chr20:345,864...346,802
Ensembl chr20:302,333...359,996

G

olfactory receptor family 2 subfamily Y member 1I

affects expression

EXP

Orphenadrine affects the expression of OR2Y1I mRNA

NCBI chr10:34,238,313...34,239,242

G

oxidative stress induced growth inhibitor 1

affects expression

EXP

Orphenadrine affects the expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

prolyl 3-hydroxylase 2

affects expression

EXP

Orphenadrine affects the expression of P3H2 mRNA

NCBI chr11:88,139,086...88,280,221
Ensembl chr11:88,139,078...88,281,203

G

prolyl 3-hydroxylase family member 4

affects expression

EXP

Orphenadrine affects the expression of P3H4 mRNA

NCBI chr10:85,838,528...85,845,476
Ensembl chr10:85,838,528...85,845,476

G

pannexin 2

affects expression

EXP

Orphenadrine affects the expression of PANX2 mRNA

NCBI chr 7:122,018,937...122,032,009
Ensembl chr 7:122,018,937...122,032,004

G

probasin

affects expression

EXP

Orphenadrine affects the expression of PBSN mRNA

NCBI chr X:45,792,738...45,807,983
Ensembl chr X:45,792,738...45,807,983

G

protocadherin 12

affects expression

EXP

Orphenadrine affects the expression of PCDH12 mRNA

NCBI chr18:30,354,910...30,370,485
Ensembl chr18:30,354,910...30,370,485

G

Purkinje cell protein 4-like 1

affects expression

EXP

Orphenadrine affects the expression of PCP4L1 mRNA

NCBI chr13:86,121,463...86,145,097
Ensembl chr13:86,121,464...86,144,899

G

proprotein convertase subtilisin/kexin type 9

affects expression

EXP

Orphenadrine affects the expression of PCSK9 mRNA

NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507

G

phosphodiesterase 5A

affects expression

EXP

Orphenadrine affects the expression of PDE5A mRNA

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

pyruvate dehydrogenase kinase 4

affects expression

EXP

Orphenadrine affects the expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

podoplanin

affects expression

EXP

Orphenadrine affects the expression of PDPN mRNA

NCBI chr 5:160,884,995...160,919,112
Ensembl chr 5:160,884,993...160,925,637

G

period circadian regulator 2

affects expression

EXP

Orphenadrine affects the expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

phosphofructokinase, muscle

affects expression

EXP

Orphenadrine affects the expression of PFKM mRNA

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

pleckstrin homology-like domain, family A, member 2

affects expression

EXP

Orphenadrine affects the expression of PHLDA2 mRNA

NCBI chr 1:208,126,302...208,127,241
Ensembl chr 1:208,126,302...208,127,920

G

pleckstrin homology-like domain, family A, member 3

affects expression

EXP

Orphenadrine affects the expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

pleckstrin homology-like domain, family B, member 3

affects expression

EXP

Orphenadrine affects the expression of PHLDB3 mRNA

NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:89,328,819...89,347,436

G

phosphoethanolamine/phosphocholine phosphatase 1

affects expression

EXP

Orphenadrine affects the expression of PHOSPHO1 mRNA

NCBI chr10:81,258,810...81,266,345
Ensembl chr10:81,257,427...81,268,481

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

affects expression

EXP

Orphenadrine affects the expression of PIP5K1C mRNA

NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716

G

pleckstrin homology and FYVE domain containing 2

affects expression

EXP

Orphenadrine affects the expression of PLEKHF2 mRNA

NCBI chr 5:28,888,358...28,905,350
Ensembl chr 5:28,868,469...28,923,514

G

pleckstrin homology, MyTH4 and FERM domain containing H1

affects expression

EXP

Orphenadrine affects the expression of PLEKHH1 mRNA

NCBI chr 6:103,572,304...103,621,729
Ensembl chr 6:103,572,291...103,621,728

G

perilipin 3

affects expression

EXP

Orphenadrine affects the expression of PLIN3 mRNA

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,198,336...1,210,231

G

prostate transmembrane protein, androgen induced 1

affects expression

EXP

Orphenadrine affects the expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649

G

peripheral myelin protein 22

affects expression

EXP

Orphenadrine affects the expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940

G

DNA polymerase gamma 2, accessory subunit

affects expression

EXP

Orphenadrine affects the expression of POLG2 mRNA

NCBI chr10:92,212,303...92,222,849
Ensembl chr10:92,212,304...92,222,726

G

protein phosphatase, Mg2+/Mn2+ dependent, 1J

affects expression

EXP

Orphenadrine affects the expression of PPM1J mRNA

NCBI chr 2:194,966,854...194,972,228
Ensembl chr 2:194,966,950...194,972,227

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

affects expression

EXP

Orphenadrine affects the expression of PPM1K mRNA

NCBI chr 4:88,942,226...88,969,139
Ensembl chr 4:88,942,386...88,969,136

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

affects expression

EXP

Orphenadrine affects the expression of PPP1R1A mRNA

NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:136,523,604...136,540,683

G

PRELI domain containing 2

affects expression

EXP

Orphenadrine affects the expression of PRELID2 mRNA

NCBI chr18:34,120,989...34,212,699
Ensembl chr18:34,125,373...34,212,167

G

protein kinase C, eta

affects expression

EXP

Orphenadrine affects the expression of PRKCH mRNA

NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:98,027,646...98,226,477

G

prolactin receptor

affects expression

EXP

Orphenadrine affects the expression of PRLR mRNA

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

proline rich protein 2

affects expression

EXP

Orphenadrine affects the expression of PRP2 mRNA

NCBI chr 4:167,331,491...167,335,068
Ensembl chr 4:167,331,491...167,335,068

G

proline rich and Gla domain 4

affects expression

EXP

Orphenadrine affects the expression of PRRG4 mRNA

NCBI chr 3:111,669,508...111,698,205
Ensembl chr 3:111,673,582...111,698,205

G

serine protease 53

affects expression

EXP

Orphenadrine affects the expression of PRSS53 mRNA

NCBI chr 1:191,923,398...191,931,292
Ensembl chr 1:191,925,434...191,955,449

G

protein tyrosine phosphatase, receptor type, N

affects expression

EXP

Orphenadrine affects the expression of PTPRN mRNA

NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:84,189,676...84,204,850

G

PVR cell adhesion molecule

affects expression

EXP

Orphenadrine affects the expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630

G

PWWP domain containing 2B

affects expression

EXP

Orphenadrine affects the expression of PWWP2B mRNA

NCBI chr 1:203,470,172...203,489,575
Ensembl chr 1:203,470,928...203,489,549

G

RAB11 family interacting protein 5

affects expression

EXP

Orphenadrine affects the expression of RAB11FIP5 mRNA

NCBI chr 4:119,428,766...119,466,277
Ensembl chr 4:119,428,766...119,466,213

G

RAB23, member RAS oncogene family

affects expression

EXP

Orphenadrine affects the expression of RAB23 mRNA

NCBI chr 9:43,440,047...43,463,327
Ensembl chr 9:43,440,273...43,463,325

G

RAB3D, member RAS oncogene family

affects expression

EXP

Orphenadrine affects the expression of RAB3D mRNA

NCBI chr 8:28,714,706...28,725,379
Ensembl chr 8:28,716,241...28,725,317

G

retinoic acid receptor, gamma

affects expression

EXP

Orphenadrine affects the expression of RARG mRNA

NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:135,246,427...135,268,889

G

Ras association domain family member 1

affects expression

EXP

Orphenadrine affects the expression of RASSF1 mRNA

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

RELT-like 1

affects expression

EXP

Orphenadrine affects the expression of RELL1 mRNA

NCBI chr14:44,672,121...44,732,081
Ensembl chr14:44,672,224...44,732,088

G

renin binding protein

affects expression

EXP

Orphenadrine affects the expression of RENBP mRNA

NCBI chr X:156,812,785...156,821,860
Ensembl chr X:156,812,411...156,821,838

G

replication initiator 1

affects expression

EXP

Orphenadrine affects the expression of REPIN1 mRNA

NCBI chr 4:78,879,910...78,885,143
Ensembl chr 4:78,880,976...78,886,413

G

regulated endocrine-specific protein 18

affects expression

EXP

Orphenadrine affects the expression of RESP18 mRNA

NCBI chr 9:84,213,844...84,220,186
Ensembl chr 9:84,213,467...84,221,299

G

regulator of G-protein signaling 16

affects expression

EXP

Orphenadrine affects the expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

rhomboid 5 homolog 2

affects expression

EXP

Orphenadrine affects the expression of RHBDF2 mRNA

NCBI chr10:102,331,991...102,359,117
Ensembl chr10:102,331,991...102,359,117

G

ras homolog family member C

affects expression

EXP

Orphenadrine affects the expression of RHOC mRNA

NCBI chr 2:194,975,586...194,981,637
Ensembl chr 2:194,975,242...194,983,745

G

ras homolog family member F, filopodia associated

affects expression

EXP

Orphenadrine affects the expression of RHOF mRNA

NCBI chr12:39,082,413...39,107,528
Ensembl chr12:39,091,979...39,107,528

G

regulator of microtubule dynamics 2

affects expression

EXP

Orphenadrine affects the expression of RMDN2 mRNA

NCBI chr 6:21,101,383...21,195,221
Ensembl chr 6:21,119,396...21,193,684

G

Rho family GTPase 1

affects expression

EXP

Orphenadrine affects the expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

EXP

Orphenadrine affects the expression of SBSPON mRNA

NCBI chr 5:8,186,004...8,216,576
Ensembl chr 5:8,185,985...8,218,898

G

stearoyl-CoA desaturase

affects expression

EXP

Orphenadrine affects the expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

sodium channel epithelial 1 subunit alpha

affects expression

EXP

Orphenadrine affects the expression of SCNN1A mRNA

NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:159,809,170...159,832,405

G

syndecan 3

affects expression

EXP

Orphenadrine affects the expression of SDC3 mRNA

NCBI chr 5:148,249,792...148,282,524
Ensembl chr 5:148,271,842...148,280,614

G

short chain dehydrogenase/reductase family 16C, member 6

affects expression

EXP

Orphenadrine affects the expression of SDR16C6 mRNA

NCBI chr 5:21,892,783...21,916,314
Ensembl chr 5:21,892,783...22,062,233

G

SEBOX homeobox

affects expression

EXP

Orphenadrine affects the expression of SEBOX mRNA

NCBI chr10:63,897,265...63,898,136
Ensembl chr10:63,897,217...63,898,719

G

serine incorporator 2

affects expression

EXP

Orphenadrine affects the expression of SERINC2 mRNA

NCBI chr 5:147,876,477...147,898,797
Ensembl chr 5:147,876,477...147,902,765

G

serpin family A member 7

affects expression

EXP

Orphenadrine affects the expression of SERPINA7 mRNA

NCBI chr X:107,452,044...107,510,958
Ensembl chr X:107,452,044...107,457,681

G

SERTA domain containing 1

affects expression

EXP

Orphenadrine affects the expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001

G

SET domain containing 7, histone lysine methyltransferase

affects expression

EXP

Orphenadrine affects the expression of SETD7 mRNA

NCBI chr 2:137,713,545...137,756,319
Ensembl chr 2:137,713,545...137,756,319

G

serum/glucocorticoid regulated kinase 1

affects expression

EXP

Orphenadrine affects the expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

SH3 and PX domains 2B

affects expression

EXP

Orphenadrine affects the expression of SH3PXD2B mRNA

NCBI chr10:17,422,906...17,538,977
Ensembl chr10:17,422,947...17,512,854

G

SH3 and multiple ankyrin repeat domains 3

affects expression

EXP

Orphenadrine affects the expression of SHANK3 mRNA

NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:122,448,323...122,510,410

G

shisa family member 4

affects expression

EXP

Orphenadrine affects the expression of SHISA4 mRNA

NCBI chr13:49,351,518...49,355,599
Ensembl chr13:49,351,518...49,356,227

G

shroom family member 3

affects expression

EXP

Orphenadrine affects the expression of SHROOM3 mRNA

NCBI chr14:15,383,769...15,681,158
Ensembl chr14:15,383,769...15,680,462

G

SID1 transmembrane family, member 1

affects expression

EXP

Orphenadrine affects the expression of SIDT1 mRNA

NCBI chr11:69,867,758...69,965,377
Ensembl chr11:69,868,795...69,965,519

G

SIN3-HDAC complex associated factor

affects expression

EXP

Orphenadrine affects the expression of SINHCAF mRNA

NCBI chr 4:183,619,647...183,644,628
Ensembl chr 4:183,619,658...183,641,626

G

signal-induced proliferation-associated 1

affects expression

EXP

Orphenadrine affects the expression of SIPA1 mRNA

NCBI chr 1:212,367,867...212,379,952
Ensembl chr 1:212,367,867...212,377,497

G

SKI-like proto-oncogene

affects expression

EXP

Orphenadrine affects the expression of SKIL mRNA

NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:114,175,534...114,201,974

G

solute carrier family 12 member 4

affects expression

EXP

Orphenadrine affects the expression of SLC12A4 mRNA

NCBI chr19:50,748,268...50,770,217
Ensembl chr19:50,748,279...50,770,259

G

solute carrier family 16 member 10

affects expression

EXP

Orphenadrine affects the expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 16, member 11

affects expression

EXP

Orphenadrine affects the expression of SLC16A11 mRNA

NCBI chr10:55,427,773...55,431,678
Ensembl chr10:55,427,903...55,431,678

G

solute carrier family 16, member 14

affects expression

EXP

Orphenadrine affects the expression of SLC16A14 mRNA

NCBI chr 9:93,558,144...93,585,396
Ensembl chr 9:93,558,144...93,585,396

G

solute carrier family 16 member 5

affects expression

EXP

Orphenadrine affects the expression of SLC16A5 mRNA

NCBI chr10:101,206,371...101,220,300
Ensembl chr10:101,206,398...101,220,300

G

solute carrier family 16, member 6

affects expression

EXP

Orphenadrine affects the expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965

G

solute carrier family 1 member 4

affects expression

EXP

Orphenadrine affects the expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 22 member 2

multiple interactions

ISO

Orphenadrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Orphenadrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 30 member 2

affects expression

EXP

Orphenadrine affects the expression of SLC30A2 mRNA

NCBI chr 5:151,843,451...151,855,674
Ensembl chr 5:151,843,389...151,855,670

G

solute carrier family 35, member F2

affects expression

EXP

Orphenadrine affects the expression of SLC35F2 mRNA

NCBI chr 8:63,055,503...63,099,791
Ensembl chr 8:63,056,105...63,099,789

G

solute carrier family 41 member 1

affects expression

EXP

Orphenadrine affects the expression of SLC41A1 mRNA

NCBI chr13:45,822,999...45,843,364
Ensembl chr13:45,822,999...45,843,657

G

solute carrier family 6 member 8

affects expression

EXP

Orphenadrine affects the expression of SLC6A8 mRNA

NCBI chr X:156,536,017...156,545,321
Ensembl chr X:156,536,017...156,545,321

G

solute carrier family 7, member 4

affects expression

EXP

Orphenadrine affects the expression of SLC7A4 mRNA

NCBI chr11:96,939,456...96,943,127
Ensembl chr11:96,939,444...96,943,802

G

solute carrier family 9 member A7

affects expression

EXP

Orphenadrine affects the expression of SLC9A7 mRNA

NCBI chr X:4,767,578...4,948,602
Ensembl chr X:4,767,915...4,948,602

G

SMAD family member 6

affects expression

EXP

Orphenadrine affects the expression of SMAD6 mRNA

NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:73,345,460...73,414,149

G

smoothelin-like 2

affects expression

EXP

Orphenadrine affects the expression of SMTNL2 mRNA

NCBI chr10:57,506,873...57,528,050
Ensembl chr10:57,506,873...57,528,050

G

sorting nexin 10

affects expression

EXP

Orphenadrine affects the expression of SNX10 mRNA

NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:81,943,287...82,007,651

G

sortilin 1

affects expression

EXP

Orphenadrine affects the expression of SORT1 mRNA

NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481

G

SRY-box transcription factor 18

affects expression

EXP

Orphenadrine affects the expression of SOX18 mRNA

NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:189,163,002...189,164,802

G

SRY-box transcription factor 4

affects expression

EXP

Orphenadrine affects the expression of SOX4 mRNA

NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,875,756...35,884,024

G

SPC25 component of NDC80 kinetochore complex

affects expression

EXP

Orphenadrine affects the expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:74,383,548...74,396,718

G

Spetex-2C protein

affects expression

EXP

Orphenadrine affects the expression of SPETEX2C mRNA

NCBI chr15:5,323,242...5,326,382
Ensembl chr15:5,322,241...5,326,529
Ensembl chr15:5,322,241...5,326,529

G

Spetex-2F protein

affects expression

EXP

Orphenadrine affects the expression of SPETEX2F mRNA

NCBI chr15:5,457,458...5,460,606
Ensembl chr15:5,456,826...5,470,118
Ensembl chr15:5,456,826...5,470,118

G

Spetex-2G protein

affects expression

EXP

Orphenadrine affects the expression of SPETEX2G mRNA

NCBI chr15:5,929,946...5,933,558
Ensembl chr15:4,864,051...4,867,817
Ensembl chr15:4,864,051...4,867,817
Ensembl chr15:4,864,051...4,867,817

G

serine peptidase inhibitor, Kazal type 9

affects expression

EXP

Orphenadrine affects the expression of SPINK9 mRNA

NCBI chr18:36,677,935...36,681,163
Ensembl chr18:36,677,881...36,681,163

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

affects expression

EXP

Orphenadrine affects the expression of SPOCK2 mRNA

NCBI chr20:28,580,262...28,607,198
Ensembl chr20:28,580,226...28,608,409

G

SRC kinase signaling inhibitor 1

affects expression

EXP

Orphenadrine affects the expression of SRCIN1 mRNA

NCBI chr10:82,999,295...83,066,359
Ensembl chr10:82,991,033...83,067,419

G

steroid 5 alpha-reductase 1

affects expression

EXP

Orphenadrine affects the expression of SRD5A1 mRNA

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903

G

SH3 and cysteine rich domain 3

affects expression

EXP

Orphenadrine affects the expression of STAC3 mRNA

NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:65,228,352...65,235,878

G

StAR-related lipid transfer domain containing 9

affects expression

EXP

Orphenadrine affects the expression of STARD9 mRNA

NCBI chr 3:128,034,866...128,150,493
Ensembl chr 3:128,034,908...128,127,402

G

syntaxin binding protein 1

affects expression

EXP

Orphenadrine affects the expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058

G

sulfotransferase family 1E member 1

affects expression

EXP

Orphenadrine affects the expression of SULT1E1 mRNA

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

synapse defective Rho GTPase homolog 1

affects expression

EXP

Orphenadrine affects the expression of SYDE1 mRNA

NCBI chr 7:11,683,505...11,689,491
Ensembl chr 7:11,681,111...11,690,443

G

synaptic Ras GTPase activating protein 1

affects expression

EXP

Orphenadrine affects the expression of SYNGAP1 mRNA

NCBI chr20:5,028,226...5,058,519
Ensembl chr20:5,026,707...5,057,751

G

synaptojanin 2

affects expression

EXP

Orphenadrine affects the expression of SYNJ2 mRNA

NCBI chr 1:48,923,742...49,027,153
Ensembl chr 1:48,923,737...49,038,650

G

synemin

affects expression

EXP

Orphenadrine affects the expression of SYNM mRNA

NCBI chr 1:130,743,891...130,774,254
Ensembl chr 1:130,743,897...130,773,824

G

tubulin folding cofactor E-like

affects expression

EXP

Orphenadrine affects the expression of TBCEL mRNA

NCBI chr 8:51,692,660...51,751,560
Ensembl chr 8:51,694,930...51,751,560

G

TEA domain transcription factor 2

affects expression

EXP

Orphenadrine affects the expression of TEAD2 mRNA

NCBI chr 1:104,838,795...104,855,635
Ensembl chr 1:104,838,623...104,855,630

G

teneurin transmembrane protein 2

affects expression

EXP

Orphenadrine affects the expression of TENM2 mRNA

NCBI chr10:20,984,710...22,121,001
Ensembl chr10:20,985,902...22,447,611

G

testis expressed 13B

affects expression

EXP

Orphenadrine affects the expression of TEX13B mRNA

NCBI chr X:109,278,123...109,299,718
Ensembl chr X:109,279,874...109,282,878

G

testis expressed 36

affects expression

EXP

Orphenadrine affects the expression of TEX36 mRNA

NCBI chr 1:197,820,066...197,834,473
Ensembl chr 1:197,820,068...197,834,380

G

thioesterase superfamily member 6

affects expression

EXP

Orphenadrine affects the expression of THEM6 mRNA

NCBI chr 7:108,495,554...108,498,731
Ensembl chr 7:108,495,569...108,498,904

G

TRAF-interacting protein with forkhead-associated domain

affects expression

EXP

Orphenadrine affects the expression of TIFA mRNA

NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:218,909,915...218,956,224

G

TLC domain containing 4

affects expression

EXP

Orphenadrine affects the expression of TLCD4 mRNA

NCBI chr 2:211,969,612...212,044,883
Ensembl chr 2:211,974,471...212,026,081

G

talin rod domain containing 1

affects expression

EXP

Orphenadrine affects the expression of TLNRD1 mRNA

NCBI chr 1:147,273,475...147,275,494
Ensembl chr 1:147,178,456...147,283,303

G

transmembrane BAX inhibitor motif containing 1

affects expression

EXP

Orphenadrine affects the expression of TMBIM1 mRNA

NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:83,320,979...83,338,657

G

transmembrane protein 184B

affects expression

EXP

Orphenadrine affects the expression of TMEM184B mRNA

NCBI chr 7:112,805,512...112,848,398
Ensembl chr 7:112,805,512...112,848,351

G

transmembrane protein 184C

affects expression

EXP

Orphenadrine affects the expression of TMEM184C mRNA

NCBI chr19:47,249,403...47,265,502
Ensembl chr19:47,249,500...47,265,949

G

transmembrane protein 200B

affects expression

EXP

Orphenadrine affects the expression of TMEM200B mRNA

NCBI chr 5:149,391,865...149,394,621
Ensembl chr 5:149,387,441...149,409,282

G

TNF alpha induced protein 2

affects expression

EXP

Orphenadrine affects the expression of TNFAIP2 mRNA

NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:136,298,082...136,311,106

G

TNF receptor superfamily member 11B

affects expression

EXP

Orphenadrine affects the expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 12A

affects expression

EXP

Orphenadrine affects the expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

tyrosine kinase, non-receptor, 1

affects expression

EXP

Orphenadrine affects the expression of TNK1 mRNA

NCBI chr10:55,070,362...55,084,383
Ensembl chr10:55,069,837...55,078,710

G

tensin 1

affects expression

EXP

Orphenadrine affects the expression of TNS1 mRNA

NCBI chr 9:82,941,068...83,152,007
Ensembl chr 9:82,941,068...83,152,007

G

TOG array regulator of axonemal microtubules 2

affects expression

EXP

Orphenadrine affects the expression of TOGARAM2 mRNA

NCBI chr 6:29,491,183...29,549,004
Ensembl chr 6:29,491,040...29,548,977

G

TOX high mobility group box family member 3

affects expression

EXP

Orphenadrine affects the expression of TOX3 mRNA

NCBI chr19:32,820,957...32,929,776
Ensembl chr19:32,820,977...32,929,776

G

tropomyosin 1

affects expression

EXP

Orphenadrine affects the expression of TPM1 mRNA

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468

G

Tnf receptor associated factor 4

affects expression

EXP

Orphenadrine affects the expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,552,253...63,558,356

G

tripartite motif-containing 36

affects expression

EXP

Orphenadrine affects the expression of TRIM36 mRNA

NCBI chr18:41,047,657...41,099,497
Ensembl chr18:41,047,657...41,104,704

G

tripartite motif-containing 54

affects expression

EXP

Orphenadrine affects the expression of TRIM54 mRNA

NCBI chr 6:30,959,306...30,978,475
Ensembl chr 6:30,959,306...30,978,475

G

transient receptor potential cation channel, subfamily M, member 2

affects expression

EXP

Orphenadrine affects the expression of TRPM2 mRNA

NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,704,482...10,752,802

G

transient receptor potential cation channel, subfamily V, member 2

affects expression

EXP

Orphenadrine affects the expression of TRPV2 mRNA

NCBI chr10:47,772,223...47,797,956
Ensembl chr10:47,764,839...47,793,533

G

TSC22 domain family, member 3

affects expression

EXP

Orphenadrine affects the expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

alpha tocopherol transfer protein like

affects expression

EXP

Orphenadrine affects the expression of TTPAL mRNA

NCBI chr 3:172,697,683...172,715,973
Ensembl chr 3:172,697,729...172,715,983

G

tubulin, alpha 3A

affects expression

EXP

Orphenadrine affects the expression of TUBA3A mRNA

NCBI chr 4:159,761,311...159,770,200
Ensembl chr 4:159,761,311...159,770,200

G

ubiquitin-like modifier activating enzyme 7

affects expression

EXP

Orphenadrine affects the expression of UBA7 mRNA

NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:117,543,957...117,556,142

G

UDP glucuronosyltransferase family 2 member A3

affects expression

EXP

Orphenadrine affects the expression of UGT2A3 mRNA

NCBI chr14:20,851,970...20,869,974
Ensembl chr14:20,851,969...20,869,973

G

UDP glucuronosyltransferase 2 family, polypeptide B1

affects expression

EXP

Orphenadrine affects the expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

unc-5 netrin receptor B

affects expression

EXP

Orphenadrine affects the expression of UNC5B mRNA

NCBI chr20:29,240,639...29,307,270
Ensembl chr20:29,240,650...29,307,270

G

unk like zinc finger

affects expression

EXP

Orphenadrine affects the expression of UNKL mRNA

NCBI chr10:14,710,627...14,756,725
Ensembl chr10:14,710,563...14,756,724

G

uridine phosphorylase 2

affects expression

EXP

Orphenadrine affects the expression of UPP2 mRNA

NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:63,681,826...63,726,191

G

ubiquitin specific peptidase 18

affects expression

EXP

Orphenadrine affects the expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:156,143,815...156,171,292

G

integral membrane transport protein UST4r

affects expression

EXP

Orphenadrine affects the expression of UST4R mRNA

NCBI chr 1:214,501,347...214,571,852
Ensembl chr 1:214,501,347...214,571,832

G

vav guanine nucleotide exchange factor 2

affects expression

EXP

Orphenadrine affects the expression of VAV2 mRNA

NCBI chr 3:30,982,754...31,152,116
Ensembl chr 3:30,982,754...31,152,116

G

vasoactive intestinal peptide receptor 1

affects expression

EXP

Orphenadrine affects the expression of VIPR1 mRNA

NCBI chr 8:130,181,219...130,217,098
Ensembl chr 8:130,187,731...130,217,096

G

vanin 1

affects expression

EXP

Orphenadrine affects the expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

vomeronasal 2 receptor, 3

affects expression

EXP

Orphenadrine affects the expression of VOM2R3 mRNA

NCBI chr 1:2,759,624...2,768,498

G

WAP four-disulfide core domain 1

affects expression

EXP

Orphenadrine affects the expression of WFDC1 mRNA

NCBI chr19:64,628,689...64,647,739
Ensembl chr19:64,607,794...64,648,028

G

WAS/WASL interacting protein family, member 3

affects expression

EXP

Orphenadrine affects the expression of WIPF3 mRNA

NCBI chr 4:84,880,403...84,960,250
Ensembl chr 4:84,880,740...84,961,524

G

X-prolyl aminopeptidase 2

affects expression

EXP

Orphenadrine affects the expression of XPNPEP2 mRNA

NCBI chr X:132,165,696...132,194,937
Ensembl chr X:132,165,701...132,195,126

G

zinc finger and BTB domain containing 10

affects expression

EXP

Orphenadrine affects the expression of ZBTB10 mRNA

NCBI chr 2:94,382,670...94,417,308
Ensembl chr 2:94,386,400...94,417,308

G

zinc finger and BTB domain containing 42

affects expression

EXP

Orphenadrine affects the expression of ZBTB42 mRNA

NCBI chr 6:137,559,622...137,561,750
Ensembl chr 6:137,555,304...137,570,261

G

zinc finger, C2HC-type containing 1A

affects expression

EXP

Orphenadrine affects the expression of ZC2HC1A mRNA

NCBI chr 2:96,194,665...96,231,957
Ensembl chr 2:96,194,671...96,232,288

G

zinc finger DHHC-type palmitoyltransferase 8

affects expression

EXP

Orphenadrine affects the expression of ZDHHC8 mRNA

NCBI chr11:96,259,383...96,273,588
Ensembl chr11:96,259,449...96,284,003

G

zinc finger protein 319

affects expression

EXP

Orphenadrine affects the expression of ZFP319 mRNA

NCBI chr19:9,708,881...9,712,860
Ensembl chr19:9,707,983...9,728,711

G

zinc finger protein 334

affects expression

EXP

Orphenadrine affects the expression of ZFP334 mRNA

NCBI chr 3:174,531,835...174,544,374
Ensembl chr 3:174,533,517...174,544,400

G

zinc finger protein 354A

affects expression

EXP

Orphenadrine affects the expression of ZFP354A mRNA

NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,897,228...35,909,510

G

zinc finger protein 36

affects expression

EXP

Orphenadrine affects the expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 36, C3H type-like 2

affects expression

EXP

Orphenadrine affects the expression of ZFP36L2 mRNA

NCBI chr 6:16,242,622...16,246,662
Ensembl chr 6:16,242,610...16,246,653

G

zinc finger protein 503

affects expression

EXP

Orphenadrine affects the expression of ZFP503 mRNA

NCBI chr15:2,362,450...2,366,238
Ensembl chr15:2,362,427...2,366,238

G

zinc finger protein 668

affects expression

EXP

Orphenadrine affects the expression of ZFP668 mRNA

NCBI chr 1:191,905,112...191,915,436
Ensembl chr 1:191,905,112...191,914,997

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

oxybutynin results in decreased activity of ABCB11 protein

PMID:20829430 PMID:28437613

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

oxybutynin results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

C-C motif chemokine ligand 2

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

carboxylesterase 2H

increases hydrolysis

ISO

CES2 protein results in increased hydrolysis of oxybutynin

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

oxybutynin binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions

ISO

oxybutynin binds to and results in decreased activity of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

ISO

oxybutynin results in decreased activity of CYP2C8 protein

G

dopamine receptor D2

affects binding

ISO

oxybutynin binds to DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

interleukin 1 beta

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

decreases expression

ISO

oxybutynin results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 6

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

oxybutynin results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

ISO

oxybutynin results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

matrix metallopeptidase 2

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

nitric oxide synthase 2

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 22 member 2

multiple interactions

ISO

oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

oxybutynin results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

toll-like receptor 4

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arginine vasopressin receptor 1A

multiple interactions

EXP

Pirenzepine binds to and results in decreased activity of AVPR1A protein

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:59,999,738...60,003,837

G

CD40 molecule

multiple interactions

ISO

Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

cholinergic receptor, muscarinic 1

multiple interactions
affects binding

ISO
EXP

brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]
Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]

PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 More...

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 5

multiple interactions

ISO

Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

early growth response 1

multiple interactions

EXP

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

multiple interactions

EXP

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Pizotyline results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Procyclidine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

bone morphogenetic protein 6

increases expression

ISO

Procyclidine results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

epiregulin

increases expression

ISO

Procyclidine results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

interleukin 1 alpha

increases expression

ISO

Procyclidine results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression

ISO

Procyclidine results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

Procyclidine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Procyclidine results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Procyclidine results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

Procyclidine results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 22 member 2

multiple interactions

ISO

Procyclidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 7 member 11

increases expression

ISO

Procyclidine results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Procyclidine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

TNF alpha induced protein 6

increases expression

ISO

Procyclidine results in increased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity
multiple interactions

ISO

profenamine results in decreased activity of BCHE protein
profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]

PMID:18656440 PMID:22407886 PMID:28299395 PMID:32278739 PMID:32795450

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

profenamine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

ISO

Promazine results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

corticotropin releasing hormone

decreases expression

ISO

Promazine results in decreased expression of CRH mRNA

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Promazine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

solute carrier family 22 member 2

multiple interactions

ISO

Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport
affects response to substance
decreases expression
affects transport
affects binding
multiple interactions

ISO

ABCB1 protein results in increased transport of Quinidine
ABCB1A protein affects the susceptibility to Quinidine
Quinidine results in decreased expression of ABCB1 protein
ABCB1 protein affects the transport of Quinidine
Quinidine binds to ABCB1 protein
methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]

PMID:15502009 PMID:15616150 PMID:20196146 PMID:23976943 PMID:26995013

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

affects response to substance
affects activity

ISO
EXP

ABCB1B protein affects the susceptibility to Quinidine
Quinidine affects the activity of ABCB1B protein

PMID:12626638 PMID:15502009

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

acyl-CoA dehydrogenase medium chain

decreases expression

EXP

Quinidine results in decreased expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

angiotensin converting enzyme 2

decreases expression

ISO

Quinidine results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

adrenoceptor alpha 1A

affects binding
multiple interactions

ISO

Quinidine binds to ADRA1A protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

affects binding
multiple interactions

ISO

Quinidine binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

affects binding
multiple interactions

ISO

Quinidine binds to ADRA1D protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]

NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:139,246,323...139,262,331

G

aldolase, fructose-bisphosphate A

increases expression

EXP

Quinidine results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Quinidine results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

catalase

increases expression

ISO

Quinidine results in increased expression of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Quinidine results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CEA cell adhesion molecule 1

increases expression

EXP

Quinidine results in increased expression of CEACAM1 mRNA

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

cytochrome b5 reductase 3

decreases expression

EXP

Quinidine results in decreased expression of CYB5R3 mRNA

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

ISO

Quinidine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Quinidine results in decreased activity of CYP1A1 protein

PMID:18420780 PMID:18493746

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO

Quinidine affects the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP1A2 protein

PMID:15916432 PMID:19053182

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

Quinidine results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity

ISO

Quinidine results in decreased activity of CYP2A4 protein

NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity

ISO

Quinidine results in decreased activity of CYP2B10 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity
multiple interactions

EXP
ISO

Quinidine results in decreased activity of CYP2C6 protein
Quinidine results in decreased activity of CYP2C29 protein
Quinidine affects the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]

PMID:12814958 PMID:18420780 PMID:19053182

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

EXP

Quinidine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
decreases activity
multiple interactions

ISO
EXP

CYP2D6 protein results in increased metabolism of Quinidine
Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride
Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine affects the reaction [CYP2D6 protein polymorphism affects the metabolism of dacomitinib]; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]

PMID:8819299 PMID:11377097 PMID:11560869 PMID:11673748 PMID:12464242 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

Quinidine results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects metabolic processing

ISO

Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the metabolism of Quinidine

PMID:2271712 PMID:15784650 PMID:19230594 PMID:19299527

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DEPP autophagy regulator 1

increases expression

ISO

Quinidine results in increased expression of DEPP1 mRNA

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233

G

fatty acid binding protein 1

increases expression

ISO

Quinidine results in increased expression of FABP1 mRNA

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

fibrinogen alpha chain

increases expression

EXP

Quinidine results in increased expression of FGA mRNA

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577

G

fibrinogen beta chain

increases expression

EXP

Quinidine results in increased expression of FGB mRNA

NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434

G

glutathione S-transferase mu 1

decreases activity

ISO

Quinidine results in decreased activity of GSTM1 protein

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase, mu 5

decreases expression

EXP

Quinidine results in decreased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase pi 1

multiple interactions
decreases activity

ISO

Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinidine results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

3-hydroxyisobutyrate dehydrogenase

increases expression

EXP

Quinidine results in increased expression of HIBADH mRNA

NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:82,979,765...83,111,242

G

insulin-like growth factor 1

multiple interactions

ISO

Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

inhibin subunit beta E

increases expression

ISO

Quinidine results in increased expression of INHBE mRNA

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

potassium voltage-gated channel subfamily H member 1

multiple interactions

ISO

Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

NCBI chr13:106,253,101...106,555,712
Ensembl chr13:106,253,213...106,555,710

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity
affects activity
affects binding
affects localization
affects response to substance
decreases response to substance

ISO

[Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]
Quinidine affects the activity of KCNH2 protein
Quinidine binds to KCNH2 protein
Quinidine affects the localization of KCNH2 protein mutant form
KCNH2 gene SNP affects the susceptibility to Quinidine
KCNH2 gene mutant form results in decreased susceptibility to Quinidine

PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 More...

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium two pore domain channel subfamily K member 1

multiple interactions

ISO

Quinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]; Quinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium]

NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051

G

potassium two pore domain channel subfamily K member 18

multiple interactions

ISO

Quinidine inhibits the reaction [KCNK18 protein results in increased transport of Potassium]

NCBI chr 1:268,360,738...268,375,012
Ensembl chr 1:268,360,738...268,375,012

G

potassium two pore domain channel subfamily K member 9

multiple interactions

EXP

Quinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]

NCBI chr 7:106,316,783...106,362,452
Ensembl chr 7:106,326,684...106,361,921

G

lipopolysaccharide binding protein

increases expression

EXP

Quinidine results in increased expression of LBP mRNA

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518

G

lipase C, hepatic type

decreases expression

EXP

Quinidine results in decreased expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

EXP

Quinidine results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nuclear protein 1, transcriptional regulator

increases expression

ISO

Quinidine results in increased expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

ornithine transcarbamylase

decreases expression

EXP

Quinidine results in decreased expression of OTC mRNA

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555

G

pyruvate kinase L/R

decreases expression

EXP

Quinidine results in decreased expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

prothymosin alpha

decreases expression

EXP

Quinidine results in decreased expression of PTMA mRNA

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276

G

S100 calcium binding protein A9

increases expression

EXP

Quinidine results in increased expression of S100A9 mRNA

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

sodium voltage-gated channel alpha subunit 5

affects response to substance

ISO

SCN5A gene mutant form affects the susceptibility to Quinidine

NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470

G

solute carrier family 22 member 1

multiple interactions

EXP
ISO

[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]

PMID:16141367 PMID:21140131 PMID:23831208 PMID:24799337 PMID:24947867

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:16141367 PMID:21599003

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions

ISO

Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 2 member 3

decreases expression

ISO

Quinidine results in decreased expression of SLC2A3 mRNA

PMID:15342952 PMID:17567588

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 47 member 1

decreases activity
multiple interactions

ISO

Quinidine results in decreased activity of SLC47A1 protein
Quinidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16928787 PMID:22419765

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

solute carrier organic anion transporter family, member 1a1

decreases activity
multiple interactions

EXP

Quinidine results in decreased activity of SLCO1A1 protein
Quinidine inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992

G

transgelin

decreases expression

ISO

Quinidine results in decreased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

TIMP metallopeptidase inhibitor 1

increases expression

EXP

Quinidine results in increased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TNF receptor superfamily member 1A

decreases expression

EXP

Quinidine results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 8

decreases expression

ISO

Quinidine results in decreased expression of TNFRSF8 protein

NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620

G

tumor protein p53

decreases expression

EXP

Quinidine results in decreased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

EXP

Scopolamine results in decreased expression of ABCB1 mRNA

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily G member 1

increases expression

EXP

Scopolamine results in increased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

acetylcholinesterase

multiple interactions
increases expression
affects activity
increases activity
decreases activity
decreases expression
affects response to substance
increases response to substance

ISO
EXP

kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
Scopolamine affects the activity of ACHE protein
Scopolamine results in decreased activity of ACHE protein
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in decreased expression of ACHE protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; polygalacic acid inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ACHE affects the susceptibility to Scopolamine
ACHE protein results in increased susceptibility to Scopolamine

PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adenosine A3 receptor

multiple interactions

ISO

[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 2:196,077,042...196,080,686
Ensembl chr 2:196,077,042...196,080,686

G

angiotensinogen

multiple interactions

ISO

[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

AKT serine/threonine kinase 1

decreases phosphorylation

EXP

Scopolamine results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

amyloid beta precursor protein binding family A member 1

increases expression

EXP

Scopolamine results in increased expression of APBA1 mRNA

NCBI chr 1:230,790,297...230,995,986
Ensembl chr 1:230,790,297...230,995,986

G

amyloid beta precursor like protein 2

increases expression

EXP

Scopolamine results in increased expression of APLP2 mRNA

NCBI chr 8:37,857,407...37,920,487
Ensembl chr 8:37,857,407...37,920,031

G

amyloid beta precursor protein

decreases cleavage

ISO

Scopolamine results in decreased cleavage of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

activity-regulated cytoskeleton-associated protein

decreases expression
decreases expression

EXP
ISO

Scopolamine results in decreased expression of ARC mRNA
scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus

CTD
RGD

PMID:17540011 PMID:24012642

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

arginase 2

decreases expression

EXP

Scopolamine results in decreased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375

G

ARF like GTPase 4D

decreases expression

EXP

Scopolamine results in decreased expression of ARL4D mRNA

NCBI chr10:87,092,276...87,103,079
Ensembl chr10:87,077,523...87,106,199

G

arginine vasopressin

multiple interactions

EXP

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

arginine vasopressin receptor 1A

multiple interactions

EXP

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:59,999,738...60,003,837

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO
EXP

Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
Galantamine inhibits the reaction [Scopolamine results in increased expression of BAX protein]; intybin inhibits the reaction [Scopolamine results in increased expression of BAX protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]

PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

branched chain amino acid transaminase 1

increases expression

EXP

Scopolamine results in increased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein
Galantamine inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]

PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

EXP
ISO

Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]

PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 More...

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

calcium voltage-gated channel subunit alpha1 D

increases expression

EXP

Scopolamine results in increased expression of CACNA1D mRNA

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

EXP

Scopolamine results in decreased expression of CAMKK2 mRNA

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964

G

CART prepropeptide

decreases expression

EXP

Scopolamine results in decreased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712

G

caspase 3

increases expression
increases cleavage
multiple interactions
increases activity

ISO
EXP

Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
Scopolamine results in increased cleavage of CASP3 protein
Galantamine inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]; intybin inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]
Scopolamine results in increased activity of CASP3 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]

PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions
decreases activity
increases activity

ISO
EXP

acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]
Galantamine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; intybin inhibits the reaction [Scopolamine results in decreased activity of CAT protein]

PMID:20673844 PMID:27346436 PMID:27717698 PMID:31077737 PMID:34371027

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

CD3 epsilon subunit of T-cell receptor complex

decreases expression

EXP

Scopolamine results in decreased expression of CD3E mRNA

NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:54,200,617...54,211,876

G

cyclin-dependent kinase-like 4

increases expression

EXP

Scopolamine results in increased expression of CDKL4 mRNA

NCBI chr 6:20,202,047...20,244,821
Ensembl chr 6:20,217,916...20,244,002

G

choline O-acetyltransferase

decreases activity
multiple interactions

ISO

Scopolamine results in decreased activity of CHAT protein
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]

PMID:20694781 PMID:26408985 PMID:29133030

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

cholinergic receptor, muscarinic 1

multiple interactions
decreases expression
increases expression

EXP
ISO

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Scopolamine results in increased expression of CHRM1 mRNA
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]

PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 4

increases response to substance

ISO

CHRM4 protein results in increased susceptibility to Scopolamine

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

cholinergic receptor, muscarinic 5

decreases response to substance

ISO

CHRM5 protein results in decreased susceptibility to Scopolamine

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

cholinergic receptor nicotinic alpha 4 subunit

affects binding
multiple interactions

ISO

Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

ISO

Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

cochlin

decreases expression

EXP

Scopolamine results in decreased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502

G

coronin 1B

increases expression

EXP

Scopolamine results in increased expression of CORO1B mRNA

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:210,871,841...210,877,876

G

cytochrome c oxidase subunit 5B

increases expression

EXP

Scopolamine results in increased expression of COX5B mRNA

NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:46,417,838...46,420,403

G

cAMP responsive element binding protein 1

decreases phosphorylation
multiple interactions

ISO

Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]

PMID:26408985 PMID:31077737

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

crystallin, alpha B

increases expression

EXP

Scopolamine results in increased expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

colony stimulating factor 2

multiple interactions
decreases response to substance

ISO

IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

C-X-C motif chemokine receptor 5

decreases expression

EXP

Scopolamine results in decreased expression of CXCR5 mRNA

NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:53,740,197...53,754,816

G

dopa decarboxylase

decreases expression

EXP

Scopolamine results in decreased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

deoxyguanosine kinase

increases expression

EXP

Scopolamine results in increased expression of DGUOK mRNA

NCBI chr 4:117,544,784...117,572,414
Ensembl chr 4:117,544,773...117,572,414

G

iodothyronine deiodinase 2

increases expression

EXP

Scopolamine results in increased expression of DIO2 mRNA

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

dual specificity phosphatase 5

decreases expression

EXP

Scopolamine results in decreased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 6

decreases expression

EXP

Scopolamine results in decreased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

epidermal growth factor receptor

decreases expression

EXP

Scopolamine results in decreased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions
decreases expression

EXP
ISO

[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
Scopolamine results in decreased expression of EGR1 mRNA

PMID:8861055 PMID:17540011 PMID:29133030

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

decreases expression

EXP

Scopolamine results in decreased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

EXP

Scopolamine results in increased expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

EMAP like 1

decreases expression

EXP

Scopolamine results in decreased expression of EML1 mRNA

NCBI chr 6:133,048,271...133,221,642
Ensembl chr 6:133,048,427...133,221,642

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

EXP
ISO

[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
Scopolamine results in decreased expression of FOS mRNA

PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

gamma-aminobutyric acid type B receptor subunit 1

increases expression

EXP

Scopolamine results in increased expression of GABBR1 mRNA

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,469,779...1,498,607

G

growth associated protein 43

decreases expression
multiple interactions

ISO

Scopolamine results in decreased expression of GAP43 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

glial fibrillary acidic protein

multiple interactions
decreases expression

ISO

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

gap junction protein, beta 2

increases expression

EXP

Scopolamine results in increased expression of GJB2 mRNA

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877

G

glypican 3

decreases expression

EXP

Scopolamine results in decreased expression of GPC3 mRNA

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

glutamate metabotropic receptor 4

multiple interactions

ISO

Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,482,977...5,574,668

G

glutathione-disulfide reductase

decreases activity
multiple interactions

ISO

Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glycophorin C

decreases expression

EXP

Scopolamine results in decreased expression of GYPC mRNA

NCBI chr18:24,434,921...24,467,592
Ensembl chr18:24,434,922...24,440,053

G

heme oxygenase 1

multiple interactions
increases expression

ISO

7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

homer scaffold protein 1

decreases expression

EXP

Scopolamine results in decreased expression of HOMER1 mRNA

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

histamine receptor H 1

multiple interactions

EXP

[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H 2

multiple interactions

EXP

[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]

PMID:11640976 PMID:19215234

NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041

G

histamine receptor H3

multiple interactions

EXP

[clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259

G

heat shock protein family A (Hsp70) member 2

increases expression

EXP

Scopolamine results in increased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

5-hydroxytryptamine receptor 1A

multiple interactions
increases expression

EXP

[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine]
Scopolamine increases expression of Htr1a mRNA in amygdala, hippocampal formation; Scopolamine increases expression of Htr1a protein in amygdala, hippocampal formation

CTD
RGD

PMID:10578133 PMID:27760517

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 2C

increases expression

EXP

Scopolamine results in increased expression of HTR2C mRNA

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:115,452,842...115,682,324

G

5-hydroxytryptamine receptor 6

decreases expression

EXP

Scopolamine results in decreased expression of HTR6 mRNA

NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147

G

interferon gamma

multiple interactions
increases expression

EXP

Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

decreases expression
multiple interactions

ISO

Scopolamine results in decreased expression of IL10 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; polygalacic acid inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]

PMID:26926176 PMID:31077737

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 alpha

decreases response to substance

ISO

IL1A protein results in decreased susceptibility to Scopolamine

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression
multiple interactions

ISO
EXP

Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; polygalacic acid inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]

PMID:18357464 PMID:19426756 PMID:21161262 PMID:26926176 PMID:31077737

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor antagonist

multiple interactions

ISO

IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 6

multiple interactions
increases expression

EXP
ISO

Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein

PMID:18357464 PMID:21161262 PMID:31077737

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression

EXP

Scopolamine results in increased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

EXP
ISO

Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Scopolamine results in decreased expression of JUN protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]

PMID:11337201 PMID:29133030

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Scopolamine results in decreased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

potassium voltage-gated channel subfamily A member 4

increases expression

EXP

Scopolamine results in increased expression of KCNA4 mRNA

NCBI chr 3:114,211,091...114,218,545
Ensembl chr 3:114,210,998...114,344,932

G

potassium voltage-gated channel subfamily B member 1

increases expression

EXP

Scopolamine results in increased expression of KCNB1 mRNA

PMID:12579815 PMID:15567561

NCBI chr 3:176,239,285...176,332,408
Ensembl chr 3:176,242,589...176,332,408

G

potassium voltage-gated channel subfamily D member 2

decreases expression

EXP

Scopolamine results in decreased expression of KCND2 mRNA

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

ISO

Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104

G

KLF transcription factor 2

decreases expression

EXP

Scopolamine results in decreased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768

G

KLF transcription factor 4

decreases expression

EXP

Scopolamine results in decreased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

leucyl and cystinyl aminopeptidase

multiple interactions

ISO

[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine

NCBI chr 1:66,931,712...67,027,610
Ensembl chr 1:66,931,712...67,027,610

G

MAP-kinase activating death domain

increases expression

EXP

Scopolamine results in increased expression of MADD mRNA

NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:97,570,787...97,613,509

G

microtubule-associated protein 2

decreases expression
multiple interactions

ISO

Scopolamine results in decreased expression of MAP2 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

microtubule-associated protein tau

decreases expression

EXP

Scopolamine results in decreased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

myelin basic protein

decreases expression
multiple interactions

ISO

Scopolamine results in decreased expression of MBP protein
Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

mucin 5AC, oligomeric mucus/gel-forming

decreases expression

ISO
EXP

Scopolamine results in decreased expression of MUC5AC protein

PMID:18357464 PMID:21161262

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

neurofilament heavy chain

multiple interactions
decreases expression

ISO

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

ISO
EXP

7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
Galantamine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]

PMID:27346436 PMID:32001261

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nerve growth factor

decreases response to substance
decreases secretion
multiple interactions
increases response to substance

EXP
ISO

NGF protein results in decreased susceptibility to Scopolamine
Scopolamine results in decreased secretion of NGF protein
Galantamine promotes the reaction [Scopolamine results in decreased secretion of NGF protein]; intybin inhibits the reaction [Scopolamine results in decreased secretion of NGF protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
NGF protein results in increased susceptibility to Scopolamine

PMID:1661212 PMID:8635431 PMID:16405025 PMID:27346436

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nitric oxide synthase 2

multiple interactions
increases expression

ISO

acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]

PMID:26408985 PMID:31077737

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NOVA alternative splicing regulator 1

multiple interactions

EXP

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]

NCBI chr 6:69,506,983...69,632,437
Ensembl chr 6:69,506,983...69,632,437

G

NOVA alternative splicing regulator 2

multiple interactions

EXP

Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]

NCBI chr 1:87,700,328...87,741,755
Ensembl chr 1:87,700,328...87,778,669

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
decreases expression

ISO

Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

increases expression

EXP

Scopolamine results in increased expression of NQO2 mRNA

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 1, group D, member 1

decreases expression

EXP

Scopolamine results in decreased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

EXP

Scopolamine results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

neurotrophin 3

multiple interactions

EXP

Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
decreases expression

EXP
ISO

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
Scopolamine results in decreased expression of NTRK2 protein
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]

PMID:8635431 PMID:29476728 PMID:31077737

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

neurotrophic receptor tyrosine kinase 3

multiple interactions

EXP

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]

NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004

G

programmed cell death 4

increases expression

EXP

Scopolamine results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

prodynorphin

decreases response to substance
multiple interactions
increases expression

ISO
EXP

PDYN protein modified form results in decreased susceptibility to Scopolamine
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
Scopolamine results in increased expression of PDYN mRNA

PMID:7768285 PMID:17540011

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

proenkephalin

multiple interactions

EXP

Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705

G

phosphoglycerate mutase 1

decreases expression

EXP

Scopolamine results in decreased expression of PGAM1 mRNA

NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203

G

prolyl endopeptidase

increases response to substance
increases expression
multiple interactions

EXP

PREP protein results in increased susceptibility to Scopolamine
Scopolamine results in increased expression of PREP protein
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]

PMID:17244263 PMID:18318186

NCBI chr20:50,138,588...50,235,549
Ensembl chr20:50,131,819...50,252,697

G

protein activator of interferon induced protein kinase EIF2AK2

decreases expression

EXP

Scopolamine results in decreased expression of PRKRA mRNA

NCBI chr 3:81,982,669...82,002,028
Ensembl chr 3:81,982,673...82,001,525

G

presenilin 2

decreases expression

EXP

Scopolamine results in decreased expression of PSEN2 mRNA

NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

ISO

Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]

PMID:26408985 PMID:31077737

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RAB14, member RAS oncogene family

increases expression

EXP

Scopolamine results in increased expression of RAB14 mRNA

NCBI chr 3:38,899,430...38,920,572
Ensembl chr 3:38,901,400...38,912,273

G

Rap guanine nucleotide exchange factor 3

decreases expression

EXP

Scopolamine results in decreased expression of RAPGEF3 mRNA

NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]

PMID:19182383 PMID:19426756

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RRAD and GEM like GTPase 2

decreases expression

EXP

Scopolamine results in decreased expression of REM2 mRNA

NCBI chr15:31,903,972...31,908,451
Ensembl chr15:31,903,965...31,908,445

G

regulator of G-protein signaling 7 binding protein

decreases expression

EXP

Scopolamine results in decreased expression of RGS7BP mRNA

NCBI chr 2:37,867,698...37,965,587
Ensembl chr 2:37,872,949...37,965,253

G

roundabout guidance receptor 3

decreases expression

EXP

Scopolamine results in decreased expression of ROBO3 mRNA

NCBI chr 8:45,322,323...45,340,466
Ensembl chr 8:45,323,344...45,340,222

G

Ras-related GTP binding A

increases expression

EXP

Scopolamine results in increased expression of RRAGA mRNA

NCBI chr 5:106,159,335...106,160,930
Ensembl chr 5:106,158,853...106,160,504

G

S100 calcium-binding protein A4

decreases expression

EXP

Scopolamine results in decreased expression of S100A4 mRNA

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837

G

sphingosine-1-phosphate receptor 1

increases expression

EXP

Scopolamine results in increased expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689

G

secretory carrier membrane protein 2

increases expression

EXP

Scopolamine results in increased expression of SCAMP2 mRNA

NCBI chr 8:66,861,504...66,888,151
Ensembl chr 8:66,861,537...66,888,150

G

sigma non-opioid intracellular receptor 1

multiple interactions

ISO

[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855

G

solute carrier family 47 member 1

multiple interactions

ISO

Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

sulfotransferase family 1A member 1

increases expression

EXP

Scopolamine results in increased expression of SULT1A1 mRNA

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

synaptophysin

multiple interactions
decreases expression
increases expression

EXP
ISO

cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]

PMID:20188767 PMID:34371027

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

tachykinin, precursor 1

decreases response to substance

EXP

TAC1 protein modified form results in decreased susceptibility to Scopolamine

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

tumor necrosis factor

multiple interactions
increases expression

ISO
EXP

acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein

PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

trinucleotide repeat containing adaptor 6A

decreases expression

EXP

Scopolamine results in decreased expression of TNRC6A mRNA

NCBI chr 1:186,992,457...187,146,764
Ensembl chr 1:186,992,504...187,146,756

G

TPD52 like 1

increases expression

EXP

Scopolamine results in increased expression of TPD52L1 mRNA

NCBI chr 1:27,991,114...28,109,767
Ensembl chr 1:27,991,131...28,110,158

G

VGF nerve growth factor inducible

decreases expression

EXP

Scopolamine results in decreased expression of VGF mRNA

NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703

G

vasoactive intestinal peptide

decreases response to substance

EXP

VIP protein results in decreased susceptibility to Scopolamine

NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558

thiethylperazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

amyloid beta precursor protein

multiple interactions

ISO

[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

tiotropium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 1

affects binding

ISO

Tiotropium Bromide binds to CHRM1 protein

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 2

affects binding

ISO

Tiotropium Bromide binds to CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

affects binding

ISO

Tiotropium Bromide binds to CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor, muscarinic 4

affects binding

ISO

Tiotropium Bromide binds to CHRM4 protein

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

cholinergic receptor, muscarinic 5

affects binding

ISO

Tiotropium Bromide binds to CHRM5 protein

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166

G

endothelin 1

multiple interactions

ISO

Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

paraoxonase 1

decreases activity

ISO

Tiotropium Bromide results in decreased activity of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

tumor necrosis factor

decreases secretion

ISO

Tiotropium Bromide results in decreased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

tiquizium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

thiaton results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

myeloperoxidase

multiple interactions

EXP

thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

nitric oxide synthase 2

multiple interactions

EXP

thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

tolterodine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Tolterodine Tartrate results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of ACSL4 protein]

NCBI chr X:110,739,633...110,803,416
Ensembl chr X:110,739,648...110,803,261

G

aryl hydrocarbon receptor

decreases expression

ISO

Tolterodine Tartrate results in decreased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions

ISO

Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
affects metabolic processing
multiple interactions

ISO

CYP2D6 protein results in increased metabolism of Tolterodine Tartrate
CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate
Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]

PMID:10583026 PMID:28087463

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

ferritin heavy chain 1

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of FTH1 protein]

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

glutathione peroxidase 4

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX4 protein]

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

interleukin 1 beta

decreases expression
multiple interactions

ISO

Tolterodine Tartrate results in decreased expression of IL1B mRNA
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:32816093 PMID:37702107

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions
decreases expression

ISO

Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Tolterodine Tartrate results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 22 member 2

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Tolterodine Tartrate results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

transferrin receptor

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of TFRC protein]

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

tumor necrosis factor

multiple interactions

ISO

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

EXP

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

advanced glycosylation end product-specific receptor

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of AGER mRNA]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

EXP

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

activating transcription factor 4

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of ATF4 mRNA]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

EXP

Tramadol results in increased expression of BAX mRNA; Tramadol results in increased expression of BAX protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of BAX mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of BAX protein]

PMID:25550769 PMID:39848458

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

decreases activity

EXP

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of BCL2 mRNA; Tramadol results in decreased expression of BCL2 protein
Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2L1 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of BCL2L1 protein]
Tramadol results in decreased expression of BCL2L1 mRNA; Tramadol results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

affects activity
decreases activity
multiple interactions
increases expression

ISO
EXP

Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of CASP3 mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of CASP3 protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in increased expression of CASP3 mRNA; Tramadol results in increased expression of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080 PMID:39848458

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

creatine kinase B

decreases expression
multiple interactions

ISO
EXP

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

cAMP responsive element binding protein 1

increases phosphorylation

EXP

tramadol increases phosphorylation of Creb1 protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

ISO

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases response to substance
affects metabolic processing
decreases response to substance
affects response to substance
multiple interactions
decreases methylation
increases metabolic processing
affects methylation

ISO

CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

desmin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

dopamine receptor D2

increases expression

EXP

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

increases expression

EXP

Tramadol results in increased expression of DRD3 protein

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of EIF2AK3 mRNA]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of EIF2S1 mRNA]

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Tramadol increases expression of Fosb protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

gap junction protein, alpha 1

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutamic-oxaloacetic transaminase 1

increases expression
multiple interactions

EXP

Tramadol results in increased expression of GOT1 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases activity
increases expression
multiple interactions

EXP

Tramadol results in increased activity of GPT protein
Tramadol results in increased expression of GPT protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased activity of GPT protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080 PMID:39848458

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

hepatitis A virus cellular receptor 1

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

5-hydroxytryptamine receptor 2A

multiple interactions
increases expression
increases activity

EXP

Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

interferon gamma

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

increases expression
multiple interactions

EXP

Tramadol results in increased expression of IL1B mRNA; Tramadol results in increased expression of IL1B protein
Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

lactate dehydrogenase A

decreases expression

ISO

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

ISO

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of NFKB1 mRNA]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NLR family, pyrin domain containing 3

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of NLRP3 mRNA]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NPHS1 adhesion molecule, nephrin

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of NPHS1 protein
Rosmarinic Acid inhibits the reaction [Tramadol results in decreased expression of NPHS1 protein]

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521

G

opioid receptor, delta 1

affects binding
multiple interactions

EXP

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, kappa 1

multiple interactions
affects binding

EXP

[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671

G

opioid receptor, mu 1

multiple interactions
affects binding

EXP

[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases expression

EXP

Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of PARP1 mRNA]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate dehydrogenase kinase 3

increases expression

ISO

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:62,480,535...62,547,371
Ensembl chr X:62,480,535...62,547,371

G

prodynorphin

decreases expression

EXP

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

EXP

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

solute carrier family 2 member 4

multiple interactions

EXP

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 47 member 1

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

superoxide dismutase 1

decreases expression
multiple interactions

EXP

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

EXP

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

secreted phosphoprotein 1

multiple interactions
increases expression

EXP

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

tumor necrosis factor

multiple interactions
increases expression

EXP

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of TNF mRNA]; Rosmarinic Acid inhibits the reaction [Tramadol results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]
Tramadol results in increased expression of TNF mRNA; Tramadol results in increased expression of TNF protein

PMID:17377112 PMID:31618080 PMID:33645892 PMID:39848458

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin I3, cardiac type

increases expression
multiple interactions

EXP

Tramadol results in increased expression of TNNI3 protein
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

vimentin

multiple interactions

EXP

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

trospium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases transport

ISO

valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

solute carrier family 22 member 1

decreases activity
increases metabolic processing

ISO

trospium chloride results in decreased activity of SLC22A1 protein
SLC22A1 protein results in increased metabolism of trospium chloride

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

decreases activity

ISO

trospium chloride results in decreased activity of SLC22A2 protein

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier organic anion transporter family, member 1a4

increases metabolic processing
decreases activity

ISO

SLCO1A2 protein results in increased metabolism of trospium chloride
trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

solute carrier organic anion transporter family member 1B2

decreases activity

ISO

trospium chloride results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions
affects binding

EXP
ISO

ziprasidone results in decreased expression of and results in increased reduction of ALB protein
ziprasidone binds to ALB protein
[ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

catalase

increases expression

EXP

ziprasidone results in increased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

ISO

ziprasidone results in increased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

ziprasidone results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

heme oxygenase 1

increases expression

EXP

ziprasidone results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

5-hydroxytryptamine receptor 1A

multiple interactions

EXP

[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

5-hydroxytryptamine receptor 2A

multiple interactions

ISO

ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

ziprasidone results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP

ziprasidone results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

sterol-C5-desaturase

increases expression

ISO

ziprasidone results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

solute carrier family 22 member 5

multiple interactions

ISO

ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

SRY-box transcription factor 17

decreases localization

ISO

ziprasidone results in decreased localization of SOX17 protein

NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
pharmacological role	19772
neurotransmitter agent	16568
cholinergic drug	3726
cholinergic antagonist	2354
muscarinic antagonist	1592
(R,R)-tramadol +	50
(R,R)-tramadol hydrochloride +	0
(S)-carbinoxamine maleate	0
(S,S)-tramadol +	50
(S,S)-tramadol hydrochloride +	0
4-DAMP methiodide	1
4-DAMP(1+) +	12
4-diphenylacetoxy-N-methylpiperidine	0
AF-DX 384	0
Anoro Ellipta	0
NSC 23766 +	36
NSC 23766 trihydrochloride	0
aclidinium +	0
aclidinium bromide	0
anisotropine methylbromide	0
atropine	99
benzatropine +	329
benzquinamide +	0
biperiden +	10
biperiden hydrochloride	0
bromazine +	0
bromazine hydrochloride +	0
butropium +	0
butropium bromide	0
butylscopolamine +	1
butylscopolamine bromide	1
carbinoxamine +	2
carbinoxamine maleate +	0
cinnarizine	3
clemastine +	3
clemastine fumarate	0
clozapine	755
cyclopentolate +	0
cyclopentolate hydrochloride +	0
cycrimine +	0
cycrimine hydrochloride +	0
darifenacin +	3
darifenacin hydrobromide	0
deptropine +	1
deptropine citrate	0
dicyclomine +	1
dicyclomine hydrochloride	0
diphemanil methylsulfate	0
diphenhydramine +	21
diphenhydramine hydrochloride	0
diphenhydramine salicylate	0
esoxybutynin +	21
flavoxate	0
flavoxate hydrochloride	0
flutropium +	0
flutropium bromide	0
himbacine	0
homatropine methylbromide	0
ipratropium bromide +	0
ipratropium bromide hydrate	0
methoctramine	0
methoctramine tetrahydrochloride	13
metixene +	1
olanzapine	150
orphenadrine +	423
orphenadrine citrate	0
orphenadrine hydrochloride	0
oxybutynin +	21
pirenzepine +	8
piroheptine	0
piroheptine hydrochloride	0
pizotifen	1
pizotifen malate	0
pizotifen maleate	0
procyclidine +	13
profenamine +	2
profenamine hydrochloride	0
promazine +	4
propiomazine +	0
propyromazine +	0
propyromazine bromide	0
quinidine	59
ritropirronium bromide +	0
scopolamine	129
scopolamine hydrobromide (anhydrous) +	0
scopolamine hydrobromide trihydrate	0
scopolamine methobromide	0
thiethylperazine +	2
tiotropium	0
tiotropium bromide	8
tiotropium bromide hydrate +	0
tiquizium +	3
tiquizium bromide	3
tolterodine +	18
tramadol	50
tramadol hydrochloride	0
tridihexethyl +	0
trospium +	5
trospium chloride	5
umeclidinium +	0
umeclidinium bromide +	0
ziprasidone +	12
Path 2
Term	Annotations
CHEBI ontology	20874
role	20844
application	20572
pharmaceutical	20359
drug	20359
neurotransmitter agent	16568
cholinergic drug	3726
cholinergic antagonist	2354
muscarinic antagonist	1592
(R,R)-tramadol +	50
(R,R)-tramadol hydrochloride +	0
(S)-carbinoxamine maleate	0
(S,S)-tramadol +	50
(S,S)-tramadol hydrochloride +	0
4-DAMP methiodide	1
4-DAMP(1+) +	12
4-diphenylacetoxy-N-methylpiperidine	0
AF-DX 384	0
Anoro Ellipta	0
NSC 23766 +	36
NSC 23766 trihydrochloride	0
aclidinium +	0
aclidinium bromide	0
anisotropine methylbromide	0
atropine	99
benzatropine +	329
benzquinamide +	0
biperiden +	10
biperiden hydrochloride	0
bromazine +	0
bromazine hydrochloride +	0
butropium +	0
butropium bromide	0
butylscopolamine +	1
butylscopolamine bromide	1
carbinoxamine +	2
carbinoxamine maleate +	0
cinnarizine	3
clemastine +	3
clemastine fumarate	0
clozapine	755
cyclopentolate +	0
cyclopentolate hydrochloride +	0
cycrimine +	0
cycrimine hydrochloride +	0
darifenacin +	3
darifenacin hydrobromide	0
deptropine +	1
deptropine citrate	0
dicyclomine +	1
dicyclomine hydrochloride	0
diphemanil methylsulfate	0
diphenhydramine +	21
diphenhydramine hydrochloride	0
diphenhydramine salicylate	0
esoxybutynin +	21
flavoxate	0
flavoxate hydrochloride	0
flutropium +	0
flutropium bromide	0
himbacine	0
homatropine methylbromide	0
ipratropium bromide +	0
ipratropium bromide hydrate	0
methoctramine	0
methoctramine tetrahydrochloride	13
metixene +	1
olanzapine	150
orphenadrine +	423
orphenadrine citrate	0
orphenadrine hydrochloride	0
oxybutynin +	21
pirenzepine +	8
piroheptine	0
piroheptine hydrochloride	0
pizotifen	1
pizotifen malate	0
pizotifen maleate	0
procyclidine +	13
profenamine +	2
profenamine hydrochloride	0
promazine +	4
propiomazine +	0
propyromazine +	0
propyromazine bromide	0
quinidine	59
ritropirronium bromide +	0
scopolamine	129
scopolamine hydrobromide (anhydrous) +	0
scopolamine hydrobromide trihydrate	0
scopolamine methobromide	0
thiethylperazine +	2
tiotropium	0
tiotropium bromide	8
tiotropium bromide hydrate +	0
tiquizium +	3
tiquizium bromide	3
tolterodine +	18
tramadol	50
tramadol hydrochloride	0
tridihexethyl +	0
trospium +	5
trospium chloride	5
umeclidinium +	0
umeclidinium bromide +	0
ziprasidone +	12

paths to the root