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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzocycloheptapyridine
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Accession:CHEBI:48593 term browser browse the term
Synonyms:related_synonym: benzocycloheptapyridines


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azatadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO azatadine binds to and results in decreased activity of HRH1 protein CTD PMID:2864258 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248 		JBrowse link
desloratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of desloratadine CTD PMID:12584158 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril] CTD PMID:22095822 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Ace2 angiotensin converting enzyme 2 affects binding ISO desloratadine binds to ACE2 protein CTD PMID:33609497 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of ALPL protein] CTD PMID:39672344 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO desloratadine results in decreased expression of BCL2 mRNA; desloratadine results in decreased expression of BCL2 protein CTD PMID:36617552 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO desloratadine results in increased cleavage of CASP3 protein CTD PMID:36617552 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO desloratadine results in decreased expression of CCNB1 protein CTD PMID:36617552 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases phosphorylation ISO desloratadine results in increased phosphorylation of CDK1 protein CTD PMID:36617552 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis ISO CYP2D6 protein affects the chemical synthesis of desloratadine CTD PMID:15932952 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO desloratadine results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:39672344 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of GOT1 protein] CTD PMID:39672344 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of GPT protein] CTD PMID:39672344 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hpcal1 hippocalcin-like 1 affects response to substance
decreases expression
decreases myristoylation
multiple interactions 		ISO HPCAL1 protein affects the susceptibility to desloratadine
desloratadine results in decreased expression of HPCAL1 protein
desloratadine results in decreased myristoylation of HPCAL1 protein
Ammonium Chloride inhibits the reaction [desloratadine results in increased degradation of HPCAL1 protein]; desloratadine results in decreased expression of and results in increased degradation of HPCAL1 protein 		CTD PMID:36617552 NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO desloratadine binds to HRH1 protein CTD PMID:15482930 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] CTD PMID:39672344 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [montelukast co-treated with desloratadine] results in decreased expression of IL5 protein CTD PMID:15061398 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions 		ISO desloratadine results in decreased activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein 		CTD PMID:28551711 PMID:29143966 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of TAK1 protein] CTD PMID:39672344 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of MYD88 protein] CTD PMID:39672344 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nmt1 N-myristoyltransferase 1 affects response to substance
multiple interactions 		ISO NMT1 protein affects the susceptibility to desloratadine
desloratadine binds to and results in decreased activity of NMT1 protein 		CTD PMID:36617552 NCBI chr10:88,488,918...88,525,496
Ensembl chr10:88,488,990...88,522,729 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO [desloratadine results in increased susceptibility to Sorafenib] which results in increased cleavage of PARP1 protein; [Sorafenib results in increased susceptibility to desloratadine] which results in increased cleavage of PARP1 protein
desloratadine results in increased cleavage of PARP1 protein 		CTD PMID:36617552 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions 		ISO
EXP 		desloratadine results in decreased phosphorylation of RELA protein
desloratadine inhibits the reaction [Thioacetamide results in increased expression of RELA protein] 		CTD PMID:36617552 PMID:39672344 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO desloratadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:39672344 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of TLR4 protein] CTD PMID:39672344 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions EXP desloratadine inhibits the reaction [Thioacetamide results in increased expression of TRAF6 protein] CTD PMID:39672344 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
lonafarnib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of AKT1 protein; [Bortezomib co-treated with lonafarnib] results in decreased expression of AKT1 protein modified form CTD PMID:16118318 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; lonafarnib promotes the reaction [Bortezomib results in increased cleavage of BCL2 protein modified form] CTD PMID:15090542 PMID:16118318 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15090542 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO lonafarnib promotes the reaction [Bortezomib results in increased cleavage of BCL2L1 protein] CTD PMID:16118318 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15090542 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15090542 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:15090542 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP3 protein CTD PMID:16118318 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP8 protein CTD PMID:16118318 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage 		ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP9 protein
lonafarnib results in increased cleavage of CASP9 protein 		CTD PMID:16118318 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15090542 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15090542 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3A protein modified form CTD PMID:16118318 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3B protein modified form CTD PMID:16118318 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein] CTD PMID:15090542 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:21430599 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Lmna lamin A/C decreases farnesylation ISO lonafarnib results in decreased farnesylation of LMNA protein CTD PMID:16996129 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15090542 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO lonafarnib inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15090542 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:15090542 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15090542 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO lonafarnib results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:12673674 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lonafarnib inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; lonafarnib inhibits the reaction [TNF protein affects the localization of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15090542 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases activity
multiple interactions 		ISO lonafarnib results in decreased activity of RHEB protein
[lonafarnib results in decreased activity of RHEB protein] which results in increased susceptibility to Cisplatin 		CTD PMID:20554106 NCBI chr 4:11,012,173...11,053,860
Ensembl chr 4:11,012,643...11,053,931 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lonafarnib inhibits the reaction [TNF protein affects the localization of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein]; lonafarnib inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein] 		CTD PMID:15090542 PMID:21430599 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein] CTD PMID:15090542 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:15090542 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions 		ISO Loratadine results in decreased activity of ABCB11 protein
Loratadine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] 		CTD PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases export 		ISO ABCB1A protein affects the susceptibility to Loratadine
ABCB1 protein results in increased export of Loratadine 		CTD PMID:12584158 PMID:15502009 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loratadine CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Loratadine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Loratadine CTD PMID:22095822 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril] CTD PMID:22095822 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Ace2 angiotensin converting enzyme 2 affects binding ISO Loratadine binds to ACE2 protein CTD PMID:33609497 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Loratadine analog results in decreased activity of ALOX5 protein CTD PMID:15482930 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Loratadine results in decreased expression of AP1S1 mRNA CTD PMID:17567588 NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483 		JBrowse link
G Ar androgen receptor increases expression ISO Loratadine results in increased expression of AR mRNA CTD PMID:16407038 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Loratadine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity 		ISO Loratadine results in increased cleavage of CASP3 protein
Dasatinib promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP3 protein] 		CTD PMID:20570632 PMID:22700542 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions 		ISO Loratadine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP7 protein] 		CTD PMID:22700542 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Loratadine results in increased cleavage of CASP8 protein CTD PMID:20570632 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Loratadine results in increased cleavage of CASP9 protein CTD PMID:20570632 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Loratadine results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Loratadine; CYP2D6 protein affects the metabolism of Loratadine CTD PMID:15932952 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Loratadine analog results in decreased activity of CYP3A4 protein; Loratadine results in decreased activity of CYP3A4 protein CTD PMID:15482930 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Loratadine results in increased expression of ESR1 mRNA CTD PMID:16407038 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Loratadine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Loratadine results in increased expression of GDPD3 mRNA CTD PMID:15342952 NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606 		JBrowse link
G Hpn hepsin increases expression ISO Loratadine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Loratadine analog binds to HRH1 protein; Loratadine binds to HRH1 protein CTD PMID:15482930 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Loratadine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
affects activity
multiple interactions 		ISO Loratadine results in decreased activity of KCNH2 protein
Loratadine affects the activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Loratadine binds to and results in decreased activity of KCNH2 protein; Loratadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] 		CTD PMID:9658196 PMID:10604956 PMID:11705456 PMID:16278312 PMID:21158687 More... NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Lss lanosterol synthase increases expression ISO Loratadine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Loratadine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Loratadine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO Loratadine results in decreased expression of RPS6 protein modified form CTD PMID:20570632 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Loratadine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Loratadine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Loratadine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Tagln transgelin decreases expression ISO Loratadine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          nitrogen atom 19576
            nitrogen molecular entity 19576
              organonitrogen compound 19311
                organonitrogen heterocyclic compound 18491
                  benzocycloheptapyridine 75
                    (11S)-8-chloro-11-[1-(methylsulfonyl)piperidin-4-yl]-6-piperazin-1-yl-11H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                    2-Hydroxymethyl Loratadine 0
                    4-Hydroxymethyl Loratadine 0
                    4-\{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl\}piperidine-1-carboxamide + 28
                    8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                    MK-2461 0
                    azatadine + 1
                    desloratadine 27
                    loratadine 33
                    rupatadine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterotricyclic compound 16085
                                      benzocycloheptapyridine 75
                                        (11S)-8-chloro-11-[1-(methylsulfonyl)piperidin-4-yl]-6-piperazin-1-yl-11H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                                        2-Hydroxymethyl Loratadine 0
                                        4-Hydroxymethyl Loratadine 0
                                        4-\{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl\}piperidine-1-carboxamide + 28
                                        8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                                        MK-2461 0
                                        azatadine + 1
                                        desloratadine 27
                                        loratadine 33
                                        rupatadine 0
paths to the root