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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aminopiperidine
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Accession:CHEBI:48588 term browser browse the term
Synonyms:related_synonym: aminopiperidines


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4-amino-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase multiple interactions ISO 4-amino-TEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; 4-amino-TEMPO inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; 4-amino-TEMPO inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [4-amino-TEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
capivasertib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO capivasertib results in increased phosphorylation of AKT1 protein CTD PMID:26853465 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation ISO capivasertib results in decreased phosphorylation of AKT1S1 protein CTD PMID:26853465 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO capivasertib affects the reaction [bafilomycin A1 results in increased expression of BNIP3 protein] CTD PMID:26853465 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein] CTD PMID:26853465 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO bafilomycin A1 promotes the reaction [capivasertib results in increased expression of MAP1LC3B protein modified form] CTD PMID:26853465 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Rpl18 ribosomal protein L18 multiple interactions ISO capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPL18 mRNA]; capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPL18 protein] CTD PMID:37061066 NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452 		JBrowse link
G Rps21-ps1 ribosomal protein S21, pseudogene 1 multiple interactions ISO capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPS21 mRNA]; capivasertib inhibits the reaction [sodium arsenite results in increased expression of RPS21 protein] CTD PMID:37061066 NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO capivasertib results in decreased phosphorylation of RPS6 protein CTD PMID:26853465 PMID:32397857 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO capivasertib affects the expression of SQSTM1 protein CTD PMID:26853465 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO capivasertib results in decreased expression of SREBF1 protein CTD PMID:26853465 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 multiple interactions ISO capivasertib inhibits the reaction [sodium arsenite results in increased expression of UBA52 mRNA]; capivasertib inhibits the reaction [sodium arsenite results in increased expression of UBA52 protein] CTD PMID:37061066 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807 		JBrowse link
linagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:32567747 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] CTD PMID:32567747 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity EXP Linagliptin results in decreased activity of DPP4 protein CTD PMID:22125632 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of DUSP1 mRNA] CTD PMID:35122774 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]] CTD PMID:28619389 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA] CTD PMID:32567747 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]]; Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]] CTD PMID:28619389 PMID:35122774 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in increased expression of IL6 protein] CTD PMID:35122774 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]] CTD PMID:28619389 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO
EXP		 Linagliptin inhibits the reaction [Cuprizone results in increased expression of JAK2 protein modified form]
Linagliptin inhibits the reaction [Acetic Acid results in increased phosphorylation of JAK2 protein]		 CTD PMID:29864483 PMID:35122774 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of LHB protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of LHB protein]] CTD PMID:28619389 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of MBP mRNA] CTD PMID:29864483 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in increased expression of MTOR mRNA] CTD PMID:35122774 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]] CTD PMID:28619389 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of NR0B2 mRNA] CTD PMID:35122774 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of OLIG2 mRNA] CTD PMID:29864483 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152 		JBrowse link
G Plp1 proteolipid protein 1 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of PLP1 mRNA] CTD PMID:29864483 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP		 Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A protein]
Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of PPARGC1A mRNA]		 CTD PMID:32567747 PMID:35122774 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole affects the localization of RELA protein]]; Linagliptin inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Linagliptin inhibits the reaction [Letrozole affects the localization of RELA protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole affects the localization of RELA protein]]
Linagliptin inhibits the reaction [Cuprizone results in increased expression of RELA protein]		 CTD PMID:28619389 PMID:29864483 PMID:35122774 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO
EXP		 Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA]
Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA]		 CTD PMID:29864483 PMID:35122774 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in increased expression of SOCS3 mRNA] CTD PMID:35122774 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP		 Linagliptin inhibits the reaction [Cuprizone results in increased expression of STAT3 protein modified form]
Linagliptin inhibits the reaction [Acetic Acid results in increased phosphorylation of STAT3 protein]		 CTD PMID:29864483 PMID:35122774 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of TGFB1 protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of TGFB1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of TGFB1 protein]] CTD PMID:28619389 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Linagliptin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]]
Linagliptin inhibits the reaction [Cuprizone results in increased expression of TNF protein]		 CTD PMID:28619389 PMID:29864483 PMID:35122774 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          nitrogen atom 19003
            nitrogen molecular entity 19003
              organonitrogen compound 18855
                organonitrogen heterocyclic compound 18176
                  piperidines 7777
                    aminopiperidine 35
                      (2S,3R)-2-[(3S,6R)-3-amino-6-hydroxy-2-oxopiperidinyl]-3-hydroxybutanoic acid 0
                      (3R,4R)-1-\{6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl\}-4-(2,4,5-trifluorophenyl)piperidin-3-amine 0
                      (4-amino-2-\{[1-(methylsulfonyl)piperidin-4-yl]amino\}pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone 0
                      (4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one 0
                      1-(2,2,2-Trifluoroethyl)-4-piperidinylamine 0
                      1-(2-furoyl)-4-piperidinamine 0
                      2-(4-amino-1-piperidinyl)cyclopentanol 0
                      2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 0
                      2-[(3S)-3-aminopiperidin-1-yl]-1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-3,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-1-ium 0
                      2-[4-(\{2-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-oxoethyl\}amino)-4-methylpiperidin-1-yl]isonicotinic acid 0
                      3-amino-1-N-alloc-piperidine 0
                      4-(\{5-[(2-aminoethyl)amino]-2,4-dinitrophenyl\}amino)-TEMPO 0
                      4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidin-2-amine 0
                      4-\{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl\}-N-[(1S)-1-phenylethyl]pyrimidin-2-amine 0
                      4-\{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino\}-N-ethylpiperidine-1-carboxamide 0
                      4-amino-TEMPO + 1
                      4-aminopiperidine-1-carboxylic acid 0
                      6-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}-3-(carboxymethoxy)thieno[3,2-b][1]benzothiophene-2-carboxylic acid 0
                      AZD3463 0
                      N,N-Dimethyl-N-(4-piperidinyl)amine 0
                      N,n-diethyl-4-piperidinamine 0
                      N-Methyl-N-(tetrahydro-2-furanylmethyl)-4-piperidinamine 0
                      N1,n1,n2-trimethyl-n2-(4-piperidinyl)-1,2-ethanediamine 0
                      UNC0638 0
                      \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                      capivasertib 11
                      crenolanib 0
                      linagliptin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteromonocyclic compound 17817
                                    piperidines 7777
                                      aminopiperidine 35
                                        (2S,3R)-2-[(3S,6R)-3-amino-6-hydroxy-2-oxopiperidinyl]-3-hydroxybutanoic acid 0
                                        (3R,4R)-1-\{6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl\}-4-(2,4,5-trifluorophenyl)piperidin-3-amine 0
                                        (4-amino-2-\{[1-(methylsulfonyl)piperidin-4-yl]amino\}pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone 0
                                        (4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one 0
                                        1-(2,2,2-Trifluoroethyl)-4-piperidinylamine 0
                                        1-(2-furoyl)-4-piperidinamine 0
                                        2-(4-amino-1-piperidinyl)cyclopentanol 0
                                        2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 0
                                        2-[(3S)-3-aminopiperidin-1-yl]-1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-3,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-1-ium 0
                                        2-[4-(\{2-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-oxoethyl\}amino)-4-methylpiperidin-1-yl]isonicotinic acid 0
                                        3-amino-1-N-alloc-piperidine 0
                                        4-(\{5-[(2-aminoethyl)amino]-2,4-dinitrophenyl\}amino)-TEMPO 0
                                        4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidin-2-amine 0
                                        4-\{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl\}-N-[(1S)-1-phenylethyl]pyrimidin-2-amine 0
                                        4-\{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino\}-N-ethylpiperidine-1-carboxamide 0
                                        4-amino-TEMPO + 1
                                        4-aminopiperidine-1-carboxylic acid 0
                                        6-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}-3-(carboxymethoxy)thieno[3,2-b][1]benzothiophene-2-carboxylic acid 0
                                        AZD3463 0
                                        N,N-Dimethyl-N-(4-piperidinyl)amine 0
                                        N,n-diethyl-4-piperidinamine 0
                                        N-Methyl-N-(tetrahydro-2-furanylmethyl)-4-piperidinamine 0
                                        N1,n1,n2-trimethyl-n2-(4-piperidinyl)-1,2-ethanediamine 0
                                        UNC0638 0
                                        \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                                        capivasertib 11
                                        crenolanib 0
                                        linagliptin 24
paths to the root