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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-adrenergic drug
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Accession:CHEBI:48539 term browser browse the term
Definition:Any drug that acts on an alpha-adrenergic receptor.
Synonyms:related_synonym: alpha-adrenergic drugs


show annotations for term's descendants           Sort by:
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]		 CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 decreases expression
increases expression		 EXP Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein		 CTD PMID:16824628 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression		 EXP Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein		 CTD PMID:16824628 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions		 EXP Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]		 CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G JUP junction plakoglobin increases expression
decreases expression		 EXP Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA		 CTD PMID:16824628 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210 		JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1B adrenoceptor alpha 1B increases activity EXP Phenylephrine results in increased activity of ADRA1B protein CTD PMID:19376108 NCBI chr16:63,550,123...64,010,838
Ensembl chr16:63,550,130...63,603,034 		JBrowse link
G ADRA1D adrenoceptor alpha 1D increases activity EXP Phenylephrine results in increased activity of ADRA1D protein CTD PMID:19376108 NCBI chr17:31,517,021...31,537,361
Ensembl chr17:31,517,021...31,538,362 		JBrowse link
G C5 complement C5 affects response to substance EXP C5 protein affects the susceptibility to Phenylephrine CTD PMID:10750764 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5164
    role 5131
      biological role 5131
        pharmacological role 644
          neurotransmitter agent 207
            adrenergic agent 30
              alpha-adrenergic drug 8
                alpha-adrenergic agonist + 4
                alpha-adrenergic antagonist + 4
                apomorphine + 0
                zotepine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5164
    role 5131
      application 909
        pharmaceutical 744
          drug 744
            neurotransmitter agent 207
              adrenergic agent 30
                alpha-adrenergic drug 8
                  alpha-adrenergic agonist + 4
                  alpha-adrenergic antagonist + 4
                  apomorphine + 0
                  zotepine 0
paths to the root