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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-adrenergic drug
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Accession:CHEBI:48539 term browser browse the term
Definition:Any drug that acts on an alpha-adrenergic receptor.
Synonyms:related_synonym: alpha-adrenergic drugs


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP Carvedilol results in decreased activity of CASP3 protein CTD PMID:12875697 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Carvedilol results in decreased expression of FAS CTD PMID:12875697 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FASLG Fas ligand decreases expression EXP Carvedilol results in decreased expression of FASLG CTD PMID:12875697 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G NT5E 5'-nucleotidase ecto increases activity EXP Carvedilol results in increased activity of NT5E protein CTD PMID:15148268 NCBI chr12:45,491,028...45,520,019
Ensembl chr12:45,491,733...45,518,405 		JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions EXP Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein CTD PMID:17448375 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance		 EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine		 CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722 		JBrowse link
G GH1 growth hormone increases secretion EXP Clonidine results in increased secretion of GH1 protein CTD PMID:6248808 NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123 		JBrowse link
G NISCH nischarin multiple interactions
affects binding		 EXP Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein		 CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance		 EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine		 CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722 		JBrowse link
G GH1 growth hormone increases secretion EXP Clonidine results in increased secretion of GH1 protein CTD PMID:6248808 NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123 		JBrowse link
G NISCH nischarin affects binding
multiple interactions		 EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]		 CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases activity
multiple interactions		 EXP Clonidine results in increased activity of PIK3CG protein
[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]		 CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein		 CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance		 EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine		 CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722 		JBrowse link
G GH1 growth hormone increases secretion EXP Clonidine results in increased secretion of GH1 protein CTD PMID:6248808 NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123 		JBrowse link
G NISCH nischarin affects binding
multiple interactions		 EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]		 CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein		 CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Desipramine CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
dexmedetomidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin affects activity EXP Dexmedetomidine affects the activity of NISCH CTD PMID:7486159 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
idazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin multiple interactions EXP Idazoxan binds to and results in decreased activity of NISCH protein CTD PMID:8732285 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP Phenylephrine binds to and results in increased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486 		JBrowse link
G ADRA1D adrenoceptor alpha 1D multiple interactions EXP BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; Phenylephrine binds to and results in increased activity of ADRA1D protein CTD PMID:19371927 NCBI chr24:17,231,771...17,239,110
Ensembl chr24:17,213,643...17,214,761
Ensembl chr24:17,213,643...17,214,761 		JBrowse link
G REN renin increases secretion EXP Phenylephrine results in increased secretion of REN protein CTD PMID:6347479 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 multiple interactions EXP Risperidone binds to and results in decreased activity of DRD2 protein CTD PMID:16948927 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
yohimbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 497
    role 497
      biological role 497
        pharmacological role 164
          neurotransmitter agent 99
            adrenergic agent 27
              alpha-adrenergic drug 19
                alpha-adrenergic agonist + 12
                alpha-adrenergic antagonist + 10
                apomorphine + 0
                zotepine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 497
    role 497
      application 453
        pharmaceutical 448
          drug 448
            neurotransmitter agent 99
              adrenergic agent 27
                alpha-adrenergic drug 19
                  alpha-adrenergic agonist + 12
                  alpha-adrenergic antagonist + 10
                  apomorphine + 0
                  zotepine 0
paths to the root