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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apomorphine
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Accession:CHEBI:48538 term browser browse the term
Definition:An isoquinoline alkaloid that has formula C17H17NO2.
Synonyms:exact_synonym: 6abeta-aporphine-10,11-diol
 related_synonym: (-)-10,11-dihydroxyaporphine;   (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;   (R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol;   Apomorphin;   Formula=C17H17NO2;   InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1;   InChIKey=VMWNQDUVQKEIOC-CYBMUJFWSA-N;   R-(-)-apomorphine;   SMILES=[H][C@]12Cc3ccc(O)c(O)c3-c3cccc(CCN1C)c23
 alt_id: CHEBI:94845
 xref: Beilstein:29319;   Beilstein:3653944;   CAS:58-00-4;   DrugBank:DB00714;   Drug_Central:228;   LINCS:LSM-25611
 xref_mesh: MESH:D001058
 xref: VSDB:2964;   Wikipedia:Apomorphine


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apomorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy1 amylase alpha 1 multiple interactions EXP Apomorphine results in increased secretion of and results in increased activity of AMY1A protein; Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:204,071,098...204,086,239 		JBrowse link
G Avp arginine vasopressin increases expression
multiple interactions 		ISO Apomorphine results in increased expression of AVP protein
Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein] 		CTD PMID:16575035 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form] CTD PMID:25633564 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO Apomorphine results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,742,875...9,786,861 		JBrowse link
G Cck cholecystokinin multiple interactions
decreases activity 		EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686 		JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Apomorphine CTD PMID:11702094 NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Apomorphine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Apomorphine binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]
[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] 		CTD PMID:8103921 PMID:15985612 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases response to substance
affects response to substance 		ISO
EXP 		[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]
DRD2 protein results in increased susceptibility to Apomorphine
DRD2 protein affects the susceptibility to Apomorphine
Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein] 		CTD PMID:2571179 PMID:7520908 PMID:8103596 PMID:8103921 PMID:14639100 More... NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Drd3 dopamine receptor D3 increases response to substance ISO DRD3 protein results in increased susceptibility to Apomorphine CTD PMID:19497322 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Apomorphine results in increased expression of FOS protein CTD PMID:10904129 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO Apomorphine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:143,757,389...143,770,430
Ensembl chr 1:143,757,391...143,773,497 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP GDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240 		JBrowse link
G Gh1 growth hormone 1 increases secretion
increases expression 		ISO Apomorphine results in increased secretion of GH1 protein
Apomorphine results in increased expression of GH1 protein 		CTD PMID:993808 PMID:8889285 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression
decreases secretion 		ISO Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Apomorphine results in decreased expression of HAMP mRNA
Apomorphine results in decreased secretion of HAMP protein modified form 		CTD PMID:25633564 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine] CTD PMID:8539317 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 increases response to substance
multiple interactions 		EXP HTR6 protein results in increased susceptibility to Apomorphine
Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine] 		CTD PMID:17920665 NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:156,579,901...156,595,147 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Apomorphine inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein] CTD PMID:14599342 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO Apomorphine results in increased activity of ODC1 protein CTD PMID:10354516 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Penk proenkephalin multiple interactions EXP Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA] CTD PMID:17719177 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705 		JBrowse link
G Prl prolactin decreases expression ISO Apomorphine results in decreased expression of PRL protein CTD PMID:8889285 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Pvalb parvalbumin affects expression EXP Apomorphine affects the expression of PVALB protein CTD PMID:15238432 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance ISO RGS9 affects the susceptibility to Apomorphine CTD PMID:15728856 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,696,556...94,770,387 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions EXP SHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Apomorphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Sst somatostatin affects secretion EXP Apomorphine affects the secretion of SST protein CTD PMID:17961553 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823 		JBrowse link
G Syt7 synaptotagmin 7 multiple interactions EXP [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:216,456,259...216,518,718 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:17719177 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
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  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            emetic 7903
              apomorphine 29
                apomorphine hydrochloride 0
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  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
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            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        tertiary amino compound 11023
                                          aporphine 29
                                            apomorphine 29
                                              apomorphine hydrochloride 0
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