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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of hydratropic acid |
CTD |
PMID:15117964 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases glucuronidation |
EXP |
UGT2B1 protein results in increased glucuronidation of hydratropic acid |
CTD |
PMID:8302279 |
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NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Hyoscyamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Atropine results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO EXP |
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein] [Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]] [1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] |
CTD |
PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 More...
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adcy5 |
adenylate cyclase 5 |
increases response to substance |
ISO |
ADCY5 protein results in increased susceptibility to Atropine |
CTD |
PMID:12869393 |
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NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Aqp5 |
aquaporin 5 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] |
CTD |
PMID:26208470 |
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NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] |
CTD |
PMID:21971501 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcar1 |
BCAR1 scaffold protein, Cas family member |
multiple interactions |
ISO |
Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] |
CTD |
PMID:10537051 |
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NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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G |
Bche |
butyrylcholinesterase |
multiple interactions |
EXP ISO |
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein [BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX |
CTD |
PMID:17963125 PMID:22981459 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bdkrb2 |
bradykinin receptor B2 |
multiple interactions |
ISO |
BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] |
CTD |
PMID:10614985 |
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NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] |
CTD |
PMID:18472332 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Cacna1e |
calcium voltage-gated channel subunit alpha1 E |
multiple interactions |
EXP |
Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] |
CTD |
PMID:12663092 |
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NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
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G |
Calca |
calcitonin-related polypeptide alpha |
affects activity |
EXP |
Atropine affects the activity of CALCA protein |
CTD |
PMID:7906887 PMID:10075105 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Casp3 |
caspase 3 |
increases expression |
EXP |
Atropine results in increased expression of CASP3 mRNA |
CTD |
PMID:19815060 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] |
CTD |
PMID:22245128 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccna1 |
cyclin A1 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CCNA1 mRNA [Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccnd3 |
cyclin D3 |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CCNE1 mRNA [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccne2 |
cyclin E2 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA Atropine results in increased expression of CCNE2 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] |
CTD |
PMID:16879495 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cdc20 |
cell division cycle 20 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA Atropine results in increased expression of CDC20 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc6 |
cell division cycle 6 |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA |
CTD |
PMID:17390078 |
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NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA Atropine results in increased expression of CDK1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] |
CTD |
PMID:9311626 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions decreases activity |
ISO |
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] Atropine results in decreased activity of CHRM1 protein Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein] |
CTD |
PMID:16439611 PMID:18316702 PMID:31830555 |
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NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
ISO |
Atropine binds to and results in decreased activity of CHRM2 protein |
CTD |
PMID:15140916 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions decreases activity |
ISO |
Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein] Atropine results in decreased activity of CHRM3 protein |
CTD |
PMID:15140916 PMID:20708676 PMID:31830555 |
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NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
multiple interactions affects binding |
ISO |
[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] |
CTD |
PMID:16709648 |
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NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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G |
Chrm5 |
cholinergic receptor, muscarinic 5 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] |
CTD |
PMID:31323226 |
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NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions affects binding |
ISO EXP |
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]] Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:15733544 PMID:21791372 |
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NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
affects binding multiple interactions |
ISO EXP |
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]] Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] |
CTD |
PMID:15733544 PMID:21791372 |
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NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] |
CTD |
PMID:21971501 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
multiple interactions |
EXP ISO |
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein] [Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein |
CTD |
PMID:12039681 PMID:12906840 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] |
CTD |
PMID:17390078 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] |
CTD |
PMID:22245128 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Dvl2 |
dishevelled segment polarity protein 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] |
CTD |
PMID:17390078 |
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NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] |
CTD |
PMID:12906840 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
multiple interactions |
ISO |
atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells] |
RGD |
PMID:31227218 |
RGD:153298919 |
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] |
CTD |
PMID:17390078 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] |
CTD |
PMID:7968354 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] |
CTD |
PMID:7968354 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Ezr |
ezrin |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] |
CTD |
PMID:17390078 |
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NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein |
CTD |
PMID:30515700 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein |
CTD |
PMID:30515700 |
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NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Atropine results in increased expression of FOS protein Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA] [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] |
CTD |
PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
EXP |
Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] |
CTD |
PMID:16959836 |
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NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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G |
Glra1 |
glycine receptor, alpha 1 |
multiple interactions |
ISO |
Atropine binds to and results in decreased activity of GLRA1 protein |
CTD |
PMID:15081878 |
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NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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G |
Grm4 |
glutamate metabotropic receptor 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
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NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] |
CTD |
PMID:22245128 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] |
CTD |
PMID:22245128 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] |
CTD |
PMID:22245128 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] |
CTD |
PMID:21971501 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] |
CTD |
PMID:7968354 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
multiple interactions |
ISO |
Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
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NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] |
CTD |
PMID:17390078 |
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NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Ltf |
lactotransferrin |
multiple interactions |
ISO |
Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] |
CTD |
PMID:11112886 |
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NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21971501 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:21971501 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21971501 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:21971501 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mcm4 |
minichromosome maintenance complex component 4 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA Atropine results in increased expression of MCM4 mRNA |
CTD |
PMID:17390078 |
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NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
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G |
Mcm6 |
minichromosome maintenance complex component 6 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of MCM6 mRNA [Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA |
CTD |
PMID:17390078 |
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NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
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G |
Nefh |
neurofilament heavy chain |
affects expression |
EXP |
Atropine affects the expression of NEFH mRNA |
CTD |
PMID:22954530 |
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NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Atropine results in increased expression of NLRP3 mRNA |
CTD |
PMID:28138970 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] |
CTD |
PMID:15610444 PMID:16944022 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Notch4 |
notch receptor 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] |
CTD |
PMID:17390078 |
|
NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
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G |
Nppa |
natriuretic peptide A |
affects activity |
EXP |
Atropine affects the activity of NPPA protein modified form |
CTD |
PMID:1363893 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Oprl1 |
opioid related nociceptin receptor 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] |
CTD |
PMID:12007927 |
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NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] |
CTD |
PMID:12762645 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pnoc |
prepronociceptin |
multiple interactions |
EXP |
Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] |
CTD |
PMID:12007927 |
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NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] |
CTD |
PMID:7588217 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] |
CTD |
PMID:18812576 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] |
CTD |
PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] |
CTD |
PMID:10537051 |
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NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G |
Pxn |
paxillin |
multiple interactions |
ISO |
Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] |
CTD |
PMID:10537051 |
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NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
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G |
Rac3 |
Rac family small GTPase 3 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] |
CTD |
PMID:17390078 |
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NCBI chr10:106,002,808...106,005,243
Ensembl chr10:105,993,087...106,005,260
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] |
CTD |
PMID:21971501 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] |
CTD |
PMID:17390078 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:16263091 PMID:21641380 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:16263091 PMID:21599003 PMID:23770354 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
increases uptake multiple interactions |
ISO |
SLC22A3 protein results in increased uptake of Atropine Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:16263091 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Atropine results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] |
CTD |
PMID:22245128 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Spn |
sialophorin |
increases response to substance |
ISO |
SPN protein results in increased susceptibility to Atropine |
CTD |
PMID:18711009 |
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NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] |
CTD |
PMID:7761789 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] |
CTD |
PMID:18472332 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] |
CTD |
PMID:22245128 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] |
CTD |
PMID:12762645 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trio |
trio Rho guanine nucleotide exchange factor |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] |
CTD |
PMID:17390078 |
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NCBI chr 2:78,505,069...78,801,384
Ensembl chr 2:78,505,070...78,803,135
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
decreases response to substance |
ISO |
TRPA1 gene mutant form results in decreased susceptibility to Atropine |
CTD |
PMID:29627347 |
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NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
EXP |
[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] |
CTD |
PMID:15891268 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Tspo |
translocator protein |
multiple interactions |
EXP |
[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein |
CTD |
PMID:33823148 |
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NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] |
CTD |
PMID:22245128 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression |
EXP |
Scopolamine results in decreased expression of ABCB1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
EXP |
Scopolamine results in increased expression of ABCG1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Ache |
acetylcholinesterase |
multiple interactions increases expression affects activity increases activity decreases activity decreases expression affects response to substance increases response to substance |
ISO EXP |
kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein] Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein Scopolamine affects the activity of ACHE protein Scopolamine results in decreased activity of ACHE protein Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein] Scopolamine results in decreased expression of ACHE protein 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; polygalacic acid inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein] ACHE affects the susceptibility to Scopolamine ACHE protein results in increased susceptibility to Scopolamine |
CTD |
PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 PMID:20694781 PMID:20871768 PMID:22426032 PMID:26408985 PMID:26434561 PMID:26926176 PMID:27717698 PMID:28837785 PMID:29133030 PMID:31077737 PMID:32001261 PMID:34371027 More...
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adora3 |
adenosine A3 receptor |
multiple interactions |
ISO |
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:12672554 |
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NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:11707427 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
EXP |
Scopolamine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:27346436 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apba1 |
amyloid beta precursor protein binding family A member 1 |
increases expression |
EXP |
Scopolamine results in increased expression of APBA1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 1:221,363,769...221,569,496
Ensembl chr 1:221,363,778...221,566,553
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G |
Aplp2 |
amyloid beta precursor like protein 2 |
increases expression |
EXP |
Scopolamine results in increased expression of APLP2 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
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G |
App |
amyloid beta precursor protein |
decreases cleavage |
ISO |
Scopolamine results in decreased cleavage of APP protein |
CTD |
PMID:16423497 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
decreases expression decreases expression |
EXP ISO |
Scopolamine results in decreased expression of ARC mRNA scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus |
CTD RGD |
PMID:17540011 PMID:24012642 |
RGD:401938610 |
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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G |
Arg2 |
arginase 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of ARG2 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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G |
Arl4d |
ARF like GTPase 4D |
decreases expression |
EXP |
Scopolamine results in decreased expression of ARL4D mRNA |
CTD |
PMID:17540011 |
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NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
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G |
Avp |
arginine vasopressin |
multiple interactions |
EXP |
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:11553362 |
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NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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G |
Avpr1a |
arginine vasopressin receptor 1A |
multiple interactions |
EXP |
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:11553362 |
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NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein Galantamine inhibits the reaction [Scopolamine results in increased expression of BAX protein]; intybin inhibits the reaction [Scopolamine results in increased expression of BAX protein] dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA] |
CTD |
PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
increases expression |
EXP |
Scopolamine results in increased expression of BCAT1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein Galantamine inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein] dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein] |
CTD |
PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions decreases expression |
EXP ISO |
Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA] Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein [acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein] |
CTD |
PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 PMID:29476728 PMID:31077737 PMID:34371027 More...
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Cacna1d |
calcium voltage-gated channel subunit alpha1 D |
increases expression |
EXP |
Scopolamine results in increased expression of CACNA1D mRNA |
CTD |
PMID:12818353 |
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NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of CAMKK2 mRNA |
CTD |
PMID:17540011 |
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NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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G |
Cartpt |
CART prepropeptide |
decreases expression |
EXP |
Scopolamine results in decreased expression of CARTPT mRNA |
CTD |
PMID:17540011 |
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NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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G |
Casp3 |
caspase 3 |
increases expression increases cleavage multiple interactions increases activity |
ISO EXP |
Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein Scopolamine results in increased cleavage of CASP3 protein Galantamine inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]; intybin inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein] Scopolamine results in increased activity of CASP3 protein dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA] |
CTD |
PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions decreases activity increases activity |
ISO EXP |
acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein] Galantamine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; intybin inhibits the reaction [Scopolamine results in decreased activity of CAT protein] |
CTD |
PMID:20673844 PMID:27346436 PMID:27717698 PMID:31077737 PMID:34371027 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cd3e |
CD3 epsilon subunit of T-cell receptor complex |
decreases expression |
EXP |
Scopolamine results in decreased expression of CD3E mRNA |
CTD |
PMID:17540011 |
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NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022
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G |
Cdkl4 |
cyclin-dependent kinase-like 4 |
increases expression |
EXP |
Scopolamine results in increased expression of CDKL4 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 6:14,449,822...14,492,568
Ensembl chr 6:14,450,681...14,492,046
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G |
Chat |
choline O-acetyltransferase |
decreases activity multiple interactions |
ISO |
Scopolamine results in decreased activity of CHAT protein protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] |
CTD |
PMID:20694781 PMID:26408985 PMID:29133030 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein] Scopolamine results in increased expression of CHRM1 mRNA 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA] |
CTD |
PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261 |
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NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
increases response to substance |
ISO |
CHRM4 protein results in increased susceptibility to Scopolamine |
CTD |
PMID:12729838 |
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NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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G |
Chrm5 |
cholinergic receptor, muscarinic 5 |
decreases response to substance |
ISO |
CHRM5 protein results in decreased susceptibility to Scopolamine |
CTD |
PMID:13679217 |
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NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
affects binding multiple interactions |
ISO |
Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein] Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] |
CTD |
PMID:15733544 |
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NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
affects binding multiple interactions |
ISO |
Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein] Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] |
CTD |
PMID:15733544 |
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NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Coch |
cochlin |
decreases expression |
EXP |
Scopolamine results in decreased expression of COCH mRNA |
CTD |
PMID:12818353 |
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NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
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G |
Coro1b |
coronin 1B |
increases expression |
EXP |
Scopolamine results in increased expression of CORO1B mRNA |
CTD |
PMID:12818353 |
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NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
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G |
Cox5b |
cytochrome c oxidase subunit 5B |
increases expression |
EXP |
Scopolamine results in increased expression of COX5B mRNA |
CTD |
PMID:12818353 |
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NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases phosphorylation multiple interactions |
ISO |
Scopolamine results in decreased phosphorylation of CREB1 protein acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:26408985 PMID:31077737 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cryab |
crystallin, alpha B |
increases expression |
EXP |
Scopolamine results in increased expression of CRYAB mRNA |
CTD |
PMID:17540011 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions decreases response to substance |
ISO |
IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] |
CTD |
PMID:8877002 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cxcr5 |
C-X-C motif chemokine receptor 5 |
decreases expression |
EXP |
Scopolamine results in decreased expression of CXCR5 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
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G |
Ddc |
dopa decarboxylase |
decreases expression |
EXP |
Scopolamine results in decreased expression of DDC mRNA |
CTD |
PMID:17540011 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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G |
Dguok |
deoxyguanosine kinase |
increases expression |
EXP |
Scopolamine results in increased expression of DGUOK mRNA |
CTD |
PMID:17540011 |
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NCBI chr 4:115,987,101...116,014,733
Ensembl chr 4:115,979,094...116,014,733
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G |
Dio2 |
iodothyronine deiodinase 2 |
increases expression |
EXP |
Scopolamine results in increased expression of DIO2 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dusp5 |
dual specificity phosphatase 5 |
decreases expression |
EXP |
Scopolamine results in decreased expression of DUSP5 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dusp6 |
dual specificity phosphatase 6 |
decreases expression |
EXP |
Scopolamine results in decreased expression of DUSP6 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Egfr |
epidermal growth factor receptor |
decreases expression |
EXP |
Scopolamine results in decreased expression of EGFR mRNA |
CTD |
PMID:12818353 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions decreases expression |
EXP ISO |
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA] Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] Scopolamine results in decreased expression of EGR1 mRNA |
CTD |
PMID:8861055 PMID:17540011 PMID:29133030 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of EGR2 mRNA |
CTD |
PMID:17540011 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases expression |
EXP |
Scopolamine results in increased expression of EIF2S1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eml1 |
EMAP like 1 |
decreases expression |
EXP |
Scopolamine results in decreased expression of EML1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression increases expression |
EXP ISO |
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA] Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein] Scopolamine results in decreased expression of FOS mRNA |
CTD |
PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 PMID:17920665 PMID:29133030 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
increases expression |
EXP |
Scopolamine results in increased expression of GABBR1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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G |
Gap43 |
growth associated protein 43 |
decreases expression multiple interactions |
ISO |
Scopolamine results in decreased expression of GAP43 protein Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein] |
CTD |
PMID:22096544 |
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NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions decreases expression |
ISO |
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein] Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein |
CTD |
PMID:22096544 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gjb2 |
gap junction protein, beta 2 |
increases expression |
EXP |
Scopolamine results in increased expression of GJB2 mRNA |
CTD |
PMID:17540011 |
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NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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G |
Gpc3 |
glypican 3 |
decreases expression |
EXP |
Scopolamine results in decreased expression of GPC3 mRNA |
CTD |
PMID:12818353 |
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NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
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G |
Grm4 |
glutamate metabotropic receptor 4 |
multiple interactions |
ISO |
Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
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NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity multiple interactions |
ISO |
Scopolamine results in decreased activity of GSR protein Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein] |
CTD |
PMID:26408985 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gypc |
glycophorin C |
decreases expression |
EXP |
Scopolamine results in decreased expression of GYPC mRNA |
CTD |
PMID:17540011 |
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NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein] |
CTD |
PMID:32001261 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Homer1 |
homer scaffold protein 1 |
decreases expression |
EXP |
Scopolamine results in decreased expression of HOMER1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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G |
Hrh1 |
histamine receptor H 1 |
multiple interactions |
EXP |
[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine] |
CTD |
PMID:19215234 |
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NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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G |
Hrh2 |
histamine receptor H 2 |
multiple interactions |
EXP |
[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine] |
CTD |
PMID:11640976 PMID:19215234 |
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NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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G |
Hrh3 |
histamine receptor H3 |
multiple interactions |
EXP |
[clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:16488453 |
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NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
increases expression |
EXP |
Scopolamine results in increased expression of HSPA2 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions increases expression |
EXP |
[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine] Scopolamine increases expression of Htr1a mRNA in amygdala, hippocampal formation; Scopolamine increases expression of Htr1a protein in amygdala, hippocampal formation |
CTD RGD |
PMID:10578133 PMID:27760517 |
RGD:405850209 |
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr2c |
5-hydroxytryptamine receptor 2C |
increases expression |
EXP |
Scopolamine results in increased expression of HTR2C mRNA |
CTD |
PMID:17540011 |
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NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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G |
Htr6 |
5-hydroxytryptamine receptor 6 |
decreases expression |
EXP |
Scopolamine results in decreased expression of HTR6 mRNA |
CTD |
PMID:19733250 |
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NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
EXP |
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA] |
CTD |
PMID:21161262 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
decreases expression multiple interactions |
ISO |
Scopolamine results in decreased expression of IL10 protein acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; polygalacic acid inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] |
CTD |
PMID:26926176 PMID:31077737 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1a |
interleukin 1 alpha |
decreases response to substance |
ISO |
IL1A protein results in decreased susceptibility to Scopolamine |
CTD |
PMID:8003924 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
ISO EXP |
Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA] acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; polygalacic acid inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein] |
CTD |
PMID:18357464 PMID:19426756 PMID:21161262 PMID:26926176 PMID:31077737 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
ISO |
IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine] |
CTD |
PMID:8877002 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP ISO |
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA] acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein] Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein |
CTD |
PMID:18357464 PMID:21161262 PMID:31077737 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
increases expression |
EXP |
Scopolamine results in increased expression of ITPR1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression |
EXP ISO |
Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA] Scopolamine results in decreased expression of JUN protein Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein] |
CTD |
PMID:11337201 PMID:29133030 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Scopolamine results in decreased expression of JUNB mRNA |
CTD |
PMID:17540011 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Kcna4 |
potassium voltage-gated channel subfamily A member 4 |
increases expression |
EXP |
Scopolamine results in increased expression of KCNA4 mRNA |
CTD |
PMID:12579815 |
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NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
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G |
Kcnb1 |
potassium voltage-gated channel subfamily B member 1 |
increases expression |
EXP |
Scopolamine results in increased expression of KCNB1 mRNA |
CTD |
PMID:12579815 PMID:15567561 |
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NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
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G |
Kcnd2 |
potassium voltage-gated channel subfamily D member 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of KCND2 mRNA |
CTD |
PMID:12579815 |
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NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
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G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
multiple interactions |
ISO |
Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
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NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
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G |
Klf2 |
KLF transcription factor 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of KLF2 mRNA |
CTD |
PMID:17540011 |
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NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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G |
Klf4 |
KLF transcription factor 4 |
decreases expression |
EXP |
Scopolamine results in decreased expression of KLF4 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Lnpep |
leucyl and cystinyl aminopeptidase |
multiple interactions |
ISO |
[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:11707427 |
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NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
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G |
Madd |
MAP-kinase activating death domain |
increases expression |
EXP |
Scopolamine results in increased expression of MADD mRNA |
CTD |
PMID:12818353 |
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NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression multiple interactions |
ISO |
Scopolamine results in decreased expression of MAP2 protein Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein] |
CTD |
PMID:22096544 |
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NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Mapt |
microtubule-associated protein tau |
decreases expression |
EXP |
Scopolamine results in decreased expression of MAPT mRNA |
CTD |
PMID:12818353 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mbp |
myelin basic protein |
decreases expression multiple interactions |
ISO |
Scopolamine results in decreased expression of MBP protein Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] |
CTD |
PMID:29476728 |
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NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
decreases expression |
ISO EXP |
Scopolamine results in decreased expression of MUC5AC protein |
CTD |
PMID:18357464 PMID:21161262 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Nefh |
neurofilament heavy chain |
multiple interactions decreases expression |
ISO |
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein] |
CTD |
PMID:22096544 |
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NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases expression |
ISO EXP |
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein] Galantamine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein] |
CTD |
PMID:27346436 PMID:32001261 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Ngf |
nerve growth factor |
decreases response to substance decreases secretion multiple interactions increases response to substance |
EXP ISO |
NGF protein results in decreased susceptibility to Scopolamine Scopolamine results in decreased secretion of NGF protein Galantamine promotes the reaction [Scopolamine results in decreased secretion of NGF protein]; intybin inhibits the reaction [Scopolamine results in decreased secretion of NGF protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA] NGF protein results in increased susceptibility to Scopolamine |
CTD |
PMID:1661212 PMID:8635431 PMID:16405025 PMID:27346436 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
ISO |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] |
CTD |
PMID:26408985 PMID:31077737 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nova1 |
NOVA alternative splicing regulator 1 |
multiple interactions |
EXP |
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA] |
CTD |
PMID:20470870 |
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NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289
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G |
Nova2 |
NOVA alternative splicing regulator 2 |
multiple interactions |
EXP |
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA] |
CTD |
PMID:20470870 |
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NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions decreases expression |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] |
CTD |
PMID:26408985 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
increases expression |
EXP |
Scopolamine results in increased expression of NQO2 mRNA |
CTD |
PMID:20861374 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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G |
Nr1d1 |
nuclear receptor subfamily 1, group D, member 1 |
decreases expression |
EXP |
Scopolamine results in decreased expression of NR1D1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
decreases expression |
EXP |
Scopolamine results in decreased expression of NR4A1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Ntf3 |
neurotrophin 3 |
multiple interactions |
EXP |
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA] |
CTD |
PMID:8635431 |
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NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
multiple interactions decreases expression |
EXP ISO |
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] Scopolamine results in decreased expression of NTRK2 protein [acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein] |
CTD |
PMID:8635431 PMID:29476728 PMID:31077737 |
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NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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G |
Ntrk3 |
neurotrophic receptor tyrosine kinase 3 |
multiple interactions |
EXP |
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA] |
CTD |
PMID:8635431 |
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NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
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G |
Pdcd4 |
programmed cell death 4 |
increases expression |
EXP |
Scopolamine results in increased expression of PDCD4 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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G |
Pdyn |
prodynorphin |
decreases response to substance multiple interactions increases expression |
ISO EXP |
PDYN protein modified form results in decreased susceptibility to Scopolamine MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine] Scopolamine results in increased expression of PDYN mRNA |
CTD |
PMID:7768285 PMID:17540011 |
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NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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G |
Penk |
proenkephalin |
multiple interactions |
EXP |
Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] |
CTD |
PMID:7637876 |
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NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Pgam1 |
phosphoglycerate mutase 1 |
decreases expression |
EXP |
Scopolamine results in decreased expression of PGAM1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
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G |
Prep |
prolyl endopeptidase |
increases response to substance increases expression multiple interactions |
EXP |
PREP protein results in increased susceptibility to Scopolamine Scopolamine results in increased expression of PREP protein Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein] |
CTD |
PMID:17244263 PMID:18318186 |
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NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
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G |
Prkra |
protein activator of interferon induced protein kinase EIF2AK2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of PRKRA mRNA |
CTD |
PMID:12818353 |
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NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347
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G |
Psen2 |
presenilin 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of PSEN2 mRNA |
CTD |
PMID:12818353 |
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NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
Scopolamine results in increased expression of PTGS2 protein acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein] |
CTD |
PMID:26408985 PMID:31077737 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rab14 |
RAB14, member RAS oncogene family |
increases expression |
EXP |
Scopolamine results in increased expression of RAB14 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172
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G |
Rapgef3 |
Rap guanine nucleotide exchange factor 3 |
decreases expression |
EXP |
Scopolamine results in decreased expression of RAPGEF3 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein] |
CTD |
PMID:19182383 PMID:19426756 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rem2 |
RRAD and GEM like GTPase 2 |
decreases expression |
EXP |
Scopolamine results in decreased expression of REM2 mRNA |
CTD |
PMID:17540011 |
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NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429
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G |
Rgs7bp |
regulator of G-protein signaling 7 binding protein |
decreases expression |
EXP |
Scopolamine results in decreased expression of RGS7BP mRNA |
CTD |
PMID:17540011 |
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NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505
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G |
Robo3 |
roundabout guidance receptor 3 |
decreases expression |
EXP |
Scopolamine results in decreased expression of ROBO3 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 8:37,133,542...37,151,674
Ensembl chr 8:37,133,916...37,151,315
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G |
Rraga |
Ras-related GTP binding A |
increases expression |
EXP |
Scopolamine results in increased expression of RRAGA mRNA |
CTD |
PMID:12818353 |
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NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
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G |
S100a4 |
S100 calcium-binding protein A4 |
decreases expression |
EXP |
Scopolamine results in decreased expression of S100A4 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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G |
S1pr1 |
sphingosine-1-phosphate receptor 1 |
increases expression |
EXP |
Scopolamine results in increased expression of S1PR1 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
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G |
Scamp2 |
secretory carrier membrane protein 2 |
increases expression |
EXP |
Scopolamine results in increased expression of SCAMP2 mRNA |
CTD |
PMID:12818353 |
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NCBI chr 8:57,965,612...57,992,248
Ensembl chr 8:57,965,631...57,992,646
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G |
Sigmar1 |
sigma non-opioid intracellular receptor 1 |
multiple interactions |
ISO |
[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine |
CTD |
PMID:12028363 |
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NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases expression |
EXP |
Scopolamine results in increased expression of SULT1A1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Syp |
synaptophysin |
multiple interactions decreases expression increases expression |
EXP ISO |
cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein] dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA] |
CTD |
PMID:20188767 PMID:34371027 |
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NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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G |
Tac1 |
tachykinin, precursor 1 |
decreases response to substance |
EXP |
TAC1 protein modified form results in decreased susceptibility to Scopolamine |
CTD |
PMID:20600432 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO EXP |
acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein] Scopolamine results in increased expression of TNF mRNA Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein |
CTD |
PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnrc6a |
trinucleotide repeat containing adaptor 6A |
decreases expression |
EXP |
Scopolamine results in decreased expression of TNRC6A mRNA |
CTD |
PMID:17540011 |
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NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660
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G |
Tpd52l1 |
TPD52 like 1 |
increases expression |
EXP |
Scopolamine results in increased expression of TPD52L1 mRNA |
CTD |
PMID:17540011 |
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NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
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G |
Vgf |
VGF nerve growth factor inducible |
decreases expression |
EXP |
Scopolamine results in decreased expression of VGF mRNA |
CTD |
PMID:17540011 |
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NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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G |
Vip |
vasoactive intestinal peptide |
decreases response to substance |
EXP |
VIP protein results in decreased susceptibility to Scopolamine |
CTD |
PMID:8208360 |
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NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Atropine results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA |
CTD |
PMID:17390078 |
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NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO EXP |
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein] [1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] [Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]] |
CTD |
PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 PMID:21787676 PMID:22783142 PMID:23047022 PMID:24881594 PMID:26751814 PMID:31794810 More...
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adcy5 |
adenylate cyclase 5 |
increases response to substance |
ISO |
ADCY5 protein results in increased susceptibility to Atropine |
CTD |
PMID:12869393 |
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NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Aqp5 |
aquaporin 5 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] |
CTD |
PMID:26208470 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] |
CTD |
PMID:21971501 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcar1 |
BCAR1 scaffold protein, Cas family member |
multiple interactions |
ISO |
Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] |
CTD |
PMID:10537051 |
|
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
|
|
G |
Bche |
butyrylcholinesterase |
multiple interactions |
EXP ISO |
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein [BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX |
CTD |
PMID:17963125 PMID:22981459 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
|
|
G |
Bdkrb2 |
bradykinin receptor B2 |
multiple interactions |
ISO |
BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] |
CTD |
PMID:10614985 |
|
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
|
|
G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] |
CTD |
PMID:18472332 |
|
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
|
|
G |
Cacna1e |
calcium voltage-gated channel subunit alpha1 E |
multiple interactions |
EXP |
Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] |
CTD |
PMID:12663092 |
|
NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
|
|
G |
Calca |
calcitonin-related polypeptide alpha |
affects activity |
EXP |
Atropine affects the activity of CALCA protein |
CTD |
PMID:7906887 PMID:10075105 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
|
|
G |
Casp3 |
caspase 3 |
increases expression |
EXP |
Atropine results in increased expression of CASP3 mRNA |
CTD |
PMID:19815060 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] |
CTD |
PMID:22245128 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Ccna1 |
cyclin A1 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA Atropine results in increased expression of CCNA1 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
|
|
G |
Ccnd3 |
cyclin D3 |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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|
G |
Ccne1 |
cyclin E1 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA Atropine results in increased expression of CCNE1 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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|
G |
Ccne2 |
cyclin E2 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CCNE2 mRNA [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
|
|
G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] |
CTD |
PMID:16879495 |
|
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
|
|
G |
Cdc20 |
cell division cycle 20 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CDC20 mRNA [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
|
|
G |
Cdc6 |
cell division cycle 6 |
multiple interactions |
ISO |
[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of CDK1 mRNA [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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|
G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] |
CTD |
PMID:9311626 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions decreases activity |
ISO |
Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein] Atropine results in decreased activity of CHRM1 protein |
CTD |
PMID:16439611 PMID:18316702 PMID:31830555 |
|
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
|
|
G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
ISO |
Atropine binds to and results in decreased activity of CHRM2 protein |
CTD |
PMID:15140916 |
|
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
|
|
G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions decreases activity |
ISO |
Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein] Atropine results in decreased activity of CHRM3 protein |
CTD |
PMID:15140916 PMID:20708676 PMID:31830555 |
|
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
affects binding multiple interactions |
ISO |
Atropine binds to CHRM4 protein [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] |
CTD |
PMID:16709648 |
|
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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G |
Chrm5 |
cholinergic receptor, muscarinic 5 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] |
CTD |
PMID:31323226 |
|
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
|
|
G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions affects binding |
ISO EXP |
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]] Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] |
CTD |
PMID:15733544 PMID:21791372 |
|
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
|
|
G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
affects binding multiple interactions |
ISO EXP |
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]] |
CTD |
PMID:15733544 PMID:21791372 |
|
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] |
CTD |
PMID:21971501 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
|
|
G |
Crh |
corticotropin releasing hormone |
multiple interactions |
ISO EXP |
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein] |
CTD |
PMID:12039681 PMID:12906840 |
|
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] |
CTD |
PMID:17390078 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] |
CTD |
PMID:22245128 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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|
G |
Dvl2 |
dishevelled segment polarity protein 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] |
CTD |
PMID:17390078 |
|
NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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|
G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] |
CTD |
PMID:12906840 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] |
CTD |
PMID:17390078 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Egr1 |
early growth response 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] |
CTD |
PMID:7968354 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
|
|
G |
Egr2 |
early growth response 2 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] |
CTD |
PMID:7968354 |
|
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
|
|
G |
Ezr |
ezrin |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] |
CTD |
PMID:17390078 |
|
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
|
|
G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein |
CTD |
PMID:30515700 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
|
|
G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein |
CTD |
PMID:30515700 |
|
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP ISO |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] Atropine results in increased expression of FOS protein Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA] |
CTD |
PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
EXP |
Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] |
CTD |
PMID:16959836 |
|
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
|
|
G |
Glra1 |
glycine receptor, alpha 1 |
multiple interactions |
ISO |
Atropine binds to and results in decreased activity of GLRA1 protein |
CTD |
PMID:15081878 |
|
NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
|
|
G |
Grm4 |
glutamate metabotropic receptor 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
|
NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] |
CTD |
PMID:22245128 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] |
CTD |
PMID:22245128 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] |
CTD |
PMID:22245128 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] |
CTD |
PMID:21971501 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] |
CTD |
PMID:7968354 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
|
|
G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
multiple interactions |
ISO |
Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
|
NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
|
|
G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] |
CTD |
PMID:17390078 |
|
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
|
|
G |
Ltf |
lactotransferrin |
multiple interactions |
ISO |
Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] |
CTD |
PMID:11112886 |
|
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21971501 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:21971501 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21971501 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:21971501 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mcm4 |
minichromosome maintenance complex component 4 |
multiple interactions increases expression |
ISO |
[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA Atropine results in increased expression of MCM4 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
|
|
G |
Mcm6 |
minichromosome maintenance complex component 6 |
increases expression multiple interactions |
ISO |
Atropine results in increased expression of MCM6 mRNA [Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA |
CTD |
PMID:17390078 |
|
NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
|
|
G |
Nefh |
neurofilament heavy chain |
affects expression |
EXP |
Atropine affects the expression of NEFH mRNA |
CTD |
PMID:22954530 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Atropine results in increased expression of NLRP3 mRNA |
CTD |
PMID:28138970 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] |
CTD |
PMID:15610444 PMID:16944022 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Notch4 |
notch receptor 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] |
CTD |
PMID:17390078 |
|
NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
|
|
G |
Nppa |
natriuretic peptide A |
affects activity |
EXP |
Atropine affects the activity of NPPA protein modified form |
CTD |
PMID:1363893 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
G |
Oprl1 |
opioid related nociceptin receptor 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] |
CTD |
PMID:12007927 |
|
NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] |
CTD |
PMID:12762645 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pnoc |
prepronociceptin |
multiple interactions |
EXP |
Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] |
CTD |
PMID:12007927 |
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NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] |
CTD |
PMID:7588217 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] |
CTD |
PMID:18812576 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] |
CTD |
PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[Wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[Wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Wortmannin] results in increased phosphorylation of PTK2 protein]] |
CTD |
PMID:10537051 |
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NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G |
Pxn |
paxillin |
multiple interactions |
ISO |
Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] |
CTD |
PMID:10537051 |
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NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
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G |
Rac3 |
Rac family small GTPase 3 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] |
CTD |
PMID:17390078 |
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NCBI chr10:106,002,808...106,005,243
Ensembl chr10:105,993,087...106,005,260
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] |
CTD |
PMID:21971501 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] |
CTD |
PMID:17390078 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:16263091 PMID:21641380 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:16263091 PMID:21599003 PMID:23770354 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions increases uptake |
ISO |
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] SLC22A3 protein results in increased uptake of Atropine |
CTD |
PMID:16263091 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Atropine results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] |
CTD |
PMID:22245128 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Spn |
sialophorin |
increases response to substance |
ISO |
SPN protein results in increased susceptibility to Atropine |
CTD |
PMID:18711009 |
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NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] |
CTD |
PMID:7761789 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] |
CTD |
PMID:18472332 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] |
CTD |
PMID:22245128 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] |
CTD |
PMID:12762645 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trio |
trio Rho guanine nucleotide exchange factor |
multiple interactions |
ISO |
Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] |
CTD |
PMID:17390078 |
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NCBI chr 2:78,505,069...78,801,384
Ensembl chr 2:78,505,070...78,803,135
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
decreases response to substance |
ISO |
TRPA1 gene mutant form results in decreased susceptibility to Atropine |
CTD |
PMID:29627347 |
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NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
EXP |
[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] |
CTD |
PMID:15891268 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Tspo |
translocator protein |
multiple interactions |
EXP |
[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein |
CTD |
PMID:33823148 |
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NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] |
CTD |
PMID:22245128 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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