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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrimidopyrimidine
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Accession:CHEBI:48514 term browser browse the term
Definition:An organic heterobicyclic compound with a skeleton consisting of two pyrimidine rings that are ortho-fused to each other at any position.
Synonyms:related_synonym: pyrimidopyrimidines


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dipyridamole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Dipyridamole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Dipyridamole results in decreased activity of ABCB11 protein		 CTD PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity
multiple interactions		 ISO Dipyridamole results in decreased activity of ABCC4 protein
Dipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]		 CTD PMID:11856762 PMID:15827327 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Adora3 adenosine A3 receptor increases expression EXP Dipyridamole results in increased expression of ADORA3 protein CTD PMID:17101059 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] CTD PMID:20063052 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp1 caspase 1 increases activity EXP Dipyridamole results in increased activity of CASP1 protein CTD PMID:21832250 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] CTD PMID:17303086 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Dipyridamole results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] CTD PMID:17303086 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO		 Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]		 CTD PMID:16765938 PMID:20940016 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd40lg CD40 ligand decreases secretion ISO Dipyridamole results in decreased secretion of CD40LG protein CTD PMID:16046616 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] CTD PMID:17303086 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cldn5 claudin 5 increases expression ISO Dipyridamole results in increased expression of CLDN5 mRNA CTD PMID:20711499 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 ISO
EXP		 Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
Dipyridamole results in decreased expression of COL1A1 mRNA		 CTD PMID:7617123 PMID:11576339 PMID:12271277 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Dipyridamole results in decreased expression of CXCL12 mRNA CTD PMID:20711499 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] CTD PMID:20063052 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases phosphorylation
multiple interactions		 ISO
EXP		 Dipyridamole results in increased phosphorylation of DUSP1 protein
DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]		 CTD PMID:16765938 PMID:19356721 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Dipyridamole results in decreased expression of ENPP1 protein CTD PMID:21414308 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Fadd Fas associated via death domain increases expression
multiple interactions		 ISO Dipyridamole results in increased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]		 CTD PMID:17303086 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Dipyridamole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP Dipyridamole results in increased expression of HMOX1 protein
HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]		 CTD PMID:19356721 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Dipyridamole results in decreased expression of ICAM1 mRNA CTD PMID:20711499 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein] CTD PMID:16765938 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]; KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]; KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Dipyridamole results in decreased expression of IL2 mRNA CTD PMID:20711499 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:16765938 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insr insulin receptor multiple interactions ISO Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] CTD PMID:15694368 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dipyridamole results in decreased activity of KCNH2 protein CTD PMID:17146843 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lep leptin multiple interactions
increases expression		 EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO Dipyridamole results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:16765938 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Dipyridamole results in increased expression of NOS2 mRNA; Dipyridamole results in increased expression of NOS2 protein
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:8904084 PMID:12271277 PMID:16765938 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO Dipyridamole results in increased expression of NPPB protein CTD PMID:18037770 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding		 ISO Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
Dipyridamole binds to ORM1 protein alternative form		 CTD PMID:8946472 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pde10a phosphodiesterase 10A multiple interactions ISO Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:10373451 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde11a phosphodiesterase 11A multiple interactions ISO Dipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:10725373 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Dipyridamole results in increased expression of PDE4B mRNA CTD PMID:20711499 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Dipyridamole results in decreased activity of PDE5A protein CTD PMID:11051267 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Dipyridamole inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Dipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 PMID:10814504 PMID:10872825 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900 		JBrowse link
G Pde8a phosphodiesterase 8A multiple interactions ISO Dipyridamole inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP]
Dipyridamole inhibits the reaction [PDE8A protein results in increased hydrolysis of Cyclic AMP]		 CTD PMID:9671792 PMID:12681444 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pde8b phosphodiesterase 8B multiple interactions ISO Dipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] CTD PMID:9784418 PMID:12681444 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Plat plasminogen activator, tissue type increases secretion
multiple interactions		 ISO Dipyridamole results in increased secretion of PLAT protein
KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein]		 CTD PMID:15733978 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP		 Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; triptolide inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]		 CTD PMID:16765938 PMID:20940016 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rcan1 regulator of calcineurin 1 affects binding ISO Dipyridamole binds to RCAN1 protein alternative form CTD PMID:19189965 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dipyridamole inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Dipyridamole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions
decreases activity		 ISO Dipyridamole inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
Dipyridamole results in decreased activity of SLC29A1 protein
Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]		 CTD PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 PMID:11179696 More... NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
Dipyridamole inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]		 CTD PMID:10366666 PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Dipyridamole inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions ISO Dipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides] CTD PMID:2511191 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]; Dipyridamole inhibits the reaction [Glucose results in increased expression of SPP1 mRNA]; Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]] CTD PMID:19356721 PMID:20453393 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Dipyridamole results in decreased expression of TH protein CTD PMID:17568153 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Dipyridamole results in decreased expression of TNF mRNA CTD PMID:20711499 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Dipyridamole metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Dipyridamole inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] CTD PMID:30237061 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Dipyridamole results in decreased expression of VCAM1 mRNA CTD PMID:20711499 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
multiple interactions		 ISO Dipyridamole results in increased secretion of VEGFA protein
Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]		 CTD PMID:20067761 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  pyrimidopyrimidine 61
                    1-(4-fluorophenyl)-7-(4-methylphenyl)-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione 0
                    7-amino-1-methyl-3-[2-methyl-5-(\{[3-(trifluoromethyl)phenyl]carbonyl\}amino)phenyl]-2-oxo-2,3-dihydropyrimido[4,5-d]pyrimidin-1-ium 0
                    dipyridamole 61
                    pluripotin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      p-block molecular entity 19817
                        carbon group molecular entity 19757
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      pyrimidopyrimidine 61
                                        1-(4-fluorophenyl)-7-(4-methylphenyl)-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione 0
                                        7-amino-1-methyl-3-[2-methyl-5-(\{[3-(trifluoromethyl)phenyl]carbonyl\}amino)phenyl]-2-oxo-2,3-dihydropyrimido[4,5-d]pyrimidin-1-ium 0
                                        dipyridamole 61
                                        pluripotin 0
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