CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: erythromycin estolate
Accession: CHEBI:4846
browse the term
Definition: An erythromycin derivative that has formula C40H71NO14.C12H26O4S.
Synonyms: exact_synonym: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-6-[3,4,6-trideoxy-3-(dimethylamino)-2-O-propanoyl-beta-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione dodecyl hydrogen sulfate
related_synonym: Eriscel; Eritroger; Eromycin; Erythromycin estorate; Estomicina; Formula=C40H71NO14.C12H26O4S; Ilosone; InChI=1S/C40H71NO14.C12H26O4S/c1-15-27-40(11,48)33(44)22(5)30(43)20(3)18-38(9,47)35(55-37-32(53-28(42)16-2)26(41(12)13)17-21(4)50-37)23(6)31(24(7)36(46)52-27)54-29-19-39(10,49-14)34(45)25(8)51-29;1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15/h20-27,29,31-35,37,44-45,47-48H,15-19H2,1-14H3;2-12H2,1H3,(H,13,14,15)/t20-,21-,22+,23+,24-,25+,26+,27-,29+,31+,32-,33-,34+,35-,37+,38-,39-,40-;/m1./s1; InChIKey=AWMFUEJKWXESNL-JZBHMOKNSA-N; Lauromicina; Marcoeritrex; Neo-erycinum; PELS; Roxomicina; SMILES=CCCCCCCCCCCCOS(O)(=O)=O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2OC(=O)CC)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O; Stellamicina; erythromycin 2'-propionate dodecyl sulfate (salt); erythromycin propionate, compound with dodecyl sulfate; lauryl sulfate propionyl erythromycin ester; monopropionylerythromycin laurylsulfate; propionic acid, 2'-ester with erythromycin, dodecyl sulfate; propionylerythromycin lauryl sulfate
xref: Beilstein:3897327; CAS:3521-62-8; KEGG:C08031; KEGG:D00851; LIPID_MAPS_instance:LMPK04000015
xref_mesh: MESH:D004918
xref: Patent:US3000874
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression decreases activity
EXP ISO
Erythromycin Estolate results in decreased expression of ABCB11 mRNA Erythromycin Estolate results in decreased activity of ABCB11 protein
CTD
PMID:17522070 PMID:20829430 PMID:23956101 PMID:28437613
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
EXP
Erythromycin Estolate results in increased expression of ABCB1 mRNA; Erythromycin Estolate results in increased expression of ABCB1A mRNA
CTD
PMID:17522070 PMID:24412560
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Erythromycin Estolate results in increased expression of ABCC3 mRNA
CTD
PMID:17522070 PMID:24412560
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg5
ATP binding cassette subfamily G member 5
increases expression
EXP
Erythromycin Estolate results in increased expression of ABCG5 mRNA
CTD
PMID:24412560
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Abcg8
ATP binding cassette subfamily G member 8
increases expression
EXP
Erythromycin Estolate results in increased expression of ABCG8 mRNA
CTD
PMID:24412560
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Acadm
acyl-CoA dehydrogenase medium chain
decreases expression
EXP
Erythromycin Estolate results in decreased expression of ACADM mRNA
CTD
PMID:17522070
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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Acly
ATP citrate lyase
decreases expression
EXP
Erythromycin Estolate results in decreased expression of ACLY mRNA
CTD
PMID:17522070
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of ACSL1 mRNA
CTD
PMID:17522070
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
Erythromycin Estolate results in increased expression of ALDH1A1 mRNA
CTD
PMID:24412560
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh3a2
aldehyde dehydrogenase 3 family, member A2
decreases expression
EXP
Erythromycin Estolate results in decreased expression of ALDH3A2 mRNA
CTD
PMID:17522070
NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of APEX1 mRNA
CTD
PMID:17522070
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Aspm
assembly factor for spindle microtubules
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of ASPM mRNA Erythromycin Estolate results in increased expression of ASPM mRNA
CTD
PMID:24412560
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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Aurkb
aurora kinase B
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of AURKB mRNA Erythromycin Estolate results in decreased expression of AURKB mRNA
CTD
PMID:24412560
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Bax
BCL2 associated X, apoptosis regulator
decreases expression
EXP
Erythromycin Estolate results in decreased expression of BAX mRNA
CTD
PMID:12883083
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Erythromycin Estolate results in increased expression of BCL2 mRNA
CTD
PMID:12883083
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Btg2
BTG anti-proliferation factor 2
increases expression
EXP
Erythromycin Estolate results in increased expression of BTG2 mRNA
CTD
PMID:17522070
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Cacna1i
calcium voltage-gated channel subunit alpha1 I
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CACNA1I mRNA
CTD
PMID:24412560
NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
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Calu
calumenin
increases expression
EXP
Erythromycin Estolate results in increased expression of CALU mRNA
CTD
PMID:17522070
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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Car1
carbonic anhydrase 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CAR1 mRNA
CTD
PMID:24412560
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Cat
catalase
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CAT mRNA
CTD
PMID:17522070
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccn2
cellular communication network factor 2
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CCN2 mRNA
CTD
PMID:24412560
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccna2
cyclin A2
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of CCNA2 mRNA Erythromycin Estolate results in decreased expression of CCNA2 mRNA
CTD
PMID:24412560
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of CCNB1 mRNA Erythromycin Estolate results in increased expression of CCNB1 mRNA
CTD
PMID:24412560
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdca3
cell division cycle associated 3
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of CDCA3 mRNA Erythromycin Estolate results in increased expression of CDCA3 mRNA
CTD
PMID:24412560
NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
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Cdk1
cyclin-dependent kinase 1
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of CDK1 mRNA Erythromycin Estolate results in decreased expression of CDK1 mRNA
CTD
PMID:24412560
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Ceacam1
CEA cell adhesion molecule 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CEACAM1 mRNA
CTD
PMID:17522070
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Cenpw
centromere protein W
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of CENPW mRNA Erythromycin Estolate results in decreased expression of CENPW mRNA
CTD
PMID:24412560
NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464
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Ces2h
carboxylesterase 2H
increases expression
EXP
Erythromycin Estolate results in increased expression of CES2 mRNA
CTD
PMID:24412560
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Chd2
chromodomain helicase DNA binding protein 2
increases expression
EXP
Erythromycin Estolate results in increased expression of CHD2 mRNA
CTD
PMID:24412560
NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502
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Ctsl
cathepsin L
increases expression
EXP
Erythromycin Estolate results in increased expression of CTSL mRNA
CTD
PMID:17522070
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cyb5r3
cytochrome b5 reductase 3
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CYB5R3 mRNA
CTD
PMID:17522070
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
Erythromycin Estolate results in increased expression of CYP1A1 mRNA
CTD
PMID:24412560
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2d3
cytochrome P450, family 2, subfamily d, polypeptide 3
decreases expression
EXP
Erythromycin Estolate results in decreased expression of CYP2D3 mRNA
CTD
PMID:17522070
NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Erythromycin Estolate results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:12883083
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
EXP
Erythromycin Estolate results in increased expression of CYP3A9 mRNA
CTD
PMID:24412560
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
increases expression
EXP
Erythromycin Estolate results in increased expression of CYP8B1 mRNA
CTD
PMID:24412560
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
Erythromycin Estolate results in increased expression of DDIT3 mRNA
CTD
PMID:17522070
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dut
deoxyuridine triphosphatase
increases expression
EXP
Erythromycin Estolate results in increased expression of DUT mRNA
CTD
PMID:24412560
NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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Ect2
epithelial cell transforming 2
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of ECT2 mRNA Erythromycin Estolate results in increased expression of ECT2 mRNA
CTD
PMID:24412560
NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
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Fabp1
fatty acid binding protein 1
increases expression
EXP
Erythromycin Estolate results in increased expression of FABP1 mRNA
CTD
PMID:17522070
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fads1
fatty acid desaturase 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of FADS1 mRNA
CTD
PMID:17522070
NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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Fam111a
FAM111 trypsin like peptidase A
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of FAM111A mRNA Erythromycin Estolate results in decreased expression of FAM111A mRNA
CTD
PMID:24412560
NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547
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Fasn
fatty acid synthase
decreases expression
EXP
Erythromycin Estolate results in decreased expression of FASN mRNA
CTD
PMID:17522070
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fga
fibrinogen alpha chain
increases expression
EXP
Erythromycin Estolate results in increased expression of FGA mRNA
CTD
PMID:17522070
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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Fgb
fibrinogen beta chain
increases expression
EXP
Erythromycin Estolate results in increased expression of FGB mRNA
CTD
PMID:17522070
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of FMO1 mRNA
CTD
PMID:17522070
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of G6PC1 mRNA
CTD
PMID:24412560
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Erythromycin Estolate results in increased expression of GADD45A mRNA
CTD
PMID:17522070
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gck
glucokinase
decreases expression
EXP
Erythromycin Estolate results in decreased expression of GCK mRNA
CTD
PMID:17522070
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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Gpx1
glutathione peroxidase 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of GPX1 mRNA
CTD
PMID:17522070
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gpx2
glutathione peroxidase 2
increases expression
EXP
Erythromycin Estolate results in increased expression of GPX2 mRNA
CTD
PMID:24412560
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gstm5
glutathione S-transferase, mu 5
decreases expression
EXP
Erythromycin Estolate results in decreased expression of GSTM3 mRNA
CTD
PMID:17522070
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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Hibadh
3-hydroxyisobutyrate dehydrogenase
decreases expression
EXP
Erythromycin Estolate results in decreased expression of HIBADH mRNA
CTD
PMID:17522070
NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
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Hmmr
hyaluronan-mediated motility receptor
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of HMMR mRNA Erythromycin Estolate results in decreased expression of HMMR mRNA
CTD
PMID:24412560
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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Igf2r
insulin-like growth factor 2 receptor
increases expression
EXP
Erythromycin Estolate results in increased expression of IGF2R mRNA
CTD
PMID:24412560
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP
Erythromycin Estolate results in increased expression of IGFBP1 mRNA
CTD
PMID:17522070
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
Erythromycin Estolate results in increased expression of IGFBP2 mRNA
CTD
PMID:24412560
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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Ip6k2
inositol hexakisphosphate kinase 2
decreases expression
EXP
Erythromycin Estolate results in decreased expression of IP6K2 mRNA
CTD
PMID:24412560
NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
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Isy1
ISY1 splicing factor homolog
increases expression
EXP
Erythromycin Estolate results in increased expression of ISY1 mRNA
CTD
PMID:24412560
NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188
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Kif20b
kinesin family member 20B
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of KIF20B mRNA Erythromycin Estolate results in decreased expression of KIF20B mRNA
CTD
PMID:24412560
NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
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Kif23
kinesin family member 23
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of KIF23 mRNA Erythromycin Estolate results in decreased expression of KIF23 mRNA
CTD
PMID:24412560
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
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Kif2c
kinesin family member 2C
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of KIF2C mRNA Erythromycin Estolate results in increased expression of KIF2C mRNA
CTD
PMID:24412560
NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
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Krt18
keratin 18
increases expression
EXP
Erythromycin Estolate results in increased expression of KRT18 mRNA
CTD
PMID:17522070
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 Ensembl chr10:133,157,475...133,161,166
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Lbp
lipopolysaccharide binding protein
increases expression
EXP
Erythromycin Estolate results in increased expression of LBP mRNA
CTD
PMID:17522070
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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Lgals3
galectin 3
increases expression
EXP
Erythromycin Estolate results in increased expression of LGALS3 mRNA
CTD
PMID:17522070
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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Lipc
lipase C, hepatic type
decreases expression
EXP
Erythromycin Estolate results in decreased expression of LIPC mRNA
CTD
PMID:17522070
NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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Lpin1
lipin 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of LPIN1 mRNA
CTD
PMID:24412560
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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Lpl
lipoprotein lipase
increases expression
EXP
Erythromycin Estolate results in increased expression of LPL mRNA
CTD
PMID:17522070
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Maob
monoamine oxidase B
decreases expression
EXP
Erythromycin Estolate results in decreased expression of MAOB mRNA
CTD
PMID:17522070
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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Mir16
microRNA 16
increases expression
EXP
Erythromycin Estolate results in increased expression of MIR16 mRNA
CTD
PMID:17522070
NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of MYC mRNA Erythromycin Estolate results in decreased expression of MYC mRNA
CTD
PMID:17522070 PMID:24412560
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Ncaph
non-SMC condensin I complex, subunit H
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of NCAPH mRNA Erythromycin Estolate results in increased expression of NCAPH mRNA
CTD
PMID:24412560
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
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Nfkbib
NFKB inhibitor beta
decreases expression
EXP
Erythromycin Estolate results in decreased expression of NFKBIB mRNA
CTD
PMID:17522070
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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Noct
nocturnin
decreases expression
EXP
Erythromycin Estolate results in decreased expression of NOCT mRNA
CTD
PMID:24412560
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Nusap1
nucleolar and spindle associated protein 1
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of NUSAP1 mRNA Erythromycin Estolate results in decreased expression of NUSAP1 mRNA
CTD
PMID:24412560
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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Obp3
alpha-2u globulin PGCL4
decreases expression
EXP
Erythromycin Estolate results in decreased expression of OBP3 mRNA
CTD
PMID:24412560
NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
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Otc
ornithine transcarbamylase
decreases expression
EXP
Erythromycin Estolate results in decreased expression of OTC mRNA
CTD
PMID:17522070
NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
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Pclaf
PCNA clamp associated factor
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of PCLAF mRNA Erythromycin Estolate results in decreased expression of PCLAF mRNA
CTD
PMID:24412560
NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
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Pcmtd1
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of PCMTD1 mRNA
CTD
PMID:24412560
NCBI chr 5:12,284,711...12,355,680
Ensembl chr 5:12,284,711...12,354,899
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Pdk4
pyruvate dehydrogenase kinase 4
decreases expression
EXP
Erythromycin Estolate results in decreased expression of PDK4 mRNA
CTD
PMID:24412560
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Per1
period circadian regulator 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of PER1 mRNA
CTD
PMID:24412560
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
decreases expression
EXP
Erythromycin Estolate results in decreased expression of PFKFB3 mRNA
CTD
PMID:24412560
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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Pklr
pyruvate kinase L/R
decreases expression
EXP
Erythromycin Estolate results in decreased expression of PKLR mRNA
CTD
PMID:17522070
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Pygl
glycogen phosphorylase L
decreases expression
EXP
Erythromycin Estolate results in decreased expression of PYGL mRNA
CTD
PMID:17522070
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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Rad51
RAD51 recombinase
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of RAD51 mRNA Erythromycin Estolate results in decreased expression of RAD51 mRNA
CTD
PMID:24412560
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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Rrm2
ribonucleotide reductase regulatory subunit M2
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of RRM2 mRNA Erythromycin Estolate results in increased expression of RRM2 mRNA
CTD
PMID:24412560
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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S100a8
S100 calcium binding protein A8
increases expression
EXP
Erythromycin Estolate results in increased expression of S100A8 mRNA
CTD
PMID:17522070
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9
S100 calcium binding protein A9
increases expression
EXP
Erythromycin Estolate results in increased expression of S100A9 mRNA
CTD
PMID:17522070
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Serpina7
serpin family A member 7
increases expression
EXP
Erythromycin Estolate results in increased expression of SERPINA7 mRNA
CTD
PMID:24412560
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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Sertad3
SERTA domain containing 3
increases expression
EXP
Erythromycin Estolate results in increased expression of SERTAD3 mRNA
CTD
PMID:24412560
NCBI chr 1:82,763,535...82,767,271
Ensembl chr 1:82,763,149...82,769,001
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Shcbp1
SHC binding and spindle associated 1
decreases expression increases expression
EXP
Erythromycin Estolate results in decreased expression of SHCBP1 mRNA Erythromycin Estolate results in increased expression of SHCBP1 mRNA
CTD
PMID:24412560
NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844
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Slc38a2
solute carrier family 38, member 2
decreases expression
EXP
Erythromycin Estolate results in decreased expression of SLC38A2 mRNA
CTD
PMID:24412560
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression
EXP
Erythromycin Estolate results in increased expression of SLCO1A4 mRNA
CTD
PMID:24412560
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2
solute carrier organic anion transporter family member 1B2
decreases expression
EXP
Erythromycin Estolate results in decreased expression of SLCO1B2 mRNA
CTD
PMID:17522070
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Spc25
SPC25 component of NDC80 kinetochore complex
increases expression decreases expression
EXP
Erythromycin Estolate results in increased expression of SPC25 mRNA Erythromycin Estolate results in decreased expression of SPC25 mRNA
CTD
PMID:24412560
NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
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Spin2b
spindlin family member 2B
decreases expression
EXP
Erythromycin Estolate results in decreased expression of SPIN2B mRNA
CTD
PMID:17522070
NCBI chr X:17,190,573...17,192,351
Ensembl chr X:17,180,474...17,192,351
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Spink1
serine peptidase inhibitor, Kazal type 1
increases expression
EXP
Erythromycin Estolate results in increased expression of SPINK1 mRNA
CTD
PMID:24412560
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of SREBF1 mRNA
CTD
PMID:17522070
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Erythromycin Estolate results in increased expression of STAT3 mRNA
CTD
PMID:17522070
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Styxl1
serine/threonine/tyrosine interacting-like 1
increases expression
EXP
Erythromycin Estolate results in increased expression of STYXL1 mRNA
CTD
PMID:24412560
NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752
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Sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
increases expression
EXP
Erythromycin Estolate results in increased expression of SUGT1 mRNA
CTD
PMID:24412560
NCBI chr15:54,991,419...55,032,244
Ensembl chr15:54,990,672...55,069,150
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Tgfb3
transforming growth factor, beta 3
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TGFB3 mRNA
CTD
PMID:24412560
NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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Thrsp
thyroid hormone responsive
decreases expression
EXP
Erythromycin Estolate results in decreased expression of THRSP mRNA
CTD
PMID:17522070
NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Erythromycin Estolate results in increased expression of TIMP1 mRNA
CTD
PMID:17522070
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tmcc1
transmembrane and coiled-coil domain family 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TMCC1 mRNA
CTD
PMID:24412560
NCBI chr 4:149,069,252...149,239,585
Ensembl chr 4:149,069,260...149,239,620
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Tnfaip3
TNF alpha induced protein 3
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TNFAIP3 mRNA
CTD
PMID:24412560
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
EXP
Erythromycin Estolate results in increased expression of TNFRSF1A mRNA
CTD
PMID:17522070
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tp53
tumor protein p53
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TP53 mRNA
CTD
PMID:17522070
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tsc22d3
TSC22 domain family, member 3
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TSC22D3 mRNA
CTD
PMID:24412560
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
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Ttr
transthyretin
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TTR mRNA
CTD
PMID:17522070
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Txnrd1
thioredoxin reductase 1
decreases expression
EXP
Erythromycin Estolate results in decreased expression of TXNRD1 mRNA
CTD
PMID:17522070
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ugt2a1
UDP glucuronosyltransferase family 2 member A1
increases expression
EXP
Erythromycin Estolate results in increased expression of UGT2A1 mRNA
CTD
PMID:24412560
NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531
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Zc3h13
zinc finger CCCH type containing 13
increases expression
EXP
Erythromycin Estolate results in increased expression of ZC3H13 mRNA
CTD
PMID:24412560
NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
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Zfp354a
zinc finger protein 354A
decreases expression
EXP
Erythromycin Estolate results in decreased expression of ZFP354A mRNA
CTD
PMID:24412560
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
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Zfp574
zinc finger protein 574
increases expression
EXP
Erythromycin Estolate results in increased expression of ZFP574 mRNA
CTD
PMID:24412560
NCBI chr 1:80,667,984...80,678,257
Ensembl chr 1:80,664,259...80,679,427
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