EC 2.1.1.6 (catechol O-methyltransferase) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	EC 2.1.1.6 (catechol O-methyltransferase) inhibitor	go back to main search page
Accession:	CHEBI:48406	browse the term
Definition:	An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).
Synonyms:	related_synonym:	COMT inhibitor; COMT inhibitors; EC 2.1.1.6 inhibitor; EC 2.1.1.6 inhibitors; S-adenosyl-L-methionine:catechol O-methyltransferase inhibitor; S-adenosyl-L-methionine:catechol O-methyltransferase inhibitors; catechol O-methyltransferase (EC 2.1.1.6) inhibitors; catechol O-methyltransferase inhibitor; catechol O-methyltransferase inhibitors; catechol methyltransferase inhibitor; catechol methyltransferase inhibitors; catecholamine O-methyltransferase inhibitor; catecholamine O-methyltransferase inhibitors
	xref:	Wikipedia:Catechol_O-methyltransferase

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Genes (353)

entacapone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 3, pristanoyl

affects binding

entacapone binds to ACOX3 protein

NCBI chr14:79,358,604...79,405,160
Ensembl chr14:75,094,676...75,176,205

G

acyl-CoA synthetase long-chain family member 1

affects binding

entacapone binds to ACSL1 protein

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541

G

ADP-ribosylhydrolase like 1

affects binding

entacapone binds to ADPRHL1 protein

NCBI chr16:82,985,355...83,017,240
Ensembl chr16:76,283,103...76,354,440

G

AU RNA binding methylglutaconyl-CoA hydratase

affects binding

entacapone binds to AUH protein

NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,329,524...12,424,896

G

clathrin heavy chain

affects binding

entacapone binds to CLTC protein

NCBI chr10:72,014,984...72,073,308
Ensembl chr10:71,517,663...71,573,737

G

catechol-O-methyltransferase

decreases activity
affects binding
multiple interactions

entacapone results in decreased activity of COMT protein
entacapone binds to COMT protein
[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]

PMID:12898346 PMID:15566291 PMID:19783845 PMID:20334432 PMID:23206800 More...

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

enoyl-CoA hydratase, short chain 1

affects binding

entacapone binds to ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:194,895,036...194,903,884

G

epiregulin

increases expression

entacapone results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,027,287...17,041,062

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

entacapone results in decreased expression of GPAM protein

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:254,106,331...254,142,639

G

hemoglobin subunit beta

affects binding

entacapone binds to HBB protein

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012

G

hydroxysteroid (17-beta) dehydrogenase 13

affects binding

entacapone binds to HSD17B13 protein

NCBI chr14:6,056,708...6,071,463
Ensembl chr14:5,752,132...5,768,166

G

hydroxysteroid (17-beta) dehydrogenase 4

affects binding

entacapone binds to HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952

G

interleukin 1 alpha

increases expression

entacapone results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

entacapone results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

entacapone results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

pyruvate carboxylase

affects binding

entacapone binds to PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380

G

phosphotyrosine interaction domain containing 1

decreases expression

entacapone results in decreased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

increases expression

entacapone results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 7 member 11

decreases expression

entacapone results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

decreases expression

entacapone results in decreased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

synuclein alpha

multiple interactions

entacapone inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262

G

sulfotransferase family 2A member 1

affects binding

entacapone binds to SULT2A1 protein

NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134

G

TNF alpha induced protein 6

decreases expression

entacapone results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:36,502,188...36,521,649

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of entacapone

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of entacapone

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation
decreases glucuronidation

UGT1A9 protein results in increased glucuronidation of entacapone
UGT1A9 protein mutant form results in decreased glucuronidation of entacapone

PMID:15044611 PMID:15802387 PMID:16344532

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

tolcapone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arylacetamide deacetylase

decreases expression

tolcapone results in decreased expression of AADAC mRNA

NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:144,135,319...144,174,734

G

alanyl-tRNA synthetase 1

increases expression

Tolcapone results in increased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

decreases activity

tolcapone results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily D member 2

affects binding

tolcapone binds to ABCD2 protein

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:122,263,032...122,311,642

G

abhydrolase domain containing 10, depalmitoylase

affects binding

tolcapone binds to ABHD10 protein

NCBI chr11:68,543,860...68,556,059
Ensembl chr11:55,081,049...55,107,866

G

acetyl-CoA acetyltransferase 2

increases expression

tolcapone results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA oxidase 3, pristanoyl

affects binding

tolcapone binds to ACOX3 protein

NCBI chr14:79,358,604...79,405,160
Ensembl chr14:75,094,676...75,176,205

G

acyl-CoA synthetase long-chain family member 1

affects binding
decreases expression

tolcapone binds to ACSL1 protein
tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein

PMID:19783845 PMID:29688484

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 5

decreases expression

tolcapone results in decreased expression of ACSL5 protein

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase short-chain family member 2

increases expression

tolcapone results in increased expression of ACSS2 mRNA

NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:144,004,336...144,059,675

G

actin alpha 2, smooth muscle

affects binding

tolcapone binds to ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

ADP-ribosylhydrolase like 1

affects binding

tolcapone binds to ADPRHL1 protein

NCBI chr16:82,985,355...83,017,240
Ensembl chr16:76,283,103...76,354,440

G

aspartylglucosaminidase

decreases expression

tolcapone results in decreased expression of AGA mRNA

NCBI chr16:45,191,215...45,249,537
Ensembl chr16:38,504,663...38,516,606

G

allograft inflammatory factor 1

decreases expression

tolcapone results in decreased expression of AIF1 mRNA

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668

G

adenylate kinase 2

affects binding

tolcapone binds to AK2 protein

NCBI chr 5:146,609,469...146,649,008
Ensembl chr 5:141,346,063...141,364,632

G

aldo-keto reductase family 1, member C1

affects binding

Tolcapone binds to AKR1C1 protein

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C3

decreases expression

tolcapone results in decreased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 1, member D1

affects binding

tolcapone binds to AKR1D1 protein

NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:66,154,248...66,186,372

G

aldehyde dehydrogenase 18 family, member A1

affects binding

tolcapone binds to ALDH18A1 protein

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member B1

affects binding

tolcapone binds to ALDH1B1 protein

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 1 family, member L1

increases expression

tolcapone results in increased expression of ALDH1L1 mRNA

NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:123,060,008...123,106,465

G

aldehyde dehydrogenase 3 family, member A2

affects binding

tolcapone binds to ALDH3A2 protein

NCBI chr10:46,427,789...46,448,449
Ensembl chr10:45,908,524...45,949,281

G

ALG13, UDP-N-acetylglucosaminyltransferase subunit

decreases expression

Tolcapone results in decreased expression of ALG13 mRNA

NCBI chr X:112,703,015...112,764,924
Ensembl chr X:107,885,093...107,942,695

G

autocrine motility factor receptor

increases expression

tolcapone results in increased expression of AMFR mRNA

NCBI chr19:11,002,451...11,038,182
Ensembl chr19:10,996,099...11,032,247

G

adipocyte plasma membrane associated protein

affects binding

tolcapone binds to APMAP protein

NCBI chr 3:159,869,451...159,897,727
Ensembl chr 3:139,409,022...139,437,341

G

apolipoprotein A1

affects binding

tolcapone binds to APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

decreases expression
decreases secretion

tolcapone results in decreased expression of APOB mRNA
tolcapone results in decreased secretion of APOB protein alternative form

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C2

decreases expression

tolcapone results in decreased expression of APOC2 mRNA

NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:79,329,428...79,334,476

G

apolipoprotein E

affects binding

tolcapone binds to APOE protein

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein O-like

decreases expression

tolcapone results in decreased expression of APOOL mRNA

NCBI chr X:81,569,960...81,635,906
Ensembl chr X:77,377,781...77,443,900

G

ARF GTPase 4

affects binding

tolcapone binds to ARF4 protein

NCBI chr16:1,903,238...1,920,012
Ensembl chr16:1,896,546...1,913,261

G

ARF like GTPase 1

affects binding

tolcapone binds to ARL1 protein

NCBI chr 7:25,007,401...25,018,572
Ensembl chr 7:23,119,589...23,131,898

G

ATPase family, AAA domain containing 1

affects binding

tolcapone binds to ATAD1 protein

NCBI chr 1:239,957,329...240,023,792
Ensembl chr 1:230,544,047...230,596,548

G

ATPase family, AAA domain containing 3A

affects binding

tolcapone binds to ATAD3A protein

NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:166,350,304...166,370,482

G

activating transcription factor 5

increases expression

tolcapone results in increased expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:95,295,610...95,299,707

G

ATPase Na+/K+ transporting subunit beta 3

affects binding

tolcapone binds to ATP1B3 protein

NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase F1 subunit beta

affects binding

tolcapone binds to ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273

G

ATP synthase F1 subunit gamma

affects binding

Tolcapone binds to ATP5F1C protein

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:68,423,909...68,608,367

G

ATP synthase F1 subunit epsilon

decreases expression

tolcapone results in decreased expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:163,260,476...163,261,450

G

ATP synthase membrane subunit e

decreases expression
affects binding

tolcapone results in decreased expression of ATP5ME mRNA
tolcapone binds to ATP5ME protein

PMID:19783845 PMID:24136188

NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit f

affects binding

tolcapone binds to ATP5MF protein

NCBI chr12:14,535,435...14,542,007
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase membrane subunit G

decreases expression
affects binding

tolcapone results in decreased expression of ATP5MG mRNA
tolcapone binds to ATP5MG protein

PMID:19783845 PMID:24136188

NCBI chr 8:54,122,457...54,130,407
Ensembl chr 8:45,225,686...45,233,559

G

ATP synthase membrane subunit K

decreases expression

Tolcapone results in decreased expression of ATP5MK mRNA

NCBI chr 1:255,915,255...255,922,185
Ensembl chr 1:245,973,914...245,980,761
Ensembl chr10:245,973,914...245,980,761

G

ATP synthase peripheral stalk subunit F6

decreases expression

tolcapone results in decreased expression of ATP5PF mRNA

NCBI chr11:37,368,045...37,375,721
Ensembl chr11:23,881,592...23,889,119

G

ATP synthase peripheral stalk subunit OSCP

affects binding

tolcapone binds to ATP5PO protein

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:31,165,217...31,171,592

G

AU RNA binding methylglutaconyl-CoA hydratase

affects binding

tolcapone binds to AUH protein

NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,329,524...12,424,896

G

gamma-butyrobetaine hydroxylase 1

decreases expression

tolcapone results in decreased expression of BBOX1 mRNA

NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:96,822,655...96,871,458

G

basal cell adhesion molecule (Lutheran blood group)

affects binding

tolcapone binds to BCAM protein

NCBI chr 1:88,542,971...88,557,358
Ensembl chr 1:79,415,017...79,429,403

G

B-cell receptor-associated protein 29

decreases expression

tolcapone results in decreased expression of BCAP29 mRNA

NCBI chr 6:53,910,209...53,950,206
Ensembl chr 6:48,182,706...48,222,720

G

BCAS2, pre-mRNA processing factor

decreases expression

tolcapone results in decreased expression of BCAS2 mRNA

NCBI chr 2:193,381,000...193,388,881
Ensembl chr 2:190,692,461...190,700,389

G

bridge-like lipid transfer protein family member 1

increases expression

Tolcapone results in increased expression of BLTP1 mRNA

NCBI chr 2:121,636,181...121,852,802
Ensembl chr 2:119,708,209...119,924,695

G

BMP-binding endothelial regulator

affects binding

tolcapone binds to BMPER protein

NCBI chr 8:30,008,049...30,253,201
Ensembl chr 8:21,732,225...21,977,256

G

BMS1 ribosome biogenesis factor

affects binding

tolcapone binds to BMS1 protein

NCBI chr 4:153,230,471...153,267,437
Ensembl chr 4:151,558,163...151,595,127

G

bisphosphoglycerate mutase

decreases expression

tolcapone results in decreased expression of BPGM mRNA

NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:63,140,018...63,168,581

G

basic transcription factor 3-like 4

decreases expression

tolcapone results in decreased expression of BTF3L4 mRNA

NCBI chr 5:123,567,902...123,587,527
Ensembl chr 5:123,567,907...123,586,866

G

C1D nuclear receptor corepressor

decreases expression

tolcapone results in decreased expression of C1D mRNA

NCBI chr14:95,862,550...95,874,796
Ensembl chr14:91,660,989...91,672,852

G

C1GALT1-specific chaperone 1

decreases expression

tolcapone results in decreased expression of C1GALT1C1 mRNA

NCBI chr X:122,243,736...122,248,217
Ensembl chr X:117,375,525...117,382,787

G

complement C4B

increases expression

tolcapone results in increased expression of C4B mRNA

NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681

G

complement C5

increases expression

tolcapone results in increased expression of C5 mRNA

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994

G

complement C8 alpha chain

increases expression

tolcapone results in increased expression of C8A mRNA

NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754

G

similar to human chromosome 11 open reading frame 71

decreases expression

Tolcapone results in decreased expression of C8H11ORF71 mRNA

NCBI chr 8:48,838,556...48,838,970
Ensembl chr 8:48,838,100...48,842,270

G

similar to human chromosome 15 open reading frame 61

decreases expression

Tolcapone results in decreased expression of C8H15ORF61 mRNA

NCBI chr 8:72,763,513...72,768,248
Ensembl chr 8:63,868,125...63,872,751

G

carbonyl reductase 4

decreases expression

tolcapone results in decreased expression of CBR4 mRNA

NCBI chr16:33,625,734...33,695,067
Ensembl chr16:28,617,224...28,645,712

G

cyclin L2

increases expression

tolcapone results in increased expression of CCNL2 mRNA

NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:166,417,508...166,436,882

G

chaperonin containing TCP1 subunit 7

affects binding

tolcapone binds to CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580

G

CD36 molecule

increases expression

tolcapone results in increased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

complement factor B

increases expression

tolcapone results in increased expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505

G

coiled-coil-helix-coiled-coil-helix domain containing 1

decreases expression

tolcapone results in decreased expression of CHCHD1 mRNA

NCBI chr15:3,641,973...3,643,155
Ensembl chr15:3,592,727...3,593,901

G

coiled-coil-helix-coiled-coil-helix domain containing 7

decreases expression

tolcapone results in decreased expression of CHCHD7 mRNA

NCBI chr 5:21,754,719...21,759,274
Ensembl chr 5:16,957,188...16,961,184

G

chromatin accessibility complex subunit 1

decreases expression

tolcapone results in decreased expression of CHRAC1 mRNA

NCBI chr 7:106,901,841...106,905,441
Ensembl chr 7:105,013,015...105,017,136

G

churchill domain containing 1

decreases expression

tolcapone results in decreased expression of CHURC1 mRNA

NCBI chr 6:101,203,778...101,218,364
Ensembl chr 6:95,470,683...95,619,586

G

cytosolic iron-sulfur assembly component 2A

decreases expression

tolcapone results in decreased expression of CIAO2A mRNA

NCBI chr 8:75,565,620...75,577,542
Ensembl chr 8:66,670,483...66,682,455

G

cell death-inducing DFFA-like effector a

increases expression

tolcapone results in increased expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:60,894,874...60,920,481

G

CDGSH iron sulfur domain 1

affects binding

tolcapone binds to CISD1 protein

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,255,151...17,284,924

G

C-type lectin domain family 4, member A3

decreases expression

Tolcapone results in decreased expression of CLEC4A3 mRNA

NCBI chr 4:157,885,899...157,896,728
Ensembl chr 4:156,214,718...156,224,817

G

clathrin heavy chain

affects binding

tolcapone binds to CLTC protein

NCBI chr10:72,014,984...72,073,308
Ensembl chr10:71,517,663...71,573,737

G

cornichon family member 4

decreases expression

tolcapone results in decreased expression of CNIH4 mRNA

NCBI chr13:95,442,054...95,458,163
Ensembl chr13:92,910,315...92,927,853

G

COMM domain containing 6

decreases expression

tolcapone results in decreased expression of COMMD6 mRNA

NCBI chr15:84,882,069...84,889,124
Ensembl chr15:78,467,804...78,474,382

G

catechol-O-methyltransferase

decreases activity
multiple interactions
increases methylation
affects binding

tolcapone results in decreased activity of COMT protein
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
COMT protein results in increased methylation of tolcapone
tolcapone binds to COMT protein

PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 More...

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

COPI coat complex subunit gamma 1

affects binding

tolcapone binds to COPG1 protein

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:120,366,542...120,415,616

G

COPI coat complex subunit gamma 2

decreases expression

tolcapone results in decreased expression of COPG2 mRNA

NCBI chr 4:60,333,455...60,468,953
Ensembl chr 4:59,366,086...59,501,618

G

coenzyme Q10A

decreases expression

tolcapone results in decreased expression of COQ10A mRNA

NCBI chr 7:1,376,591...1,387,694
Ensembl chr 7:792,089...800,161

G

coenzyme Q3 methyltransferase

decreases expression

tolcapone results in decreased expression of COQ3 mRNA

NCBI chr 5:40,226,313...40,257,383
Ensembl chr 5:35,429,574...35,460,607

G

cytochrome c oxidase subunit 6C

affects binding
decreases expression

tolcapone binds to COX6C protein
tolcapone results in decreased expression of COX6C mRNA

PMID:19783845 PMID:24136188

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:67,111,024...67,141,963

G

cytochrome c oxidase subunit 7A2

decreases expression

tolcapone results in decreased expression of COX7A2 mRNA

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 7B

decreases expression

tolcapone results in decreased expression of COX7B mRNA

NCBI chr X:75,149,036...75,155,285
Ensembl chr X:71,083,456...71,089,732

G

ceruloplasmin

increases expression

tolcapone results in increased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075

G

cAMP responsive element modulator

decreases expression

tolcapone results in decreased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989

G

cysteine-rich protein 2

increases expression

tolcapone results in increased expression of CRIP2 mRNA

NCBI chr 6:138,042,175...138,047,121
Ensembl chr 6:132,221,082...132,226,065

G

chromosome segregation 1 like

affects binding

tolcapone binds to CSE1L protein

NCBI chr 3:176,060,183...176,097,909
Ensembl chr 3:155,641,166...155,678,865

G

cystatin B

decreases expression

tolcapone results in decreased expression of CSTB mRNA

NCBI chr20:10,245,157...10,247,199
Ensembl chr20:10,245,462...10,247,526

G

cytochrome c-1

affects binding

tolcapone binds to CYC1 protein

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Tolcapone results in decreased activity of CYP1A1 protein

PMID:18493746 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
tolcapone results in increased expression of CYP1A2 mRNA

PMID:18493746 PMID:24136188

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Tolcapone results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance

CYP3A4 protein results in increased susceptibility to Tolcapone

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

increases expression

tolcapone results in increased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

death-associated protein

increases expression

tolcapone results in increased expression of DAP mRNA

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:82,199,280...82,251,752

G

dCMP deaminase

affects binding

tolcapone binds to DCTD protein

NCBI chr16:50,799,699...50,831,398
Ensembl chr16:44,055,128...44,098,446

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

affects binding

tolcapone binds to DDOST protein

NCBI chr 5:155,805,612...155,812,728
Ensembl chr 5:150,522,242...150,529,413

G

DEAD-box helicase 18

affects binding

tolcapone binds to DDX18 protein

NCBI chr13:35,282,391...35,296,038
Ensembl chr13:32,729,700...32,743,161

G

24-dehydrocholesterol reductase

affects binding
increases expression

tolcapone binds to DHCR24 protein
tolcapone results in increased expression of DHCR24 mRNA

PMID:19783845 PMID:24136188

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

affects binding

tolcapone binds to DHCR7 protein

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:199,015,081...199,031,055

G

distal membrane arm assembly component 1

decreases expression

tolcapone results in decreased expression of DMAC1 mRNA

NCBI chr 5:94,288,900...94,290,053
Ensembl chr 5:89,242,661...89,243,757

G

DnaJ heat shock protein family (Hsp40) member C15

decreases expression

tolcapone results in decreased expression of DNAJC15 mRNA

NCBI chr15:59,594,314...59,658,862
Ensembl chr15:53,184,855...53,249,675

G

dedicator of cytokinesis 11

decreases expression

tolcapone results in decreased expression of DOCK11 mRNA

NCBI chr X:119,997,523...120,180,643
Ensembl chr X:115,131,909...115,314,854

G

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

decreases expression

tolcapone results in decreased expression of DPM3 mRNA

NCBI chr 2:176,974,290...176,974,805
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668

G

dpy-30 histone methyltransferase complex regulatory subunit

decreases expression

tolcapone results in decreased expression of DPY30 mRNA

NCBI chr 6:26,872,812...26,893,580
Ensembl chr 6:21,120,947...21,141,432

G

deoxythymidylate kinase

decreases expression

tolcapone results in decreased expression of DTYMK mRNA

NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:94,315,552...94,324,870

G

dynein light chain LC8-type 1

decreases expression

tolcapone results in decreased expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:41,312,367...41,314,741

G

dynein light chain Tctex-type 3

decreases expression

tolcapone results in decreased expression of DYNLT3 mRNA

NCBI chr X:16,000,425...16,009,632
Ensembl chr X:13,327,892...13,337,139

G

EBP, cholestenol delta-isomerase

increases expression

tolcapone results in increased expression of EBP mRNA

NCBI chr X:16,971,372...16,977,782
Ensembl chr X:14,299,448...14,305,826

G

enoyl-CoA hydratase, short chain 1

affects binding

tolcapone binds to ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:194,895,036...194,903,884

G

elongin C

decreases expression

tolcapone results in decreased expression of ELOC mRNA

NCBI chr 5:7,444,769...7,461,187
Ensembl chr 5:2,661,724...2,677,890
Ensembl chr20:2,661,724...2,677,890

G

epiregulin

decreases expression

Tolcapone results in decreased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,027,287...17,041,062

G

coagulation factor V

increases expression

tolcapone results in increased expression of F5 mRNA

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:76,513,255...76,582,317

G

family with sequence similarity 162, member A

affects binding

tolcapone binds to FAM162A protein

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:64,680,323...64,711,239

G

fibrillarin-like 1

affects binding

tolcapone binds to FBLL1 protein

NCBI chr10:20,762,716...20,764,359
Ensembl chr10:20,258,656...20,260,299

G

Fcf1 rRNA-processing protein

decreases expression

tolcapone results in decreased expression of FCF1 mRNA

NCBI chr 6:110,348,854...110,360,715
Ensembl chr 6:104,617,770...104,629,643

G

fibrinogen alpha chain

affects binding

tolcapone binds to FGA protein

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528

G

formation of mitochondrial complex V assembly factor 1

decreases expression

tolcapone results in decreased expression of FMC1 mRNA

NCBI chr 4:68,241,009...68,249,045
Ensembl chr 4:67,274,104...67,282,140

G

glutaryl-CoA dehydrogenase

affects binding

tolcapone binds to GCDH protein

NCBI chr19:40,168,038...40,174,536
Ensembl chr19:23,263,264...23,269,681

G

golgi glycoprotein 1

affects binding

tolcapone binds to GLG1 protein

NCBI chr19:56,034,248...56,133,538
Ensembl chr19:39,124,641...39,224,178

G

glia maturation factor, gamma

decreases expression

tolcapone results in decreased expression of GMFG mRNA

NCBI chr 1:92,856,154...92,866,722
Ensembl chr 1:83,728,776...83,739,183

G

G protein subunit gamma 10

decreases expression

tolcapone results in decreased expression of GNG10 mRNA

NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:73,856,164...73,863,012
Ensembl chr 5:73,856,164...73,863,012

G

G protein subunit gamma 5

decreases expression

tolcapone results in decreased expression of GNG5 mRNA

NCBI chr 2:238,054,954...238,063,451
Ensembl chr 1:77,292,043...77,292,513
Ensembl chr11:77,292,043...77,292,513

G

glypican 3

affects binding

tolcapone binds to GPC3 protein

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:131,868,990...132,236,798

G

general transcription factor IIH subunit 5

decreases expression

tolcapone results in decreased expression of GTF2H5 mRNA

NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:46,656,859...46,664,939

G

H2A.Z variant histone 2

affects binding

Tolcapone binds to H2AZ2 protein

NCBI chr14:85,507,228...85,526,166
Ensembl chr14:81,293,299...81,312,144
Ensembl chr 4:81,293,299...81,312,144
Ensembl chr16:81,293,299...81,312,144

G

hemoglobin subunit beta

affects binding

tolcapone binds to HBB protein

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012

G

HIG1 hypoxia inducible domain family, member 1A

decreases expression

tolcapone results in decreased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:121,514,156...121,523,443

G

histidine triad nucleotide binding protein 3

decreases expression

tolcapone results in decreased expression of HINT3 mRNA

NCBI chr 1:28,854,860...28,864,723
Ensembl chr 1:27,035,905...27,047,721

G

histone cluster 1 H4 family member B

decreases expression

Tolcapone results in decreased expression of HIST1H4B mRNA

NCBI chr17:47,176,246...47,180,690
Ensembl chr17:42,480,313...42,485,370

G

heterogeneous nuclear ribonucleoprotein H1

affects binding

tolcapone binds to HNRNPH1 protein

NCBI chr10:35,187,412...35,203,909
Ensembl chr10:34,693,555...34,702,846

G

hydroxysteroid (17-beta) dehydrogenase 11

affects binding

tolcapone binds to HSD17B11 protein

NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,711,964...5,743,161

G

hydroxysteroid (17-beta) dehydrogenase 12

affects binding

tolcapone binds to HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 13

affects binding

tolcapone binds to HSD17B13 protein

NCBI chr14:6,056,708...6,071,463
Ensembl chr14:5,752,132...5,768,166

G

hydroxysteroid (17-beta) dehydrogenase 4

affects binding

tolcapone binds to HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid dehydrogenase like 2

increases expression

tolcapone results in increased expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:74,443,872...74,479,839

G

intraflagellar transport associated protein

decreases expression

Tolcapone results in decreased expression of IFTAP mRNA

NCBI chr 3:108,242,105...108,361,607
Ensembl chr 3:87,817,408...87,906,547

G

insulin-like growth factor binding protein 1

increases expression

tolcapone results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482

G

interleukin 24

decreases expression

Tolcapone results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487

G

importin 7

affects binding

tolcapone binds to IPO7 protein

NCBI chr 1:173,497,472...173,537,707
Ensembl chr 1:164,062,702...164,102,938

G

integral membrane protein 2A

affects binding

tolcapone binds to ITM2A protein

NCBI chr X:76,559,183...76,565,144
Ensembl chr X:72,486,381...72,492,363

G

jagunal homolog 1

affects binding

tolcapone binds to JAGN1 protein

NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:146,591,510...146,596,288

G

potassium voltage-gated channel subfamily H member 2

decreases activity

tolcapone results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

alpha-ketoglutarate dehydrogenase subunit 4

decreases expression

Tolcapone results in decreased expression of KGD4 mRNA

NCBI chr 2:33,604,611...33,614,988
Ensembl chr 2:31,870,551...31,880,730

G

kininogen 1

increases expression

Tolcapone results in increased expression of KNG1 mRNA

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555

G

L antigen family, member 3

decreases expression

tolcapone results in decreased expression of LAGE3 mRNA

NCBI chr X:157,289,497...157,290,920
Ensembl chr X:152,138,218...152,139,632

G

lipopolysaccharide binding protein

increases expression

tolcapone results in increased expression of LBP mRNA

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586

G

leucine rich repeat containing 59

affects binding

tolcapone binds to LRRC59 protein

NCBI chr10:80,069,162...80,083,820
Ensembl chr10:79,572,317...79,602,533

G

LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

tolcapone results in decreased expression of LSM3 mRNA

NCBI chr 4:125,578,185...125,584,429
Ensembl chr 4:124,021,023...124,027,269

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

tolcapone results in decreased expression of LSM5 mRNA

NCBI chr 4:87,281,260...87,284,476
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

tolcapone results in decreased expression of LSM7 mRNA

NCBI chr 7:9,507,373...9,509,787
Ensembl chr 7:8,856,489...8,859,119

G

mago homolog, exon junction complex subunit

decreases expression

tolcapone results in decreased expression of MAGOH mRNA

NCBI chr 5:127,868,044...127,875,423
Ensembl chr 5:122,639,308...122,646,617

G

MBL associated serine protease 1

increases expression

tolcapone results in increased expression of MASP1 mRNA

NCBI chr11:90,839,081...90,909,922
Ensembl chr11:77,334,859...77,402,974

G

matrin 3

decreases expression

tolcapone results in decreased expression of MATR3 mRNA

NCBI chr18:27,428,190...27,474,421
Ensembl chr18:27,163,714...27,193,166

G

methylmalonyl CoA epimerase

decreases expression

tolcapone results in decreased expression of MCEE mRNA

NCBI chr 1:127,376,311...127,399,551
Ensembl chr 1:117,964,576...117,988,484

G

MCTS1, re-initiation and release factor

decreases expression

tolcapone results in decreased expression of MCTS1 mRNA

NCBI chr X:122,215,602...122,228,101
Ensembl chr X:117,350,889...117,362,504

G

mediator complex subunit 21

decreases expression

tolcapone results in decreased expression of MED21 mRNA

NCBI chr 4:181,291,191...181,314,504
Ensembl chr 4:179,560,579...179,567,548

G

mediator complex subunit 28

decreases expression

tolcapone results in decreased expression of MED28 mRNA

NCBI chr14:69,807,319...69,816,115
Ensembl chr14:65,594,647...65,603,583

G

mediator complex subunit 31

decreases expression

tolcapone results in decreased expression of MED31 mRNA

NCBI chr10:57,335,507...57,338,889
Ensembl chr10:56,836,944...56,840,326

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Tolcapone results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

methyltransferase 5, N6-adenosine

decreases expression

tolcapone results in decreased expression of METTL5 mRNA

NCBI chr 3:75,033,605...75,046,359
Ensembl chr 3:54,625,793...54,638,039

G

major facilitator superfamily domain containing 5

decreases expression

tolcapone results in decreased expression of MFSD5 mRNA

NCBI chr 7:135,287,683...135,289,964
Ensembl chr 7:133,402,537...133,411,396

G

microsomal glutathione S-transferase 1

affects binding

tolcapone binds to MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:171,029,630...171,044,892

G

MIA SH3 domain ER export factor 3

decreases expression

tolcapone results in decreased expression of MIA3 mRNA

NCBI chr13:97,502,040...97,547,155
Ensembl chr13:94,970,424...95,011,972

G

MKKS centrosomal shuttling protein

decreases expression

tolcapone results in decreased expression of MKKS mRNA

NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:124,201,877...124,220,162

G

makorin ring finger protein 1

decreases expression

tolcapone results in decreased expression of MKRN1 mRNA

NCBI chr 4:69,142,710...69,170,211
Ensembl chr 4:68,175,909...68,197,165
Ensembl chr 9:68,175,909...68,197,165

G

metabolism of cobalamin associated D

decreases expression

tolcapone results in decreased expression of MMADHC mRNA

NCBI chr 3:55,117,832...55,135,735
Ensembl chr 3:34,708,649...34,726,771

G

mitochondrial ribosomal protein L1

decreases expression

tolcapone results in decreased expression of MRPL1 mRNA

NCBI chr14:13,604,498...13,663,633
Ensembl chr14:13,300,522...13,359,721

G

mitochondrial ribosomal protein L13

decreases expression

tolcapone results in decreased expression of MRPL13 mRNA

NCBI chr 7:88,841,265...88,862,821
Ensembl chr 7:86,951,541...86,973,577

G

mitochondrial ribosomal protein L14

decreases expression

tolcapone results in decreased expression of MRPL14 mRNA

NCBI chr 9:22,800,286...22,812,711
Ensembl chr 9:15,302,427...15,315,267

G

mitochondrial ribosomal protein L18

decreases expression

tolcapone results in decreased expression of MRPL18 mRNA

NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:47,836,561...47,841,987

G

mitochondrial ribosomal protein L20

decreases expression

tolcapone results in decreased expression of MRPL20 mRNA

NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:166,408,962...166,413,492

G

mitochondrial ribosomal protein L22

decreases expression

tolcapone results in decreased expression of MRPL22 mRNA

NCBI chr10:42,843,165...42,856,243
Ensembl chr10:42,342,776...42,355,779

G

mitochondrial ribosomal protein L23

decreases expression

tolcapone results in decreased expression of MRPL23 mRNA

NCBI chr 1:207,116,930...207,124,702
Ensembl chr 1:197,687,347...197,695,222

G

mitochondrial ribosomal protein L30

decreases expression

tolcapone results in decreased expression of MRPL30 mRNA

NCBI chr 9:47,621,226...47,631,986
Ensembl chr 9:40,125,430...40,137,257

G

mitochondrial ribosomal protein L32

decreases expression

tolcapone results in decreased expression of MRPL32 mRNA

NCBI chr17:55,260,651...55,263,517
Ensembl chr17:50,565,055...50,568,010

G

mitochondrial ribosomal protein L36

decreases expression

tolcapone results in decreased expression of MRPL36 mRNA

NCBI chr 1:31,794,025...31,797,446
Ensembl chr 1:29,965,317...29,968,807

G

mitochondrial ribosomal protein L40

decreases expression

tolcapone results in decreased expression of MRPL40 mRNA

NCBI chr11:95,637,751...95,643,587
Ensembl chr11:82,133,398...82,139,233

G

mitochondrial ribosomal protein L53

decreases expression

tolcapone results in decreased expression of MRPL53 mRNA

NCBI chr 4:117,173,043...117,173,933

G

mitochondrial ribosomal protein S14

decreases expression

tolcapone results in decreased expression of MRPS14 mRNA

NCBI chr13:74,962,597...74,968,344
Ensembl chr13:72,408,558...72,434,915

G

mitochondrial ribosomal protein S18C

decreases expression

tolcapone results in decreased expression of MRPS18C mRNA

NCBI chr14:9,116,688...9,122,943
Ensembl chr14:8,791,330...8,818,516

G

mitochondrial ribosomal protein S24

decreases expression

tolcapone results in decreased expression of MRPS24 mRNA

NCBI chr14:84,798,649...84,802,777
Ensembl chr14:80,584,673...80,588,871

G

mitochondrial ribosomal protein S33

decreases expression

tolcapone results in decreased expression of MRPS33 mRNA

NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:68,596,729...68,605,428

G

methylthioadenosine phosphorylase

affects binding

tolcapone binds to MTAP protein

NCBI chr 5:108,990,270...109,036,494
Ensembl chr 5:103,873,020...103,939,406

G

microsomal triglyceride transfer protein

increases expression

tolcapone results in increased expression of MTTP protein

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:226,613,090...226,654,239

G

mevalonate kinase

increases expression

tolcapone results in increased expression of MVK mRNA

NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882

G

N(alpha)-acetyltransferase 20, NatB catalytic subunit

decreases expression

tolcapone results in decreased expression of NAA20 mRNA

NCBI chr 3:153,775,351...153,790,129
Ensembl chr 3:133,322,064...133,337,009

G

N-acetyltransferase 10

affects binding

tolcapone binds to NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:90,111,645...90,149,927

G

NADH:ubiquinone oxidoreductase subunit A1

decreases expression

tolcapone results in decreased expression of NDUFA1 mRNA

NCBI chr X:121,289,904...121,293,555
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit A2

decreases expression

tolcapone results in decreased expression of NDUFA2 mRNA

NCBI chr18:28,629,795...28,631,884
Ensembl chr18:28,355,774...28,358,076

G

NADH:ubiquinone oxidoreductase subunit A6

decreases expression

tolcapone results in decreased expression of NDUFA6 mRNA

NCBI chr 7:115,746,460...115,750,317
Ensembl chr 7:113,866,382...113,870,239

G

NADH:ubiquinone oxidoreductase subunit A7

decreases expression

tolcapone results in decreased expression of NDUFA7 mRNA

NCBI chr 7:15,311,446...15,324,226
Ensembl chr 7:14,609,146...14,631,976

G

NADH:ubiquinone oxidoreductase subunit A9

affects binding

tolcapone binds to NDUFA9 protein

NCBI chr 4:161,345,398...161,374,188
Ensembl chr 4:159,659,242...159,688,018

G

NADH:ubiquinone oxidoreductase subunit B6

decreases expression

tolcapone results in decreased expression of NDUFB6 mRNA

NCBI chr 5:60,196,585...60,206,152
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase subunit C2

decreases expression

tolcapone results in decreased expression of NDUFC2 mRNA

NCBI chr 1:161,122,370...161,129,413
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase subunit S4

decreases expression

tolcapone results in decreased expression of NDUFS4 mRNA

NCBI chr 2:47,684,420...47,794,914
Ensembl chr 2:45,951,313...46,061,846

G

NADH:ubiquinone oxidoreductase subunit S5

decreases expression

tolcapone results in decreased expression of NDUFS5 mRNA

NCBI chr 5:141,258,828...141,264,552
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

NFE2 like bZIP transcription factor 2

decreases expression

tolcapone results in decreased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nipsnap homolog 1

affects binding

tolcapone binds to NIPSNAP1 protein

NCBI chr14:83,957,714...83,981,579
Ensembl chr14:79,734,209...79,758,098

G

nipsnap homolog 2

affects binding

tolcapone binds to NIPSNAP2 protein

NCBI chr12:32,542,171...32,580,345
Ensembl chr12:26,911,723...26,944,166

G

NME/NM23 nucleoside diphosphate kinase 3

decreases expression

tolcapone results in decreased expression of NME3 mRNA

NCBI chr10:14,421,922...14,422,878
Ensembl chr10:13,917,403...13,918,359

G

NOP56 ribonucleoprotein

affects binding

tolcapone binds to NOP56 protein

NCBI chr 3:137,926,187...137,934,971
Ensembl chr 3:117,477,053...117,481,841

G

nephrocystin 1

decreases expression

tolcapone results in decreased expression of NPHP1 mRNA

NCBI chr 3:135,413,927...135,469,505
Ensembl chr 3:114,960,650...115,016,234

G

NPL4 homolog, ubiquitin recognition factor

increases expression

tolcapone results in increased expression of NPLOC4 mRNA

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:105,654,812...105,709,913

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

tolcapone results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

nuclear protein 2, transcriptional regulator

decreases expression

tolcapone results in decreased expression of NUPR2 mRNA

NCBI chr12:32,436,233...32,439,391
Ensembl chr12:26,799,800...26,803,304

G

prolyl 4-hydroxylase subunit alpha 1

affects binding

tolcapone binds to P4HA1 protein

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,302,141...27,352,786

G

pyruvate carboxylase

affects binding

tolcapone binds to PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380

G

proliferating cell nuclear antigen

decreases expression

tolcapone results in decreased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

phosphate cytidylyltransferase 1A, choline

affects binding

tolcapone binds to PCYT1A protein

NCBI chr11:81,818,914...81,862,623
Ensembl chr11:68,313,882...68,357,357

G

PDZ domain containing 11

decreases expression

tolcapone results in decreased expression of PDZD11 mRNA

NCBI chr X:69,758,765...69,761,811
Ensembl chr X:65,704,067...65,721,642

G

prefoldin subunit 1

decreases expression

tolcapone results in decreased expression of PFDN1 mRNA

NCBI chr18:28,288,210...28,341,198
Ensembl chr18:28,014,145...28,067,064

G

prefoldin subunit 5

decreases expression

tolcapone results in decreased expression of PFDN5 mRNA

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:133,451,453...133,456,516

G

phosphoglucomutase 1

increases expression

tolcapone results in increased expression of PGM1 mRNA

NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:114,595,293...114,654,728

G

progesterone receptor

multiple interactions

tolcapone binds to and results in decreased activity of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol glycan anchor biosynthesis, class P

decreases expression

tolcapone results in decreased expression of PIGP mRNA

NCBI chr11:47,152,601...47,158,766
Ensembl chr11:33,682,948...33,689,321

G

phosphatidylinositol glycan anchor biosynthesis, class S

affects binding

tolcapone binds to PIGS protein

NCBI chr10:63,720,568...63,735,255
Ensembl chr10:63,222,572...63,237,187

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 4

decreases expression

tolcapone results in decreased expression of PIN4 mRNA

NCBI chr X:71,272,034...71,278,676
Ensembl chr X:67,232,081...67,238,702

G

perilipin 2

affects binding

tolcapone binds to PLIN2 protein

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319

G

perilipin 3

affects binding

tolcapone binds to PLIN3 protein

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,102,366...1,123,147

G

patatin-like phospholipase domain containing 2

increases expression

tolcapone results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805

G

RNA polymerase I subunit H

decreases expression

Tolcapone results in decreased expression of POLR1H mRNA

NCBI chr20:1,600,170...1,604,088
Ensembl chr20:1,594,936...1,598,854

G

RNA polymerase II subunit G

decreases expression

tolcapone results in decreased expression of POLR2G mRNA

NCBI chr 1:215,118,278...215,125,389
Ensembl chr 1:205,689,160...205,692,686

G

pre-mRNA processing factor 8

affects binding

tolcapone binds to PRPF8 protein

NCBI chr10:60,829,778...60,852,887
Ensembl chr10:60,331,494...60,354,606

G

peroxiredoxin like 2A

affects binding

tolcapone binds to PRXL2A protein

NCBI chr16:16,900,697...16,920,521
Ensembl chr16:16,866,603...16,886,433

G

proteasome 26S subunit, ATPase 5

affects binding

tolcapone binds to PSMC5 protein

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,187,743...91,213,135

G

proteasome activator subunit 2

affects binding

tolcapone binds to PSME2 protein

NCBI chr15:33,048,452...33,053,055
Ensembl chr15:29,078,500...29,082,946

G

prostaglandin-endoperoxide synthase 2

increases expression

Tolcapone results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

peptidyl-tRNA hydrolase 2

affects binding

tolcapone binds to PTRH2 protein

NCBI chr10:72,002,450...72,012,606
Ensembl chr10:71,504,956...71,515,398

G

RNA guanine-7 methyltransferase activating subunit

decreases expression

tolcapone results in decreased expression of RAMAC mRNA

NCBI chr 1:145,117,752...145,123,640
Ensembl chr 1:135,708,535...135,722,151

G

RAN, member RAS oncogene family

affects binding

tolcapone binds to RAN protein

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:27,674,050...27,678,276

G

RAP1A, member of RAS oncogene family

decreases expression

tolcapone results in decreased expression of RAP1A mRNA

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501

G

ribosomal biogenesis factor

decreases expression

Tolcapone results in decreased expression of RBIS mRNA

NCBI chr 2:88,702,599...88,718,587
Ensembl chr 2:86,991,315...87,041,339

G

RNA binding motif protein 8A

decreases expression

tolcapone results in decreased expression of RBM8A mRNA

NCBI chr 2:186,854,018...186,856,802
Ensembl chr 2:184,165,193...184,167,959

G

retinol binding protein 1

decreases expression

tolcapone results in decreased expression of RBP1 mRNA

NCBI chr 8:107,904,589...107,926,109
Ensembl chr 8:99,025,206...99,046,743

G

receptor accessory protein 6

affects binding

tolcapone binds to REEP6 protein

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:9,373,927...9,380,597

G

similar to RIKEN cDNA 1110059G10

decreases expression

tolcapone results in decreased expression of RGD1311745 mRNA

NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:122,598,401...122,609,168

G

ring finger protein 7

decreases expression

tolcapone results in decreased expression of RNF7 mRNA

NCBI chr 8:105,918,395...105,927,643
Ensembl chr 8:97,038,840...97,047,824

G

renalase, FAD-dependent amine oxidase

decreases expression

tolcapone results in decreased expression of RNLS mRNA

NCBI chr 1:240,450,702...240,723,472
Ensembl chr 1:231,037,486...231,309,823

G

reactive oxygen species modulator 1

decreases expression

tolcapone results in decreased expression of ROMO1 mRNA

NCBI chr 3:165,119,794...165,121,394
Ensembl chr 3:144,659,826...144,661,310

G

replication protein A3

decreases expression

tolcapone results in decreased expression of RPA3 mRNA

NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:36,304,651...36,307,709

G

ribosomal protein L10A

affects binding

tolcapone binds to RPL10A protein

NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L15

affects binding

tolcapone binds to RPL15 protein

NCBI chr15:9,934,663...9,937,946
Ensembl chr15:7,503,883...7,507,165
Ensembl chr12:7,503,883...7,507,165

G

ribosomal protein L18A

affects binding

tolcapone binds to RPL18A protein

NCBI chr16:18,576,467...18,578,653
Ensembl chr16:18,542,566...18,545,546
Ensembl chr 1:18,542,566...18,545,546

G

ribosomal protein L22

affects binding

tolcapone binds to RPL22 protein

NCBI chr 5:168,114,432...168,126,114
Ensembl chr 5:162,833,740...162,843,368
Ensembl chr 7:162,833,740...162,843,368
Ensembl chr 4:162,833,740...162,843,368

G

ribosomal protein L22 like 1

decreases expression

tolcapone results in decreased expression of RPL22L1 mRNA

NCBI chr 2:113,683,196...113,685,132
Ensembl chr 2:111,754,687...111,756,625

G

ribosomal protein L23

affects binding

tolcapone binds to RPL23 protein

NCBI chr10:83,268,223...83,272,184
Ensembl chr10:82,771,538...82,775,870

G

ribosomal protein L35A

decreases expression

tolcapone results in decreased expression of RPL35A mRNA

NCBI chr11:81,231,114...81,235,094
Ensembl chr11:67,726,032...67,729,942
Ensembl chr 5:67,726,032...67,729,942
Ensembl chr 6:67,726,032...67,729,942
Ensembl chr 7:67,726,032...67,729,942
Ensembl chr12:67,726,032...67,729,942

G

ribosomal protein L36A

decreases expression

tolcapone results in decreased expression of RPL36A mRNA

NCBI chr X:102,058,573...102,062,162
Ensembl chr X:97,766,179...97,768,892
Ensembl chr20:97,766,179...97,768,892

G

ribosomal protein L41

decreases expression

tolcapone results in decreased expression of RPL41 mRNA

NCBI chr 7:1,562,417...1,563,497

G

ribosomal protein L7A

affects binding

tolcapone binds to RPL7A protein

NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:10,239,001...10,241,716
Ensembl chr18:10,239,001...10,241,716

G

ribosomal protein L7-like 1

affects binding

tolcapone binds to RPL7L1 protein

NCBI chr 9:21,695,718...21,703,736
Ensembl chr 9:14,198,092...14,206,110

G

ribosomal protein L9

decreases expression

tolcapone results in decreased expression of RPL9 mRNA

NCBI chr14:43,247,536...43,250,784
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136
Ensembl chr 1:42,893,942...42,897,136

G

ribonuclease P/MRP subunit p21

decreases expression

tolcapone results in decreased expression of RPP21 mRNA

NCBI chr20:1,986,225...2,025,308
Ensembl chr20:2,018,147...2,020,106

G

ribosomal protein S11

affects binding

tolcapone binds to RPS11 protein

NCBI chr 1:104,742,153...104,744,261
Ensembl chr 1:95,605,692...95,607,874

G

ribosomal protein S14

affects binding

tolcapone binds to RPS14 protein

NCBI chr18:56,492,010...56,503,092
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S15a

decreases expression

tolcapone results in decreased expression of RPS15A mRNA

NCBI chr 1:181,854,396...181,861,330
Ensembl chr 1:172,419,761...172,426,995

G

ribosomal protein S20

affects binding

tolcapone binds to RPS20 protein

NCBI chr 5:21,616,687...21,618,068
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
Ensembl chr 5:16,819,304...16,820,475

G

ribosomal protein S21, pseudogene 1

decreases expression

tolcapone results in decreased expression of RPS21 mRNA

NCBI chr 5:158,670,141...158,670,484
Ensembl chr 5:153,387,176...153,387,427

G

ribosomal protein S24

decreases expression

tolcapone results in decreased expression of RPS24 mRNA

NCBI chr16:95,429...101,146
Ensembl chr16:89,604...94,279

G

ribosomal protein s25

decreases expression

tolcapone results in decreased expression of RPS25 mRNA

NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271

G

ribosomal protein S27

decreases expression

tolcapone results in decreased expression of RPS27 mRNA

NCBI chr 2:177,963,499...177,964,708
Ensembl chr 2:175,665,853...175,666,964
Ensembl chr12:175,665,853...175,666,964

G

ribosomal protein S27a

affects binding

tolcapone binds to RPS27A protein

NCBI chr14:107,486,664...107,488,941
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

S100 calcium binding protein A10

decreases expression

tolcapone results in decreased expression of S100A10 mRNA

NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:179,220,887...179,229,661

G

sterol-C5-desaturase

increases expression

tolcapone results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-CoA desaturase

affects binding
decreases expression

tolcapone binds to SCD protein
tolcapone results in decreased expression of SCD1 mRNA

PMID:19783845 PMID:24136188

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

succinate dehydrogenase complex flavoprotein subunit A

affects binding

tolcapone binds to SDHA protein

NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:28,940,164...28,961,535

G

succinate dehydrogenase complex iron sulfur subunit B

affects binding

tolcapone binds to SDHB protein

NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293

G

SEC11 homolog C, signal peptidase complex subunit

affects binding

tolcapone binds to SEC11C protein

NCBI chr18:61,590,905...61,607,247
Ensembl chr18:59,320,884...59,337,364

G

SEC31 homolog A, COPII coat complex component

affects binding

tolcapone binds to SEC31A protein

NCBI chr14:9,518,655...9,573,579
Ensembl chr14:9,214,349...9,269,273

G

Serpine1 mRNA binding protein 1

affects binding

tolcapone binds to SERBP1 protein

NCBI chr 4:97,731,200...97,748,438
Ensembl chr 4:96,401,477...96,421,813

G

splicing factor 3B, subunit 6

affects binding

tolcapone binds to SF3B6 protein

NCBI chr 6:33,545,495...33,554,537
Ensembl chr 6:27,826,029...27,835,156

G

sideroflexin 1

affects binding

tolcapone binds to SFXN1 protein

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,486,271...10,522,529

G

SIK family kinase 3

increases expression

tolcapone results in increased expression of SIK3 mRNA

NCBI chr 8:55,208,969...55,419,138
Ensembl chr 8:46,311,989...46,522,444

G

solute carrier family 1 member 5

affects binding

tolcapone binds to SLC1A5 protein

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 25 member 1

affects binding

tolcapone binds to SLC25A1 protein

NCBI chr11:96,560,054...96,563,071
Ensembl chr11:83,055,748...83,058,781

G

solute carrier family 25 member 13

affects binding

tolcapone binds to SLC25A13 protein

NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:34,179,224...34,361,902

G

solute carrier family 25 member 4

affects binding

tolcapone binds to SLC25A4 protein

NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 25 member 5

affects binding

tolcapone binds to SLC25A5 protein

NCBI chr X:120,897,616...120,900,683
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 25 member 5, pseudogene 11

affects binding

tolcapone binds to SLC25A6 protein

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:68,571,300...68,572,199

G

solute carrier family 39 member 7

affects binding

tolcapone binds to SLC39A7 protein

NCBI chr20:4,824,967...4,828,431
Ensembl chr20:4,822,012...4,826,537

G

solute carrier family 7 member 11

decreases expression

Tolcapone results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

decreases expression

Tolcapone results in decreased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

small integral membrane protein 26

decreases expression

tolcapone results in decreased expression of SMIM26 mRNA

NCBI chr 3:152,443,397...152,445,102
Ensembl chr 3:131,990,291...131,992,132

G

SNAP-associated protein

decreases expression

tolcapone results in decreased expression of SNAPIN mRNA

NCBI chr 2:178,269,157...178,271,746
Ensembl chr 2:175,971,257...175,974,231

G

synuclein alpha

multiple interactions

tolcapone inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262

G

small nuclear ribonucleoprotein U4/U6.U5 subunit 27

decreases expression

Tolcapone results in decreased expression of SNRNP27 mRNA

NCBI chr 4:120,681,054...120,691,343
Ensembl chr 4:119,121,877...119,133,234

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

tolcapone results in decreased expression of SNRPB2 mRNA

NCBI chr 3:150,852,814...150,862,364
Ensembl chr 3:130,399,248...130,408,812

G

small nuclear ribonucleoprotein D3 polypeptide

decreases expression

tolcapone results in decreased expression of SNRPD3 mRNA

NCBI chr20:13,129,555...13,145,100
Ensembl chr20:13,130,119...13,145,978

G

small nuclear ribonucleoprotein polypeptide E

decreases expression

tolcapone results in decreased expression of SNRPE mRNA

NCBI chr13:47,596,324...47,609,390
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310

G

small nuclear ribonucleoprotein polypeptide F

decreases expression

tolcapone results in decreased expression of SNRPF mRNA

NCBI chr 7:30,017,460...30,024,162
Ensembl chr 7:28,130,427...28,137,129

G

small nuclear ribonucleoprotein polypeptide G

decreases expression

tolcapone results in decreased expression of SNRPG mRNA

NCBI chr 4:120,369,676...120,377,263
Ensembl chr 4:118,812,252...118,819,826
Ensembl chr X:118,812,252...118,819,826

G

superoxide dismutase 1

decreases expression

tolcapone results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

tolcapone results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

signal recognition particle 14

decreases expression

tolcapone results in decreased expression of SRP14 mRNA

NCBI chr 3:125,896,128...125,899,819
Ensembl chr 3:105,442,198...105,445,859

G

SRP receptor subunit beta

affects binding

tolcapone binds to SRPRB protein

NCBI chr 8:112,647,577...112,661,524

G

SS18 like 2

decreases expression

tolcapone results in decreased expression of SS18L2 mRNA

NCBI chr 8:130,252,774...130,255,388
Ensembl chr 8:121,375,308...121,377,877

G

signal sequence receptor subunit 1

affects binding

tolcapone binds to SSR1 protein

NCBI chr17:27,039,203...27,067,352
Ensembl chr17:26,833,741...26,861,821

G

SH3 and cysteine rich domain 3

decreases expression

tolcapone results in decreased expression of STAC3 mRNA

NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:63,343,186...63,350,589

G

signal transducer and activator of transcription 3

increases expression

tolcapone results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

sulfotransferase family 2A member 1

affects binding

tolcapone binds to SULT2A1 protein

NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134

G

TATA-box binding protein associated factor 9

decreases expression

tolcapone results in decreased expression of TAF9 mRNA

NCBI chr 2:33,528,388...33,532,395
Ensembl chr 2:31,794,142...31,798,769

G

tubulin folding cofactor A

decreases expression

tolcapone results in decreased expression of TBCA mRNA

NCBI chr 2:27,745,985...27,800,624
Ensembl chr 2:26,011,795...26,065,907

G

transcription elongation factor A like 8

decreases expression

tolcapone results in decreased expression of TCEAL8 mRNA

NCBI chr X:103,962,930...103,965,000
Ensembl chr X:99,171,177...99,173,710

G

transferrin receptor 2

increases expression

tolcapone results in increased expression of TFR2 mRNA

NCBI chr12:24,744,450...24,761,413
Ensembl chr12:19,107,673...19,124,591

G

translocase of inner mitochondrial membrane 10

decreases expression

tolcapone results in decreased expression of TIMM10 mRNA

NCBI chr 3:90,315,048...90,318,613
Ensembl chr 3:69,908,456...69,911,940

G

translocase of inner mitochondrial membrane 44

affects binding

tolcapone binds to TIMM44 protein

NCBI chr12:7,410,424...7,428,179
Ensembl chr12:2,612,581...2,629,351

G

translocase of inner mitochondrial membrane 8 homolog B

decreases expression

tolcapone results in decreased expression of TIMM8B mRNA

NCBI chr 8:59,850,737...59,852,117
Ensembl chr 8:50,954,342...50,955,729

G

thymidine kinase 2

affects binding

tolcapone binds to TK2 protein

NCBI chr19:713,043...737,345
Ensembl chr19:708,891...730,924

G

TM2 domain containing 1

decreases expression

tolcapone results in decreased expression of TM2D1 mRNA

NCBI chr 5:118,136,299...118,177,639
Ensembl chr 5:113,020,760...113,050,933

G

transmembrane p24 trafficking protein 10

affects binding

tolcapone binds to TMED10 protein

NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:104,991,838...105,026,753

G

transmembrane p24 trafficking protein 4

affects binding

tolcapone binds to TMED4 protein

NCBI chr14:85,338,980...85,343,577
Ensembl chr14:81,125,053...81,129,631

G

transmembrane p24 trafficking protein 9

affects binding

tolcapone binds to TMED9 protein

NCBI chr17:9,034,797...9,039,311
Ensembl chr17:9,029,646...9,034,176

G

transmembrane protein 126A

decreases expression

tolcapone results in decreased expression of TMEM126A mRNA

NCBI chr 1:153,837,015...153,843,192
Ensembl chr 1:144,422,703...144,430,628

G

transmembrane protein 126B

decreases expression

tolcapone results in decreased expression of TMEM126B mRNA

NCBI chr 1:153,852,081...153,864,038
Ensembl chr 1:144,437,145...144,451,435

G

transmembrane protein 128

decreases expression

tolcapone results in decreased expression of TMEM128 mRNA

NCBI chr14:76,751,848...76,761,576
Ensembl chr14:72,539,532...72,548,550

G

transmembrane protein 203

decreases expression

tolcapone results in decreased expression of TMEM203 mRNA

NCBI chr 3:28,469,062...28,469,890
Ensembl chr 3:8,070,914...8,071,867

G

transmembrane protein 238

decreases expression

tolcapone results in decreased expression of TMEM238 mRNA

NCBI chr 1:78,085,880...78,091,272
Ensembl chr 1:69,056,805...69,076,133

G

transmembrane protein 256

decreases expression

tolcapone results in decreased expression of TMEM256 mRNA

NCBI chr10:55,056,959...55,058,869
Ensembl chr10:54,555,360...54,560,120

G

thymosin beta 4, X-linked

decreases expression

tolcapone results in decreased expression of TMSB4X mRNA

NCBI chr X:30,761,611...30,763,612
Ensembl chr X:27,128,610...27,146,667
Ensembl chr10:27,128,610...27,146,667

G

TNF alpha induced protein 8

affects binding

tolcapone binds to TNFAIP8 protein

NCBI chr18:45,370,334...45,486,036
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 1A

increases expression

tolcapone results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

translocase of outer mitochondrial membrane 20

affects binding

tolcapone binds to TOMM20 protein

NCBI chr19:71,822,429...71,832,420
Ensembl chr19:54,923,402...54,935,198

G

translocase of outer mitochondrial membrane 40

affects binding

tolcapone binds to TOMM40 protein

NCBI chr 1:88,486,745...88,498,833
Ensembl chr 1:79,358,786...79,370,915

G

translocase of outer mitochondrial membrane 7

affects binding

tolcapone binds to TOMM7 protein

NCBI chr 4:12,197,503...12,204,344
Ensembl chr 4:11,305,110...11,311,962

G

tumor protein p53 inducible protein 3

decreases expression

Tolcapone results in decreased expression of TP53I3 mRNA

NCBI chr 6:33,537,779...33,545,204

G

trafficking protein particle complex subunit 2L

decreases expression

tolcapone results in decreased expression of TRAPPC2L mRNA

NCBI chr19:67,570,954...67,574,722
Ensembl chr19:50,662,507...50,666,192

G

tetraspanin 6

decreases expression

tolcapone results in decreased expression of TSPAN6 mRNA

NCBI chr X:101,385,686...101,395,371
Ensembl chr X:97,092,388...97,099,309

G

tubulin, beta 6 class V

affects binding

tolcapone binds to TUBB6 protein

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:60,943,375...60,954,418

G

thioredoxin domain containing 17

decreases expression

tolcapone results in decreased expression of TXNDC17 mRNA

NCBI chr10:57,331,312...57,334,284

G

ubiquitin C-terminal hydrolase L3, pseudogene 1

decreases expression

tolcapone results in decreased expression of UCHL3-PS1 mRNA

NCBI chr 3:161,856,954...161,857,835

G

UDP glucuronosyltransferase family 1 member A9

decreases glucuronidation
increases glucuronidation

UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone
UGT1A9 protein results in increased glucuronidation of tolcapone

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

ubiquinol cytochrome c reductase core protein 2

affects binding

tolcapone binds to UQCRC2 protein

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

affects binding

tolcapone binds to UQCRFS1 protein

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:33,977,921...33,982,479

G

UV radiation resistance associated

increases expression

tolcapone results in increased expression of UVRAG mRNA

NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:153,185,395...153,442,136

G

voltage-dependent anion channel 2

affects binding

tolcapone binds to VDAC2 protein

NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,463,056...2,476,553

G

voltage-dependent anion channel 3

affects binding

tolcapone binds to VDAC3 protein

NCBI chr16:76,137,489...76,153,933
Ensembl chr16:69,435,005...69,451,471

G

visinin-like 1

affects binding

tolcapone binds to VSNL1 protein

NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:34,038,642...34,159,479

G

WASH complex subunit 3

decreases expression

tolcapone results in decreased expression of WASHC3 mRNA

NCBI chr 7:24,508,544...24,553,012
Ensembl chr 7:22,621,078...22,690,696

G

wolframin ER transmembrane glycoprotein

affects binding

tolcapone binds to WFS1 protein

NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602

G

tyrosyl-tRNA synthetase 1

increases expression

Tolcapone results in increased expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:141,535,759...141,563,833

G

YEATS domain containing 4

decreases expression

tolcapone results in decreased expression of YEATS4 mRNA

NCBI chr 7:54,744,220...54,751,361
Ensembl chr 7:52,858,305...52,865,635

G

zinc and ring finger 1

increases expression

tolcapone results in increased expression of ZNRF1 mRNA

NCBI chr19:56,403,816...56,490,901
Ensembl chr19:39,496,527...39,580,969

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19904
role	19875
biological role	19873
biochemical role	19583
enzyme inhibitor	18780
EC 2.* (transferase) inhibitor	14985
EC 2.1.* (C1-transferase) inhibitor	3779
EC 2.1.1.* (methyltransferases) inhibitor	691
EC 2.1.1.6 (catechol O-methyltransferase) inhibitor	353
entacapone +	26
tolcapone	346

paths to the root