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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-(3,4-dihydroxyphenyl)propanoic acid
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Accession:CHEBI:48400 term browser browse the term
Definition:A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. Also known as dihydrocaffeic acid, it is a metabolite of caffeic acid and exhibits antioxidant activity.
Synonyms:related_synonym: 3,4-dihydroxy-beta-phenylpropionic acid;   3,4-dihydroxybenzenepropanoic acid;   3,4-dihydroxybenzenepropionic acid;   3,4-dihydroxydihydrocinnamic acid;   3,4-dihydroxyhydrocinnamic acid;   3,4-dihydroxyphenylpropionic acid;   3-(3,4-dihydroxyphenyl)propionic acid;   Formula=C9H10O4;   InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13);   InChIKey=DZAUWHJDUNRCTF-UHFFFAOYSA-N;   SMILES=OC(=O)CCc1ccc(O)c(O)c1;   dihydrocaffeic acid;   hydrocaffeic acid
 alt_id: CHEBI:4556
 xref: CAS:1078-61-1;   Gmelin:482169;   HMDB:HMDB0000423;   KEGG:C10447;   KNApSAcK:C00002735
 xref_mesh: MESH:C000995
 xref: PMID:15607645;   PMID:22490054;   PMID:23904092;   Reaxys:2213449
 cyclic_relationship: is_conjugate_acid_of CHEBI:58744


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3-(3,4-dihydroxyphenyl)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO 3,4-dihydroxyphenylpropionic acid binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid
[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        antioxidant 16148
          3-(3,4-dihydroxyphenyl)propanoic acid 2
            N(1),N(8)-bis-(dihydrocaffeoyl)spermidine 0
            dihydrocaffeoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      monocarboxylic acid 18004
                                        fatty acid 16838
                                          saturated fatty acid 16560
                                            propionic acid 3874
                                              3-phenylpropionic acid 7
                                                3-(3,4-dihydroxyphenyl)propanoic acid 2
                                                  N(1),N(8)-bis-(dihydrocaffeoyl)spermidine 0
                                                  dihydrocaffeoyl-CoA 0
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