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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cinacalcet
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Accession:CHEBI:48390 term browser browse the term
Definition:A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.
Synonyms:exact_synonym: N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
 related_synonym: (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine;   CNC;   Formula=C22H22F3N;   InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1;   InChIKey=VDHAWDNDOKGFTD-MRXNPFEDSA-N;   Mimpara;   N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine;   SMILES=C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
 xref: CAS:226256-56-0;   DrugBank:DB01012;   Drug_Central:647;   KEGG:D03504;   LINCS:LSM-5815
 xref_mesh: MESH:D000069449
 xref: PMID:16680561;   PMID:17652181;   Patent:US2007060645;   Patent:US6011068;   Patent:US6211244;   Reaxys:10191346;   Wikipedia:Cinacalcet


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cinacalcet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Cinacalcet results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Klf2 KLF transcription factor 2 increases expression
decreases ubiquitination
multiple interactions		 ISO Cinacalcet results in increased expression of KLF2 protein
Cinacalcet results in decreased ubiquitination of KLF2 protein
[Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in decreased expression of KLF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein]		 CTD PMID:35635602 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Pth parathyroid hormone decreases expression
decreases secretion
multiple interactions		 ISO Cinacalcet results in decreased expression of PTH protein
Cinacalcet results in decreased secretion of PTH protein
[Cinacalcet co-treated with Vitamin D] results in decreased expression of PTH protein		 CTD PMID:17060004 PMID:18256372 PMID:21541686 PMID:22118402 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression		 ISO [Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein]
Cinacalcet results in decreased expression of TRAF2 mRNA; Cinacalcet results in decreased expression of TRAF2 protein		 CTD PMID:35635602 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        pharmaceutical 19550
          drug 19550
            calcimimetic 5
              cinacalcet 5
                cinacalcet carbamate 0
                cinacalcet hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            organic hydride 18704
                              organic fundamental parent 18704
                                hydrocarbon 18452
                                  halohydrocarbon 15873
                                    haloalkane 12913
                                      fluoroalkane 9231
                                        fluoromethanes 6775
                                          tetrafluoromethane 6775
                                            trifluoromethyl group 6775
                                              (trifluoromethyl)benzenes 6775
                                                cinacalcet 5
                                                  cinacalcet carbamate 0
                                                  cinacalcet hydrochloride 0
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